CN1304027C - Bone nourishing and rheumatic treating pills and their preparation - Google Patents
Bone nourishing and rheumatic treating pills and their preparation Download PDFInfo
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- CN1304027C CN1304027C CNB2003101035245A CN200310103524A CN1304027C CN 1304027 C CN1304027 C CN 1304027C CN B2003101035245 A CNB2003101035245 A CN B2003101035245A CN 200310103524 A CN200310103524 A CN 200310103524A CN 1304027 C CN1304027 C CN 1304027C
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Abstract
The present invention discloses a traditional Chinese medicine composition for curing arthralgia, and a preparation method thereof. The traditional Chinese medicine composition contains the effective components of twotoothed achyranthes root, clematis root, psoralea fruit, eucommia bark, pawpaw, hemlock parsley, angelica, white peony alba, paniculate swallowwort root, cassia twig, scorpion, centipede and heterophylly falsestarwort root. The composition of the present invention can be made into granules, tablets, capsules, pills and oral medicinal liquid. The traditional Chinese medicine composition of The present invention has the functions of tonifying the liver and kidney, dispelling cold and removing dampness, and activating meridians to stop pain, and is used for curing rheumatism, liver asthenia syndrome, nephrasthenia syndrome and cold-damp collateral obstructing syndrome; particularly, the traditional Chinese medicine composition has obvious therapeutic effects on arthralgia, inhibited bending and stretching, and bone joint crymodynia.
Description
[invention field]
The present invention relates to a kind of Chinese medicine composition, is a kind of Chinese medicine composition that is used for the treatment of arthralgia, joint stuffiness specifically, the invention still further relates to the preparation method of this Chinese medicine composition.
[background technology]
Disease such as numerous disease such as osteoarthritis, rheumatic arthritis all can influence and destroy skeleton and osteoarthrosis, and cause pain, the degree that pain and osseous tissue are impaired and the weight of disease are relevant, and along with the prolongation of the course of disease, pain and osteoarticular injury meeting aggravate gradually.Therefore arthralgia, periarthritis disease are to perplex people's common disease for many years always, and various age brackets all have generation, and are especially in the majority with middle-aged and elderly people.Medical circle does not also find the Therapeutic Method that solves fully to most of osteopathia at present, but concentrates on the function of analgesic antiphlogistic and reservation joint and muscle.
In view of the medicine and the method that not have at present better effectively to treat arthralgia, so a kind of Chinese medicine for oral administration that can effectively treat arthralgia and have no side effect of demand still.The present invention goes into through animal experiment and clinical verification repeatedly for many years, develops a kind of Chinese medicine composition that can effectively treat arthralgia and have no side effect, thereby has finished the present invention.
[summary of the invention]
Goal of the invention
Purpose of the present invention just provides a kind of Chinese medicine composition that can effectively treat arthralgia.This medicine has the effect of liver and kidney tonifying, dispelling cold and removing dampness and removing obstruction in the collateral to relieve pain, is used for the treatment of arthromyodynia caused by liver and kidney deficiency, cold-damp resistance network disease, and especially the curative effect to arthralgia, joint stuffiness, osteoarthrosis cold and pain is more remarkable.
Another object of the present invention just provides the preparation method of this Chinese medicine composition.
Technical scheme
The object of the present invention is achieved like this:
The present invention treats the Chinese medicine composition of arthralgia, it is characterized in that the preparation raw material (in weight portion) of the contained active component of this Chinese medicine composition is as follows:
Radix Achyranthis Bidentatae 218-307 part Radix Clematidis 218-307 part Fructus Psoraleae 131-217 part
Cortex Eucommiae 131-217 part Fructus Chaenomelis 131-217 part Rhizoma Chuanxiong 218-307 part
Radix Angelicae Sinensis 131-217 part Radix Paeoniae Alba 131-217 part Radix Cynanchi Paniculati 131-217 part
Ramulus Cinnamomi 131-217 part Scorpio 21-88 part Scolopendra 21-88 part
Radix Pseudostellariae 131-217 part
Preferably, medicine material consumption of the present invention is as follows in weight portion:
Radix Achyranthis Bidentatae 240-285 part Radix Clematidis 240-285 part Fructus Psoraleae 153-197 part
Cortex Eucommiae 153-197 part Fructus Chaenomelis 153-197 part Rhizoma Chuanxiong 240-285 part
Radix Angelicae Sinensis 153-197 part Radix Paeoniae Alba 153-197 part Radix Cynanchi Paniculati 153-197 part
Ramulus Cinnamomi 153-197 part Scorpio 21-66 part Scolopendra 21-66 part
Radix Pseudostellariae 153-197 part
More preferably, medicine material consumption of the present invention is as follows by weight:
167 parts of 167 parts of Cortexs Eucommiae of 250 parts of Fructus Psoraleaes of 250 parts of Radix Clematidis of Radix Achyranthis Bidentatae
167 parts of 167 portions of Radix Paeoniae Albas of 250 parts of Radix Angelicae Sinensis of 167 parts of Rhizoma Chuanxiongs of Fructus Chaenomelis
50 parts of 50 parts of Scolopendras of 167 portions of Scorpios of 167 parts of Ramulus Cinnamomi of Radix Cynanchi Paniculati
167 parts of Radix Pseudostellariaes
The source and the effect thereof of the Chinese crude drug that technique scheme is mentioned are as follows:
Radix Achyranthis Bidentatae: be the dry root of amaranthaceous plant Radix Achyranthis Bidentatae, invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Radix Clematidis: be the dry root and rhizome of ranunculaceae plant Radix Clematidis, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
Fructus Psoraleae: be the dry mature fruit of legumes psoraleae, warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.
The Cortex Eucommiae: be the dry bark of the Eucommiaceae plant Cortex Eucommiae, invigorating the liver and kidney, bone and muscle strengthening.
Fructus Chaenomelis: be the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria, suppressing the hyperactive liver Shujin, stomach function regulating removing dampness.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong.
Radix Angelicae Sinensis: for the dry root of umbelliferae angelica, enrich blood and invigorate blood circulation, loosening bowel to relieve constipation.
The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae, suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation.
Radix Cynanchi Paniculati: the dry root and rhizome of asclepiadaceae plant Radix Cynanchi Paniculati, the removing dampness of dispeling the wind, antalgesic-antipruritic.
Ramulus Cinnamomi: be the cinnamomic dry twig of canella, diaphoresis expelling pathogenic factors from muscles, temperature three-way meridian, supporing yang activating QI, the flat gas that spins.
Scorpio: be the dry body of Buthidae animal Scorpio, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Scolopendra: be the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Radix Pseudostellariae: be the dried root of pinkwort Radix Ginseng, replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.
The effective ingredient of Chinese medicine composition of the present invention is according to comprising that the method for following each processing step obtains:
(a) Scorpio and Scolopendra are ground into fine powder, with Fructus Psoraleae and Rhizoma Chuanxiong 60-80 volume % ethanol water heating and refluxing extraction three times, each 1-3 hour, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol;
(b) Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 1-3 hour at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying;
(c) with above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 1-3 hour, collecting decoction, filter and with the aqueous solution merging after the distillation in filtrate and the above-mentioned steps (b), be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2000-3000 rev/min rotating speed centrifugalize, the clear paste of getting in supernatant and the above-mentioned steps (a) merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of the middle volatile oil inclusion complex of above-mentioned steps (b) and the fine powder of Scorpio and Scolopendra again, make various dosage forms with pharmaceutically acceptable carrier or excipient then, promptly obtain Chinese medicine composition of the present invention.
The described concentration of alcohol of step in the above-mentioned preparation method (a) is preferably 70%, preferably make a living by weight 6 times of dose of alcoholic solution consumption; The rotating speed of the described centrifugalize of step (c) is preferably 2500 rev/mins.
Prescription of the present invention is through the above-mentioned steps preparation, can make various pharmaceutical formulations such as granule, capsule, tablet, pill, oral liquid or the like with pharmaceutically acceptable carrier or excipient composition.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms. and these used carriers or excipient all are easy to determine for the those of ordinary skill of pharmaceutical field, also are conspicuous.
Beneficial effect
Chinese medicine composition of the present invention has the effect of liver and kidney tonifying, dispelling cold and removing dampness and removing obstruction in the collateral to relieve pain, be used for the treatment of arthromyodynia caused by liver and kidney deficiency, cold-damp resistance network disease, especially the curative effect to arthralgia, joint stuffiness, osteoarthrosis cold and pain is more remarkable, and has no side effect, and is suitable for taking for a long time.Medicine of the present invention is easy to take, evident in efficacy, be a kind of medicine of ideal treatment cancer pain.
[specific embodiment]
Below in conjunction with specific embodiment the present invention is elaborated.
Embodiment 1: the preparation of granule of the present invention
Radix Achyranthis Bidentatae 250 weight portion Radix Clematidis 250 weight portion Fructus Psoraleaes 167 weight portions
The Cortex Eucommiae 167 weight portion Fructus Chaenomeliss 167 weight portion Rhizoma Chuanxiongs 250 weight portions
The Radix Angelicae Sinensis 167 weight portion Radix Paeoniae Albas 167 weight portion Radix Cynanchi Paniculatis 167 weight portions
Ramulus Cinnamomi 167 weight portion Scorpios 50 weight portion Scolopendras 50 weight portions
Radix Pseudostellariae 167 weight portions
Scorpio and Scolopendra are ground into fine powder, Fructus Psoraleae and Rhizoma Chuanxiong are counted 6 times the 70 volume % ethanol water heating and refluxing extraction three times of crude drug amount in order to weight, each 2 hours, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; With above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 2 hours, collecting decoction, filter and with filtrate and above-mentioned Radix Angelicae Sinensis, aqueous solution after Ramulus Cinnamomi and the Radix Cynanchi Paniculati distillation merges, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2500 rev/mins rotating speed centrifugalize, the clear paste of getting supernatant and above-mentioned Fructus Psoraleae and Rhizoma Chuanxiong merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of above-mentioned volatile oil inclusion complex and the fine powder of Scorpio and Scolopendra again, add the correctives steviosin then and granulate, with the particle drying of preparation, packing.
Embodiment 2: the preparation of granule of the present invention
Radix Achyranthis Bidentatae 218 weight portion Radix Clematidis 218 weight portion Fructus Psoraleaes 131 weight portions
The Cortex Eucommiae 131 weight portion Fructus Chaenomeliss 131 weight portion Rhizoma Chuanxiongs 218 weight portions
The Radix Angelicae Sinensis 131 weight portion Radix Paeoniae Albas 131 weight portion Radix Cynanchi Paniculatis 131 weight portions
Ramulus Cinnamomi 131 weight portion Scorpios 21 weight portion Scolopendras 21 weight portions
Radix Pseudostellariae 131 weight portions
Scorpio and Scolopendra are ground into fine powder, Fructus Psoraleae and Rhizoma Chuanxiong are counted 6 times the 70 volume % ethanol water heating and refluxing extraction three times of crude drug amount in order to weight, each 2 hours, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; With above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 2 hours, collecting decoction, filter and with filtrate and above-mentioned Radix Angelicae Sinensis, aqueous solution after Ramulus Cinnamomi and the Radix Cynanchi Paniculati distillation merges, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2500 rev/mins rotating speed centrifugalize, the clear paste of getting supernatant and above-mentioned Fructus Psoraleae and Rhizoma Chuanxiong merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of above-mentioned volatile oil inclusion complex and the fine powder of Scorpio and Scolopendra again, add the correctives steviosin then and granulate, with the particle drying of preparation, packing.
Embodiment 3: the preparation of granule of the present invention
Radix Achyranthis Bidentatae 307 weight portion Radix Clematidis 307 weight portion Fructus Psoraleaes 217 weight portions
The Cortex Eucommiae 217 weight portion Fructus Chaenomeliss 217 weight portion Rhizoma Chuanxiongs 307 weight portions
The Radix Angelicae Sinensis 217 weight portion Radix Paeoniae Albas 217 weight portion Radix Cynanchi Paniculatis 217 weight portions
Ramulus Cinnamomi 217 weight portion Scorpios 88 weight portion Scolopendras 88 weight portions
Radix Pseudostellariae 217 weight portions
Scorpio and Scolopendra are ground into fine powder, Fructus Psoraleae and Rhizoma Chuanxiong are counted 6 times the 70 volume % ethanol water heating and refluxing extraction three times of crude drug amount in order to weight, each 2 hours, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; With above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 2 hours, collecting decoction, filter and with filtrate and above-mentioned Radix Angelicae Sinensis, aqueous solution after Ramulus Cinnamomi and the Radix Cynanchi Paniculati distillation merges, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2500 rev/mins rotating speed centrifugalize, the clear paste of getting supernatant and above-mentioned Fructus Psoraleae and Rhizoma Chuanxiong merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of above-mentioned volatile oil inclusion complex and the fine powder of Scorpio and Scolopendra again, add the correctives steviosin then and granulate, with the particle drying of preparation, packing.
Embodiment 4: the preparation of capsule of the present invention
Radix Achyranthis Bidentatae 250 weight portion Radix Clematidis 250 weight portion Fructus Psoraleaes 167 weight portions
The Cortex Eucommiae 167 weight portion Fructus Chaenomeliss 167 weight portion Rhizoma Chuanxiongs 250 weight portions
The Radix Angelicae Sinensis 167 weight portion Radix Paeoniae Albas 167 weight portion Radix Cynanchi Paniculatis 167 weight portions
Ramulus Cinnamomi 167 weight portion Scorpios 50 weight portion Scolopendras 50 weight portions
Radix Pseudostellariae 167 weight portions
Scorpio and Scolopendra are ground into fine powder, Fructus Psoraleae and Rhizoma Chuanxiong are counted 6 times the 70 volume % ethanol water heating and refluxing extraction three times of crude drug amount in order to weight, each 2 hours, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; With above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 2 hours, collecting decoction, filter and with filtrate and above-mentioned Radix Angelicae Sinensis, aqueous solution after Ramulus Cinnamomi and the Radix Cynanchi Paniculati distillation merges, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2500 rev/mins rotating speed centrifugalize, the clear paste of getting supernatant and above-mentioned Fructus Psoraleae and Rhizoma Chuanxiong merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mixes evenly with the fine powder of above-mentioned volatile oil inclusion complex and the fine powder of Scorpio and Scolopendra again, incapsulate then.
Embodiment 5: the preparation of tablet of the present invention
Radix Achyranthis Bidentatae 250 weight portion Radix Clematidis 250 weight portion Fructus Psoraleaes 167 weight portions
The Cortex Eucommiae 167 weight portion Fructus Chaenomeliss 167 weight portion Rhizoma Chuanxiongs 250 weight portions
The Radix Angelicae Sinensis 167 weight portion Radix Paeoniae Albas 167 weight portion Radix Cynanchi Paniculatis 167 weight portions
Ramulus Cinnamomi 167 weight portion Scorpios 50 weight portion Scolopendras 50 weight portions
Radix Pseudostellariae 167 weight portions
Scorpio and Scolopendra are ground into fine powder, Fructus Psoraleae and Rhizoma Chuanxiong are counted 6 times the 70 volume % ethanol water heating and refluxing extraction three times of crude drug amount in order to weight, each 2 hours, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; With above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 2 hours, collecting decoction, filter and with filtrate and above-mentioned Radix Angelicae Sinensis, aqueous solution after Ramulus Cinnamomi and the Radix Cynanchi Paniculati distillation merges, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2500 rev/mins rotating speed centrifugalize, the clear paste of getting supernatant and above-mentioned Fructus Psoraleae and Rhizoma Chuanxiong merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of above-mentioned volatile oil inclusion complex and the fine powder of Scorpio and Scolopendra again, make wet granular, tabletting with commonly used excipient of preparation tablet such as starch etc. then.
Embodiment 6: the preparation of pill of the present invention
Radix Achyranthis Bidentatae 250 weight portion Radix Clematidis 250 weight portion Fructus Psoraleaes 167 weight portions
The Cortex Eucommiae 167 weight portion Fructus Chaenomeliss 167 weight portion Rhizoma Chuanxiongs 250 weight portions
The Radix Angelicae Sinensis 167 weight portion Radix Paeoniae Albas 167 weight portion Radix Cynanchi Paniculatis 167 weight portions
Ramulus Cinnamomi 167 weight portion Scorpios 50 weight portion Scolopendras 50 weight portions
Radix Pseudostellariae 167 weight portions
Scorpio and Scolopendra are ground into fine powder, Fructus Psoraleae and Rhizoma Chuanxiong are counted 6 times the 70 volume % ethanol water heating and refluxing extraction three times of crude drug amount in order to weight, each 2 hours, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; With above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 2 hours, collecting decoction, filter and with filtrate and above-mentioned Radix Angelicae Sinensis, aqueous solution after Ramulus Cinnamomi and the Radix Cynanchi Paniculati distillation merges, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2500 rev/mins rotating speed centrifugalize, the clear paste of getting supernatant and above-mentioned Fructus Psoraleae and Rhizoma Chuanxiong merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of above-mentioned volatile oil inclusion complex and the fine powder of Scorpio and Scolopendra again, add refined honey then and make small honey pill or big honeyed pills.
Embodiment 7: oral liquid of the present invention
Radix Achyranthis Bidentatae 250 weight portion Radix Clematidis 250 weight portion Fructus Psoraleaes 167 weight portions
The Cortex Eucommiae 167 weight portion Fructus Chaenomeliss 167 weight portion Rhizoma Chuanxiongs 250 weight portions
The Radix Angelicae Sinensis 167 weight portion Radix Paeoniae Albas 167 weight portion Radix Cynanchi Paniculatis 167 weight portions
Ramulus Cinnamomi 167 weight portion Scorpios 50 weight portion Scolopendras 50 weight portions
Radix Pseudostellariae 167 weight portions
Scorpio and Scolopendra are ground into fine powder, Fructus Psoraleae and Rhizoma Chuanxiong are counted 6 times the 70 volume % ethanol water heating and refluxing extraction three times of crude drug amount in order to weight, each 2 hours, merge extractive liquid, also filters, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol; Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 2 hours at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying; With above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 2 hours, collecting decoction, filter and with filtrate and above-mentioned Radix Angelicae Sinensis, aqueous solution after Ramulus Cinnamomi and the Radix Cynanchi Paniculati distillation merges, be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2500 rev/mins rotating speed centrifugalize, the clear paste of getting supernatant and above-mentioned Fructus Psoraleae and Rhizoma Chuanxiong merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of above-mentioned volatile oil inclusion complex and the fine powder of Scorpio and Scolopendra again, add correctives Mel and diluent water then and make oral liquid.
Below set forth the effect of this Chinese medicine composition by the test of pesticide effectiveness.
Experimental example 1: the clinical trial of Chinese medicine composition of the present invention
The case choice criteria:
1, main clinical manifestation: position pain such as joint, skin, muscles and bones, or swelling, morning stiff numb weight person, or joint stuffiness, person's joint swelling deformation is not very stiffly stretched amyotrophy etc.
2, the osteoarthritis of knee joint position, the X line turns out to be osteoarthritis.
3, the age is at 40-65 between year.
Test method:
1, adopts random packet, counter point.
2, verify routine number: 60 examples are organized in treatment, matched group 60 examples.
3, treatment group medication: product granule of the present invention, oral, each 10 grams, every day 3 times.
The matched group medication: GUXIAN PIAN, oral, each 6, every day 3 times.
4, the course of treatment: 30 days, and tried the patient during the clinical verification and can not adopt other relevant treatment simultaneously
Curative effect index:
1, observation index: the gonalgia, activity is unfavorable, be afraid of cold in the part, morning deadlock.
2, observe the difficulty of having squatted, upward go downstairs difficulty and difficulty in walking.
3, X-ray examination.
Safety indexes:
1, general health check-up project.
2, blood, routine urinalysis.
Curative effect determinate standard:
1, clinic control: treat the back symptom and disappear substantially.
2, produce effects: treat the back symptom and obviously improve.
3, effective: as to treat the back doing well,improving.
4, invalid: as not reach effective standard.
Result of the test: the every data to clinical trial are carried out statistical procedures, general enumeration data X 2 test, and measurement data is checked with t, and the level data data is analyzed with Ridit.Concrete data see the following form.
Table one total effects analytical table
| The example number | Clinic control | Produce effects | Effectively | Invalid |
| Granule group of the present invention | 110 | 22 | 36 | 40 | 12 |
| The GUXIAN PIAN group | 107 | 16 | 25 | 54 | 12 |
R
Of the present invention group=0.456, R
The GUXIAN PIAN group=0.514 U=1.53 P＞0.05
Above data show that two groups of total effectses are similar, but two groups of above cases of produce effects are compared u=2.13, P＜0.05, and of the present invention group significantly better than the GUXIAN PIAN group.
Table two arthralgia is alleviated table
| The example number | Disappear | Effectively | Invalid | |
| Granule group of the present invention | 110 | 40(43.64％) | 52(47.27％) | 18(16.36％) |
| The GUXIAN PIAN group | 107 | 35(32.71％) | 55(51.40％) | 17(15.89％) |
Above data show that two groups of total effectses are similar, and still the case of two groups of transference cures is compared, and of the present invention group significantly better than the GUXIAN PIAN group.
Claims (7)
1. Chinese medicine composition that is used for the treatment of arthralgia, it is made up of effective ingredient or effective ingredient and pharmaceutically acceptable carrier, it is characterized in that described effective ingredient made by following raw materials according:
Radix Achyranthis Bidentatae 218-307 weight portion Radix Clematidis 218-307 weight portion
Fructus Psoraleae 131-217 weight portion Cortex Eucommiae 131-217 weight portion
Fructus Chaenomelis 131-217 weight portion Rhizoma Chuanxiong 218-307 weight portion
Radix Angelicae Sinensis 131-217 weight portion Radix Paeoniae Alba 131-217 weight portion
Radix Cynanchi Paniculati 131-217 weight portion Ramulus Cinnamomi 131-217 weight portion
Scorpio 21-88 weight portion Scolopendra 21-88 weight portion
Radix Pseudostellariae 131-217 weight portion.
2. according to the Chinese medicine composition described in the claim 1, be characterised in that preparation raw materials of effective components and consumption thereof are:
Radix Achyranthis Bidentatae 240-285 weight portion Radix Clematidis 240-285 weight portion
Fructus Psoraleae 153-197 weight portion Cortex Eucommiae 153-197 weight portion
Fructus Chaenomelis 153-197 weight portion Rhizoma Chuanxiong 240-285 weight portion
Radix Angelicae Sinensis 153-197 weight portion Radix Paeoniae Alba 153-197 weight portion
Radix Cynanchi Paniculati 153-197 weight portion Ramulus Cinnamomi 153-197 weight portion
Scorpio 21-66 weight portion Scolopendra 21-66 weight portion
Radix Pseudostellariae 153-197 weight portion.
3. Chinese medicine composition according to claim 1 wherein prepares raw materials of effective components and consumption thereof and is:
Radix Achyranthis Bidentatae 250 weight portion Radix Clematidis 250 weight portion Fructus Psoraleaes 167 weight portions
The Cortex Eucommiae 167 weight portion Fructus Chaenomeliss 167 weight portion Rhizoma Chuanxiongs 250 weight portions
The Radix Angelicae Sinensis 167 weight portion Radix Paeoniae Albas 167 weight portion Radix Cynanchi Paniculatis 167 weight portions
Ramulus Cinnamomi 167 weight portion Scorpios 50 weight portion Scolopendras 50 weight portions
Radix Pseudostellariae 167 weight portions.
4. Chinese medicine composition according to claim 1, it is granule, capsule, tablet, pill or oral liquid.
5. according to the preparation method of any one described Chinese medicine composition among the claim 1-4, it comprises:
(a) Scorpio and Scolopendra are ground into fine powder, with Fructus Psoraleae and Rhizoma Chuanxiong 60-80 volume % ethanol water heating and refluxing extraction three times, each 1-3 hour, merge extractive liquid, also filtered, and relative density is the clear paste of 1.02-1.05 60 ℃ the time with being concentrated into behind the filtrate recycling ethanol;
(b) Radix Angelicae Sinensis, Ramulus Cinnamomi and Radix Cynanchi Paniculati are extracted volatile oil, the aqueous solution after distillation device is in addition collected, and volatile oil is mixed with Borneolum Syntheticum, carries out inclusion with cyclodextrin and water then, stirs 1-3 hour at 60 ℃, and cold preservation is spent the night, and filters, and is ground into fine powder after the cold drying;
(c) with above-mentioned medicinal residues and Radix Achyranthis Bidentatae, Radix Clematidis, the Cortex Eucommiae, Fructus Chaenomelis, the Radix Paeoniae Alba, Radix Pseudostellariae decocts with water three times together, each 1-3 hour, collecting decoction, filter and with the aqueous solution merging after the distillation in filtrate and the above-mentioned steps (b), be concentrated into that relative density is the clear paste of 1.02-1.05 in the time of 60 ℃, then with 2000-3000 rev/min rotating speed centrifugalize, the clear paste of getting in supernatant and the above-mentioned steps (a) merges, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃, through vacuum drying, resulting dry thing is crushed to fine powder, mix evenly with the fine powder of the middle volatile oil inclusion complex of above-mentioned steps (b) and the fine powder of Scorpio and Scolopendra again, make various dosage forms with pharmaceutically acceptable carrier or excipient then, promptly obtain Chinese medicine composition of the present invention.
6. preparation method according to claim 5 is characterized in that the described concentration of alcohol of step (a) is 70%, make a living by weight 6 times of dose of alcoholic solution consumption.
7. the preparation method of medicine according to claim 5 is characterized in that the rotating speed of the described centrifugalize of step (c) is 2500 rev/mins.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2003101035245A CN1304027C (en) | 2003-11-06 | 2003-11-06 | Bone nourishing and rheumatic treating pills and their preparation |
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| CNB2003101035245A CN1304027C (en) | 2003-11-06 | 2003-11-06 | Bone nourishing and rheumatic treating pills and their preparation |
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| CN1304027C true CN1304027C (en) | 2007-03-14 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1391943A (en) * | 2002-06-10 | 2003-01-22 | 郭好建 | Chinese medicine paste for curing osteoarthropathy and preparing method |
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