CN1281252C - Medicinal composition for treating urinary lithiasis and its preparing method - Google Patents
Medicinal composition for treating urinary lithiasis and its preparing method Download PDFInfo
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- CN1281252C CN1281252C CN 200410071161 CN200410071161A CN1281252C CN 1281252 C CN1281252 C CN 1281252C CN 200410071161 CN200410071161 CN 200410071161 CN 200410071161 A CN200410071161 A CN 200410071161A CN 1281252 C CN1281252 C CN 1281252C
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Abstract
The present invention discloses a medicinal composition for treating urinary calculi and a preparation method thereof. The medicinal composition comprises active ingredients and/or pharmaceutically acceptable additives which are prepared from the following raw materials by a proportion by weight: 3 to 60 shares of clematis root, 3 to 50 shares of japanese climbing fern spore, 3 to 30 shares of water plantain, 3 to 60 shares of milkvetch root, 3 to 15 shares of hemlock parsley, 3 to 60 shares of nutgrass galingale rhizome, 3 to 15 shares of polyporus, 3 to 15 shares of tuckahoe, 3 to 30 shares of yellow croaker ear-stone, 1 to 5 shares of magnesium oxide and 0.02 to 0.1 share of vitamin B6. The product of the present invention has good effect on expelling and dissolving calculi, and can improve functions of the kidney, enhance physique, protect the kidney and reduce occurrence of urinary calculi and the complicating diseases.
Description
Invention field
The present invention relates to a kind of pharmaceutical composition for the treatment of urinary system calculus and preparation method thereof, more particularly treat Chinese medicine composition of urinary system calculus and preparation method thereof about a kind of Chinese medicine that adopts.
Background technology
Urinary system calculus is a global disease, also is one of modal urologic disease of China, and especially China south sickness rate is very high, is one of three popular districts of main urinary system calculus, the world.
Urinary system calculus accounts for the 15-30% of Urology Surgery, and relapse rate is high by about 15%, and there is New Development patient about 1,500 ten thousand in annual China, improves with people's living standard, and sickness rate is also set up trend.Having a strong impact on and producing and life.
The primary disease Drug therapy runs into following problem both at home and abroad at present.
1, the effect of diuretic hydrochlorothiazide is limited, and side effect is big, headache, depression, erythra etc. is arranged, and can cause diabetes and gout.
2, potassium citrate, preventing and treating calculus has certain curative effect, separately the application of treatment weak effect.
3, allopurinol only has certain therapeutical effect, but side effect is many, and serious toxic hepatitis may take place, vasculitis etc. even threat to life.Though the Chinese patent medicine of some treatment urinary system calculus is also arranged, urinary system calculus there is certain curative effect, the course of treatment is long, and cure rate is on the low side about about 30-50%.
Summary of the invention
One of purpose of the present invention provides a kind of good calculus litholytic effect that has, and can improve renal function, improves body constitution, protection kidney, the pharmaceutical composition of the treatment urinary system calculus of minimizing urinary system calculus complication.
Two of purpose of the present invention provides a kind of preparation of drug combination method for the treatment of urinary system calculus.
These and other objects of the present invention will further embody and illustrate by following detailed.
The pharmaceutical composition of treatment urinary system calculus of the present invention comprises the active component and/or the pharmaceutically acceptable additives that are made by following raw materials according:
Radix Clematidis 3-60 weight portion Spora Lygodii 3-50 weight portion
Rhizoma Alismatis 3-30 weight portion Radix Astragali 3-60 weight portion
Rhizoma Chuanxiong 3-15 weight portion Rhizoma Cyperi 3-60 weight portion
Polyporus 3-15 weight portion Poria 3-15 weight portion
Asteriscus Pseudosciaenae 3-30 weight portion magnesium oxide 1-5 weight portion
Vitamin B6 0.02-0.1 weight portion.
Further, the pharmaceutical composition of treatment urinary system calculus of the present invention comprises the active component and/or the pharmaceutically acceptable additives that are made by following raw materials according:
Radix Clematidis 5-30 weight portion Spora Lygodii 3-30 weight portion
Rhizoma Alismatis 3-15 weight portion Radix Astragali 5-30 weight portion
Rhizoma Chuanxiong 3-9 weight portion Rhizoma Cyperi 5-45 weight portion
Polyporus 3-9 weight portion Poria 3-9 weight portion
Asteriscus Pseudosciaenae 5-25 weight portion magnesium oxide 1-5 weight portion
Vitamin B6 0.02-0.06 weight portion.
Be preferably, the pharmaceutical composition of treatment urinary system calculus of the present invention comprises the active component and/or the pharmaceutically acceptable additives that are made by following raw materials according:
Radix Clematidis 18 weight portion Spora Lygodii 18 weight portions
The Rhizoma Alismatis 6 weight portion Radixs Astragali 18 weight portions
Rhizoma Chuanxiong 6 weight portion Rhizoma Cyperis 30 weight portions
Polyporus 8 weight portion Poria 8 weight portions
Asteriscus Pseudosciaenae 15 weight portion magnesium oxide 1 weight portion
Vitamin B6 0.03 weight portion.
The pharmaceutical composition of treatment urinary system calculus of the present invention can be made any pharmaceutically acceptable dosage form, and preferred dosage form is powder or capsule, can certainly be tablet.
The preparation of drug combination method of treatment urinary system calculus of the present invention comprises the steps:
A, preparation Radix Astragali extract:
The Radix Astragali made coarse powder,, obtain filtrate and medicinal residues with 95% reflux, extract, filtration repeatedly (1), earlier;
(2), filtrate reclaims to place behind the solvent and separates out crystallization, crystallization above removing is filtered, the mother solution volatilization is clean, remaining ethanol extraction is standby;
(3), medicinal residues filter with water extraction, filtrate concentrates, and adds 5 times of amount ethanol and stirs, and leaves standstill filtration, precipitate adds 50-70 ℃ of hot water dissolving and filters, filtrate adds the abundant sedimentation and filtration of 95% ethanol, drying precipitate gets total polysaccharides;
(4), merge ethanol extraction and total polysaccharides standby;
B, get Radix Clematidis, Spora Lygodii, Rhizoma Alismatis, Rhizoma Chuanxiong, Polyporus, Poria, Asteriscus Pseudosciaenae and Rhizoma Cyperi and clean, make coarse powder, fully soak through infrared drying, insert then in the decoction container, add water logging and cross powder 10-20 centimetre, heating decocts, decocted each 1-3 hour, 1-3 time altogether, when emitting decoction liquor, filter with gauze or scalping, after emitting decoction liquor for the last time, the squeezing medicinal residues, and merge slag liquid and decoction liquor concentrated, be concentrated into the 10-20% of material quantity in concentrator, extract powder is made in oven dry;
C, with Radix Astragali extract, extract powder and magnesium oxide, vitamin B6 mixed together evenly, be crushed to 120 orders, microwave 5 minutes, sterilization treatment gets pharmaceutical composition.
D, the pharmaceutical composition after the sterilization treatment is made powder, divide the capsule of packing into, about every heavy 0.4 gram.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to urinary system calculus and complication mechanism thereof; with reference to modern pharmacology research achievement; from motherland's medicine treasure-house, filter out kidney-boosting tonic; activating blood circulation to dissipate blood stasis, calculus dissolving and excreting, the strong body of tonify deficiency; suppress the glomerule fibrosis; renal blood flow increasing improves renal function, reduces the natural plant of complication; by theory of Chinese medical science; combination of Chinese and Western medicine prescription skims the cream off milk, scientific matching; promote the dissolving and the discharge of urinary system calculus; the treatment urinary system calculus, the protection kidney reduces complication and takes place.Contain molybdenum, strontium, zinc and a large amount of magnesium in the pharmaceutical composition of treatment urinary system calculus of the present invention, by analysis, molybdenum content is 65.2ppm in every capsules, and content of strontium is 514ppm, and zinc content is 1180ppm, and these four kinds of elements have facilitation to the calculus lithodialysis.
The pharmaceutical composition of treatment urinary system calculus of the present invention has following advantage through clinical use proof:
1, because to select natural drug for use be raw material, so the each component compatibility meets the regulation of Medicine Act, and each medicine comprehensive function treatment urinary calculi of distinguishing the flavor of is nontoxic to human body;
2, therapeutic effect is obvious, and can alleviate hydronephrosis significantly, improves renal function, enhancing human body immunity power.
Below in conjunction with embodiment in detail the present invention is described in detail, can not limits the scope of the invention but embodiment only is used for explanation.
In the present invention, if not refer in particular to, all part, percentage ratios are unit of weight, and all equipment and raw material etc. all can be buied from market or the industry is commonly used.
The specific embodiment
Example 1
A, takes by weighing to mix by following proportioning and use raw material, and step prepares as follows:
3 kilograms of 5 kilograms of Rhizoma Alismatis of 5 kilograms of Spora Lygodii of Radix Clematidis
5 kilograms of 3 kilograms of Rhizoma Cyperis of 5 kilograms of Rhizoma Chuanxiongs of the Radix Astragali
3 kilograms of 3 kilograms of Asteriscus Pseudosciaenaes of 3 kilograms of Poria of Polyporus
0.03 kilogram of 1 kilogram of vitamin B6 of magnesium oxide.
B prepares Radix Astragali extract (method of this step also can be used the extracting method of prior art):
The Radix Astragali made coarse powder,, obtain filtrate and medicinal residues with the reflux, extract, filtration repeatedly of 95% ethanol (1), earlier;
(2), filtrate reclaims to place behind the solvent and separates out crystallization, removes crystallization, filters, the mother solution volatilization is clean, remaining ethanol extraction is standby;
(3), medicinal residues filter with water extraction, filtrate concentrates, and adds 5 times of amount ethanol and stirs, and leaves standstill filtration, precipitate adds 50-70 ℃ of hot water dissolving and filters, filtrate adds the abundant sedimentation and filtration of 95% ethanol, drying precipitate gets total polysaccharides;
(4), merge ethanol extraction and total polysaccharides standby;
C, get Radix Clematidis, Spora Lygodii, Rhizoma Alismatis, Rhizoma Chuanxiong, Polyporus, Poria, Asteriscus Pseudosciaenae and Rhizoma Cyperi and clean, make coarse powder, fully soak through infrared drying, insert then in the decoction container, add water logging and cross powder 10-20 centimetre, heating decocts, decocted each 1.5 hours, totally 2 times, when emitting decoction liquor, filter with gauze or scalping, after emitting decoction liquor for the last time, the squeezing medicinal residues, and merge slag liquid and decoction liquor concentrated, be concentrated into the 10-20% of material quantity in concentrator, extract powder is made in oven dry;
D, with Radix Astragali extract, extract powder and magnesium oxide, vitamin B6 mixed together are even, are crushed to 120 orders, 60 ℃ in microwave 5 minutes, sterilization treatment is made powder, divide encapsulated, every heavy 0.4g.
Example 2
Take by weighing mixing by following proportioning and use raw material, preparation method is with example 1.
26 kilograms of 50 kilograms of Rhizoma Alismatis of 55 kilograms of Spora Lygodii of Radix Clematidis
55 kilograms of 15 kilograms of Rhizoma Cyperis of 55 kilograms of Rhizoma Chuanxiongs of the Radix Astragali
30 kilograms of 15 kilograms of Asteriscus Pseudosciaenaes of 15 kilograms of Poria of Polyporus
0.1 kilogram of 5 kilograms of vitamin B6 of magnesium oxide.
Example 3
Take by weighing mixing by following proportioning and use raw material, preparation method is with example 1.
14 kilograms of 25 kilograms of Rhizoma Alismatis of 30 kilograms of Spora Lygodii of Radix Clematidis
30 kilograms of 7 kilograms of Rhizoma Cyperis of 30 kilograms of Rhizoma Chuanxiongs of the Radix Astragali
15 kilograms in 7 kilograms of fish brains of 8 kilograms of Poria of Polyporus
0.07 kilogram of 2 kilograms of vitamin B6 of magnesium oxide, the starch or other excipient that add convention amount are made tablet.
Example 4
A, takes by weighing to mix by following proportioning and use raw material, and step prepares as follows:
6 kilograms of 9 kilograms of Rhizoma Alismatis of 9 kilograms of Spora Lygodii of Radix Clematidis
10 kilograms of 5 kilograms of Rhizoma Cyperis of 9 kilograms of Rhizoma Chuanxiongs of the Radix Astragali
10 kilograms of 5 kilograms of Asteriscus Pseudosciaenaes of 6 kilograms of Poria of Polyporus
0.02 kilogram of 1 kilogram of vitamin B6 of magnesium oxide;
B, preparation Radix Astragali extract
The Radix Astragali made coarse powder,, obtain filtrate and medicinal residues with the reflux, extract, filtration repeatedly of 95% ethanol (1), earlier;
(2), filtrate reclaims to place behind the solvent and separates out crystallization, removes crystallization, filters, the mother solution volatilization is clean, remaining ethanol extraction is standby;
(3), medicinal residues filter with water extraction, filtrate concentrates, and adds 5 times of amount ethanol and stirs, and leaves standstill filtration, precipitate adds 50-70 ℃ of hot water dissolving and filters, filtrate adds the abundant sedimentation and filtration of 95% ethanol, drying precipitate gets total polysaccharides;
(4), merge ethanol extraction and total polysaccharides standby;
C, get Radix Clematidis, Spora Lygodii, Rhizoma Alismatis, Rhizoma Chuanxiong, Polyporus, Poria, Asteriscus Pseudosciaenae, Rhizoma Cyperi wash clean infrared drying and make coarse powder, fully overflow bubble, insert then and decoct in the container, add water logging and cross 15 centimetres of powder, heating decocts, and decocts each 1.5 hours, totally 2 times, when emitting decoction liquor, filter with gauze or scalping, emit decoction liquor for the last time after, the squeezing medicinal residues, and slag liquid and decoction liquor merging is concentrated, in concentrator, be concentrated into about 1/6 of raw material, extract powder is made in oven dry;
D, with Radix Astragali extract, extract powder and magnesium oxide, the vitamin B6 mixed together is even, is crushed to 120 orders, 60 ℃ in microwave 5 minutes, sterilization treatment is made powder, divide encapsulated, every heavy 0.4g.
Example 5 tests of pesticide effectiveness
For showing the therapeutic effect of medicine of the present invention to urinary system calculus, the present invention is through the clinical observation of 300 routine case systems, and selection medical history, the state of an illness, age, sex and suitable urinary system calculus patient 100 examples of Therapeutic Method, if matched group 1, matched group 2 each 50 example, select case to meet the urinary system calculus diagnostic criteria, all do X line and ultrasound diagnosis and make a definite diagnosis.Chinese medical discrimination is damp and hot silt resistance card.The calculus size is 0.5cm＜transverse diameter≤1.0cm, 0.6＜vertical footpath≤1.8cm, and calculus is stopped in 1 year in certain one, below the hydronephrosis moderate, microlith eliminator voluntarily behind the external stone crushing, routine urianlysis leukocyte＜20 do not have serious other diseases person.
Treatment group medication compound recipe Radix Clematidis capsule, each 6, every day three times, oral.
Matched group 1 is used JIESHITONG PIAN, and is each 6, every day three times, oral.
Matched group 2 is used SHENSHITONG CHONGJI, and each 1 bag is every day three times, oral.
30 days is a course of treatment, the other drug of stopping using during the treatment.
Therapeutic outcome: the treatment group significantly is better than two matched groups, and P＜0.01 sees Table, and lithagogue rate treatment group also is better than two matched groups, and P＜0.01 kidney and ureter calculus chronotherapy group are significantly shorter than matched group P＜0.01.
The treatment group: compound recipe Radix Clematidis capsule,
Matched group 1: JIESHITONG PIAN,
Matched group 2: SHENSHITONG CHONGJI
Table one efficacy analysis
| Example number n | Cure n (%) | Produce effects n (%) | Effective n (%) | Invalid n (%) | Total obvious effective rate (%) | Total effective rate (%) | |
| The treatment group | 300 | 240 80 | 33 11 | 21 7 | 6 2 | 91％ | 98％ |
| Matched group 1 | 50 | 19 38 | 10 20 | 12 24 | 9 18 | 58％ | 82％ |
| Matched group 2 | 50 | 21 42 | 11 22 | 10 20 | 8 16 | 64％ | 84％ |
Table two lithagogue rate relatively
| The example number | Stone number before treating | Treat back stone number | The calculus number | Lithagogue rate | |
| The treatment group | 300 | 300 | 60 | 240 | 80％ |
| Matched group 1 | 50 | 50 | 31 | 19 | 38％ |
| Matched group 2 | 50 | 50 | 29 | 21 | 42％ |
The time relative analysis of table three calculus
| Kidney X ± S days | Ureter X ± S days | |
| The treatment group | 62 11.2±5.9 | 176 6±3.5 |
| Matched group 1 | 6 20.5±6.6 | 13 15±7.5 |
| Matched group 2 | 7 21±7.1 | 14 15±8.8 |
The treatment statistics shows that the capsular medicament of compound recipe Radix Clematidis urinary calculi is obtained significant curative effect to 300 routine urinary system calculus patients do therapeutic test, and cure rate reaches 80%, and total obvious effective rate reaches 91%, and effective percentage reaches 98%, has obtained remarkable result.
Claims (8)
1, a kind of pharmaceutical composition for the treatment of urinary system calculus is characterized in that it is active component and/or the pharmaceutically acceptable additives that made by following raw materials according:
Radix Clematidis 3-60 weight portion Spora Lygodii 3-50 weight portion
Rhizoma Alismatis 3-30 weight portion Radix Astragali 3-60 weight portion
Rhizoma Chuanxiong 3-15 weight portion Rhizoma Cyperi 3-60 weight portion
Polyporus 3-15 weight portion Poria 3-15 weight portion
Asteriscus Pseudosciaenae 3-30 weight portion magnesium oxide 1-5 weight portion
Vitamin B6 0.02-0.1 weight portion.
2, the pharmaceutical composition of treatment urinary system calculus according to claim 1 is characterized in that it is active component and/or the pharmaceutically acceptable additives that made by following raw materials according:
Radix Clematidis 5-30 weight portion Spora Lygodii 3-30 weight portion
Rhizoma Alismatis 3-15 weight portion Radix Astragali 5-30 weight portion
Rhizoma Chuanxiong 3-9 weight portion Rhizoma Cyperi 5-45 weight portion
Polyporus 3-9 weight portion Poria 3-9 weight portion
Asteriscus Pseudosciaenae 5-25 weight portion magnesium oxide 1-5 weight portion
Vitamin B6 0.02-0.06 weight portion.
3, the pharmaceutical composition of treatment urinary system calculus according to claim 1 is characterized in that it is active component and/or the pharmaceutically acceptable additives that made by following raw materials according:
CHENGLINGXIAN 18 weight portion Spora Lygodii 18 weight portions
The Rhizoma Alismatis 6 weight portion Radixs Astragali 18 weight portions
Rhizoma Chuanxiong 6 weight portion Rhizoma Cyperis 30 weight portions
Polyporus 8 weight portion Poria 8 weight portions
Asteriscus Pseudosciaenae 15 weight portion magnesium oxide 1 weight portion
Vitamin B6 0.03 weight portion.
4,, it is characterized in that described pharmaceutical composition can make any pharmaceutically acceptable dosage form according to the pharmaceutical composition of the described treatment urinary system calculus of one of claim 1-3.
5, the pharmaceutical composition of treatment urinary system calculus according to claim 4 is characterized in that described dosage form is powder or capsule.
6, according to the preparation of drug combination method of the described treatment urinary system calculus of one of claim 1-3, it is characterized in that comprising the steps:
A, preparation Radix Astragali extract:
The Radix Astragali made coarse powder,, obtain filtrate and medicinal residues with the reflux, extract, filtration repeatedly of 95% ethanol (1), earlier;
(2), filtrate reclaims to place behind the solvent and separates out crystallization, removes crystallization, filters, the mother solution volatilization is clean, remaining ethanol extraction is standby;
(3), medicinal residues filter with water extraction, filtrate concentrates, and adds 5 times of amount ethanol and stirs, and leaves standstill filtration, precipitate adds 50-70 ℃ of hot water dissolving and filters, filtrate adds the abundant sedimentation and filtration of 95% ethanol, drying precipitate gets total polysaccharides;
(4), merge ethanol extraction and total polysaccharides standby;
B, get Radix Clematidis, Spora Lygodii, Rhizoma Alismatis, Rhizoma Chuanxiong, Polyporus, Poria, Asteriscus Pseudosciaenae and Rhizoma Cyperi and clean, make coarse powder, fully soak through infrared drying, insert then in the decoction container, add water logging and cross powder 10-20 centimetre, heating decocts, decocted each 1-3 hour, 1-3 time altogether, when emitting decoction liquor, filter with gauze or scalping, after emitting decoction liquor for the last time, the squeezing medicinal residues, and merge slag liquid and decoction liquor concentrated, be concentrated into the 10-20% of material quantity in concentrator, extract powder is made in oven dry;
C, with Radix Astragali extract, extract powder and magnesium oxide, vitamin B6 mixed together are even, are crushed to 120 orders, 50-70 ℃ of following microwave 5 minutes, sterilization treatment gets pharmaceutical composition.
7, the preparation of drug combination method of treatment urinary system calculus according to claim 6 is characterized in that the pharmaceutical composition after the sterilization treatment is made powder, divides the capsule of packing into, about every heavy 0.4 gram.
8, the preparation of drug combination method of treatment urinary system calculus according to claim 6 is characterized in that the pharmaceutical composition after the sterilization treatment is added conventional excipient makes tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410071161 CN1281252C (en) | 2004-07-30 | 2004-07-30 | Medicinal composition for treating urinary lithiasis and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410071161 CN1281252C (en) | 2004-07-30 | 2004-07-30 | Medicinal composition for treating urinary lithiasis and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1586603A CN1586603A (en) | 2005-03-02 |
| CN1281252C true CN1281252C (en) | 2006-10-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410071161 Expired - Fee Related CN1281252C (en) | 2004-07-30 | 2004-07-30 | Medicinal composition for treating urinary lithiasis and its preparing method |
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| CN (1) | CN1281252C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686503B (en) * | 2005-04-22 | 2010-11-10 | 复旦大学 | External use medicinal preparation for treating pelvic infection |
| CN103417946B (en) * | 2013-08-20 | 2015-05-20 | 周燕 | Drug for treatment of urinary calculus |
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- 2004-07-30 CN CN 200410071161 patent/CN1281252C/en not_active Expired - Fee Related
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Granted publication date: 20061025 Termination date: 20090730 |