CN108904317A - A kind of polypeptides in combination method of anti-wrinkle - Google Patents
A kind of polypeptides in combination method of anti-wrinkle Download PDFInfo
- Publication number
- CN108904317A CN108904317A CN201810606220.7A CN201810606220A CN108904317A CN 108904317 A CN108904317 A CN 108904317A CN 201810606220 A CN201810606220 A CN 201810606220A CN 108904317 A CN108904317 A CN 108904317A
- Authority
- CN
- China
- Prior art keywords
- wrinkle
- polypeptides
- combination
- argireline
- combination method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of polypeptides in combination methods of anti-wrinkle, pass through one or more kinds of polypeptides, reach the release for preventing vesica and cell membrane fusion and inhibiting acetylcholine, including anti-wrinkle polypeptides in combination, mass concentration 0.001%-5%, moisturizer, mass concentration 0.001%-10%, antibacterial stabilizer 0.001%-2%, preservative mass concentration range 0.001%-2%, PH regulator, the anti-wrinkle polypeptides in combination includes that any one or a few in Argireline or Matrixyl -4 or class snake venom peptide or -1 copper of tripeptides combines, the anti-wrinkle polypeptides in combination mass concentration 0.001%-5%, remaining deionized water.The action target spot for the mechanism and polypeptide that the present invention is generated according to wrinkle is different, provides the peptide composition for anti-wrinkle.
Description
Technical field
The invention belongs to medical cosmetic fields, are related to a kind of polypeptides in combination for anti-wrinkle, the side compounded using polypeptide
Method can be prepared into various beauty skin care products and curable product, for promoting skin collagen to generate, glabrous skin,
The contraction of muscle cell is reduced, wrinkle is desalinated.
Background technique
Facial wrinkles increase is the important symbol of aging.The formation of wrinkle is not merely Time fleets past to generate.Wherein
Aging is that wrinkle generates most important reason.With the increase at age, spends adipose gland and sweat gland deterioration, skin tarnishes,
Become drying, subcutaneous fat is also reduced, and skin starts loose no elasticity, and here it is so-called " agings ".
In addition wrinkle is caused to generate there are also following several reasons, ultraviolet light：Sunlight is the formidable enemy of skin, or even in winter mistake
Divide to shine and arrive sunlight, ultraviolet light can also hurt skin corium, and the drying of order forms small fracture, shows that outside is then tiny wrinkle.
Weight fluctuations：Because diet or the big rise and big fall for not paying attention to keeping on a diet and causing weight, will lead to subcutaneous fat
Suddenly it reduces or increases suddenly, after skin " eating " is fat, if subtract suddenly thin in the short time again, skin will be obvious loose, generation
Wrinkle.
It is improper to maintain：Skin wrinkle can all be enabled by excessively cleaning or moistening.Middle dry skin feels tightly drawn, oiliness skin
Skin becomes more greasy, is excessive clean sign, because overweight or direction is not right, face mask film number is excessive for massage for another example, shield
Skin product cosmetics are applied with overweight, and face cleaning product, ten thousand formula of face cleaning be not reciprocity all to lead to pachylosis, wrinkle increase.
Smoking：Smoking four increases wrinkle, because the adhesive force of carbon monoxide and red blood cell in smog is eager to excel than oxygen.
After carbon monoxide is attached to erythrocyte surface, tissue, skin can be made to cause anaerobic condition.In addition, nocuousness in smog or point
Blood vessel, cutaneous blood circulation constantly are encroached on, so that skin be made to follow the string and gloss, wrinkle also occurs and increases therewith
It is more.
But whether being what reason, the molecular mechanism of skin of face aging is attributed to its collagen triple helix conformation
Change, the decomposition of elastin polypeptide class and the lipid arrangement disorder being filled in skin etc..However these phenomenons can pass through
It adjusts contraction of muscle and avoids.
Summary of the invention
In view of the deficiencies of the prior art, the present invention is by the way of active peptides compounding, by adjusting contraction of muscle and rush
Into the generation of skin collagen, can effectively prevent to keep skin tight with desalination wrinkle, the generation of promotion dermal matrix albumen
It causes, high resilience is full, smooth.
To achieve the above object, the present invention provides following technical solutions：
By one or more kinds of polypeptides, reach the release for preventing vesica and cell membrane fusion and inhibiting acetylcholine, including dispel
Wrinkle polypeptides in combination, mass concentration 0.001%-5%, moisturizer, mass concentration 0.001%-10%, antibacterial stabilizer 0.001%-2%,
Preservative mass concentration range 0.001%-2%, PH regulator, the anti-wrinkle polypeptides in combination include Argireline or palmityl
Any one or a few in pentapeptide -4 or class snake venom peptide or -1 copper of tripeptides combines, the anti-wrinkle polypeptides in combination mass concentration
0.001%-5%, remaining deionized water.
Preferably, the anti-wrinkle polypeptides in combination includes Argireline, class snake venom peptide, Matrixyl -4.
Preferably, the anti-wrinkle polypeptides in combination includes Argireline, class snake venom peptide, -1 copper of tripeptides.
Preferably, the anti-wrinkle polypeptides in combination includes Argireline, Matrixyl -4, -1 copper of tripeptides.
Preferably, the anti-wrinkle polypeptides in combination includes Argireline, class snake venom peptide, Matrixyl -4, tripeptides -1
Copper.
Preferably, the moisturizer includes hyaluronic acid, Aloe Vera Gel, any one or a few in glycerol.
Preferably, the PH regulator includes sodium bicarbonate, triethanolamine, hydrochloric acid, adjusting PH range 3-7.
Preferably, the antibacterial stabilizer selects 1.2- hexylene glycol.
Preferably, the preservative selects Sensiva SC50.
Preferably, the anti-wrinkle polypeptides in combination is used for face cream, Essence, facial mask, emulsion, creme, gel.
Preferably, the anti-wrinkle polypeptides in combination product is used for anti-wrinkle face mask, anti-wrinkle essence, crease-resistant face cream, medical dressing.
Preferably, the anti-wrinkle polypeptides in combination product is mainly for the preparation of external preparation for skin skin care item, curable product.
In summary：
Argireline is the N-terminal analogies of nerve connection Protein S NAP25, therefore can be formed with SNAP25 competitive binding
Snare protein complex, the SNARE that normal SNAP25 is combined causes release of the acetylcholine between nerve synapse, so that refreshing
It is carried out through transmitting, Argireline, which combines, will lead to that SNARE complex is unstable, to influence releasing for neurotransmitter
It puts, also counteracts contraction of muscle, to reach the formation of pre- anti-wrinkle and microgroove.Simultaneously because Argireline do not need into
The injection of row subdermal muscle, has safer characteristic.
Class snake venom peptide is for muscle nAChRs acetylcholinergic receptor（mnACHR）Resist object short of money, simulate Webster armor Pallas pit viper
The mechanism of action of polypeptide moiety-waglerin1 in the venom of snake causes muscle cell membrane example logical by short of money to resisting for ACHR
The closing in road, sodium ion cannot be introduced into muscle cell and muscle made to keep relaxation state.I.e. nerve impulse signal can not be transmitted to
Muscle and lead to loosening for expression muscle.
- 1 copper of tripeptides is the tripeptides in a kind of naturally occurring human body, with the activity in various biological, including：Wound is cured
Function is closed, immunocyte is attracted, anti-oxidant, anti-inflammatory effect stimulates the synthesis of collagen and mucopolysaccharide in fibroblast, promotees
Into angiogenic growth.
Matrixyl -4 is the carbon powder end fragment of peptide former before I-type collagen.It can promote the expression of I-type collagen
With increase fibroblast extracellular matrix yield.
Detailed description of the invention
Fig. 1 be the polypeptides in combination method of anti-wrinkle of the present invention product use after muscle cell contraction comparative test column in three days
Shape figure；
Fig. 2 is that the product of the polypeptides in combination method of anti-wrinkle of the present invention uses the comparative test histogram of wrinkle decrease rate after a week；
The wrinkle decrease rate comparative test column of second week after when Fig. 3 is the product of the polypeptides in combination method of anti-wrinkle of the present invention
Figure.
Specific embodiment
A kind of embodiment of the polypeptides in combination method of anti-wrinkle of the present invention is described further.
Example one
Prescription（1 kilogram of Essence）
| Title | Content |
| Argireline | 0.5g |
| Class snake venom peptide | 0.2g |
| Matrixyl -4 | 0.1g |
| Aloe Vera Gel | 1% |
| Glycerol | 15% |
| Deionized water | 83.45% |
| Sensiva SC50 | 0.5% |
| 1.2- hexylene glycol | 1% |
| Triethanolamine | 0.05% |
Configuration method
By glycerol, Aloe Vera Gel, deionized water, Sensiva SC50,1.2- hexylene glycol stirred evenly, and Argireline is added,
Class snake venom peptide, Matrixyl -4 stir evenly, temperature control at 25 degree or so, be added triethanolamine adjust pH value be 4.5-6.5 it
Between.
Example two
Prescription（1 kilogram of Essence）
| Title | Content |
| Argireline | 0.5g |
| Class snake venom peptide | 0.2g |
| - 1 copper of tripeptides | 0.5g |
| Aloe Vera Gel | 1% |
| Glycerol | 15% |
| Deionized water | 83.45% |
| Sensiva SC50 | 0.5% |
| 1.2- hexylene glycol | 1% |
| Triethanolamine | 0.05% |
Configuration method
By glycerol, Aloe Vera Gel, deionized water, Sensiva SC50,1.2- hexylene glycol stirred evenly, and Argireline is added,
Class snake venom peptide, -1 copper of tripeptides, stirs evenly, and temperature control is added triethanolamine and adjusts pH value between 4.5-6.5 at 25 degree or so.
Example three
Prescription（1 kilogram of Essence）
| Title | Content |
| Argireline | 0.5g |
| - 1 copper of tripeptides | 0.5g |
| Matrixyl -4 | 0.06g |
| Aloe Vera Gel | 1% |
| Glycerol | 15% |
| Deionized water | 83.45% |
| Sensiva SC50 | 0.5% |
| 1.2- hexylene glycol | 1% |
| Triethanolamine | 0.05% |
Configuration method
By glycerol, Aloe Vera Gel, deionized water, Sensiva SC50,1.2- hexylene glycol stirred evenly, and Argireline is added,
- 1 copper of tripeptides, Matrixyl -4 stir evenly, and temperature control is at 25 degree or so.Be added triethanolamine adjust pH value be 4.5-6.5 it
Between.
Example four
Prescription（1 kilogram of Essence）
| Title | Content |
| Argireline | 0.5g |
| Class snake venom peptide | 0.2g |
| Matrixyl -4 | 0.06g |
| - 1 copper of tripeptides | 0.5g |
| Aloe Vera Gel | 1% |
| Glycerol | 15% |
| Deionized water | 83.45% |
| Sensiva SC50 | 0.5% |
| 1.2- hexylene glycol | 1% |
| Triethanolamine | 0.05% |
Configuration method
By glycerol, Aloe Vera Gel, deionized water, Sensiva SC50,1.2- hexylene glycol stirred evenly, and Argireline is added,
Class snake venom peptide, Matrixyl -4, -1 copper of tripeptides stir evenly, and temperature control is at 25 degree or so.Triethanolamine adjusting pH value, which is added, is
Between 4.5-6.5.
Comparison example one
Prescription（1 kilogram of Essence）
| Title | Content |
| Argireline | 1g |
| Aloe Vera Gel | 1% |
| Glycerol | 15% |
| Deionized water | 83.45% |
| Sensiva SC50 | 0.5% |
| 1.2- hexylene glycol | 1% |
| Triethanolamine | 0.05% |
Configuration method
By glycerol, Aloe Vera Gel, deionized water, Sensiva SC50,1.2- hexylene glycol stirred evenly, and Argireline is added,
It stirs evenly, temperature control is at 25 degree or so.Triethanolamine is added and adjusts pH value between 4.5-6.5.
The test of five muscle cell contraction of example
Muscle cell contraction experiment, horizontal experiment embodiment one, example two, example three, reality are carried out using neuromuscular cell model
Example four, comparison example one continue three days detection muscle cell contraction rates, and data show multiple polypeptides in combination better than single polypeptide.
Six skin experiment of example
120 volunteers are chosen, the age, every group of 20 people made a skin test between 35-50 years old, and six groups twice a day make respectively
With example one, example two, example three, example four, siloxanes continuous two weeks, is coated in volunteer's test area by comparison example one
Skin surface is fabricated to the reversed duplication silicon diaphragm to match with human skin lines, analyzes silicon using laser scanning microscope
Lines on diaphragm.
Data show that 100% subjects skin's wrinkle depth is reduced, and four wrinkle depth of example reduces the most obvious.
Combined when upper content specifically repair select embodiment further detailed description of the invention, and it cannot be said that this
The specific implementation of invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, not
Under the premise of being detached from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to guarantor of the invention
Protect range.
Claims (10)
1. a kind of polypeptides in combination method of anti-wrinkle, is primarily characterized in that：By one or more kinds of polypeptides, reach prevention vesica
Inhibit the release of acetylcholine, including anti-wrinkle polypeptides in combination, mass concentration 0.001%-5%, moisturizer, matter with cell membrane fusion
Measure concentration 0.001%-10%, antibacterial stabilizer 0.001%-2%, preservative mass concentration range 0.001%-2%, PH regulator, institute
State anti-wrinkle polypeptides in combination include any one in Argireline or Matrixyl -4 or class snake venom peptide or -1 copper of tripeptides or
Several combinations, the anti-wrinkle polypeptides in combination mass concentration 0.001%-5%, remaining deionized water.
2. a kind of polypeptides in combination method of anti-wrinkle according to claim 1, it is characterised in that：The anti-wrinkle polypeptides in combination includes
Argireline, class snake venom peptide, Matrixyl -4.
3. a kind of polypeptides in combination method of anti-wrinkle according to claim 1, it is characterised in that：The anti-wrinkle polypeptides in combination includes
Argireline, class snake venom peptide, -1 copper of tripeptides.
4. a kind of polypeptides in combination method of anti-wrinkle according to claim 1, it is characterised in that：The anti-wrinkle polypeptides in combination includes
Argireline, Matrixyl -4, -1 copper of tripeptides.
5. a kind of polypeptides in combination method of anti-wrinkle according to claim 1, it is characterised in that：The anti-wrinkle polypeptides in combination includes
Argireline, class snake venom peptide, Matrixyl -4, -1 copper of tripeptides.
6. a kind of polypeptides in combination method of anti-wrinkle according to claim 1, it is characterised in that：The moisturizer includes hyalomitome
Acid, Aloe Vera Gel, any one or a few in glycerol.
7. a kind of polypeptides in combination method of anti-wrinkle according to claim 1, it is characterised in that：The PH regulator includes carbonic acid
Hydrogen sodium, triethanolamine, hydrochloric acid adjust PH range 3-7.
8. a kind of polypeptides in combination method of anti-wrinkle described in any one of -6 according to claim 1, it is characterised in that：The anti-wrinkle
Polypeptides in combination is used for face cream, Essence, facial mask, emulsion, creme, gel.
9. a kind of polypeptides in combination method of anti-wrinkle described in any one of -6 according to claim 1, it is characterised in that：The anti-wrinkle
Polypeptides in combination product is used for anti-wrinkle face mask, anti-wrinkle essence, crease-resistant face cream, medical dressing.
10. a kind of polypeptides in combination method of anti-wrinkle described in any one of -6 according to claim 1, it is characterised in that：It is described to dispel
Polypeptides in combination product wrinkle mainly for the preparation of external preparation for skin skin care item, curable product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810606220.7A CN108904317A (en) | 2018-06-13 | 2018-06-13 | A kind of polypeptides in combination method of anti-wrinkle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810606220.7A CN108904317A (en) | 2018-06-13 | 2018-06-13 | A kind of polypeptides in combination method of anti-wrinkle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108904317A true CN108904317A (en) | 2018-11-30 |
Family
ID=64420531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810606220.7A Pending CN108904317A (en) | 2018-06-13 | 2018-06-13 | A kind of polypeptides in combination method of anti-wrinkle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108904317A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908024A (en) * | 2019-04-23 | 2019-06-21 | 嫦娥创新（武汉）生物科技有限公司 | A kind of crease-resistant Firm lotion containing polypeptide |
| CN110101594A (en) * | 2019-05-29 | 2019-08-09 | 广东科盈科技有限公司 | A kind of smoothing wrinkle compound and preparation method thereof, application |
| CN110115693A (en) * | 2019-05-22 | 2019-08-13 | 上海璞萃生物科技有限公司 | A kind of supermolecule peptide composition and preparation method thereof for anti-ageing anti-wrinkle |
| CN110859780A (en) * | 2019-12-20 | 2020-03-06 | 成都肌本演绎美丽科技有限公司 | Non-invasive wrinkle-removing anti-aging beauty method |
| CN111195354A (en) * | 2020-01-16 | 2020-05-26 | 广州优理氏生物科技有限公司 | Facial anti-wrinkle freeze-dried powder containing SNAP25-Htt150Q fusion gene nano-liposome and preparation method thereof |
| CN111518799A (en) * | 2020-04-29 | 2020-08-11 | 中国医学科学院整形外科医院 | Construction of pET44a-scFv1956# expression vector, primer and application thereof |
| CN112957271A (en) * | 2021-02-26 | 2021-06-15 | 山东科思达美生物科技有限公司 | Polypeptide composition for quickly removing wrinkles and resisting aging |
| CN114917139A (en) * | 2022-05-09 | 2022-08-19 | 珀莱雅化妆品股份有限公司 | Composite acetyl hexapeptide-1 and transdermal preparation and application thereof |
| CN116172894A (en) * | 2022-01-25 | 2023-05-30 | 上海中翊日化有限公司 | Hexapeptide-9 cyclic peptide for resisting dynamic skin wrinkles and composition thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038351A (en) * | 2016-07-12 | 2016-10-26 | 深圳市维琪医药研发有限公司 | Polypeptide composition for smoothing wrinkles |
| CN106265120A (en) * | 2016-09-12 | 2017-01-04 | 珠海金肽生物科技有限公司 | Cytokine-like effect of a kind of nine Oligopeptide Compositions and cosmetic applications |
| CN107854355A (en) * | 2017-11-18 | 2018-03-30 | 上海煓梅生物科技有限公司 | A kind of anti-apolexis composition and its preparation method and application |
-
2018
- 2018-06-13 CN CN201810606220.7A patent/CN108904317A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038351A (en) * | 2016-07-12 | 2016-10-26 | 深圳市维琪医药研发有限公司 | Polypeptide composition for smoothing wrinkles |
| CN106265120A (en) * | 2016-09-12 | 2017-01-04 | 珠海金肽生物科技有限公司 | Cytokine-like effect of a kind of nine Oligopeptide Compositions and cosmetic applications |
| CN107854355A (en) * | 2017-11-18 | 2018-03-30 | 上海煓梅生物科技有限公司 | A kind of anti-apolexis composition and its preparation method and application |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908024A (en) * | 2019-04-23 | 2019-06-21 | 嫦娥创新（武汉）生物科技有限公司 | A kind of crease-resistant Firm lotion containing polypeptide |
| CN110115693A (en) * | 2019-05-22 | 2019-08-13 | 上海璞萃生物科技有限公司 | A kind of supermolecule peptide composition and preparation method thereof for anti-ageing anti-wrinkle |
| CN110101594A (en) * | 2019-05-29 | 2019-08-09 | 广东科盈科技有限公司 | A kind of smoothing wrinkle compound and preparation method thereof, application |
| CN110859780A (en) * | 2019-12-20 | 2020-03-06 | 成都肌本演绎美丽科技有限公司 | Non-invasive wrinkle-removing anti-aging beauty method |
| CN111195354A (en) * | 2020-01-16 | 2020-05-26 | 广州优理氏生物科技有限公司 | Facial anti-wrinkle freeze-dried powder containing SNAP25-Htt150Q fusion gene nano-liposome and preparation method thereof |
| CN111518799A (en) * | 2020-04-29 | 2020-08-11 | 中国医学科学院整形外科医院 | Construction of pET44a-scFv1956# expression vector, primer and application thereof |
| CN112957271A (en) * | 2021-02-26 | 2021-06-15 | 山东科思达美生物科技有限公司 | Polypeptide composition for quickly removing wrinkles and resisting aging |
| CN116172894A (en) * | 2022-01-25 | 2023-05-30 | 上海中翊日化有限公司 | Hexapeptide-9 cyclic peptide for resisting dynamic skin wrinkles and composition thereof |
| CN114917139A (en) * | 2022-05-09 | 2022-08-19 | 珀莱雅化妆品股份有限公司 | Composite acetyl hexapeptide-1 and transdermal preparation and application thereof |
| CN114917139B (en) * | 2022-05-09 | 2023-10-13 | 珀莱雅化妆品股份有限公司 | Compound acetyl hexapeptide-1, transdermal preparation and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108904317A (en) | A kind of polypeptides in combination method of anti-wrinkle | |
| CN105125476B (en) | A kind of anti-wrinkle essence and preparation method thereof | |
| CN106038351B (en) | It is a kind of for desalinating the peptide composition of wrinkle | |
| CN102068391B (en) | Application of human steam cell growth factors in cosmetics | |
| CN108852894A (en) | It is a kind of for repairing the polypeptides in combination of whitening wrinkle-removing | |
| CN109106664A (en) | Have effects that moisturizing is releived the composition of maintenance, facial mask and preparation method thereof | |
| KR20170101946A (en) | Oleanoyl peptide composition and collagen enhancement | |
| CN104784071A (en) | Skin comprehensive anti-aging water condensation and preparation method thereof | |
| CN110123729A (en) | A kind of jelly film and preparation method thereof | |
| CN108392434A (en) | A kind of silk-extract and whitening spot-eliminating composition and preparation method containing it | |
| CN103948525A (en) | Anti-aging active composition for epidermis | |
| CN113576975A (en) | Easily-absorbed anti-aging composition and preparation method and application thereof | |
| CN113648239A (en) | Oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having anti-wrinkle repairing effect | |
| EP2744907B1 (en) | Method for producing 4-aminobutyric acid from algae | |
| CN116077369A (en) | Composition for removing wrinkles and plumping skin and preparation method and application thereof | |
| CN108524354A (en) | Skin care compositions, facial treatment mask and preparation method thereof | |
| CN109431850A (en) | A kind of application of Collagen type-I in cosmetic field | |
| KR102582633B1 (en) | Cosmetic composition for skin regeneration and wrinkle improvement containing epidermal growth factor liposomes and growth factor complex | |
| CN116143873A (en) | Active peptide and application thereof in preparation of anti-skin-aging drugs or cosmetics | |
| CN110302133A (en) | A kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract | |
| KR102377510B1 (en) | Cosmetic composition for preventing skin aging showing anti-stress effect, including hydrolyzate of Tremella fuciformis) | |
| WO2016033899A1 (en) | Dandruff removing composition for adjusting scalp oil balance | |
| CN114557909A (en) | Multiple peptide anti-wrinkle essence and preparation method thereof | |
| KR101521239B1 (en) | Cosmetic composition for anti-aging containing the extract of fermentative Scutellaria baicalensis by Laetiporus Sulphureus | |
| KR101545552B1 (en) | Cosmetic composition for whitening containing the extract of fermentative Scutellaria baicalensis by Laetiporus Sulphureus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181130 |