CN100400069C - Medicine for improving and protecting male genitality and its preparation method - Google Patents
Medicine for improving and protecting male genitality and its preparation method Download PDFInfo
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- CN100400069C CN100400069C CNB200510123117XA CN200510123117A CN100400069C CN 100400069 C CN100400069 C CN 100400069C CN B200510123117X A CNB200510123117X A CN B200510123117XA CN 200510123117 A CN200510123117 A CN 200510123117A CN 100400069 C CN100400069 C CN 100400069C
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Abstract
The present invention discloses a medicine for promoting and protecting male reproductive capacity, which is characterized in that the medicine is prepared from 16 to 48 parts of red sage root, 18 to 24 parts of prepared fleeceflower root, 8 to 24 parts of desertliving cistanche, 10 to 24 parts of curculigo rhizome, 12 to 36 parts of epimedium herb, 16 to 48 parts of barbary wolfberry fruit, 10 to 24 parts of acanthopanax bark, 16 to 48 parts of dodder and 4 to 16 parts of aweto by weight. The medicine has the advantages of convenient use, quick effect taking, high clinic cure rate and no side effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of male sterility, particularly relate to the medicine that a kind of treatment male reproductive function that with the botanical herbs is raw material is made descends.
Background technology
Male reproductive function descends or male sterility is one of common clinical, mainly shows as the sperm quantity deficiency, and motility of sperm and motility rate are low.Have a strong impact on human procreation ability and prenatal and postnatal care, this phenomenon has caused the great attention of the national health organization of connection.China's traditional treatment male reproductive function descends, and how oral based on the herbal decoction piece decoction, this method is used inconvenience, and mouthfeel is poor, and the active ingredient that decocts out is abundant inadequately, and therapeutic effect is undesirable.At present, though the Chinese medicinal capsule of existing spermatogenesis occurs, these medicines have certain therapeutical effect to sperm quantity, quality, but spermatogenesis class Chinese patent medicine prescription in the past is numerous and diverse, specific aim is poor, and effect is not ideal enough, more than the SHENGJING JIAONANG prescription drug 19 that has is distinguished the flavor of, it is outstanding inadequately to cure mainly medicine, and wherein the part medicine does not have the pharmacological action of spermatogenesis.The Chinese patent medicine that some are traditional, as " WUZIYANZONG WAN " etc., curative effect is relatively poor, more is difficult at present male because of multiple pollution such as environment, food, radiation, medicine with rhythm of life is too fast, psychentonia, the treatment that the overweight male reproductive function that waits undesirable element to cause of pressure descends.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that promotes and protect male reproductive function.With traditional dialectical be criterion, the method negative and positive of the kidney invigorating are taken into account, the act of replenishing essence is made a distinction between the important and the lesser one, assistant increases the Chinese medicine Cordyceps that has at promoting testicular function to unclog and readjust in 8 kinds of Chinese herbal medicine among the nourishing, also meets the modern principles of formulating prescriptions of treatment according to differentiation of diseases simultaneously.
The present invention realizes with following technical scheme: a kind of medicine that promotes to protect male reproductive function is characterized in that it is to make with conventional preparation method with following raw medicaments in portion by weight: Radix Salviae Miltiorrhizae 16-48 part, Radix Polygoni Multiflori Preparata 8-24 part, Herba Cistanches 8-24 part, Rhizoma Curculiginis 10-24 part, Herba Epimedii 12-36 part, Fructus Lycii 16-48 part, Cortex Acanthopancis 10-24 part, Semen Cuscutae 16-48 part, Cordyceps 4-16 part.
Above-mentioned raw materials medicine and consumption are that the inventor just draws through repeated tests, all have significant curative effect in above-mentioned amount ranges.
Radix Salviae Miltiorrhizae has the effect of blood circulation promoting and blood stasis dispelling, blood circulation promoting in the side, can increase the blood flow of testis, and testicular function is had the raising effect; Radix Polygoni Multiflori Preparata invigorating the liver and kidney, benefiting essence-blood, animal experiment confirms adrenal gland, the thyroid function effect of being improved to Aged Mice, and good anti-senescence function is arranged; Herba Cistanches the kidney warming benefit is smart, braces up energy and delay senility, and can improve sexual behaviour frequency and sexualities such as copulation and ejaculation to male mice; Herba Epimedii the kidney warming benefit is smart, and QI invigorating is kept fit, and the prostate of animal, seminal vesicle weight are increased, and similar androgenic effect is arranged, and can increase gonepoiesis, and is useful to improving motility of sperm and quantity; Rhizoma Curculiginis temperature compensation Liver and kidney and bone and muscle strengthening, animal experiment has androgen-like action; Fructus Lycii nourishing kidney QI invigorating, tonifying liver is kept fit, and slow down aging improves fertility; The Semen Cuscutae nourishing the liver and kidney, the spermatogenesis of promotion animal is useful to the quality and quantity that improves sperm; Cortex Acanthopancis temperature compensation Liver and kidney, the animal experiment proof can promote male gonad development, has good androgen sample effect; The smart QI invigorating of Cordyceps benefit, life lengthening can make rabbit testicular weight and testicular weight index obviously improve, and has good spermatogenesis and anti-sperm distortion effect.This side combination, negative and positive are all mended, and temperature and not dry is grown and oiliness, male reproductive function is had very significantly promote and protective effect.
Medical material in the said medicine can be adopted the conventional method of Chinese medicine preparation, add adjuvant and can make various oral formulations,, all not influence its therapeutic effect as granule, tablet, pill, capsule, electuary, oral liquid.
The present invention preferably adopts following capsule formulation and tablet.
The preparation method of described medicine, carry out as follows:
(1) weighting raw materials in proportion, standby;
(2) getting Semen Cuscutae adds water and decocts to blow to Semen Cuscutae with pressure cooker and be advisable
(3) Semen Cuscutae that step (2) is blown decocts with water 5 times together with Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Herba Cistanches, Herba Epimedii, Fructus Lycii, Rhizoma Curculiginis and the Cortex Acanthopancis 7 flavor medicines of decocting liquid and described weight ratio, merges 5 times decocting liquid;
(4) get Cordyceps and decoct with water 5 times, merge 5 times decocting liquid;
(5) step (3), (4) gained decocting liquid are condensed into extractum after merging;
(6) extractum is dried dry extract;
(7) pulverize the dry extract powdering;
(8) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(9) incapsulate.
Each amount of water of described step (3) and step (4) was not advisable to have powder, decocted 30 minutes at every turn.
Described step (7) gained medicated powder and tablet adjuvant commonly used is mixed, and tabletting becomes tablet.
Medicine of the present invention shows that through clinical use result following advantage is arranged:
1, to select the natural edible-plant medicine for use be crude drug in the present invention, and each component meets Medicine Act regulation and tcm prescription principle, gives prominence to the dialectical characteristic that combines with differential diagnosis of diseases.
2, medicine of the present invention need not decoct, good mouthfeel, and taking convenience, medicine is nontoxic, and normal dose is taken and is not found any side effect, and onset is rapid.
3, medicine of the present invention descends to male reproductive function not only excellent curative, and the good preventing protective effect is also arranged, and is applicable to the reproductive performance protection adverse circumstances work male.
4, medicine of the present invention has good effect to male sexual disorder.
5, medicament composing prescription flavour of a drug of the present invention are few relatively, avoided square big medicine to have more existing combination untoward reaction, and emphasis is more outstanding.
The specific embodiment
Add up the effect that further specifies medicine of the present invention below in conjunction with embodiment and clinical practice.
Embodiment 1: the capsule preparation
Radix Salviae Miltiorrhizae 24kg, Radix Polygoni Multiflori Preparata 15kg, Herba Cistanches 15kg, Herba Epimedii 20kg, Rhizoma Curculiginis 15kg, Fructus Lycii 24kg, Cortex Acanthopancis 15kg are added the common decoction of entry 5 times, add water at every turn and be not advisable, decocted 30 minutes at every turn, merge 5 times decocting liquid to have powder; Semen Cuscutae 24kg is put into pressure cooker decocts to Semen Cuscutae and blow mouth, in the lump with the said herbal medicine decoction pieces with frying in shallow oil; Do not have the decocting of powder to boil 5 times Cordyceps 10kg adding, each 30 minutes, merged 5 times decocting liquid; Then two kinds of decocting liquids are condensed into extractum; Be dried into dry extract then, again dry extract be broken into fine powder and incapsulate, every medicated powder 0.45g.
Embodiment 2: preparation tablets
With Radix Salviae Miltiorrhizae 10kg, Radix Polygoni Multiflori Preparata 20kg, Herba Cistanches 20kg, Herba Epimedii 25kg, Rhizoma Curculiginis 10kg, Fructus Lycii 40kg, Cortex Acanthopancis 20kg, Cordyceps 8kg, Semen Cuscutae 40kg, make medicated powder with embodiment 1 described method, be aided with tablet adjuvant commonly used again and make tablet.
This clinical drug is observed
One, ordinary circumstance and test method
For confirming the clinical efficacy of medicine of the present invention, year July in January, 2005-2005, select sperm quantity to be lower than 2,000 ten thousand/ml, sperm motility rate＜30%, motility of sperm A level＜10% or A level+B level＜25%, get rid of varicocele, male infertility 162 examples of congenital diseases are divided into medication therapy groups of the present invention (hereinafter to be referred as the treatment group) and matched group at random, and the former establishes matched group 1 example at per 2 examples, treatment group 108 row, matched group 54 examples.The treatment group is taken embodiment 1 medicament capsule, and every day 3 times, each 4, the matched group routine dose is taken LIUWEI DIHUANG WAN, WUZIYANZONG WAN.3 months is a course of treatment, carries out the seminal fluid routine examination 2 times in 1 month after the drug withdrawal, gets meansigma methods 2 times.
Two, clinical observation standard is: above-mentioned three indexs through treating its wife's pregnancy or seminal fluid routine all reach normal person for curing; Sperm quantity＞4,000 ten thousand/ml, sperm motility rate＞50%, motility of sperm A level sperm＞20% or A level+B level＞40% is a produce effects; Sperm quantity, sperm motility rate, motility of sperm all rise to effectively than raising or one of them index before the treatment; Treatment back These parameters does not have raising or the descender is invalid.
Three, observed result shows, the treatment group is cured 60 examples, produce effects 32 examples, and effective 12 examples, invalid 4 examples, total effective rate is 96.29%; Matched group is cured 5 examples, produce effects 13 examples, and effective 22 examples, invalid 14 examples, total effective rate is 74.07%.Learn by statistics and handle, both obvious effective rates have significant difference, P＜0.01.
Claims (4)
1. one kind promotes and the medicine of protection male reproductive function, it is characterized in that it is to make with conventional preparation method extraction with following raw medicaments in portion by weight:
Radix Salviae Miltiorrhizae 16-48 part Radix Polygoni Multiflori Preparata 8-24 part Herba Cistanches 8-24 part
Rhizoma Curculiginis 10-24 part Herba Epimedii 12-36 part Fructus Lycii 16-48 part
Cortex Acanthopancis 10-24 part Semen Cuscutae 16-48 part Cordyceps 4-16 part.
2. method for preparing the described medicine of claim 1 is characterized in that carrying out as follows:
(1) weighting raw materials in proportion, standby;
(2) getting Semen Cuscutae adds water and decocts to blow to Semen Cuscutae with pressure cooker and be advisable;
(3) Semen Cuscutae that step (2) is blown decocts with water 5 times together with Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Herba Cistanches, Herba Epimedii, Fructus Lycii, Rhizoma Curculiginis and the Cortex Acanthopancis 7 flavor medicines of decocting liquid and described weight ratio, merges 5 times decocting liquid;
(4) get Cordyceps and decoct with water 5 times, merge 5 times decocting liquid;
(5) step (3), (4) gained decocting liquid are condensed into extractum after merging;
(6) extractum is dried dry extract;
(7) pulverize the dry extract powdering;
(8) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(9) incapsulate.
3. the method for preparing medicine according to claim 2 is characterized in that each amount of water of step (3) and step (4) was not advisable to have powder, decocts 30 minutes at every turn.
4. preparation method according to claim 2 is characterized in that step (7) gained medicated powder and tablet adjuvant commonly used is mixed, and tabletting becomes tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510123117XA CN100400069C (en) | 2005-12-13 | 2005-12-13 | Medicine for improving and protecting male genitality and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510123117XA CN100400069C (en) | 2005-12-13 | 2005-12-13 | Medicine for improving and protecting male genitality and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1824087A CN1824087A (en) | 2006-08-30 |
| CN100400069C true CN100400069C (en) | 2008-07-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB200510123117XA Expired - Fee Related CN100400069C (en) | 2005-12-13 | 2005-12-13 | Medicine for improving and protecting male genitality and its preparation method |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055227C (en) * | 1996-09-16 | 2000-08-09 | 王�琦 | Medicine for treating masculine sterility |
| CN1094372C (en) * | 1997-06-05 | 2002-11-20 | 廖开福 | Liquor for strengthening Yang |
-
2005
- 2005-12-13 CN CNB200510123117XA patent/CN100400069C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055227C (en) * | 1996-09-16 | 2000-08-09 | 王�琦 | Medicine for treating masculine sterility |
| CN1094372C (en) * | 1997-06-05 | 2002-11-20 | 廖开福 | Liquor for strengthening Yang |
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| Publication number | Publication date |
|---|---|
| CN1824087A (en) | 2006-08-30 |
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Granted publication date: 20080709 Termination date: 20121213 |