CN100434106C - Chinese medicinal composition for treating climacteric syndrome and application thereof - Google Patents
Chinese medicinal composition for treating climacteric syndrome and application thereof Download PDFInfo
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- CN100434106C CN100434106C CNB2004100180975A CN200410018097A CN100434106C CN 100434106 C CN100434106 C CN 100434106C CN B2004100180975 A CNB2004100180975 A CN B2004100180975A CN 200410018097 A CN200410018097 A CN 200410018097A CN 100434106 C CN100434106 C CN 100434106C
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Abstract
The present invention relates to a Chinese medicine composition which comprises 0.2 to 50 portions of Chinese angelica root, 0.2 to 50 portions of tree peony bark, 0.2 to 100 portions of prepared rhizome of rehmannia, 0.2 to 100 portions of epimedium, 0.2 to 50 portions of blackend swallowwort root, 0.2 to 100 portions of patrinia herb and 0.2 to 50 portions of anemarrhena rhizome. The present invention also relates to an application of the Chinese medicine composition in preparing medicines for treating menopausal syndromes. The Chinese medicine composition can be used as the substitute of the hormone replacement therapy (HRT) so as to treat or relieve the symptoms such as hectic fevers, sweatiness, fidget, etc. of women in menopausal periods.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of the syndrome in menopause.The invention still further relates to the purposes of described Chinese medicine composition in pharmacy.
Background technology
Along with whole society's health and growth in the living standard, 1/3 time of modern female life will be spent after menopause, and syndrome in menopause in various degree can appear in many people.
Hormone Replacement Therapy (hormone replacement therapy abbreviates HRT below as) has been considered to the optimal treatment hands section of syndrome in menopause always since advocating use from 1996; The HRT medicine is widely used in treating the syndrome in menopause.
In July, 2002, NIH (NIH) announces, the disadvantages outweigh the advantages to use HRT through 5 years discover, compare with placebo, use HRT can make stroke incidence increase by 40%, the coronary heart attack rate increases by 29%, and the venous thrombosis rate increases by 100%, and total cardiovascular disease increases by 22%.In December, 2002, U.S. government announces the carcinogen that the main medicine estrogen of HRT is " known ".Therefore, this technical field need be sought safe and effective HRT succedaneum as soon as possible to remove the puzzlement of perimenopausal women.
Be present in leguminous plant and trefoil Daidezin, Radix Puerariae flavone, genistein and be present in the fructovegetative enterolactone of pod and enterodiol similar because of its structure and function and estrogen, with β estrogen receptor affinity rate height, be called as " natural estrogen ".Therefore, from natural plants, seek the HRT succedaneum and become pursuing one's goal of Chinese scholars in recent years.
The Chinese herbal treatment syndrome in menopause that derives from natural plants is of long standing and well established, and menopause, syndrome belonged to the traditional Chinese medical science " pre-postmenstrual syndromes " category.Part can belong to diseases such as " old postmenopausal menstruation ", " dirty dry ", " Bulbus Lilii syndrome ".The kidney qi degradation, menses will exhaust, and dash and appoint loss, asthenia of essence and blood, imbalance of YIN and YANG is the etiology and pathogenesis of this disease.But, up to now, still do not have the succedaneum of suitable effective Chinese medicine composition as the HRT of long-term or short-term.
(3) summary of the invention
An object of the present invention is to provide a kind of is rule with " adjust the dual power of negative and positive principles ", the row treating YANG within YIN, the art for the treatment of YIN within YANG, in the hope of equilibrium between yin and yang, release a kind of have to cut down hold back asthenic fire, grow the wet kidney of water, the Yin Yang balancing effect, as long-term or short-term HRT succedaneum, with the Chinese medicine composition of treatment syndrome in menopause.
The present invention also relates to the application of this Chinese medicine composition in the medicine of preparation treatment syndrome in menopause.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Radix Angelicae Sinensis 0.2-50 Cortex Moutan 0.2-50
Radix Rehmanniae Preparata 0.2-100 Herba Epimedii 0.2-100
Radix Cynanchi Atrati 0.2-50 Herba Patriniae 0.2-100
Rhizoma Anemarrhenae 0.2-50
The optimum weight of Chinese medicine composition of the present invention (part) proportioning is:
Radix Angelicae Sinensis 15 Cortex Moutans 15
Radix Rehmanniae Preparata 15 Herba Epimedii 30
Radix Cynanchi Atrati 15 Herba Patriniae 30
The Rhizoma Anemarrhenae 15
When the root that is classified as Umbelliferae herbaceos perennial Radix Angelicae Sinensis, ground such as main product Gansu, Yunnan, Sichuan, Shanxi are used as medicine with dry root.Nature and flavor suffering, sweet, little hardship, temperature, GUIXIN, liver, spleen channel, it can be enriched blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Cortex Moutan is ground such as the root bark of the perennial machaka Paeonia suffruticosa of Ranunculaceae, main product Anhui, Shandong, Sichuan, Hubei, Shaanxi, is used as medicine with dry root bark.Nature and flavor suffering, hardship, be slightly cold, temperature, GUIXIN, liver, kidney channel, it can clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis.
The Rhizoma Anemarrhenae is a Liliaceae herbaceos perennial Rhizoma Anemarrhenae rhizome, ground such as main product Hebei, Shanxi, northeast.Be used as medicine with dry rhizome.Nature and flavor hardship, sweet, cold is returned lung, stomach, kidney channel, and its energy clearing heat, purging intense-heat is nourshing Yin and drynsessmoistening prescription.
Radix Cynanchi Atrati is the root of upright Radix Cynanchi Atrati of asclepiadaceae herbaceos perennial or Cynanchum versicolor Bunge, and ground such as main product Liaoning, Shaanxi, Shandong, Anhui are used as medicine with dry rhizome.Nature and flavor hardship, salty, cold is returned stomach, Liver Channel, and it can removing heat from blood be brought down a fever, but term epidemic febrile disease later stage, vomiting.
Herba Patriniae is the whole herb with root of Valerianaceae herbaceos perennial patrima villosa or Patrinia scabiosaefolia Fisch.Ground such as main product Sichuan, Jiangxi, Fujian, Anhui are with dry all herbal medicine.Nature and flavor suffering, hardship, be slightly cold, return stomach, large intestine, Liver Channel, it can heat-clearing and toxic substances removing, the silt pain relieving of dispelling.
Radix Rehmanniae Preparata is the tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae, steams the copy that shines through mixing with yellow wine, is used as medicine with copy.The property mildly bitter flavor, sweet tepor, GUIXIN, liver, kidney channel, it can tonifying blood and regulating menstruation, enriching yin and nourishing kidney.
Herba Epimedii is the herb of XIAONIE section herbaceos perennial Herba Epimedii.Ground such as main product Sichuan, Hunan, Hubei, Shaanxi, Shanxi, Liaoning are with dry all herbal medicine.Nature and flavor suffering, sweet, warm is returned liver, kidney channel, its energy kidney invigorating and YANG supporting, expelling wind and removing dampness.
Be monarch drug with the Rhizoma Anemarrhenae in the Chinese medicine composition of the present invention, Radix Rehmanniae Preparata is a ministerial drug, and Cortex Moutan is for the assistant adjuvant drug, when being classified as messenger drug.
Chinese medicine composition of the present invention can be used for treating symptom show as " the hectic fever sweating, irritated irritability ", dialectical is the syndrome patient in menopause of deficiency of the kidney yin, accounts for more than 95% of syndrome patient in whole menopause and show as the deficiency of the kidney yin symptom.
Therefore, another aspect of the present invention relates to the application of Chinese medicine composition of the present invention in the medicine of syndrome in the menopause of preparation treatment deficiency of the kidney yin.
Chinese medicine composition of the present invention can be concentrating agents form or electuary form.The concentrating agents for preparing Chinese medicine composition of the present invention like this: 0.2-50 weight portion Radix Angelicae Sinensis, 0.2-50 weight portion Cortex Moutan, 0.2-100 weight portion Radix Rehmanniae Preparata, 0.2-100 weight portion Herba Epimedii, 0.2-50 weight portion Radix Cynanchi Atrati, 0.2-100 weight portion Herba Patriniae and the 0.2-50 weight portion Rhizoma Anemarrhenae were soaked 1 hour, decoct 2 times, each 1 hour, to pour into non-toxic plastic bag after suitably concentrating standby in addition again.Preferably, after this medicine cooling, put into refrigerator.
The electuary for preparing Chinese medicine composition of the present invention like this: 1.0.2-50 weight portion Radix Angelicae Sinensis water steamer is collected its volatile oil, and is standby;
2. the Radix Angelicae Sinensis residue is mixed with 0.2-50 weight portion Cortex Moutan, 0.2-100 weight portion Radix Rehmanniae Preparata, 0.2-100 weight portion Herba Epimedii, 0.2-50 weight portion Radix Cynanchi Atrati, 0.2-100 weight portion Herba Patriniae and the 0.2-50 weight portion Rhizoma Anemarrhenae, soaked 1 hour, and decocted each 1 hour 2 times, admixing medical solutions, filter, filtrate is condensed into cream, the cream man dextrin uniform mixing of getting it filled, make soft material, cross 12 mesh sieves and granulate, 60 ℃ of oven dry down, granulate.
3. Radix Angelicae Sinensis volatile oil is sprayed on the granule with nebulization, airtight 6 hours, pack got final product.
Be described in further detail technical scheme of the present invention below in conjunction with specific embodiment.
The specific embodiment
Embodiment 1
7.5 gram Radix Angelicae Sinensis, 7.5 gram Cortex Moutans, 7.5 gram Radix Rehmanniae Preparata, 15 gram Herba Epimedii, 7.5 gram Radix Cynanchi Atratis, 15 gram Herba Patriniae and the 7.5 gram Rhizoma Anemarrhenaes were soaked 1 hour, is decocted 2 times, each 1 hour, it was standby to pour into non-toxic plastic bag after in addition suitably concentrated again.
Embodiment 2
7.5 gram Radix Angelicae Sinensis water steamer is collected its volatile oil, and is standby; The Radix Angelicae Sinensis residue is mixed with 7.5 gram Cortex Moutans, 7.5 gram Radix Rehmanniae Preparata, 15 gram Herba Epimedii, 7.5 gram Radix Cynanchi Atratis, 15 gram Herba Patriniae and the 7.5 gram Rhizoma Anemarrhenaes, soaked 1 hour, and decocted each 1 hour 2 times, admixing medical solutions, filter, filtrate is condensed into cream, the cream man dextrin uniform mixing of getting it filled, make soft material, cross 12 mesh sieves and granulate, 60 ℃ of oven dry down, granulate.Radix Angelicae Sinensis volatile oil is sprayed on the granule with nebulization, and airtight 6 hours, pack got final product.
The clinical implementation example
The women that to choose the mean age be 49.82 ± 10.336, have a deficiency of YIN symptoms such as hectic fever sweating, irritated irritability is totally 50 examples, to the preceding E that takes medicine of 36 routine patients wherein
2(estradiol) and FSH (flitropin) measure, and the result is:
E
2(pg/ml)21.28±42.21
Conventional standard value in menopause: E
2(pg/ml)＜40
FSH(mIu/ml)84.14±47.22
Conventional standard value in menopause: FSH (mIu/ml) 25.8-134.8
In the selected subjects, uterus and ovarian disease patient 8 people, hypertension 11 people, hyperlipidemia merges high blood viscosity person 2 people.
The absolute contraindication of HRT: breast carcinoma, carcinoma of endometrium, melanoma, agnogenic colporrhagia, serious hepatic and renal function injure, thrombotic disease, lupus erythematosus, hematoporphyria, otosclerosis, meningioma.
The relative contraindication of HRT: hysteromyoma, endometrial thickness, endometriosis, disease of hyperplasia of mammary glands glands, hypertension, diabetes, cholecystitis, coronary heart disease and potential risk factor thereof (hyperlipidemia, metabolic syndrome, sclerosis of blood vessels), malignant tumor.
Take one bag of the product that embodiment 1 prepares every day, twice of every day.
The treatment group gives the Chinese medicine composition of the embodiment of the invention 1 preparation.
The 7-14 that takes medicine pays back doing well,improving situation in the recent period:
85% patient's hectic fever, sweating, irritated doing well,improving, the improvement rate surpasses more than 50%.
Symptom after taking medicine improves time of occurrence: took medicine back 7 days.
Symptom after taking medicine improves the persistent period: 3-4 week
Take medicine and 5 routine patients are carried out the E second time after 14 pairs
2And FSH measures result and for the first time similar.
Do not find irregular vagina bleeding, distending pain of the breast after taking medicine, feel sick etc. taken the reaction of HRT.
It is similar with use HRT class medicine (Weinian, the 4mg/ month) the 20-30 days period to the improvement degree of cardinal symptom that Chinese medicine composition of the present invention is taken in patient's reflection.
This shows that Chinese medicine composition of the present invention not only can be used as the succedaneum of HRT, symptoms such as the hectic fever that treatment or alleviation perimenopausal women occur, sweating, agitation.In addition, owing to do not contain any estrogen and estrogen-like product in the Chinese medicine composition of the present invention, so can not produce side effect such as the irregular colporrhagia that is suitable for HRT and occurs, distending pain of the breast after taking medicine.
Claims (5)
1. Chinese medicine composition for the treatment of the syndrome in menopause, it is to be that the raw material of weight portion is made by following consumption:
Radix Angelicae Sinensis 0.2-50 Cortex Moutan 0.2-50
Radix Rehmanniae Preparata 0.2-100 Herba Epimedii 0.2-100
Radix Cynanchi Atrati 0.2-50 Herba Patriniae 0.2-100
Rhizoma Anemarrhenae 0.2-50.
2. the Chinese medicine composition of treatment syndrome in menopause according to claim 1 wherein ought be classified as 15 weight portions, and Cortex Moutan is 15 weight portions, Radix Rehmanniae Preparata is 15 weight portions, and Herba Epimedii is 30 weight portions, and Radix Cynanchi Atrati is 15 weight portions, Herba Patriniae is 30 weight portions, and the Rhizoma Anemarrhenae is 15 weight portions.
3. the Chinese medicine composition of treatment syndrome in menopause according to claim 1 and 2, it is concentrating agents form or electuary form.
4. the application of Chinese medicine composition as claimed in claim 1 in the medicine of preparation treatment syndrome in menopause.
5. application according to claim 4, wherein said menopause, syndrome was hectic fever, sweating, irritated symptom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100180975A CN100434106C (en) | 2004-04-30 | 2004-04-30 | Chinese medicinal composition for treating climacteric syndrome and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100180975A CN100434106C (en) | 2004-04-30 | 2004-04-30 | Chinese medicinal composition for treating climacteric syndrome and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1689597A CN1689597A (en) | 2005-11-02 |
| CN100434106C true CN100434106C (en) | 2008-11-19 |
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| CNB2004100180975A Expired - Fee Related CN100434106C (en) | 2004-04-30 | 2004-04-30 | Chinese medicinal composition for treating climacteric syndrome and application thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897881B (en) * | 2010-07-29 | 2011-11-09 | 河南中医学院 | Traditional Chinese medicine for treating menopausal syndrome |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176794A (en) * | 1996-09-16 | 1998-03-25 | 王�琦 | Medicine for treating masculine sterility |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176794A (en) * | 1996-09-16 | 1998-03-25 | 王�琦 | Medicine for treating masculine sterility |
Non-Patent Citations (2)
| Title |
|---|
| 温通散治疗输卵管不畅98例. 虎发光.安徽中医学院学报，第13卷第3期. 1994 |
| 温通散治疗输卵管不畅98例. 虎发光.安徽中医学院学报，第13卷第3期. 1994 * |
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| CN1689597A (en) | 2005-11-02 |
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Granted publication date: 20081119 Termination date: 20130430 |