CN109908024A - A kind of crease-resistant Firm lotion containing polypeptide - Google Patents
A kind of crease-resistant Firm lotion containing polypeptide Download PDFInfo
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Abstract
The crease-resistant Firm lotion containing polypeptide that the invention discloses a kind of, containing mass fraction in 0.05% to 0.1% snake venom peptide, the acetyl group octapeptide -3 of the hexapeptide -11 and 0.1% to 0.2% of 0.05% to 0.15% acetyl group tetrapeptide -2,0.1% to 0.15%.Different role principle is influenced the polypeptide compounding of different metabolic access by the crease-resistant Firm lotion provided by the invention containing polypeptide, thus play the role of it is quick, be applicable in wide spectrum, that effect is lasting is crease-resistant.Based on the crease-resistant Firm lotion provided by the invention containing " goddess in the moon is compound crease-resistant " polypeptide, it is obvious to try out display anti-wrinkle effect.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, more particularly, to a kind of crease-resistant Firm lotion containing polypeptide.
Background technique
With the development of molecular biology technology, bioactivity victory peptide is proved to have various beneficial works to skin
With, the most significant effect of biologically active polypeptide is that delay skin aging, skin aging are the external manifestations of human senility, be by
In endogenous and the coefficient result of composite factors such as exogenous.With advancing age, the aging of skin is more and more obvious,
Be mainly shown as dry skin, coarse, wrinkle, tarnish, nonelastic, pale, loose, in addition occur atrophoderma, crowfoot cracks and
Senile plaque etc..
Many oligopeptides are found to have the effect of stimulation collagen hyperplasia, the effect for blocking muscular tone, inhibit improper
The effect of inflammatory reaction, thus the effect of playing crease-resistant Firm, and then be added in skin care item, claim the effect of crease-resistant Firm
Fruit.However, the addition bring effect of single polypeptide is not obvious, individual difference is larger, therefore at present containing the change of polypeptide
The apparent crease-resistant skin tightening effect that the experiment to be gone of cosmetic is claimed is difficult to obtain satisfied effect continuing and using.Therefore
The crease-resistant skin care item of the polypeptide of wide spectrum have a great market demand, however different oligopeptides dissolubility, acid-base property, molecular weight,
Absorbability etc. differs greatly, therefore how from numerous effective polypeptides, selects suitable polypeptide to form prescription, and load
It is the crease-resistant skin care item of the multiple-effect key problem to be solved in a skin care item.
Summary of the invention
Aiming at the above defects or improvement requirements of the prior art, the present invention provides a kind of, and the crease-resistant Firm containing polypeptide is newborn
Liquid, its object is to carry out selection and payload by the crease-resistant polypeptide to different efficacies, the different electrical property of different dissolubilities, from
And provide a kind of with wide spectrum, rapidly take effect and can persistently improve the multiple-effect anti-wrinkle product of wrinkle effect, it thus solves single more
Polypeptide addition absorbs and the bad technical problem of load effect during peptide additive effect is unobvious or more.
To achieve the above object, according to one aspect of the present invention, a kind of crease-resistant Firm lotion containing polypeptide is provided, is contained
There is mass fraction in 0.05% to 0.1% snake venom peptide, 0.05% to 0.15% acetyl group tetrapeptide -2,0.1% to 0.15%
Hexapeptide -11 and 0.1% to 0.2% acetyl group octapeptide -3.
Preferably, the crease-resistant Firm lotion, the also argireline containing mass fraction 0.1% to 0.2%.
Preferably, the crease-resistant Firm lotion, the also nonapeptide -1 containing mass fraction 0.15% to 0.3%.
Preferably, the crease-resistant Firm lotion, the lotion contain hydrophilic and oleophilic matrix.
Preferably, the crease-resistant Firm lotion, the hydrophilic and oleophilic matrix are oil-in-water shape nanoemulsions.
Preferably, the crease-resistant Firm lotion, the oil-in-water type nano-emulsion liquid contain 12% to 20% liquid rouge
Fat acid, 1.5% to 2.5% emulsifier and 3% to 10% of the HLB value between 8 to 10 glycerol.
Preferably, the crease-resistant Firm lotion, containing mass fraction 0.05% to 0.10% it is fat-soluble anti-oxidant
Agent, 0.05% to 0.10% water soluble antioxidant, 0.40% to 1.0% water-soluble thickener.
Preferably, the crease-resistant Firm lotion, pH value is between 7.2 to 7.8.
Other side according to the invention provides a kind of preparation method of crease-resistant Firm lotion, uses D phase
Emulsion process is made under the conditions of 18 DEG C to 30 DEG C of temperature.
Preferably, the preparation method of the crease-resistant Firm lotion comprising following steps:
(1) D phase, oily phase, water phase are prepared:
D phase: hexapeptide -11, snake venom peptide, nonapeptide -1, emulsifier, pure water and polyalcohol are mixed to form D phase according to formula rate；
The emulsifier is HLB value between 8 to 10；
Oily phase: using the liquid fat acid or liquid fat acid blend of C15 to C20 as oily phase, it is molten to preferably include oil
Property antioxidant.
Water phase: acetyl group tetrapeptide -2, acetyl group octapeptide -3, argireline, water-soluble thickener, pH adjusting agent, Yi Jichun
Water is mixed to form water phase according to formula rate；
(2) in step (1) it is obtained oil mutually be slowly added into D phase while agitating, formed gel-like emulsion；
(3) gel-like emulsion obtained in step (2) is mixed with the water phase prepared in step (1), oil-in-water type is made
Lotion, i.e., the described crease-resistant Firm lotion of polypeptide.
In general, through the invention it is contemplated above technical scheme is compared with the prior art, can obtain down and show
Beneficial effect:
Different role principle is influenced the more of different metabolic access by the crease-resistant Firm lotion provided by the invention containing polypeptide
Peptide compounding, thus play the role of it is quick, be applicable in wide spectrum, that effect is lasting is crease-resistant.
Preferred embodiment is received to maintain the not preferable stable state of homopolypeptide and Transdermal absorption effect using oil-in-water type
Rice milk, the different polypeptide of dissolubility are supported on respectively in oily phase and water phase, are aided with antioxidant, thickener and emulsifier, so that
The load balancing of polypeptide is stablized, and long-term preservation is not easily decomposed.The further pH value for adjusting nano-emulsion, makes it be coated on skin table
Face process pH value is gradually reduced, in the process, it is different electrically, deliquescent polypeptides successively Transdermal absorption, avoid competing transdermal
Channel causes compounding effect bad.Based on the crease-resistant Firm lotion provided by the invention containing " goddess in the moon is compound crease-resistant " polypeptide, try out
Show that anti-wrinkle effect is obvious.
The preparation method of crease-resistant Firm lotion provided by the invention can be obtained at a lower temperature using D phase emulsion process
To the uniform and stable nanoemulsions of particle diameter distribution, it is especially suitable for the compound crease-resistant facial treatment milk of multiple polypeptides provided by the invention.
Detailed description of the invention
Fig. 1 is 1 face-image of subject provided in an embodiment of the present invention, and wherein A figure is face-image when test starts, B
Figure is face-image at the end of test；
Fig. 2 is 2 face-image of subject provided in an embodiment of the present invention, and wherein A figure is face-image when test starts, B
Figure is face-image at the end of test；
Fig. 3 is 3 face-image of subject provided in an embodiment of the present invention, and wherein A figure is face-image when test starts, B
Figure is face-image at the end of test.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.As long as in addition, technical characteristic involved in the various embodiments of the present invention described below each other it
Between do not constitute conflict and can be combined with each other.
Crease-resistant Firm lotion provided by the invention containing polypeptide, including mass fraction 0.05% to 0.1% snake venom peptide,
The acetyl group of the hexapeptide -11 and 0.1% to 0.2% of 0.05% to 0.15% acetyl group tetrapeptide -2,0.1% to 0.15%
Octapeptide -3 preferably includes 0.1% to 0.2% argireline, 0.15% to 0.3% nonapeptide -1.
The lotion preferably comprises hydrophilic and oleophilic matrix, and the hydrophilic and oleophilic mechanism is oil-in-water type nano-emulsion liquid；It is described
Oil-in-water type nano-emulsion liquid, containing 12% to 20% liquid fat acid, 1.5% to 2.5% HLB value between 8 to 10
Emulsifier and 3% to 10% glycerol.
The lotion contain mass fraction 0.05% to 0.10% fat-soluble antioxidant, 0.05% to 0.10%
Water soluble antioxidant, 0.40% to 1.0% water-soluble thickener.Due to the present invention use nano-emulsion load it is fat-soluble and
Water-soluble crease-resistant polypeptide, thus it is fat-soluble and water soluble antioxidant meet addition, better guarantor can be played than single condition
Shield effect, the fat-soluble antioxidant preferred vitamin E；The water soluble antioxidant preferred vitamin C；The water solubility
Thickener stablizes nanoemulsions for adjusting year, and preferably trehalose, polyglutamic acid sodium and/or yellow glue are former.
The presently found polypeptide classes that may have crease-resistant firming effect are numerous, and principle is different, and the present invention passes through experiment,
The polypeptide moiety for therefrom having selected action principle different with metabolic pathway is influenced, to make to generate to act synergistically between polypeptide to avoid
Phase mutual impedance.Wherein:
Snake venom peptide, molecule are as follows: H- β-Ala-Pro-Dab-NH-Bzlx, through retardance acetylcholine in conjunction with receptor, resistance
Disconnected nervous excitation transmitting, makes of flaccid muscles, plays the role of rapidly calming down expression line in a short time；
Acetyl group tetrapeptide -2, molecule are as follows: Ac-D-Lys-L- α-Asp-L-Val-3-hydroxyphenylalanamide,
Signal peptide stimulates the synthesis of skin corium collagen (I type, type III, IV type) and elastin laminin.
Hexapeptide -11, molecule are as follows: it is related to extracellular matrix to influence emergency reaction by Phe-Val-Ala-Pro-Phe-Pro-OH
Access, stimulation collagen hyperplasia；
Acetyl group octapeptide -3, molecule are as follows: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, participate in competition
SNAP-25 is in the site for melting bubble complex, to influence the formation of complex.If melting bubble complex slightly to interfere, vesica is not
It can be released effectively neurotransmitter, cooperate with performance to cause contraction of muscle to weaken with snake venom peptide, prevent the formation of wrinkle.
Argireline, molecule are as follows: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2, leather bag nerve conduction is influenced, face is made
Portion's loosening all muscles cooperates with the effect for playing and calming down expression line in a short time with snake venom peptide；Secondly collagen elastic force can be effectively reorganized,
The activity that elastin can be increased assists the ingredient of other stimulation collagen egg hyperplasia to play a role.
Nonapeptide -1, molecule are as follows: Met-Pro- (D-Phe)-Arg- (D-trp)-Phe-Lys-Pro-Val-NH2, block black
Pigment generates, and improves skin brightness, and wrinkle is reduced from perception to be influenced.
The preparation method of crease-resistant Firm lotion provided by the invention containing polypeptide, it is preferred to use D phase emulsion process at 18 DEG C extremely
It is prepared at 30 DEG C, comprising the following steps:
(1) D phase, oily phase, water phase are prepared:
D phase: hexapeptide -11, snake venom peptide, nonapeptide -1, emulsifier, pure water and polyalcohol are mixed to form D phase according to formula rate；
The emulsifier is HLB value between 8 to 10, preferably six ethylene glycol monostearates, wool alcohol ether, in polyoxyethylene laurel ether
One or more mixing, the polyalcohol, preferably glycerine.
Oily phase: using the liquid fat acid or liquid fat acid blend of C15 to C20 as oily phase, it is molten to preferably include oil
Property antioxidant；The liquid fat acid preferably oleic acid, linoleic acid, linolenic acid, arachidonic acid, and/or isostearic acid.
Water phase: acetyl group tetrapeptide -2, acetyl group octapeptide -3, argireline, water-soluble thickener, pH adjusting agent, Yi Jichun
Water is mixed to form water phase according to formula rate；The preferred trehalose of the water-soluble thickener and/or yellow glue are former；The pH adjusting agent
Preferably citric acid, vitamin C etc..
(2) in step (1) it is obtained oil mutually be slowly added into D phase while agitating, formed gel-like emulsion (O/D
Phase)；
(3) gel-like emulsion obtained in step (2) is mixed with the water phase prepared in step (1), oil-in-water type is made
Lotion, i.e., the crease-resistant Firm lotion of polypeptide of the present invention.The lotion can cooperate in common cosmetic preparation joined together other
Ingredient, such as Water-soluble UV-absorbents, powder, finish, other water soluble polymers, envelope forming agent, alcohols, clay pit
It is substance, resin, moisturizer, preservative, antibacterial agent, fragrance, salt, antioxidant, pH adjusting agent, chelating agent, freshener, anti-inflammatory
Agent, U.S. flesh ingredient, vitamins, amino acids, nucleic acid, inclusion compound etc..
The following are embodiments:
A kind of crease-resistant Firm lotion containing polypeptide, component list are as follows:
Embodiment provide crease-resistant Firm lotion the preparation method is as follows:
(1) D phase, oily phase, water phase are prepared:
D phase constituent in formula table is stirred at 18 DEG C to 25 DEG C；
Oil-phase component in formula table is stirred at 25 DEG C to 30 DEG C；To be sufficiently mixed oil-phase component, environment temperature
Oil-phase component temperature can be improved when spending lower to mix them thoroughly；
Water-phase component in formula table is stirred at 25 DEG C to 30 DEG C；
(2) in step (1) it is obtained oil mutually be slowly added into D phase while agitating, formed gel-like emulsion (O/D
Phase)；Maintain temperature at 18 DEG C to 30 DEG C；
(3) gel-like emulsion obtained in step (2) is mixed with the water phase prepared in step (1), oil-in-water type is made
Lotion；Maintain temperature at 18 DEG C to 30 DEG C.
In formula of the invention, in order to maintain polypeptide active, by addition vitamin E and vitamin C respectively to being distributed in
The polypeptide of nanometer missible oil phase and water phase carries out anti-oxidation protection, so if temperature is higher in the preparation process of nano-emulsion, antioxygen
Agent consumption rapidly, may cause polypeptide active in finished emulsion and reduce and even fail.Therefore use D phase emulsion process, can compared with
The smaller and uniform and stable nano-emulsion of granularity, the active peptides for being suitble to stable composition of the present invention different are formed at a temperature of low.
From dissolubility, the present invention uses oil-in-water type nano-emulsion, and D phase emulsion process emulsifier phase load is fat-soluble relatively strong
Polypeptide, be distributed it is more uniform, formed nano-emulsion after polypeptide is present in the good microballoon of leakproofness, preferably ensure that more
The activity of peptide.
PH value is tested to embodiment
Using glass electrode as indicator electrode, saturated calomel electrode is reference electrode, while being inserted into prepared by real-time example 1 to 8
In nanoemulsions, pH value is directly read using pH meter；
PH value measures after being coated on skin:
It is tested using skin pH meter Skin checker MJ-120；
Contact angle determination:
Water droplet is fallen on coated face, photograph taking is formed in the water droplet state on surface, is based on measuring shape contact angle.
PH value measurement display, after being coated to skin surface, pH value can be gradually reduced nanoemulsions prepared by the present invention, from
Neutrality is down to faintly acid, and during which different electrical polypeptides will be successively absorbed by the skin, to avoid competition Transdermal absorption channel, mentions
The absorptivity of high entirety polypeptide active ingredient.Contact angle experiments show, final oil film thickness of coordinating is good, can further be maintained in
The polypeptide stability of skin surface improves the absorption of water-soluble polypeptide.
Effect assessment:
60 people of subject, in which: 35 to 40 years old 14 people of women, 35 to 40 years old 2 people of male, 40 to 45 years old 18 people of women, 40
To 45 years old 3 people of male, 45 to 50 years old 16 people of women, 45 to 50 years old 1 people of male, 50 years old or more 6 people of women；Wherein: being engaged in open air
Work 22 people, 38 people of office work.
Nano-emulsion prepared by embodiment 5 is named as the crease-resistant Firm lotion containing " goddess in the moon is compound crease-resistant " polypeptide, to all
Subject takes 2g painting to invest skin surface daily morning and evening, observes change of skin after 90 days.
Sensory evaluation: subject's self-assessment wrinkle desalinates situation, is divided into: unobvious, obvious, clearly.As a result it shows
Showing, in 60 subjects: 19 subjects think wrinkle desalination situation clearly, wherein women 18, male 1；34
Subject thinks that wrinkle desalination situation is obvious, wherein women 29, male 5；7 subjects think that wrinkle desalination is in confused situation
Aobvious, wherein 3 entitled 50 years old or more are engaged in the women of outwork, 3 are engaged in the women of office work for entitled 35 to 40 years old, and 1 is entitled
It is engaged within 45 to 50 years old the women of outwork.Think that wrinkle desalinates aobvious women in confused situation, it may be possible to due to its false expression
Line is less, and main wrinkle producing cause is that collagen is lost the caused true property wrinkle of fracture, and collagen content upgrades
Responding time to tightening effect is longer.
Instrument evaluation:
Using skin analyzer (the anti-ageing large paper edition of the goddess in the moon of anti-ageing limited liability company, the robot research and development of Wuhan goddess in the moon's medicine
Skin decodes robot), subjects skin's surface data is recorded, wrinkle and microgroove distribution situation are compared.
Wrinkle index is promoted obviously, the results show that nanoemulsions prepared by embodiment 5 have apparent anti-wrinkle effect.
7 are thought that wrinkle is desalinated in aobvious subject in confused situation, wherein 3 skin surface images such as Fig. 1 to Fig. 3 institute
Show, wherein A figure is subject's face image data when test starts, and B figure is subject's face image data at the end of test,
Middle crumple zone is sketched the contours automatically by skin analyzer, wrinkle parameter (percentage that wrinkle area accounts for full face product) data such as following table
Shown, display wrinkle depth is mitigated.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, not to
The limitation present invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should all include
Within protection scope of the present invention.
Claims (10)
1. a kind of crease-resistant Firm lotion containing polypeptide, which is characterized in that the snake venom containing mass fraction 0.05% to 0.1%
Peptide, 0.05% to 0.15% acetyl group tetrapeptide -2,0.1% to 0.15% hexapeptide -11 and 0.1% to 0.2% acetyl
Base octapeptide -3.
2. crease-resistant Firm lotion as described in claim 1, which is characterized in that also containing mass fraction 0.1% to 0.2%
Argireline.
3. crease-resistant Firm lotion as claimed in claim 2, which is characterized in that also containing mass fraction 0.15% to 0.3%
Nonapeptide -1.
4. the crease-resistant Firm lotion as described in claims 1 to 3 any one, which is characterized in that the lotion contains hydrophilic parent
Oil matrix.
5. crease-resistant Firm lotion as claimed in claim 4, which is characterized in that the hydrophilic and oleophilic matrix is oil-in-water shape nanometer
Lotion.
6. crease-resistant Firm lotion as claimed in claim 4, which is characterized in that the oil-in-water type nano-emulsion liquid contains 12%
To 20% liquid fat acid, 1.5% to 2.5% emulsifier and 3% to 10% of the HLB value between 8 to 10 it is sweet
Oil.
7. crease-resistant Firm lotion as claimed in claim 6, which is characterized in that containing mass fraction 0.05% to 0.10%
Fat-soluble antioxidant, 0.05% to 0.10% water soluble antioxidant, 0.40% to 1.0% water-soluble thickener.
8. crease-resistant Firm lotion as described in claim 1, which is characterized in that pH value is between 7.2 to 7.8.
9. the preparation method of the crease-resistant Firm lotion as described in claim 1 to 8 any one, which is characterized in that using D phase cream
Change method is made under the conditions of 18 DEG C to 30 DEG C of temperature.
10. the preparation method of crease-resistant Firm lotion as claimed in claim 9, which comprises the following steps:
(1) D phase, oily phase, water phase are prepared:
D phase: hexapeptide -11, snake venom peptide, nonapeptide -1, emulsifier, pure water and polyalcohol are mixed to form D phase according to formula rate；It is described
Emulsifier is HLB value between 8 to 10；
Oily phase: using the liquid fat acid or liquid fat acid blend of C15 to C20 as oily phase, it is anti-to preferably include oil-soluble
Oxidant.
Water phase: acetyl group tetrapeptide -2, acetyl group octapeptide -3, argireline, water-soluble thickener, pH adjusting agent and pure water are pressed
Water phase is mixed to form according to formula rate；
(2) in step (1) it is obtained oil mutually be slowly added into D phase while agitating, formed gel-like emulsion；
(3) gel-like emulsion obtained in step (2) is mixed with the water phase prepared in step (1), emulsion oil-in-water is made,
The i.e. described crease-resistant Firm lotion of polypeptide.
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| CN113662876A (en) * | 2021-08-27 | 2021-11-19 | 企点生物科技(上海)有限公司 | Polypeptide beautifying essence and preparation method thereof |
| CN117050146A (en) * | 2023-10-11 | 2023-11-14 | 杭州湃肽生化科技有限公司 | Hyaluronic acid modified cosmetic peptide, preparation method and application thereof |
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