CN100400069C - Medicine for improving and protecting male genitality and its preparation method - Google Patents
Medicine for improving and protecting male genitality and its preparation method Download PDFInfo
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- CN100400069C CN100400069C CNB200510123117XA CN200510123117A CN100400069C CN 100400069 C CN100400069 C CN 100400069C CN B200510123117X A CNB200510123117X A CN B200510123117XA CN 200510123117 A CN200510123117 A CN 200510123117A CN 100400069 C CN100400069 C CN 100400069C
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- 239000003814 drug Substances 0.000 title claims abstract description 42
- 229940079593 drug Drugs 0.000 title claims description 10
- 238000002360 preparation method Methods 0.000 title claims description 9
- 230000001850 reproductive effect Effects 0.000 claims abstract description 12
- 241000005787 Cistanche Species 0.000 claims abstract description 8
- 210000000582 semen Anatomy 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000190633 Cordyceps Species 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 241000234276 Curculigo Species 0.000 abstract 1
- 240000007371 Cuscuta campestris Species 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 description 8
- 230000004899 motility Effects 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 230000021595 spermatogenesis Effects 0.000 description 5
- 239000002775 capsule Substances 0.000 description 4
- 230000002381 testicular Effects 0.000 description 4
- 208000007466 Male Infertility Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000019100 sperm motility Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010021929 Infertility male Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 239000008783 wuzi yanzong Substances 0.000 description 2
- 208000027205 Congenital disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
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- 239000003098 androgen Substances 0.000 description 1
- 230000001548 androgenic effect Effects 0.000 description 1
- 230000000469 anti-sperm effect Effects 0.000 description 1
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- 230000003203 everyday effect Effects 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
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- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000023508 male gonad development Effects 0.000 description 1
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- 230000005855 radiation Effects 0.000 description 1
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- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 230000009329 sexual behaviour Effects 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 239000008925 shengjing Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 201000004822 varicocele Diseases 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine for promoting and protecting male reproductive capacity, which is characterized in that the medicine is prepared from 16 to 48 parts of red sage root, 18 to 24 parts of prepared fleeceflower root, 8 to 24 parts of desertliving cistanche, 10 to 24 parts of curculigo rhizome, 12 to 36 parts of epimedium herb, 16 to 48 parts of barbary wolfberry fruit, 10 to 24 parts of acanthopanax bark, 16 to 48 parts of dodder and 4 to 16 parts of aweto by weight. The medicine has the advantages of convenient use, quick effect taking, high clinic cure rate and no side effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of male sterility, particularly relate to the medicine that a kind of treatment male reproductive function that with the botanical herbs is raw material is made descends.
Background technology
Male reproductive function descends or male sterility is one of common clinical, mainly shows as the sperm quantity deficiency, and motility of sperm and motility rate are low.Have a strong impact on human procreation ability and prenatal and postnatal care, this phenomenon has caused the great attention of the national health organization of connection.China's traditional treatment male reproductive function descends, and how oral based on the herbal decoction piece decoction, this method is used inconvenience, and mouthfeel is poor, and the active ingredient that decocts out is abundant inadequately, and therapeutic effect is undesirable.At present, though the Chinese medicinal capsule of existing spermatogenesis occurs, these medicines have certain therapeutical effect to sperm quantity, quality, but spermatogenesis class Chinese patent medicine prescription in the past is numerous and diverse, specific aim is poor, and effect is not ideal enough, more than the SHENGJING JIAONANG prescription drug 19 that has is distinguished the flavor of, it is outstanding inadequately to cure mainly medicine, and wherein the part medicine does not have the pharmacological action of spermatogenesis.The Chinese patent medicine that some are traditional, as " WUZIYANZONG WAN " etc., curative effect is relatively poor, more is difficult at present male because of multiple pollution such as environment, food, radiation, medicine with rhythm of life is too fast, psychentonia, the treatment that the overweight male reproductive function that waits undesirable element to cause of pressure descends.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that promotes and protect male reproductive function.With traditional dialectical be criterion, the method negative and positive of the kidney invigorating are taken into account, the act of replenishing essence is made a distinction between the important and the lesser one, assistant increases the Chinese medicine Cordyceps that has at promoting testicular function to unclog and readjust in 8 kinds of Chinese herbal medicine among the nourishing, also meets the modern principles of formulating prescriptions of treatment according to differentiation of diseases simultaneously.
The present invention realizes with following technical scheme: a kind of medicine that promotes to protect male reproductive function is characterized in that it is to make with conventional preparation method with following raw medicaments in portion by weight: Radix Salviae Miltiorrhizae 16-48 part, Radix Polygoni Multiflori Preparata 8-24 part, Herba Cistanches 8-24 part, Rhizoma Curculiginis 10-24 part, Herba Epimedii 12-36 part, Fructus Lycii 16-48 part, Cortex Acanthopancis 10-24 part, Semen Cuscutae 16-48 part, Cordyceps 4-16 part.
Above-mentioned raw materials medicine and consumption are that the inventor just draws through repeated tests, all have significant curative effect in above-mentioned amount ranges.
Radix Salviae Miltiorrhizae has the effect of blood circulation promoting and blood stasis dispelling, blood circulation promoting in the side, can increase the blood flow of testis, and testicular function is had the raising effect; Radix Polygoni Multiflori Preparata invigorating the liver and kidney, benefiting essence-blood, animal experiment confirms adrenal gland, the thyroid function effect of being improved to Aged Mice, and good anti-senescence function is arranged; Herba Cistanches the kidney warming benefit is smart, braces up energy and delay senility, and can improve sexual behaviour frequency and sexualities such as copulation and ejaculation to male mice; Herba Epimedii the kidney warming benefit is smart, and QI invigorating is kept fit, and the prostate of animal, seminal vesicle weight are increased, and similar androgenic effect is arranged, and can increase gonepoiesis, and is useful to improving motility of sperm and quantity; Rhizoma Curculiginis temperature compensation Liver and kidney and bone and muscle strengthening, animal experiment has androgen-like action; Fructus Lycii nourishing kidney QI invigorating, tonifying liver is kept fit, and slow down aging improves fertility; The Semen Cuscutae nourishing the liver and kidney, the spermatogenesis of promotion animal is useful to the quality and quantity that improves sperm; Cortex Acanthopancis temperature compensation Liver and kidney, the animal experiment proof can promote male gonad development, has good androgen sample effect; The smart QI invigorating of Cordyceps benefit, life lengthening can make rabbit testicular weight and testicular weight index obviously improve, and has good spermatogenesis and anti-sperm distortion effect.This side combination, negative and positive are all mended, and temperature and not dry is grown and oiliness, male reproductive function is had very significantly promote and protective effect.
Medical material in the said medicine can be adopted the conventional method of Chinese medicine preparation, add adjuvant and can make various oral formulations,, all not influence its therapeutic effect as granule, tablet, pill, capsule, electuary, oral liquid.
The present invention preferably adopts following capsule formulation and tablet.
The preparation method of described medicine, carry out as follows:
(1) weighting raw materials in proportion, standby;
(2) getting Semen Cuscutae adds water and decocts to blow to Semen Cuscutae with pressure cooker and be advisable
(3) Semen Cuscutae that step (2) is blown decocts with water 5 times together with Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Herba Cistanches, Herba Epimedii, Fructus Lycii, Rhizoma Curculiginis and the Cortex Acanthopancis 7 flavor medicines of decocting liquid and described weight ratio, merges 5 times decocting liquid;
(4) get Cordyceps and decoct with water 5 times, merge 5 times decocting liquid;
(5) step (3), (4) gained decocting liquid are condensed into extractum after merging;
(6) extractum is dried dry extract;
(7) pulverize the dry extract powdering;
(8) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(9) incapsulate.
Each amount of water of described step (3) and step (4) was not advisable to have powder, decocted 30 minutes at every turn.
Described step (7) gained medicated powder and tablet adjuvant commonly used is mixed, and tabletting becomes tablet.
Medicine of the present invention shows that through clinical use result following advantage is arranged:
1, to select the natural edible-plant medicine for use be crude drug in the present invention, and each component meets Medicine Act regulation and tcm prescription principle, gives prominence to the dialectical characteristic that combines with differential diagnosis of diseases.
2, medicine of the present invention need not decoct, good mouthfeel, and taking convenience, medicine is nontoxic, and normal dose is taken and is not found any side effect, and onset is rapid.
3, medicine of the present invention descends to male reproductive function not only excellent curative, and the good preventing protective effect is also arranged, and is applicable to the reproductive performance protection adverse circumstances work male.
4, medicine of the present invention has good effect to male sexual disorder.
5, medicament composing prescription flavour of a drug of the present invention are few relatively, avoided square big medicine to have more existing combination untoward reaction, and emphasis is more outstanding.
The specific embodiment
Add up the effect that further specifies medicine of the present invention below in conjunction with embodiment and clinical practice.
Embodiment 1: the capsule preparation
Radix Salviae Miltiorrhizae 24kg, Radix Polygoni Multiflori Preparata 15kg, Herba Cistanches 15kg, Herba Epimedii 20kg, Rhizoma Curculiginis 15kg, Fructus Lycii 24kg, Cortex Acanthopancis 15kg are added the common decoction of entry 5 times, add water at every turn and be not advisable, decocted 30 minutes at every turn, merge 5 times decocting liquid to have powder; Semen Cuscutae 24kg is put into pressure cooker decocts to Semen Cuscutae and blow mouth, in the lump with the said herbal medicine decoction pieces with frying in shallow oil; Do not have the decocting of powder to boil 5 times Cordyceps 10kg adding, each 30 minutes, merged 5 times decocting liquid; Then two kinds of decocting liquids are condensed into extractum; Be dried into dry extract then, again dry extract be broken into fine powder and incapsulate, every medicated powder 0.45g.
Embodiment 2: preparation tablets
With Radix Salviae Miltiorrhizae 10kg, Radix Polygoni Multiflori Preparata 20kg, Herba Cistanches 20kg, Herba Epimedii 25kg, Rhizoma Curculiginis 10kg, Fructus Lycii 40kg, Cortex Acanthopancis 20kg, Cordyceps 8kg, Semen Cuscutae 40kg, make medicated powder with embodiment 1 described method, be aided with tablet adjuvant commonly used again and make tablet.
This clinical drug is observed
One, ordinary circumstance and test method
For confirming the clinical efficacy of medicine of the present invention, year July in January, 2005-2005, select sperm quantity to be lower than 2,000 ten thousand/ml, sperm motility rate＜30%, motility of sperm A level＜10% or A level+B level＜25%, get rid of varicocele, male infertility 162 examples of congenital diseases are divided into medication therapy groups of the present invention (hereinafter to be referred as the treatment group) and matched group at random, and the former establishes matched group 1 example at per 2 examples, treatment group 108 row, matched group 54 examples.The treatment group is taken embodiment 1 medicament capsule, and every day 3 times, each 4, the matched group routine dose is taken LIUWEI DIHUANG WAN, WUZIYANZONG WAN.3 months is a course of treatment, carries out the seminal fluid routine examination 2 times in 1 month after the drug withdrawal, gets meansigma methods 2 times.
Two, clinical observation standard is: above-mentioned three indexs through treating its wife's pregnancy or seminal fluid routine all reach normal person for curing; Sperm quantity＞4,000 ten thousand/ml, sperm motility rate＞50%, motility of sperm A level sperm＞20% or A level+B level＞40% is a produce effects; Sperm quantity, sperm motility rate, motility of sperm all rise to effectively than raising or one of them index before the treatment; Treatment back These parameters does not have raising or the descender is invalid.
Three, observed result shows, the treatment group is cured 60 examples, produce effects 32 examples, and effective 12 examples, invalid 4 examples, total effective rate is 96.29%; Matched group is cured 5 examples, produce effects 13 examples, and effective 22 examples, invalid 14 examples, total effective rate is 74.07%.Learn by statistics and handle, both obvious effective rates have significant difference, P＜0.01.
Claims (4)
1. one kind promotes and the medicine of protection male reproductive function, it is characterized in that it is to make with conventional preparation method extraction with following raw medicaments in portion by weight:
Radix Salviae Miltiorrhizae 16-48 part Radix Polygoni Multiflori Preparata 8-24 part Herba Cistanches 8-24 part
Rhizoma Curculiginis 10-24 part Herba Epimedii 12-36 part Fructus Lycii 16-48 part
Cortex Acanthopancis 10-24 part Semen Cuscutae 16-48 part Cordyceps 4-16 part.
2. method for preparing the described medicine of claim 1 is characterized in that carrying out as follows:
(1) weighting raw materials in proportion, standby;
(2) getting Semen Cuscutae adds water and decocts to blow to Semen Cuscutae with pressure cooker and be advisable;
(3) Semen Cuscutae that step (2) is blown decocts with water 5 times together with Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori Preparata, Herba Cistanches, Herba Epimedii, Fructus Lycii, Rhizoma Curculiginis and the Cortex Acanthopancis 7 flavor medicines of decocting liquid and described weight ratio, merges 5 times decocting liquid;
(4) get Cordyceps and decoct with water 5 times, merge 5 times decocting liquid;
(5) step (3), (4) gained decocting liquid are condensed into extractum after merging;
(6) extractum is dried dry extract;
(7) pulverize the dry extract powdering;
(8) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(9) incapsulate.
3. the method for preparing medicine according to claim 2 is characterized in that each amount of water of step (3) and step (4) was not advisable to have powder, decocts 30 minutes at every turn.
4. preparation method according to claim 2 is characterized in that step (7) gained medicated powder and tablet adjuvant commonly used is mixed, and tabletting becomes tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510123117XA CN100400069C (en) | 2005-12-13 | 2005-12-13 | Medicine for improving and protecting male genitality and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510123117XA CN100400069C (en) | 2005-12-13 | 2005-12-13 | Medicine for improving and protecting male genitality and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1824087A CN1824087A (en) | 2006-08-30 |
| CN100400069C true CN100400069C (en) | 2008-07-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200510123117XA Expired - Fee Related CN100400069C (en) | 2005-12-13 | 2005-12-13 | Medicine for improving and protecting male genitality and its preparation method |
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| Country | Link |
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| CN (1) | CN100400069C (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055227C (en) * | 1996-09-16 | 2000-08-09 | 王�琦 | Medicine for treating masculine sterility |
| CN1094372C (en) * | 1997-06-05 | 2002-11-20 | 廖开福 | Liquor for strengthening Yang |
-
2005
- 2005-12-13 CN CNB200510123117XA patent/CN100400069C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055227C (en) * | 1996-09-16 | 2000-08-09 | 王�琦 | Medicine for treating masculine sterility |
| CN1094372C (en) * | 1997-06-05 | 2002-11-20 | 廖开福 | Liquor for strengthening Yang |
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| Publication number | Publication date |
|---|---|
| CN1824087A (en) | 2006-08-30 |
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Granted publication date: 20080709 Termination date: 20121213 |