CN115006274B - Water-oil biphase skin softening water added with blue copper peptide and preparation method thereof - Google Patents
Water-oil biphase skin softening water added with blue copper peptide and preparation method thereof Download PDFInfo
- Publication number
- CN115006274B CN115006274B CN202210770431.0A CN202210770431A CN115006274B CN 115006274 B CN115006274 B CN 115006274B CN 202210770431 A CN202210770431 A CN 202210770431A CN 115006274 B CN115006274 B CN 115006274B
- Authority
- CN
- China
- Prior art keywords
- water
- skin
- percent
- oil
- phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 77
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 title claims abstract description 55
- 241000530268 Lycaena heteronea Species 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000003755 preservative agent Substances 0.000 claims abstract description 16
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 15
- 230000002335 preservative effect Effects 0.000 claims abstract description 15
- 239000010949 copper Substances 0.000 claims abstract description 14
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910052802 copper Inorganic materials 0.000 claims abstract description 13
- 239000003906 humectant Substances 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 230000003750 conditioning effect Effects 0.000 claims abstract description 8
- 239000006174 pH buffer Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 21
- 238000001816 cooling Methods 0.000 claims description 19
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 16
- -1 maltooligosaccharide glucoside Chemical class 0.000 claims description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 12
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 11
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 8
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 8
- 229940101267 panthenol Drugs 0.000 claims description 8
- 239000011619 pantothenol Substances 0.000 claims description 8
- 235000020957 pantothenol Nutrition 0.000 claims description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 8
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims description 6
- YPUZOECTETYPRF-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine-2-carboxylic acid Chemical compound OC(=O)C1NCC=CN1 YPUZOECTETYPRF-UHFFFAOYSA-N 0.000 claims description 6
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 claims description 6
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims description 6
- 229930182478 glucoside Natural products 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 6
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 6
- 229940032094 squalane Drugs 0.000 claims description 6
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 5
- WZHKXNSOCOQYQX-FUAFALNISA-N (2s)-6-amino-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Chemical compound C([C@H](N)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CN=CN1 WZHKXNSOCOQYQX-FUAFALNISA-N 0.000 claims description 5
- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 claims description 5
- 229940035437 1,3-propanediol Drugs 0.000 claims description 5
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 5
- ZNXZGRMVNNHPCA-UHFFFAOYSA-N Pantetheine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS ZNXZGRMVNNHPCA-UHFFFAOYSA-N 0.000 claims description 5
- 150000001336 alkenes Chemical class 0.000 claims description 5
- 239000011575 calcium Substances 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 5
- 229960000367 inositol Drugs 0.000 claims description 5
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229940094912 palmitoyl tripeptide-5 Drugs 0.000 claims description 5
- ZNXZGRMVNNHPCA-VIFPVBQESA-N pantetheine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS ZNXZGRMVNNHPCA-VIFPVBQESA-N 0.000 claims description 5
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 5
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 5
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 5
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 4
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 4
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 claims description 4
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 4
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 4
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 4
- RGMZNZABJYWAEC-UHFFFAOYSA-N Methyltris(trimethylsiloxy)silane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C RGMZNZABJYWAEC-UHFFFAOYSA-N 0.000 claims description 4
- 235000021355 Stearic acid Nutrition 0.000 claims description 4
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 4
- 229940036350 bisabolol Drugs 0.000 claims description 4
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 4
- CILGDYPFLJJNKT-NAWJVIAPSA-L calcium;(2r)-2,4-dihydroxy-3,3-dimethyl-1-oxo-1-[[3-oxo-3-(2-sulfonatosulfanylethylamino)propyl]amino]butane Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSS([O-])(=O)=O.OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSS([O-])(=O)=O CILGDYPFLJJNKT-NAWJVIAPSA-L 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 claims description 4
- GOVINWHEYOSPAK-GPOMZPHUSA-N hexadecyl (2s,4r)-1-hexadecanoyl-4-hydroxypyrrolidine-2-carboxylate Chemical compound CCCCCCCCCCCCCCCCOC(=O)[C@@H]1C[C@@H](O)CN1C(=O)CCCCCCCCCCCCCCC GOVINWHEYOSPAK-GPOMZPHUSA-N 0.000 claims description 4
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 4
- 229940071085 lauroyl glutamate Drugs 0.000 claims description 4
- 229940073663 methyl trimethicone Drugs 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 4
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 4
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- 239000008117 stearic acid Substances 0.000 claims description 4
- ARYTXMNEANMLMU-UHFFFAOYSA-N 24alpha-methylcholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(C)C(C)C)C1(C)CC2 ARYTXMNEANMLMU-UHFFFAOYSA-N 0.000 claims 1
- ARYTXMNEANMLMU-ATEDBJNTSA-N campestanol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]2(C)CC1 ARYTXMNEANMLMU-ATEDBJNTSA-N 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 238000009499 grossing Methods 0.000 abstract description 13
- 239000006179 pH buffering agent Substances 0.000 abstract description 8
- 230000002421 anti-septic effect Effects 0.000 abstract description 7
- 230000032798 delamination Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 84
- 239000003921 oil Substances 0.000 description 60
- 239000000047 product Substances 0.000 description 27
- 238000012360 testing method Methods 0.000 description 17
- 230000037303 wrinkles Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- 239000010410 layer Substances 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 230000037394 skin elasticity Effects 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 6
- 239000004519 grease Substances 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 230000008591 skin barrier function Effects 0.000 description 4
- 150000001647 brassinosteroids Chemical class 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- AEQDJSLRWYMAQI-UHFFFAOYSA-N Tetrahydropalmatine Natural products C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000001153 anti-wrinkle effect Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910001431 copper ion Inorganic materials 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 235000002378 plant sterols Nutrition 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000036572 transepidermal water loss Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010034018 Parosmia Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- PXGZQGDTEZPERC-UHFFFAOYSA-L cyclohexane-1,4-dicarboxylate Chemical compound [O-]C(=O)C1CCC(C([O-])=O)CC1 PXGZQGDTEZPERC-UHFFFAOYSA-L 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- JFQWHJPQSSMFMH-UHFFFAOYSA-N methyl 4,5,6-trimethylpyrimidine-2-carboxylate Chemical compound COC(=O)C1=NC(=C(C(=N1)C)C)C JFQWHJPQSSMFMH-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/03—Liquid compositions with two or more distinct layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a water-oil biphase smoothing toner added with blue copper peptide and a preparation method thereof, wherein the smoothing toner comprises the following components in percentage by weight: 5 to 30 percent of humectant, 0.1 to 5 percent of preservative, 0.01 to 1.0 percent of tripeptide-1 copper, 1 to 30 percent of skin conditioning agent, 0.001 to 2 percent of penetration enhancer, 0.01 to 5 percent of pH buffering agent and 1 to 20 percent of oil phase; the preparation method comprises mixing water, humectant and antiseptic; then adding tripeptide-1 copper, partial skin conditioner and pH buffer in sequence, and adjusting the pH to 5.5-6.5; sequentially adding the rest skin conditioning agent and penetration enhancer to obtain water phase; taking an oil phase which is uniformly mixed, wherein the mass ratio of the water phase to the oil phase is 80-99: 1 to 20, and obtaining the finished product. The upper layer of the skin softening water is an oil phase, the lower layer of the skin softening water is a water phase, and the blue copper peptide is stabilized in the water phase, so that the skin softening water has the characteristics of good stability, quick oil-water delamination and clear interface.
Description
Technical Field
The invention relates to a skin softening aquatic product, in particular to a water-oil biphase skin softening product added with blue copper peptide and a preparation method thereof.
Background
Skin softening lotion is a kind of lotion used in the first step after face cleaning. Plays a role in basic skin care after the front opening. It can soften skin cuticle rapidly, supplement moisture for skin, and condition cuticle, make skin absorb other active components better, strengthen effects such as subsequent product repair, wrinkle resistance, etc.
Most of the prior smoothing toner is water phase of single-layer dosage form, more moisturizing and moisturizing are to increase the moisture content of skin cuticle immediately, no grease active ingredient with higher content is contained, the subsequent moisturizing and water locking are not durable enough, and the problem of skin dryness cannot be relieved fundamentally. Meanwhile, the pure water type skin softening water is difficult to add oil-soluble active ingredients into the product, so that the efficacy of the water aqua product is relatively single, and the effects such as repairing and anti-wrinkle are difficult to meet.
The double-layer smoothing toner is generally an upper-layer oil phase, a lower-layer water phase and the water phase are fully mixed for use. However, after the water-oil double layers are uniformly shaken, standing and layering are slow, even more than 24 hours are needed, an oil-water interface layer is turbid and opaque, more foam exists, the phenomenon of oil drop wall hanging is serious, and the appearance and the use feel are affected.
Blue copper peptide, also known as tripeptide-1 copper, derived from tripeptides GHK and Cu in human blood plasma 2+ A conjugated small molecule peptide. Research shows that the blue copper peptide can promote the synthesis of normal collagen and elastin of skin, promote the synthesis of small molecular proteoglycan and specific glycosaminoglycan, repair skin barrier, promote and help wound healing, improve skin elasticity and reduce skinWrinkles, etc.
Blue copper peptide is easy to oxidize, discolor and inactivate due to complexing copper ions, so that the ion of a finished product system is unstable, and the practical application is very limited. If blue copper peptide has poor compatibility with various antioxidants, plant extracts, thickeners, preservatives and other components, the blue copper peptide is easily complexed with other substances when added into cosmetics, and the effective components are destroyed, so that the pH value of a product system is unstable, and the phenomena of color change and smell change occur; in addition, although the blue copper peptide has strong hydrophilicity, the blue copper peptide is difficult to permeate into the deep layer of the acting skin, so that the real efficacy cannot be exerted.
Therefore, the water aqua product and the water-oil two-way product containing the blue copper peptide on the market generally have the problem of poor stability, the actual efficacy of the product is difficult to ensure, and the blue copper peptide skin softening water which simultaneously satisfies the water-oil two-phase with good stability, rapid water-oil phase layering and clear interface is difficult to prepare.
Disclosure of Invention
The invention aims to provide a water-oil biphase smoothing toner added with blue copper peptide and a preparation method thereof.
The technical scheme of the invention is as follows: the water-oil biphase smoothing toner added with the blue copper peptide comprises the following components in percentage by weight: 5 to 30 percent of humectant, 0.1 to 5 percent of preservative, 0.01 to 1.0 percent of tripeptide-1 copper, 1 to 30 percent of skin conditioning agent, 0.001 to 2 percent of penetration enhancer, 0.01 to 5 percent of pH buffering agent, 1 to 20 percent of oil phase and the balance of water.
The water-oil biphase skin softening water added with the blue copper peptide comprises the following components in percentage by weight: 8 to 20 percent of humectant, 0.5 to 3 percent of preservative, 0.05 to 0.5 percent of tripeptide-1 copper, 3 to 20 percent of skin conditioning agent, 0.1 to 1 percent of penetration enhancer, 0.05 to 3 percent of pH buffering agent, 5 to 15 percent of oil phase and the balance of water.
In the water-oil biphase skin softening water added with the blue copper peptide, the humectant comprises the following components in percentage by weight: 1 to 10 percent of 1,3 butanediol, 0.1 to 2 percent of 1,3 propanediol, 0.5 to 5 percent of glycerin, 0.001 to 1 percent of sodium hyaluronate and 0.01 to 2 percent of panthenol.
In the water-oil biphase skin softening water added with the blue copper peptide, the preservative comprises the following components in percentage by weight: 2.0 to 4.0 percent of 1, 2-pentanediol, 0.30 to 1.2 percent of 1, 2-hexanediol and 0.02 to 0.15 percent of ethylhexyl glycerol.
In the water-oil biphase skin softening water added with the blue copper peptide, the skin conditioner comprises the following components in percentage by weight: 0.05 to 5 percent of malto-oligosaccharin, 0.01 to 2 percent of tetrahydropalmatine carboxylic acid, 20.001 to 2 percent of biological gum, 0.05 to 3 percent of tetrandra root extract, 0.001 to 2 percent of calcium pantetheine sulfonate, 0.01 to 2 percent of glyceroglycoside, 50.0001 to 1 percent of palmitoyl tripeptide, 20.0001 to 1 percent of hexapeptide and 80.0001 to 1 percent of acetyl hexapeptide.
In the water-oil biphase smoothing toner added with the blue copper peptide, the pH buffering agent comprises the following components in percentage by weight: citric acid 0.001-1% and sodium citrate 0.001-1%.
In the water-oil biphase skin softening water added with the blue copper peptide, the penetration enhancer comprises the following components in percentage by weight: 0.001-1% of inositol and 0.001-1% of bis-diethoxydiglycol cyclohexane 1, 4-dicarboxylic acid ester.
In the water-oil biphase skin softening water added with the blue copper peptide, the oil phase comprises the following components in percentage by weight: isononyl isononanoate 0.5-3.0%, methyl trimethicone 0.2-2.0%, hydrogenated poly (C6-14 olefin) 0.5-5%, squalane 0.1-2%, hexyldecanol 0.01-1%, bisabolol 0.01-1%, N-palmitoyl hydroxyproline cetyl ester 0.01-1%, stearic acid 0.01-1%, brassinosteroids 0.001-1% and phytosterol/octyldodecanol lauroyl glutamate 0.01-1%.
A preparation method of water-oil biphase smoothing toner added with blue copper peptide comprises the following steps:
a. uniformly mixing water, 1,3 butanediol, 1,3 propylene glycol, glycerol and sodium hyaluronate, heating to 70-80 ℃, stirring and cooling to 50-60 ℃, and adding preservative and panthenol while stirring until cooling to 40-45 ℃ to obtain a product A;
b. sequentially adding maltooligosaccharide glucoside, tetrahydropyrimidine carboxylic acid, biological gum-2, tetrandra root extract, tripeptide-1 copper and pH buffer into the product A, regulating the pH to 5.5-6.5, uniformly stirring, and cooling to 30-35 ℃ to obtain a product B;
c. sequentially adding pantetheine calcium sulfonate, glyceroglycosides, palmitoyl tripeptide-5, hexapeptide-2, acetyl hexapeptide-8 and penetration enhancer into the product B, stirring uniformly, standing, cooling to room temperature to obtain a water phase, wherein the pH value of the water phase is 5.5-6.5;
d. taking an oil phase which is uniformly mixed, wherein the mass ratio of the water phase to the oil phase is 80-99: 1 to 20, and obtaining the finished product.
In the preparation method, in the step a, the cooling speed is 0.5-0.8 ℃/min, and the stirring speed is 150-250 r/min.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a water-oil biphase skin softening water added with blue copper peptide, which adopts a water-oil biphase form, wherein a water phase and an oil phase are mixed according to a specific proportion, the water phase is immediately supplemented with water, the oil phase is permanently locked, and the water phase and the oil phase are preferably composed of components, wherein the oil phase ratio can reach 20%, the water-oil phase layering speed is high, and the limit is clear.
The specific oil phase component selected by the invention adopts synthetic esters, low viscosity silicone oil and direct-linked alkane as main components, and the preferable proportion is 0.5-3.0% isononyl isononanoate, 0.2-2.0% methyl trimethyl silicone and 0.5-5% hydrogenated poly (C6-14 olefin). The composition and the proportion of the grease with three different structures provide balanced oily feel and excellent stability. The specific grease structure and proportion have small interfacial tension, are easy to spread out on the water surface, have large difference between the water and oil coefficients of the water phase, are quick to layer, have less foam and have clear oil-water interface.
According to the invention, the long carbon chain alkyl glycol composition is adopted as an antiseptic system, and is added in a specific proportion, and three alkyl glycols with different carbon chain lengths are preferably combined, so that the dosage of the whole antiseptic can be further reduced, an excellent antiseptic effect is achieved, the irritation of the conventional antiseptic to the skin is reduced to the greatest extent, and the antiseptic is suitable for skin sensitive people. The optimized preservative system has good compatibility with a pH buffering agent in the skin softening water, does not influence the pH of the system, can ensure the content of the blue copper peptide to the greatest extent, prevents copper ions from degrading, and effectively improves the bioactivity of the blue copper peptide. Through high temperature and light acceleration experiment investigation, the stability of the appearance, smell and blue copper peptide content of the skin softening water is good. Meanwhile, the optimal antiseptic system has large difference of water-oil distribution coefficients with oil phase components, is applied to the double-phase smoothing toner, so that the water-oil double-phase interface of the smoothing toner is clear, and the oil-water layer can be rapidly layered after shaking, and has good long-term storage stability.
In addition, the skin-friendly lipid component squalane and plant sterol grease are added into the oil phase, so that the skin adhesion of the blue copper peptide skin softening water can be improved, the brick wall structure of a skin barrier is supplemented, the skin-friendly lipid component squalane and plant sterol grease can be used for repairing a sebum membrane and a cuticle barrier under the combined action of the skin conditioner, such as tetramethyl pyrimidine carboxylic acid, pantetheine calcium sulfonate and the like, skin water and oil double-supplementing, and a myo-base water supplementing channel is opened, the penetration of the myo-ethanol and bis-diethoxydiglycol cyclohexane 1, 4-dicarboxylic ester penetration enhancer in the water phase to the deep skin is facilitated, meanwhile, the grease sealing effect can be further improved, the action time of the blue copper peptide in the water phase is prolonged, the blue copper peptide penetration promoting performance is improved, and the water-oil double-phase system can cooperate with the biological efficacy of the blue copper peptide; the blue copper peptide can play better roles of repairing, anti-wrinkle, tightening, relieving and the like in a skin softening water system.
The invention also provides a preparation method of the skin softening water, which has the advantages of simple operation and easy production, and is beneficial to the stability and efficacy exertion of the blue copper peptide; and the uniformity of the effective components is ensured by controlling the temperature and the stirring time.
Drawings
FIG. 1 is a graph of test results for skin redness;
fig. 2 is a graph of the test results of skin wrinkles.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to be limiting.
The water-oil biphase smoothing toner added with the blue copper peptide comprises the following components in percentage by weight: 5 to 30 percent of humectant, 0.1 to 5 percent of preservative, 0.01 to 1.0 percent of tripeptide-1 copper, 1 to 30 percent of skin conditioning agent, 0.001 to 2 percent of penetration enhancer, 0.01 to 5 percent of pH buffering agent, 1 to 20 percent of oil phase and the balance of water.
The humectant comprises the following components in percentage by weight: 1 to 10 percent of 1,3 butanediol, 0.1 to 2 percent of 1,3 propanediol, 0.5 to 5 percent of glycerin, 0.001 to 1 percent of sodium hyaluronate and 0.01 to 2 percent of panthenol.
The preservative comprises the following components in percentage by weight: 2.0 to 4.0 percent of 1, 2-pentanediol, 0.30 to 1.2 percent of 1, 2-hexanediol and 0.02 to 0.15 percent of ethylhexyl glycerol.
The skin conditioning agent comprises the following components in percentage by weight: 0.05 to 5 percent of malto-oligosaccharin, 0.01 to 2 percent of tetrahydropalmatine carboxylic acid, 20.001 to 2 percent of biological gum, 0.05 to 3 percent of tetrandra root extract, 0.001 to 2 percent of calcium pantetheine sulfonate, 0.01 to 2 percent of glyceroglycoside, 50.0001 to 1 percent of palmitoyl tripeptide, 20.0001 to 1 percent of hexapeptide and 80.0001 to 1 percent of acetyl hexapeptide.
The pH buffering agent comprises the following components in percentage by weight: citric acid 0.001-1% and sodium citrate 0.001-1%.
The penetration enhancer comprises the following components in percentage by weight: 0.001-1% of inositol and 0.001-1% of bis-diethoxydiglycol cyclohexane 1, 4-dicarboxylic acid ester.
The oil phase comprises the following components in percentage by weight: isononyl isononanoate 0.5-3.0%, methyl trimethicone 0.2-2.0%, hydrogenated poly (C6-14 olefin) 0.5-5%, squalane 0.1-2%, hexyldecanol 0.01-1%, bisabolol 0.01-1%, N-palmitoyl hydroxyproline cetyl ester 0.01-1%, stearic acid 0.01-1%, brassinosteroids 0.001-1% and phytosterol/octyldodecanol lauroyl glutamate 0.01-1%.
The preparation method of the skin softening lotion comprises the following steps:
a. uniformly mixing water, 1,3 butanediol, 1,3 propylene glycol, glycerol and sodium hyaluronate, heating to 70-80 ℃, stirring and cooling to 50-60 ℃, and adding preservative and panthenol while stirring until cooling to 40-45 ℃ to obtain a product A; the cooling speed is 0.5-0.8 ℃/min, and the stirring speed is 150-250 r/min.
b. Sequentially adding maltooligosaccharide glucoside, tetrahydropyrimidine carboxylic acid, biological gum-2, tetrandra root extract, tripeptide-1 copper and pH buffer into the product A, regulating the pH to 5.5-6.5, uniformly stirring, and cooling to 30-35 ℃ to obtain a product B;
c. sequentially adding pantetheine calcium sulfonate, glyceroglycosides, palmitoyl tripeptide-5, hexapeptide-2, acetyl hexapeptide-8 and penetration enhancer into the product B, stirring uniformly, standing, cooling to room temperature to obtain a water phase, wherein the pH value of the water phase is 5.5-6.5;
d. taking an oil phase which is uniformly mixed, wherein the mass ratio of the water phase to the oil phase is 80-99: 1 to 20, and obtaining the finished product.
Example 1:
the water-oil biphase smoothing toner added with the blue copper peptide comprises the following components in percentage by weight: humectant, preservative, tripeptide-1 copper 0.2%, skin conditioner, penetration enhancer, pH buffer, oil phase, and water.
The humectant comprises the following components in percentage by weight: 5% of 1, 3-butanediol, 0.5% of 1, 3-propanediol, 1% of glycerol, 0.05% of sodium hyaluronate and 1% of panthenol.
The preservative comprises the following components in percentage by weight: 3% of 1, 2-pentanediol, 1% of 1, 2-hexanediol and 1% of ethylhexyl glycerol.
The skin conditioning agent comprises the following components in percentage by weight: 2% of maltooligosaccharide glucoside, 0.5% of tetrahydropyrimidine carboxylic acid, 0.8% of biological gum-2, 2% of tetrandra extract, 1.2% of calcium pantetheine sulfonate, 1.5% of glyceroglycoside, 50.05% of palmitoyl tripeptide, 20.02% of hexapeptide and 0.07% of acetyl hexapeptide-8.
The pH buffering agent comprises the following components in percentage by weight: citric acid 0.01% and sodium citrate 0.07%.
The penetration enhancer comprises the following components in percentage by weight: 0.1% inositol and 0.15% bis-diethoxydiglycol cyclohexane 1, 4-dicarboxylate.
The oil phase comprises the following components in percentage by weight: isononyl isononanoate 3%, methyl trimethicone 1%, hydrogenated poly (C6-14 olefins) 1%, squalane 1%, hexyldecanol 0.01%, bisabolol 0.02%, N-palmitoyl hydroxyproline cetyl ester 0.02%, stearic acid 0.02%, brassinosteroids 0.02%, phytosterol/octyldodecanol lauroyl glutamate 0.01%
The preparation method of the skin softening lotion comprises the following steps:
the method comprises the following steps:
a. uniformly mixing water, 1,3 butanediol, 1,3 propylene glycol, glycerol and sodium hyaluronate, heating to 75 ℃, stirring and cooling to 55 ℃, wherein the cooling speed is 0.6 ℃/min, adding preservative and panthenol while stirring, and the stirring speed is 200r/min until the temperature is reduced to 43 ℃, thus obtaining a product A;
b. sequentially adding maltooligosaccharide glucoside, tetrahydropyrimidine carboxylic acid, biological gum-2, radix stephaniae tetrandrae extract, tripeptide-1 copper and pH buffer into the product A, adjusting the pH to 6, uniformly stirring, and cooling to 33 ℃ to obtain a product B;
c. sequentially adding pantetheine calcium sulfonate, glyceroglycosides, palmitoyl tripeptide-5, hexapeptide-2, acetyl hexapeptide-8, bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylic acid ester and inositol into the product B, uniformly stirring, standing, and cooling to room temperature to obtain a water phase;
d. taking an oil phase which is uniformly mixed, wherein the mass ratio of the water phase to the oil phase is 95:5, mixing to obtain a finished product.
According to the formulations in table 1, the skin softening water of example 1 and comparative examples 1 to 5 was prepared as a test sample according to the method of example 1, and performance test was performed.
Table 1 raw materials table for different test samples
1. Stability test:
the stability was measured by placing example 1 and comparative examples 1 to 5 at 45℃and 25℃and storing under the same light conditions and observing the initial state, the color at 2 weeks and the pH at 4 weeks of each test sample, and the test results are shown in Table 2.
TABLE 2 stability test results for different test samples
As is clear from the results of the above table, the color and pH of example 1 were stable under different conditions, whereas the effect of example 1 was not achieved in comparative examples 1 to 5.
2. Water-oil separation layer comparison
Samples prepared in example 1 and comparative examples 1 to 5 were placed in a 100mL measuring cylinder with a stopper and shaken up and down at the same speed for 30 times, and left to stand for observing the delamination speed of the water-oil phase, recording the time of complete delamination of the water-oil phase, recording the interface definition after 5 minutes, and whether there was a phenomenon of oil droplet wall built-up or not, to evaluate the water-oil phase, and the results are shown in table 3.
TABLE 3 comparison of the Water-oil separation of different test samples
It can be seen that the water-oil dual-phase smoothing toner prepared in example 1 has high water-oil layer layering speed after shaking, clear oil-water interface and no wall hanging phenomenon. While comparative examples 1 to 5 did not achieve the effect of example 1.
2. Human efficacy test:
a total of 60 female volunteers 35-45 years old were enrolled, and the skin status of 30 volunteers in each group was similar.
Volunteer screening criteria: the volunteer's face was required to be sensitive skin (passing lactic acid stinging test), and exhibited symptoms of skin lack of water, redness, local fever, etc., and the skin on one side of the face was dehydrated rate of trans-epidermal water loss TEWL in the cheek region>12g/h/m 2 The skin barrier is damaged and the eyes have macroscopic wrinkles.
The blue copper peptide skin softening lotion of example 1 and comparative example 5 was used twice daily for four weeks after each morning and evening face wash, respectively, with no other functional skin care product used. Skin test was performed on volunteers before use, 14 days, and 42 days, and the test values were averaged. The detection indexes comprise: skin moisture content, skin moisture loss, skin elasticity, skin thickness, skin wrinkles and skin color.
Skin moisture content skin stratum corneum moisture content was measured using a skin moisture meter corneometer cm 825;
skin moisture loss the skin transepidermal water loss rate was measured using a skin moisture loss meter TewameterTM 300;
skin elasticity the skin elasticity tester cutmeterdutamp a580 was used to measure skin elasticity;
skin thickness was measured by using an EUB-4 wig ultrasonic scanner produced by HITACHI, with a 7.5MHz linear probe, and focusing at an adjustable depth of 4-5 mm.
The detection results are shown in Table 4.
TABLE 4 human body test conditions of different test samples
(. Times. Shows significant differences (p < 0.05) in measured values compared to the product before use)
From the results, the skin softening water of comparative example 5 has certain effects of moisturizing and increasing skin elasticity, but the effect is relatively weak compared with the oil phase added in example 1, so that the oil phase of the skin softening water of the invention is helpful for the efficacy exertion of blue copper peptide, and has remarkable effects of moisturizing and moisturizing, delaying aging and increasing skin elasticity.
The skin softening water containing the blue copper peptide has the advantages that compared with the oil phase added in the comparative example 5, the skin thickness increasing effect of the example 1 is stronger than that of the comparative example 5, the oil phase and the water phase have synergistic effect, and the skin softening water has remarkable effects of slowing down skin sensitivity and repairing skin damage barriers and reducing skin redness.
Skin color and skin wrinkles were tested on the volunteer population using example 1.
The skin color adopts VISIA-CR to collect facial images and analyze skin color;
skin wrinkles facial image acquisition and skin wrinkles analysis were performed using Primos-CR.
The results of the test of red Pi Fufan (VISIA-CR) are shown in FIG. 1.
The greater the skin color a value, the redder the skin color (indicating a significant difference in measured values, p <0.05, compared to before sample use).
As can be seen from fig. 1, compared to before the sample was used:
the skin color a values of the test areas were significantly reduced by 2.86% after 14 days using the sample of example 1;
after 42 days using the sample of this example 1, the skin color a value of the test area was significantly reduced by 8.85%;
the results of the skin wrinkles (Primos-CR) -canthus wrinkles are shown in fig. 2.
The smaller the Ra value of the wrinkles, the more improved the skin wrinkles (x means a significant difference in measured values compared to before sample use, p < 0.05).
As can be seen from fig. 2, compared to before the sample was used:
after 14 days using the sample of this example 1, the Ra value of skin wrinkles in the corner of the eye was significantly reduced by 9.38%;
after 42 days using the sample of this example 1, the Ra value of skin wrinkles in the corner of the eye was significantly reduced by 11.17%;
in conclusion, the skin softening water containing the blue copper peptide has remarkable effects on skin redness and skin wrinkles, and the effects of repairing skin barriers and resisting wrinkles are shown.
Claims (3)
1. The water-oil biphase skin softening water added with the blue copper peptide is characterized by comprising a humectant, a preservative, tripeptide-1 copper, a skin conditioning agent, a penetration enhancer, a pH buffer agent, an oil phase and the balance of water, wherein the weight percentage of the water in the skin softening water is as follows,
the humectant comprises 1-10% of 1, 3-butanediol, 0.1-2% of 1, 3-propanediol, 0.5-5% of glycerol, 0.001-1% of sodium hyaluronate and 0.01-2% of panthenol;
the preservative consists of 2.0-4.0% of 1, 2-pentanediol, 0.30-1.2% of 1, 2-hexanediol and 1% of ethylhexyl glycerol;
the content of the tripeptide-1 copper is 0.01-1.0%;
the skin conditioner comprises 0.05-5% of maltooligosaccharide glucoside, 0.01-2% of tetrahydropyrimidine carboxylic acid, 0.001-2% of biogel-2, 0.05-3% of tetrandra root extract, 0.001-2% of calcium pantetheine sulfonate, 0.01-2% of glyceroglycoside, 5.0001-1% of palmitoyl tripeptide-5, 0.0001-1% of hexapeptide-2 and 0.0001-1% of acetyl hexapeptide-8;
the penetration enhancer comprises 0.001-1% of inositol and 0.001-1% of bis-diethoxydiglycol cyclohexane 1, 4-dicarboxylic acid ester;
the pH buffer consists of 0.001-1% of citric acid and 0.001-1% of sodium citrate; and
the oil phase comprises 0.5-3.0% isononyl isononanoate, 0.2-2.0% methyl trimethicone, 0.5-5% hydrogenated poly (C6-14 olefin), 0.1-2% squalane, 0.01-1% hexyldecanol, 0.01-1% bisabolol, 0.01-1% N-palmitoyl hydroxyproline cetyl ester, 0.01-1% stearic acid, 0.001-1% campestanol, and 0.01-1% phytosterol/octyldodecanol lauroyl glutamate.
2. The method for preparing the skin softening lotion according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:
a. uniformly mixing water, 1, 3-butanediol, 1, 3-propanediol, glycerol and sodium hyaluronate, heating to 70-80 ℃, stirring and cooling to 50-60 ℃, and adding preservative and panthenol while stirring until cooling to 40-45 ℃ to obtain a product A;
b. sequentially adding maltooligosaccharide glucoside, tetrahydropyrimidine carboxylic acid, biological gum-2, tetrandra root extract, tripeptide-1 copper and pH buffer into the product A, adjusting the pH to 5.5-6.5, uniformly stirring, and cooling to 30-35 ℃ to obtain a product B;
c. sequentially adding pantetheine calcium sulfonate, glyceroglycosides, palmitoyl tripeptide-5, hexapeptide-2, acetyl hexapeptide-8 and penetration enhancer into the product B, stirring uniformly, standing and cooling to room temperature to obtain a water phase;
d. taking an oil phase which is uniformly mixed, wherein the mass ratio of the water phase to the oil phase is 80-99: and (3) mixing 1-20 to obtain a finished product.
3. The preparation method according to claim 2, characterized in that: in the step a, the cooling speed is 0.5-0.8 ℃/min, and the stirring speed is 150-250 r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210770431.0A CN115006274B (en) | 2022-06-30 | 2022-06-30 | Water-oil biphase skin softening water added with blue copper peptide and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210770431.0A CN115006274B (en) | 2022-06-30 | 2022-06-30 | Water-oil biphase skin softening water added with blue copper peptide and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115006274A CN115006274A (en) | 2022-09-06 |
| CN115006274B true CN115006274B (en) | 2024-03-22 |
Family
ID=83079911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210770431.0A Active CN115006274B (en) | 2022-06-30 | 2022-06-30 | Water-oil biphase skin softening water added with blue copper peptide and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115006274B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117138021B (en) * | 2023-11-01 | 2024-01-09 | 南京斯拜科生物科技股份有限公司 | Compound based on blue copper peptide and tetrahydropyrimidine, preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110840786A (en) * | 2019-09-03 | 2020-02-28 | 江苏国实电子商务有限公司 | Blue copper peptide essence and preparation method thereof |
| CN113616542A (en) * | 2021-08-30 | 2021-11-09 | 浙江宜格企业管理集团有限公司 | Blue copper peptide repairing mask and preparation method thereof |
| CN114159369A (en) * | 2021-12-10 | 2022-03-11 | 江苏普罗诺生物科技有限公司 | Anti-wrinkle repair essence mask containing bluecopper peptides |
| CN114668684A (en) * | 2022-04-26 | 2022-06-28 | 凡可化妆品研究开发(广州)有限公司 | Composition containing bluecopper peptide and essence thereof |
-
2022
- 2022-06-30 CN CN202210770431.0A patent/CN115006274B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110840786A (en) * | 2019-09-03 | 2020-02-28 | 江苏国实电子商务有限公司 | Blue copper peptide essence and preparation method thereof |
| CN113616542A (en) * | 2021-08-30 | 2021-11-09 | 浙江宜格企业管理集团有限公司 | Blue copper peptide repairing mask and preparation method thereof |
| CN114159369A (en) * | 2021-12-10 | 2022-03-11 | 江苏普罗诺生物科技有限公司 | Anti-wrinkle repair essence mask containing bluecopper peptides |
| CN114668684A (en) * | 2022-04-26 | 2022-06-28 | 凡可化妆品研究开发(广州)有限公司 | Composition containing bluecopper peptide and essence thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115006274A (en) | 2022-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2370052B1 (en) | Novel sebum secretion inhibitory agent | |
| JP3670279B2 (en) | Anti-acne composition containing polya cocos wolf fungus extract | |
| CN110664644B (en) | Skin care composition containing folic acid, essence and preparation method thereof | |
| CN110974767A (en) | Composition for skin barrier regeneration repair and application thereof | |
| EP1633441B1 (en) | Cosmetic product containing mineral water for remineralising and rejuvenating the skin | |
| CN113616542A (en) | Blue copper peptide repairing mask and preparation method thereof | |
| CN115006274B (en) | Water-oil biphase skin softening water added with blue copper peptide and preparation method thereof | |
| CN103860453B (en) | A kind of face of living is compacted emollient cream and preparation method thereof | |
| CN113384507A (en) | Anti-aging composition and preparation method and application thereof | |
| EP1262169B1 (en) | Skin anti-ageing composition | |
| CN114931543A (en) | Repair anti-aging essence with high content of blue copper peptide and preparation method thereof | |
| CN112516066A (en) | Oil control composition and application thereof in cosmetics | |
| CN115813783A (en) | Water-oil double-agent instant emulsification type high-moisture-retention skin-brightening face mask and preparation method thereof | |
| CN113662882B (en) | Whitening, spot-fading and tightening essence and preparation method thereof | |
| CN108434067A (en) | Have effects that compact immediately skin skin care compositions and its application | |
| CN110141526B (en) | Moisturizing and anti-wrinkle emulsion and preparation method thereof | |
| CN113749972A (en) | Composition with anti-wrinkle effect and application of composition in cosmetics | |
| JP3877914B2 (en) | Skin cosmetics | |
| CN113384483A (en) | Composition for improving skin elasticity and delaying aging and preparation method thereof | |
| CN114668682B (en) | Moisturizing and skin-brightening composition and application thereof | |
| JP2000264833A (en) | Skin cosmetic | |
| JP3939857B2 (en) | Skin cosmetics | |
| JP4216866B2 (en) | Skin cosmetics | |
| CN114533642A (en) | Composition for tightening and brightening skin and preparation method thereof | |
| CN117898956A (en) | Lip-rounding cream composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20221114 Address after: 311116 Room 513-516, Building 5, No. 2, Kejiyuan Road, Baiyang Street, Qiantang District, Hangzhou City, Zhejiang Province Applicant after: Hangzhou Time Muscle Biotechnology Co.,Ltd. Address before: 310018 unit 08, 6 / F, building 5, No.2, kejiyuan Road, Baiyang street, Hangzhou Economic and Technological Development Zone, Zhejiang Province Applicant before: Zhejiang Yige Enterprise Management Group Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| CB02 | Change of applicant information |
Address after: Room 1-1017, Building 1, No. 1, Science Park Road, Baiyang Street, Qiantang District, Hangzhou City, Zhejiang Province, 310000 Applicant after: Hangzhou Time Muscle Biotechnology Co.,Ltd. Address before: 311116 Room 513-516, Building 5, No. 2, Kejiyuan Road, Baiyang Street, Qiantang District, Hangzhou City, Zhejiang Province Applicant before: Hangzhou Time Muscle Biotechnology Co.,Ltd. |
|
| CB02 | Change of applicant information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |