CN101032540A - Medicine composition for curing arthritis and the preparing method and purpose thereof - Google Patents
Medicine composition for curing arthritis and the preparing method and purpose thereof Download PDFInfo
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Abstract
The present invention provides one kind of medicine composition for treating arthritis and its preparation process and use, and the medicine composition is prepared with bone of Myospalax baileyi Thomas 2-8 weight portions, snow lotus 2-7 weight portions, and safflower 0.5-3 weight portions. The medicine composition has synergistic effect and optimized material combination. It is used in treating rheumatic arthritis, rheumatoid arthritis, protrusion of lumbar intervertebral disc and gout, and has determined curative effect and high safety.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treatment of arthritis, particularly, relating to a kind of is the pharmaceutical composition that feedstock production forms with the natural drug.
Background technology
Rheumatic arthritis is the modal a kind of clinical manifestation of rheumatic fever, and is relevant with the allergy that A group hemolytic streptococcal infection causes.This disease onset is more anxious, and the joint of getting involved is again based on big joint.Aspirin can be treated rheumatic arthritis, each 0.9～1.2 gram of taking dose, and every day 3 times, one after each meal, can be bitten tablet under the posterior phraynx into pieces 4～6 weeks of the course of treatment in order to reduce the stimulation of aspirin to stomach.Take in the process of aspirin and need regularly look into prothrombing time and transaminase, have bleeding tendency to add and use vitamin K.The person can select diclofenac for use can not to tolerate the aspirin, and 25～50 milligrams, every day 3 times; Or select naproxen for use, 0.375 restrains every day 2 times; Or select other non-hormone anti-inflammatory agent for use.In order to remove the influence of streptococcal infection, their early stage was advocated and with penicillin 800,000 units, intramuscular injection, every day 2-3 time, the 10-14 days course of treatment.To the penicillin anaphylaxis person, can use erythromycin or acetylspiramycin instead.Rheumatoid arthritis claims rheumatoid (RA) again, is the chronic systemic inflammatory disease that a kind of cause of disease is not understood as yet, is main clinical manifestation with pathological changes outside chronic, symmetry, many synovial jointss inflammation and the joint, belongs to the autoimmune inflammatory diseases.Rheumatoid arthritis does not still have specific short so far, still stays in the treatment to inflammation and sequela, takes Comprehensive Treatment, and most of patients all can obtain certain curative effect.The purpose of existing treatment is: 1. control the inflammation of joint and other tissue, relief of symptoms; 2. keep function of joint and prevent deformity; 3. repair impaired joint to ease the pain and restore funcitons.Mainly being based on Western medicine at arthritic treatment at present, mainly is with relief of symptoms.But the Western medicine side effect is bigger, adopt natural drug at present, especially more at the report of national medication treatment of arthritis, as CN99115965.9, denomination of invention: pharmaceutical composition of treatment of arthritis and osteoarthritis and preparation method thereof, pharmaceutical composition of a kind of treatment of arthritis and osteoarthritis and preparation method thereof is disclosed, it be by following raw materials in percentage by weight routinely formulation method make medicament: Bailey Myospalax Born 30-80% Herba Saussureae Involueratae 20-70%.Said composition comprise Bailey Myospalax Born, Herba Saussureae Involueratae routinely formulation method make medicament; Its preparation method is Bailey Myospalax Born, Herba Saussureae Involueratae to be pulverized back water carry, water intaking extract preparation process is routinely made medicament, but the total effective rate of this invention dispelling cold and removing dampness, liver and kidney tonifying, treatment osteoarthritis and osteoarthritis reaches more than 90.33%, no side effects, safe in utilization.But because the complicated component of medical material, different material consumption and compatibility difference, at the indication difference, the method for treatment rule of treatment is also inequality.
Summary of the invention
Technical problem to be solved by this invention is: the pharmaceutical composition that a kind of treatment of arthritis is provided.
Particularly, the medicine of treatment of arthritis of the present invention is given compound, and it is the medicament that is prepared from by the following weight proportion raw material: 2～8 parts of Bailey Myospalax Born, 2～7 parts of Herba Saussureae Involuerataes, 0.5～3 part on Flos Carthami.
Preferred further, it is the medicament that is prepared from by the following weight proportion raw material: 4～6 parts of Bailey Myospalax Born, 3～6 parts of Herba Saussureae Involuerataes, 0.8～1.5 part on Flos Carthami.
Preferred further, it is the medicament that is prepared from by the following weight proportion raw material: 4.5～5.5 parts of Bailey Myospalax Born, 3.5～5 parts of Herba Saussureae Involuerataes, 0.8～1.1 part on Flos Carthami.
Further preferred, it is the medicament that is prepared from by the following weight proportion raw material: 5 parts of Bailey Myospalax Born, 4 parts of Herba Saussureae Involuerataes, 1 part on Flos Carthami.
Pharmaceutical composition of the present invention is to be active component by the primary crude drug of Bailey Myospalax Born, Herba Saussureae Involueratae, Flos Carthami or water extract or extractive with organic solvent, adds the medicament that acceptable accessories or complementary composition are prepared from.
Wherein, medicament is meant tablet, capsule, granule, pill or oral liquid.It all is conventional adjuvants of these preparations of preparation that the adjuvant of above-mentioned preparation is selected.
Another technical problem to be solved by this invention is: this preparation of drug combination method is provided.
This preparation of drug combination method of the present invention, it comprises the steps:
A, take by weighing the following weight proportion raw material: 2～8 parts of Bailey Myospalax Born, 2～7 parts of Herba Saussureae Involuerataes, 0.5～3 part on Flos Carthami;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract or ethanol extraction, extract;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, decoct with water and extract or ethanol extraction, extract;
D, get b, c step extract and mix, add the medicament that acceptable accessories or complementary composition are prepared from.
The 3rd technical problem to be solved by this invention is: the new purposes that this pharmaceutical composition is provided.
Be the purposes of pharmaceutical composition of the present invention in the medicine of preparation treatment of arthritis.Further, described arthritis is rheumatic arthritis or rheumatoid arthritis.
The present invention also provides the purposes of this pharmaceutical composition in the medicine of preparation treatment prolapse of lumbar intervertebral disc and gout.
Pharmaceutical composition of the present invention have dispel the wind, the effect of dehumidifying, cold expelling, removing obstruction in the collateral to relieve pain, be mainly used in that rheumatic Bi syndromes such as rheumatism and rheumatoid arthritis, osteoarthritis, spasm of the limbs, half body action are ineffective, lumbago and skelalgia, arthralgia, rheumatism of muscles, old body void, walking hardship, lumbar muscle strain and prolapse of lumbar intervertebral disc, gout etc.
Pharmaceutical composition material choice of the present invention and compatibility are to be exopathogen retardance meridians at main pathogenesis, QI-blood circulation is not smooth, so that joint, myalgia, numbness, weighing, joint stuffiness and the arthromyodynia that forms, because the different in kind of being invaded by exogenous pathogen, or inclined to one side victory is arranged, and clinical manifestation is also different, and the inclined to one side victor of ailment said due to cold or exposure is a migratory arthralgia, ailment said due to cold or exposure benefaction and number becomes is so the arthralgia migration is indefinite; The inclined to one side victor of cold-evil is an arthralgia aggravated by cold, cold main spasm, and its property stagnates, so arthralgia has the location; The inclined to one side victor of damp is a damp arthralgia, and is moist heavy sticky, so the articular muscle numbness is weighing swelling.Arthromyodynia is generally three kinds, and the one, with the passing of time arthromyodynia does not heal, and the qi-blood-body fluid operation is not smooth, blood-vessel obstructive, ecchymosis, tuberosity around the joint, cards such as joint stuffiness arthroncus appears, in body fluid cohesion, so that the turbid numbness resistance of blood stasis expectorant meridians.The 2nd, the sick consumption of QI and blood is for a long time hindered, and presents that QI and blood is two loses or the syndrome of deficiency of both the liver and kidney.The 3rd, arthromyodynia more by meridians and internal organs, internal organs numbness do not occur.
Bailey Myospalax Born: see " Qinghai-Tibet medicinal animal ", acrid in the mouth, salty, slightly warm in nature.Dispel the wind, dehumidifying, yellow fluid reducing.The merit of dispersing cold for relieving pain, relaxing muscles and tendons and activating QI and blood in the collateral, strengthening muscles and invigorating stomach, the opposing of increase body is arranged, be used for arthralgia, swelling, joint stuffiness, numbness of the skin, soreness of the waist and knees that anemofrigid-damp arthralgia causes.Herba Saussureae Involueratae, Tibetan medicine just fruit by name Soviet Union clings to, and the effect of detoxifcation, dehumidifying is arranged, " brilliant pearl book on Chinese herbal medicine " record, treatment head sore, anthrax, rheumatism.Flos Carthami, the Tibetan medicine name: Gou Ri Gou Mu, heat clearing and blood circulation promoting, nourishing cure mainly red crust and grand sick.Flos Carthami: warm in nature, acrid in the mouth, Compendium of Material Medica is put down in writing the effect of its tool " invigorate blood circulation, moisturize, pain relieving, loose swollen, dysmenorrhea ".Medicine of the present invention uses this three flavors material combination, and Herba Saussureae Involueratae is heat-clearing and toxic substances removing, reducing swelling and alleviating pain, strongly invigorating primordial QI, nervous system disease in the side.Swelling and pain that arthritis, gout etc. is caused have better curative effect; There is better curative effect Flos Carthami promoting blood circulation to restore menstrual flow, blood stasis dispelling analgesia, hemostasis, nourishing the liver aspect; Rheumatism that Bailey Myospalax Born causes anemofrigid-damp arthralgia and rheumatoid arthritis, osteoarthritis, joint stuffiness, numb limbs and tense tendons, walking hardship have better curative effect.All medicines share, and gout, arthritis that " swelling ", " red crust ", " Baconic ", " yellow fluid " etc. are caused are effective.Be applicable to rheumatic Bi syndromes such as rheumatism and rheumatoid arthritis, arthroncus, heating, pains and other diseases.
Pharmaceutical composition and CN99115965.9 according to the present invention, denomination of invention: the disclosed medicine contrast test of pharmaceutical composition of treatment of arthritis and osteoarthritis and preparation method thereof gained, pharmaceutical composition of the present invention is compared with the disclosed medicine of CN99115965.9 has significant difference, and the effect of treatment of arthritis obviously is better than CN99115965.9.Pharmaceutical composition material combination of the present invention uses, the effect of performance Synergistic, and filter out optimum feed stock and raw material consumption proportion, for treatment rheumatic arthritis, rheumatoid arthritis, gout, drug effect is clear and definite, owing to adopt the pure natural medical material, safe, provide a kind of new selection for clinical.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 500g, Herba Saussureae Involueratae 400g, Flos Carthami 100g;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract 2 times, add 10 times of water gagings at every turn, each decocting time was respectively 8 hours, 4 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, decoct with water and extract 2 times, add 8 times of water gagings at every turn, each decocting time 2 hours, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and loads capsule, capsule of the present invention.
The preparation of embodiment 2 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 800g, Herba Saussureae Involueratae 700g, Flos Carthami 300g;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract three times, add 10 times of water gagings at every turn, each decocting time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, decoct with water and extract three times, add 8 times of water gagings at every turn, each decocting time 2 hours, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and loads capsule, capsule of the present invention.
The preparation of embodiment 3 pharmaceutical composition tablets of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 200g, Herba Saussureae Involueratae 200g, Flos Carthami 50g;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract three times, add 10 times of water gagings at every turn, each decocting time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, decoct with water and extract three times, add 8 times of water gagings at every turn, each decocting time 2 hours, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, sieve, tabletting, tablet of the present invention.
The preparation of embodiment 4 drug composition oral liquid of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 600g, Herba Saussureae Involueratae 600g, Flos Carthami 150g;
B, get Bailey Myospalax Born and pulverize, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 6 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, add 50% ethanol extraction three times, add 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, add entry and correctives, be prepared into oral liquid.
The preparation of embodiment 5 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 400g, Herba Saussureae Involueratae 300g, Flos Carthami 80g;
B, get Bailey Myospalax Born and pulverize, 75% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, add 75% ethanol extraction three times, add 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and loads capsule, promptly.
The preparation of embodiment 6 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 500g, Herba Saussureae Involueratae 400g, Flos Carthami 100g;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract 3 times, add 10 times of water gagings at every turn, each decocting time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, decoct with water and extract 3 times, add 8 times of water gagings at every turn, each decocting time 2 hours, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, pulverize, drying is granulated, and sieves, and loads capsule.
The preparation of embodiment 7 drug composition oral liquid of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 600g, Herba Saussureae Involueratae 600g, Flos Carthami 150g;
B, get Sialon bone meal, 75% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 6 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 75% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, add entry and correctives, be prepared into oral liquid.
The preparation of embodiment 8 drug composition oral liquid of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 600g, Herba Saussureae Involueratae 600g, Flos Carthami 150g;
B, get Bailey Myospalax Born and pulverize, 60% ethanol extraction three times adds 10 times of amount ethanol at every turn, and each extraction time was respectively 6 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 60% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, add entry and correctives, be prepared into oral liquid.
The preparation of embodiment 9 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 400g, Herba Saussureae Involueratae 300g, Flos Carthami 80g;
B, get Bailey Myospalax Born and pulverize, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and is directly encapsulated, promptly.
The preparation of embodiment 10 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 400g, Herba Saussureae Involueratae 300g, Flos Carthami 80g;
B, get Bailey Myospalax Born and pulverize, 65% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 75% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, spray drying, directly encapsulated, promptly.
The preparation of embodiment 11 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 400g, Herba Saussureae Involueratae 300g, Flos Carthami 80g;
B, get Bailey Myospalax Born and pulverize, 60% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 60% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and loads capsule, promptly.
The preparation of embodiment 12 drug composition oral liquid of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 600g, Herba Saussureae Involueratae 600g, Flos Carthami 150g;
B, get Bailey Myospalax Born and pulverize, 65% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 6 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 65% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, add entry and correctives, be prepared into oral liquid.
The preparation of embodiment 13 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 450g, Herba Saussureae Involueratae 500g, Flos Carthami 110g;
B, get Bailey Myospalax Born and pulverize, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and is directly encapsulated, promptly.
The preparation of embodiment 14 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 550g, Herba Saussureae Involueratae 350g, Flos Carthami 80g;
B, get Bailey Myospalax Born and pulverize, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and is directly encapsulated, promptly.
The preparation of embodiment 15 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 450g, Herba Saussureae Involueratae 450g, Flos Carthami 100g;
B, get Bailey Myospalax Born and pulverize, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and is directly encapsulated, promptly.
The preparation of embodiment 16 medicament composition capsule agent of the present invention
A, take by weighing the raw material of following weight: Bailey Myospalax Born 520g, Herba Saussureae Involueratae 350g, Flos Carthami 110g;
B, get Bailey Myospalax Born and pulverize, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, and each extraction time was respectively 8 hours, 4 hours, 2 hours, extract, be condensed into extractum;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, 50% ethanol extraction three times adds 8 times of amount ethanol at every turn, each 2 hours extraction times, 1 hour, 1 hour, extract, be condensed into extractum;
D, get b, c step extract and mix, drying is pulverized, and sieves, and is directly encapsulated, promptly.
The beneficial effect of pharmaceutical composition of the present invention below is described by several typical tests of pesticide effectiveness.
Below the used drugs compared of test is:
1, A group: Bailey Myospalax Born, Herba Saussureae Involueratae extract
A, take by weighing the raw material of following weight: Bailey Myospalax Born 500g, Herba Saussureae Involueratae 500g;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract 2 times, add 10 times of water gagings at every turn, each decocting time was respectively 8 hours, 4 hours, extracting solution;
C, get Herba Saussureae Involueratae, decoct with water and extract 2 times, add 8 times of water gagings at every turn, each decocting time 2 hours, 1 hour, extracting solution;
D, blend step b, c gained extracting solution also are condensed into extractum, promptly.
2, B group: Bailey Myospalax Born, Herba Saussureae Involueratae, Flos Carthami extract
A, take by weighing the raw material of following weight: Bailey Myospalax Born 500g, Herba Saussureae Involueratae 400g, Flos Carthami 100g;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract 2 times, add 10 times of water gagings at every turn, each decocting time was respectively 8 hours, 4 hours, extracting solution;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, decoct with water and extract 2 times, add 8 times of water gagings at every turn, each decocting time 2 hours, 1 hour, extracting solution;
D, blend step b, c gained extracting solution also are condensed into extractum, promptly.
3, positive control: WANGBI CHONGJI (Benxi, Liaoning the 3rd pharmaceutical factory) main component is: Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Dipsaci, Radix Aconiti Lateralis Preparata (system), Radix Angelicae Pubescentis, Rhizoma Drynariae, Ramulus Cinnamomi, Herba Epimedii, Radix Saposhnikoviae, Radix Clematidis, Spina Gleditsiae, Os Caprae seu Ovis, the Radix Paeoniae Alba, Rhizoma Cibotii (system), the Rhizoma Anemarrhenae, Herba Lycopodii, Flos Carthami etc.
4, blank: normal saline.
One. to the therapeutical effect of rat formaldehyde " arthritis ":
[materials and methods]
1, laboratory animal: 32 of Wistar male rats, body weight 180 ± 20g.
2, experimental technique: oral administration gavage administration; Select 32 of Wistar male rats, body weight 180 ± 20g is divided into four groups at random, and promptly blank group (normal saline), positive controls (WANGBI CHONGJI), A group (Bailey Myospalax Born, Herba Saussureae Involueratae), B organize (Bailey Myospalax Born, Herba Saussureae Involueratae, Flos Carthami); To the right back ankle joint implantation concentration of rat is 2.5% formalin 0.1ml, begins administration behind the 1h, 2 times/day, continuous six days, observes and respectively organizes the result.
[experimental result] sees Table 1
The contrast test of the therapeutical effect of table 1 pair rat formaldehyde " arthritis " (X ± SD)
| Group | n | Dosage (g/kg) | Paw swelling (mm/h) | ||||
| 1 | 3 | 5 | 24 | 48 | |||
| Blank positive A group B group | 8 8 8 8 | 1 1 1.5 1.5 | 2.93±0.20 2.63±0.19 2.65±0.17 2.04±0.22 * | 3.43±0.16 2.94±0.23 2.90±0.21 2.34±0.19 * | 4.18±0.24 3.53±0.19 3.47±0.24 2.57±0.20 * | 4.25±0.24 3.78±0.19 3.88±0.23 2.38±0.18 * | 3.82±0.16 2.83±0.15 2.24±0.17 1.69±0.19 * |
[conclusion] result show, relatively respectively organizing with the blank group all has better effect; The B group is significantly higher than A group and positive group (P＜0.01), and onset time is the fastest.
Two. to the inhibitory action of mouse writhing reaction:
[materials and methods]
1, laboratory animal: 40 of Kunming mouses, male and female half and half, body weight 20 ± 2g.
2, experimental technique: oral administration gavage administration; Select 40 of Kunming mouses, male and female half and half, are divided into four groups at random at body weight 20 ± 2g, and promptly blank group (normal saline), positive controls (WANGBI CHONGJI), A group (Bailey Myospalax Born, Herba Saussureae Involueratae), B organize (Bailey Myospalax Born, Herba Saussureae Involueratae, Flos Carthami); 9 of that mornings of experiment are administered once, and 1h respectively organizes mouse peritoneal and injects 1% acetic acid solution (0.3ml/ only) behind afternoon 2 rechallenges, respectively organizes the mouse writhing number of times in the counting 15min behind the 20min.
[experimental result] sees Table 2
The inhibiting contrast test of table 2 pair mouse writhing reaction (X ± SD)
| Group | n | Dosage (g/kg) | 15min turns round the body number of times | Suppression ratio (%) |
| Blank positive A group B group | 10 10 10 10 | 1 1 1.5 1.5 | 324 215 146 127 | / 37.56±2.64 58.12±2.18 * 63.52±2.65 *# |
[conclusion] result show, the analgesic activity that A, B are two groups is significantly higher than positive group (P＜0.01); The analgesic activity of B group is apparently higher than A group (P＜0.05), and onset time is the fastest.
Three. to the influence of mice swimming time, serum urea nitrogen and blood lactic acid content:
[materials and methods]
1, laboratory animal: Kunming mouse
2, experimental technique: select 108 of Kunming mouses, male and female half and half, are divided into nine groups at random at body weight 20 ± 2g, and per three groups is a collection of, and each batch divides a blank group (normal saline), A group (Bailey Myospalax Born, Herba Saussureae Involueratae), B to organize (Bailey Myospalax Born, Herba Saussureae Involueratae, Flos Carthami); Continuously gastric infusion is after 14 days, gives in last to begin to test and measure each index after wanting 30min.
A. swimming test: behind first last administration 30min, to mice bear a heavy burden (loading weight be body weight 5%), mice is put in depth of water 30cm, water temperature (22 ± 0.5) ℃ the swimming case, record begins can not emerge time of (death) as its swimming time to the whole submergeds of head from swimming; The results are shown in Table 3.
B. the mensuration of serum urea nitrogen: behind second crowd of last administration 30min, mice is put in the swimming case of water temperature (22 ± 0.5) ℃ behind the swimming 80min rest 40min, pluck eyeball then and get blood, after the separation, get upper serum, measure blood urea nitrogen with blood urea nitrogen test kit (Diacetylmonoxime method); The results are shown in Table 4.
C. behind the 3rd crowd of last administration 30min of blood determination of lactic acid, be put in the swimming case of water temperature (22 ± 0.5) ℃ and take out behind the swimming 10min, each 20 μ l that take a blood sample, 20 μ l once more take a blood sample behind the quiet 20min, each blood system of adopting is not put into the hemolytic agent of 40 μ l, after the vibration evenly, get supernatant and measure lactic acid; The results are shown in Table 5.
[experimental result] sees Table 3,4,5.
The contrast test of table 3 pair mice swimming time amount influence (X ± SD)
| Group | n | Dosage (g/kg) | Swimming time (s) |
| Blank A group B group | 12 12 12 | 1.5 1.5 | 269±72 332±102 * 384±90 *# |
The contrast test of table 4 pair serum urea nitrogen content influence (X ± SD)
| Group | n | Dosage (g/kg) | Urea nitrogen content (mmol/L) |
| Blank A group B group | 12 12 12 | 1.5 1.5 | 8.89±0.64 8.10±0.79 * 7.96±0.71 *# |
The contrast test of table 5 pair blood lactic acid content influence (X ± SD)
| Group | n | Dosage (g/kg) | Blood lactic acid content (mmol/L) | |
| Motion 10min | Quiet 20min | |||
| Blank A group B group | 12 12 12 | 1.5 1.5 | 23.13±7.02 19.13±3.62 17.93±3.10 * | 20.50±6.65 15.10±3.15 * 14.83±3.31 * |
[conclusion] result show, the swimming time of A, two groups of mices of B is significantly higher than blank group (P＜0.05); The urea nitrogen content of A, two groups of mices of B, blood lactic acid content significantly are lower than blank group (P＜0.05); The swimming time of B group significantly is lower than A group (P＜0.05) apparently higher than A group (P＜0.05), urea nitrogen content, illustrates that the resisting fatigue effect of A group is organized significantly better than B.
Use by pharmacodynamics test proof medicine material compatibility of the present invention, the effect of performance Synergistic, and drug effect and number of patent application: 99115965.9 disclosed preparations are compared, has significant difference, and filter out optimum feed stock and raw material consumption proportion by the test of pesticide effectiveness, the test of pesticide effectiveness and clinical trial proof medicine of the present invention are used for the treatment of rheumatic arthritis, rheumatoid arthritis, prolapse of lumbar intervertebral disc and gout, drug effect is clear and definite, owing to adopt the pure natural medical material, safe, provide a kind of new selection for clinical.
Claims (10)
1, a kind of pharmaceutical composition of treatment of arthritis is characterized in that, it is the medicament that is prepared from by the following weight proportion raw material:
2～8 parts of Bailey Myospalax Born, 2～7 parts of Herba Saussureae Involuerataes, 0.5～3 part on Flos Carthami.
2, the pharmaceutical composition of treatment of arthritis according to claim 1 is characterized in that, it is the medicament that is prepared from by the following weight proportion raw material:
4～6 parts of Bailey Myospalax Born, 3～6 parts of Herba Saussureae Involuerataes, 0.8～1.5 part on Flos Carthami.
3, the pharmaceutical composition of treatment of arthritis according to claim 2 is characterized in that, it is the medicament that is prepared from by the following weight proportion raw material:
4.5～5.5 parts of Bailey Myospalax Born, 3.5～5 parts of Herba Saussureae Involuerataes, 0.8～1.1 part on Flos Carthami.
4, the pharmaceutical composition of treatment of arthritis according to claim 3 is characterized in that, it is the medicament that is prepared from by the following weight proportion raw material:
5 parts of Bailey Myospalax Born, 4 parts of Herba Saussureae Involuerataes, 1 part on Flos Carthami.
5, require the pharmaceutical composition of 1～4 each described treatment of arthritis according to claim, it is characterized in that, it is to be active component by the primary crude drug of Bailey Myospalax Born, Herba Saussureae Involueratae, Flos Carthami or water extract or extractive with organic solvent, adds the medicament that acceptable accessories or complementary composition are prepared from.
6, the pharmaceutical composition of treatment of arthritis according to claim 5 is characterized in that: described medicament is tablet, capsule, granule, pill or oral liquid.
7, a kind of method for preparing the pharmaceutical composition of each described treatment of arthritis of claim 1～6, it comprises the steps:
A, take by weighing the following weight proportion raw material: 2～8 parts of Bailey Myospalax Born, 2～7 parts of Herba Saussureae Involuerataes, 0.5～3 part on Flos Carthami;
B, get Bailey Myospalax Born and pulverize, decoct with water and extract or ethanol extraction, extract;
C, get Herba Saussureae Involueratae, Flos Carthami and mix, decoct with water and extract or ethanol extraction, extract;
D, the extract of getting the preparation of b, c step mix, and add the medicament that acceptable accessories or complementary composition are prepared from.
8, the purposes of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment of arthritis.
9, the purposes of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment prolapse of lumbar intervertebral disc.
10, the purposes of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment gout.
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| CN 200610173352 CN101032540A (en) | 2005-12-29 | 2006-12-29 | Medicine composition for curing arthritis and the preparing method and purpose thereof |
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| CN200510022440.8 | 2005-12-29 | ||
| CN 200610173352 CN101032540A (en) | 2005-12-29 | 2006-12-29 | Medicine composition for curing arthritis and the preparing method and purpose thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028325A (en) * | 2007-04-24 | 2007-09-05 | 杨文龙 | Medicinal composition containing sailonggu, and its preparation and quality control |
| CN115300539A (en) * | 2022-08-16 | 2022-11-08 | 西安今正制药有限公司 | Compound sialon capsule, its preparation method and application in rheumatism bone disease |
| CN116251133A (en) * | 2023-01-14 | 2023-06-13 | 西安今正制药有限公司 | Medicine capable of replacing tiger bone for treating rheumatoid diseases and preparation method thereof |
-
2006
- 2006-12-29 CN CN 200610173352 patent/CN101032540A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028325A (en) * | 2007-04-24 | 2007-09-05 | 杨文龙 | Medicinal composition containing sailonggu, and its preparation and quality control |
| CN101028325B (en) * | 2007-04-24 | 2013-05-29 | 杨文龙 | Medicinal composition containing sailonggu, and its preparation and quality detection method |
| CN115300539A (en) * | 2022-08-16 | 2022-11-08 | 西安今正制药有限公司 | Compound sialon capsule, its preparation method and application in rheumatism bone disease |
| CN116251133A (en) * | 2023-01-14 | 2023-06-13 | 西安今正制药有限公司 | Medicine capable of replacing tiger bone for treating rheumatoid diseases and preparation method thereof |
| CN116251133B (en) * | 2023-01-14 | 2024-02-02 | 西安今正制药有限公司 | Pharmaceutical composition and traditional Chinese medicine preparation for treating rheumatism and rheumatoid diseases by using sialon bone |
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