CN100352485C - Headache treating Chinese medicine and its prepn process - Google Patents
Headache treating Chinese medicine and its prepn process Download PDFInfo
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- CN100352485C CN100352485C CNB2005100400880A CN200510040088A CN100352485C CN 100352485 C CN100352485 C CN 100352485C CN B2005100400880 A CNB2005100400880 A CN B2005100400880A CN 200510040088 A CN200510040088 A CN 200510040088A CN 100352485 C CN100352485 C CN 100352485C
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Abstract
The present invention discloses a Chinese medicine for treating headaches and a preparation method thereof. In the preparation method, the Chinese medicines, such as yanhusuo, gastrodia elata, hemlock parsley, stiff silkorm, dahurian angelica, notopterygium incisium, kudzuvine root, parsnip, achyranthes root, viticis, platycodon root, etc., are used as raw materials; the gastrodia elata is pulverized into fine powder for later use; the yanhusuo, the hemlock parsley, the dahurian angelica, the notopterygium incisium and the parsnip are dipped and refluxed in etanol, and then is filtered, the etanol is recovered from filtered liquid, and then, the filtered liquid is concentrated for later use; the stiff silkworm, the kudzuvine root, the achyranthes root, the viticis and the platycodon root are dipped and decocted in water, and then are filtered, and the obtained filtered liquid is mixed with the concentrated filtered liquid; the mixed liquid is concentrated into thick paste, is placed at room temperature, is stirred by adding etanol, and is placed for one night; the etanol is recovered from alcohol liquid; then, alcohol extract is added, and then, the mixed liquid is concentrated into thick paste; the fine powder of the gastrodia elata is added; finally, the mixed liquid is manufactured into tablets, pills, medicinal powder, etc. by adding general excipients with a conventional preparation method. The Chinese medicine for treating headaches has the characteristics of good therapeutic effect and little side effect.
Description
Technical field
The invention belongs to drug world, especially relate to a kind of Chinese medicine for the treatment of headache.
Background technology
Headache is commonly encountered diseases, the frequently-occurring disease of harm health of people, and cause of disease complexity, clinical manifestation differ, changeful, always be considered as difficult and complicated illness by doctor family.Having a headache, especially migraine is obstinate difficult, and sharp ache causes spirit and sensual very big misery to the patient.According to China's 6 city migraine Epidemiological studys, prevalence is 6.3 ‰.Other has data to show, gender's prevalence respectively is 2.8 and 9.7 ‰, and the women is higher than 3.5 times of male.From sicken age, from the youngest beginning, prevalence increased with the age.Reach the peak in 20-30 year, descend then, old less.
The Chinese and western drugs of treatment headache at present is many, as the indometacin of prostaglandin inhibitor, the Ergotamine of vasoconstrictor, the propranolol of adrenergic receptor blocker, the flunarizine of calcium channel blocker, antiepileptic carbamazepine etc.; The ZHENNAONING of Chinese medicine, ZHENGTIAN WAN etc.The analgesic effect of these Chinese medicine and western medicine is sure, but certain side effect is arranged, and is not suitable for especially taking for a long time.For this reason, some good effects of introduction exploitation, side effect pure Chinese medicinal preparation little, taking convenience are that obvious social and economic benefit are arranged.
Summary of the invention
The preparation method of Chinese medicine that the purpose of this invention is to provide the little treatment headache of a kind of good effect, side effect.
Technical scheme of the present invention is such: a kind of preparation method of Chinese medicine for the treatment of headache, realized by the following step:
(1) Rhizoma Corydalis of preparation 80～150 weight portions, the Rhizoma Gastrodiae of 80～150 weight portions, the Rhizoma Chuanxiong of 80～150 weight portions, the Bombyx Batryticatus of 80～150 weight portions, the Radix Angelicae Dahuricae of 136～176 weight portions, the Rhizoma Et Radix Notopterygii of 136～176 weight portions, the Radix Saposhnikoviae of 80～150 weight portions, the Radix Puerariae of 80～150 weight portions, the Radix Achyranthis Bidentatae of 58～98 weight portions, the Radix Platycodonis of the Fructus Viticis of 19～59 weight portions and 58～98 weight portions, and be first group of medical material with the Rhizoma Gastrodiae of above-mentioned 80～150 weight portions, Rhizoma Corydalis with above-mentioned 80～150 weight portions, the Rhizoma Chuanxiong of 80～150 weight portions, the Radix Angelicae Dahuricae of 136～176 weight portions, the Radix Saposhnikoviae of the Rhizoma Et Radix Notopterygii of 136～176 weight portions and 80～150 weight portions is second group of medical material, with the Bombyx Batryticatus of above-mentioned 80～150 weight portions, the Radix Puerariae of 80～150 weight portions, the Radix Achyranthis Bidentatae of 58～98 weight portions, the Radix Platycodonis of the Fructus Viticis of 19～59 weight portions and 58～98 weight portions is the 3rd group of medical material;
(2) above-mentioned first group of medical material is broken into fine powder;
(3) get above-mentioned second group of medical material with 5～10 times of amount soak with ethanol of 50%～95% 10～60 minutes, through refluxing, filter, filtrate recycling ethanol, being concentrated into relative density is 1.01～1.25;
(4) filterable medicinal residues in the step 3 are added above-mentioned the 3rd group of medical material, decoct with water, filter, filtrate is concentrated into thick paste, cooling, add 1～3 times of amount 50%～95% ethanol and mix thoroughly, placed 8～12 hours, filter, filtrate recycling ethanol, add the filtrate after the concentrating of step 3 gained again, be concentrated into the thick paste shape, the Rhizoma Gastrodiae fine powder mixing that adds in the step (2) gets final product.
The thick paste adding usual excipients that is mixed with Rhizoma Gastrodiae fine powder of above-mentioned steps (4) gained is made tablet or pill or powder by conventional method.
Migraine belongs to the traditional Chinese medical science " migraine " category, and is left or right with outbreak repeatedly, and the unexpected severe headache of making a return journey is the headache illness of main performance.Its pathogenesis is a qi and blood stagnation brain network, pathogen upward attacking orifices in head, and cause headache.Control suitable blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, expel wind to dredge collateral.In conjunction with practical experience, select Rhizoma Chuanxiong for use is monarch drug to the inventive method according to above-mentioned theory of Chinese medical science, gets its warm promoting blood circulation, dredges to reach QI and blood, and the up head can blood circulation promoting and blood stasis dispelling, and the merit of activating QI to alleviate the depression is arranged again.Get the Rhizoma Gastrodiae suppressing the hyperactive liver to relieve the wind syndrome, logical blood circulation regulating; The Rhizoma Corydalis wind pain relieving of loosing; Bombyx Batryticatus is expellingged wind and relieving convulsion, and active stimulating the menstrual flow is ministerial drug altogether.Get the pain relieving of fang-feng powder wind; Radix Puerariae, Fructus Viticis yang invigorating, dispelling wind, pain relieving; Radix Achyranthis Bidentatae stimulates the menstrual flow, invigorates blood circulation, pain relieving; Radix Platycodonis eliminates the phlegm, and up being total to helping of year all medicines makes.Above-mentioned all medicines share, and play the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, expel wind to dredge collateral altogether, and migraine has significant curative effect to having a headache especially.
Pharmacodynamics test shows, the Chinese medicine of treatment headache prepared according to the methods of the invention to the hemorheological property due to the rat stasis syndrome type " glue ", " dense ", " coagulating " state have obviously and alleviate, and obvious inhibition rabbit thoracic aortic ring contraction is arranged; Pain reaction to white mice acetic acid twisting method, afterbody electrostimulation and hot plate method cause has the analgesic activity that improves pain threshold; The white mice auricle inflammation swelling that xylol causes, the rat ankle arthroncus that carrageenin causes and rat filter paper bury the chronic granuloma that causes all inhibitory action, simultaneously, certain sedative-hypnotic effect is arranged.These results provide experimental basis for the present invention treats migraine.
Acute and chronic toxicity test shows, the Chinese medicine acute toxicity test of treatment headache prepared according to the methods of the invention, and Bliss method statistic law is calculated LD
50And L
95Result: LD
50=23.0459gkg
-1(contain crude drug amount 8 0.661gkg
-1); L
95=20.762gkg
-1(contain crude drug amount 72.667gkg
-1～89.533gkg
-1), illustrate that a kind of Chinese medicine for the treatment of headache of the present invention belongs to nontoxic.Chronic toxicity test is irritated stomach with the Chinese medicine of treatment headache prepared according to the methods of the invention to rat: 4g, 2g and 1gkg
-1D
-1(contain crude drug 14g, 7g and 3.5gkg
-1D
-1) and normal (ordinary water) matched group.Every day 1 time, continuous 45 days.The result is tried Mus and is not seen toxic reaction, hematological indices, blood parameters, system become celestial and histopathologic examination all no abnormal, the conversion of its high dose is equivalent to 166.7 times of clinical application amount.Therefore, can think that the Chinese medicine of treatment prepared according to the methods of the invention headache is without any side effects to human body.
The specific embodiment
A kind of preparation method of Chinese medicine for the treatment of headache of the present invention, realized by following steps:
1, gets Rhizoma Corydalis 117 grams, Rhizoma Gastrodiae 130 grams, Rhizoma Chuanxiong 130 grams, Bombyx Batryticatus 130 grams, the Radix Angelicae Dahuricae 156 grams, Rhizoma Et Radix Notopterygii 156 grams, Radix Puerariae 130 grams, Radix Saposhnikoviae 130 grams, Radix Achyranthis Bidentatae 78 grams, Fructus Viticis 39 grams, Radix Platycodonis 78 grams; And with above-mentioned 130 the gram Rhizoma Gastrodiaes be first group of medical material, with above-mentioned 117 gram Rhizoma Corydalis, 130 gram Rhizoma Chuanxiongs, the 156 gram Radixs Angelicae Dahuricae, 156 gram Rhizoma Et Radix Notopterygiis and 130 gram Radix Saposhnikoviaes is second group of medical material, is the 3rd group of medical material with above-mentioned 130 gram Bombyx Batryticatus, 130 gram Radix Puerariaes, 78 gram Radix Achyranthis Bidentataes, 39 gram Fructus Viticises and 78 gram Radix Platycodoniss.
2, above-mentioned first group of medical material is broken into fine powder, crosses the 100# sieve, standby.
3, get above-mentioned second group of medical material with 8 times of amount soak with ethanol of 95% 30 minutes, refluxed 2 hours, filtration, filtrate recycling ethanol is concentrated into relative density and is 1.04～1.06, and is standby.
4, filterable medicinal residues in the step 3 are added above-mentioned the 3rd group of medical material, soak half an hour, decoct secondary, add 10 times of water gagings for the first time, decocted 2 hours, add for the second time 8 times of water gagings, decocted 1 hour, and filtered respectively, the filtrate that secondary is decocted gained is mixed, be concentrated into thick paste (relative density is greater than 1.20), put to room temperature, add 2 times of amount 95% ethanol and mix thoroughly, placed 12 hours, filter, filtrate recycling ethanol, the relative density that adds step 3 gained again is 1.04～1.06 concentrated filtrate, mix homogeneously, be concentrated into the thick paste shape, add the Rhizoma Gastrodiae fine powder mixing in the step 2.
5, the thick paste adding that is mixed with Rhizoma Gastrodiae fine powder with step 4 gained restrains dextrin as 11 of dry adhesive, mixing, granulate by conventional method, under 60～65 ℃ temperature, dry, the weight that adds as lubricant in every is that granule weighs 0.5% magnesium stearate, mixing, tabletting, the headache tablets that gets product, every heavily about 0.3 gram.
Usage and consumption: each 2, every day 2 times, one after each meal, oral.
The Chinese medicine of treatment headache prepared according to the methods of the invention after finishing pharmacy, main pharmacodynamics, toxicologic study work, entrusts Ministry of Public Health Fujian Institute of Traditional Chinese Medicine clinical pharmacology base to carry out clinical preliminary test.Migraineur's 88 examples (test group 55 examples, matched group 33 examples) are made a definite diagnosis in selection, and 15 days courses of treatment, the result shows, the Chinese medicine of treatment headache prepared according to the methods of the invention, cure rate 42%, obvious effective rate 24%, effective percentage 27%, inefficiency 7%, total effective rate 93%.
Model case: Zheng * *, the women, 35 years old, left side headache 6 years was seen and was increased the weight of in nearly one month, outbreak in every 3-5 days once, pain as being stabbed, with dizziness, pale complexion, cold sweat, vomiting, weak, dormancy is poor.Take the Chinese medicine of treatment headache prepared according to the methods of the invention, every day 2 times, each 2 (every heavily about 0.28 gram), and oral, promptly had a headache the same day of taking medicine and obviously alleviated, symptom all disappeared in 5 days, observed again and did not see outbreak in 8 months.
Claims (2)
1, a kind of preparation method of Chinese medicine for the treatment of headache is characterized in that: realized by the following step:
(1) Rhizoma Corydalis of preparation 80～150 weight portions, the Rhizoma Gastrodiae of 80～150 weight portions, the Rhizoma Chuanxiong of 80～150 weight portions, the Bombyx Batryticatus of 80～150 weight portions, the Radix Angelicae Dahuricae of 136～176 weight portions, the Rhizoma Et Radix Notopterygii of 136～176 weight portions, the Radix Saposhnikoviae of 80～150 weight portions, the Radix Puerariae of 80～150 weight portions, the Radix Achyranthis Bidentatae of 58～98 weight portions, the Radix Platycodonis of the Fructus Viticis of 19～59 weight portions and 58～98 weight portions, and be first group of medical material with the Rhizoma Gastrodiae of above-mentioned 80～150 weight portions, Rhizoma Corydalis with above-mentioned 80～150 weight portions, the Rhizoma Chuanxiong of 80～150 weight portions, the Radix Angelicae Dahuricae of 136～176 weight portions, the Radix Saposhnikoviae of the Rhizoma Et Radix Notopterygii of 136～176 weight portions and 80～150 weight portions is second group of medical material, with the Bombyx Batryticatus of above-mentioned 80～150 weight portions, the Radix Puerariae of 80～150 weight portions, the Radix Achyranthis Bidentatae of 58～98 weight portions, the Radix Platycodonis of the Fructus Viticis of 19～59 weight portions and 58～98 weight portions is the 3rd group of medical material;
(2) above-mentioned first group of medical material is broken into fine powder;
(3) get above-mentioned second group of medical material with 5～10 times of amount soak with ethanol of 50%～95% 10～60 minutes, through refluxing, filter, filtrate recycling ethanol, being concentrated into relative density is 1.01～1.25;
(4) filterable medicinal residues in the step 3 are added above-mentioned the 3rd group of medical material, decoct with water, filter, filtrate is concentrated into thick paste, cooling, add 1～3 times of amount 50%～95% ethanol and mix thoroughly, placed 8～12 hours, filter, filtrate recycling ethanol, add the filtrate after the concentrating of step 3 gained again, be concentrated into the thick paste shape, the Rhizoma Gastrodiae fine powder mixing that adds in the step (2) gets final product.
2, a kind of preparation method of Chinese medicine for the treatment of headache according to claim 1 is characterized in that: the thick paste adding usual excipients that is mixed with Rhizoma Gastrodiae fine powder of above-mentioned steps (4) gained is made tablet or pill or powder by conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100400880A CN100352485C (en) | 2005-05-14 | 2005-05-14 | Headache treating Chinese medicine and its prepn process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100400880A CN100352485C (en) | 2005-05-14 | 2005-05-14 | Headache treating Chinese medicine and its prepn process |
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| Publication Number | Publication Date |
|---|---|
| CN1706460A CN1706460A (en) | 2005-12-14 |
| CN100352485C true CN100352485C (en) | 2007-12-05 |
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|---|---|---|---|
| CNB2005100400880A Expired - Fee Related CN100352485C (en) | 2005-05-14 | 2005-05-14 | Headache treating Chinese medicine and its prepn process |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670732B (en) * | 2012-05-29 | 2014-12-03 | 陕西新药技术开发中心 | Medicament for treating headache |
| CN103006910B (en) * | 2012-12-17 | 2014-12-10 | 杜言辉 | Externally-used traditional Chinese medicine composition for treating migraine |
| CN103948699B (en) * | 2014-04-21 | 2016-02-10 | 孙喜稳 | One treats migrainous Chinese medicine composition |
| CN104116932A (en) * | 2014-06-26 | 2014-10-29 | 凤台县中医院 | Traditional Chinese medicine composition for treating intractable headache |
| CN105233167A (en) * | 2015-11-06 | 2016-01-13 | 青岛麦瑞特医药技术有限公司 | Medicine composition for treating vascular neuralgia headache |
| CN110613799A (en) * | 2019-09-05 | 2019-12-27 | 许哲辉 | Preparation method of traditional Chinese medicine for treating headache |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226045A (en) * | 1998-02-06 | 1999-08-18 | 曼那斯曼Vdo公司 | Running recorder with longitudinal casing |
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2005
- 2005-05-14 CN CNB2005100400880A patent/CN100352485C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226045A (en) * | 1998-02-06 | 1999-08-18 | 曼那斯曼Vdo公司 | Running recorder with longitudinal casing |
Non-Patent Citations (1)
| Title |
|---|
| 失眠临床辨证论治探讨 施明，徐建，许红，王翘楚.上海中医药杂志，第37卷第3期 2003 * |
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