JPH09315931A - Cosmetic material for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic material for skin excellent in skinbeautifying effect by containing an intercellular lipid and a promoting agent for synthesizing ceramide in epidermal cells and promoting dermal function. SOLUTION: This cosmetic material for skin excellent in skin-softening effect and amelioration effects for skin tension and skin creases, contains 0.001-10wt.% of two or more of intercellular lipids and 0.001-10wt.% of one or more of promoting agents for synthesizing ceramide in epidermal cells as effective ingredients. The intercellular lipids are selected from (A) ceramide or cerebroside, (B) a cholesterol or its derivative, (C) a phospholipid and (D) a fatty acid or its ester of an aliphatic chain alcohol. The promoting agents for synthesizing ceramide in epidermal cells are selected from nicotinic acid amide, nicotinyl alcohol, nicotinyl alcohol tartarate, nicotinic acid, methyl nicotinate, ethyl nicotinate and benzyl nicotinate.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin cosmetic which is characterized by containing an intercellular lipid and an epidermal cell ceramide synthesis promoting substance and which has an enhanced skin function and an excellent skin beautifying effect.

[0002]

2. Description of the Related Art Conventionally, in order to maintain healthy and beautiful skin, a hydrophilic skin moisturizer and an oily skin softener which give appropriate moisture and oil content to the skin have been applied to skin makeup. It is included in the ingredients. Glycerin, polyethylene glycol, pyrrolidone carboxylate, etc. are used as skin moisturizers, but these cause water loss in the skin because they absorb water from the stratum corneum, which is the outermost layer of the skin. However, the skin cosmetics containing a large amount of them are not always satisfactory, such as giving a feeling of strangeness such as stickiness.

Liquid paraffin, petrolatum, squalane, lanolin, synthetic ester oil and the like are used as skin softeners, and when these are also contained in skin cosmetics to the extent that they prevent water evaporation from the epidermis sufficiently, It had the drawback that it would hinder the normal metabolism of the skin. Further, when the intercellular lipid was blended, the effect was not sufficient, even though it did not have such a defect.

In view of the above-mentioned drawbacks of skin moisturizers and skin softeners, the present inventors rely only on the hydration of the epidermis by the physical action of the compounding agents or the prevention of water transpiration from the epidermis. Instead, the inventors have earnestly studied for the purpose of providing a skin cosmetic that acts on the skin to continuously enhance the water-retaining function originally possessed by the skin to maintain or restore the skin in a healthy state. As a result, a skin cosmetic containing an intercellular lipid and an epidermal cell ceramide synthesis promoter exhibits an effect that meets the purpose, and further imparts wettability, flexibility, elasticity and luster to the skin. The present invention has been completed by finding that it has a beautiful skin effect.

[0005]

That is, the present invention is
(1) A skin cosmetic comprising two or more kinds of intercellular lipids and one or more kinds of epidermal cell ceramide synthesis promoting substances, (2) the intercellular lipid being ceramide or cerebroside. ), The skin cosmetic, (3) the intercellular lipid is cholesterol or a derivative thereof, (4) the intercellular lipid, (A)
The above (1), which is a substance of any two or more groups selected from ceramide or cerebroside, (B) cholesterol or its derivative, (C) phospholipid, (D) fatty acid or its derivative (excluding cholesterol fatty acid ester) The skin cosmetic as described above, (5) the epidermal cell ceramide synthesis promoter is niacinamide, the skin cosmetic according to (1) to (4) above, (6) the epidermal cell ceramide synthesis promoter is nicotinamide, The skin cosmetic according to (1) to (4) above, which is one or more selected from nicotinyl alcohol, nicotinyl alcohol tartrate, nicotinic acid, methylnicotinic acid, ethylnicotinic acid, and benzylnicotinic acid.

The intercellular lipids used in the present invention include
Examples thereof include ceramides or cerebrosides derived from plants or animals, or synthesized by mimicking these, cholesterol or derivatives thereof such as cholesterol fatty acid esters, phospholipids, fatty acids or aliphatic chain alcohol esters thereof, and the like.

[0007]

Embodiments of the present invention will be described below in detail. The content of the intercellular lipid used in the present invention is preferably 0.001 based on the total weight of the skin cosmetic of the present invention.
10 to 10% by weight (hereinafter, simply indicated by%). If the content is less than 0.001%, the effect is not sufficient and 10%
Even if it exceeds, the effect commensurate with the increased amount cannot be expected.

Examples of the epidermal cell ceramide synthesis promoter used in the present invention include nicotinamide, nicotinyl alcohol, nicotinyl alcohol tartrate, nicotinic acid, methylnicotinic acid, ethylnicotinic acid and benzylnicotinic acid. . The present inventors have already found that these substances promote ceramide synthesis in epidermal cells (Japanese Patent Application No. 7-116367).

The content of the epidermal cell ceramide synthesis promoting substance used in the present invention is preferably 0.001 to 10% with respect to the total weight of the skin cosmetic of the present invention. If the content is less than the lower limit, the effect is not sufficient, and even if it exceeds the upper limit, the effect commensurate with the increased amount cannot be expected.

The skin cosmetics of the present invention are prepared according to a conventional method such as lotions, emulsions, creams, ointments, packs,
It can be made into a dosage form such as powders. Further, the skin cosmetic of the present invention includes a surfactant, a humectant, a ph regulator, a thickener, a bactericide, a preservative, an antioxidant, a fragrance, a pigment,
An ultraviolet absorber, a pigment and the like can be appropriately blended within the range where the object of the present invention is achieved.

[0011]

The present invention will be described in more detail with reference to the following examples. The blending amount (%) means% by weight. The skin viscoelasticity test method, the skin beautification effect test method, the skin roughness improving effect test method, and the test method for the effect of improving keratin (increasing the anti-peeling property of keratinous cells) described in Examples are as follows.

(1) Skin viscoelasticity test method Wistar hairless rats (6 weeks old, male, 1 group 5)
) Was shaved, and 0.1 g of the sample was applied to a 2 × 2 cm site on the right shoulder every day. Twenty-one days after the start of the test, Japanese Patent Publication No.
The skin viscoelasticity value was measured using the surface viscoelasticity measuring device described in Japanese Patent Publication No. 5, and the average value of the skin viscoelasticity value of each group was obtained.
In addition, the skin viscoelasticity value (arbitrary unit) displayed by the same measuring device shows a value that the skin is harder.

(2) Skin-Beauty Effect Test Method Female subjects (35 to 35) who complain of dryness, swelling, lack of gloss, etc.
Twenty people (55 years old) were allowed to take the sample twice a day (morning / evening) continuously for one month, and then evaluated for skin moisture (wetting), softness, elasticity (elasticity) and gloss improvement. The results are shown in terms of the number of respondents who answered "improved skin moisture", "improved skin flexibility", "improved skin firmness", and "improved skin luster" for each item.

(3) Skin Roughness Improvement Effect Test Method 20 middle-aged and elderly subjects having rough skin on the lower legs were tested for the effect of continuous application for 4 weeks. About 1 g of a sample was applied to the test site of the lower leg of the subject twice a day twice a day, and the skin condition before and after the start of the test was determined according to the following criteria. The lower right leg served as a control without the application of the sample. [Criteria for skin dryness] −: Normal ±: Minor dryness, no desquamation +: Dry, mild desquamation ++: Dry, moderate desquamation +++: Dry, remarkable desquamation Compare the determination results of the test site before and after the test with the control site , If the dryness of the skin is improved by two or more stages (for example, + →-,
++ → ±) is defined as “valid”, a case of improvement by 1 level is defined as “slightly valid”, and a case of no change is defined as “invalid”. The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

(4) Test method for keratin improving effect (increasing anti-peeling property of keratinocytes) Scotch tape (Nichiban Mending Tape) is adhered to the test site before and after the start of the above-mentioned rough skin improving effect test, and this is applied. The state of the keratinocytes attached to the tape when peeled off was examined in detail by a scanning electron microscope, and the peelability of the skin stratum corneum cells was classified according to the following criteria, and the keratin improving effect was obtained. [Judgment Criteria for Keratin Improvement (Enhancement of Exfoliation of Keratinocytes)] Evaluation Point 1: No scale was observed. Evaluation point 2: Small scale interspersed evaluation point 3: Small to medium scale remarkable Evaluation point 4: Large scale remarkable The judgment is that the difference between the evaluation point of the test site after continuous application for 4 weeks and that of the control site is 2 points or more. The case was defined as “valid”, the case of 1 point was defined as “slightly valid”, and the case of 0 point was defined as “invalid”. The test results are shown by the number of subjects who were “effective” and “somewhat effective”.

Example 1, Comparative Examples 1 and 2 [Skin milk] Skin milks of the present invention and for comparison having the compositions shown in Table 1 were prepared, the above test was carried out, and the results are shown in Table 2. (1) Composition

[0017]

[Table 1]

(2) Preparation method The component (A) is uniformly mixed and dissolved at about 60 ° C., and the component (B) that has been uniformly mixed and dissolved at about 60 ° C. is added and stirred, and then the mixture is heated to about 30 ° C. It was prepared by cooling. (3) Result

[0019]

[Table 2] * The skin viscoelasticity value of the application site was shown as a relative value based on the value of the unapplied site as a reference (1.0).

As can be seen from this table, the skin milk of the present invention of Example 1 showed good results in all tests as compared with the skin milks of Comparative Examples 1 and 2.

Examples 2, 3, 4 and Comparative Example 3 [Skin Cream] Skin creams of the present invention and comparative compositions having the compositions shown in Table 3 were prepared, the above tests were carried out, and the results are shown in Table 4. . (1) Composition

[0022]

[Table 3]

(2) Preparation method The component (C) is uniformly mixed and dissolved at about 80 ° C., added to the component (A) that has been uniformly mixed and dissolved at about 80 ° C. and emulsified, and then at about 50 ° C. Component (B) that was uniformly mixed and dissolved in
And cooled to about 30 ° C. to prepare. (3) Result

[0024]

[Table 4]

As can be seen from this table, the skin creams of Examples 2, 3 and 4 of the present invention showed good results in all the tests as compared with the skin cream of Comparative Example 3.

Example 5 [Essence] As the composition of Tables 5 and 6, an essence of the present invention for pre-preparation consisting of lotion and powder was prepared. (1) Composition and preparation method 1 agent: lotion

[0027]

[Table 5] ** 50% glycerin solution of hydroxylated soybean phospholipid (Nikko Chemical Co., Ltd.) Each component was mixed and dissolved to prepare a lotion. Two agents: powder

[0028]

[Table 6] Each component was dispersed and mixed to prepare a powder.

(2) Results The skin-beautifying effect test was divided into two groups (20 people in each group), and one group (Group A) was mixed with an appropriate amount of one agent and two agents when the essence of Example 5 was used. The other group (group B) was allowed to use only one lotion. As a result, in each item, the group A was evaluated better than the group B.

[0030]

EFFECTS OF THE INVENTION As described above, the skin cosmetic of the present invention enhances the skin function, and has an anti-aging effect on the skin (skin softening effect, skin amelioration improving effect, skin wrinkle improving effect, etc.). It is clear that it is excellent.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification number Internal reference number FI Technical indication location A61K 7/48 A61K 7/48 (72) Inventor Osamu Tanno 5-3, Shoucho, Odawara-shi, Kanagawa No. 28 Kanebo Co., Ltd.

Claims (6)

[Claims] 1. A skin cosmetic containing two or more types of intercellular lipids and one or more types of epidermal cell ceramide synthesis promoters. 2. The skin cosmetic according to claim 1, wherein the intercellular lipid is ceramide or cerebroside. 3. The skin cosmetic according to claim 1, wherein the intercellular lipid is cholesterol or a derivative thereof. 4. The intercellular lipid is (A) ceramide or cerebroside, (B) cholesterol or a derivative thereof,
The skin cosmetic according to claim 1, which is a substance of two or more arbitrary groups selected from (C) phospholipids, (D) fatty acids or aliphatic chain alcohol esters thereof. 5. The skin cosmetic according to any one of claims 1 to 4, wherein the epidermal cell ceramide synthesis promoter is nicotinic acid amide. 6. The epidermal cell ceramide synthesis promoter is one or more selected from nicotinamide, nicotinyl alcohol, nicotinyl alcohol tartrate, nicotinic acid, methylnicotinic acid, ethylnicotinic acid and benzylnicotinic acid. The skin cosmetic according to any one of claims 1 to 4.