CN107854355A - A kind of anti-apolexis composition and its preparation method and application - Google Patents
A kind of anti-apolexis composition and its preparation method and application Download PDFInfo
- Publication number
- CN107854355A CN107854355A CN201711153833.1A CN201711153833A CN107854355A CN 107854355 A CN107854355 A CN 107854355A CN 201711153833 A CN201711153833 A CN 201711153833A CN 107854355 A CN107854355 A CN 107854355A
- Authority
- CN
- China
- Prior art keywords
- parts
- apolexis composition
- acetyl group
- weight
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a kind of anti-apolexis composition and its preparation method and application, it is related to cosmetic technical field.Wherein anti-apolexis composition includes the component of following parts by weight：15 parts of Chinese prickly ash berry extract；26 parts of polysorbate20；40 60 parts of amino acid；8 30 40 parts of acetyl group hexapeptide；Wherein amino acid is the mixture of arginine and lysine arbitrary proportion.Chinese prickly ash berry extract loosens superficial integumentary musculature from the angle of neurology; reach the effect that lifting is compacted; lysine and arginine promote the synthesis of the matrix components such as collagen from biochemical angle; acetyl group hexapeptide 8 reduces contraction of muscle, improves expression line, four compounding use Synergistics; lift anti-wrinkle effect; smoothed away wrinkles such as " small flatiron ", can also increase skin moisturizing power, delaying skin aging.
Description
Technical field
The present invention relates to cosmetic technical field, more specifically, it relates to a kind of anti-apolexis composition and its preparation side
Method and application.
Background technology
Wrinkle of skin is the distinguishing mark and the form of expression of skin senescence, is that endogenous factor and extrinsic factor are made jointly
Result.Wherein extrinsic factor is included because environmental factor such as daylight, environmental contaminants etc. contact and produce active oxygen certainly
By base, the DNA of Skin Cell and collagen, elastin laminin or the mucopolysaccharide molecule of extracellular matrix are directly injured, so as to which skin becomes
Thin, epidermis and corium, which interweave, to die down and cell quantity and the reduction of supply vesselses quantity, causes facial wrinkles to produce；Due to pressure
The reasons such as power, mood, skin regulatory function is caused to be damaged, so as to produce wrinkle.Endogenous factor refers to advancing age,
The gradual aging of skin, the natural moisturizing factor in horny layer of epidermis is constantly reduced, while proteoglycan and hyalomitome in skin
Acid concentration is reduced, and the moisture of dermal layer of the skin is reduced, and dermal fibroblast activity is reduced, under the ability for synthesizing collagenous fibres
Drop, cause dry skin, skin elasticity weakens, and finally produces wrinkle.
A kind of compound widow for skin repair is disclosed in Publication No. CN106265120A Chinese invention patent
Peptide combinations, according to parts by weight, including 1~30 part of palmityl tripeptides -1,1~30 part of copper of tripeptides -1,1~50 part of palmityl three
- 7,0.1~30 parts of peptide -5,1~30 part of carnosine, 1~30 part of acetyl group tetrapeptide -5,1~30 part of palmityl tetrapeptide acetyl group hexapeptides -
8th, 0.1~30 part of nonapeptide -1,1~30 part of streptococcus lactis peptide.
Suppress aging only with compound peptide molecule in above-mentioned patent, active ingredient species is more single, and skin absorbs peptide
After molecule, the composition to compact is not lifted, anti-aging, anti-wrinkle effect are poor, it is, therefore, desirable to provide a kind of new scheme solves
Above mentioned problem.
The content of the invention
In view of the deficienciess of the prior art, the purpose of the present invention one is to provide a kind of anti-apolexis composition, by adopting
Compounded with Chinese prickly ash berry extract and polypeptide, to solve above-mentioned technical problem, it has reparation skin, anti-aging, anti-wrinkle effect good
The advantages of.
To achieve the above object one, the invention provides following technical scheme：
A kind of anti-apolexis composition, include the component of following parts by weight：
Chinese prickly ash berry extract 1-5 parts；
Polysorbate -202-6 parts；
Amino acid 40-60 parts；
Argireline 30-40 parts；
Wherein amino acid is the mixture of arginine and lysine arbitrary proportion.
Crease-resistant to have two kinds of common strategies using above-mentioned technical proposal, neurology strategy is loosened using botulin toxin
Subdermal muscle, biochemistry strategy is by increasing the synthesis of the matrix components such as collagen.By the body to neuromuscular model
Outer research finds that Chinese prickly ash berry extract plays the role of of short duration to neuromuscular synapse conduction.This activation rapidly results in god
Consumption through mediator, it is adjusted by Voltage-gated Sodium Channels, when Chinese prickly ash fruit extract concentrations reach recommendation dosage, passage
It is closed, so as to block electronic signal transmission, reaches the effect of instantaneous lifts.Distinctive alkylamide in Chinese prickly ash berry extract
(such as Alpha-hydroxy sanshool) can bring skin tight feeling, and have good skin-tolerant, therefore Chinese prickly ash berry extract
Superficial integumentary musculature can be loosened, there is antiwrinkle active.
Argireline is similar to creotoxin, and it can smooth or reduce the expression as caused by shrinking facial muscles expression
The position that the expression muscle such as line, especially eye circumference, forehead and the corners of the mouth is concentrated.In myoneural, shape between vesica and presynaptic membrane
Into SNARE compounds, make vesica release neurotransmitters, cause contraction of muscle.In this process, Protein S NAP-25 is served
Central role, Argireline can compete SNAP-25 action site, prevent SNARE compounds from being formed, prevent vesica from having
Effect release mediator, so as to reduce contraction of muscle, improves expression line.
Lysine is the synthesis indispensable composition of body protein, and lysine and arginine promote the matrix components such as collagen
Synthesis, so as to have the function that anti-aging.
After Chinese prickly ash berry extract, Argireline, lysine and arginine compounding use, Synergistic, from neurology
Play a part of anti-aging with biochemical angle, be obviously improved anti-wrinkle effect.
Polysorbate -20 is used as solubilizer, increases the dissolubility of Chinese prickly ash berry extract.
More preferably, the anti-apolexis composition also includes acetyl group tetrapeptide -5, the weight of the acetyl group tetrapeptide -5
Amount number is 30-40 parts.
Using above-mentioned technical proposal, acetyl group tetrapeptide -5 can effectively suppress angiotensin converting enzyme (ACE) work
Property, eye circumference vessel retraction is reduced, is stimulated circulation, so as to improve livid ring around eye；Lift the work of superoxide dismutase (SOD)
Property, strengthen the Scavenging activity of free radical, protect collagen molecules, mitigate the pouch for being saccharified by collagen, accumulating and being formed；
In addition, acetyl group tetrapeptide -5 can also reduce the permeability of blood vessel, excessively oozing out for the materials such as moisture, ocular edema of releiving are reduced
Phenomenon.
Acetyl group tetrapeptide -5 and Chinese prickly ash berry extract, Argireline, lysine, arginine compounding use, collaboration increase
Effect, further lift anti-wrinkle effect.
More preferably, the anti-apolexis composition also includes Matrixyl -4, the weight of the Matrixyl -4
Amount number is 15-20 parts.
Using above-mentioned technical proposal, Matrixyl -4 is I-type collagen precursor sequence fragment, and its energy intense stimulus is thin
Fibroblastic growth in extracellular matrix (ECM), so as to stimulate I and type III collagen and fibrin and hyalomitome
The synthesis of acid.As signal peptide, it significantly stimulates collagen in dermal layer of the skin to generate, shown particular for deep wrinkles effect
Write.During skin ageing, the loss of the material such as collagen and hyaluronic acid causes skin to become more fragile, relaxation.
Matrixyl -4 can significantly improve the contents level of NTx albumen in skin, while promote fibronectin and hyaluronic acid
Synthesis, effectively keep skin normal configuration, can also increase skin moisturizing power, delaying skin aging.
It has been investigated that Matrixyl -4 and acetyl group tetrapeptide -5, Chinese prickly ash berry extract, Argireline, bad ammonia
Acid, arginine compounding use, Synergistic, further lift anti-wrinkle effect.
More preferably, the anti-apolexis composition includes the component of following parts by weight：
2 parts of Chinese prickly ash berry extract；
- 204 parts of polysorbate；
50 parts of amino acid；
30 parts of Argireline；
- 530 parts of acetyl group tetrapeptide；
- 415 parts of Matrixyl；
Wherein amino acid is the mixture of arginine and lysine arbitrary proportion.
The purpose of the present invention two is to provide a kind of preparation method of the anti-apolexis composition as described in purpose one, using this
Anti-apolexis composition prepared by method has the advantages of repairing skin, anti-wrinkle, anti-aging.
To achieve the above object two, the invention provides following technical scheme：
A kind of preparation method of anti-apolexis composition as described in purpose one, by the Chinese prickly ash berry extract of corresponding parts by weight, gather
Sorbitol ester -20, Argireline, acetyl group tetrapeptide -5, Matrixyl -4, arginine and lysine are below 45 DEG C
Under the conditions of be mixed evenly, obtain anti-apolexis composition.
Using above-mentioned technical proposal, each component raw material is mixed at a lower temperature, is ensureing that each component dissolving mixing is equal
On the premise of even, the volatilization of Chinese prickly ash berry extract and polypeptide inactivation can be avoided.
The purpose of the present invention three is to provide a kind of application of anti-apolexis composition as described in purpose one on cosmetics.
A kind of application of anti-apolexis composition as described in purpose one on cosmetics, the cosmetics include facial mask, eye
Film, Essence, skin care condensation, face cream, emulsion.
More preferably, the cosmetics include 10-25% anti-apolexis composition by weight percentage.
In summary, the invention has the advantages that：
(1) Chinese prickly ash berry extract loosens superficial integumentary musculature from the angle of neurology, reaches the effect that lifting is compacted, lysine
Promote the synthesis of the matrix components such as collagen from biochemical angle with arginine, so as to reach the effect of anti-aging,
Argireline reduces contraction of muscle, improves expression line, four compounding use Synergistics, lifts anti-wrinkle effect；
(2) it can be stimulated circulation by adding acetyl group tetrapeptide -5, so as to improve livid ring around eye, lift superoxide dismutase
(SOD) activity, strengthen the Scavenging activity of free radical, protect collagen molecules；
(3) by adding Matrixyl -4, the synthesis of I and type III collagen and fibrin and hyaluronic acid is stimulated,
Skin normal configuration is effectively kept, can also increase skin moisturizing power, delaying skin aging；
(4) compared with injecting creotoxin smoothing wrinkle in the prior art, the anti-apolexis composition in the present invention will not produce side effect, pacify
Full property is higher.
Brief description of the drawings
Fig. 1 is the process chart of the present invention.
Embodiment
With reference to the accompanying drawings and examples, the present invention will be described in detail.
Embodiment 1：As shown in figure 1, a kind of anti-apolexis composition, each component and its corresponding parts by weight are as shown in table 1,
And acquisition is made by the steps：Each component in formula is weighed, by Chinese prickly ash berry extract, the polysorbate of corresponding parts by weight
Under conditions of ester -20, Argireline, acetyl group tetrapeptide -5, Matrixyl -4, arginine and lysine are below 45 DEG C
It is mixed evenly, obtains anti-apolexis composition, wherein, the ratio of weight and number of arginine and lysine is 1:1.
Embodiment 2-12：A kind of anti-apolexis composition, it is with the difference of embodiment 1, each component and its corresponding
Parts by weight are as shown in table 1.
Each component and its parts by weight in the embodiment 1-12 of table 1
Eye cream matrix：It is made up of the composition of following parts by weight：10 parts of olive oil, 5 parts of vitamin E, 5 parts of soybean lecithin and go
80 parts of ionized water.
Comparative example 1：A kind of anti-apolexis composition, implement in the Chinese invention patent using Publication No. CN106265120A
The method of example 1 prepares Oligopeptide Compositions, takes 5 parts of Oligopeptide Compositions to add in 95 parts of above-mentioned eye cream matrix.
Comparative example 2：A kind of anti-apolexis composition, 5 parts of Chinese prickly ash berry extracts are taken to add in 95 parts of above-mentioned eye cream matrix.
Comparative example 3：A kind of anti-apolexis composition, 40 parts of Argirelines are taken to add in 60 parts of above-mentioned eye cream matrix.
Comparative example 4：A kind of anti-apolexis composition, take 40 parts of amino acid (arginine：Lysine=1:1) 60 parts of addition is above-mentioned
Eye cream matrix in.
Comparative example 5：A kind of anti-apolexis composition, 30 parts of acetyl group tetrapeptides -5 are taken to add in 70 parts of above-mentioned eye cream matrix.
Comparative example 6：A kind of anti-apolexis composition, 15 parts of Matrixyls -4 are taken to add in 85 parts of above-mentioned eye cream matrix.
Comparative example 7：A kind of anti-apolexis composition, it is with the difference of embodiment 1, is made by the steps and obtains
：Weigh formula in each component, by the Chinese prickly ash berry extract of corresponding parts by weight, polysorbate -20, Argireline,
Acetyl group tetrapeptide -5, Matrixyl -4, arginine and lysine below 60 DEG C under conditions of be mixed evenly, resisted
Anti-aging composition, wherein, the ratio of weight and number of arginine and lysine is 1:1.
Test anti-wrinkle experiment
Test specimen：The anti-apolexis composition 80 parts of above-mentioned eye cream matrix of each 20 parts of additions obtained respectively in Example 1-12
It is middle to be used as test specimen 1-12, using the anti-apolexis composition obtained in comparative example 1-7 as control sample 1-7.
Test method：The healthy population case 190 for randomly selecting 30-40 year of areal is used as volunteer, aspiration
Person without serious systemic disease, without immune deficiency or autoimmune disease, no active anaphylactia, to skin-care cosmetics
Without severe allergy history, it is nearly 1 month in using hormone medicine or immunodepressant, do not participate in other clinical tests, be not coated with
The external preparations such as any cosmetics are smeared, the eye circumference skin of volunteer has the symptoms such as microgroove or wrinkle, is randomly divided into 19 groups, often
10 people of group.
1.1 skin mean roughness
Anti-wrinkle efficacy assessments are carried out using wrinkle of skin tester SV600, the wrinkle of skin of institute's measurement site is first replicated with silicon mould
Model, computer carry out grade separation and statistical disposition according to wrinkle of skin depth.Calculate sample use before, the skin after use
Mean roughness R3 is (i.e.：Arithmetic mean number is taken to the R1 values measured by 5 equal lengths, different segment, wherein R1 is represented one
The distance between peak value and minimum in measured length, μm).As a result with Δ R3 (i.e.：Using before sample with using the skin after sample
The difference of mean roughness) represent, numerical value is higher, and it is better to represent effect improving wrinkles.
1.2 smoothing wrinkles are tested
1-19 groups volunteer uses test specimen 1-12 and control sample 1-7, application method respectively：After cleaning eye, smear
In eye circumference, once in the morning and once at night.Record before subject uses and using the eye circumference wrinkle quantity and the number of depth after one month
According to the reduction percentage of calculating wrinkle quantity and depth, every group is averaged.
Result of the test：The skin mean roughness and smoothing wrinkle test result of 1-19 group volunteers is as shown in table 2.By table 2
Understand, after Chinese prickly ash berry extract, Argireline, lysine and arginine compounding use, Synergistic, from neurology and life
Play a part of anti-aging in the angle of thing chemistry, anti-wrinkle effect is obviously improved, particularly with the addition of acetyl group tetrapeptide -5 and palm
After acyl pentapeptide -4, six Synergistics, anti-wrinkle effect is further lifted.
The skin mean roughness and smoothing wrinkle test result of the 1-19 group volunteers of table 2
Test two irritation tests
Test specimen：Using the anti-apolexis composition obtained in embodiment 1-12, each 20 parts add in 80 parts of eye cream matrix as examination
Sample 1-12 is tested, using the anti-apolexis composition obtained in comparative example 1-7 as control sample 1-7.
Test method：Using《Cosmetics safety technical specification》Version chapter 7 Section 2 human skin patch in 2015
Specified in method, test specimen 1-12 control samples 1-7 is tested, observation smear specimen locations dermoreaction, by skin
Skin reaction grade scale record result.
Result of the test：Test specimen 1-12 and control sample 1-7 excitant test result is as shown in table 3.Can by table 3
Know, test specimen 1-12 and control sample 2-7 grading system is 0, skin irritatin intensity be it is nonirritant, control sample 1
Grading system is 1, and skin irritatin intensity is minimal irritation, illustrates that the anti-apolexis composition in the application is stingless to human body skin
Swash effect.
The test specimen 1-12 of table 3 and control sample 1-7 excitant test result
| Sample number into spectrum | Grading system |
| Test specimen 1 | 0 |
| Test specimen 2 | 0 |
| Test specimen 3 | 0 |
| Test specimen 4 | 0 |
| Test specimen 5 | 0 |
| Test specimen 6 | 0 |
| Test specimen 7 | 0 |
| Test specimen 8 | 0 |
| Test specimen 9 | 0 |
| Test specimen 10 | 0 |
| Test specimen 11 | 0 |
| Test specimen 12 | 0 |
| Control sample 1 | 1 |
| Control sample 2 | 0 |
| Control sample 3 | 0 |
| Control sample 4 | 0 |
| Control sample 5 | 0 |
| Control sample 6 | 0 |
| Control sample 7 | 0 |
Described above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-described embodiment,
All technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that for the art
For those of ordinary skill, some improvements and modifications without departing from the principles of the present invention, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. a kind of anti-apolexis composition, it is characterised in that include the component of following parts by weight：
Chinese prickly ash berry extract 1-5 parts；
The 2-6 parts of polysorbate -20；
Amino acid 40-60 parts；
Argireline 30-40 parts；
Wherein amino acid is the mixture of arginine and lysine arbitrary proportion.
2. anti-apolexis composition according to claim 1, it is characterised in that the anti-apolexis composition also includes acetyl group
Tetrapeptide -5, the parts by weight of the acetyl group tetrapeptide -5 are 30-40 parts.
3. anti-apolexis composition according to claim 2, it is characterised in that the anti-apolexis composition also includes palmityl
Pentapeptide -4, the parts by weight of the Matrixyl -4 are 15-20 parts.
4. anti-apolexis composition according to claim 3, it is characterised in that the anti-apolexis composition includes following weight
The component of number：
2 parts of Chinese prickly ash berry extract；
4 parts of polysorbate -20；
50 parts of amino acid；
30 parts of Argireline；
30 parts of acetyl group tetrapeptide -5；
15 parts of Matrixyl -4；
Wherein amino acid is the mixture of arginine and lysine arbitrary proportion.
5. a kind of preparation method of anti-apolexis composition as claimed in claim 3, it is characterised in that by corresponding parts by weight
Chinese prickly ash berry extract, polysorbate -20, Argireline, acetyl group tetrapeptide -5, Matrixyl -4, arginine and rely
Propylhomoserin below 45 DEG C under conditions of be mixed evenly, obtain anti-apolexis composition.
A kind of 6. application of the anti-apolexis composition on cosmetics as claimed in claim 3, it is characterised in that the cosmetics
Including facial mask, eye mask, Essence, skin care condensation, face cream, emulsion.
7. application according to claim 6, it is characterised in that the cosmetics include 10-25%'s by weight percentage
Anti-apolexis composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711153833.1A CN107854355A (en) | 2017-11-18 | 2017-11-18 | A kind of anti-apolexis composition and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711153833.1A CN107854355A (en) | 2017-11-18 | 2017-11-18 | A kind of anti-apolexis composition and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107854355A true CN107854355A (en) | 2018-03-30 |
Family
ID=61703105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711153833.1A Pending CN107854355A (en) | 2017-11-18 | 2017-11-18 | A kind of anti-apolexis composition and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107854355A (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379110A (en) * | 2018-05-16 | 2018-08-10 | 广州莎利曼尔生物科技有限公司 | Skin care compositions, skin care cream and preparation method thereof |
| CN108524478A (en) * | 2018-06-11 | 2018-09-14 | 四川大学华西医院 | Purposes of the sanshool in preparing the external preparation for repairing dermal photodamage |
| CN108904317A (en) * | 2018-06-13 | 2018-11-30 | 浙江湃肽生物有限公司 | A kind of polypeptides in combination method of anti-wrinkle |
| CN109864912A (en) * | 2019-04-02 | 2019-06-11 | 云南菌沃生物技术有限公司 | A kind of natural pine needle skin repair Essence and its preparation process |
| CN110403845A (en) * | 2019-09-11 | 2019-11-05 | 杨立敏 | A kind of face cream and skin care item suit |
| CN110721106A (en) * | 2019-11-08 | 2020-01-24 | 重庆创园生物科技有限公司 | Skin-activating facial mask and preparation process thereof |
| CN111631989A (en) * | 2020-07-24 | 2020-09-08 | 泉后(广州)生物科技研究院有限公司 | Anti-wrinkle composition and preparation method and application thereof |
| CN112915059A (en) * | 2021-02-03 | 2021-06-08 | 东阿阿胶股份有限公司 | Moisture-retaining flaky microcapsule containing donkey-hide gelatin and preparation method |
| CN113842334A (en) * | 2021-10-13 | 2021-12-28 | 上海起绗科技有限公司 | Composition for promoting skin multi-dimensional defense and repair and preparation method thereof |
| CN114099634A (en) * | 2020-08-26 | 2022-03-01 | C·扎维拉 | Composition and method for reducing skin wrinkles in a subject |
| CN114376932A (en) * | 2022-02-25 | 2022-04-22 | 山东花物堂生物科技有限公司 | Composition for improving stimulation of gamma-aminobutyric acid and preparation method and application thereof |
| CN114848532A (en) * | 2022-05-24 | 2022-08-05 | 珀莱雅化妆品股份有限公司 | A composition rich in biotin and guanosine for cosmetics and its preparation method |
| CN114886792A (en) * | 2022-06-30 | 2022-08-12 | 水羊化妆品制造有限公司 | Wrinkle-removing composition, preparation method and application thereof |
| CN114917139A (en) * | 2022-05-09 | 2022-08-19 | 珀莱雅化妆品股份有限公司 | Composite acetyl hexapeptide-1 and transdermal preparation and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102325567A (en) * | 2009-02-23 | 2012-01-18 | 因德纳有限公司 | Cosmetic wrinkel treatment method based on zanthoxylum bungeanum extract |
| CN103619211A (en) * | 2011-06-27 | 2014-03-05 | 株式会社爱茉莉太平洋 | Skin care kit comprising cosmetic compound and application method for the cosmetic compound |
| CN104473856A (en) * | 2014-11-24 | 2015-04-01 | 北京美颜生物科技有限公司 | Moistening and repairing facial mask and preparation method thereof |
| FR3048611A1 (en) * | 2016-03-14 | 2017-09-15 | Laboratoire Garancia | ASSOCIATION OF ZANTHOXYLUM BUNGEANUM, BENTONITE, AND ACETYL HEXAPEPTIDE 8 FOR IMPROVING THE APPEARANCE OF THE SKIN. |
-
2017
- 2017-11-18 CN CN201711153833.1A patent/CN107854355A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102325567A (en) * | 2009-02-23 | 2012-01-18 | 因德纳有限公司 | Cosmetic wrinkel treatment method based on zanthoxylum bungeanum extract |
| CN103619211A (en) * | 2011-06-27 | 2014-03-05 | 株式会社爱茉莉太平洋 | Skin care kit comprising cosmetic compound and application method for the cosmetic compound |
| CN104473856A (en) * | 2014-11-24 | 2015-04-01 | 北京美颜生物科技有限公司 | Moistening and repairing facial mask and preparation method thereof |
| FR3048611A1 (en) * | 2016-03-14 | 2017-09-15 | Laboratoire Garancia | ASSOCIATION OF ZANTHOXYLUM BUNGEANUM, BENTONITE, AND ACETYL HEXAPEPTIDE 8 FOR IMPROVING THE APPEARANCE OF THE SKIN. |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379110B (en) * | 2018-05-16 | 2021-03-16 | 广州莎利曼尔生物科技有限公司 | Skin care composition, skin care cream and preparation method thereof |
| CN108379110A (en) * | 2018-05-16 | 2018-08-10 | 广州莎利曼尔生物科技有限公司 | Skin care compositions, skin care cream and preparation method thereof |
| CN108524478A (en) * | 2018-06-11 | 2018-09-14 | 四川大学华西医院 | Purposes of the sanshool in preparing the external preparation for repairing dermal photodamage |
| CN108524478B (en) * | 2018-06-11 | 2020-05-08 | 四川昇嘉科技有限公司 | Application of sanshool in preparation of external preparation for repairing skin photodamage |
| CN108904317A (en) * | 2018-06-13 | 2018-11-30 | 浙江湃肽生物有限公司 | A kind of polypeptides in combination method of anti-wrinkle |
| CN109864912A (en) * | 2019-04-02 | 2019-06-11 | 云南菌沃生物技术有限公司 | A kind of natural pine needle skin repair Essence and its preparation process |
| CN110403845A (en) * | 2019-09-11 | 2019-11-05 | 杨立敏 | A kind of face cream and skin care item suit |
| CN110721106A (en) * | 2019-11-08 | 2020-01-24 | 重庆创园生物科技有限公司 | Skin-activating facial mask and preparation process thereof |
| CN111631989B (en) * | 2020-07-24 | 2022-10-11 | 泉后(广州)生物科技研究院有限公司 | Anti-wrinkle composition and preparation method and application thereof |
| CN111631989A (en) * | 2020-07-24 | 2020-09-08 | 泉后(广州)生物科技研究院有限公司 | Anti-wrinkle composition and preparation method and application thereof |
| CN114099634A (en) * | 2020-08-26 | 2022-03-01 | C·扎维拉 | Composition and method for reducing skin wrinkles in a subject |
| CN112915059A (en) * | 2021-02-03 | 2021-06-08 | 东阿阿胶股份有限公司 | Moisture-retaining flaky microcapsule containing donkey-hide gelatin and preparation method |
| CN113842334A (en) * | 2021-10-13 | 2021-12-28 | 上海起绗科技有限公司 | Composition for promoting skin multi-dimensional defense and repair and preparation method thereof |
| CN113842334B (en) * | 2021-10-13 | 2023-03-10 | 上海起绗科技有限公司 | Composition for promoting skin multi-dimensional defense and repair and preparation method thereof |
| CN114376932A (en) * | 2022-02-25 | 2022-04-22 | 山东花物堂生物科技有限公司 | Composition for improving stimulation of gamma-aminobutyric acid and preparation method and application thereof |
| CN114376932B (en) * | 2022-02-25 | 2024-04-16 | 山东花物堂生物科技有限公司 | Composition for improving gamma-aminobutyric acid irritation as well as preparation method and application thereof |
| CN114917139A (en) * | 2022-05-09 | 2022-08-19 | 珀莱雅化妆品股份有限公司 | Composite acetyl hexapeptide-1 and transdermal preparation and application thereof |
| CN114917139B (en) * | 2022-05-09 | 2023-10-13 | 珀莱雅化妆品股份有限公司 | Compound acetyl hexapeptide-1, transdermal preparation and application thereof |
| CN114848532A (en) * | 2022-05-24 | 2022-08-05 | 珀莱雅化妆品股份有限公司 | A composition rich in biotin and guanosine for cosmetics and its preparation method |
| CN114848532B (en) * | 2022-05-24 | 2023-11-24 | 珀莱雅化妆品股份有限公司 | A composition rich in biotin and guanosine for cosmetic use and its preparation method |
| CN114886792A (en) * | 2022-06-30 | 2022-08-12 | 水羊化妆品制造有限公司 | Wrinkle-removing composition, preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107854355A (en) | A kind of anti-apolexis composition and its preparation method and application | |
| ES2285859T3 (en) | COSMETIC OR DERMOFARMACEUTICAL USE OF PEPTIDES FOR THE CICATRIZATION, HYDRATION AND IMPROVEMENT OF THE SKIN ASPECT DURING NATURAL OR ACCELERATED AGING (HELIODERMIA, CONTAMINATION). | |
| US7300649B2 (en) | Cosmetic and cosmeceutical compositions for restoration of skin barrier function | |
| CN103315934B (en) | Composition for promoting opening of skin aquaporin and preparation method thereof | |
| CN104146925B (en) | It is a kind of with facial film for improving skin barrier function and function of delaying senility and preparation method thereof | |
| CN103209678B (en) | For improving the healthy collagen hydrolysate of human skin, hair and/or nail | |
| KR101736775B1 (en) | Cosmetic composition for improving skin wrinkle containing Rubus coreanus extract | |
| CN108495646A (en) | For treating and/or the compound of nursing skin, hair, nail and/or mucous membrane | |
| CN106038385A (en) | Cosmetic composition capable of stimulating collagen generation for wrinkle resistance | |
| CN110833514B (en) | Polypeptide freeze-dried powder and application thereof in preparation of anti-aging cosmetics | |
| CN108379110B (en) | Skin care composition, skin care cream and preparation method thereof | |
| CN111631989A (en) | Anti-wrinkle composition and preparation method and application thereof | |
| CN108618986A (en) | A kind of moisturizing anti-wrinkle Multifunctional mask liquid and preparation method thereof | |
| CN105616187A (en) | Smearing type intradermal injection capable of directly reaching dermis layer and preparation method thereof | |
| JP2011510908A (en) | Use of an effective agent for stimulating the expression of FN3K and / or FN3KRP for inhibiting skin aging | |
| CN102319197A (en) | Wrinkle-removal eye paste and preparation method thereof | |
| EP3773460B1 (en) | Use of a peptide for the treatment of epiderm | |
| KR20120017987A (en) | Cosmetic composition for removal the wrinkles at the corners of one's eyes | |
| CN111991319A (en) | Repair composition, preparation method and application thereof | |
| CH696659A9 (en) | Cosmetic composition for the treatment and / or prevention of skin smagllature | |
| CN108619070A (en) | A kind of ginseng moisturizing liquid and preparation method thereof | |
| CN112807417B (en) | Collagen-containing skin-whitening and anti-wrinkle medicine or cosmetic | |
| KR101232720B1 (en) | External preparation composition for removal the dead skin cell | |
| KR101650020B1 (en) | Cosmetic composition for improving skin wrinkle containing snowberry extract | |
| US20130338078A1 (en) | Skin care formulations including octapeptide complexes and methods for their manufacture |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180330 |