CN101637579B - Traditional Chinese medicine for treating diabetes mellitus and preparation method thereof - Google Patents
Traditional Chinese medicine for treating diabetes mellitus and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating diabetes mellitus and a preparation method thereof. The technical scheme is as follows: the traditional Chinese medicine comprises the following raw medical materials: astragali semen, trichosanthes, agrimony, scouring rush, astragalus, rhizoma coptidis, yam, schisandra chinensis, purslane, achyranthes aspera, azolla, salvia, gegen, white peony roots, anemarrhena, fleece-flower roots, gypsum, dodders, buntal, rehmanniae, hen egg yolk, ball cactus and silkworm chrysalis. The preparation method comprises the following steps: taking the raw medical materials by weight portions; grinding and mixing the silkworm chrysalis with the ground hen egg yolk; adding liquor; heating, refluxing, cooling and soaking to prepare medical liquid A; taking the astragalus and the rhizoma coptidis; adding liquor; heating, refluxing, cooling, pulping and soaking to prepare medical liquid B; soaking and pulping the other medical materials in the liquor; additionally adding liquor to soak and prepare medical liquid C; and mixing the medical liquid A, the medical liquid B and the medical liquid C. The invention has the functions of nourishing yin, clearing heat, activating blood and warming yang, treats both principal and secondary aspects of the disease, not only has favorable treatment effect for the diabetes mellitus, but also has obvious treatment effect on diabetes mellitus complications.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine for the treatment of diabetes particularly.
Background technology
Diabetes, the traditional Chinese medical science is called diabetes, and doctor trained in Western medicine is called diabetes.From the doctor trained in Western medicine angle: doctor trained in Western medicine is divided into three types with diabetes, and the I type is with the β cytoclasis, causes insulin definitely to lack; The II type is that insulin resistant is main, or hypoinsulinism; The III type is a specific type, comprises gestational diabetes.At present, western medical treatment mainly is: the I type is based on insulin injection, II type and III type are based on Drug therapy, as: sulphanylureas (glibenclamide), biguanides (metformin), the high glucosidase inhibitor acarbose of using of post-prandial glycemia are treated, and also have a kind of thiazolidinediones (gliquidone) that is the intensifier target cell to insulin sensitivity.Western medicine has played fine effect really to blood sugar control, glucose in urine, but these antidiabetic drugs are to no therapeutical effect such as diabetic complications such as coronary heart disease, nephropathy, dermatosis and oculopathy.From traditional Chinese medical science angle: the traditional Chinese medical science diabetes is divided into disappear, disappear, three types of diabetes due to kidney-deficiency, at present, Chinese traditional treatment mainly is: the upper elimination type clearing heat and moistening lung, the promoting the production of body fluid to quench thirst method is as the side of quenching one's thirst; In the type eliminating stomach-fire method that disappears, YIN nourishing and the production of body fluid promoting is as yun; Diabetes due to kidney-deficiency type kidney yin is lost, with the YIN nourishing method of reinforcing the kidney, as LIUWEI DIHUANG WAN; Deficiency of both YIN and YANG is with the warming YANG YIN nourishing method of reinforcing the kidney, as the expensive shenqi pill of gold.The traditional Chinese medical science adopts traditional decoction, tablet, capsule, oral liquid or acupuncture etc., though effectively blood sugar control and glucose in urine, being combined disease also has effect, can treat diabetes, and the dosage of once taking is big, and smell bad is taken inconvenience.The acupuncture pain is strong, increases misery to the patient.Make the patient to treatment by Chinese herbs and acupuncture and moxibustion therapy, toleration is poor, is difficult for accepting, can not adhere to, so, fall flat.
Up to the present, also can not take into account comprehensively, can treat diabetes, can make the patient be easy to accept again, alleviate or avoid the medicine of the misery that the medication treatment brings.
Summary of the invention
In order to address the above problem, the invention provides a kind of taking into account comprehensively, effectively treat Chinese medicine of diabetes and preparation method thereof.
To achieve these goals, the technical solution used in the present invention is: a kind of Chinese medicine for the treatment of diabetes, it is characterized in that comprising following crude drug, and make by weight ratio:
1.0～2.5 parts of Semen Astragali Complanatis, 1.1～2.5 parts of Fructus Trichosanthis, 1.0～2.5 parts of Herba Agrimoniaes,
0.5～1.8 part of Herba Equiseti Hiemalis, 1.0～5.0 parts of the Radixs Astragali, 1.5～6.0 parts of Rhizoma Coptidis,
1.0～2.5 parts of Rhizoma Dioscoreaes, 0.5～4.0 part of Fructus Schisandrae Chinensis, 8.0～12 parts of Herba Portulacaes,
1.0～3.0 parts of Radix Achyranthis, 0.5～2.0 part of Herba azollae imbricatae, 0.3～1.5 part of Radix Salviae Miltiorrhizae,
1.1～2.6 parts of Radix Puerariaes, 0.5～2.0 part of the Radix Paeoniae Alba, 0.5～2.0 part of the Rhizoma Anemarrhenae,
1.0～2.0 parts of 0.1～1.3 part of Gypsum Fibrosum of Radix Polygoni Multiflori, 0.6～2.0 part of Semen Cuscutae,
1.0～2.5 parts of Herba Melicae Scabrosaes, 0.6～2.0 part of Radix Rehmanniae, 1.1～2.5 parts of Ovum Gallus domesticus Flavuss,
1.0～2.5 parts of Caulis Echinopsis Multipliciss, 0.5～1.8 part of Pupa bombycis.
The Chinese medicinal preparation method of above-mentioned treatment diabetes comprises the steps: to get crude drug by above-mentioned weight portion proportioning,
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 8～12 parts of Chinese liquor, and reflux 50～70 minutes after the cooling, was soaked 25～35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 8～12 parts of Chinese liquor, reflux 50～70 minutes, after the cooling, pulping soaked 25～35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, use soaking in Chinese liquor, soaked 3～5 centimetres of powder, soak after 8～12 days, pulping adds 90～110 parts of Chinese liquor, soaks 25～35 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add Chinese liquor to 180～230 part, make principal agent.
According to theory of Chinese medical science, diabetes are divided into three types again: i.e. I type, taste deficiency; The II type, the deficiency of both YIN and YANG type; The III type, type of deficiency of both QI and YIN.Therefore, in order to reach better therapeutic effect, on the basis of above-mentioned principal agent, add medicine by three types.
For the I type, by weight ratio, add following raw material medicaments:
20～25 parts of Rhizoma Atractylodis, 20～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of Colophonium of system, 15～25 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of Herba Schizonepetae;
Wherein, described system Colophonium prepares as follows: get Herba Alii fistulosi and add decocting soup, add Colophonium, boil to Colophonium and melt fully, take advantage of heat to pour in the cold water, take out, dry in the shade; The weight ratio of Colophonium and Herba Alii fistulosi is 8～12: 1.
Preparation method: Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Fagopyri Tatarici and Herba Schizonepetae are placed container, use soaking in Chinese liquor, soaked 3～5 centimetres of powder, soak after 8～12 days, pulping, add system Colophonium,, soaked 25～35 days at 0～16 ℃ with 35～45 parts of immersions of Chinese liquor, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds Chinese liquor to 60～70 part; The medicinal liquid that makes gets final product with the principal agent mix homogeneously of above-mentioned preparation.
For the II type, by weight ratio, add following raw material medicaments:
15～25 parts of Semen Euryaless, 22～32 parts of Rhizoma Polygonati Odorati, 12～22 parts in Poria, 7～17 parts of Fructus Aurantiis, 16～26 parts of the Rhizoma Anemarrhenaes.
For type ii diabetes, the Rhizoma Anemarrhenae umber in the principal agent is few, therefore when preparation type ii diabetes Chinese medicine, on the basis of the Rhizoma Anemarrhenae, adds 16～26 parts the Rhizoma Anemarrhenae again in principal agent.
Preparation method: Semen Euryales, Rhizoma Polygonati Odorati, Poria, Fructus Aurantii and the Rhizoma Anemarrhenae are placed container, use soaking in Chinese liquor, soak 3～5 centimetres of powder, soaked after 8～12 days pulping, add 35～45 parts of immersions of wine, soaked 25～35 days at 0～16 ℃, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds Chinese liquor to 60～70 part; The medicinal liquid that makes gets final product with the principal agent mix homogeneously of above-mentioned preparation.
For the III type, by weight ratio, add following raw material medicaments:
11～21 parts of Ootheca Mantidiss, 16～26 parts of Rhizoma Cyperis, 14～24 parts of Radix Bupleuri, 19～29 parts of Cortex Phellodendris, 13～23 parts of Medulla Juncies.
Preparation method: Ootheca Mantidis, Rhizoma Cyperi, Radix Bupleuri, Cortex Phellodendri and Medulla Junci are placed container, use soaking in Chinese liquor, soak 3～5 centimetres of powder, soaked after 8～12 days pulping, add 35～45 parts of immersions of Chinese liquor, soaked 25～35 days at 0～16 ℃, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds Chinese liquor to 60～70 part; The medicinal liquid that makes gets final product with the principal agent mix homogeneously of above-mentioned preparation.
Used Chinese liquor in the preparation method of the present invention can adopt the Chinese liquor of any number of degrees of buying on the market.
Among the present invention
Semen Astragali Complanati: tonifying the kidney to consolidate the essence, nourishing the liver to improve visual acuity, it is astringent or styptic treatment for spontaneous sweating to belong to temperature compensation, is used for frequent micturition, poor vision.
Fructus Trichosanthis: the function of clearing away heat and promoting production of body fluid is arranged, cure mainly calentura, disappear and drink.
Herba Agrimoniae: nature and flavor are pained flat, go into liver, spleen channel.The arresting sweating of quenching one's thirst.
Herba Equiseti Hiemalis: dispelling wind and heat pathogens, removing nebula to improve visual acuity.
The Radix Astragali: tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance.Can improve immunity, expansion periphery, arteria coronaria and kidney blood vessel, microcirculation improvement.Suppress platelet aggregation, blood pressure lowering is regulated carbohydrate metabolism.
Rhizoma Coptidis: the nature and flavor bitter cold, the fire of the kind stomach that clears away heart-fire has arrhythmia, and blood pressure lowering suppresses platelet aggregation, effect of lowering blood sugar.
Rhizoma Dioscoreae: supplementing QI and nourishing YIN, the tonifying the spleen and stomach kidney is the good merchantable brand of flat QI invigorating the moon, is used for deficiency-heat and quenches one's thirst.
Fructus Schisandrae Chinensis: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, mind tranquilizing and the heart calming.
Herba Portulacae: heat-clearing and toxic substances removing, only quench one's thirst.
Radix Achyranthis: promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing.
Herba azollae imbricatae: only quench one's thirst the dispelling the wind and dampness pathogens stubborn dermatitis.
Radix Salviae Miltiorrhizae: be medicine into the heart, spleen, liver, kidney blood system, blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind.
Radix Puerariae: sweet, hot, spleen, stomach warp are returned in cold, and expelling pathogenic factors from muscles for reducing heat is arranged, and promote the production of body fluid, and are used to quench one's thirst, and the hypertension stiffness of the neck is painful.
The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant, fever due to yin deficiency.
The Rhizoma Anemarrhenae: return through going into lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is moisturized laxation.Control dysphoria with smothery sensation and quench one's thirst, the bath of YIN nourishing profit, promoting the production of body fluid to quench thirst effect are arranged.
Radix Polygoni Multiflori: enrich and benefit essence and blood, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation.Can improve immunity, blood fat reducing.Atherosclerosis, coronary blood flow increasing resists myocardial ischemia.
Gypsum Fibrosum: clearing away heat-fire, relieving restlessness is quenched the thirst.
Semen Cuscutae: the YANG invigorating tonifying YIN, the antidiarrheal that makes eye bright is promoted the production of body fluid.
Herba Melicae Scabrosae: relieve heat and thirst.
Radix Rehmanniae: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.
Ovum Gallus domesticus Flavus: nourshing Yin and drynsessmoistening prescription, nourishing blood for calming endogenous wind.
Caulis Echinopsis Multiplicis: the property slightly sweet flavor is flat.Control the cough due to lung-heat, sputum mixed with blood.
Pupa bombycis: the flat sweet in the mouth of property is nontoxic.Control children's's infantile malnutrition with fever, become thin, quench one's thirst.
Rhizoma Atractylodis: spleen invigorating is arranged, dampness.
The Rhizoma Atractylodis Macrocephalae, air making-up and spleen enlivening, hidroschesis.
Colophonium: dispel the wind, dampness, evacuation of pus is drawn out pus by applying a plaster to the affected part, granulation promoting, pain relieving.
Radix Et Rhizoma Fagopyri Tatarici: treat for stomachache, dyspepsia, dysentery,
Herba Schizonepetae: diffusing wind induces sweat.
Semen Euryales: spleen reinforcing damp eliminating, supplementing the kidney to control the nocturnal.
Rhizoma Polygonati Odorati: nourishing YIN and moistening the lung, the nourishing the stomach of promoting the production of body fluid.
Poria: the sweet light profit of oozing, property is flat not inclined to one side, and holding concurrently can tonify deficiency.
Fructus Aurantii: regulating the flow of QI to ease the stomach, relieving distension by promoting circulation of QI.
Ootheca Mantidis: reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination.
Rhizoma Cyperi: the hot hardship of loosing is fallen, little sweet energy and, property is flat not inclined to one side, is described as the Directorate-General DG of disorder of QI.
Radix Bupleuri: induce sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI.
Cortex Phellodendri: kind fire clearly mutually, reducing the asthenic fever.
Medulla Junci: relieving stranguria by diuresis, relieving restlessness clears away heart-fire.
The present invention also has good curative effect to the complication of diabetes.Merge cardiovascular pathological changes, disease is seen shortness of breath and palpitation, the coronary heart disease performance of twinge uncomfortable in chest, and Radix Salviae Miltiorrhizae and Radix Puerariae have certain curative effect to this.Merge cerebrovascular disease, disease see half body not with, the stiff tongue language is puckery, Radix Rehmanniae, Fructus Aurantii, Radix Achyranthis, Radix Bupleuri, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae have blood circulation promoting and blood stasis dispelling, the effect of collateral dredging has good curative effect to cerebrovascular disease.Merge nephropathy, albuminuria is arranged, hematuria, the limb oliguria that swells, the Radix Astragali, Rhizoma Dioscoreae and Poria have certain effect.Merge scorching itching over the body, the skin symptom that the carbuncle furuncle is given birth to frequently, Rhizoma Coptidis, Cortex Phellodendri, the Radix Paeoniae Alba and Rhizoma Dioscoreae have certain curative effect.Coldness of the body with chills, big loose stool is thin, and Ootheca Mantidis has certain curative effect.
The present invention has nourishing YIN and clearing away heat, invigorates blood circulation, and the function of warming YANG, the energy treating both the principal and secondary aspects of a disease not only has good curative effect to diabetes, and its complication is also had tangible curative effect.
The clinical observation and the controlled trial of [test example] treatment by Chinese herbs diabetes of the present invention.
One, physical data
Experimenter 178 people are divided into matched group and test group
Matched group: 78 people
Test group: 100 people, test group is pressed the type of tcm diagnosis, is divided into three groups
I type 34 people, male 13 people, women 21 people, 30～50 years old age.
II type 31 people, male 19 people, women 12 people, 35～65 years old age.
III type 35 people, male 15 people, women 20 people, 30～55 years old age.
Two, test material:
The contrast medicine: diabetes pill, lot number: LF0014, Guangzhou Zhongyi Medicine Industry Co., Ltd produces.
Investigational agent: the Chinese medicine of the present invention's preparation.
Three, test method:
Matched group: take diabetes pill.
Test group: be divided into I type group by the tcm diagnosis type, II type group, III type group; Take the Chinese medicine of the present invention's preparation.
Four, medication:
Matched group: no matter I type, II type and III type are all taken diabetes pill, one time 8 ball three times on the one, was taken 30 days.
Test group:
The I type: take the Chinese medicine of embodiment 2 preparation, one time 20 milliliters, three times on the one, took 30 days.
The II type: take the Chinese medicine of embodiment 3 preparation, one time 20 milliliters, three times on the one, took 30 days.
The III type: take the Chinese medicine of embodiment 4 preparation, one time 20 milliliters, three times on the one, took 30 days.
Five, diagnostic criteria
I type: taste deficiency, thirsty easy drink, rapid digestion of food and polyorexia, loose stool.
The II type: the deficiency of both YIN and YANG type, frequent micturition, muddy as cream, darkish complexion, the helix parch, the cold physique fear is cold.
The III type: type of deficiency of both QI and YIN, obesity, weak breath is weak, the spontaneous perspiration xerostomia.
Six, efficacy assessment standard
Produce effects: blood sugar urinary sugar recovers normal, and symptom is eliminated.
Take a turn for the better: blood sugar urinary sugar recovers normal, and symptom improves.
Invalid: as not reach the improvement standard.
Seven, therapeutic outcome: see Table 1
Table 1
The result shows that test group has better blood sugar lowering, the glucose in urine effect, and there were significant differences to compare P＜0.01 with matched group.In one month treatment, the result of test group: produce effects 56 examples, 33 examples that take a turn for the better, invalid 12 examples.Obvious effective rate 56%, improvement rate 33%, total effective rate 89%.And diabetes patient's complication has also obviously obtained treatment.And the result of matched group: produce effects 21 examples, 29 examples that take a turn for the better, invalid 28 examples.Total effective rate 64.1%, and diabetes patient's complication does not have obvious therapeutic effect.
Concrete embodiment:
Embodiment 1
A kind of Chinese medicine for the treatment of diabetes, make by following raw material medicaments in part by weight proportioning:
Semen Astragali Complanati 17g, Fructus Trichosanthis 18g, Herba Agrimoniae 17g,
Herba Equiseti Hiemalis 11g, Radix Astragali 30g, Rhizoma Coptidis 38g,
Rhizoma Dioscoreae 17g, Fructus Schisandrae Chinensis 22g, Herba Portulacae 100g,
Radix Achyranthis 20g, Herba azollae imbricatae 12g, Radix Salviae Miltiorrhizae 9g,
Radix Puerariae 18g, Radix Paeoniae Alba 12g, Rhizoma Anemarrhenae 12g,
Radix Polygoni Multiflori 7g, Gypsum Fibrosum 15g, Semen Cuscutae 13g,
Herba Melicae Scabrosae 17g, Radix Rehmanniae 13g, Ovum Gallus domesticus Flavus 18g,
Caulis Echinopsis Multiplicis 17g, Pupa bombycis 11g.
Preparation method is as follows:
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 60 ° of Chinese liquor of 100g, and reflux 60 minutes after the cooling, was soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 60 ° of Chinese liquor of 100g, reflux 60 minutes, after the cooling, pulping soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, with 60 ° of soaking in Chinese liquor, soaked 4 centimetres of powder, soak after 10 days, pulping adds 60 ° of Chinese liquor of 1000g, soaks 30 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add 60 ° of Chinese liquor to 2000g.
Embodiment 2
A kind of Chinese medicine for the treatment of diabetes, make by following raw material medicaments in part by weight proportioning:
Main formula: Semen Astragali Complanati 10g, Fructus Trichosanthis 11g, Herba Agrimoniae 10g,
Herba Equiseti Hiemalis 5g, Radix Astragali 10g, Rhizoma Coptidis 15g,
Rhizoma Dioscoreae 10g, Fructus Schisandrae Chinensis 5g, Herba Portulacae 80g,
Radix Achyranthis 10g, Herba azollae imbricatae 5g, Radix Salviae Miltiorrhizae 3g,
Radix Puerariae 11g, Radix Paeoniae Alba 5g, Rhizoma Anemarrhenae 5g,
Radix Polygoni Multiflori 1g, Gypsum Fibrosum 10g, Semen Cuscutae 6g,
Herba Melicae Scabrosae 10g, Radix Rehmanniae 6g, Ovum Gallus domesticus Flavus 11g,
Caulis Echinopsis Multiplicis 10g, Pupa bombycis 5g.
Secondary prescription: Rhizoma Atractylodis 230g, Rhizoma Atractylodis Macrocephalae 230g, system Colophonium 200g,
Radix Et Rhizoma Fagopyri Tatarici 200g, Herba Schizonepetae 150g;
Make rosiny preparation: get the 100g Herba Alii fistulosi and add 500g decocting soup, add 1000g Colophonium, boil to Colophonium and melt fully, take advantage of heat to pour in the cold water, take out, dry in the shade, standby.
Preparation method is as follows: the weight portion proportioning of pressing main formula earlier, make main liquid,
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 52 ° of Chinese liquor of 80g, and reflux 50 minutes after the cooling, was soaked 25 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 52 ° of Chinese liquor of 80g, reflux 50 minutes, after the cooling, pulping soaked 25 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, with 52 ° of soaking in Chinese liquor, soaked 3 centimetres of powder, soak after 8 days, pulping adds 52 ° of Chinese liquor of 900g, soaks 25 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add 52 ° of Chinese liquor, make main liquid to 1800g.
5) Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Fagopyri Tatarici and Herba Schizonepetae are placed container, with 52 ° of soaking in Chinese liquor, soaked 3 centimetres of powder, soak after 10 days, pulping, add system Colophonium, fully soak, soaked 30 days at 0～16 ℃ with 52 ° of Chinese liquor 400g, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds 52 ° of Chinese liquor to 650g;
6) with the medicinal liquid of the 4th step and the preparation of the 5th step, mix homogeneously gets final product.
The Chinese medicine of present embodiment preparation has the obvious treatment effect to the treatment type i diabetes.
Embodiment 3
A kind of Chinese medicine for the treatment of diabetes, make by following raw material medicaments in part by weight proportioning:
Main formula: Semen Astragali Complanati 20g, Fructus Trichosanthis 20g, Herba Agrimoniae 18g,
Herba Equiseti Hiemalis 10g, Radix Astragali 30g, Rhizoma Coptidis 45g,
Rhizoma Dioscoreae 15g, Fructus Schisandrae Chinensis 23g, Herba Portulacae 100g,
Radix Achyranthis 20g, Herba azollae imbricatae 15g, Radix Salviae Miltiorrhizae 100g,
Radix Puerariae 21g, Radix Paeoniae Alba 15g, Rhizoma Anemarrhenae 150g,
Radix Polygoni Multiflori 8g, Gypsum Fibrosum 15g, Semen Cuscutae 150g,
Herba Melicae Scabrosae 17g, Radix Rehmanniae 15g, Ovum Gallus domesticus Flavus 180g,
Caulis Echinopsis Multiplicis 17g, Pupa bombycis 12g.
Secondary prescription: Semen Euryales 200g, Rhizoma Polygonati Odorati 270g, Poria 170g,
Fructus Aurantii 100g, Rhizoma Anemarrhenae 210g.
Preparation method is as follows: the weight portion proportioning of pressing main formula earlier, make main liquid,
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 38 ° of Chinese liquor of 100g, and reflux 60 minutes after the cooling, was soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 38 ° of Chinese liquor of 100g, reflux 60 minutes, after the cooling, pulping soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, with 38 ° of soaking in Chinese liquor, soaked 4 centimetres of powder, soak after 10 days, pulping adds 1000g Chinese liquor, soaks 30 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add 38 ° of Chinese liquor, make main liquid to 2000g;
5) Semen Euryales, Rhizoma Polygonati Odorati, Poria, Fructus Aurantii and the Rhizoma Anemarrhenae are placed container, soaked 4 centimetres of powder with 38 ° of soaking in Chinese liquor, soak after 10 days, pulping adds wine 400g and fully soaks, and soaks 30 days at 0～16 ℃, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds 38 ° of Chinese liquor to 650g;
6) the 4th step and the 5th is gone on foot the medicinal liquid for preparing, mix homogeneously.
The Chinese medicine of present embodiment preparation has notable therapeutic effect to diabetes type II.
Embodiment 4
A kind of Chinese medicine for the treatment of diabetes, make by following raw material medicaments in part by weight proportioning:
Main formula: Semen Astragali Complanati 25g, Fructus Trichosanthis 25g, Herba Agrimoniae 25g,
Herba Equiseti Hiemalis 18g, Radix Astragali 50g, Rhizoma Coptidis 60g,
Rhizoma Dioscoreae 25g, Fructus Schisandrae Chinensis 40g, Herba Portulacae 120g,
Radix Achyranthis 30g, Herba azollae imbricatae 20g, Radix Salviae Miltiorrhizae 15g,
Radix Puerariae 26g, Radix Paeoniae Alba 20g, Rhizoma Anemarrhenae 20g,
Radix Polygoni Multiflori 13g, Gypsum Fibrosum 20g, Semen Cuscutae 20g,
Herba Melicae Scabrosae 25g, Radix Rehmanniae 20g, Ovum Gallus domesticus Flavus 25g,
Caulis Echinopsis Multiplicis 25g, Pupa bombycis 18g.
Secondary prescription: Ootheca Mantidis 160g, Rhizoma Cyperi 210g, Radix Bupleuri 190g,
Cortex Phellodendri 240g, Medulla Junci 180g.
Preparation method is as follows: the weight portion proportioning of pressing main formula earlier, make main liquid,
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 60 ° of Chinese liquor of 120g, and reflux 70 minutes after the cooling, was soaked 35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 60 ° of Chinese liquor of 120g, reflux 70 minutes, after the cooling, pulping soaked 35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, with 60 ° of soaking in Chinese liquor, soaked 5 centimetres of powder, soak after 12 days, pulping adds 1100g Chinese liquor, soaks 35 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add 60 ° of Chinese liquor, make main liquid to 2300g;
5) Ootheca Mantidis, Rhizoma Cyperi, Radix Bupleuri, Cortex Phellodendri and Medulla Junci are placed container, with 60 ° of soaking in Chinese liquor, soak 5 centimetres of powder, soaked after 12 days pulping, adding 60 ° of Chinese liquor 450g fully soaks, soaked 35 days at 0～16 ℃, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds 60 ° of Chinese liquor to 700g;
6) the 4th step and the 5th is gone on foot the medicinal liquid for preparing, mix homogeneously.
The Chinese medicine of present embodiment preparation has significant curative effect to treatment diabetes III type.
Claims (6)
1. a Chinese medicine for the treatment of diabetes is characterized in that being made up of main formula and secondary prescription,
Described main formula is made by weight ratio by following crude drug:
1.0～2.5 parts of Semen Astragali Complanatis, 1.1～2.5 parts of Fructus Trichosanthis, 1.0～2.5 parts of Herba Agrimoniaes, 0.5～1.8 part of Herba Equiseti Hiemalis, 1.0～5.0 parts of the Radixs Astragali, 1.5～6.0 parts of Rhizoma Coptidis, 1.0～2.5 parts of Rhizoma Dioscoreaes, 0.5～4.0 part of Fructus Schisandrae Chinensis, 8.0～12 parts of Herba Portulacaes, 1.0～3.0 parts of Radix Achyranthis, 0.5～2.0 part of Herba azollae imbricatae, 0.3～1.5 part of Radix Salviae Miltiorrhizae, 1.1～2.6 parts of Radix Puerariaes, 0.5～2.0 part of the Radix Paeoniae Alba, 0.5～2.0 part of the Rhizoma Anemarrhenae, 0.1～1.3 part of Radix Polygoni Multiflori, 1.0～2.0 parts of Gypsum Fibrosum, 0.6～2.0 part of Semen Cuscutae, 1.0～2.5 parts of Herba Melicae Scabrosaes, 0.6～2.0 part of Radix Rehmanniae, 1.1～2.5 parts of Ovum Gallus domesticus Flavuss, 1.0～2.5 parts of Caulis Echinopsis Multipliciss, 0.5～1.8 part of Pupa bombycis;
Described secondary prescription is made by weight ratio by following crude drug:
20～25 parts of Rhizoma Atractylodis, 20～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of Colophonium of system, 15～25 parts of Radix Et Rhizoma Fagopyri Tatarici, 10～20 parts of Herba Schizonepetae;
Wherein, described system Colophonium prepares as follows: get Herba Alii fistulosi and add decocting soup, add Colophonium, boil to Colophonium and melt fully, pour into while hot in the cold water, take out, dry in the shade; The weight ratio of Colophonium and Herba Alii fistulosi is 8～12: 1.
2. a Chinese medicine for the treatment of diabetes is characterized in that being made up of main formula and secondary prescription,
Described main formula is made by weight ratio by following crude drug:
Semen Astragali Complanati 20g, Fructus Trichosanthis 20g, Herba Agrimoniae 18g, Herba Equiseti Hiemalis 10g, Radix Astragali 30g, Rhizoma Coptidis 45g, Rhizoma Dioscoreae 15g, Fructus Schisandrae Chinensis 23g, Herba Portulacae 100g, Radix Achyranthis 20g, Herba azollae imbricatae 15g, Radix Salviae Miltiorrhizae 100g, Radix Puerariae 21g, Radix Paeoniae Alba 15g, Rhizoma Anemarrhenae 150g, Radix Polygoni Multiflori 8g, Gypsum Fibrosum 15g, Semen Cuscutae 150g, Herba Melicae Scabrosae 17g, Radix Rehmanniae 15g, Ovum Gallus domesticus Flavus 180g, Caulis Echinopsis Multiplicis 17g, Pupa bombycis 12g;
Described secondary prescription is made by weight ratio by following crude drug:
Semen Euryales 200g, Rhizoma Polygonati Odorati 270g, Poria 170g, Fructus Aurantii 100g, Rhizoma Anemarrhenae 210g;
Its preparation method is:
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 38 ° of Chinese liquor of 100g, and reflux 60 minutes after the cooling, was soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 38 ° of Chinese liquor of 100g, reflux 60 minutes, after the cooling, pulping soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, with 38 ° of soaking in Chinese liquor, soaked 4 centimetres of powder, soak after 10 days, pulping adds 1000g Chinese liquor, soaks 30 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add 38 ° of Chinese liquor, make main liquid to 2000g;
5) Semen Euryales, Rhizoma Polygonati Odorati, Poria, Fructus Aurantii and the Rhizoma Anemarrhenae are placed container, soaked 4 centimetres of powder with 38 ° of soaking in Chinese liquor, soak after 10 days, pulping adds wine 400g and fully soaks, and soaks 30 days at 0～16 ℃, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds 38 ° of Chinese liquor to 650g;
6) the 4th step and the 5th is gone on foot the medicinal liquid for preparing, mix homogeneously.
3. a Chinese medicine for the treatment of diabetes is characterized in that being made up of main formula and secondary prescription, and described main formula is made by weight ratio by following crude drug:
1.0～2.5 parts of Semen Astragali Complanatis, 1.1～2.5 parts of Fructus Trichosanthis, 1.0～2.5 parts of Herba Agrimoniaes, 0.5～1.8 part of Herba Equiseti Hiemalis, 1.0～5.0 parts of the Radixs Astragali, 1.5～6.0 parts of Rhizoma Coptidis, 1.0～2.5 parts of Rhizoma Dioscoreaes, 0.5～4.0 part of Fructus Schisandrae Chinensis, 8.0～12 parts of Herba Portulacaes, 1.0～3.0 parts of Radix Achyranthis, 0.5～2.0 part of Herba azollae imbricatae, 0.3～1.5 part of Radix Salviae Miltiorrhizae, 1.1～2.6 parts of Radix Puerariaes, 0.5～2.0 part of the Radix Paeoniae Alba, 0.5～2.0 part of the Rhizoma Anemarrhenae, 0.1～1.3 part of Radix Polygoni Multiflori, 1.0～2.0 parts of Gypsum Fibrosum, 0.6～2.0 part of Semen Cuscutae, 1.0～2.5 parts of Herba Melicae Scabrosaes, 0.6～2.0 part of Radix Rehmanniae, 1.1～2.5 parts of Ovum Gallus domesticus Flavuss, 1.0～2.5 parts of Caulis Echinopsis Multipliciss, 0.5～1.8 part of Pupa bombycis;
Described secondary prescription is made by weight ratio by following crude drug:
11～21 parts of Ootheca Mantidiss, 16～26 parts of Rhizoma Cyperis, 14～24 parts of Radix Bupleuri, 19～29 parts of Cortex Phellodendris, 13～23 parts of Medulla Juncies.
4. the preparation method of Chinese medicine of the described treatment diabetes of claim 1 is characterized in that preparation method comprises the steps: the weight portion proportioning of crude drug by claim 1,
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 8～12 parts of Chinese liquor, and reflux 50～70 minutes after the cooling, was soaked 25～35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 8～12 parts of Chinese liquor, reflux 50～70 minutes, after the cooling, pulping soaked 25～35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, use soaking in Chinese liquor, soaked 3～5 centimetres of powder, soak after 8～12 days, pulping adds 90～110 parts of Chinese liquor, soaks 25～35 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add Chinese liquor to 180～230 part;
5) Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Fagopyri Tatarici and Herba Schizonepetae are placed container, use soaking in Chinese liquor, soaked 3～5 centimetres of powder, soak after 8～12 days, pulping, add system Colophonium,, soaked 25～35 days at 0～16 ℃ with 35～45 parts of immersions of Chinese liquor, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds Chinese liquor to 60～70 part;
6) the 4th step and the 5th is gone on foot the medicinal liquid for preparing, mix homogeneously.
5. the preparation method of Chinese medicine of the described treatment diabetes of claim 2 is characterized in that preparation method is as follows: crude drug is by the weight portion proportioning of claim 2,
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 38 ° of Chinese liquor of 100g, and reflux 60 minutes after the cooling, was soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 38 ° of Chinese liquor of 100g, reflux 60 minutes, after the cooling, pulping soaked 30 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, with 38 ° of soaking in Chinese liquor, soaked 4 centimetres of powder, soak after 10 days, pulping adds 1000g Chinese liquor, soaks 30 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add 38 ° of Chinese liquor, make main liquid to 2000g;
5) Semen Euryales, Rhizoma Polygonati Odorati, Poria, Fructus Aurantii and the Rhizoma Anemarrhenae are placed container, soaked 4 centimetres of powder with 38 ° of soaking in Chinese liquor, soak after 10 days, pulping adds wine 400g and fully soaks, and soaks 30 days at 0～16 ℃, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds 38 ° of Chinese liquor to 650g;
6) the 4th step and the 5th is gone on foot the medicinal liquid for preparing, mix homogeneously.
6. the preparation method of Chinese medicine of the described treatment diabetes of claim 3 is characterized in that preparation method comprises the steps: the weight portion proportioning of crude drug by claim 3,
1) get Pupa bombycis and pulverize, cross 40 mesh sieves, Ovum Gallus domesticus Flavus pulverizes, and two medicine mixings add 8～12 parts of Chinese liquor, and reflux 50～70 minutes after the cooling, was soaked 25～35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid A;
2) get the Rhizoma Coptidis and the Radix Astragali and add 8～12 parts of Chinese liquor, reflux 50～70 minutes, after the cooling, pulping soaked 25～35 days at 0～16 ℃, got supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, makes medical liquid B;
3) get all the other medicines, use soaking in Chinese liquor, soaked 3～5 centimetres of powder, soak after 8～12 days, pulping adds 90～110 parts of Chinese liquor, soaks 25～35 days at 0～16 ℃, gets supernatant, the medicinal residues press filtration, and filtrate is mixed with supernatant, makes medicinal liquid C;
4) A liquid, B liquid and C liquid are mixed, add Chinese liquor to 180～230 part;
5) Ootheca Mantidis, Rhizoma Cyperi, Radix Bupleuri, Cortex Phellodendri and Medulla Junci are placed container, use soaking in Chinese liquor, soak 3～5 centimetres of powder, soaked after 8～12 days pulping, add 35～45 parts of immersions of Chinese liquor, soaked 25～35 days at 0～16 ℃, get supernatant, the medicinal residues press filtration, filtrate is mixed with supernatant, adds Chinese liquor to 60～70 part;
6) the 4th step and the 5th is gone on foot the medicinal liquid for preparing, mix homogeneously.
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| WO2018201579A1 (en) * | 2017-04-30 | 2018-11-08 | 朱秀青 | Medicated chicken |
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