CN113616542A - Blue copper peptide repairing mask and preparation method thereof - Google Patents
Blue copper peptide repairing mask and preparation method thereof Download PDFInfo
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- CN113616542A CN113616542A CN202111003370.7A CN202111003370A CN113616542A CN 113616542 A CN113616542 A CN 113616542A CN 202111003370 A CN202111003370 A CN 202111003370A CN 113616542 A CN113616542 A CN 113616542A
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- blue
- essence
- skin
- peptide
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- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 title claims abstract description 45
- 241000530268 Lycaena heteronea Species 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000002562 thickening agent Substances 0.000 claims abstract description 40
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 24
- 239000003906 humectant Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241001530056 Athelia rolfsii Species 0.000 claims abstract description 18
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 12
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 12
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims abstract description 12
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 12
- 239000011734 sodium Substances 0.000 claims abstract description 12
- 239000000047 product Substances 0.000 claims description 113
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 40
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 36
- 239000003963 antioxidant agent Substances 0.000 claims description 28
- 230000003078 antioxidant effect Effects 0.000 claims description 28
- 230000001815 facial effect Effects 0.000 claims description 24
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 18
- 229960000458 allantoin Drugs 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 18
- 239000003995 emulsifying agent Substances 0.000 claims description 18
- 238000000855 fermentation Methods 0.000 claims description 18
- 230000004151 fermentation Effects 0.000 claims description 18
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 17
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 17
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 13
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 12
- 244000068988 Glycine max Species 0.000 claims description 12
- 235000010469 Glycine max Nutrition 0.000 claims description 12
- 241000186660 Lactobacillus Species 0.000 claims description 12
- 240000007817 Olea europaea Species 0.000 claims description 12
- 229940039696 lactobacillus Drugs 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 229940049964 oleate Drugs 0.000 claims description 12
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 12
- 229930182478 glucoside Natural products 0.000 claims description 11
- -1 glycerol glucoside Chemical class 0.000 claims description 11
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 6
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 6
- 239000004475 Arginine Substances 0.000 claims description 6
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 6
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims description 6
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
- KIUVQMGRTDPAFR-UHFFFAOYSA-N benzoic acid 2-hydroxy-2-phenylpropanamide Chemical compound C(C1=CC=CC=C1)(=O)O.OC(C(=O)N)(C)C1=CC=CC=C1 KIUVQMGRTDPAFR-UHFFFAOYSA-N 0.000 claims description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 238000013329 compounding Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 6
- 239000008267 milk Substances 0.000 claims description 6
- 210000004080 milk Anatomy 0.000 claims description 6
- 235000013336 milk Nutrition 0.000 claims description 6
- 229940101267 panthenol Drugs 0.000 claims description 6
- 235000020957 pantothenol Nutrition 0.000 claims description 6
- 239000011619 pantothenol Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- XKTQYKYYBXPELK-UHFFFAOYSA-N copper;cyanamide Chemical compound [Cu].NC#N XKTQYKYYBXPELK-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000004321 preservation Methods 0.000 claims 1
- 230000035699 permeability Effects 0.000 abstract description 13
- 210000003491 skin Anatomy 0.000 description 80
- 239000000686 essence Substances 0.000 description 61
- 239000000523 sample Substances 0.000 description 34
- 238000010521 absorption reaction Methods 0.000 description 15
- 238000001069 Raman spectroscopy Methods 0.000 description 12
- 239000010949 copper Substances 0.000 description 10
- 239000004744 fabric Substances 0.000 description 10
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 9
- 229910052802 copper Inorganic materials 0.000 description 9
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
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- 108010075016 Ceruloplasmin Proteins 0.000 description 3
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- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 238000001344 confocal Raman microscopy Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 238000001237 Raman spectrum Methods 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
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- 230000003595 spectral effect Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
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- 239000011573 trace mineral Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a blue copper peptide repairing mask and a preparation method thereof, wherein the essence comprises a humectant, a thickening agent, a penetration enhancer, a skin conditioner and water; the skin conditioner comprises, by mass, 0.1-0.5% of thickening agent, 0.10-0.30% of hydrolyzed sclerotium rolfsii gum, 0.5-3% of penetration enhancer and one or more of 0.02-0.20% of sodium polyglutamate and 0.001-0.05% of polyquaternium-51, and the skin conditioner comprises 0.1-0.5% of copper-blue peptide. The application has the characteristics of high stability and good permeability of the blue copper peptide.
Description
Technical Field
The invention relates to a mask and a preparation method, in particular to a blue copper peptide repairing mask and a preparation method.
Background
In recent years, the mask products are the products with the largest sales volume and the fastest growth speed in mask products. The facial mask comprises facial mask cloth and essence, wherein the facial mask cloth is used as a medium, adsorbs the essence, can be fixed at a specific position of a face to form a sealing layer, and promotes the absorption of the essence. The patch pack has the effects of instantly moisturizing, lightening and improving skin texture.
The structure sequence of the blue copper peptide (tripeptide-1 copper) is glycyl-L-histidyl-L-lysine-Cu (II), and the blue copper peptide is a compound of metal copper ions and tripeptide, wherein the tripeptide-1 is a small molecular protein consisting of three amino acids, and copper is a trace element required by maintaining body functions and is the earliest discovered polypeptide with a cosmetic effect. Research shows that the blue copper peptide has the effects of resisting aging and repairing. It can restore skin repair ability and reduce skin damage; stimulating glucose polyamine formation, increasing skin thickness; stimulating collagen formation and reducing the production of fine lines; the auxiliary antioxidant enzyme SOD has stronger free radical resisting function, delays senility and has wide application prospect.
However, the blue copper peptide is difficult to be widely applied to a face mask product. The reason is that the facial mask on the market generally needs to be thickened by high-molecular polymers such as carbomer and sodium polyacrylate for ensuring the viscosity of the essence and avoiding the phenomenon of dropping liquid, and the viscosity of the aqueous solution is increased through the hydrophilic association of the high polymers. However, the macromolecular thickening agent is easy to generate compatibility problem with the blue copper peptide, so that the blue copper peptide and the macromolecular thickening agent are neutralized, and the content stability of the blue copper peptide is influenced. On the other hand, when the copper-coated peptides are used as a face mask component and attached to the surface of the skin, the problem of insufficient permeability also occurs, so that the utilization rate of the copper-coated peptides and the soothing and repairing effect of the face mask are reduced.
Therefore, the existing face-mounted film containing the blue-copper peptide component has the problems of low stability and poor permeability of the blue-copper peptide.
Disclosure of Invention
The invention aims to provide a blue copper peptide repairing mask and a preparation method thereof. It has the characteristics of high stability and good permeability of the blue copper peptide.
The technical scheme of the invention is as follows: the blueprint peptide repairing mask comprises a mask body and essence, wherein the essence comprises a humectant, a thickening agent, a penetration enhancer, a skin conditioner and water; the thickening agent comprises 0.1-0.5% of hydrolyzed sclerotium rolfsii and 0.10-0.30% of sodium hyaluronate by mass fraction, the penetration enhancer comprises one or more of 0.5-3.0% of glycerol glucoside, 0.03-0.2% of sodium polyglutamate and 0.001-0.05% of polyquaternium-51, and the skin conditioner comprises 0.1-0.5% of copper-blue peptide.
In the above-mentioned blue copper peptide repairing mask, the thickener is composed of 0.22% of hydrolyzed sclerotium rolfsii gum and 0.15% of sodium hyaluronate by mass fraction, wherein the molecular weight of the hydrolyzed sclerotium rolfsii gum is 120 ten thousand Da, and the molecular weight of the sodium hyaluronate is 120 ten thousand Da.
In the above pack, the humectant consists of 2-8% by mass of butanediol, 1-4% by mass of glycerol, 1-2% by mass of glyceryl polyether-26 and 0.4-0.5% by mass of 1, 2-hexanediol.
In the above pack for repairing and protecting the bluecopper peptide, the penetration enhancer comprises, by mass, 0.5-3.0% of glycerol glucoside and a first compounding agent, wherein the first compounding agent is 0.03-0.2% of sodium polyglutamate and/or 0.01-0.05% of polyquaternium-51.
In the mask, the skin conditioner comprises, by mass, 0.1% of allantoin, 0.05-0.1% of chlorella extract, 0.25-0.75% of lactobacillus/soybean milk fermentation product filtrate, 0.25-0.75% of lactobacillus/rye fine powder fermentation product, 0.25-0.75% of bacillus/soybean fermentation product extract, 0.01-0.03% of arginine, 0.35-0.5% of panthenol, 0.2-1% of hydroxyphenylpropionamide benzoic acid and 0.1-0.5% of bluecopper peptide.
In the above pack, the essence further comprises an antioxidant and an emulsifier, wherein the antioxidant is 0.4-0.5% of p-hydroxyacetophenone by mass, and the emulsifier is composed of 0.06-0.18% of cetearyl olive oleate and 0.04-0.12% of sorbitan olive oleate.
In the preparation method of the blue copper peptide repairing mask, the preparation method of the essence comprises the following steps:
uniformly mixing a humectant, a thickening agent, water and allantoin in a skin conditioner in proportion, adding the mixture into an emulsifying pot, heating to 70-75 ℃, adding an antioxidant, stirring until the antioxidant is completely dissolved, and keeping the temperature for 30 minutes to obtain a product A;
secondly, mixing the penetration enhancer and the emulsifier in proportion, adding the product A, and stirring until the mixture is completely dissolved to obtain a product b 1; homogenizing the product B1 at 2000 rpm for 3 min to obtain product B;
thirdly, cooling the product B to 45 ℃ at the speed of 0.5 ℃/minute, and then adding the residual skin conditioner except the allantoin and the copper-blue peptide to obtain a product C;
fourthly, cooling the product C to 40 ℃ at the speed of 0.5 ℃/minute, then adding the antioxidant and the copper-coated peptides in the skin conditioner, and stirring for 15 minutes at the constant temperature to obtain a product d 1; cooling D1 product to 35 deg.C at a rate of 0.5 deg.C/min, and discharging to obtain D product;
and fifthly, filtering the product D by using a 100-mesh filter screen to obtain a finished product of the essence.
In the preparation method, the pH value of the finished product of the essence in the fifth step is 5.5-6.5, and the viscosity of the finished product of the essence is 800-1500 cP.
Compared with the prior art, the invention has the following characteristics
(1) According to the invention, the essence is thickened by adopting the hydrolyzed sclerotium rolfsii and the sodium hyaluronate with specific molecular weights as the thickening agents, and compared with a macromolecular thickening agent, the thickening agent can effectively avoid neutralization with the blue copper peptide, so that the content stability of the blue copper peptide in the essence is improved; meanwhile, compared with a high-molecular thickener, the thickener also has better skin compatibility and soft filming feel, so that the skin sticking effect of the mask is improved; on the basis, the invention further defines the components and the proportion of the humectant, so that the humectant can have excellent viscoelasticity and water retention after being thickened by the thickener;
(2) the invention limits the components of the penetration enhancer, so that the glycerol glucoside in the penetration enhancer can be beneficial to intercellular aquaporin and improve the permeability of active hydrophilic components; the sodium polyglutamate or polyquaternium-51 can be selectively adsorbed with the copper peptide, so that the transdermal property of the copper peptide can be improved; meanwhile, compared with other skin care products, the method for attaching the essence to the face by using the facial mask can enable the face to bear higher osmotic pressure, so that an invisible osmotic pressure membrane is formed, the micro-pressure promotes the permeation, and the permeability of the blue copper peptide in the skin is further improved;
(3) on the basis, the viscosity value of the essence after being combined can reach 800-1500 cP through further limiting and content optimizing of each component, namely the optimal viscosity range required by the facial mask essence is reached; compared with the existing mask essence without the penetration enhancer and the thickening agent, the penetration of the essence to the skin surface in a short time and the content stability of the essence after long-term storage can be obviously improved;
therefore, the invention has the characteristics of high stability and good permeability of the blue copper peptide.
Detailed Description
The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.
Example 1. The blue copper peptide repairing mask comprises a mask and essence, wherein the mask is a fiber mask cloth, and the essence comprises a humectant, a thickening agent, a penetration enhancer, a skin conditioner and water; the thickening agent comprises 0.1-0.5% of hydrolyzed sclerotium rolfsii and 0.10-0.30% of sodium hyaluronate by mass fraction, the penetration enhancer comprises one or more of 0.5-3.0% of glycerol glucoside, 0.03-0.2% of sodium polyglutamate and 0.001-0.05% of polyquaternium-51, and the skin conditioner comprises 0.1-0.5% of copper-blue peptide.
The thickening agent consists of 0.22% of hydrolyzed sclerotium rolfsii gum and 0.15% of sodium hyaluronate in mass fraction, wherein the molecular weight of the hydrolyzed sclerotium rolfsii gum is 120 ten thousand Da, and the molecular weight of the sodium hyaluronate is 120 ten thousand Da.
The humectant consists of 2-8% of butanediol, 1-4% of glycerol, 1-2% of glyceryl polyether-26 and 0.4-0.5% of 1, 2-hexanediol by mass.
The penetration enhancer comprises 0.5-3.0% of glycerol glucoside and a first compounding agent by mass, wherein the first compounding agent is 0.03-0.2% of sodium polyglutamate and/or 0.01-0.05% of polyquaternium-51; the glycerol glucoside can fully infiltrate stratum corneum cells, is beneficial to opening aquaporins, improves the transdermal property of the blue copper peptide, and acts on the stratum corneum bottom layer; the sodium polyglutamate has super-strong water-locking and moisture-preserving capability, excellent skin affinity, reversible and changeable molecular configuration and the effects of embedding and releasing active ingredients, and a high molecular water network formed after water absorption can adsorb water-soluble active ingredients and permeate and slowly release the water-soluble active ingredients to the bottom layer of the skin stratum corneum; the polyquaternium-51 contains hydrophilic phosphate groups and hydrophobic alkyl chains, has a structure very similar to that of phospholipid of skin, can form a phospholipid bilayer structure membrane after acting on the skin by forming intercellular layers entering stratum corneum and granular layers of the skin, obviously increases the water content of the skin, and can increase the permeability of hydrophilic active substances.
The skin conditioner comprises, by mass, 0.1% of allantoin, 0.05-0.1% of chlorella extract, 0.25-0.75% of lactobacillus/soybean milk fermentation product filtrate, 0.25-0.75% of lactobacillus/rye fine powder fermentation product, 0.25-0.75% of bacillus/soybean fermentation product extract, 0.01-0.03% of arginine, 0.35-0.5% of panthenol, 0.2-1% of hydroxyphenylpropionamide benzoic acid and 0.1-0.5% of copper-cyanamide.
The essence also comprises an antioxidant and an emulsifier, wherein the antioxidant is 0.4-0.5% of p-hydroxyacetophenone by mass, and the emulsifier is composed of 0.06-0.18% of cetearyl olive oleate and 0.04-0.12% of sorbitan olive oleate.
In the preparation method of the blue copper peptide repairing mask, the preparation method of the essence comprises the following steps:
uniformly mixing a humectant, a thickening agent, water and allantoin in a skin conditioner in proportion, adding the mixture into an emulsifying pot, heating to 70-75 ℃, adding an antioxidant, stirring until the antioxidant is completely dissolved, and keeping the temperature for 30 minutes to obtain a product A;
secondly, mixing the penetration enhancer and the emulsifier in proportion, adding the product A, and stirring until the mixture is completely dissolved to obtain a product b 1; homogenizing the product B1 at 2000 rpm for 3 min to obtain product B;
thirdly, cooling the product B to 45 ℃ at the speed of 0.5 ℃/minute, and then adding the residual skin conditioner except the allantoin and the copper-blue peptide to obtain a product C;
fourthly, cooling the product C to 40 ℃ at the speed of 0.5 ℃/minute, then adding the antioxidant and the copper-coated peptides in the skin conditioner, and stirring for 15 minutes at the constant temperature to obtain a product d 1; cooling D1 product to 35 deg.C at a rate of 0.5 deg.C/min, and discharging to obtain D product;
and fifthly, filtering the product D by using a 100-mesh filter screen to obtain a finished product of the essence.
And fifthly, the pH value of the finished product of the essence is 5.5-6.5, and the viscosity of the finished product of the essence is 800-1500 cP.
The working principle of the invention is as follows: according to the invention, through the matching limitation of the components of the thickening agent and the humectant, the viscosity of the essence can be effectively improved, so that the essence can be firmly adsorbed on mask cloth, and the mask cloth has good skin-sticking performance when in use, reduces the percutaneous moisture loss of skin, and improves the moisture content of the skin. Meanwhile, the thickening agent disclosed by the invention is thickened by adopting colloid, so that the neutralization reaction with the blue copper peptide can be effectively reduced compared with a high-molecular thickening agent, and the stability of the blue copper peptide is ensured. By limiting the components of the penetration enhancer, the permeability of the whole essence and the compatibility with a skin biological membrane can be improved, so that the permeability of the blue copper peptide in the skin is improved. Under the cooperation, the invention can effectively avoid the problems of compatibility and stability of the blue copper peptide in the essence, and can quickly permeate the skin surface when in use, thereby exerting the efficacy of the blue copper peptide to the maximum extent.
Example 2. The blue copper peptide repairing mask comprises a mask and essence, wherein the mask is a fiber mask cloth, and the essence consists of a humectant, a thickening agent, a penetration enhancer, a skin conditioner, an antioxidant, an emulsifier and water; in terms of mass fraction, the amount of the active ingredient,
the humectant is 2% of butanediol, 1% of glycerol, 2% of glyceryl polyether-26 and 0.5% of 1, 2-hexanediol;
the thickening agent is 0.22% of hydrolyzed sclerotium rolfsii glue and 0.15% of sodium hyaluronate, and the molecular weight of the hydrolyzed sclerotium rolfsii glue and the sodium hyaluronate are both 120 ten thousand Da;
the penetration enhancer is 3.0% of glycerol glucoside and 0.03% of sodium polyglutamate;
the emulsifier is 0.18% cetearyl olive oleate and 0.12% sorbitan olive oleate;
the antioxidant is 0.5% of p-hydroxyacetophenone;
the skin conditioner is composed of 0.1% of allantoin, 0.1% of chlorella extract, 0.25% of lactobacillus/soybean milk fermentation product filtrate, 0.25% of lactobacillus/rye fine powder fermentation product, 0.25% of bacillus/soybean fermentation product extract, 0.01% of arginine, 0.5% of panthenol, 0.2% of hydroxyphenylpropionamide benzoic acid and 0.1% of ceruloplasmin;
the residual mass fraction is water.
In the preparation method of the blue copper peptide repairing mask, the preparation method of the essence comprises the following steps:
uniformly mixing a humectant, a thickening agent, water and allantoin in a skin conditioner in proportion, adding the mixture into an emulsifying pot, heating to 70-75 ℃, adding an antioxidant, stirring until the antioxidant is completely dissolved, and keeping the temperature for 30 minutes to obtain a product A;
secondly, mixing the penetration enhancer and the emulsifier in proportion, adding the product A, and stirring until the mixture is completely dissolved to obtain a product b 1; homogenizing the product B1 at 2000 rpm for 3 min to obtain product B;
thirdly, cooling the product B to 45 ℃ at the speed of 0.5 ℃/minute, and then adding the residual skin conditioner except the allantoin and the copper-blue peptide to obtain a product C;
fourthly, cooling the product C to 40 ℃ at the speed of 0.5 ℃/minute, then adding the antioxidant and the copper-coated peptides in the skin conditioner, and stirring for 15 minutes at the constant temperature to obtain a product d 1; cooling D1 product to 35 deg.C at a rate of 0.5 deg.C/min, and discharging to obtain D product;
and fifthly, filtering the product D by using a 100-mesh filter screen to obtain a finished product of the essence.
In the fifth step, the pH value of the finished product of the essence is 5.58, and the viscosity of the finished product of the essence is 900 cP.
Example 3. The blue copper peptide repairing mask comprises a mask and essence, wherein the mask is a fiber mask cloth, and the essence consists of a humectant, a thickening agent, a penetration enhancer, a skin conditioner, an antioxidant, an emulsifier and water; in terms of mass fraction, the amount of the active ingredient,
the humectant is 5% of butanediol, 2% of glycerol, 1% of glyceryl polyether-26 and 0.4% of 1, 2-hexanediol;
the thickening agent is 0.25% of hydrolyzed sclerotium rolfsii glue and 0.3% of sodium hyaluronate, and the molecular weight of the hydrolyzed sclerotium rolfsii glue and the sodium hyaluronate are both 120 ten thousand Da;
the penetration enhancer is 1% of glycerol glucoside, 0.12% of sodium polyglutamate and 0.01% of polyquaternium-51;
the emulsifier is 0.06% cetearyl olive oleate and 0.04% sorbitan olive oleate;
the antioxidant is 0.4% of p-hydroxyacetophenone;
the skin conditioner is composed of 0.1% of allantoin, 0.05% of chlorella extract, 0.5% of lactobacillus/soybean milk fermentation product filtrate, 0.5% of lactobacillus/rye fine powder fermentation product, 0.5% of bacillus/soybean fermentation product extract, 0.02% of arginine, 0.35% of panthenol, 1% of hydroxyphenylpropionamide benzoic acid and 0.25% of ceruloplasmin;
the residual mass fraction is water.
In the preparation method of the blue copper peptide repairing mask, the preparation method of the essence comprises the following steps:
uniformly mixing a humectant, allantoin in a skin conditioner and water in proportion, adding the mixture into an emulsifying pot, heating to 70-75 ℃, and keeping the temperature for 30 minutes to obtain a product A;
secondly, mixing the penetration enhancer and the emulsifier in proportion, adding the product A, and stirring until the mixture is completely dissolved to obtain a product b 1; homogenizing the product B1 at 2000 rpm for 3 min to obtain product B;
thirdly, cooling the product B to 45 ℃ at the speed of 0.5 ℃/minute, and then adding the residual skin conditioner except the allantoin and the copper-blue peptide to obtain a product C;
fourthly, cooling the product C to 40 ℃ at the speed of 0.5 ℃/minute, then adding the antioxidant and the copper-coated peptides in the skin conditioner, and stirring for 15 minutes at the constant temperature to obtain a product d 1; cooling D1 product to 35 deg.C at a rate of 0.5 deg.C/min, and discharging to obtain D product;
and fifthly, filtering the product D by using a 100-mesh filter screen to obtain a finished product of the essence.
In the fifth step, the pH value of the finished product of the essence is 6.12, and the viscosity of the finished product of the essence is 1250 cP.
Example 4. The blue copper peptide repairing mask comprises a mask and essence, wherein the mask is a fiber mask cloth, and the essence consists of a humectant, a thickening agent, a penetration enhancer, a skin conditioner, an antioxidant, an emulsifier and water; in terms of mass fraction, the amount of the active ingredient,
the humectant is 8% of butanediol, 4% of glycerol, 2% of glyceryl polyether-26 and 0.45% of 1, 2-hexanediol;
the thickening agent is 0.5% of hydrolyzed sclerotium rolfsii glue and 0.1% of sodium hyaluronate, and the molecular weight of the hydrolyzed sclerotium rolfsii glue and the sodium hyaluronate are both 120 ten thousand Da;
the penetration enhancer is 0.5% of glycerol glucoside, 0.2% of sodium polyglutamate and 0.05% of polyquaternium-51;
the emulsifier is 0.18% cetearyl olive oleate and 0.12% sorbitan olive oleate;
the antioxidant is 0.45% of p-hydroxyacetophenone;
the skin conditioner is composed of 0.1% of allantoin, 0.1% of chlorella extract, 0.75% of lactobacillus/soybean milk fermentation product filtrate, 0.75% of lactobacillus/rye fine powder fermentation product, 0.75% of bacillus/soybean fermentation product extract, 0.03% of arginine, 0.5% of panthenol, 1% of hydroxyphenylpropionamide benzoic acid and 0.5% of ceruloplasmin;
the residual mass fraction is water.
In the preparation method of the blue copper peptide repairing mask, the preparation method of the essence comprises the following steps:
uniformly mixing a humectant, a thickening agent, water and allantoin in a skin conditioner in proportion, adding the mixture into an emulsifying pot, heating to 70-75 ℃, adding an antioxidant, stirring until the antioxidant is completely dissolved, and keeping the temperature for 30 minutes to obtain a product A;
secondly, mixing the penetration enhancer and the emulsifier in proportion, adding the product A, and stirring until the mixture is completely dissolved to obtain a product b 1; homogenizing the product B1 at 2000 rpm for 3 min to obtain product B;
thirdly, cooling the product B to 45 ℃ at the speed of 0.5 ℃/minute, and then adding the residual skin conditioner except the allantoin and the copper-blue peptide to obtain a product C;
fourthly, cooling the product C to 40 ℃ at the speed of 0.5 ℃/minute, then adding the antioxidant and the copper-coated peptides in the skin conditioner, and stirring for 15 minutes at the constant temperature to obtain a product d 1; cooling D1 product to 35 deg.C at a rate of 0.5 deg.C/min, and discharging to obtain D product;
and fifthly, filtering the product D by using a 100-mesh filter screen to obtain a finished product of the essence.
In the fifth step, the pH value of the finished product of the essence is 6.45, and the viscosity of the finished product of the essence is 1450 cP.
Experimental example 1: the sclerotium rolfsii gum and the sodium hyaluronate in the essence are compounded according to the proportion in the table 1, prepared and molded, and the hydroxyethyl cellulose and the xanthan gum are compounded according to the proportion to replace the thickener component in the essence to serve as a comparison group; the viscosity values were then measured using a Brookfield DV2T viscometer at 16 spindle, 6 rpm. The results are shown in table 1:
TABLE 1 comparison of viscosity values of essences at different thickener addition levels
According to the detection result, the viscosity of the essence can be effectively improved to 800-1500 cP by limiting the components and the proportion of the thickening agent, the facial mask essence and the facial mask cloth in the viscosity range have good wettability, the facial mask cloth is soft, and the facial mask essence is thick and non-sticky, is smooth and non-greasy and does not drip into filaments when being used. However, the viscosity value cannot be achieved by using other thickener components such as hydroxyethyl cellulose and xanthan gum.
Experimental example 2: selecting Chinese healthy subjects with red face skin (red blood, acne marks, and the like), face dandruff (subject proportion is 40-60%), skin sensitivity (subject proportion is 40-60%), and age range of 18-60 years (subject age is 18-30 years 50%, subject age is 31-60 years 50%). The subject's skin needs encompass dry skin, oily skin, neutral skin, mixed-drier skin, and mixed-oiler skin. The daily skin care habit of the testee is not changed, the testee uses a piece of facial mask sample of the application after cleaning the face at night, the facial mask sample is attached to the face for 15min and then taken down, and the facial mask sample is gently massaged until the essence is completely absorbed. The composition is administered 1 time every 7 days for a total of 28 days.
Subjects before and 28 days after application of the samples, VISIA-CR images of the subjects' faces were taken, VC20 Plus was used to take images of the subjects and analyze cheek skin roughness SEr, skin smoothness SEsm, stratum corneum moisture content meter CM 825 was used to measure cheek stratum corneum moisture content, skin surface moisture loss meter Te meter TM 300 was used to measure cheek transdermal moisture loss, skin gloss probe Glossy meter GL200 was used to measure skin gloss, and vitreochromatism test probe Colorimeter CL400 was used to measure skin color red-green values, respectively. The detection effect is shown in table 2:
TABLE 2 test results of the subjects before and after the mask application on each skin care index
According to the detection results, after the test sample is used for 28 days, the moisture content of the horny layer of the cheek of the test subject is obviously increased by 32.71%, the moisture loss of the skin of the cheek is obviously reduced by 23.23%, the glossiness of the skin of the cheek is obviously increased by 16.98%, the color a value of the skin of the cheek is obviously reduced by 4.95%, and the roughness of the skin of the cheek SEr is obviously improved by 26.89%. The results show that the facial mask has the effects of remarkably improving the moisture content of the skin, remarkably repairing the skin barrier, remarkably brightening the skin, remarkably improving the skin redness and remarkably improving the skin smoothness after being used for 28 days.
Experimental example 3: in this example, the essence, the mask solution without the permeation enhancer and the mask solution with other conventional permeation enhancer components were used as comparison groups (the components of the mask solutions in sample 4 and sample 5 except the permeation enhancer were the same as those in samples 1 to 3), and the permeability of the blue-green peptide was measured by confocal micro-raman spectroscopy.
Selecting 5 healthy subjects, selecting the bent sides of the left and right forearms, testing the area of 3cm by 3cm, and smearing the facial mask liquid sample once with the smearing dosage of 2mg/cm2And waiting for 5min, after the sample is completely absorbed, testing the Raman spectra at the position of 0-30 mu m of the skin before use, 1h after use and 2h after use by using a confocal micro-Raman spectrometer, and collecting the Raman signals of the test area. And comparing with the skin Raman signal before use to determine the characteristic signal peak of the cosmetic to be detected.And comparing the characteristic signal peak intensity of the cosmetics with the spectral intensity of the skin, and calculating the transdermal absorption relative quantity (in percentage) of the cosmetics at different depths of the skin by using a mathematical model, wherein the transdermal absorption relative quantity indicates the transdermal property of the essence, and the higher the absorption quantity, the better the transdermal absorption property and the higher the permeability of the copper-blue peptide. The control ratios are shown in table 3:
TABLE 3 comparison of the permeability of the mask at different penetration enhancing agent conditions
The analysis result of the sample 1 shows that the Raman signal of the sample 1 is detected at the skin depth of 15 mu m 1h after the use, and the calculated percutaneous absorption relative quantity of the sample 1 is 10.65 percent respectively; the raman signal of sample 1 was still detectable at a skin depth of 30 μm 2h after use, and the calculated relative amount of percutaneous absorption of sample 1 was 5.35% respectively.
The analysis result of the sample 2 shows that the Raman signal of the sample 2 is detected at the skin depth of 15 mu m 1h after the use, and the calculated percutaneous absorption relative quantity of the sample 2 is 11.77 percent respectively; the raman signal of sample 2 was still detectable at a skin depth of 30 μm 2h after use, and the calculated relative amount of percutaneous absorption of sample 2 was 6.35% respectively.
The analysis result of the sample 3 shows that the Raman signal of the sample 3 is detected at the skin depth of 15 mu m 1h after the use, and the calculated percutaneous absorption relative quantity of the sample 3 is 15.48 percent respectively; the raman signal of sample 3 was still detectable at a skin depth of 30 μm 2h after use, and the calculated relative amount of percutaneous absorption of sample 3 was 8.35% respectively.
The analysis result of the sample 4 shows that the Raman signal of the sample 4 is detected at the skin depth of 15 mu m 1h after the use, and the calculated percutaneous absorption relative quantity of the sample 4 is respectively 2.35 percent; at 2h after use, no raman signal of sample 4 was detected at a skin depth of 30 μm.
The analysis result of the sample 5 shows that the Raman signal of the sample 1 is detected at the skin depth of 15 mu m 1h after the use, and the calculated percutaneous absorption relative quantity of the sample 5 is 5.65 percent respectively; the raman signal of the sample 5 was still detectable at a skin depth of 30 μm 2h after use, and the calculated relative amount of percutaneous absorption of the sample 5 was 1.35%, respectively.
According to experimental results, compared with facial mask liquid added with other penetration enhancers or without penetration enhancer, the penetration of the essence can be effectively improved by limiting the ingredients and the proportion of the penetration enhancers.
Experimental example 4: the essence and the essence prepared by adopting a high-molecular thickening agent (sodium polyacrylate) are used as comparative examples, 0.20 mass percent of blue copper peptide is added, the stability of the content of the blue copper peptide is investigated through accelerated experiments under different environments, and the content of the blue copper peptide is tested through a high performance liquid chromatography. The results are shown in table 4:
TABLE 4 comparison of stability of the bluecopper peptides under different serum conditions
According to the experimental result, compared with the facial mask liquid adopting the macromolecular thickening agent, the essence thickened by the colloid can make the content of the blue copper peptide under different environments more stable.
Claims (8)
1. The blue copperpeptide repairing facial mask comprises a facial mask and essence, and is characterized in that: the essence comprises a humectant, a thickener, a penetration enhancer, a skin conditioner and water; the thickening agent comprises 0.1-0.5% of hydrolyzed sclerotium rolfsii and 0.10-0.30% of sodium hyaluronate by mass fraction, the penetration enhancer comprises one or more of 0.5-3.0% of glycerol glucoside, 0.03-0.2% of sodium polyglutamate and 0.001-0.05% of polyquaternium-51, and the skin conditioner comprises 0.1-0.5% of copper-blue peptide.
2. The blue copopeptide facial mask according to claim 1, wherein: the thickening agent consists of 0.22% of hydrolyzed sclerotium rolfsii gum and 0.15% of sodium hyaluronate in mass fraction, wherein the molecular weight of the hydrolyzed sclerotium rolfsii gum is 120 ten thousand Da, and the molecular weight of the sodium hyaluronate is 120 ten thousand Da.
3. The blue copopeptide facial mask according to claim 1, wherein: the humectant consists of 2-8% of butanediol, 1-4% of glycerol, 1-2% of glyceryl polyether-26 and 0.4-0.5% of 1, 2-hexanediol by mass.
4. The blue copopeptide facial mask according to claim 1, wherein: the penetration enhancer comprises, by mass, 0.5-3.0% of glycerol glucoside and a first compounding agent, wherein the first compounding agent is 0.03-0.2% of sodium polyglutamate and/or 0.01-0.05% of polyquaternium-51.
5. The blue copopeptide facial mask according to claim 1, wherein: the skin conditioner comprises, by mass, 0.1% of allantoin, 0.05-0.1% of chlorella extract, 0.25-0.75% of lactobacillus/soybean milk fermentation product filtrate, 0.25-0.75% of lactobacillus/rye fine powder fermentation product, 0.25-0.75% of bacillus/soybean fermentation product extract, 0.01-0.03% of arginine, 0.35-0.5% of panthenol, 0.2-1% of hydroxyphenylpropionamide benzoic acid and 0.1-0.5% of copper-cyanamide.
6. The blue copopeptide facial mask according to claim 1, wherein: the essence also comprises an antioxidant and an emulsifier, wherein the antioxidant is 0.4-0.5% of p-hydroxyacetophenone by mass, and the emulsifier is composed of 0.06-0.18% of cetearyl olive oleate and 0.04-0.12% of sorbitan olive oleate.
7. The preparation method of the blue copper peptide repairing mask based on any one of claims 1 to 6, wherein the preparation method of the essence comprises the following steps:
uniformly mixing a humectant, a thickening agent, water and allantoin in a skin conditioner in proportion, adding the mixture into an emulsifying pot, heating to 70-75 ℃, adding an antioxidant, stirring until the antioxidant is completely dissolved, and keeping the temperature for 30 minutes to obtain a product A;
secondly, mixing the penetration enhancer and the emulsifier in proportion, adding the product A, and stirring until the mixture is completely dissolved to obtain a product b 1; homogenizing the product B1 at 2000 rpm for 3 min to obtain product B;
thirdly, cooling the product B to 45 ℃ at the speed of 0.5 ℃/minute, and then adding the residual skin conditioner except the allantoin and the copper-blue peptide to obtain a product C;
fourthly, cooling the product C to 40 ℃ at the speed of 0.5 ℃/minute, then adding the blue copper peptide in the skin conditioner, and stirring for 15 minutes under the condition of heat preservation to obtain a product d 1; cooling D1 product to 35 deg.C at a rate of 0.5 deg.C/min, and discharging to obtain D product;
and fifthly, filtering the product D by using a 100-mesh filter screen to obtain a finished product of the essence.
8. The method of claim 7, wherein: and fifthly, the pH value of the finished product of the essence is 5.5-6.5, and the viscosity of the finished product of the essence is 800-1500 cP.
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| CN114042007A (en) * | 2021-11-22 | 2022-02-15 | 广东丸美生物技术股份有限公司 | L-carnitine-based blue copper peptide ionic liquid and preparation method and application thereof |
| CN114159369A (en) * | 2021-12-10 | 2022-03-11 | 江苏普罗诺生物科技有限公司 | Anti-wrinkle repair essence mask containing bluecopper peptides |
| CN115068361A (en) * | 2022-03-15 | 2022-09-20 | 中山中研化妆品有限公司 | Blue copper peptide double agent and use method and application thereof |
| CN115068361B (en) * | 2022-03-15 | 2023-11-03 | 中山中研化妆品有限公司 | Blue copper peptide double-agent and use method and application thereof |
| CN114931543A (en) * | 2022-06-13 | 2022-08-23 | 浙江宜格企业管理集团有限公司 | Repair anti-aging essence with high content of blue copper peptide and preparation method thereof |
| CN114931543B (en) * | 2022-06-13 | 2024-03-08 | 杭州时光肌生物科技有限公司 | Repairing and anti-aging essence with high content of blue copper peptide and preparation method thereof |
| CN115006274A (en) * | 2022-06-30 | 2022-09-06 | 浙江宜格企业管理集团有限公司 | Water-oil two-phase smoothing toner added with copper vicryl peptide and preparation method |
| CN115006274B (en) * | 2022-06-30 | 2024-03-22 | 杭州时光肌生物科技有限公司 | Water-oil biphase skin softening water added with blue copper peptide and preparation method thereof |
| CN115252458A (en) * | 2022-09-01 | 2022-11-01 | 上海家化联合股份有限公司 | Stable moisturizing composition containing blue copper peptide |
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Effective date of registration: 20221111 Address after: 311116 Room 513-516, Building 5, No. 2, Kejiyuan Road, Baiyang Street, Qiantang District, Hangzhou City, Zhejiang Province Applicant after: Hangzhou Time Muscle Biotechnology Co.,Ltd. Address before: 310018 unit 08, 6 / F, building 5, No.2, kejiyuan Road, Baiyang street, Hangzhou Economic and Technological Development Zone, Zhejiang Province Applicant before: Zhejiang Yige Enterprise Management Group Co.,Ltd. |
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