CN100341540C - Angelica root mistletoe granules and its preparation method - Google Patents
Angelica root mistletoe granules and its preparation method Download PDFInfo
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- CN100341540C CN100341540C CNB2004100408604A CN200410040860A CN100341540C CN 100341540 C CN100341540 C CN 100341540C CN B2004100408604 A CNB2004100408604 A CN B2004100408604A CN 200410040860 A CN200410040860 A CN 200410040860A CN 100341540 C CN100341540 C CN 100341540C
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Abstract
The present invention discloses a mistletoe granule with radix angelicae pubescentis for treating rheumatism, and a preparation method thereof. In the method, radix angelicae pubescentis, loranthus parasiticus, gentiana macrophylla, ledebouriella roots, wild ginger, angelica, radix paeoniae alba, hemlock parsley, prepared rhizome of rehmannia, eucommia bark, radix cyathulae, codonopsis pilosula, tuckahoe, licorice roots and cassia twigs are adopted as the raw materials, wherein volatile oil is extracted out of the radix angelicae pubescentis, the ledebouriella roots, the wild ginger, the angelica, the hemlock parsley and the cassia twigs, drug dregs are the remaining nine kinds of drugs are percolated after impregnated for a plurality of hours by the percolation method for fluid extracts and extracts, the percolated solution is decompressed and concentrated after collected, and the granule is obtained after proper amount of auxiliary materials are added. The present invention has the advantages that both the formulation and the preparation process are unique, and the therapeutic effects are obvious.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rheumatic Bi syndrome.Be the Chinese patent medicine of feedstock production specifically, the invention still further relates to the preparation method of this medicine with the Chinese herbal medicine.
Background technology
What rheumatism was that a variety of causes causes serves as a class disease of main performance with BJM and affiliated group's pain thereof, and this disease sickness rate is higher, and disability rate height and clinical manifestation differ, and the course of disease is longer, and prognosis is relatively poor, seriously jeopardizes human health.
At present, it is 10 classes that Americanism damp disease association (ARA) is divided into rheumatism, adopted by World Health Organization (WHO), these diseases mainly contain rheumatic arthritis, rheumatoid arthritis, proliferative arthritis, polyarteritis nodosa etc., wherein occurred frequently with several diseases such as rheumatism and rheumatoid arthritis, osteoarthritis, gout, tetanic property, spondylitiss especially, poor prognosis, disability rate is higher.
Now, at this sick medicine for the treatment of non-hormone anti-inflammatory agent, hormone medicine, Chinese medicine preparation are arranged both at home and abroad.The non-hormone anti-inflammatory agent is the common drug of treatment rheumatoid arthritis, and its anti-inflammatory and analgesic effect is strong, but untoward reaction is more, and is especially big with reference to the gastrointestinal toxic and side effects, the unsuitable prolonged application of patient; The hormone medicine antiinflammatory action is powerful, can alleviate RA patient's symptom rapidly, but great mass of data shows, constantly blocks course of disease progress and the carrying out property destruction of joint of RA, and the harm of this product side effect of prolonged application and iatrogenic disease and be not less than even greater than the harm of RA itself; Some inhibitor also is used to treat RA, but this class medicine is nonspecific, and toxicity is bigger; And Chinese medicine has unique curative effect in this regard, as DUHUO JISHENG HEJI.
DUHUO JISHENG HEJI is made up of Radix Angelicae Pubescentis, Herba Taxilli, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Codonopsis, the Cortex Eucommiae (salt is processed), Radix Cyathulae, Poria, Radix Glycyrrhizae, Ramulus Cinnamomi ten five kinds of Chinese medicine, has the effect of tonifying the blood and stretching the tendon, expelling wind and removing dampness; The clinical anemofrigid-damp arthralgia that is used for, chills and pain of the waist and kness, joint stuffiness.
The preparation method of DUHUO JISHENG HEJI is as follows: Radix Gentianae Macrophyllae, the Radix Paeoniae Alba and the Cortex Eucommiae are made solvent according to the percolation under the fluid extract item with 70% ethanol, carry out percolation, diacolation liquid recycling ethanol; Radix Angelicae Pubescentis, Herba Asari, Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong and Radix Angelicae Sinensis distillating extracting oil; Medicinal residues and all the other Six-elements decoct with water secondary, and collecting decoction filters, and filtrate is concentrated in right amount, merge with the liquid of filtering, and leave standstill, and filter, and reconcentration is to about 760ml, put coldly, and adding ethanol 240ml and above-mentioned volatile oil add water to 1000ml, stir evenly, promptly.As seen, this dosage form is to contain the higher preparation of alcohol amount, and the shortcoming that a large amount of ethanol exists is except that the cost that increases product, and main is bigger to GI irritation, it is uncomfortable to take the normal sense in back, even can cause vomiting, not easy for patients to accept, influenced the normal performance of curative effect, to the ethanol allergy sufferers, or old man, child, and also all should not take the patient of alcohol prohibitions such as heating, vomiting, gastrointestinal ulceration, the treatment target scope is restricted.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical preparation Duhuo jisheng granule that does not have alcohol, treatment rheumatism numbness that active constituent content is high.
Another object of the present invention is to provide the preparation method of this treatment rheumatic Bi syndrome pharmaceutical preparation.
Solution of the present invention is based on tradition side's plus-minus of Sun Simiao, with reference to modern pharmacological research, the achievement of modern preparation process, by the theory of Chinese medical science prescription, extract its elite composition, make its strengthening vital QI to eliminate pathogenic factors that meets the Chinese traditional treatment rheumatism, treatment must aim at the pathogenesis of disease, giving consideration to both the incidental and fundamental, dialectical executing control principle, can more effectively alleviate RA patient's symptom.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Radix Angelicae Pubescentis 5-15, Herba Taxilli 4-10, Radix Gentianae Macrophyllae 4-10, Radix Saposhnikoviae 4-10, Herba Asari 4-10, Radix Angelicae Sinensis 4-10, Radix Paeoniae Alba 4-10, Rhizoma Chuanxiong 4-10, Radix Rehmanniae Preparata 4-10, Cortex Eucommiae 4-10, Radix Cyathulae 4-10, Radix Codonopsis 4-10, Poria 4-10, Radix Glycyrrhizae 4-10, Ramulus Cinnamomi 4-10
The optimum weight of medicine of the present invention (part) proportioning is:
Radix Angelicae Pubescentis 9, Herba Taxilli 6, Radix Gentianae Macrophyllae 6, Radix Saposhnikoviae 6, Herba Asari 6, Radix Angelicae Sinensis 6, the Radix Paeoniae Alba 6, Rhizoma Chuanxiong 6, Radix Rehmanniae Preparata 6, the Cortex Eucommiae 6, Radix Cyathulae 6, Radix Codonopsis 6, Poria 6, Radix Glycyrrhizae 6, Ramulus Cinnamomi 6.
Above-mentioned each component is made medicine production method of the present invention is:
1. getting Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Cinnamomi earlier adds 6～10 times of water gagings and extracts volatile oil;
2. medicinal residues and all the other nine flavors are made solvent with 60%～80% ethanol behind the extraction volatile oil, flood;
3. flood and collect 6～8 times of amount percolates after 30～60 hours, decompression recycling ethanol also is concentrated into relative density 1.20～1.40 (40～50 ℃)
4. add right amount of auxiliary materials and make granule.
Preparation method of the present invention is Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Cinnamomi extraction volatile oil; Medicinal residues and all the other nine flavors are according to the percolation under fluid extract and the extractum item, and dipping carries out percolation after a few hours, collects percolate, and concentrating under reduced pressure adds appropriate amount of auxiliary materials and makes granule again.Here the extraction of said volatile oil can be with water extraction or other desirable suitable modes.Extracted the medicinal residues of volatile oil, comprise mother solution and residue can with the common percolation of all the other nine herbal medicines, the percolate reclaim under reduced pressure also concentrates, and adds the appropriate amount of auxiliary materials adjuvant of usefulness (comprise can).
An important feature of the present invention be by purification after this preparation method effective ingredient and reduced alcoholic acid content fully, patient's dose is reduced, avoided in the preparation too much impurity effect medicine stability.
For showing medicine that preparation method of the present invention the obtains medical effect to rheumatic Bi syndrome, the spy does following evidence:
One, experiment material
1.1 be subjected to the reagent thing
Title: the drug extract (to call the Duhuo jisheng granule in the following text) that adopts preparation method of the present invention to make is provided lot number: 020701 by Chongqing Hil'an Pharmaceutical Co., Ltd.
Content: 3g crude drug/ml.
Character: pitchy thick liquid; Gas fragrance; Bitter in the mouth.
Route of administration: gastric infusion.
Preparation: join with distilled water as required and be variable concentrations.
1.2 dosage design
Recommend clinical adult's dosage according to the Duhuo jisheng granule: 0.86g crude drug/kg (in 55kg), the clinical adult's dosage of DUHUO JISHENG HEJI: 1.0g crude drug/kg (in 55kg), Duhuo jisheng granule dosage group: dosage is 17.2g/kg (be equivalent to respectively recommend clinical dosage 20 times), DUHUO JISHENG HEJI is former dosage form matched group, and dosage is 20g/kg (be equivalent to clinical dosage 20 times).
Two, antiinflammatory action
The influence of 1 xylol induced mice ear swelling
1.1 purpose
The influence of observation sample xylol induced mice ear swelling acute inflammation model.
1.2 experiment material
1.2.1 control drug
Dexamethasone: Qingyang, Chongqing pharmaceutcal corporation, Ltd provides lot number: 040205.
1.2.2 laboratory animal
Kunming mouse, 40, male and female half and half, SPF level animal, the quality certification number: No. 20020004, SCXK (Chongqing), the court animal housing provides.
1.2.3 key instrument and reagent
AW220 type electronic balance: Japanese SHIMADZU company produces.
Dimethylbenzene: east, Chongqing chemical reagent work provides lot number: 990102.
1.3 method and result
Get 40 of 18-22g mices and be divided into 4 groups at random, 10 every group, the according to the form below gastric infusion, once a day, for three days on end, matched group gives the physiological salt liquid of equal volume.After the last administration 1 hour, only smear dimethylbenzene 0.03ml/ in mouse right ear, take off neck after 20 minutes and put to death animal, card punch is laid animal left and right sides ear, precision takes by weighing auricle weight, calculate ear swelling degree (auris dextra weight-left ear weight) and swelling rate (swelling degree/left ear weight * 100%), the results are shown in Table 1:
The influence of table 1 xylol induced mice ear swelling (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | Swelling degree (mg) | Swelling rate (%) |
| Matched group Duhuo jisheng granule DUHUO JISHENG HEJI dexamethasone | / 17.2 20 0.005 | 10 10 10 10 | 16.43±3.84 11.20±2.44* 11.73±3.04 3.92±0.75** | 126.04±31.30 83.93±22.03* 87.42±19.15 31.52±4.63** |
Annotate: * is for comparing P＜0.05 with matched group, * * is for comparing P＜0.01 with matched group.
By table 1 as seen: the Duhuo jisheng granule has obvious suppression effect and action intensity greater than DUHUO JISHENG HEJI at xylol induced mice ear swelling.
The influence of rat paw edema due to 2 on Carrageenan
2.1 purpose
The influence of rat paw edema inflammatory model due to the observation sample on Carrageenan.
2.2 test material
2.2.1 control drug
Dexamethasone: Qingyang, Chongqing pharmaceutcal corporation, Ltd provides lot number: 040205.
2.2.2 experimental animal
The Wistar rat, 40, complete male, SPF level animal, the quality certification number: No. 20020004, SCXK (Chongqing), the court animal housing provides.
2.2.3 key instrument and reagent
Foot volume determination instrument: model: 7140 PLETHYSMOMRETER, produced by UGO BASILE S.R.L..
Carrageenin: the institute of Chinese materia medica, Jilin Province provides.
2.3 method and result
Get 40 of rats and be divided into 4 groups at random, 10 every group, the according to the form below gastric infusion, once a day, for three days on end, matched group gives the physiological salt liquid of equal volume.Measure rat normal foot volume (twice, get average) before the last administration, after the last administration 30 minutes, carrageenin 0.05ml in rat left side foot subcutaneous injection 1% causes inflammation, measure respectively and cause scorching back 1,3,6,8 hour rat foot volume, calculate the foot swelling rate, the results are shown in Table 2:
The influence of rat paw edema due to table 2 on Carrageenan (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | To swelling rate behind the carrageenin | |||
| 1h | 3h | 6h | 8h | |||
| Matched group Duhuo jisheng granule DUHUO JISHENG HEJI dexamethasone | / 17.2 20 0.005 | 10 10 10 10 | 15.84±5.59 13.76±4.52 13.22±5.18 10.84±4.44* | 38.87±13.01 25.94±10.21* 28.38±12.48* 13.46±5.30** | 50.36±17.53 37.69±11.58* 39.15±13.60 19.91±7.69** | 51.05±20.81 43.08±11.54 40.18±15.32 21.62±6.81** |
Annotate: * is for comparing P＜0.05 with matched group, * * is for comparing P＜0.01 with matched group.
By last table 2 as seen: aspect the action intensity of Duhuo jisheng granule rat paw edema due on Carrageenan greater than DUHUO JISHENG HEJI.
Two, analgesic activity
The influence of 1 pair of mice hot plate pain threshold
1.1 purpose
Observation sample is to the influence of mice thermostimulation pain.
1.2 test material
1.2.1 control drug
Morphine hydrochloride: Shenyang No. 1 Pharmaceutical Factory provides, lot number: 010322.
1.2.2 experimental animal
Kunming mouse, 40, female entirely, SPF level animal, the quality certification number: No. 20020004, SCXK (Chongqing), the court animal housing provides.
1.2.3 key instrument and reagent
The autocontrol temperature hot-plate instrument: the Academy of Medical Sciences, Shandong provides, model: X2C-2B.
1.3 method and result
Get the mice (threshold of pain primary dcreening operation after the screening, lick sufficient time＜6 second,＞30 seconds or leaper all discard) 40 be divided into 4 groups at random, every group 10, measure behind the normal threshold of pain of each Mus (twice, get average), the according to the form below administration, once a day, for three days on end, matched group gives the physiological salt liquid of equal volume.Morphine group subcutaneous injection is administered once.The threshold of pain of 30 minutes, 60 minutes, 90 minute three time periods after the administration of mensuration last the results are shown in Table 3:
The influence of the table 3 pair mice hot plate threshold of pain (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | The threshold of pain (s) | |||
| Before the administration | Behind the medicine 30 minutes | 60 minutes | 90 minutes | |||
| Matched group Duhuo jisheng granule DUHUO JISHENG HEJI morphine | / 17.2 20 0.0075 | 10 10 10 10 | 18.40±3.23 18.75±3.88 18.75±3.98 17.95±2.63 | 18.70±4.06 20.20±4.61 20.60±5.19 37.20±7.67** | 19.10±4.56 22.20±4.61 21.60±5.19 38.70±6.86** | 17.20±5.31 18.90±4.91 18.50±5.38 27.80± 5.61** |
Annotate: * is for comparing P＜0.05 with matched group, * * is for comparing P＜0.01 with matched group.
By table 3 as seen: Duhuo jisheng granule and DUHUO JISHENG HEJI have certain prolongation effect to the mice hot plate threshold of pain, but not statistically significant.Prompting Duhuo jisheng granule and mixture do not have obvious analgesic activity to the pain of thermostimulation.
2 Dichlorodiphenyl Acetate induced mice are turned round the influence of body number of times
2.1 purpose
Observation sample is to the influence of mice chemical stimulation pain.
2.2 test material
2.2.1 control drug
Aspirin: Jiangsu Huang He Pharmaceutical Co., Ltd provides, lot number: 031010.
2.2.2 experimental animal
Kunming mouse, 40, male and female half and half, SPF level animal, the quality certification number: No. 20020004, SCXK (Chongqing), the court animal housing provides.
2.2.3 key instrument and reagent
Glacial acetic acid: chemical reagent factory in Chongqing provides lot number: 990714.
2.3 method and result
Get 40 of 18-22g mices and be divided into 4 groups at random, 10 every group, the according to the form below administration, once a day, for three days on end, matched group gives the physiological salt liquid of equal volume.After the last administration 1 hour, the glacial acetic acid liquid 0.2ml/ of lumbar injection 0.7% only write down mouse writhing number of times and incubation period in 20 minutes.The results are shown in Table 4:
The influence of table 4 pair mouse writhing incubation period and number of times (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | Incubation period | Turn round the body number of times |
| (s) | (only) | |||
| Matched group Duhuo jisheng granule DUHUO JISHENG HEJI aspirin | / 17.2 20 0.2 | 10 10 10 10 | 3.62±0.50 4.13±0.83 3.74±0.65 4.43±0.89* | 39.40±9.79 29.73±7.35** 35.44±6.37 19.30±7.02** |
Annotate: * is for to compare P＜0.05 with the NS matched group, and * * is for to compare P＜0.01 with the NS matched group.
By table 4 as seen: the Duhuo jisheng granule obviously reduce acetic acid stimulate cause turn round the body number of times, but to there not being obvious shadow incubation period
Three, immunization
The influence that the normal mouse hemolytic antibody generates due to 1 pair of chicken red blood cell (CRBC)
1.1 purpose
Observation sample is to the influence of the inductive circulating antibody level of antigen.
1.2 test material
1.2.1 control drug
Cyclophosphamide: Hualian Pharmaceutical Co., Ltd., Shanghai provides, lot number: 030407.
1.2.2 experimental animal
The NIH mice, 40, body weight 20 ± 2g, male and female half and half, SPF level animal, the quality certification number: No. the 310101005th, the moving word of doctor, animal housing of Medical University Of Chongqing provides.
Key instrument and reagent
Glacial acetic acid: chemical reagent factory in Chongqing provides lot number: 990714.
722 type spectrophotometers: Chongqing Chuanyi No.9 Factory provides.
LD5-2A type centrifuge: Beijing Medical Centrifugal Machine Factory provides.
Electric-heated thermostatic water bath: Beijing's armarium head factory provides.
1.3 method and result
Get 40 of NIH mices, male and female half and half are divided into 4 groups at random, 10 every group.Each is organized the equal iP5%CRBC0.2ml of mice and carries out immunity.Medicine shown in the according to the form below, dosage is gastric infusion once a day, continuous 7 days, the cyclophosphamide subcutaneous injection, the next day once, totally 3 times.Behind administration 7d last medicine 1 hour, eye socket was got blood 20ml, added after the 2ml normal saline mixes, and added 4% CRBC liquid 0.5ml and 10% guinea pig serum 0.5ml again.Put into 37 ℃ of waters bath with thermostatic control 30 minutes behind the mixing, take out cessation reaction in the rearmounted ice bath, centrifugal 10 minutes of 2000rpm, every pipe is got supernatant 1ml and is added 3ml Dou Shi liquid, after leaving standstill 10 minutes, in 722 type spectrophotometer 540nm wavelength colorimetrics, measure optical density (0D value), its 0D * 1000 are the hemolysin value.The results are shown in following table 5:
The influence that the normal mouse hemolytic antibody generates due to table 5 pair chicken red blood cell (CRBC) immunity (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | The hemolysin value |
| Matched group Duhuo jisheng granule DUHUO JISHENG HEJI cyclophosphamide | / 17.2 20 0.02 | 10 10 10 10 | 237.20±49.98 168.10±55.92** 198.10±40.56* 63.50±26.53** |
Annotate: * is for to compare P＜0.05 with the NS matched group, and * * is for to compare P＜0.01 with the NS matched group.
By table 5 as seen: the Duhuo jisheng granule is more obvious than DUHUO JISHENG HEJI effect aspect the generation that suppresses hemolytic antibody.
2 pairs 2, the influence of 4-dinitrofluorobenzene induced mice ear delayed hypersensitivity
2.1 purpose
Observation sample is to the influence of IV paraphilia reaction.
2.2 experiment material
2.2.1 control drug
Dexamethasone: Qingyang, Chongqing pharmaceutcal corporation, Ltd provides lot number: 040205.
2.2.2 laboratory animal
The NIH mice, 40, body weight 20 ± 2g, male and female half and half, SPF level animal, the quality certification number: No. the 310101005th, the moving word of doctor, animal housing of Medical University Of Chongqing provides.
2.2.3 key instrument and reagent
AW220 type electronic balance: Japanese SHIMADZU company produces.
2, the 4-dinitrofluorobenzene: Shanghai chemical reagents corporation provides, lot number: F 20020315
2.3 method and result
Get 40 of NIH mices, male and female half and half are divided into 4 groups at random, 10 every group.Each organizes the mouse web portion cropping, and (scope is 3 * 3cm2), and 1%DNFB solution 30 μ l/ only evenly are applied on the skin of unhairing, and the next day strengthens once again.The gastric infusion once a day of medicine, dosage shown in the 1st day according to the form below after the sensitization, control group administered physiological saline, continuous 6 days.After the sensitization the 5th day, 1%DNFB solution 10 μ l/ only evenly are applied in respectively organize the mouse right ear two sides and attack, to attack back 24 hours, mice is put to death in the cervical vertebra dislocation, cuts left and right sides auricular concha and weighs respectively, gets mouse thymus simultaneously and spleen is weighed respectively.Calculate swelling degree (auris dextra sheet weight-left ear is heavy) and index and spleen index and thymus index.The results are shown in following table 6:
Table 6 pairs 2, and the influence of 4-dinitrofluorobenzene induced mice ear delayed hypersensitivity (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | The swelling degree | Index and spleen index | Thymus index |
| Matched group Duhuo jisheng granule DUHUO JISHENG HEJI dexamethasone | / 17.2 20 0.005 | 10 10 10 10 | 38.45±7.10 35.76±9.52 34.93±10.96 2.61±1.88** | 4.79±0.83 4.75±0.89 4.42±0.91 0.62±0.27** | 4.09±1.28 3.89±0.95 3.72±0.64 2.56±0.71** |
Annotate: * is for to compare P＜0.05 with the NS matched group, and * * is for to compare P＜0.01 with the NS matched group.
By table 6 as seen: Duhuo jisheng granule and DUHUO JISHENG HEJI are to 2, and the equal unrestraint effect of ear swelling that 4-dinitrofluorobenzene induced mice ear delayed hypersensitivity causes is simultaneously to spleen and also unrestraint effect of thymus.
More than experiment shows: the medicine Duhuo jisheng granule that adopts preparation method of the present invention to make is better than now commercially available DUHUO JISHENG HEJI at antiinflammatory, analgesia, immune effect.
The specific embodiment
That below introduce is the embodiment of this preparation method, but scope of the present invention is not limited to following example.
Embodiment 1:
Take by weighing raw material (kilogram) by following proportioning
Radix Angelicae Pubescentis 9, Herba Taxilli 6, Radix Gentianae Macrophyllae 6, Radix Saposhnikoviae 6, Herba Asari 6, Radix Angelicae Sinensis 6, the Radix Paeoniae Alba 6, Rhizoma Chuanxiong 6, Radix Rehmanniae Preparata 6, the Cortex Eucommiae 6, Radix Cyathulae 6, Radix Codonopsis 6, Poria 6, Radix Glycyrrhizae 6, Ramulus Cinnamomi 6.
Preparation method is as follows:
More than ten five tastes, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Cinnamomi add 6 times of water gagings and extract volatile oil; Medicinal residues and all the other nine flavors are made solvent with 60% ethanol, flood according to fluid extract and percolation under the extractum item and carry out percolation after 30 hours, collect 6 times and measure percolates, and decompression recycling ethanol also is concentrated into the thick paste of relative density 1.20 (40～50 ℃).It is an amount of that other gets starch, makes granule with thick paste, and drying adds volatile oil, mixing, promptly.
Embodiment 2:
Take by weighing raw material (kilogram) by following proportioning
Radix Angelicae Pubescentis 14, Herba Taxilli 8, Radix Gentianae Macrophyllae 8, Radix Saposhnikoviae 8, Herba Asari 8, Radix Angelicae Sinensis 8, the Radix Paeoniae Alba 8, Rhizoma Chuanxiong 8, Radix Rehmanniae Preparata 8, the Cortex Eucommiae 8, Radix Cyathulae 8, Radix Codonopsis 8, Poria 8, Radix Glycyrrhizae 8, Ramulus Cinnamomi 8.
Preparation method is as follows:
More than ten five tastes, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Cinnamomi add 8 times of water gagings and extract volatile oil; Medicinal residues and all the other nine flavors are made solvent with 70% ethanol, flood according to fluid extract and percolation under the extractum item and carry out percolation after 48 hours, collect 7 times and measure percolates, and decompression recycling ethanol also is concentrated into the thick paste of relative density 1.30 (40～50 ℃).It is an amount of that other gets Aquacoat, makes granule with thick paste, and drying adds volatile oil, mixing, promptly.
Embodiment 3:
Take by weighing raw material (kilogram) by following proportioning
Radix Angelicae Pubescentis 6, Herba Taxilli 5, Radix Gentianae Macrophyllae 5, Radix Saposhnikoviae 5, Herba Asari 5, Radix Angelicae Sinensis 5, the Radix Paeoniae Alba 5, Rhizoma Chuanxiong 5, Radix Rehmanniae Preparata 5, the Cortex Eucommiae 5, Radix Cyathulae 5, Radix Codonopsis 5, Poria 5, Radix Glycyrrhizae 5, Ramulus Cinnamomi 5.
Preparation method is as follows:
More than ten five tastes, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Cinnamomi add 10 times of water gagings and extract volatile oil; Medicinal residues and all the other nine flavors are made solvent with 80% ethanol, flood according to fluid extract and percolation under the extractum item and carry out percolation after 60 hours, collect 8 times and measure percolates, and decompression recycling ethanol also is concentrated into the thick paste of relative density 1.40 (40～50 ℃).Other gets starch, Aquacoat is an amount of, makes granule with thick paste, and drying adds volatile oil, mixing, promptly.
Embodiment 4:
Take by weighing raw material (kilogram) by following proportioning
Radix Angelicae Pubescentis 12, Herba Taxilli 9, Radix Gentianae Macrophyllae 9, Radix Saposhnikoviae 9, Herba Asari 9, Radix Angelicae Sinensis 9, the Radix Paeoniae Alba 9, Rhizoma Chuanxiong 9, Radix Rehmanniae Preparata 9, the Cortex Eucommiae 9, Radix Cyathulae 9, Radix Codonopsis 9, Poria 9, Radix Glycyrrhizae 9, Ramulus Cinnamomi 9.
Preparation method is as follows:
More than ten five tastes, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Cinnamomi add 7 times of water gagings and extract volatile oil; Medicinal residues and all the other nine flavors are made solvent with 70% ethanol, flood according to fluid extract and percolation under the extractum item and carry out percolation after 40 hours, collect 6 times and measure percolates, and decompression recycling ethanol also is concentrated into the thick paste of relative density 1.35 (40～50 ℃).It is an amount of that other gets starch, makes granule with thick paste, and drying adds volatile oil, mixing, promptly.
Claims (3)
1, the particulate preparation method of a kind of Duhuo jisheng, this granule is to be made by following raw medicaments in portion by weight: Radix Angelicae Pubescentis 5～15, Herba Taxilli 4～10, Radix Gentianae Macrophyllae 4～10, Radix Saposhnikoviae 4～10, Herba Asari 4～10, Radix Angelicae Sinensis 4～10, the Radix Paeoniae Alba 4～10, Rhizoma Chuanxiong 4～10, Radix Rehmanniae Preparata 4～10, the Cortex Eucommiae 4～10, Radix Cyathulae 4～10, Radix Codonopsis 4～10, Poria 4～10, Radix Glycyrrhizae 4～10, Ramulus Cinnamomi 4～10 is characterized in that: get Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Ramulus Cinnamomi earlier and add 6～10 times of water gagings and extract volatile oil; Medicinal residues and all the other nine flavors are made solvent with 60%～80% ethanol behind the extraction volatile oil, flood; Flood and collect 6～8 times of amount percolates after 30～60 hours, decompression recycling ethanol also is concentrated into relative density 1.20～1.40, and temperature is 40～50 ℃; Add right amount of auxiliary materials and make granule.
2, the particulate preparation method of Duhuo jisheng as claimed in claim 1, it is characterized in that: described medicinal residues and all the other nine flavors flood and carry out percolation after 48 hours according to the percolation under fluid extract and the extractum item, collect percolate, concentrating under reduced pressure adds appropriate amount of auxiliary materials and makes granule again.
3, the particulate preparation method of Duhuo jisheng as claimed in claim 1 or 2 is characterized in that: described adjuvant is that starch is or/and ethyl cellulose.
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| CN101653510A (en) * | 2009-08-10 | 2010-02-24 | 黄山 | granules for treating rheumatism and strengthening bone |
| CN102552513A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Veterinary traditional Chinese medicine composition having effects of expelling wind-damp and benefiting liver and kidney and preparation method thereof |
| CN102727856B (en) * | 2012-07-13 | 2014-04-02 | 安徽安科余良卿药业有限公司 | Volatile oil for treating arthralgia and injuries of tendons and preparation method of volatile oil |
| CN104138460A (en) * | 2013-09-11 | 2014-11-12 | 金坛韩氏中医关节病专科医院 | Chinese medicinal composition for treatment of pains in necks, waists and legs and preparation method thereof |
| CN104173564B (en) * | 2014-08-25 | 2016-05-18 | 吕红权 | A kind of Chinese medicine composition for the treatment of rheumatoid arthritis |
| CN105079258A (en) * | 2015-09-23 | 2015-11-25 | 刘杰 | Medicine for treating liver and kidney deficiency and qi and blood deficiency type cervical spondylosis |
| CN105477166B (en) * | 2015-12-29 | 2019-11-05 | 广东一方制药有限公司 | A kind of preparation method and its method of quality control of duhuo jisheng decoction granule |
| CN113081972A (en) * | 2021-05-06 | 2021-07-09 | 海南海力制药有限公司 | Preparation method of radix angelicae pubescentis and parasitic loranthus granules |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1362104A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano Angelicae Pubescentis and Loranthis medicine and its preparation |
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| CN1362104A (en) * | 2001-01-04 | 2002-08-07 | 杨孟君 | Nano Angelicae Pubescentis and Loranthis medicine and its preparation |
Non-Patent Citations (1)
| Title |
|---|
| 独活寄生合剂 中华人民共和国卫生部药典委员会，中华人民共和国卫生部药品标准中药成方制剂，第8卷 2003 * |
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