CN1239193C - Chinese medicine for treating trigeminal neuralgia and its preparation method - Google Patents
Chinese medicine for treating trigeminal neuralgia and its preparation method Download PDFInfo
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Abstract
The present invention relates to traditional Chinese medicine for treating trigeminal neuralgia and a preparation method thereof. The traditional Chinese medicine is prepared by using hemlock parsley, tall gastrodia tubers, schizonepeta spike, shrub chastetree fruit, asarum herbs, white mustard seeds, etc. as raw materials which are respectively processed in different groups according to the characteristics of different medicinal materials through a specified technology. The raw materials can be prepared into the preparation forms of medicinal powder, capsules, watered pills, honeyed pills, medicinal granules, etc. The present invention has the characteristics of high analgesia index, high analgesia time value, long medicine effect, little side effect, etc., and also has the functions of changing the internal pathological process of a nervous system at the same time of analgesia and recovering the normal physiological function of pathological nerves. The traditional Chinese medicine can be used singly and can also be used by matching with the western medicine of carbamazepine for playing a synergistic effect, and moreover, the traditional Chinese medicine can reduce the side effect of the carbamazepine and decrease adverse reactions. When the present invention is used for treating primary trigeminal neuralgia in clinical application, the effective rate of the present invention reaches 97.4%, and the recovery rate and the effectual rate of the present invention reach 88.4%. In addition, the traditional Chinese medicine can also be used for treating angioneurotic headaches, migraine, tension headaches, etc.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to prosopalgic Chinese medicine of a kind of treatment and preparation method thereof.
Background technology
Trigeminal neuralgia be a kind of be the disease of cardinal symptom with the spontaneous paroxysmal pain of women's head-ornaments portion.Aching as needle stabbing during outbreak, lancinate, lightning, very violent.Factors such as Chang Yin washes one's face, takes food, illustrates even mild wind blows on one's face and cause outbreak.
Prosopalgic etiology and pathology is very complicated, and is not clear fully as yet so far.But there is clinical data to show, the existence of perstriction Roots of trigeminal nerve and nervi trigeminus harden plaque, and the myelin hypertrophy that takes place gradually therefrom, take off mistake, the axon short circuit is its main cause of disease and pathology, and this demyelination pathological changes is often relevant with the imbalance of immunologic function.Often by means of some meson between neuroglia and synapse cell, afferent neuron constantly causes the opening of pain sensation gate and causes pain as for the generation of pain.In a word, the prosopalgic cause of disease is in periphery, pathological process shows maincenter, can make the enhanced disease of nervi trigeminus activeness, damaged simultaneously and normally imported active inhibition mechanism in the nucleus of spinal tract into, caused the interior neuron impulsion of spinal nucleus of trigeminal nerve to break out, activated the thalamic pain neuron through lemniscus trigeminalis, be projected to the cortex sensory centre, this moment, the patient just showed fulminating trigeminal neuralgia.
In theory, treat prosopalgic ideal scheme and have 1) alleviate or change the pathological changes of perstriction nerve root; 2) improvement or reparation nervi trigeminus plaque, and the myelin hypertrophy that produces therefrom take off diseases such as mistake; 3) the interior environment of improvement or adjustment nervi trigeminus system comprises the ICC composition, causes pain meson and the cell-membrane receptor resistance capabilities to the painful meson; 4) in time suppress or prevent breaking out of unusual pain sensation current potential ahead of time, promptly control pain sensation gate and neural short circuit; 5) suppress cerebral cortex pain sensation maincenter in case of necessity, also can be as interim plan.
The prosopalgic method of treatment is a lot of at present, roughly comprises surgical treatment, Western medicine therapy, herbal treatment, acupuncture and moxibustion treatment, various sealing, laser and gamma knife etc.
Surgical method: roughly can divide peripheral ramifications excision and extract out and remove art, Roots of trigeminal nerve partly excision and spinal tract of trigeminal nerve amputation etc., with the conduction of the blocking-up pain sensation to reach the pain relieving purpose.Discover that 92.5% trigeminal neuralgia patient exists the phenomenon of perstriction nerve root, adopted MVD to treat in view of the above, but still have mortality rate about 1% and the relapse rate of 22-26%.
Trifacial gamma knife treatment method: from Raneld in 1997 etc. radix sensoria nervi trigemini is implanted the pon place and carry out the gamma ray irradiation as target spot, all effective to the trigeminal neuralgia due to constitutional and the tumor of base of skull.Key is accurate positioning, the dosage abundance.Advantage is no wound, few untoward reaction, few complication; But its location and irradiation dose be difficult for to be grasped, and inaccurately cause the treatment failure in case calculate, and the treatment back fully the analgesic time needed 2-3 month, make general income person be difficult to accept.
Percutaneous puncture semilunar ganglion radio frequency heat is coagulated art: proved by experiment from Smeet that the fine fibre of the nonmedullated nerve conduction pain sensation is used at the 70-75% heat albuminous degeneration can take place, and lost the conduction function of the pain sensation; And medullated crude fibre can tolerate higher temperature and do not lose sense of touch and this principle of movement sensation function, and using temperature control heat, to coagulate therapy be that a kind of new effective therapy has been opened up in prosopalgic treatment.Its advantage is that pain relieving is rapid, and is easy to operate and safe, can keep facial sense of touch, than other surgical treatment certain advance arranged.But it is a kind of damage Therapeutic Method, and is relatively more painful during puncture, the relapse rate height.
Treatment with western: after synthesizing carbamazepine by Switzerland Sehnieler in 1961, carbamazepine just becomes trigeminal neuralgia patient's first-selected medicine.Its mechanism of action may be to suppress the transmission between brain stem spinal nucleus of trigeminal nerve synapse cell and play analgesic effect.Use that analgesic effect is good the initial stage, curative effect reaches 70-80%, yet along with the increasing of clinical practice, its toxic and side effects also more and more exposes, and that main adverse reaction has is dizzy, nausea and vomiting, arrhythmia etc. do not descend the 30-40 kind.According to external Cullen, have 44% untoward reaction to occur in the carbamazepine treatment again.Therefore the treatment trigeminal neuralgia is produced in the Karma west, though analgesic effect is good, is forced to stop treatment because of its serious toxic and side effects usually makes the patient, so its actual healing is very low.
The traditional Chinese medical herbal treatment trigeminal neuralgia: the Chinese medicine trigeminal neuralgia is with a long history, and traditional traditional Chinese medical science is usually according to reason side's medicine principle of the traditional Chinese medical science, diagnosis and treatment based on an overall analysis of the illness and the patient's condition.As Wang Shi primary disease is divided on syndrome of liver-stomach heat transformation of fire and occurrence of wind syndrome type, the positive bright excess-heat and disturbs four types such as people's key type, type of deficiency of YIN leading to hyper activity of YANG and affection by exopathogenic cold-wind type.Use treatments such as SANHUANG XIEXIN TANG, rhizome of chuanxiong chrysanthemum soup, letter Ju Dihuang ball, Herba Asari Shigao Tang respectively, obtain gratifying curative effect.And Fang Shi is divided into wind heat, wind and cold, deficiency of YIN heat in blood three types with trigeminal neuralgia.Kind surplus used prescription reaches 10.Other each tame institute opinion respectively has experience, is not quite similar.Yet the method for determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs be actually a disease in many ways, face disease and must add and subtract, each prescription only can be applicable to a patient, is applicable to certain colony in a certain class syndrome at most, lacks universality, and is difficult for forming production scale.
Treat problem and the difficult point following points thereof that trigeminal neuralgia exists at present:
1) subject range of surgical method is limited.In surgical method, the method of various art formulas, though make prosopalgic treatment work obtain bigger progress, yet because of the difficulty of its operation bigger, medical condition is had relatively high expectations, and the complication of postoperative is difficult to avoid fully in the art, and risk is bigger, especially the crowd of incompatibility advanced age, weak, many diseases, subject range is little.
2) serious adverse reaction in the Drug therapy.The prosopalgic main medicine of western medicine still is a carbamazepine at present, because it can suppress the breaking out of insane pain sample pain sensation current potential of nervi trigeminus central position, and rapid and powerful analgesic activity is arranged, be that any other class medicine is irreplaceable, yet the toxic and side effects that it is serious is more and more paid close attention to by most of patients.It is reported that the untoward reaction of carbamazepine has (1) neural dizziness, weak, fidgety, drowsiness, diplopia, trembles, involuntary movement, ataxia, language are ambiguous, mental disorder etc.; (2) cardiovascular system can cause arrhythmia, hypotension, sinus tachycardia, atrioventricular block, heart failure and A Si syndrome; (3) blood system can cause thrombocytopenia, leukopenia, aplastic anemia; (4) digestive system can cause nausea, vomiting, anorexia, hematemesis, abnormal liver function; (5) the skin aspect can cause anaphylactoid purpura, dermatomyositis, exfoliative dermatitis, erythema generation lupus; (6) genitourinary system can cause albuminuria, urine retention, renal failure; (7) anemia of pregnant woman can cause monster, all this or the like do not descend more than the 30-40 kind, and its incidence rate is up to 44%, makes the patient have no alternative but the Halfway Stopping treatment.
The prosopalgic toxic and side effects of treatment by Chinese herbs is not allowed not look yet.As everyone knows, the analgesic of Herba Asari for using always closely has report to have the clothes Herba Asari lip to occur after 1-2 hour and brothers are numb, heart rate increases, and reaches the peak in 2-3 hour, and changes into nodal rhythm by sinus rhythm.There are some researches prove that also the MLD of Herba Asari volatile oil mouse peritoneal injection is 200mg/kg, LD50 is 247mg/kg, in addition, and as Scorpio, Scolopendra, Rhizoma Typhonii etc. the also report of most toxic side effect.
As the saying goes: disease is not controlled the people, and the bad doctor kills a person.Wherein promptly comprise Drug abuse, do not note the toxic and side effects of medicine, the meaning of mistake people life.Thereby how correctly to use medicine, and the adjustment how process is filled a prescription makes it to bring into play maximum analgesic effect, reduces untoward reaction again as much as possible, and especially resembling the so disease of enough courses of treatment that needs of trigeminal neuralgia more must be like this, with the assurance patient safety.
3) Chinese herbal treatment trigeminal neuropathy analgesic effect is slow relatively; The aid is too slow to be helpful.The Chinese herbal and crude drugs preparations of manufacturing with traditional method, its analgesia index not only has big gap than chemical drugs, and its drug effect peak value also than chemical drugs come slowly, this point is nothing serious concerning chronic disease, and concerning the trigeminal neuralgia that pain usually breaks out, does not often reach the rapid analgesic requirement of patient, even Chinese medicine injection was arranged modern age, and the extraction of volatile oil, that also only is single medicinal material, is not a complete prescription.
4) unavoidable high relapse rate.Acupuncture and block therapy, or desirable the effect in for the moment, however effect is difficult to consolidate.Carbamazepine treatment trigeminal neuralgia, its relapse rate reaches more than 50%.The prosopalgic prescription method of Chinese medicine is a lot of, and the right cure rate of report mostly is some, year recurrence half a year to one at most, seldom report 3 years, 5 years after what state.Recidivist behind the gamma knife treatment, recidivist after the operation of opening cranium, radio frequency heat is coagulated the postoperative recurrence person ... there is higher recurrent rate really in all polytherapies.Trace it to its cause, nothing more than: in the relation of topical therapeutic and wholistic therapy, notice that local person is many, and whole person is few; In the relation of taking stopgap measures and effecting a permanent cure, the analgesia person of taking stopgap measures is many, and the person of effecting a permanent cure is few; Even comprise that the understanding degree of depth to this disease essence of trigeminal neuralgia does not reach very clear and definite degree yet.
Though the treatment trigeminal neuralgia also exists problems and difficult point at present, according to its pathology, the application Chinese medicine is treated and is reached ideal effect and still have feasibility." interior warp " has cloud: " head is the mansion of clear sun, the confluence of all yang-channels, 365 networks belong on all ".Therefore no matter the diseases caused by exogenous pathogenic factor internal injury all can directly or indirectly cause the closing of sky key, and clear sun is not transported, and sends out the disease of headache prosopodynia.Yet " on the high mountain peak, only wind can reach, and ailment said due to cold or exposure rise to be sent out, and easily violates women's head-ornaments, ailment said due to cold or exposure every with cold, the fire-phlegm clamping heresy of holding concurrently so that wind and cold stagnates, or wind-fire disease such as burn.Pain is gone into network for a long time, or the stagnation of QI and can not promoting the circulation of blood, or the deficiency of vital energy can not handsome blood, puckery to the blood walking retardation in children eventually, blood stasis network numbness forms Persistent Pain, just as " case of clinical finger face " cloud: " just be depressed; then blood is hindered into network for a long time; " at warp " internal medicine is faced the card record " be cloud also: " the nutrient blood stasis of blood hinders, and clearing heat in QI system can not be gone up the Rong Zi brain and cause headache person ... " all emphasized the importance of this pathology of blood stasis, and Zhang Shi proposes simultaneously: " ... pain of a specified duration is many based on internal injury; visceral dysfunction ... or deficiency of YIN anemia; venation is lost foster and is given birth to bitterly ... " meet " all pains source is waited the opinion headache and waited " institute's cloud basically: " women's head-ornaments wind person is a body void, and all yang channel arteries and veins are by being taken advantage of also ... " argument.Therefore think that the prosopalgic basic cause of disease is void, is wind.Its basic pathology is that the stasis of blood can be held concurrently, the stagnation of QI, phlegm-damp or fire, the also visceral dysfunction of can holding concurrently.So must be eliminating evil with dispelling wind, disperse blood stasis and dredge collateral, method is taken in the easing the affected liver analgesia as the leading factor.
In view of this, the perstriction Roots of trigeminal nerve have intrinsic the contact with the blood stasis traditional Chinese medical science, can use Chinese medicine " blood circulation promoting and blood stasis dispelling " method and solve.The Therapeutic Method of " blood circulation promoting and blood stasis dispelling " is the invaluable experience of Chinese medicine, and the doctor family of Gu is early on the books, says as " element asks YIN YANG classification of natural phenomena big opinion ": " dredge its QI and blood, make its accent reach and make peace flat ".Clear Wang Qingren was once founded " decoction for removing blood stasis " and said: looking into the person of suffering from headaches does not have table disease, does not have the disease of showing, the no deficiency of vital energy, and phlegm retention etc., the criminal of neglecting neglects, hundred side nonresponders.Therefore potion can be healed " figuratively speaking understand the prosopalgic experience of activating blood and resolving stasis and treating, back physicians from a family for generations family carries forward the cause of the older generation and break new ground, and has accumulated a lot of experiences, and " invigorate blood circulation and search wind " soup, treatment trigeminal neuralgia are intended in propositions such as noble society " blood resistance channels stagnation of QI and blood may bring about pain " certainly.This shows that the method for Chinese medicine " blood circulation promoting and blood stasis dispelling " can treated trigeminal neuralgia to trifacial compressing phenomenon than large program change blood vessel.
In addition, how to improve the existence and the myelin hypertrophy thereof of nervi trigeminus harden plaque and take off pathological phenomenons such as mistake, Chinese medicine has its unique advantages.The formation of neurosclerosis speckle according to the study, except that the reason of restricting and suppressing by means of administrative decrees, etc. with blood, still closely related with the Nutrition and Metabolism disorder of myelin, and support trifacial sclerosis of blood vessels, blood supply insufficiency and essential amino acid, vitamin, the shortage of enzyme, all can become important step, though above pathological changes can be utilized the Western medicine vitamin B complex, P family, protein etc. are replenished, all not as " setting upright " method of the traditional Chinese medical science, remove to improve the absorption transformation function of body, the meaning of so-called " ineffectual remedy " not as removing burning wood away under the boiler.And the traditional Chinese medical science " blood circulation promoting and blood stasis dispelling " method is own, not only can remove card and press phenomenon, can improve nervi trigeminus again and support the blood flow state of blood vessel, strengthen metabolic processes, the pathological changes of myelin is corrected, and Chinese crude drug itself promptly contains the necessary material of nerve growths such as a large amount of vitamin aminoacid, we can say that correcting this type of pathological changes with Chinese medicine has the superiority of achieving many things at one stroke.
Summary of the invention
In order to overcome the existing the problems referred to above of present treatment trigeminal neuralgia, the present invention is from trigeminal neuralgia characteristics and pathology, take into full account mark and this and whole and partial Dialectic Relationship, develop a kind of Chinese medicine preparation to reach following purpose: 1) make it to remove the nervi trigeminus cause of disease, can change its pathological process again, recover trifacial normal function; 2) improve curative effect, reduce relapse rate, quickly easing pain combines with long-acting analgesic; 3) Maximum Safety reduces and alleviates untoward reaction; 4) adapt to most of trigeminal neuralgia patient.Main points of the present invention are as follows:
At first, trigeminal neuralgia is a kind of idiopathic paroxysmal pain, usually breaks out.Therefore preventing in advance or quickly alleviating pain, is one of measures necessary.Chinese medicine analgesic advantage is clear and definite, but the time-consuming ball powder of traditional Chinese herbs decoction absorbs slowly the requirement that does not obviously reach quickly alleviating pain.Make it to strengthen infiltration rate by changing dosage form and using advanced more processing technique, also can use with obvious quick-acting classes analgesic Western medicine compatibility is arranged.
Next is the relapse rate problem, is exactly that pathological change fails to correct fully in fact, and the cause of disease does not eliminate, or in the relation of taking stopgap measures and effecting a permanent cure, in part and the whole relation, the latter's treatment is insufficient or imprecise.Therefore in prosopalgic treatment, strengthen etiological treatment, the pathogenesis that comprehensively hits is used neurohistology principle and cellular elements theory and is furtherd investigate, and with the neural normal function of thorough recovery, avoids recurrence.
Secondly be the toxic and side effects problem again, this is the common problems of paying close attention to of all personages of the world of medicine, and China's Chinese materia medica has one's own knack to this.The combination principle of so-called monarch, it crosses the toxicity that bias caused of victory to have comprised the assistant system in fact.It is detoxification that method roughly has two: one, fries in shallow oil for a long time as being decocted first of Radix Aconiti Lateralis Preparata; The vinegar of Semen Strychni soaks, fried, and unhairing etc. all be; Two is antitoxin, such as: must use Gypsum Fibrosum with Herba Asari; Must add the Radix Rehmanniae, Radix Scutellariae, resist its scorching property with Radix Aconiti Lateralis Preparata, Radix Aconiti to tie.All this or the like be the method that reduces toxic and side effects.In the prosopalgic prescription of many treatments, contain scorching poisonous product such as Radix Aconiti Lateralis Preparata, Herba Asari, Scorpio, Scolopendra mostly.If assistant system not, its scorching bias of crossing victorys is the source of toxic and side effects untoward reaction, and especially to this obstinate disease of trigeminal neuralgia, treatment cycle is longer, as if the system of being helped not, causes drug withdrawal midway easily, can not adhere to treating, down to defeat result.
Technical scheme of the present invention is as follows:
The prosopalgic Chinese medicine of a kind of treatment, it is by making by following materials of weight proportions:
Part 1:
Rhizoma Chuanxiong 6-18 part Radix Angelicae Sinensis 2-6 part Radix Paeoniae Alba 4-12 part Rhizoma Typhonii 1-3 part
Semen Sinapis Albae 1.5-4.5 part Radix Stephaniae Tetrandrae 1-3 part Rhizoma Cyperi 1.5-4.5 part Radix Bupleuri 1.5-4.5 part
Mustard fringe 1-3 part Fructus Viticis 1-3 part Radix Puerariae 1-3 part
Part 2:
Radix Scutellariae 1-3 part Herba Artemisiae Scopariae 1-3 part Semen phaseoli radiati 1-3 part Radix Glycyrrhizae 1-3 part
Folium Ilicis 0.5-1.5 part
The 3rd part:
Rhizoma Gastrodiae 2-6 part Herba Asari 2-6 part Rhizoma Corydalis 1.5-4.5 part Radix Angelicae Dahuricae 1-3 part Scorpio 1-3 part
Scolopendra 0.5-1.5 part Bombyx Batryticatus 1.5-4.5 part Cornu Cervi 0.5-1.5 part Margarita 0.5-1.5 part
Preferred technique scheme of the present invention, the prosopalgic Chinese medicine of a kind of treatment, it is by making by following materials of weight proportions:
Part 1:
1 portion of Caulis et Folium Sinapis albee of 4 parts of Rhizoma Typhoniis of 2 portions of Radix Paeoniae Albas of 6 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong is in 1.5 parts
1 part of 1 part of Fructus Viticis of 1.5 parts of Herba Schizonepetaes of 1.5 parts of Radix Bupleuri of 1 part of Rhizoma Cyperi of Radix Stephaniae Tetrandrae
1 part of Radix Puerariae;
Part 2:
1 part of 1 part of Folium Ilicis of 1.5 portions of Radix Glycyrrhizaes of 1.5 portions of Semen phaseoli radiatis of 1.5 portions of Herba Artemisiae Scopariaes of Radix Scutellariae
The 3rd part:
1 part of 1 portion of Scorpio of 1.5 parts of Radixs Angelicae Dahuricae of 2 parts of Rhizoma Corydalis of 2 parts of Herba Asaris of Rhizoma Gastrodiae
0.5 part of 0.5 part of Margarita of 1.5 parts of Cornu Cervis of 0.5 portion of Bombyx Batryticatus of Scolopendra.
Another technical scheme of the present invention, the prosopalgic Chinese medicine of a kind of treatment, it is by making by following materials of weight proportions:
Part 1:
Rhizoma Chuanxiong 6-18 part Radix Angelicae Sinensis 2-6 part Radix Paeoniae Alba 4-12 part Rhizoma Typhonii 1-3 part
Semen Sinapis Albae 1.5-4.5 part Radix Stephaniae Tetrandrae 1-3 part Rhizoma Cyperi 1.5-4.5 part Radix Bupleuri 1.5-4.5 part
Mustard fringe 1-3 part Fructus Viticis 1-3 part Radix Puerariae 1-3 part
Part 2:
Radix Scutellariae 6-12 part Herba Artemisiae Scopariae 6-12 part Semen phaseoli radiati 6-12 part Radix Glycyrrhizae 5-10 part Folium Ilicis 6-12 part
The 3rd part:
Rhizoma Gastrodiae 2-6 part Herba Asari 2-6 part Rhizoma Corydalis 1.5-4.5 part Radix Angelicae Dahuricae 1-3 part Scorpio 1-3 part
Scolopendra 0.5-1.5 part Bombyx Batryticatus 1.5-4.5 part Cornu Cervi 0.5-1.5 part Margarita 0.5-1.5 part
In this scheme wherein the part 2 material medicine by weight form can also for:
Radix Scutellariae 6-12 part Herba Artemisiae Scopariae 6-12 part Semen phaseoli radiati 6-12 part Radix Glycyrrhizae 5-10 part
Folium Ilicis 6-12 part carbamazepine 1-2 part
Chinese medicine of the present invention is watered pill, powder, capsule, honey pill agent or electuary.
The present invention treats prosopalgic preparation method of Chinese medicine, comprises the steps:
1) Rhizoma Chuanxiong is 10 parts, and yellow wine soaked stewing profit 5-8 hour for 3 parts, dries, and low baking temperature is fried to yellow but not burnt, standby;
2) Radix Paeoniae Alba is 10 parts, and 60 ° of stewing profits 5-8 hour of pure grain fermentation Chinese liquor are dried, and low baking temperature is fried to yellow but not burnt, standby
3) Colla Cornus Cervi is 10 parts, 1 part of pure sesame oil, and roasting processing to crisp, standby;
4) by the proportioning of described part 1 Rhizoma Chuanxiong, the Radix Paeoniae Alba, get described step 1), 2) in standby Rhizoma Chuanxiong, the Radix Paeoniae Alba, reach described part 1 all the other raw material of Chinese medicine except that Rhizoma Chuanxiong, the Radix Paeoniae Alba after screening, cleaning, place extracting cylinder, adding the water heating decocted 5 hours, reclaim volatile oil with the distillation condensation method, extracting solution is condensed into fluid extract;
5) method processing in described part 2 medicine material such as the step 4) is condensed into fluid extract;
6) combining step 4) and 5) fluid extract collected;
7) by the proportioning of Cornu Cervi in described the 3rd part, get Cornu Cervi standby in the described step 3), and through screening, clean, dry back described the 3rd part all the other raw material of Chinese medicine except that Cornu Cervi, pulverizing, 120 mesh sieves;
8) step 7) gained medicated powder is added in the step 6) gained fluid extract, receive the cream mix homogeneously, 60 ℃ of crushed after being dried;
9) sterilize, make the watered pill, dry back extension clothing.
10) before the packing, the volatile oil in the step 4) evenly is sprayed on mix homogeneously on the watered pill, rapidly packing, sealing.
Described extension clothing is a clothing for hanging Margarita powder.
Another kind of preparation method of the present invention is: complete feed is gone in the grinder behind the screening cleaning-drying, grinds, and requires degree of grinding 300-400 order, is prepared into watered pill, powder, capsule, honey pill agent or electuary then; Each oral 3g, curative effect is similar to said method.
Chinese medicine of the present invention can carry out following dosage form can 1) powder; 2) capsule; 3) watered pill; 4) honey pill agent 5) dosage form such as electuary changes.
Trigeminal neuralgia is commonly called as " wind syndrome of head ".The burst of its disease is prominent to be ended, outbreak repeatedly, can be because of wind-engaging, catch cold, the excited or feed of speaking etc. causes outbreak, its painful as acupuncture, lancinate, lightning, severe degree often crush the life out of sb.How dizzy its arteries and veins is, tight, greasy fur, tongue dark or petechia, ecchymosis are arranged, so primary disease and wind, fire, the stasis of blood and body void have substantial connection.It is controlled, must be eliminating evil to search wind, and disperse blood stasis and dredge collateral, the easing the affected liver analgesia is rule of treatment.
We get the Rhizoma Chuanxiong of big agent, and with the property that its hot Wen Xiang scurries, promoting flow of QI and blood reaches the top, mountain peak, down to the sea of blood on the function of dispelling wind and easing pain.Disperse blood stasis and dredge collateral and ease pain and be principal agent.Can the dispel wind of women's head-ornaments of Rhizoma Gastrodiae, Herba Schizonepetae, Fructus Viticis; Herba Asari, the kind wind of searching network of Scolopendra, the Semen Sinapis Albae collateral dredging reduces phlegm, the Rhizoma Cyperi promoting QI circulation for relieving depression, Radix Stephaniae Tetrandrae, Radix Paeoniae Alba spasmolytic, helping Rhizoma Chuanxiong analgesic effect altogether is accessory drugs; Radix Scutellariae, Folium Ilicis heat clearing away, the light clear and soothing liver-QI hepatoprotective of Herba Artemisiae Scopariae, Semen phaseoli radiati, Radix Glycyrrhizae detoxifcation and concoct all medicines are adjuvant drug altogether; Radix Bupleuri, the Radix Angelicae Dahuricae and Radix Puerariae tying-in and be messenger drug.Full side evacuates the collateral dredging of holding concurrently among eliminating evil and opens the stasis of blood, makes heresy that the outlet be arranged, and the light clearly floating product that rise are arranged again among the analgesia, and clearing heat in QI system is risen again, benefit is arranged in rushing down, have in logical hold back, effect is aided it, toxicity can be separated it, complement each other, so be safe person in the analgesia side.
The leading link of this preparation is " activating blood circulation to dissipate blood stasis ", its principal agent Rhizoma Chuanxiong blood-activating and qi-promoting, dispelling wind and removing obstruction in the collateral is the headache key medicine, according to modern pharmacological research, include alkaloid, volatile oil, the sedation of alleviating pain is arranged, can do and be used for cental system, regulate the pain sensation maincenter of brain and bring into play analgesic effect, because of its promoting flow of QI and blood function, when releasing blood is restricted and suppress by means of administrative decrees, etc. the nervi trigeminus effect, can improve nervi trigeminus again and support the blood flow state of branch vessel, improve trifacial metabolic processes, neural speckle forms and the myelinoclasis phenomenon is all helpful to improving.So with being principal agent.
With Radix Paeoniae, Radix Glycyrrhizae spasmolytic, Scolopendras etc. are alleviated neural spasm pain, Semen phaseoli radiati replenishes nitro-phosphorus enzyme, all can pass through different approaches, suppress or alleviate the granting of the unusual pain current potential between neurocyte and pain relieving, though and the effect of Chinese medicine is not as the strong of carbamazepine and rapidly, yet because the long-acting of Chinese medicine, as if prevention is more valuable ahead of time.
The Cornu Cervi Radix Angelicae Sinensis, the product of nourishings such as Semen phaseoli radiati, it is amino acid needed to include multiple nervous tissue, vitamin and enzyme material, contained crin albumen in the Cornu Cervi wherein, being in harmony is to prevent the pain conduction in the neuroglia, must protein.More, environment in the nervous system regulation is played an important role because of effects such as its raise immunity.
We reach the requirement of above-mentioned trigeminal neuralgia ideal treatment scheme basically in sum, and primary and secondary is taken into account, and treating both the principal and the secondary aspects of a disease at the same time can be prevented the outbreak of pain fast, can fundamentally recover neural normal physiological function again.It is a kind of Ideal Match mode.
The characteristics of this prescription:
1) the analgesia index is higher, and analgesia is very fast to being worth, and long-acting is arranged.This preparation has changed the simple levigation pill method of conventional Chinese patent medicine, and is decocting, is condensed into the process of extractum, and the biphase bonded technology of medical material of part levigation is arranged.Reclaimed the volatile oil composition in the decocting process, absorb fast and analgesic activity is strong so take this medicine, and the medical material of reserve part levigation can slowly play a role again, it is longer that drug effect is kept.
2) can bring into play the analgesic activity of medicine, can change the intrinsic pathological process of nervous system again, recover the pathological changes nerve and make it the physiological function of bringing into normal play.Combine with effecting a permanent cure so belonging to takes stopgap measures, the complete preparation that topical therapeutic combines with wholistic therapy, the Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling can improve neural blood supply in the side, Radix Angelicae Sinensis and Semen phaseoli radiati contain a large amount of vitamin B complexes, can provide nervous system required necessary material, Cornu Cervi contains more fibroin composition, can replenish the necessary protein of nervous system, can replenish the crude protein in the neuroglia again, and booster immunization function, contain nitro one phosphorus enzyme in the Semen phaseoli radiati, also be to stablize neural irritability, avoid the necessary material of unusual pain sensation current potential, therefore medicine-feeding is share and is strengthened neural immunologic function, strive for that neural demyelinating disease is recovered, it is very important eliminating neural short circuit conduction.
3) accomplish that fully nothing poisons processing, untoward reaction is few.This preparation is by following 3 aspects, and the nothing of having strengthened medicine for oral administration poisons processing, rare toxic and side effects reaction.One: selected nontoxic or lower toxicity medicine is as the main composition part of host.Its two: select always confessed effective detoxifcation medicine-Semen phaseoli radiati and Radix Glycyrrhizae for use, and fry in shallow oil separately and add after soup becomes extractum, detoxicating functions is promptly arranged, do not offset former side's analgesia function again; Its three: to dry, analgesic according to the yin-yang attribute of the major-minor medicine of we with cold with profit, adjust the scorching bias in the prescription, make prescription gentle, to reduce untoward reaction.Such as: use Radix Scutellariae, Folium Ilicis among the we separating the warm of Herba Asari, to separate the dry of Rhizoma Chuanxiong, be all the method for conciliation with the profit of Radix Angelicae Sinensis Semen phaseoli radiati.The three therapeutic methods of traditional Chinese medicine makes toxicity very little altogether in a side, and untoward reaction is few, is fit to very much the long trigeminal neuralgia patient of treatment cycle.
4) this prescription can share with the Western medicine carbamazepine, and plays synergism.As everyone knows, carbamazepine is powerful and rapid to trifacial analgesic activity, the analgesia good merchantable brand of can yet be regarded as, yet because its serious adverse effects, most of patients is forced to drug withdrawal and is ended treatment in treatment.We also find the scorching attribute of carbamazepine in the research detoxification, therefore, use Radix Scutellariae, Herba Artemisiae Scopariae, Semen phaseoli radiati, the combination of Radix Glycyrrhizae four medicines, have offset the scorching bias of carbamazepine.Both are refinforced each other, promptly strengthened analgesic effect, alleviated the side effect of carbamazepine again significantly, the optimum compatibility of can yet be regarded as.
Chinese medicine preparation of the present invention has that the wind of searching is eliminating evil, disperse blood stasis and dredge collateral, easing the affected liver analgesia, nourish the tonification effect, cure mainly trigeminal neuralgia, head and facial neuralgia and angioneurotic headaches such as glossopharyngeal neuralgia, sphenopalatine neuralgia, neuralgia of greater occipital nerve, migraine, tension headache, facial paralysis and facial nerve spasm.
Description of drawings
The best analgesia index percentage rate comparison diagram that occurs when Fig. 1 I, II group treatment beginning one week of back and 4 weeks;
Fig. 2 trigeminal neuralgia cause of disease, pathogenesis, method of treatment and medication sketch map;
Fig. 3 trigeminal neuralgia investigative technique route map;
The specific embodiment
Single medicine processing:
1) Rhizoma Chuanxiong processing technique embodiment:
10 parts of Rhizoma Chuanxiongs, yellow wine soaked stewing profit 5-8 hour altogether for 3 parts, airing, and low baking temperature is fried to yellow, does not make parching to brown.
2) Radix Paeoniae Alba processing technique embodiment:
10 parts of the Radix Paeoniae Albas, Chinese liquor are as 60 ° of pure grain fermented wine, and 3 parts, stewing profit is total to 5-8 hour, airing, and low baking temperature is fried to little Huang, does not make parching to brown.
3) Cornu Cervi processing technique embodiment:
10 parts of Colla Cornus Cervi, 1 part of pure sesame oil, roasting moxibustion are to crisp degree.
Each crude drug of the present invention is formed and proportioning processing:
Raw medicinal material of the present invention is divided into 3 parts.
Part 1:
1.5 parts of 1 part of Semen Sinapis Albaes of 4 parts of Rhizoma Typhoniis of 2 portions of Radix Paeoniae Albas of 6 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong
1 part of 1 part of Fructus Viticis of 1.5 parts of Herba Schizonepetaes of 1.5 parts of Radix Bupleuri of 1 part of Rhizoma Cyperi of Radix Stephaniae Tetrandrae
1 part of Radix Puerariae;
Part 2:
1 part of 1 part of Folium Ilicis of 1.5 portions of Radix Glycyrrhizaes of 1.5 portions of Semen phaseoli radiatis of 1.5 parts of Artemisia anethoicles Mattf of Radix Scutellariae
The 3rd part:
1 part of 1 portion of Scorpio of 1.5 parts of Radixs Angelicae Dahuricae of 2 parts of Rhizoma Corydalis of 2 parts of Herba Asaris of Rhizoma Gastrodiae
0.5 part of 0.5 part of Margarita of 1.5 parts of Cornu Cervis of 0.5 portion of Bombyx Batryticatus of Scolopendra.
Concentrated watered pill processing technique of the present invention:
A) with step 1), 2) standby 4 parts of 6 parts of Rhizoma Chuanxiongs, the Radix Paeoniae Albas and place extracting cylinder through screening, all the other part 1 raw material of Chinese medicine except that Rhizoma Chuanxiong, the Radix Paeoniae Alba of cleaning, adding the water post-heating decocted 5 hours, reclaim volatile oil with the distillation condensation method, extracting solution is condensed into fluid extract;
B) part 2 raw material of Chinese medicine processing is as A) be condensed into fluid extract;
C) merge A) and B) gained fluid extract;
D) pulverize with 0.5 part on Cornu Cervi standby in the step 3) and through screening, cleaning, dried all the other except that Cornu Cervi the 3rd part raw material of Chinese medicine, cross 120 mesh sieves.
E) with step D) preparation medicated powder add C) in the gained fluid extract, receive the cream mix homogeneously, 60 ℃ of crushed after being dried.
F) sterilizing, make the watered pill, dry back, to hang Margarita powder be clothing.
G) before the packing, with steps A) in the volatile oil that obtains evenly be sprayed on mix homogeneously on the watered pill, packing, sealing rapidly.
The processing technique of Tang's technology is ground in application:
Directly the 1st, 2,3 part raw material of Chinese medicine complete feeds are gone in the grinder behind the screening cleaning-drying, grind, require degree of grinding 300-400 order, make powder.Instructions of taking: each oral 3g.
Embodiment 2: each crude drug of the present invention consists of:
Part 1:
3 parts of 12 parts of Rhizoma Typhoniis of 6 portions of Radix Paeoniae Albas of 18 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong
4.5 parts of 4.5 parts of Radix Bupleuri of 3 parts of Rhizoma Cyperi of 4.5 parts of Radixs Stephaniae Tetrandrae of Semen Sinapis Albae
3 parts of 3 parts of Radix Puerariaes of 3 parts of Fructus Viticises of mustard fringe
Part 2:
3 parts in 3 portions of Radix Glycyrrhizaes of 3 portions of Semen phaseoli radiatis of 3 portions of Herba Artemisiae Scopariaes of Radix Scutellariae
1.5 parts of Folium Ilicis
The 3rd part:
3 parts of 4.5 parts of Radixs Angelicae Dahuricae of 6 parts of Rhizoma Corydalis of 6 parts of Herba Asaris of Rhizoma Gastrodiae, 3 Scorpios
1.5 parts of 1.5 parts of Margaritas of 4.5 parts of Cornu Cervis of 1.5 portions of Bombyx Batryticatus of Scolopendra
Wherein each single medicine Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cornu Cervi processing method are with embodiment 1, and the processing method of concentrated watered pill processing method and application grinding technology is all with embodiment 1.
Embodiment 3:
Part 1:
2 parts of 8 parts of Rhizoma Typhoniis of 4 portions of Radix Paeoniae Albas of 12 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong
3 parts of 3 parts of Radix Bupleuri of 2 parts of Rhizoma Cyperi of 3 parts of Radixs Stephaniae Tetrandrae of Semen Sinapis Albae
2 parts of 2 parts of Radix Puerariaes of 2 parts of Fructus Viticises of mustard fringe
Part 2:
1 part in 1 portion of Radix Glycyrrhizae of 1 portion of Semen phaseoli radiati of 1 portion of Herba Artemisiae Scopariae of Radix Scutellariae
0.5 part of Folium Ilicis
The 3rd part:
2 parts of 3 parts of Radixs Angelicae Dahuricae of 4 parts of Rhizoma Corydalis of 4 parts of Herba Asaris of Rhizoma Gastrodiae, 2 Scorpios
1 part of 1 part of Margarita of 3 parts of Cornu Cervis of 1 portion of Bombyx Batryticatus of Scolopendra
Wherein each single medicine Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cornu Cervi processing method are with embodiment 1, and the processing method of concentrated watered pill processing method and application grinding technology is all with embodiment 1.
Embodiment 4:
Each crude drug of the present invention consists of:
Part 1:
2 parts of 8 parts of Rhizoma Typhoniis of 4 portions of Radix Paeoniae Albas of 12 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong
3 parts of 3 parts of Radix Bupleuri of 2 parts of Rhizoma Cyperi of 3 parts of Radixs Stephaniae Tetrandrae of Semen Sinapis Albae
2 parts of 2 parts of Radix Puerariaes of 2 parts of Fructus Viticises of mustard fringe
Part 2:
5 parts in 6 portions of Radix Glycyrrhizaes of 6 portions of Semen phaseoli radiatis of 6 portions of Herba Artemisiae Scopariaes of Radix Scutellariae
1 part of 6 parts of carbamazepine of Folium Ilicis
The 3rd part:
2 parts of 3 parts of Radixs Angelicae Dahuricae of 4 parts of Rhizoma Corydalis of 4 parts of Herba Asaris of Rhizoma Gastrodiae, 2 Scorpios
1 part of 1 part of Margarita of 3 parts of Cornu Cervis of 1 portion of Bombyx Batryticatus of Scolopendra
Wherein each single medicine Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cornu Cervi processing method are with embodiment 1, except that 1 part of carbamazepine is not participated in the preparation of part 2 fluid extract, all the other each several part crude drug processing methods are with embodiment 1, and carbamazepine is in step e) in each several part medicated powder mix homogeneously.The concentrated watered pill processing method, and the processing method of application grinding technology is with embodiment 1.
Embodiment 5:
Patient Wang, man 56 years old, the dynamo-electric workman of factory in certain city.The facial ictal lightning sample severe pain in left side 3 years, there is not any inducement burst lower tooth severe pain, rate connects lower lip, inclined to one side side of tongue and buccal, naturally pacifying after upward being the lasting 3-5min of lightning sample to the temple place and separate, shows effect 5-10 time since then just like habitually in the past every day in pain outbreak back, all feeds, speak, washing one's face, brushing teeth all can cause outbreak, very painful.Be diagnosed as trigeminal neuralgia through authoritative hospital, often can very fast pain relieving after carbamazepine treatment is taken, the severe vertigo nausea and vomiting takes place but take the back at every turn, finally have no alternative but the carbamazepine of stopping using, and use acupuncture instead, the Radix Schefflerae Arboricolae sheet, and traditional Chinese medical science decoction, alleviate to some extent therebetween, and final pain is as before.Patient's misery of expressing one's feelings when examining dare not be spoken and with hand steered, touched down chin portion with cotton swab and can cause outbreak immediately, and thick fur is greasy.Dark tongue quality and visible petechia ecchymosis, hesitant pulse.Doctor trained in Western medicine is checked: nervous system does not have other positive to be levied, Cranial Computed Tomography inspection, no abnormal finding.Diagnosis: primary trigeminal neuralgia.Traditional Chinese medical science disease type: obstruction of collaterals by blood stasis, turbid damp cohesion type, women's head-ornaments pain.Chinese medicine of the present invention for oral administration, each 3g, avoids all pungent things at every day 2 times.Take medicine after the week, pain degree has alleviated most, can stand during outbreak, and only show effect 3-5 time every day.Check: tongue fur is slightly greasy, stringy pulse.Continue to take medicine to January, the patient is in high spirits, can arbitrarily talk, and chin portion no longer causes outbreak under the touching lower lip, advises and obeys a drug withdrawal in month again, through observing not recurrence in a year, the work of normally going to work.
Embodiment 6: the clinical practice of Chinese medicine of the present invention
GP TH by 292 routine primary trigeminal neuralgia cases, observed therapeutic effect, total effective rate 97.4%, the recovery from illness and obvious effective rate be combined into 88%, average course of treatment is 45 days, toxicity is very little, and share with carbamazepine, analgesic effect is better, and can alleviate the toxic and side effects of carbamazepine, plays synergism.Illustrated that Chinese medicine of the present invention is the high and safe pure Chinese medicinal preparation of a kind of curative effect.
Patient forms and grouping:
Constitutional three red neuralgia 292 examples, wherein male 94 examples, women 198 examples, age 33-86 year, the course of disease 3 months-40 years.
Diagnostic criteria:
The position of pain and trigger point: pain is positioned at trifacial any areal area more than 1 or 1, mostly be one-sided with buccal, the inclined to one side side of upper and lower chin and tongue is the most obvious, upper lip is outer, side, the wing of nose, buccal, canine tooth, tongue etc. locate that tangible trigger point can be arranged, and take food, speak, brush teeth, wash one's face and all can bring out.The feature of pain: normal absence of aura, take place suddenly, (as lightning, acupuncture, lancinate or tear, burn sample) pain that of short duration (several seconds or several minutes) is violent, the outbreak intermission is normal fully.Other positive gonosome of impassivity system is levied.And the reason of the face ache that other reason causes except the energy.
The source of case and selection and grouping observational technique:
All case all meets aforementioned diagnostic criteria, and be divided into treatment by Chinese herbs group of the present invention (hereinafter to be referred as I group) by randomization, Chinese medicine of the present invention merges uses carbamazepine group (hereinafter to be referred as the II group), and Radix Schefflerae Arboricolae matched group (hereinafter to be referred as the III group) is used carbamazepine matched group (hereinafter to be referred as the IV group) merely, totally four groups of paired observations, in observation item, except that curative effect is observed, simultaneously to the toxic and side effects of each group, untoward reaction, relapse rate and coefficient of stabilization are observed simultaneously and are followed up a case by regular visits to.
The drug dose instructions of taking and the course of treatment that each group is used.
The I group is used Chinese medicine of the present invention, and is for oral administration, each 3 grams, every day 2 times; The II group is used Chinese medicine of the present invention, and dosage method and I group are identical, adds simultaneously with oral each 0.1 gram of Western medicine Atretol, every day 3 times; The commercially available Chinese light peach sheet of III group application is copied into the watered pill with the same color size of Chinese medicine of the present invention, and same instructions of taking is undertaken by double-blind method; The simple application of IV group Atretol is oral, each 0.1 gram, every day 3 times.
Each organizes the shortest person 7 days course of treatment, elder 3 months, and Chinese drug-treated group average course of treatment 45 days is because of serious adverse reaction drug withdrawal person midway, without exception by invalid statistics.
The intractable headache item criterion that the national traditional Chinese medical science encephalopathy of reference Professional Committee formulates, 1) clinical recovery: pain and other are followed all disappearances of disease, periodicity or repeated relapsing headache, follow up a case by regular visits to no recidivist more than 5 times in time through the long pause phase, or the persistence headache, followed up a case by regular visits to no recidivist through 1 month.2) produce effects: pain and follow disease significantly to alleviate, meet following two persons: A) pain degree alleviates more than 2 grades; B) durante dolors shortens over half; C) pain stage of attack prolongation is more than 1 times; D) simultaneous phenomenon reduces or the person of being clearly better.3) effective: pain and simultaneous phenomenon alleviate to some extent, and meet following two persons: A) pain degree subtracts more than the one-level; B) pain time shortens to some extent; C) the pain outbreak intermission prolongs to some extent; D) simultaneous phenomenon reduces or improvement person to some extent.4) invalid: pain and simultaneous phenomenon all do not have improvement.Curative effect sees Table 1.
Table 1 is respectively organized the curative effect statistical table
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Effectively total | Recovery from illness adds obvious effective rate | ||||||
| ％ | ％ | ％ | |||||||||||
| I | 78 | 42 | 53.8 | 27 | 34.6 | 7 | 9.1 | 2 | 2.6 | 76 | 97.4 | 69 | 88.4 |
| II | 60 | 33 | 55 | 21 | 35 | 5 | 8.3 | 1 | 1.7 | 59 | 98 | 54 | 90 |
| III | 77 | 13 | 17 | 18 | 23 | 28 | 36 | 18 | 24 | 59 | 76 | 31 | 40 |
| IV | 55 | 6 | 11 | 6 | 11 | 23 | 42 | 20 | 36 | 35 | 64 | 12 | 22 |
Treatment group I uses treatment by Chinese herbs 78 examples of the present invention, and clinical recovery 42 examples account for 53.8%; Produce effects 27 examples account for 34.6%; Effective 2 examples account for 2.6%, and total effective 76 examples account for 97.4%, and the sum total that adds produce effects of fully recovering is 69 examples, accounts for 88.4.
Control Group II I uses the Radix Schefflerae Arboricolae treatment, and in 77 examples, clinical recovery 13 examples account for 17%; Produce effects 18 examples account for 23%; Total 59 examples of imitating account for 76%; Produce effects and recovery from illness sum total 31 examples account for 40%.
Matched group IV uses the carbamazepine treatment, recovery from illness 6 examples in 55 examples, and produce effects 6 examples all respectively account for 11%; Effective 23 examples account for 42%; Total effective 35 examples account for 64%; And recovery from illness adds 12 examples that are combined into of produce effects, accounts for 12%.
The I group compares with the III group: X
2=7.99, P＜0.05, Riolt analyzes P＜0.05.Illustrate that the I group obviously is better than the III group, I group and IV group relatively P＜0.01 superiority illustrate that more by obviously Chinese medicine of the present invention has obvious curative effects to primary trigeminal neuralgia.
This has also added up the untoward reaction that takes place in the treatment, and statistical result sees Table 2.
The untoward reaction statistical table that takes place in table 2 treatment
| Group | The example number | Dizzy | Nausea and vomiting | Erythra | Drowsiness bradykinesia | Arrhythmia | Liver function changes | Meter | |
| I | 78 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1.2 |
| II | 60 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 3.3 |
| III | 77 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1.3 |
| IV | 55 | 6 | 3 | 2 | 10 | 4 | 1 | 26 | 47 |
Among the treatment group I 78 examples only 1 example taken place slight dizzy, but still adhere to medication treatment, and multiple untoward reaction has taken place in matched group IV, and because of factors such as severe vertigo are forced to stop nearly 26 examples of therapist, incidence rate 47%, this with roughly similar with domestic and international report, two group difference highly significants, Ridt analyzes P＜0.01, illustrates that Chinese medicine of the present invention significantly is better than carbamazepine.
Organize II even more noteworthy, use Chinese medicine of the present invention and merge application carbamazepine group, the same identical instructions of taking of dosage, and incidence rate of adverse reaction only is 2 examples (3.3%), P＜0.01, having illustrated that effectively Chinese medicine of the present invention has obvious effect to the toxic and side effects of removing or resisting carbamazepine, the synergism that both share also has been described, is a kind of optimum compatibility.
Each organizes the stable curative effect investigation of clinical cure patient after 3 years and 5 years:
Consider that follow up survey takes than length and can cause unavoidable pain example to lose phenomenon, and to the curative effect of medication assessment should be just low not with regard to high science principle, so the investigation of relapse rate is not taked in this group investigation, and employing does not have the coefficient of stabilization investigation method that recurs.The results are shown in Table 3.
Table 3 is cured the stable curative effect situation of case after 3 years and 5 years
| Group | N cures | Cure back 3 years follow-up investigation | Cure back 5 years follow-up investigation | ||||
| Not recurrence example | ％ | Not recurrence | ％ | ||||
| I | 42 | 41 | 25 | 60 | 25 | 23 | 54.7 |
| II | 33 | 31 | 20 | 61 | 19 | 18 | 54.5 |
| III | 13 | 13 | 5 | 238 | 4 | 3 | 23 |
| IV | 6 | 6 | 1 | 17 | 1 | 1 | 17 |
Total 42 examples of curing of treatment group I are followed up a case by regular visits to 41 examples after 3 years, wherein stable curative effect, no any recurrence sign person 25 examples account for 60%; Be 23 examples after 5 years, account for 54.7%.Control Group II I accordingly result is respectively 5 examples, 38% and 4 examples 23%.Matched group IV accordingly result is respectively 1 example, 17% and 1 example, 17%.Treatment group I and matched group significant difference, P＜0.05.Two groups of I, II are roughly the same, no significant difference.
After the treatment beginning, duration that best analgesic effect occurs and incidence rate investigation have used that " numerical grade scale (NRS) and analgesia index are index.The exponential computing formula of easing pain is:
Generation example number and time of each group of record then, and the duration that occurs with the best analgesia of each group index and percentage rate prompting different characteristics of respectively organizing medicine, the results are shown in Table 4 and Fig. 1.
Table 4 I and the best analgesia of II group index generation duration table
| Group | n | Cure back 3 years follow-up investigation | Cure back 5 years follow-up investigation | ||
| ％ | ％ | ||||
| I | 78 | 24 | 35 | 60 | 87 |
| II | 60 | 44 | 81.4 | 48 | 88.5 |
By last table analysis during first week exponential incidence rate of best analgesia be group I 24 examples, account for 35%, and group II 44 examples account for 81.4%; With the II group is excellent, P＜0.05.And the best analgesia index incidence rate when first line is all is group I 60 examples, accounts for 87%, and group II 48 examples account for no significant difference between 88.5%, two group, P＜0.05.It is very fast that the curative effect characteristics of pointing out two groups are that group II analgesic effect occurs, can very fast releasing patient suffering, and long-term efficacy, two groups of no significant differences, Fig. 1 can find out the similarities and differences between two groups intuitively.
Observed Chinese medicine of the present invention in addition and nerve has been damaged the rehabilitative action of symptom.In the 78 routine diseases of group I, there is the indivedual pains example radio frequency of having used in treat in sight to coagulate art and cause cornea paralysis symptom person 6 examples, after with treatment by Chinese herbs 3-4 of the present invention month, recovery is in various degree all arranged, measure the current potential that brings out of its preceding frontalis buccinator muscle through TM2 type electromyogram evoked potentuial measuring system, shorten 0.5～1.5mS incubation period, and the wave amplitude of its action potential improves 0.52mV～1.0mV and illustrates that this preparation damages property to nerve and become bitterly certain rehabilitative action is arranged, and is effective in cure to facial paralysis.
Claims (8)
1. treat prosopalgic Chinese medicine for one kind, it is characterized in that: it is by making by following materials of weight proportions:
Part 1:
Rhizoma Chuanxiong 6-18 part Radix Angelicae Sinensis 2-6 part Radix Paeoniae Alba 4-12 part Rhizoma Typhonii 1-3 part
Semen Sinapis Albae 1.5-4.5 part Radix Stephaniae Tetrandrae 1-3 part Rhizoma Cyperi 1.5-4.5 part Radix Bupleuri 1.5-4.5 part
Mustard fringe 1-3 part Fructus Viticis 1-3 part Radix Puerariae 1-3 part
Part 2:
Radix Scutellariae 1-3 part Herba Artemisiae Scopariae 1-3 part Semen phaseoli radiati 1-3 part Radix Glycyrrhizae 1-3 part
Folium Ilicis 0.5-1.5 part
The 3rd part:
Rhizoma Gastrodiae 2-6 part Herba Asari 2-6 part Rhizoma Corydalis 1.5-4.5 part Radix Angelicae Dahuricae 1-3 part Scorpio 1-3 part
Scolopendra 0.5-1.5 part Bombyx Batryticatus 1.5-4.5 part Cornu Cervi 0.5-1.5 part Margarita 0.5-1.5 part.
2. treat prosopalgic Chinese medicine for one kind, it is characterized in that: it is by making by following materials of weight proportions:
Part 1:
1.5 parts of 1 part of Semen Sinapis Albaes of 4 parts of Rhizoma Typhoniis of 2 portions of Radix Paeoniae Albas of 6 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong
1 part of 1 part of Fructus Viticis of 1.5 parts of Herba Schizonepetaes of 1.5 parts of Radix Bupleuri of 1 part of Rhizoma Cyperi of Radix Stephaniae Tetrandrae
1 part of Radix Puerariae;
Part 2:
1 part of 1 part of Folium Ilicis of 1.5 portions of Radix Glycyrrhizaes of 1.5 portions of Semen phaseoli radiatis of 1.5 portions of Herba Artemisiae Scopariaes of Radix Scutellariae
The 3rd part:
1 part of 1 portion of Scorpio of 1.5 parts of Radixs Angelicae Dahuricae of 2 parts of Rhizoma Corydalis of 2 parts of Herba Asaris of Rhizoma Gastrodiae
0.5 part of 0.5 part of Margarita of 1.5 parts of Cornu Cervis of 0.5 portion of Bombyx Batryticatus of Scolopendra.
3. treat prosopalgic Chinese medicine for one kind, it is characterized in that: it is by making by following materials of weight proportions:
Part 1:
Rhizoma Chuanxiong 6-18 part Radix Angelicae Sinensis 2-6 part Radix Paeoniae Alba 4-12 part Rhizoma Typhonii 1-3 part
Semen Sinapis Albae 1.5-4.5 part Radix Stephaniae Tetrandrae 1-3 part Rhizoma Cyperi 1.5-4.5 part Radix Bupleuri 1.5-4.5 part
Mustard fringe 1-3 part Fructus Viticis 1-3 part Radix Puerariae 1-3 part
Part 2:
Radix Scutellariae 6-12 part Herba Artemisiae Scopariae 6-12 part Semen phaseoli radiati 6-12 part Radix Glycyrrhizae 5-10 part Folium Ilicis 6-12 part
The 3rd part:
Rhizoma Gastrodiae 2-6 part Herba Asari 2-6 part Rhizoma Corydalis 1.5-4.5 part Radix Angelicae Dahuricae 1-3 part Scorpio 1-3 part
Scolopendra 0.5-1.5 part Bombyx Batryticatus 1.5-4.5 part Cornu Cervi 0.5-1.5 part Margarita 0.5-1.5 part.
One kind the treatment prosopalgic Chinese medicine, its feature it by making by following materials of weight proportions:
Part 1:
Rhizoma Chuanxiong 6-18 part Radix Angelicae Sinensis 2-6 part Radix Paeoniae Alba 4-12 part Rhizoma Typhonii 1-3 part
Semen Sinapis Albae 1.5-4.5 part Radix Stephaniae Tetrandrae 1-3 part Rhizoma Cyperi 1.5-4.5 part Radix Bupleuri 1.5-4.5 part
Mustard fringe 1-3 part Fructus Viticis 1-3 part Radix Puerariae 1-3 part
Part 2:
Radix Scutellariae 6-12 part Herba Artemisiae Scopariae 6-12 part Semen phaseoli radiati 6-12 part Radix Glycyrrhizae 5-10 part Folium Ilicis 6-12 part carbamazepine 1-2 part.
The 3rd part:
Rhizoma Gastrodiae 2-6 part Herba Asari 2-6 part Rhizoma Corydalis 1.5-4.5 part Radix Angelicae Dahuricae 1-3 Scorpio 1-3 part
Scolopendra 0.5-1.5 part Bombyx Batryticatus 1.5-4.5 part Cornu Cervi 0.5-1.5 part Margarita 0.5-1.5 part.
5. one kind as claim 1,2,3,4 described Chinese medicines, it is characterized in that this Chinese medicine is watered pill, powder, capsule, honey pill agent or electuary.
6. claim 1,2, the prosopalgic preparation method of Chinese medicine of 3 or 4 described a kind of treatments is characterized in that this method comprises the steps:
1) Rhizoma Chuanxiong is 10 parts, and yellow wine soaked stewing profit 5-8 hour for 3 parts, dries, and low baking temperature is fried to yellow but not burnt, standby;
2) Radix Paeoniae Alba is 10 parts, and 60 ° of stewing profits 5-8 hour of pure grain fermentation Chinese liquor are dried, and low baking temperature is fried to yellow but not burnt, standby;
3) Colla Cornus Cervi is 10 parts, 1 part of pure sesame oil, and roasting processing to crisp, standby;
4) by the proportioning of described part 1 Rhizoma Chuanxiong, the Radix Paeoniae Alba, get described step 1), 2) in standby Rhizoma Chuanxiong, the Radix Paeoniae Alba, reach described part 1 all the other raw material of Chinese medicine except that Rhizoma Chuanxiong, the Radix Paeoniae Alba after screening, cleaning, place extracting cylinder, adding the water heating decocted 5 hours, reclaim volatile oil with the distillation condensation method, extracting solution is condensed into fluid extract;
5) method processing in described part 2 medicine material such as the step 4) is condensed into fluid extract;
6) combining step 4) and 5) fluid extract collected;
7) by the proportioning of Cornu Cervi in described the 3rd part, get Cornu Cervi standby in the described step 3), and through screening, clean, dry back described the 3rd part all the other raw material of Chinese medicine except that Cornu Cervi, pulverizing, 120 mesh sieves;
8) step 7) gained medicated powder is added in the step 6) gained fluid extract, receive the cream mix homogeneously, 60 ℃ of crushed after being dried;
9) sterilize, make the watered pill, dry back extension clothing;
10) before the packing, the volatile oil in the step 4) evenly is sprayed on mix homogeneously on the watered pill, rapidly packing, sealing.
7. one kind as preparation method of Chinese medicine as described in the claim 6, it is characterized in that described extension clothing is a clothing for hanging Margarita powder.
8. one kind as preparation method of Chinese medicine as described in the claim 1,2,3,4, and it is characterized in that: complete feed is gone in the grinder behind the screening cleaning-drying, grinds, and requires degree of grinding 300-400 order, is prepared into watered pill, powder, capsule, honey pill agent or electuary then.
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| CN100352486C (en) * | 2005-05-14 | 2007-12-05 | 许志炎 | Headache treating Chinese medicine and its preparation method |
| CN101129727B (en) * | 2007-08-23 | 2010-06-30 | 许光霞 | Orally taken traditional Chinese medicine composition for treating intercostal neurodynia |
| CN102139064B (en) * | 2011-03-29 | 2012-07-25 | 赵明玉 | Chinese patent medicine for preventing and treating angioneurotic headache |
| CN102908473B (en) * | 2012-09-27 | 2016-03-16 | 陈文忠 | One utilizes Radix seu Caulis Kadsurae Heteroclitae to treat prosopalgic Chinese medicine preparation |
| CN103191286B (en) * | 2013-03-07 | 2014-07-09 | 崔夕军 | Traditional Chinese medicine for treating temporomandibular disorders |
| CN103704396B (en) * | 2013-12-09 | 2015-05-13 | 边秋果 | Health care tea for benefiting heart and brain and preparation method thereof |
| CN105395903A (en) * | 2014-04-19 | 2016-03-16 | 刘耿熙 | Preparation method of traditional Chinese medicinal preparation sugar-containing granule for treating prosopalgia |
| CN104857209A (en) * | 2015-06-15 | 2015-08-26 | 刘珍 | Traditional Chinese medicine composition for treating glossopharyngeal neuralgia |
| CN105079342A (en) * | 2015-09-06 | 2015-11-25 | 付丽娜 | External preparation for treating prosopalgia and preparation method |
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