CN1055227C - Medicine for treating masculine sterility - Google Patents
Medicine for treating masculine sterility Download PDFInfo
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- CN1055227C CN1055227C CN96109671A CN96109671A CN1055227C CN 1055227 C CN1055227 C CN 1055227C CN 96109671 A CN96109671 A CN 96109671A CN 96109671 A CN96109671 A CN 96109671A CN 1055227 C CN1055227 C CN 1055227C
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Abstract
The present invention relates to a medicinal composition for treating male sterility, which is prepared from fleece-flower root, solomonseal rhizome, barbary wolfberry fruit, dodder seed, desertliving cistanche, epimedium herb, human placenta, Chinese magnoliavine fruit, himalayan teasel root, common cnidium fruit, prepared rehmannia root, pilose asiabell root, Chinese angelica, mongolian dandelion herb, honeycomb, patrinia, oyster shell, red sage root, leech and plantain seed.
Description
The present invention is a kind of medicine for the treatment of male infertility, be specifically a kind of be the Chinese patent medicine that effective ingredient is prepared from the Chinese herbal medicine, belong to field of pharmaceutical preparations.
In world population, the male accounts for more than 50%, and is the same with the women, and the male also has self distinctive physiology and pathological characteristic, and both sides are bearing the process of becoming pregnant of life jointly.Equally, cause infertile reason can not ignore the factor on the bridegroom's or husband's side.Investigate in 10,000 pairs of infertile couples according to The World Health Organization (WHO), may cause the factor of male sterility to account for 33%, the factor of female sterility accounts for 25%, and both sides' common factor accounts for 20%, and both sides can not find reason and account for 15%.In other words, sterile reason because of the bridegroom's or husband's side accounts for more than 55%.In recent years, bibliographical information is arranged constantly both at home and abroad, the quality of mankind spermatozoon has a declining tendency, and the prevalence of male sterility rises gradually.But, up to the present, also there is not a kind of medicine that can effectively treat male sterility, and Chinese medicine is with the theory and the treatment means of its uniqueness, in the function of adjusting hypothalamic pituitary gonadal axis and endocrine unusual, improve the quality of sperm, regulate aspect treatment male sterilities such as immune function, have special advantage.Therefore, effective pure Chinese medicinal preparation of development treatment male infertility can solve urgent needs clinically, to replenish the deficiency of modern treatment male sterility.
Purpose of the present invention is exactly to provide a kind of medicine that can effectively treat male sterility in order to satisfy above-mentioned clinical demand.
The objective of the invention is to realize according to following theory and technology scheme.
Theory of Chinese medical science thinks, male sterility is caused by liver and kidney deficiency, vital essence deficiency, qi depression to blood stasis, damp and hot strongly fragrant due to the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.The inventor by at all times surplus in the of 50 the medicine in the sterile side's medicine of treatment screen, and in conjunction with the medication experience of long-term treatment male infertility,, developed medicine of the present invention to fill up kidney essense, the blood circulation promoting and blood stasis dispelling principles of formulating prescriptions of clearing away damp-heat of holding concurrently.
According to theory of Chinese medical science, kidney governing reproduction, kidney qi is contained, kidney essense is filled then can son, the prosperous then kidney essense of QI and blood is active, this medicine is reused Radix Polygoni Multiflori, Rhizoma Polygonati, Fructus Lycii and is monarch in view of the above, and being equipped with Semen Cuscutae, Herba Cistanches, Herba Epimedii, Placenta Hominis, Fructus Schisandrae Chinensis, Radix Dipsaci, Fructus Cnidii, Radix Rehmanniae Preparata, Radix Codonopsis, Radix Angelicae Sinensis kidney tonifying, essence replenishing, benefiting QI and nourishing blood is a minister; Modern clinical and relevant studies have shown that, male sterility and " damp and hot ", " stasis of blood ", " poison " are closely related, so with the product of Herba Taraxaci, Herba Patriniae, Semen Plantaginis, Nidus Vespae, Concha Ostreae, Radix Salviae Miltiorrhizae, Hirudo heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, assist for assistant to make, become the kidney invigorating and essence nourishing altogether, the product of heat clearing away repercussive.
Pharmaceutical composition of the present invention is composed as follows by weight ratio:
Radix Polygoni Multiflori 100-300 part
Rhizoma Polygonati 50-150 part
Fructus Lycii 40-120 part
Semen Cuscutae 40-120 part
Herba Cistanches 40-120 part
Herba Epimedii 40-120 part
Placenta Hominis 10-80 part
Fructus Schisandrae Chinensis 10-60 part
Radix Dipsaci 10-50 part
Fructus Cnidii 10-50 part
Radix Rehmanniae Preparata 10-50 part
Radix Codonopsis 10-50 part
Radix Angelicae Sinensis 10-50 part
Herba Taraxaci 10-80 part
Nidus Vespae 10-50 part
Herba Patriniae 10-80 part
Concha Ostreae 100-500 part
Radix Salviae Miltiorrhizae 30-100 part
Hirudo 3-30 part
Semen Plantaginis 3-30 part
The preferred weight proportioning of pharmaceutical composition of the present invention is:
Radix Polygoni Multiflori 150-250 part
Rhizoma Polygonati 70-100 part
Fructus Lycii 60-90 part
Semen Cuscutae 60-90 part
Herba Cistanches 60-90 part
Herba Epimedii 60-90 part
Placenta Hominis 30-60 part
Fructus Schisandrae Chinensis 20-40 part
Radix Dipsaci 20-40 part
Fructus Cnidii 20-40 part
Radix Rehmanniae Preparata 20-40 part
Radix Codonopsis 20-40 part
Radix Angelicae Sinensis 20-40 part
Herba Taraxaci 30-70 part
Nidus Vespae 20-40 part
Herba Patriniae 30-70 part
Concha Ostreae 150-300 part
Radix Salviae Miltiorrhizae 40-70 part
Hirudo 5-20 part
Semen Plantaginis 5-20 part
The preferred Radix Polygoni Multiflori Preparata of Radix Polygoni Multiflori in the said components; The preferred processed with wine Rhizoma Polygonati of Rhizoma Polygonati; The preferred parch Nidus Vespae of Nidus Vespae; Semen Plantaginis is preferably used the salt parch.
Aforementioned pharmaceutical compositions of the present invention can be prepared into any pharmaceutical dosage form, comprises tablet, pill, capsule, sublimed preparation, unguentum, oral liquid, medicated wine, medicinal tea, injection etc.Can also contain conventional pharmaceutical excipient in the said pharmaceutical preparation, for example, disintegrating agent, binding agent, thickening agent, emulsifying agent etc.
In the above-mentioned pharmaceutical preparation process of preparation,, above-mentioned pharmaceutical composition can be pulverized simply, mixed or pass through and extract, make preparation according to the needs of different dosage form.
The preparation method of medicine capsule of the present invention is as follows:
1, the process of preparing Chinese medicine of crude drug and pretreatment
Prescription 20 flavor crude drugs, except that Nidus Vespae, Herba Patriniae two flavors, all concoct by the concocting method under the relevant kind item of Chinese Pharmacopoeia (nineteen ninety version), though being Chinese Pharmacopoeia (nineteen ninety version), Nidus Vespae records, its stir-fry Nidus Vespae method is then undertaken by pertinent regulations under this kind item of Jiangsu Province's prepared slices of Chinese crude drugs concocted specification (1992), and Herba Patriniae is then concocted by the concocting method under this kind item of Chinese Pharmacopoeia (version in 1977).
Placenta Hominis is the animal medicinal material that is rich in nutrient substance, and it is serious often to carry disease germs, need through pretreatment, with complete Placenta Hominis with ethanol stifling half an hour, oven drying at low temperature (being no more than 80 ℃) again, the equal effect of going out is comparatively desirable, the finished product that makes meets the regulation of sanitary standard.
2, extract
(1), percolation: Radix Polygoni Multiflori Preparata (2/3rds amounts of recipe quantity), Fructus Schisandrae Chinensis, Fructus Cnidii, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Hirudo powder are broken into coarser powder according to percolation, make solvent with 60% ethanol (quite 10 times of amounts of crude drug), flooded 12 hours, with the speed of per minute 1-3 milliliter percolation slowly, to filtering liquid stream to the greatest extent, stop percolation, collect percolate, filter liquid and be concentrated into thick paste shape (relative density is 1.34-1.40) of reclaim under reduced pressure.
(2), decocting in water: Concha Ostreae is smashed (cloth bag) and add water and be decocted first 0.5 hour, add Rhizoma Polygonati, Fructus Lycii, Semen Cuscutae (cloth bag), Radix Codonopsis, Herba Patriniae, Semen Plantaginis (cloth bag) again and add 8,6, the 5 times amounts of water when crude drug, decoct respectively three times, each 1.5 hours, 1 hour, 1 hour, filter respectively, merging filtrate is concentrated into thick paste shape (relative density is 1.34-1.40).
(3), decocting in water precipitate with ethanol: Herba Cistanches, Herba Epimedii, Radix Dipsaci, Herba Taraxaci, Radix Rehmanniae Preparata, Nidus Vespae are added 10,8,6 times of amounts of water when crude drug, decoct 3 times, be respectively 1,1,0.5 hour, filter respectively, merging filtrate is concentrated into 1: 1 (1 gram crude drug suitable 1 milliliter), adds ethanol and makes and contain the alcohol amount and reach 60%, stir, place more than 10 hours, filter, merge supernatant, decompression recycling ethanol is concentrated into thick paste shape (relative density is 1.34-1.40).
(4), drying: merge 1,2,3 thick pastes, in below 80 ℃, vacuum drying gets the loose dried cream of dark brown brown, and yield is not less than 15%.
3, pulverize: Radix Polygoni Multiflori Preparata (1/3 amount of recipe quantity), Placenta Hominis in below 70 ℃ dry 3 hours, were pulverized 60 mesh sieves, and flour extraction is not less than 85%.
4, mixing, granulation, encapsulated:
The dried cream that step 2 (4) is made mixes with the medicated powder that step 3 makes, and pulverizes, and crosses 80 mesh sieves, granulates in right amount with 95% ethanol, crosses 24 mesh sieves, and is dry below 70 ℃, and granulate is encapsulated.
The experiment proved that: medicine of the present invention can make the attached property of immaturity mice organ pipe prostate, Seminal vesicle, levator ani rise appreciably, and points out this medicine can promote male body reproductive function maturation, and spermatogenesis and sophisticated effect.
Medicine of the present invention can make gossypol load rat sperm count and motility of sperm raise, and points out medicine of the present invention that antagonism gossypol, the epithelial effect of protection testicular spermatogenic are arranged, and helps and educates effect.
Medicine of the present invention has certain blood viscosity lowering, reduces platelet aggregation, and the effect of reduction Fibrinogen generative capacity, thereby quickening blood flow rate improve blood circulation and the reproductive system blood supply is bad, and function of promoting blood circulation to disperse blood clots is arranged.
Medicine of the present invention can make young rat chest gland atrophy, reduces the content of vitamin c in the rat adrenal gland, and the effect of corticotropin sample is arranged, and medicine of the present invention also has resisting fatigue and hypoxia-bearing capability, but takes health invigorating for a long time.
Confirm that by treatment Rhesus Macacus testicular spermatogenic function barrier study can make modeling monkey spermatogenic cell propagation active, the spermatid number obviously increases, the sperm deformity number reduces, and density increases, and vigor improves; Can improve the confession of testis blood, promote the secretion of androgen testosterone, promote prostate and seminal vesicle secretory function to increase.
The clinical observation result of study of Drug therapy male infertility of the present invention shows: take Drug therapy male infertility of the present invention with 2-3 the course of treatment (3 months is a course of treatment) person's effect best, total effective rate is respectively 89.86% and 89.87%.Medicine of the present invention has tangible change effect unusually to five indices such as cell number, rate of teratosperm in sperm concentration, motility rate, energy, the seminal fluid; Can significantly improve the seminal fluid abnormal liquefaction; Obviously improve the average mobility speed of sperm; Can increase the zinc content in oligospermia, the azoospermia patient refining; Serum follicle stimulating hormone (FSH) and interstitialcellstimulating hormone (ICSH) (LH) to oligospermia, azoospermia patients serum have certain regulating action; The Electronic Speculum Ultrastructural observation is the result show.Medicine of the present invention can obviously improve human sperm's quality, can change pathology sperm membrane structure, makes the pathological state of spermatogenesis process change normality into.
Embodiment prepares the capsule of medicine of the present invention
Prescription:
200 parts of Radix Polygoni Multiflori
80 parts of Rhizoma Polygonatis
70 parts of Fructus Lycii
70 parts of Semen Cuscutae
70 parts of Herba Cistanches
70 parts of Herba Epimedii
40 parts of Placenta Hominiss
35 parts of Fructus Schisandrae Chinensis
30 parts of Radix Dipsacis
30 parts of Fructus Cnidiis
30 parts of Radix Rehmanniae Preparata
30 parts of Radix Codonopsis
30 parts of Radix Angelicae Sinensis
50 parts of Herba Taraxacis
30 parts in Nidus Vespae
50 parts of Herba Patriniae
200 parts of Concha Ostreaes
50 parts of Radix Salviae Miltiorrhizaes
10 parts of Hirudos
10 parts of Semen Plantaginiss
Method for making:
1), the process of preparing Chinese medicine of crude drug and pretreatment
Prescription 20 flavor crude drugs, except that Nidus Vespae, Herba Patriniae two flavors, all concoct by the concocting method under the relevant kind item of Chinese Pharmacopoeia (nineteen ninety version), Nidus Vespae is with recording for Chinese Pharmacopoeia (nineteen ninety version), its stir-fry Nidus Vespae method is then undertaken by pertinent regulations under this kind item of Jiangsu Province's prepared slices of Chinese crude drugs concocted specification (1992), and Herba Patriniae is then concocted by the concocting method under this kind item of Chinese Pharmacopoeia (version in 1977).
Placenta Hominis is the animal medicinal material that is rich in nutrient substance, and it is serious often to carry disease germs, need through pretreatment, with complete Placenta Hominis with ethanol stifling half an hour, oven drying at low temperature (being no more than 80 ℃) again, the equal effect of going out is comparatively desirable, the finished product that makes meets the regulation of sanitary standard.
2), extract
(1), percolation: Radix Polygoni Multiflori Preparata (2/3rds amounts of recipe quantity), Fructus Schisandrae Chinensis, Fructus Cnidii, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Hirudo are shone percolation, make solvent with 60% ethanol (quite 10 times of amounts of crude drug), flooded 12 hours, with the speed of per minute 1-3 milliliter percolation slowly, to filtering liquid stream to the greatest extent, stop percolation, collect percolate, filter liquid and be concentrated into thick paste shape (relative density is 1.34-1.40) of reclaim under reduced pressure.
(2), decocting in water: Concha Ostreae is smashed (cloth bag) and add water and be decocted first 0.5 hour, add Rhizoma Polygonati, Fructus Lycii, Semen Cuscutae (cloth bag), Radix Codonopsis, Herba Patriniae, Semen Plantaginis (cloth bag) again and add 8,6, the 5 times amounts of water when crude drug, decoct respectively three times, each 1.5 hours, 1 hour, 1 hour, filter respectively, merging filtrate is concentrated into thick paste shape (relative density is 1.34-1.40).
(3), decocting in water precipitate with ethanol: Herba Cistanches, Herba Epimedii, Radix Dipsaci, Herba Taraxaci, Radix Rehmanniae Preparata, Nidus Vespae are added 10,8,6 times of amounts of water when crude drug, decoct 3 times, be respectively 1,1,0.5 hour, filter respectively, merging filtrate is concentrated into 1: 1 (1 gram crude drug suitable 1 milliliter), adds ethanol and makes and contain the alcohol amount and reach 60%, stir, place more than 10 hours, filter, merge supernatant, decompression recycling ethanol is concentrated into thick paste shape (relative density is 1.34-1.40).
(4), drying: merge 1,2,3 thick pastes, in below 80 ℃, vacuum drying gets the loose dried cream of dark brown brown, and yield is not less than 15%.
3), pulverize: Radix Polygoni Multiflori Preparata (1/3 amount of recipe quantity), Placenta Hominis in below 70 ℃ dry 3 hours, were pulverized 60 mesh sieves, and flour extraction is not less than 85%.
4), mixing, granulation, encapsulated:
With step 2)-dried cream that (4) make mixes with the medicated powder that step 3) makes, and pulverizes, and crosses 80 mesh sieves, granulates in right amount with 95% ethanol, crosses 24 mesh sieves, drying below 70 ℃, and granulate, encapsulated, make 1000 capsules.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of infertility is characterized in that it comprises:
Radix Polygoni Multiflori 100-300 weight portion
Rhizoma Polygonati 50-150 weight portion
Fructus Lycii 40-120 weight portion
Semen Cuscutae 40-120 weight portion
Herba Cistanches 40-120 weight portion
Herba Epimedii 40-120 weight portion
Placenta Hominis 10-80 weight portion
Fructus Schisandrae Chinensis 10-60 weight portion
Radix Dipsaci 10-50 weight portion
Fructus Cnidii 10-50 weight portion
Radix Rehmanniae Preparata 10-50 weight portion
Radix Codonopsis 10-50 weight portion
Radix Angelicae Sinensis 10-50 weight portion
Herba Taraxaci 10-80 weight portion
Nidus Vespae 10-50 weight portion
Herba Patriniae 10-80 weight portion
Concha Ostreae 100-500 weight portion
Radix Salviae Miltiorrhizae 30-100 weight portion
Hirudo 3-30 weight portion
Semen Plantaginis 3-30 weight portion
2,, it is characterized in that it comprises according to the pharmaceutical composition of claim 1:
Radix Polygoni Multiflori 150-250 weight portion
Rhizoma Polygonati 70-100 weight portion
Fructus Lycii 60-90 weight portion
Semen Cuscutae 60-90 weight portion
Herba Cistanches 60-90 weight portion
Herba Epimedii 60-90 weight portion
Placenta Hominis 30-60 weight portion
Fructus Schisandrae Chinensis 20-40 weight portion
Radix Dipsaci 20-40 weight portion
Fructus Cnidii 20-40 weight portion
Radix Rehmanniae Preparata 20-40 weight portion
Radix Codonopsis 20-40 weight portion
Radix Angelicae Sinensis 20-40 weight portion
Herba Taraxaci 30-70 weight portion
Nidus Vespae 20-40 weight portion
Herba Patriniae 30-70 weight portion
Concha Ostreae 150-300 weight portion
Radix Salviae Miltiorrhizae 40-70 weight portion
Hirudo 5-20 weight portion
Semen Plantaginis 5-20 weight portion
3,, it is characterized in that it comprises according to the pharmaceutical composition of claim 2:
Radix Polygoni Multiflori 200 weight portions
Rhizoma Polygonati 80 weight portions
Fructus Lycii 70 weight portions
Semen Cuscutae 70 weight portions
Herba Cistanches 70 weight portions
Herba Epimedii 70 weight portions
Placenta Hominis 40 weight portions
Fructus Schisandrae Chinensis 35 weight portions
Radix Dipsaci 30 weight portions
Fructus Cnidii 30 weight portions
Radix Rehmanniae Preparata 30 weight portions
Radix Codonopsis 30 weight portions
Radix Angelicae Sinensis 30 weight portions
Herba Taraxaci 50 weight portions
Nidus Vespae 30 weight portions
Herba Patriniae 50 weight portions
Concha Ostreae 200 weight portions
Radix Salviae Miltiorrhizae 50 weight portions
Hirudo 10 weight portions
Semen Plantaginis 10 weight portions
4,, it is characterized in that Radix Polygoni Multiflori is a Radix Polygoni Multiflori Preparata in the described component according to the pharmaceutical composition of claim 1 or 2 or 3.
5,, it is characterized in that Rhizoma Polygonati is the processed with wine Rhizoma Polygonati in the described component according to the pharmaceutical composition of claim 1 or 2 or 3.
6,, it is characterized in that Nidus Vespae is the parch Nidus Vespae in the described component according to the pharmaceutical composition of claim 1 or 2 or 3.
7,, it is characterized in that Semen Plantaginis is the Semen Plantaginis with the salt parch in the described component according to the pharmaceutical composition of claim 1 or 2 or 3.
8,, it is characterized in that it is a capsule according to the pharmaceutical composition of claim 1.
9, the method for preparing the described capsule of claim 8 is characterized in that it comprises the steps:
1) extract:
(a) percolation: the Radix Polygoni Multiflori of 2/3rds recipe quantities and Fructus Schisandrae Chinensis, Fructus Cnidii, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, the Hirudo powder of recipe quantity are broken into coarser powder, according to percolation, 60% ethanol with 10 times of amounts of suitable crude drug is made solvent, flooded 12 hours, with the speed of per minute 1-3 milliliter percolation slowly, collect percolate, filter liquid and be concentrated into the thick paste shape that relative density is 1.34-1.40 of reclaim under reduced pressure;
(b) decocting in water: Concha Ostreae smashed add water and be decocted first 0.5 hour, add Rhizoma Polygonati, Fructus Lycii, Semen Cuscutae, Radix Codonopsis, Herba Patriniae, Semen Plantaginis again, and add the water of 8,6,5 times of amounts of suitable crude drug, decoct respectively three times, time was respectively 1.5 hours, 1 hour, 1 hour, filter respectively, merge the liquid of filtering, being concentrated into relative density is the thick paste shape of 1.34-1.40;
(c) decocting in water precipitate with ethanol: Herba Cistanches, Herba Epimedii, Radix Dipsaci, Herba Taraxaci, Radix Rehmanniae Preparata, Nidus Vespae are added the water of 10,8,6 times of amounts of suitable crude drug respectively, decoct 3 times, the time was respectively 1,1,0.5 hour, filter respectively, merging filtrate is concentrated into 1: 1, adds ethanol and makes and contain alcohol amount and reach 60%, stir, place more than 10 hours, filter, merge supernatant, decompression recycling ethanol, being concentrated into relative density is the thick paste shape of 1.34-1.40;
(d) drying: merge a, b, the thick paste of c, in below 80 ℃, vacuum drying gets the loose dried cream of dark brown brown;
2), pulverize: in below 70 ℃ dry 3 hours, it was standby to pulverize 60 mesh sieves with the Placenta Hominis of the Radix Polygoni Multiflori of 1/3 recipe quantity and recipe quantity;
3) mixing, granulation, encapsulated:
Dried cream and step 2 that step 1) is made) medicated powder that makes mixes, and pulverizes, and crosses 80 mesh sieves, granulates in right amount with 95% ethanol, crosses 24 mesh sieves, drying below 70 ℃, granulate, encapsulated.
10,, when it is characterized in that Rhizoma Polygonati, Fructus Lycii, Semen Cuscutae, Radix Codonopsis, Herba Patriniae, Semen Plantaginis and the Concha Ostreae of smashing decocted, decoct a drug wrapped with cloth respectively and boil according to the method for the described capsule of claim 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96109671A CN1055227C (en) | 1996-09-16 | 1996-09-16 | Medicine for treating masculine sterility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96109671A CN1055227C (en) | 1996-09-16 | 1996-09-16 | Medicine for treating masculine sterility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1176794A CN1176794A (en) | 1998-03-25 |
| CN1055227C true CN1055227C (en) | 2000-08-09 |
Family
ID=5120505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96109671A Expired - Lifetime CN1055227C (en) | 1996-09-16 | 1996-09-16 | Medicine for treating masculine sterility |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1055227C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400069C (en) * | 2005-12-13 | 2008-07-09 | 王忠民 | Medicine for improving and protecting male genitality and its preparation method |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344305C (en) * | 2002-05-23 | 2007-10-24 | 李敬纯 | Pure traditional Chinese medicine prepn. for treating male sterility, and its prepn. method |
| CN100434106C (en) * | 2004-04-30 | 2008-11-19 | 上海市闵行区中心医院 | Chinese medicinal composition for treating climacteric syndrome and application thereof |
| CN102441111B (en) * | 2011-12-16 | 2013-05-15 | 淮安市楚州医院 | Chinese patent medicine used for treating infertility, and preparation method thereof |
| CN103202942A (en) * | 2013-04-27 | 2013-07-17 | 上海浦东高星生物技术研究所 | Spermatogenic capsule |
| CN103251893B (en) * | 2013-05-31 | 2014-06-18 | 孙彰 | Traditional Chinese medicine composition for treating male sterility |
| CN106166298A (en) * | 2015-05-21 | 2016-11-30 | 张键 | Use citric acid as the correctives of Aspirin chewable tablets and stabilizer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088809A (en) * | 1993-01-01 | 1994-07-06 | 广州市医药工业研究所 | The compound Chinese patent medicine of treatment male sterility |
-
1996
- 1996-09-16 CN CN96109671A patent/CN1055227C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088809A (en) * | 1993-01-01 | 1994-07-06 | 广州市医药工业研究所 | The compound Chinese patent medicine of treatment male sterility |
Non-Patent Citations (1)
| Title |
|---|
| 湖南医药杂志1983,10(1) 1983.1.1 刘明汉，益精灵治疗男性不育症48例总结 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400069C (en) * | 2005-12-13 | 2008-07-09 | 王忠民 | Medicine for improving and protecting male genitality and its preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1176794A (en) | 1998-03-25 |
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