CN100540041C - A kind of promoting intelligence and strengthening brain preparation and preparation method thereof - Google Patents
A kind of promoting intelligence and strengthening brain preparation and preparation method thereof Download PDFInfo
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- CN100540041C CN100540041C CNB2006100224510A CN200610022451A CN100540041C CN 100540041 C CN100540041 C CN 100540041C CN B2006100224510 A CNB2006100224510 A CN B2006100224510A CN 200610022451 A CN200610022451 A CN 200610022451A CN 100540041 C CN100540041 C CN 100540041C
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Abstract
A kind of promoting intelligence and strengthening brain preparation and preparation method thereof belongs to pharmaceutical composition, in particular for the pharmaceutical composition of health product aspect, and its preparation method.It mainly comprises the raw material of following weight portion: Ganoderma 100-300, Radix Rhodiolae 100-300, Radix Polygoni Multiflori Preparata 100-300, Fructus Alpiniae Oxyphyllae 50-150, Radix Panacis Quinquefolii 50-150.These raw materials are made capsule, drop pill, tablet or granule etc.Its advantage is that scientific formulation is reasonable, promoting intelligence and strengthening brain, and it is respond well to improve body immunity.
Description
(1) technical field:
A kind of promoting intelligence and strengthening brain preparation and preparation method thereof belongs to pharmaceutical composition, in particular for the pharmaceutical composition of health product aspect, and its preparation method.
(2) background technology:
Various on the market at present health product are a lot, but the health product of pure Chinese medicinal preparation are very limited, in particular for the health product of promoting intelligence and strengthening brain, raising body immunity, because its prescription is not quite reasonable, so usually can not receive ideal effect.
(3) summary of the invention:
The problem to be solved in the present invention provides a kind of prescription reasonable, respond well at above deficiency exactly, is used for the pure Chinese medicinal preparation Halth-care composition of promoting intelligence and strengthening brain, raising body immunity, and its preparation method.Its technical scheme is as follows:
Said composition mainly comprises the raw material of following weight portion:
Ganoderma 100-300 Radix Rhodiolae 100-300 Radix Polygoni Multiflori Preparata 100-300 Fructus Alpiniae Oxyphyllae 50-150 Radix Panacis Quinquefolii 50--150.
In order to reach better effect, medicine material of the present invention also comprises Fructus Hippophae 100--300, Fructus Phyllanthi 50--250, Radix Puerariae 50--250.
In order to obtain optimum efficiency, medicine material of the present invention further comprises Poria 50-250, Fructus Lycii 50-250, Fructus Jujubae 50-150, Rhizoma Zingiberis 20--100.
The preparation method of product of the present invention is:
(1) will except that each medicine Radix Panacis Quinquefolii, 50% Radix Rhodiolae with water extraction 2--3 time: add a raw material 6--10 times water gaging for the first time and boil and extracted 1.5--3 hour, collect extracting solution; For the second time or add a raw material 6--10 times water gaging for the third time and boil and extracted 1-2 hour, collect extracting solution; Merge extracted twice liquid, filter, concentrate dry extract.
(2) with Radix Panacis Quinquefolii, 50% Radix Rhodiolae drying, crushing screening, standby.
(3) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, sterilization.
(4) material pelletization, the drying after sterilization incapsulates, or makes drop pill, or be pressed into tablet, or make granule.
Compared with prior art the invention has the beneficial effects as follows: scientific formulation is reasonable, and promoting intelligence and strengthening brain, to improve body immunity respond well.
Can promoting intelligence and strengthening brain thereby the present invention makes with each drug regimen that each efficacy of drugs produces synergism, improve body immunity.Ganoderma: lightly seasoned, warm in nature.Function is nourished strong.Modern pharmacological research shows to have anti-hypoxia, enhancing immunity, anti-aging effects.Fructus Hippophae: hide name " Da Erbu ", sour in the mouth, little sweet, property is flat.The function eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.Pharmacological evaluation proves that Fructus Hippophae total flavones has the arteria coronaria of increasing and myocardial nutritional flow amount, reduces effects such as myocardium keto consumption and anticoagulant.According to the study, Fructus Hippophae is kept fit and defying age, anti-hypoxia, enhancing immunity effect.Radix Rhodiolae: hide name " Suo Luomabao ", sweet in the mouth, little hardship, cool in nature.Function boosting qi and nourishing yin, heart tonifying Fructus Alpiniae Oxyphyllae.Modern pharmacological research shows that Radix Rhodiolae has resisting fatigue, anti-hypoxia, enhancing immune function of human body, adapts to the former state effect.Radix Panacis Quinquefolii: sweet in the mouth, little hardship, cool in nature.Function lung benefiting the moon, clear asthenic fire, promoting the production of body fluid to quench thirst.Modern pharmacological research shows to have anti-hypoxia, resisting fatigue, enhancing immunity effect.Radix Polygoni Multiflori Preparata: bitter in the mouth, sweet, puckery, temperature.The function invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.Modern pharmacological research shows to have slow down aging, enhancing immunity effect.Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature.Function is warming spleen and stopping diarrha takes the photograph saliva, warming the kidney controlling nocturnal emission with astringent drugs reducing urination.Poria: sweet in the mouth, light, property is flat.The function promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Modern pharmacological research shows to have the enhancing immunity effect.Fructus Phyllanthi: sweet in the mouth, acid, puckery, cool in nature.The function clearing away heat and cooling blood, promoting digestion and invigorating the stomach, the cough-relieving of promoting the production of body fluid.Fructus Lycii: sweet in the mouth, property is flat.Function tonification Liver and kidney, replenishing vital essence to improve eyesight.Modern pharmacological research shows to have the enhancing immunity effect.Radix Puerariae: sweet in the mouth, suffering, property is flat.Function expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Modern pharmacological research shows to have the enhancing immunity effect.Simultaneously, have the oxygen consumption that reduces cardiac muscle, dilating coronary blood vessel, coronary blood flow increasing increases the supply effect of oxygen.Fructus Jujubae: sweet in the mouth, warm in nature.Function invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Modern pharmacological research shows to have enhancing immunity, anti-aging effects.Rhizoma Zingiberis: acrid in the mouth, hot in nature.Function warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, the dampness expectorant.Modern pharmacological research shows to have oxygen lack resistant function.
For showing the effect of medicine of the present invention to promoting intelligence and strengthening brain, raising body immunity, the present invention has done the clinical observation of system to 88 routine hypoimmunity patients:
Experimenter group: be diagnosed as the patient of hypoimmunity through disease, the age is between 18-65 year, serious primary disease such as no cardiovascular, liver, kidney and psychosis.
Dosage regimen: oral dosage form of the present invention, be equivalent to crude drug amount 5.7g-8g at every turn, every day 1 time, each 3, the consumption per day of being grown up is equivalent to 1/50th of safe dose.
The course of treatment: 30-90 days.
The produce effects standard: the spiritlessness and weakness sense is eliminated, and energetic have a vigor, and appetite strengthens, the study and work improved efficiency; Full of vitality, clearheaded, sleep soundly, remember that body constitution obviously strengthens, study and work has passion; Thought active, energetic, happy, can bring into play intellectual potential when participating in the cintest, memory significantly strengthens.
Effective standard: the spiritlessness and weakness sense is eliminated, and energetic have a vigor, and appetite strengthens, the study and work improved efficiency; Full of vitality, clearheaded, sleep soundly, remember that body constitution strengthens; Thought active, happy.
Through the total obvious effective rate of rough estimates is 90.9%, and effective percentage is 85.2%.Do not find that in the outpatient service process of clinical application this medicine has obvious adverse reaction, takes safety.
Below be to utilize mice to test, verify the effect of product promoting intelligence and strengthening brain of the present invention with this:
Mice is divided into matched group and administration group by body weight, 20 every group.Administration group mice by every day per kilogram of body weight give product crude drug 0.05g of the present invention; Not administration of control group mice continuous 30 days, is adopted the step down test method respectively, is kept away dark test method(s) and test last day.The result shows: product of the present invention has the effect of hypermnesis to mice.
(4) description of drawings
Accompanying drawing is a process chart of the present invention.
(5) specific embodiment:
Embodiment one:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 100 Radix Rhodiolaes 100 Radix Polygoni Multiflori Preparatas 100 Fructus Alpiniae Oxyphyllae 50 Radix Panacis Quinquefoliis 50
Its preparation method may further comprise the steps:
(1) Radix Panacis Quinquefolii, 50 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(2) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(3) with Ganoderma, 50 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii with water extraction 2 times: add 8 times of water gagings of raw material for the first time and boil and extracted 2 hours, collect extracting solution; Add for the second time 7 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are that 0.04Mpa, temperature are that to be concentrated into relative density under 65 ℃ of conditions be 1.13-1.17 (50 ℃ of intermittent fever are surveyed) at vacuum pressure, with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 65% ethanol wet granulation, and 20 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 40 parts of magnesium stearate, use the mixer mixing, incapsulate.
Embodiment two:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 300 Radix Rhodiolaes 300 Radix Polygoni Multiflori Preparatas 300 Fructus Alpiniae Oxyphyllae 150 Radix Panacis Quinquefoliis 150
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(2) Radix Panacis Quinquefolii, 150 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(3) with Ganoderma, 150 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii with water extraction 3 times: add 10 times of water gagings of raw material for the first time and boil and extracted 3 hours, collect extracting solution; Add 10 times of water gagings of raw material for the second time and for the third time and boil extraction 2 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.06MPa at vacuum pressure, temperature is that to be concentrated into relative density under 75 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 75% ethanol wet granulation, and 24 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 100 parts of dextrin, use the mixer mixing, be pressed into tablet.
Embodiment three:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 200 Radix Rhodiolaes 200 Radix Polygoni Multiflori Preparatas 200 Fructus Alpiniae Oxyphyllae 100 Radix Panacis Quinquefoliis 100
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(2) with Ganoderma, 100 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii with water extraction 2 times: add 8 times of water gagings of raw material for the first time and boil and extracted 2 hours, collect extracting solution; Add for the second time 7 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.05MPa at vacuum pressure, temperature is that to be concentrated into relative density under 70 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(3) Radix Panacis Quinquefolii, 100 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 70% ethanol wet granulation, and 18 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 80 parts of steviosin, use the mixer mixing, make granule.
Embodiment four:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 100 Radix Rhodiolaes 100 Radix Polygoni Multiflori Preparatas 100 Fructus Alpiniae Oxyphyllae 50 Radix Panacis Quinquefoliis 50 Fructus Hippophaes 100
Fructus Phyllanthi 50 Radix Puerariaes 50
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(2) with Ganoderma, 50 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae with water extraction 2 times: add 6 times of water gagings of raw material for the first time and boil and extracted 1.5 hours, collect extracting solution; Add for the second time 6 times of water gagings of raw material and boil extraction 1 hour, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.04MPa at vacuum pressure, temperature is that to be concentrated into relative density under 65 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(3) Radix Panacis Quinquefolii, 50 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 65% ethanol wet granulation, and 18 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 60 parts of dextrin, use the mixer mixing, incapsulate.
Embodiment five:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 300 Radix Rhodiolaes 300 Radix Polygoni Multiflori Preparatas 300 Fructus Alpiniae Oxyphyllae 150 Radix Panacis Quinquefoliis 150
Fructus Hippophae 300 Fructus Phyllanthis 250 Radix Puerariaes 250
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(2) Radix Panacis Quinquefolii, 150 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(3) with Ganoderma, 150 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae with water extraction 3 times: add 10 times of water gagings of raw material for the first time and boil and extracted 3 hours, collect extracting solution; Add 10 times of water gagings of raw material for the second time and for the third time and boil extraction 2 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.06MPa at vacuum pressure, temperature is that to be concentrated into relative density under 75 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 75% ethanol wet granulation, and 24 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 200 parts of starch, use the mixer mixing, be pressed into tablet.
Embodiment six:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 200 Radix Rhodiolaes 200 Radix Polygoni Multiflori Preparatas 200 Fructus Alpiniae Oxyphyllae 100 Radix Panacis Quinquefoliis 100
Fructus Hippophae 200 Fructus Phyllanthis 150 Radix Puerariaes 150
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(2) with Ganoderma, 100 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae with water extraction 2 times: add 8 times of water gagings of raw material for the first time and boil and extracted 2 hours, collect extracting solution; Add for the second time 7 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.05MPa at vacuum pressure, temperature is that to be concentrated into relative density under 70 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(3) Radix Panacis Quinquefolii, 100 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) Macrogol 4000 and polyethylene glycol 6000 are mixed, under 65 ℃～85 ℃ constant temperatures, dissolve, add the material after sterilization, mixture is splashed in the methyl-silicone oil coolant make drop pill.Macrogol 4000 is 80 parts, and polyethylene glycol 6000 is 50 parts.
Embodiment seven:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 100 Radix Rhodiolaes 100 Radix Polygoni Multiflori Preparatas 100 Fructus Alpiniae Oxyphyllae 50 Radix Panacis Quinquefoliis 50 Fructus Hippophaes 100
Fructus Phyllanthi 50 Radix Puerariaes 50 Poria 50 Fructus Lycii 50 Fructus Jujubaes 50 Rhizoma Zingiberiss 20
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces; Rhizoma Zingiberis is bubble slightly, cleans, and runs through, and cuts sheet or piece, drying;
(2) Radix Panacis Quinquefolii, 50 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(3) with Ganoderma, 50 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae, Poria, Fructus Lycii, Fructus Jujubae, Rhizoma Zingiberis with water extraction 2 times: add 6 times of water gagings of raw material for the first time and boil and extracted 1.5 hours, collect extracting solution; Add for the second time 6 times of water gagings of raw material and boil extraction 1 hour, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are that 0.04Mpa, temperature are that to be concentrated into relative density under 65 ℃ of conditions be 1.13-1.17 (50 ℃ of intermittent fever are surveyed) at vacuum pressure, with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 65% ethanol wet granulation, and 18 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 80 parts of calcium carbonate, use the mixer mixing, incapsulate.
Embodiment eight:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 300 Radix Rhodiolaes 300 Radix Polygoni Multiflori Preparatas 300 Fructus Alpiniae Oxyphyllae 150 Radix Panacis Quinquefoliis 150 Fructus Hippophaes 300
Fructus Phyllanthi 250 Radix Puerariaes 250 Poria 250 Fructus Lycii 250 Fructus Jujubaes 150 Rhizoma Zingiberiss 100
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces; Rhizoma Zingiberis is bubble slightly, cleans, and runs through, and cuts sheet or piece, drying;
(2) with Ganoderma, 150 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae, Poria, Fructus Lycii, Fructus Jujubae, Rhizoma Zingiberis with water extraction 3 times: add 10 times of water gagings of raw material for the first time and boil and extracted 3 hours, collect extracting solution; Add 10 times of water gagings of raw material for the second time and for the third time and boil extraction 2 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.06MPa at vacuum pressure, temperature is that to be concentrated into relative density under 75 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(3) Radix Panacis Quinquefolii, 150 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 75% ethanol wet granulation, and 24 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 250 parts of carboxymethyl starch sodium, use the mixer mixing, be pressed into tablet.
Embodiment nine:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 200 Radix Rhodiolaes 200 Radix Polygoni Multiflori Preparatas 200 Fructus Alpiniae Oxyphyllae 100 Radix Panacis Quinquefoliis 100 Fructus Hippophaes 200
Fructus Phyllanthi 150 Radix Puerariaes 150 Poria 150 Fructus Lycii 150 Fructus Jujubaes 100 Rhizoma Zingiberiss 60
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces; Rhizoma Zingiberis is bubble slightly, cleans, and runs through, and cuts sheet or piece, drying;
(2) with Ganoderma, 100 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae, Poria, Fructus Lycii, Fructus Jujubae, Rhizoma Zingiberis with water extraction 2 times: add 8 times of water gagings of raw material for the first time and boil and extracted 2 hours, collect extracting solution; Add for the second time 7 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.05MPa at vacuum pressure, temperature is that to be concentrated into relative density under 70 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(3) Radix Panacis Quinquefolii, 100 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
(5) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 70% ethanol wet granulation, and 20 orders sieve, granulate, under 60-80 ℃ of condition, be dried to moisture with drying equipment and be not more than 8.0%, add 180 parts of aspartames, use the mixer mixing, make granule.
Embodiment ten:
Present embodiment mainly comprises the raw material of following weight portion:
Ganoderma 200 Radix Rhodiolaes 200 Radix Polygoni Multiflori Preparatas 200 Fructus Alpiniae Oxyphyllae 100 Radix Panacis Quinquefoliis 100 Fructus Hippophaes 200
Fructus Phyllanthi 150 Radix Puerariaes 150 Poria 150 Fructus Lycii 150 Fructus Jujubaes 100 Rhizoma Zingiberiss 60
Its preparation method may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces; Rhizoma Zingiberis is bubble slightly, cleans, and runs through, and cuts sheet or piece, drying;
(2) with Ganoderma, 100 parts of Radix Rhodiolaes, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Radix Panacis Quinquefolii, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae, Poria, Fructus Lycii, Fructus Jujubae, Rhizoma Zingiberis with water extraction 2 times: add 8 times of water gagings of raw material for the first time and boil and extracted 2 hours, collect extracting solution; Add for the second time 7 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 100 orders filter, and are 0.05MPa at vacuum pressure, temperature is that to be concentrated into relative density under 70 ℃ of conditions be 1.13-1.17 (50 ℃ intermittent fever survey), with spray dryer spray drying extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
(3) Radix Panacis Quinquefolii, 100 parts of Radix Rhodiolaes is clean with the medical material surface clean with drinking water, 60-80 ℃ be dried to moisture content less than 7.0%, pulverized 100 mesh sieves, standby.
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, be that 115 ℃, air pressure are under the 0.068MPa condition in temperature, sterilized 30 minutes.
4) material after sterilization is in harmonious proportion with 30 parts of salad oils, uses the vibrating ball-mill mixing, incapsulates in the spice bucket of machine standby;
5) get gelatin: glycerol: water: red ferric oxide=100: 40: 100: 2.0, make sizing material in the inputization glue jar, incapsulate in the sizing material bucket of machine standby;
6) sizing material bucket and spice bucket are delivered to capsule machine top making soft capsule.
Above dosage form capsule, soft capsule, drop pill, tablet or particulate preparation method are conventional method.
Claims (8)
1, a kind of promoting intelligence and strengthening brain preparation is characterized in that it mainly comprises the raw material of following weight portion: Ganoderma 100-300, Radix Rhodiolae 100-300, Radix Polygoni Multiflori Preparata 100-300, Fructus Alpiniae Oxyphyllae 50-150, Radix Panacis Quinquefolii 50-150.
2, promoting intelligence and strengthening brain preparation according to claim 1 is characterized in that wherein raw material also has Fructus Hippophae 100--300, Fructus Phyllanthi 50--250, Radix Puerariae 50--250.
3, promoting intelligence and strengthening brain preparation according to claim 2 is characterized in that wherein raw material also has Poria 50-250, Fructus Lycii 50-250, Fructus Jujubae 50-150, Rhizoma Zingiberis 20-100.
4,, it is characterized in that said preparation is any peroral dosage form according to claim 1 or 2 or 3 described promoting intelligence and strengthening brain preparations.
5, promoting intelligence and strengthening brain preparation according to claim 4 is characterized in that said preparation is capsule, drop pill, tablet or granule.
6, the preparation method of the described promoting intelligence and strengthening brain preparation of claim 1 is characterized in that may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(2) with Ganoderma, 50% Radix Rhodiolae, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae with water extraction 2 times: add a raw material 6--10 times water gaging for the first time and boil and extracted 1.5--3 hour, collect extracting solution; Add for the second time a raw material 6--10 times water gaging and boil extraction 1-2 hour, collect extracting solution; Merge extracted twice liquid, filter, concentrate dry extract.
(3) with Radix Panacis Quinquefolii, 50% Radix Rhodiolae drying, crushing screening, standby;
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, sterilization;
(5) material pelletization, the drying after sterilization incapsulates, or makes drop pill, or be pressed into tablet, or make granule.
7, the preparation method of the described promoting intelligence and strengthening brain preparation of claim 2 is characterized in that may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces;
(2) with Ganoderma, 50% Radix Rhodiolae, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae with water extraction 2 times: add a raw material 6--10 times water gaging for the first time and boil and extracted 1.5--3 hour, collect extracting solution; Add for the second time a raw material 6--10 times water gaging and boil extraction 1-2 hour, collect extracting solution; Merge extracted twice liquid, filter, concentrate dry extract;
(3) with Radix Panacis Quinquefolii, 50% Radix Rhodiolae drying, crushing screening, standby;
(4) with extract fine powder and Radix Panacis Quinquefolii and 50% Radix Rhodiolae fine powder mix homogeneously, sterilization;
(5) material pelletization, the drying after sterilization incapsulates, or makes drop pill, or be pressed into tablet, or make granule.
8, the preparation method of promoting intelligence and strengthening brain preparation according to claim 3 is characterized in that may further comprise the steps:
(1) Radix Rhodiolae is removed fibrous root, section; Fructus Alpiniae Oxyphyllae is smashed to pieces; Rhizoma Zingiberis is bubble slightly, cleans, and runs through, and cuts sheet or piece, drying;
(2) with Ganoderma, 50% Radix Rhodiolae, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Fructus Hippophae, Fructus Phyllanthi, Radix Puerariae, Poria, Fructus Lycii, Fructus Jujubae, Rhizoma Zingiberis with water extraction 2 times: add a raw material 6--10 times water gaging for the first time and boil and extracted 1.5--3 hour, collect extracting solution; Add for the second time a raw material 6--10 times water gaging and boil extraction 1-2 hour, collect extracting solution; Merge extracted twice liquid, filter, concentrate dry extract;
(3) with Radix Panacis Quinquefolii, 50% Radix Rhodiolae drying, crushing screening, standby;
(4) with extract fine powder and Radix Panacis Quinquefolii and Radix Rhodiolae fine powder mix homogeneously, sterilization;
(5) material pelletization, the drying after sterilization incapsulates, or makes drop pill, or be pressed into tablet, or make granule.
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| CN103505518A (en) * | 2012-06-28 | 2014-01-15 | 天津天狮生物发展有限公司 | Blood lipid reducing composition containing kudzuvine root and preparation method of composition |
| CN102949527A (en) * | 2012-11-23 | 2013-03-06 | 周纯喜 | Traditional Chinese medicinal preparation for treating senile dementia and corresponding preparation method |
| CN103445156A (en) * | 2013-07-31 | 2013-12-18 | 宫中林 | Compound brain oral liquid of rhodiola rosea and walnut |
| CN103609791B (en) * | 2013-10-31 | 2015-01-28 | 安徽博格生物科技有限公司 | Tea bag capable of increasing brain function and improving memory |
| CN104069262A (en) * | 2014-07-17 | 2014-10-01 | 江苏东博生物医药有限公司 | Composition for improving immunity, and preparation method and application |
| CN104095238A (en) * | 2014-08-11 | 2014-10-15 | 溧阳市天目湖保健品有限公司 | Health food capable of improving immune adjustment capacity and preparation method thereof |
| CN106362065A (en) * | 2016-10-21 | 2017-02-01 | 代立新 | Traditional Chinese medicine with effects of improving intelligence and strengthening brains and method for preparing traditional Chinese medicine |
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