CN1205974C - Thirty-six ingredients capsule for treating diabetes - Google Patents

Thirty-six ingredients capsule for treating diabetes Download PDF

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Publication number
CN1205974C
CN1205974C CNB031013163A CN03101316A CN1205974C CN 1205974 C CN1205974 C CN 1205974C CN B031013163 A CNB031013163 A CN B031013163A CN 03101316 A CN03101316 A CN 03101316A CN 1205974 C CN1205974 C CN 1205974C
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radix
gram
powder
grams
rhizoma
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CN1429612A (en
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施今墨
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Guangxi Baiqi Pharmaceutical Co ltd
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BEIHAI KAIYUN PHARMACEUTICAL Co Ltd
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Abstract

The present invention discloses a capsule containing thirty six kinds of ingredients for treating diabetes, which is a medicine for treating diabetes. At present, common medicines for treating diabetes often increase the workload of beta cells to satisfy the requirements of human bodies to insulin and uses blood sugar reduction as a main purpose to stimulate the beta cells in order to increase the amount of secretion and realize the treatment of diabetes. The present invention is composed of thirty six kinds of ingredients of traditional Chinese medicines. The present invention not only can comprehensively treat various symptoms of diabetes, but also can make pancreata restore normally and prevent complicating diseases from occurring. Through the clinical verification of 120 cases, the total effective rate of the present invention is 85.8%.

Description

A kind of pharmaceutical composition for the treatment of diabetes
What the present invention relates to is a kind of pharmaceutical composition of the treatment diabetes of being made up of 36-flavor Glutinous Chinese medicine.
Diabetes are a kind of commonly encountered diseases, also are a kind of diseases of difficult healing.The medicine that is usually used in treating diabetes at present has several like this classes: sulfanilamide ureas, biguanides, Chinese medicine and western medicine mixture and Chinese medicine blood sugar lowering class.Above-mentioned these a few class medicines all have certain therapeutical effect.But also exist certain deficiency simultaneously.They usually are to strengthen remaining cell, mainly are that the workload of β cell satisfies the demand of human body to insulin, are main purpose with the blood sugar lowering, finish to stimulate the β cell to strengthen secretory volume, and this just has the irrationality of two aspects.1. be to cause the decline day by day under stimulating of β cell, so will increase the demand that dosage satisfies blood sugar lowering gradually, last this stimulation is inoperative, so just need insulin injection, this just makes the β cell function day by day die down until inoperative; 2. be the method that stimulates the β cell merely, mainly be with the blood sugar lowering be purpose to have ignored diabetes are facts of three big metabolism disorders, thereby in blood sugar control, but can not stop the generation of complication.Here it is is used for the treatment of the existing deficiency of medicine of diabetes at present, at these deficiencies, is studied, and seeks a kind of better medicine and is the present invention and be devoted to the problem that will solve.
Purpose of the present invention prepares a kind of various diseases that can comprehensively treat diabetes exactly, the medicament that can recover the normal of pancreas again and can stop complication to take place.
For achieving the above object, the present invention has taked such measure: a kind of pharmaceutical composition for the treatment of diabetes is the capsules that are prepared from by the following weight proportion raw material:
Radix Panacis Quinquefolii 0.8-1.2 part Radix Scrophulariae 1.6-2.4 part Radix Asparagi 1.6-2.4 part
Herba Dendrobii 1.6-2.4 part 1.6-2.4 Radix Ophiopogonis part Leptoradix Ginseng Rubra 0.8-1.2 part
Radix Astragali 3.2-4.8 part Fructus Schisandrae Chinensis 0.8-1.2 part Fructus Lycii 2.4-3.6 part
Rhizoma Polygonati Odorati 1.6-2.4 part Radix Rehmanniae 0.8-1.2 part Radix Rehmanniae Preparata 0.8-1.2 part
Radix Polygoni Multiflori Preparata 1.6-2.4 part Colla Corii Asini 1.6-2.4 part Radix Paeoniae Alba 1.6-2.4 part
Rhizoma Polygonati 1.6-2.4 part Arillus Longan 1.6-2.4 part Rhizoma Atractylodis Macrocephalae 1.6-2.4 part
Rhizoma Atractylodis 1.6-2.4 part is fried Semen Coicis 1.6-2.4 part Rhizoma Dioscoreae 2.4-3.6 part
1.6 2.4 parts of Radix Achyranthis Bidentatae 0.8-1.2 of Fructus Corni part Rhizoma Cibotii 1.6-2.4 part
Rhizoma Coptidis 0.8-1.2 part Cortex Phellodendri 1.6-2.4 part Cortex Lycii 2.4-3.6 part
Radix Cynanchi Atrati 0.8-1.2 part Spica Prunellae 0.8-1.2 part Fructus Tribuli 1.6-2.4 part
Radix Trichosanthis 24.-3.6 part Radix Puerariae 0.8-1.2 part Indigo Naturalis 0.08-0.2 part
Concha Meretricis seu Cyclinae 0.7-1.2 part Radix Salviae Miltiorrhizae 1.6-2.4 part Herba Lycopi 0.8-1.2 part
Above-mentioned medical material is except that Radix Panacis Quinquefolii, Leptoradix Ginseng Rubra, Colla Corii Asini, Semen Coicis, Concha Meretricis seu Cyclinae, Indigo Naturalis, its excess-three ten flavor medicines add the water heating extraction, extracting solution concentrates the back and adds ethanol to carry out wine heavy, gets supernatant again and reclaims and detect to such an extent that relative density is that the thick paste of 1.20-1.40 is standby when reconcentration is to 50-60 ℃ behind the ethanol.It is standby to get above-mentioned Six-element medicine pulverize separately.Five tastes medicated powder mix homogeneously such as above-mentioned thick paste and red ginseng powder, Colla Corii Asini powder, Semen Coicis powder, Concha Meretricis seu Cyclinae powder, Indigo Naturalis and the drying and crushing powder that gets dry extract is standby.Get final product incapsulating after Radix Panacis Quinquefolii powder and dried cream powder and appropriate amount of auxiliary materials mix homogeneously and the drying again.
Also can granulate behind above-mentioned dried cream powder and the Radix Panacis Quinquefolii powder mix homogeneously, can make granule with the appropriate amount of auxiliary materials mix homogeneously.
Behind above-mentioned dried cream powder and the Radix Panacis Quinquefolii powder mix homogeneously also can with appropriate amount of auxiliary materials mix homogeneously pelletizing press sheet.Can make tablet.
Adopt the present invention of above-mentioned measure, can nourish, repair impaired pancreas, recovery exocrine pancreas glandular secretion lipase, tryptic normal function, recovery alpha Cell of islet, β cell, gamma cells are normally secreted the ability of glucagon, insulin, growth hormone, release inhibting hormone, thereby are impelled the balance of glycolipid fat, protein three big metabolic functions.Can treat the heart relevant, eye, kidney, blood vessel and neural syndrome, recover blood glucose balance of nature with diabetes.Confirm that through clinical verification the present invention has the effect of supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid, the diabetes (diabetes) that can be used for syndrome of deficiency of both qi and yin, inspection such as disease such as treatment back patient's fatigue and asthenia, the lazy speech of breathing hard, spontaneous perspiration, night sweat, thirst and liking drink, dysphoria with feverish sensation in the chest palms and soles, cardiopalmus, red, the constipation of having a sleepless night, urinate and fasting glucose, 2 hours after the meal blood glucose, twenty-four-hour urine sugar are quantitative all have clear improvement (p<0.01).Clinical verification 120 examples, aggregate efficiency are 85.8%.With matched group curative effect no significant difference (p<0.05).The present invention is safe and reliable, no obvious adverse reaction and toxic and side effects.
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment 1
Prescription:
Radix Panacis Quinquefolii 16 gram Radix Scrophulariaes 32 gram Radix Asparagis 32 grams
Herba Dendrobii 32 gram 32 gram Leptoradix Ginseng Rubra Radix Ophiopogonis 16 grams
The Radix Astragali 64 gram Fructus Schisandrae Chinensis 16 gram Fructus Lycii 48 grams
The Rhizoma Polygonati Odorati 32 gram Radix Rehmanniae 16 gram Radix Rehmanniaes Preparata 16 grams
The Radix Polygoni Multiflori Preparata 32 gram Colla Corii Asini 32 gram Radix Paeoniae Albas 32 grams
The Rhizoma Polygonati 32 gram Arillus Longans 32 gram Rhizoma Atractylodis Macrocephalaes 32 grams
Rhizoma Atractylodis 32 grams are fried Semen Coicis 32 Keshan medicines 48 grams
Fructus Corni 3 gram Radix Achyranthis Bidentataes 16 gram Rhizoma Cibotii 32 grams
Rhizoma Coptidis 16 gram Cortex Phellodendris 32 gram Cortex Lycii 48 grams
Radix Cynanchi Atrati 16 gram Spica Prunellaes 16 gram Fructus Tribulis 32 grams
Radix Trichosanthis 48 gram Radix Puerariaes 16 gram Indigo Naturaliss 0.16 gram
Concha Meretricis seu Cyclinae 14 gram Radix Salviae Miltiorrhizaes 32 gram Herba Lycopi 1.6 grams
Preparation method:
Above-mentioned medical material is except that Radix Panacis Quinquefolii, Leptoradix Ginseng Rubra, Colla Corii Asini, Semen Coicis, Concha Meretricis seu Cyclinae, Indigo Naturalis, its excess-three ten flavor medicines add the water heating extraction, extracting solution is concentrated into 50-60 ℃ of intermittent fever and surveys, it is 75% to containing alcohol that relative density adds ethanol during for 1.15-1.20, it is heavy to carry out wine, left standstill 15-30 hour, reconcentration is surveyed to 50-60 ℃ of intermittent fever after getting supernatant and reclaiming ethanol, and relative density is that the thick paste of 1.20-1.40 is standby.It is standby to crossing the above fine powder of 120 mesh sieves to get Six-element medicine pulverize separately such as above-mentioned Radix Panacis Quinquefolii.Five tastes medicated powder mix homogeneously such as above-mentioned thick paste and red ginseng powder, Colla Corii Asini powder, Semen Coicis powder, Concha Meretricis seu Cyclinae powder, Indigo Naturalis and the drying and crushing powder that gets dry extract is standby.Get final product incapsulating after Radix Panacis Quinquefolii powder and dried cream powder and appropriate amount of auxiliary materials mix homogeneously and the drying again.The capsule loading amount is the 0.45-0.50 gram, is equivalent to crude drug amount 1.2-1.3 gram, and dose is 12 of every days, divides clothes three times.
Embodiment 2
Prescription:
Radix Panacis Quinquefolii 24 gram Radix Scrophulariaes 72 gram Radix Asparagis 72 grams
Herba Dendrobii 72 gram 72 gram Leptoradix Ginseng Rubra Radix Ophiopogonis 24 grams
The Radix Astragali 96 gram Fructus Schisandrae Chinensis 24 gram Fructus Lycii 72 grams
The Rhizoma Polygonati Odorati 72 gram Radix Rehmanniae 24 gram Radix Rehmanniaes Preparata 24 grams
The Radix Polygoni Multiflori Preparata 72 gram Colla Corii Asini 72 gram Radix Paeoniae Albas 72 grams
The Rhizoma Polygonati 72 gram Arillus Longans 72 gram Rhizoma Atractylodis Macrocephalaes 72 grams
Rhizoma Atractylodis 72 grams are fried Semen Coicis 72 Keshan medicines 72 grams
Fructus Corni 72 gram Radix Achyranthis Bidentataes 24 gram Rhizoma Cibotii 72 grams
Rhizoma Coptidis 24 gram Cortex Phellodendris 72 gram Cortex Lycii 72 grams
Radix Cynanchi Atrati 24 gram Spica Prunellaes 24 gram Fructus Tribulis 44 grams
Radix Trichosanthis 72 gram Radix Puerariaes 24 gram Indigo Naturaliss 2.4 grams
Concha Meretricis seu Cyclinae 24 gram Radix Salviae Miltiorrhizaes 72 gram Herba Lycopi 24 grams
Preparation method:
Identical with embodiment 1.
Embodiment 3:
Prescription:
Radix Panacis Quinquefolii 22 gram Radix Scrophulariaes 44 gram Radix Asparagis 44 grams
Herba Dendrobii 44 gram 44 gram Leptoradix Ginseng Rubra Radix Ophiopogonis 22 grams
The Radix Astragali 88 gram Fructus Schisandrae Chinensis 22 gram Fructus Lycii 66 grams
The Rhizoma Polygonati Odorati 44 gram Radix Rehmanniae 22 gram Radix Rehmanniaes Preparata 22 grams
The Radix Polygoni Multiflori Preparata 44 gram Colla Corii Asini 44 gram Radix Paeoniae Albas 44 grams
The Rhizoma Polygonati 44 gram Arillus Longans 44 gram Rhizoma Atractylodis Macrocephalaes 44 grams
Rhizoma Atractylodis 44 grams are fried Semen Coicis 44 Keshan medicines 66 grams
Fructus Corni 44 gram Radix Achyranthis Bidentataes 22 gram Rhizoma Cibotii 44 grams
Rhizoma Coptidis 22 gram Cortex Phellodendris 36 gram Cortex Lycii 56 grams
Radix Cynanchi Atrati 16 gram Spica Prunellaes 22 gram Fructus Tribulis 44 grams
Radix Trichosanthis 66 gram Radix Puerariaes 24 gram Indigo Naturaliss 2.2 grams
Concha Meretricis seu Cyclinae 20 gram Radix Salviae Miltiorrhizaes 44 gram Herba Lycopi 22 grams
Preparation method:
Above-mentioned medical material is except that Radix Panacis Quinquefolii, Leptoradix Ginseng Rubra, Colla Corii Asini, Semen Coicis, Concha Meretricis seu Cyclinae, Indigo Naturalis, its excess-three ten flavor medicines add the water heating extraction, extracting solution is concentrated into 50-60 ℃ of intermittent fever and surveys, it is 75% to containing alcohol that relative density adds ethanol during for 1.15-1.20, it is heavy to carry out wine, left standstill 15-30 hour, get supernatant reclaim behind the ethanol reconcentration to 50-60 ℃ of intermittent fever then, relative density is that the thick paste of 1.20-1.40 is standby.It is standby to crossing the above fine powder of 120 mesh sieves to get Six-element medicine pulverize separately such as above-mentioned Radix Panacis Quinquefolii.Five tastes medicated powder mix homogeneously such as above-mentioned thick paste and red ginseng powder, Colla Corii Asini powder, Semen Coicis powder, Concha Meretricis seu Cyclinae powder, Indigo Naturalis and the drying and crushing powder that gets dry extract is standby.Again packing after Radix Panacis Quinquefolii powder and dried cream powder and appropriate amount of auxiliary materials mix homogeneously and the drying is promptly got granule, every bag of amount is the 5-15 gram, is equivalent to crude drug amount 2.0-3.0 gram, and dose is 3-6 bag every day, divides clothes three times.
Embodiment 4:
Prescription:
Radix Panacis Quinquefolii 16 gram Radix Scrophulariaes 36 gram Radix Asparagis 36 grams
Herba Dendrobii 36 gram 36 gram Leptoradix Ginseng Rubra Radix Ophiopogonis 16 grams
The Radix Astragali 76 gram Fructus Schisandrae Chinensis 16 gram Fructus Lycii 56 grams
The Rhizoma Polygonati Odorati 36 gram Radix Rehmanniae 16 gram Radix Rehmanniaes Preparata 16 grams
The Radix Polygoni Multiflori Preparata 36 gram Colla Corii Asini 36 gram Radix Paeoniae Albas 36 grams
The Rhizoma Polygonati 36 gram Arillus Longans 36 gram Rhizoma Atractylodis Macrocephalaes 36 grams
Rhizoma Atractylodis 36 grams are fried Semen Coicis 36 Keshan medicines 56 grams
Fructus Corni 36 gram Radix Achyranthis Bidentataes 16 gram Rhizoma Cibotii 36 grams
Rhizoma Coptidis 16 gram Cortex Phellodendris 36 gram Cortex Lycii 56 grams
Radix Cynanchi Atrati 16 gram Spica Prunellaes 16 gram Fructus Tribulis 36 grams
Radix Trichosanthis 56 gram Radix Puerariaes 16 gram Indigo Naturaliss 1.6 grams
Concha Meretricis seu Cyclinae 14 gram Radix Salviae Miltiorrhizaes 36 gram Herba Lycopi 16 grams
Above-mentioned medical material is except that Radix Panacis Quinquefolii, Leptoradix Ginseng Rubra, Colla Corii Asini, Semen Coicis, Concha Meretricis seu Cyclinae, Indigo Naturalis, its excess-three ten flavor medicines add the water heating extraction, extracting solution is concentrated into 50-60 ℃ of intermittent fever and surveys, it is 75% to containing the alcohol amount that relative density adds ethanol during for 1.15-1.20, it is heavy to carry out wine, left standstill 15-30 hour, get supernatant reclaim behind the ethanol reconcentration to 50-60 ℃ of intermittent fever then, relative density is that the thick paste of 1.20-1.40 is standby.It is standby to crossing the above fine powder of 120 mesh sieves to get Six-element medicine pulverize separately such as above-mentioned Radix Panacis Quinquefolii.Five tastes medicated powder mix homogeneously such as above-mentioned thick paste and red ginseng powder, Colla Corii Asini powder, Semen Coicis powder, Concha Meretricis seu Cyclinae powder, Indigo Naturalis and the drying and crushing powder that gets dry extract is standby.With Radix Panacis Quinquefolii powder and dried cream powder and the dry back of appropriate amount of auxiliary materials mix homogeneously granulation tabletting, sheet heavily is the 0.45-0.50 gram, is equivalent to crude drug amount 1.2-1.3 gram again, and dose is 12 of every days, divides clothes three times.

Claims (3)

1, a kind of pharmaceutical composition for the treatment of diabetes is characterized in that described pharmaceutical composition is the capsule that is prepared from by the following weight proportion raw material:
Radix Panacis Quinquefolii 0.8-1.2 part Radix Scrophulariae 1.6-2.4 part Radix Asparagi 1.6-2.4 part
Herba Dendrobii 1.6-2.4 part 1.6-2.4 Radix Ophiopogonis part Leptoradix Ginseng Rubra 0.8-1.2 part
Radix Astragali 3.2-4.8 part Fructus Schisandrae Chinensis 0.8-1.2 part Fructus Lycii 2.4-3.6 part
Rhizoma Polygonati Odorati 1.6-2.4 part Radix Rehmanniae 0.8-1.2 part Radix Rehmanniae Preparata 0.8-1.2 part
Radix Polygoni Multiflori Preparata 1.6-2.4 part Colla Corii Asini 1.6-2.4 part Radix Paeoniae Alba 1.6-2.4 part
1.6 2.4 parts of Rhizoma Polygonati 1.6-2.4 part Arillus Longan 1.6-2.4 part Rhizoma Atractylodis Macrocephalaes
Rhizoma Atractylodis 1.6-2.4 part is fried Semen Coicis 1.6-2.4 part Rhizoma Dioscoreae 2.4-3.6 part
Fructus Corni 1.6-2.4 part Radix Achyranthis Bidentatae 0.8-1.2 part Rhizoma Cibotii 1.6-2.4 part
Rhizoma Coptidis 0.8-1.2 part Cortex Phellodendri 1.6-2.4 part Cortex Lycii 2.4-3.6 part
Radix Cynanchi Atrati 0.8-1.2 part Spica Prunellae 0.8-1.2 part Fructus Tribuli 1.6-2.4 part
Radix Trichosanthis 2.4-3.6 part Radix Puerariae 0.8-1.2 part Indigo Naturalis 0.08-0.2 part
Concha Meretricis seu Cyclinae 0.7-1.2 part Radix Salviae Miltiorrhizae 1.6-2.4 part Herba Lycopi 0.8-1.2 part
Above-mentioned medical material is except that Radix Panacis Quinquefolii, Leptoradix Ginseng Rubra, Colla Corii Asini, Semen Coicis, Concha Meretricis seu Cyclinae, Indigo Naturalis, its excess-three ten flavor medicines add the water heating extraction, extracting solution concentrates the back and adds ethanol to carry out wine heavy, gets supernatant again and reclaims and detect to such an extent that relative density is that the thick paste of 1.20-1.40 is standby when reconcentration is to 50-60 ℃ behind the ethanol; It is standby to get above-mentioned Six-element medicine pulverize separately; Above-mentioned thick paste and red ginseng powder, Colla Corii Asini powder, Semen Coicis powder, Concha Meretricis seu Cyclinae powder, Indigo Naturalis five tastes medicated powder mix homogeneously and the drying and crushing powder that gets dry extract is standby; Get final product incapsulating after Radix Panacis Quinquefolii powder and dried cream powder and appropriate amount of auxiliary materials mix homogeneously and the drying again.
2, the pharmaceutical composition of treatment diabetes according to claim 1 is characterized in that described feedstock production becomes the granule on the pharmaceutics meaning.
3, the pharmaceutical composition of treatment diabetes according to claim 1 is characterized in that described feedstock production becomes the tablet on the pharmaceutics meaning.
CNB031013163A 2003-01-03 2003-01-03 Thirty-six ingredients capsule for treating diabetes Expired - Lifetime CN1205974C (en)

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Application Number Priority Date Filing Date Title
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CN1205974C true CN1205974C (en) 2005-06-15

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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100396309C (en) * 2005-06-29 2008-06-25 江怀 Medicine for treating various diseases
CN101554418B (en) * 2008-04-09 2011-04-20 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating diabetic peripheral neuritis
CN101342313B (en) * 2008-08-26 2010-12-01 长沙藏谷生物科技有限公司 Health care granular formulation, preparation and application thereof
CN101637579B (en) * 2009-09-08 2011-04-27 江春德 Traditional Chinese medicine for treating diabetes mellitus and preparation method thereof
CN101972415A (en) * 2010-06-07 2011-02-16 中山市新运来医药科技开发有限公司 Traditional Chinese medicine-decocted soup or granule preparation for recuperating and treating diabetes
CN102973812B (en) * 2013-01-01 2014-04-16 辛丽娟 Pill for diabetes treatment and care
CN103386083B (en) * 2013-07-17 2015-10-28 福州永同惠生物医药科技有限公司 A kind of pharmaceutical composition for the treatment of type ii diabetes
CN104027450B (en) * 2014-06-26 2016-01-20 粟春生 A kind of Chinese medicine composition for the treatment of diabetes
CN104887908A (en) * 2015-05-16 2015-09-09 陈久洲 Traditional Chinese medicine decoction for treating diabetes
CN105396038A (en) * 2015-12-13 2016-03-16 徐士杰 A medicine for treating diabetes and a preparing method thereof
CN112336819A (en) * 2019-08-07 2021-02-09 朱维涛 Traditional Chinese medicine for treating diabetes and complications thereof

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