CN1969975B - Formulation for replenishing qi, regenerating blood, tonigying kidney and nourishing face and method for preparing same - Google Patents
Formulation for replenishing qi, regenerating blood, tonigying kidney and nourishing face and method for preparing same Download PDFInfo
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- CN1969975B CN1969975B CN2006100224506A CN200610022450A CN1969975B CN 1969975 B CN1969975 B CN 1969975B CN 2006100224506 A CN2006100224506 A CN 2006100224506A CN 200610022450 A CN200610022450 A CN 200610022450A CN 1969975 B CN1969975 B CN 1969975B
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Abstract
The invention relates to a process for preparing medicament for kidney-nourishing, wherein the raw materials include (by weight portions) ginseng fruit 4-12, donkey-hide gelatin 1-5, red deer placenta 2-10, kudzuvine root 5-15, raspberry 2-10, the medicament can be in the forms of capsules, dripping pills, tablets and granules.
Description
(1) technical field:
A kind of QI invigorating and blood producing, the kidney invigorating care preparation and preparation method thereof belong to pharmaceutical composition, in particular for the pharmaceutical composition of health product aspect, and its preparation method.
(2) background technology:
Various on the market at present health product are a lot, but the health product of pure Chinese medicinal preparation are very limited, in particular for the health product of QI invigorating and blood producing, the kidney invigorating skin care, because its prescription is not quite reasonable, so usually can not receive ideal effect.
(3) summary of the invention:
The problem to be solved in the present invention is exactly to provide a kind of pure Chinese medicinal preparation Halth-care composition of filling a prescription reasonable, respond well at above deficiency, and its preparation method.Its technical scheme is as follows:
Said composition mainly comprises the raw material of following weight portion: Herba Herminii 4-12 Colla Corii Asini 1-5 Embryo cervi 2-10 Radix Puerariae 5-15 Fructus Rubi 2-10.
In order to reach better effect, medicine material of the present invention also comprises Semen Ziziphi Spinosae 5-15, Semen Cassiae 2-10.
In order to obtain optimum efficiency, medicine material of the present invention further comprises Herba Epimedii 10-20, Fructus Lycii 5-20, soybean extract 1-5, Rhizoma Polygonati 2-10, Poria 5-15, Radix Paeoniae Alba 2-12, Fructus Gardeniae 2-10.
The preparation method of product of the present invention is:
1) above-mentioned each botanical herbs is extracted twice: add 6～10 times of amounts of raw material, 40% ethanol for the first time and boil back to heat up in a steamer and extracted 1.5～3 hours, extracting solution recovery ethanol filters stand-by; Add for the second time 6～10 times of water gagings of raw material and boil extraction 1～2 hour, collect extracting solution; Merge extracted twice liquid, filter, be concentrated into relative density 1.12～1.18, dry extract.
2) Colla Corii Asini and Embryo cervi pulverize separately are sieved;
3) will sterilize behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) material pelletization after sterilization, drying is sieved, and mixing incapsulates, or makes drop pill, or is pressed into tablet, or makes granule.
Compared with prior art the invention has the beneficial effects as follows: scientific formulation is reasonable, and QI invigorating, skin care are respond well.
Can QI invigorating and blood producing thereby the present invention makes with each drug regimen that each efficacy of drugs produces synergism, the kidney invigorating skin care.Herba Herminii: sweet in the mouth, hardship, property is flat.Function tonifying QI to produce body fluid, the Fructus Alpiniae Oxyphyllae of reposing, defying age.Modern pharmacological research shows to have immunomodulating, antifatigue effect.Colla Corii Asini: sweet in the mouth, property is flat.Function enrich blood yin nourishing, moisturize hemostasis, antiabortive.Modern pharmacological research shows to have enhancing immunity and antifatigue effect.Embryo cervi: sweet in the mouth, salty, warm in nature.The function kidney-reinforcing Yang-strengthening, tonify deficiency promotes the production of body fluid.Herba Epimedii: sweet in the mouth, warm in nature.Function reinforcing the kidney and supporting YANG, strengthening the tendons and bones.Modern pharmacological research shows to have enhancing immunity and antifatigue effect.Fructus Lycii: sweet in the mouth, property is flat.Function the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.Modern pharmacological research shows to have the enhance immunity effect.Soybean extract: have effects such as enhancing immunity, antioxidation.Radix Puerariae: sweet in the mouth, suffering, property is flat.Function expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Modern pharmacological research shows to have the enhance immunity effect.Semen Ziziphi Spinosae: sweet in the mouth, property is flat.Function mind tranquilizing and the heart calming, nourishing the liver arresting sweating.Modern pharmacological research shows that Semen Ziziphi Spinosae has the enhance immunity effect.Fructus Rubi: sweet in the mouth, acid, property is flat.The function liver and kidney tonifying, controlling nocturnal emission with astringent drugs place urine.Rhizoma Polygonati: sweet in the mouth, property is flat.The function nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI, nourishing kidney replenishing essence.Modern pharmacological research shows to have the enhance immunity effect.Semen Cassiae: bitter in the mouth, sweet, salty, cool in nature.Function liver heat removing and eyesight improving, loosening bowel to relieve constipation.Poria: sweet in the mouth, light, property is flat.Function promoting diuresis to eliminate damp pathogen, spleen invigorating and in, mind tranquilizing and the heart calming.Modern pharmacological research shows to have the enhance immunity effect.The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature.Function nourishes blood and battalion, relieving spasm to stop pain, yin fluid astringing easing the affected liver.Modern pharmacological research shows to have the enhance immunity effect.Fructus Gardeniae: bitter in the mouth, cold in nature.Function pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.
Herba Herminii saponin's defying age effect 327 examples show that dizzy, tired, uncomfortable in chest, insomnia are had significant curative effect (P＜0.05～0.01).Colla Corii Asini and Colla Corii Asini electuary be effects such as resisting fatigue, anoxia enduring, brain-strengthening, slow down aging obviously.Herba Epimedii FEBM can strengthen sedative-hypnotic effect and the prolongation mice swimming time of mice to pentobarbital sodium, has obvious antifatigue effect; Give mouse stomach Herba Epimedii total flavones 0.06 or 0.3g/kg/ days, continuous 11 days, experiment in 1 hour after the last administration. the matched group swimming time is 152.6 ± 45.5 seconds as a result, the administration group was respectively 370.5 ± 108.2 and 398.0 ± 109.1 seconds, with matched group highly significant difference (P＜0.01) is arranged more all, illustrate that Herba Epimedii can prolong the mice swimming time, has obvious antifatigue effect.
Colla Corii Asini has the human body immunity improving function.Colla Corii Asini can improve special Flos Rosae Rugosae rate of body and mononuclear phagocyte function; Can resist the cellular immunization inhibitory action due to the hydrocortisone; The NK cell there is facilitation, illustrates that Colla Corii Asini has the body cell of raising immunologic function.
Herba Epimedii total flavones can obviously improve mice serum hemolytic antibody level, increases spleen antibody-producting cell number, promotes the lymphocyte transfer reaction that PHA stimulates, and strengthens phagocytosis of macrophages.Epimedium brevicornum polysaccharide can increase " immunological memory " function simultaneously to the effect of the humoral immunization of promotion is arranged during humoral immune reaction for the first time once more.
Fructus Lycii, fruit stem, leaf and lycium barbarum polysaccharide all can significantly improve phagocyte phagocytic percentage and phagocytic index, and Fructus Lycii, fruit stem and lycium barbarum polysaccharide can significantly improve the serum lysozyme vigor; Fructus Lycii all has facilitation to humoral immunization and cellular immunization.
Radix Puerariae has immunoregulation effect.
Semen Ziziphi Spinosae polysaccharide oral 0.1g/kg. every day is total to administration 16 days, can strengthen humoral immune function and the cellular immune function of mice.
Rhizoma Polygonati energy human body immunity improving function has the effect that strengthens cellular immune function.Pachyman can make the caused by cyclophosphamide rat leukocyte reduce and quicken, and improves macrophage to single celled phagocytic function.The methylol pachyman can obviously strengthen the generation of mice spleen T cell growth factor.
Radix Paeoniae Alba water decoction has obvious facilitation to macrophage function; But Radix Paeoniae Alba decocting liquid antagonism cyclophosphamide makes it to recover normal level to the inhibitory action of mice periphery blood T lymphocyte, shows that the Radix Paeoniae Alba can make the cellular immune function that is in low state recover normal; Record the sheep red blood cell OD value of mouse boosting cell mediation with quantitative haemolysis spectrophotography, the result sees, Radix Paeoniae Alba decocting group illustrates that than the obvious raising of matched group the Radix Paeoniae Alba can promote splenocyte antibody to generate, and strengthens the humoral response of mice to sheep red blood cell (SRBC) specifically.
For showing the effect of medicine of the present invention to human body QI invigorating, skin care, the present invention to the 112 routine deficiency of vital energys, deficiency of vital energy and physically weak, spiritlessness and weakness, skin coarse unglazed, skin wrinkle and mottle, ache all over, clinical observation that the breast development person who suffers influences has made system:
Experimenter group: through disease be diagnosed as deficiency of vital energy and physically weak, spiritlessness and weakness, skin coarse unglazed, skin wrinkle and mottle, ache all over, the affected patient of breast development, age is between 18-65 year, serious primary disease such as no cardiovascular, liver, kidney and psychosis.
Dosage regimen: oral dosage form of the present invention, be equivalent to crude drug amount 4.2g-5.3g at every turn, every day 2 times, the consumption per day of being grown up is equivalent to 1/50th of safe dose.
The course of treatment: 30-90 days.
The produce effects standard: energetic have a vigor, and skin water profit is glossy; Of pink and healthy-looking, wrinkle, mottle are thin out, the skin soft and smooth more beautiful that compacts, sleep full of vitality well, the not sour back of the body of waist is painful, the physiology desire strengthens.
Effective standard: the spiritlessness and weakness sense is eliminated, and energetic have a vigor, happy having a good complexion, and sleep quality obviously improves, and skin water profit is glossy; Of pink and healthy-looking, wrinkle, mottle are thin out, and it is soft and smooth, beautiful that skin compacts, sleep full of vitality well, the not sour back of the body of waist is painful, the physiology desire strengthens.The soft and smooth exquisiteness of skin is glossy, and the skin quality is more apparent young honorable, the thin out or disappearance of wrinkle and mottle, and very, menstrual period are regular on the breast enlargement, and gynaecopathia obviously reduces, harmonious happy, the warmth happiness of life.
Through the total obvious effective rate of rough estimates is 83.9%, and effective percentage is 96.4%.Do not find that in the outpatient service process of clinical application this medicine has obvious adverse reaction, takes safety.
(4) description of drawings
Accompanying drawing is a process chart of the present invention.
(5) specific embodiment:
Embodiment one:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 4 Colla Corii Asini 1 Embryo cervi 2 Radix Puerariaes 5 Fructus Rubies 2
Its preparation method may further comprise the steps:
1) Herba Herminii, Radix Puerariae, Fructus Rubi are extracted 2 times: add 8 times of amounts of raw material, 40% ethanol for the first time and boil back to heat up in a steamer and extracted 2 hours, extracting solution recovery ethanol filters stand-by; Add for the second time 8 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are that 0.05Mpa, temperature are to be evaporated to relative density 1.12 under 70 ℃ of conditions at vacuum pressure, use the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6% with drying equipment at 60～80 ℃, crosses 40 mesh sieves, adds 2 parts of magnesium stearate, uses the mixer mixing, incapsulates.
Embodiment two:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 12 Colla Corii Asini 5 Embryo cervi 10 Radix Puerariaes 15 Fructus Rubies 10
Its preparation method may further comprise the steps:
1) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
2) Herba Herminii, Radix Puerariae, Fructus Rubi are extracted 3 times: add 10 times of amounts of raw material, 40% ethanol for the first time and boil back to heat up in a steamer and extracted 3 hours, extracting solution recovery ethanol filters stand-by; Add 10 times of water gagings of raw material for the second time and for the third time and boil extraction 2 hours, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are that 0.06Mpa, temperature are to be evaporated to relative density 1.12～1.18 under 75 ℃ of conditions at vacuum pressure, use the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6.0% with drying equipment at 60-80 ℃, crosses 40 mesh sieves, adds 5 parts of dextrin, uses the mixer mixing, is pressed into tablet.
Embodiment three:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 8 Colla Corii Asini 3 Embryo cervi 7 Radix Puerariaes 10 Fructus Rubies 6
Its preparation method may further comprise the steps:
1) Herba Herminii, Radix Puerariae, Fructus Rubi are extracted 2 times: add 6 times of amounts of raw material, 40% ethanol for the first time and boil back to heat up in a steamer and extracted 1.5 hours, extracting solution recovery ethanol filters stand-by; Add for the second time 6 times of water gagings of raw material and boil extraction 1 hour, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are that 0.04Mpa, temperature are to be evaporated to relative density 1.12～1.18 under 65 ℃ of conditions at vacuum pressure, use the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6.0% with drying equipment at 60-80 ℃, crosses 40 mesh sieves, adds 3 parts of steviosin, uses the mixer mixing, makes granule.
Embodiment four:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 4 Colla Corii Asini 1 Embryo cervi 2 Radix Puerariaes 5 Fructus Rubies 2 Semen Ziziphi Spinosaes 5 Semen Cassiaes 2
Its preparation method may further comprise the steps:
1) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
2) Herba Herminii, Radix Puerariae, Fructus Rubi, Semen Ziziphi Spinosae, Semen Cassiae are extracted 2 times: add 6 times of amounts of raw material ethanol for the first time and boil back to heat up in a steamer and extracted 1.5 hours, extracting solution recovery ethanol filters stand-by; Add for the second time 6 times of water gagings of raw material and boil extraction 1 hour, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are 0.04MPa at vacuum pressure, and temperature is to be concentrated into relative density 1.12～1.18 under 65 ℃ of conditions, uses the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6.0% with drying equipment at 60-80 ℃, crosses 40 mesh sieves, adds 2 parts of dextrin, uses the mixer mixing, incapsulates.
Embodiment five:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 12 Colla Corii Asini 5 Embryo cervi 10 Radix Puerariaes 15 Fructus Rubies 10 Semen Ziziphi Spinosaes 15 Semen Cassiaes 10
Its preparation method may further comprise the steps:
1) Herba Herminii, Radix Puerariae, Fructus Rubi, Semen Ziziphi Spinosae, Semen Cassiae are extracted 3 times: add 10 times of amounts of raw material ethanol for the first time and boil back to heat up in a steamer and extracted 3 hours, extracting solution recovery ethanol filters stand-by; Add 10 times of water gagings of raw material for the second time and for the third time and boil extraction 2 hours, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are 0.06MPa at vacuum pressure, and temperature is to be concentrated into relative density 1.12～1.18 under 75 ℃ of conditions, uses the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6.0% with drying equipment at 60-80 ℃, crosses 40 mesh sieves, adds 7 parts of starch, uses the mixer mixing, is pressed into tablet.
Embodiment six:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 8 Colla Corii Asini 3 Embryo cervi 6 Radix Puerariaes 10 Fructus Rubies 6 Semen Ziziphi Spinosaes 10 Semen Cassiaes 6
Its preparation method may further comprise the steps:
1) Herba Herminii, Radix Puerariae, Fructus Rubi, Semen Ziziphi Spinosae, Semen Cassiae are extracted 2 times: add 8 times of amounts of raw material ethanol for the first time and boil back to heat up in a steamer and extracted 2 hours, extracting solution recovery ethanol filters stand-by; Add for the second time 8 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are 0.05MPa at vacuum pressure, and temperature is to be concentrated into relative density 1.12～1.18 under 70 ℃ of conditions, uses the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) Macrogol 4000 and polyethylene glycol 6000 are mixed, under 65 ℃～85 ℃ constant temperatures, dissolve, add the material after sterilization, mixture is splashed in the methyl-silicone oil coolant make drop pill.Macrogol 4000 is 5 parts, and polyethylene glycol 6000 is 3 parts.
Embodiment seven:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 8 Colla Corii Asini 3 Embryo cervi 6 Radix Puerariaes 10 Fructus Rubies 6 Semen Ziziphi Spinosaes 10 Semen Cassiaes 6
Herba Epimedii 15 Fructus Lycii 13 soybean extract 3 Rhizoma Polygonatis 6 Poria 10 Radix Paeoniae Albas 7 Fructus Gardeniaes 6
Its preparation method may further comprise the steps:
1) Semen Ziziphi Spinosae, Herba Epimedii, Fructus Rubi, Semen Cassiae, Herba Herminii, the Radix Paeoniae Alba, Fructus Lycii, Poria, Fructus Gardeniae, Radix Puerariae, Rhizoma Polygonati are extracted 2 times: add 8 times of amounts of raw material, 40% ethanol for the first time and boil back to heat up in a steamer and extracted 2 hours, extracting solution recovery ethanol filters stand-by; Add for the second time 8 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are 0.05MPa at vacuum pressure, and temperature is to be concentrated into relative density 1.12～1.18 under 70 ℃ of conditions, with about 180 ℃ of spray dryer dry extract spray dryer inlet temperature, about 120 ℃ of leaving air temp.
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder, deer fetus powder and the soybean extract mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6.0% with drying equipment at 60-80 ℃, crosses 40 mesh sieves, adds 11 parts of calcium carbonate, uses the mixer mixing, incapsulates.
Embodiment eight:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 4 Colla Corii Asini 1 Embryo cervi 2 Radix Puerariaes 5 Fructus Rubies 2 Semen Ziziphi Spinosaes 5 Semen Cassiaes 2
Herba Epimedii 10 Fructus Lycii 5 soybean extract 1 Rhizoma Polygonati 2 Poria 5 Radix Paeoniae Albas 2 Fructus Gardeniaes 2
Its preparation method may further comprise the steps:
1) Semen Ziziphi Spinosae, Herba Epimedii, Fructus Rubi, Semen Cassiae, Herba Herminii, the Radix Paeoniae Alba, Fructus Lycii, Poria, Fructus Gardeniae, Radix Puerariae, Rhizoma Polygonati are extracted 2 times: add 6 times of amounts of raw material, 40% ethanol for the first time and boil back and heat up in a steamer extraction 1.5 hours, extracting solution reclaims ethanol, filters stand-by; Add for the second time 6 times of water gagings of raw material and boil extraction 1 hour, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are 0.04MPa at vacuum pressure, and temperature is to be concentrated into relative density 1.12～1.18 under 65 ℃ of conditions, with about 180 ℃ of spray dryer dry extract spray dryer inlet temperature, about 120 ℃ of leaving air temp.
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder, deer fetus powder and the soybean extract mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6.0% with drying equipment at 60-80 ℃, crosses 40 mesh sieves, adds 5 parts of carboxymethyl starch sodium, uses the mixer mixing, is pressed into tablet.
Embodiment nine:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 12 Colla Corii Asini 5 Embryo cervi 10 Radix Puerariaes 15 Fructus Rubies 10 Semen Ziziphi Spinosaes 15 Semen Cassiaes 10
Herba Epimedii 20 Fructus Lycii 5 soybean extract 1 Rhizoma Polygonati 2 Poria 5 Radix Paeoniae Albas 2 Fructus Gardeniaes 2
Its preparation method may further comprise the steps:
1) Semen Ziziphi Spinosae, Herba Epimedii, Fructus Rubi, Semen Cassiae, Herba Herminii, the Radix Paeoniae Alba, Fructus Lycii, Poria, Fructus Gardeniae, Radix Puerariae, Rhizoma Polygonati are extracted 3 times: add 10 times of amounts of raw material, 40% ethanol for the first time and boil back and heat up in a steamer extraction 3 hours, extracting solution reclaims ethanol, filters stand-by; Add 10 times of water gagings of raw material for the second time and for the third time and boil extraction 2 hours, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are 0.06MPa at vacuum pressure, and temperature is to be concentrated into relative density 1.12～1.18 under 75 ℃ of conditions, uses the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, be dried to moisture content less than 6%, pulverized 120 mesh sieves at 70～80 ℃;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder, deer fetus powder and the soybean extract mix homogeneously;
4) material after sterilization is made powdery granule with facility for granulating, granulates and adopts 85% ethanol wet granulation, is dried to moisture less than 6.0% with drying equipment at 60-80 ℃, crosses 40 mesh sieves, adds 5 parts of aspartames, uses the mixer mixing, makes granule.
Embodiment ten:
Present embodiment mainly comprises the raw material of following weight portion:
Herba Herminii 8 Colla Corii Asini 3 Embryo cervi 6 Radix Puerariaes 10 Fructus Rubies 6 Semen Ziziphi Spinosaes 10 Semen Cassiaes 6
Herba Epimedii 15 Fructus Lycii 12 soybean extract 3 Rhizoma Polygonatis 6 Poria 10 Radix Paeoniae Albas 7 Fructus Gardeniaes 6
Its preparation method may further comprise the steps:
1) with Semen Ziziphi Spinosae, Herba Epimedii, Fructus Rubi, Semen Cassiae
2) Colla Corii Asini is dried to moisture content less than 8% at 70～80 ℃, pulverized 100 mesh sieves; After the Embryo cervi water cleaned 2 times respectively, cut into fritter, being dried to water, Herba Herminii, the Radix Paeoniae Alba, Fructus Lycii, Poria, Fructus Gardeniae, Radix Puerariae, Rhizoma Polygonati at 70～80 ℃ extracts 2 times: add 8 times of amounts of raw material, 40% ethanol for the first time and boil back and heat up in a steamer extraction 2 hours, extracting solution reclaims ethanol, filters stand-by; Add for the second time 8 times of water gagings of raw material and boil extraction 1.5 hours, collect extracting solution; Merge extracted twice liquid, 150 orders filter, and are 0.05MPa at vacuum pressure, and temperature is to be concentrated into relative density 1.12～1.18 under 70 ℃ of conditions, uses the spray dryer dry extract, about 180 ℃ of spray dryer inlet temperature, about 120 ℃ of leaving air temp.Part was pulverized 120 mesh sieves less than 6%;
3) will be sterilization 30 minutes under the 0.068MPa at 115 ℃, air pressure behind Chinese medicine extract, Colla Corii Asini powder, deer fetus powder and the soybean extract mix homogeneously;
4) material after sterilization is in harmonious proportion with 30 parts of salad oils, uses the vibrating ball-mill mixing, incapsulates in the spice bucket of machine standby;
5) get gelatin: glycerol: water: red ferric oxide=100: 40: 100: 2.0, make sizing material in the inputization glue jar, incapsulate in the sizing material bucket of machine standby;
6) sizing material bucket and spice bucket are delivered to capsule machine top making soft capsule.
Soybean extract is with the product of Semen sojae atricolor gained after water or ethanol extraction concentrate, and comprises soybean isoflavone, soyasaponins, soybean phospholipid, soybean oligo saccharide, soybean protein, Semen sojae atricolor vitamin E etc.
Above dosage form capsule, soft capsule, drop pill, tablet or particulate preparation method are conventional method.
Claims (6)
1. a QI invigorating and blood producing, the kidney invigorating care preparation is characterized in that it mainly comprises the raw material of following weight portion:
Herba Herminii 4-12, Colla Corii Asini 1-5, Embryo cervi 2-10, Radix Puerariae 5-15, Fructus Rubi 2-10.
2. QI invigorating and blood producing according to claim 1, the kidney invigorating care preparation is characterized in that wherein crude drug also has Semen Ziziphi Spinosae 5-15, Semen Cassiae 2～10.
3. QI invigorating and blood producing according to claim 2, the kidney invigorating care preparation is characterized in that wherein crude drug also has Herba Epimedii 10-20, Fructus Lycii 5-20, soybean extract 1-5, Rhizoma Polygonati 2-10, Poria 5-15, Radix Paeoniae Alba 2-12, Fructus Gardeniae 2-10.
4. the preparation method of a QI invigorating and blood producing, the kidney invigorating care preparation is characterized in that may further comprise the steps:
1) 4～12 weight portion Herba Herminii, 5～15 weight portion Radix Puerariaes, 2～10 weight portion Fructus Rubies are extracted 2 times: add 6～10 times of amounts of raw material, 40% ethanol for the first time and boil back to heat up in a steamer and extracted 1.5～3 hours, extracting solution recovery ethanol filters stand-by; Add for the second time 6～10 times of water gagings of raw material and boil extraction 1～2 hour, collect extracting solution; Merge extracted twice liquid, filter, be concentrated into relative density 1.12～1.18, dry extract;
2) 1～5 weight portion Colla Corii Asini and 2～10 weight portion Embryo cervi pulverize separately are sieved;
3) will sterilize behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) the material pelletization after drying after sterilization, the mixing that sieves incapsulates, or makes drop pill, or is pressed into tablet, or makes granule.
5. the preparation method of a QI invigorating and blood producing, the kidney invigorating care preparation is characterized in that may further comprise the steps:
1) 4～12 weight portion Herba Herminii, 5～15 weight portion Radix Puerariaes, 2～10 weight portion Fructus Rubies, 5～15 weight portion Semen Ziziphi Spinosaes, 2～10 weight portion Semen Cassiaes are extracted 2 times: add 6～10 times of amounts of raw material ethanol for the first time and boil back and heat up in a steamer extraction 1.5～3 hours, extracting solution reclaims ethanol, filters stand-by; Add for the second time 6～10 times of water gagings of raw material and boil extraction 1～2 hour, collect extracting solution; Merge extracted twice liquid, filter, be concentrated into relative density 1.12～1.18, dry extract;
2) 1～5 weight portion Colla Corii Asini and 2～10 weight portion Embryo cervi pulverize separately are sieved;
3) will sterilize behind Chinese medicine extract, Colla Corii Asini powder and the deer fetus powder mix homogeneously;
4) the material pelletization after drying after sterilization, the mixing that sieves incapsulates, or makes drop pill, or is pressed into tablet, or makes granule.
6. the preparation method of a QI invigorating and blood producing, the kidney invigorating care preparation is characterized in that may further comprise the steps:
1) 5～15 weight portion Semen Ziziphi Spinosaes, 10～20 weight portion Herba Epimedii, 2～10 weight portion Fructus Rubies, 2～10 weight portion Semen Cassiaes, 4～12 weight portion Herba Herminii, 2～12 weight portion Radix Paeoniae Albas, 5～20 weight portion Fructus Lycii, 5～15 weight portion Poria, 2～10 weight portion Fructus Gardeniaes, 5～15 weight portion Radix Puerariaes, 2～10 weight portion Rhizoma Polygonatis are extracted 2 times: add 6～10 times of amounts of raw material, 40% ethanol for the first time and boil back and heat up in a steamer extraction 1.5～3 hours, extracting solution reclaims ethanol, filters stand-by; Add for the second time 6～10 times of water gagings of raw material and boil extraction 1～2 hour, collect extracting solution; Merge extracted twice liquid, filter, be concentrated into relative density 1.12～1.18, dry extract;
2) 1～5 weight portion Colla Corii Asini and 2～10 weight portion Embryo cervi pulverize separately are sieved;
3) will sterilize behind Chinese medicine extract, Colla Corii Asini powder, deer fetus powder and 1～5 weight portion soybean extract mix homogeneously;
4) the material pelletization after drying after sterilization, the mixing that sieves incapsulates, or makes drop pill, or is pressed into tablet, or makes granule.
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| CN2006100224506A CN1969975B (en) | 2006-12-08 | 2006-12-08 | Formulation for replenishing qi, regenerating blood, tonigying kidney and nourishing face and method for preparing same |
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| CN2006100224506A CN1969975B (en) | 2006-12-08 | 2006-12-08 | Formulation for replenishing qi, regenerating blood, tonigying kidney and nourishing face and method for preparing same |
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| CN101337025B (en) * | 2008-08-18 | 2011-01-26 | 西藏央科生物科技有限公司 | Oral preparation capable of anti-aging, whitening, moistening skin and relieving restlessness and preparation method thereof |
| CN102885182A (en) * | 2011-07-20 | 2013-01-23 | 陈来祝 | Runsheng herbal tea and preparation method thereof |
| CN106260459A (en) * | 2016-09-15 | 2017-01-04 | 天津替代医学科技股份有限公司 | One fills blood the confectionery industry |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386844A (en) * | 2002-03-08 | 2002-12-25 | 孙淑英 | Deer fetus wine and its preparing process |
| CN1461654A (en) * | 2002-05-31 | 2003-12-17 | 李景太 | Medicinal extract for tonifying kidney and enriching blood made from foetal fuzz, and its prepn. method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386844A (en) * | 2002-03-08 | 2002-12-25 | 孙淑英 | Deer fetus wine and its preparing process |
| CN1461654A (en) * | 2002-05-31 | 2003-12-17 | 李景太 | Medicinal extract for tonifying kidney and enriching blood made from foetal fuzz, and its prepn. method |
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Effective date of registration: 20191204 Address after: 850000 Lhasa economic and Technological Development Zone, Tibet City, Lhasa Road, No. 9 Patentee after: TIBET YUEWANG TIBETAN MEDICINE TECHNOLOGY CO.,LTD. Address before: 618300 Chengdu Chengdu ABA industrial concentrated development zone, Sichuan, China Patentee before: Sichuan King month eco Tibetan Pharmaceutical Co.,Ltd. |