CN116687815A - Composition for improving skin hydration capacity, preparation method and application - Google Patents
Composition for improving skin hydration capacity, preparation method and application Download PDFInfo
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- CN116687815A CN116687815A CN202310732765.3A CN202310732765A CN116687815A CN 116687815 A CN116687815 A CN 116687815A CN 202310732765 A CN202310732765 A CN 202310732765A CN 116687815 A CN116687815 A CN 116687815A
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- 230000037067 skin hydration Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title abstract description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 43
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- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims abstract description 18
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- 239000000047 product Substances 0.000 claims description 42
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- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of daily chemicals, and relates to a composition for improving skin hydration capacity, a preparation method and application thereof, wherein the composition comprises, by weight, 0.1-1.0 part of hyaluronic acid and derivative composition thereof, 0.1-0.5 part of ectoin, 0.5-3.0 parts of a euonymus alatus extract, 0.1-0.5 part of a lysate of a fermentation product of saccharomyces cerevisiae, 1-5 parts of glycerol, 1-5 parts of butanediol and 82-98 parts of water. The composition for improving the skin hydration capability provided by the invention can be combined with a large amount of free water and can quickly bring moisture into the skin horny layer, so that the skin hydration speed can be improved, the higher water content of the horny layer can be maintained for a long time, and the effects of moisturizing are achieved.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a composition for improving skin hydration capacity, a preparation method and application thereof.
Background
From biochemical theory, skin dryness is related to the moisture content and the moisture-retaining capacity of skin, and the moisture content of skin is determined by the hydration capacity of skin, so that the skin of a human body is in a dry and tight state due to insufficient hydration capacity of a skin stratum corneum or abnormal barrier water-retaining capacity, and has the defects of rough skin, lack of elasticity, dark luster and the like. It was found by skin moisture test experiments that coating the surface of dry, fragile skin with only one layer of lipid did not produce a skin softening effect, but even without the presence of lipid, the skin became soft and elastic as long as it was rehydrated, and it was seen that the key to improving the skin's ability to moisturize was to improve the ability to hydrate.
The existing commercially available products for moisturizing and declaring moisturizing are mainly characterized in that the moisture content of the skin is increased by adding moisturizing functional components or the moisture loss of the skin is reduced by covering with grease, and the problem of insufficient skin hydration capacity is not fundamentally solved, so that consumers often have a certain increase of the moisture content of the skin after using the products, and once the skin is stopped, the skin is turned down rapidly, namely the skin hydration capacity is not improved.
Therefore, there is a need to design products that improve the hydration capacity of the skin, i.e., to design a composition that combines with a large amount of free water and rapidly brings moisture into the stratum corneum, to increase the rate of skin hydration, and to maintain a high water content in the stratum corneum over a prolonged period of time, to provide moisturizing effects.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a composition for improving the skin hydration capability, a preparation method and application, and the specific technical scheme is as follows:
a first object of the present invention is to provide a composition for improving skin hydration ability, comprising the following components in parts by weight:
0.1-1.0 part of hyaluronic acid and derivative composition thereof, 0.1-0.5 part of ectoin, 0.5-3.0 parts of extract of dying grass, 0.1-0.5 part of lysate of fermentation product of two-split yeast, 1-5 parts of glycerin, 1-5 parts of butanediol and 82-98 parts of water.
The skin hydration improving technology is based on free diffusion and membrane protein mediated passive diffusion theory, hyaluronic acid and derivative composition thereof in the composition carry a large amount of water molecules to generate concentration gradient on the skin surface, and the concentration difference of the solute accelerates the free diffusion of the water molecules into the stratum corneum. The ectoin is an osmotic pressure compensating solute, can balance the osmotic pressure of the stratum corneum and accelerate the free diffusion rate of water molecules. The method has the advantages that the dead grass is also called as phoenix grass in south Africa, under the extreme drought condition, branches and leaves of the dead grass can be tightly contracted into spheres, each drop of water precious in the body can be firmly locked, even if the water with the self height of 98% is lost, the dead grass can still survive hard, the dead grass can be revived by only one drop of water, and the dead grass is hesitated to be regenerated; the extract of Leptoradix Glehniae can improve skin barrier water retention and reduce percutaneous water loss (TEWL) rate. The lysate is the product of metabolism, transformation or release of probiotics, and the main components comprise cell wall fragment components (such as lactic acid, short chain fatty acid and bacteriocin) of probiotics, and various amino acids, polypeptides and minerals. The lysate of the fermentation product can improve the flora distribution on the surface of the skin, and creates an ideal living environment for probiotics. The lysate is beneficial to the growth of probiotics, can indirectly inhibit the survival of harmful microorganisms, strengthen body resistance to eliminate pathogenic factors and help the skin to establish skin microecological balance; the channel protein can provide a way for water molecules to enter the stratum corneum more quickly, and most of carriers are synthesized by microorganisms, so that the function of protein water channels is improved by adding lysate of fermentation products of the saccharomyces cerevisiae. The glycerin and the butanediol have good moisture absorption effect, can absorb moisture in the air to moisten the skin, and form a water locking film on the surface of the skin. The composition improves the hydration capacity of skin through synergistic effect, and ensures that the horny layer keeps high water content for a long time, thereby achieving the aims of moisturizing and skin care.
Further, the producer of lysate of fermentation product of the Saccharomyces cerevisiae is German CLR.
Further, the preparation method of the extract of the dead grass comprises the following steps:
(1) Extracting the non-dead grass by adopting deionized water to obtain a non-dead grass extracting solution;
(2) Extracting the filter residue after filtering the extract of the dead grass for the second time, and collecting the filtrate of the second time;
(3) Concentrating the twice filtrate under reduced pressure at 55-65deg.C and 0.05-0.2MPa to obtain concentrated solution in the state of extract, adding 70-80wt% ethanol 3-4 times of the concentrated solution, stirring for 5-10min, standing for 10-14 hr, and filtering to obtain filtrate I and residue I;
(4) Concentrating the first alcohol precipitation filtrate under reduced pressure to obtain an alcohol precipitation concentrate in an extract state at 55-65deg.C and 0.05-0.2MPa, adding 90-95wt% ethanol 3-4 times the weight of the alcohol precipitation concentrate, stirring for 5-10min, standing for 10-14 hr, and filtering to obtain second alcohol precipitation residue;
(5) Spraying absolute ethyl alcohol on the alcohol precipitation filtering slag obtained in the two steps, freeze-drying, and grinding into powder, namely the extract of the dying grass.
Further, in the step (1), the grass is not killed: the weight ratio of deionized water is 1:25-35, and the extraction conditions are that the ultrasonic reflux extraction is carried out for 1.5-3h at 40-60 ℃ under 35-45W and 35-45 KHz.
A second object of the present invention is to provide a method for preparing the above composition for improving skin hydration ability, comprising the steps of:
mixing hyaluronic acid and its derivative composition with glycerol, butanediol, and water, stirring at 40-50deg.C and 60-80rpm for 3-5min, homogenizing under 80-100Mpa under high pressure, adding ectoine, extract of Isodon japonicus and lysate of fermentation product of two-split yeast, and stirring at 30-40deg.C and 300-600 rpm.
A third object of the present invention is to provide the use of said composition for improving the hydration capacity of the skin in cosmetics.
The beneficial effects of the invention are as follows:
the composition for improving the skin hydration capability provided by the invention can be combined with a large amount of free water and can quickly bring moisture into the skin horny layer, so that the skin hydration speed can be improved, the higher water content of the horny layer can be maintained for a long time, and the effects of moisturizing are achieved.
Drawings
FIG. 1 is a graph showing the results of a moisture content test of the stratum corneum of the skin according to the present invention;
FIG. 2 is a graph showing the results of the moisture content improvement rate test of the skin horny layer according to the present invention;
FIG. 3 is a graph showing the results of the skin moisture loss test of the present invention;
FIG. 4 is a scoring chart of the sensory test of the human body according to the present invention.
Detailed Description
The principles and features of the present invention are described below in connection with examples, which are set forth only to illustrate the present invention and not to limit the scope of the invention.
Example 1:
a composition for improving skin hydration ability, comprising the following components in parts by weight:
0.1 part of hyaluronic acid and derivative composition thereof, 0.1 part of ectoine, 0.5 part of dying grass extract, 0.1 part of lysate of fermentation product of two-split yeast, 1 part of glycerol, 1 part of butanediol and 97.5 parts of water.
The preparation method comprises the following steps:
mixing hyaluronic acid and its derivative composition with glycerol, butanediol, and water, stirring at 45deg.C and 70rpm for 4min, homogenizing under 100Mpa, adding ectoine, extract of herba Cynomorii and lysate of fermentation product of Saccharomyces cerevisiae, and stirring at 35deg.C and 400 rpm.
Example 2:
a composition for improving skin hydration ability, comprising the following components in parts by weight:
0.6 part of hyaluronic acid and derivative composition thereof, 0.4 part of ectoine, 1.2 parts of a dead grass extract, 0.3 part of a lysate of a fermentation product of the two-split yeast, 2 parts of glycerol, 3 parts of butanediol and 92.5 parts of water.
The preparation method is the same as that of the first embodiment, and is not repeated here.
Example 3:
a composition for improving skin hydration ability, comprising the following components in parts by weight:
1.0 part of hyaluronic acid and derivative composition thereof, 0.5 part of ectoine, 3.0 parts of a dead grass extract, 0.5 part of a lysate of a fermentation product of the two-split yeast, 5 parts of glycerol, 5 parts of butanediol and 85 parts of water.
The preparation method is the same as that of the first embodiment, and is not repeated here.
Comparative example 1:
the composition comprises the following components in parts by weight:
0.1 part of ectoine, 0.5 part of a dead grass extract, 0.1 part of a lysate of a fermentation product of the two-split yeast, 1 part of glycerol, 1 part of butanediol and 97.3 parts of water.
The preparation method is the same as that of the first embodiment, and the hyaluronic acid and the derivative composition thereof are not added correspondingly, and are not repeated here.
Comparative example 2:
the composition comprises the following components in parts by weight:
0.1 part of hyaluronic acid and derivative composition thereof, 0.5 part of a dead grass extract, 0.1 part of a lysate of a fermentation product of the saccharomyces cerevisiae, 1 part of glycerol, 1 part of butanediol and 97.3 parts of water.
The preparation method is the same as that of the first embodiment, and the corresponding method is not added with the ectoin, and is not repeated here.
Comparative example 3:
the composition comprises the following components in parts by weight:
hyaluronic acid and derivative composition thereof 0.1 parts, ectoine 0.1 parts, yeast fermentation product lysate 0.1 parts, glycerin 1 parts, butanediol 1 part and water 97.7 parts.
The preparation method is the same as that of the first embodiment, and the extract of the dead grass is not added correspondingly, and is not repeated here.
Comparative example 4:
the composition comprises the following components in parts by weight:
0.1 part of hyaluronic acid and derivative composition thereof, 0.1 part of ectoine, 0.5 part of a dying grass extract, 1 part of glycerin, 1 part of butanediol and 97.3 parts of water.
The preparation method is the same as that of the first embodiment, and the lysate of the fermentation product of the saccharomyces cerevisiae is not added correspondingly, and is not repeated here.
Comparative example 5:
the composition comprises the following components in parts by weight:
0.05 part of hyaluronic acid and derivative composition thereof, 0.1 part of ectoine, 0.5 part of a dead grass extract, 0.1 part of a lysate of a fermentation product of the two-split yeast, 1 part of glycerol, 1 part of butanediol and 97.25 parts of water.
The preparation method is the same as that of the first embodiment, and is not repeated here.
Comparative example 6:
the composition comprises the following components in parts by weight:
3 parts of hyaluronic acid and derivative composition thereof, 0.8 part of ectoine, 0.5 part of a dead grass extract, 0.1 part of a lysate of a fermentation product of the two-split yeast, 2 parts of glycerol, 2 parts of butanediol and 91.6 parts of water.
The preparation method is the same as that of the first embodiment, and is not repeated here.
The preparation method of the extract of the dead grass comprises the following steps:
(1) According to the following steps: feeding deionized water in a ratio of 1:30, and carrying out ultrasonic reflux extraction for 2h at 50 ℃ at 40W and 40 KHz;
(2) Filtering, extracting the filter residue for the second time, and collecting the filtrate for the second time;
(3) Concentrating the twice filtrate under reduced pressure at 60deg.C and 0.1MPa to obtain concentrated solution in the state of extract, adding 3.5 times of 75wt% ethanol, stirring for 5min, standing for 12 hr, and filtering to obtain filtrate I and residue I;
(4) Concentrating the first alcohol precipitation filtrate under reduced pressure to obtain an alcohol precipitation concentrate in an extract state at 60 ℃ and under the pressure of 0.1MPa, adding 95wt% ethanol which is 3.5 times of the weight of the alcohol precipitation concentrate, stirring for 5min, standing for 12h, and filtering to obtain second alcohol precipitation filter residue;
(5) Spraying absolute ethyl alcohol on the alcohol precipitation filtering slag obtained in the two steps, freeze-drying, and grinding into powder, namely the extract of the dying grass.
The lysate manufacturer of the fermentation product of the two-split yeast is Germany CLR.
To verify the effect of the composition for improving skin hydration provided by the present invention, a functional evaluation experiment was performed:
test part: left and right arm calibration area
Duration of test: 8h
1. Skin stratum corneum moisture content: corneometer CM825 was used to measure skin stratum corneum moisture content. The higher the Corn value, the higher the moisture content of the stratum corneum.
2. Skin moisture loss: tewameter (TM) 300 was used to detect skin moisture loss, and the lower the TEWL value, the less percutaneous moisture loss and the better the skin barrier function. The unit is g/(h.m) 2 )。
The product smearing area and the blank control area are randomly distributed in the left arm calibration area and the right arm calibration area of the subject. The efficacy of each sample in skin moisturization was assessed by skin stratum corneum moisture content, skin moisture loss measurements performed before, 1h after, 2h after, 4h after, 8h after the subject used the test product.
Blank test after both arms were smeared with purified water, the test was performed in the same manner as the test groups for 1h,2h,4h and 8h, respectively.
T0 (pre-use) baseline: the skin was measured directly as initial data after both arms were rinsed with purified water without using test samples.
■ Information registration (verification of identity information);
■ Reading and filling in informed consent;
■ Preliminary screening (detection of the skin at the inner side of the forearm of the two hands and confirmation of inclusion and exclusion criteria, and ending the flow if the preliminary screening is unqualified);
■ Cleaning the double arms;
■ Skin moisture content was tested by resting for 20 minutes in an environment of temperature 20.0 ℃ to 22 ℃ and humidity 40.0% rh to 60.0% rh.
T1 (1 h after use)
■ Skin moisture content was tested by resting for 20 minutes in an environment of temperature 20.0 ℃ to 22 ℃ and humidity 40.0% rh to 60.0% rh.
T2 (2 h after use)
■ Skin moisture content was tested by resting for 20 minutes in an environment of temperature 20.0 ℃ to 22 ℃ and humidity 40.0% rh to 60.0% rh.
T3 (4 h after use)
■ Skin moisture content was tested by resting for 20 minutes in an environment of temperature 20.0 ℃ to 22 ℃ and humidity 40.0% rh to 60.0% rh.
T4 (8 h after use)
■ Skin moisture content was tested by resting for 20 minutes in an environment of temperature 20.0 ℃ to 22 ℃ and humidity 40.0% rh to 60.0% rh.
The using method of the product comprises the following steps: test sample at (2.+ -. 0.1) mg/cm 2 The test area was 3 x 3cm and the sample was uniformly coated in the test area using a latex finger cuff.
Test environment: the temperature is 20.0-22 ℃, and the humidity is 40.0-60.0% RH.
3. Human body sensory test of the product: through trial of multiple groups of sensory evaluators, professional scoring evaluation of 1-15 points is carried out on dripping, continuity, thickening feeling, absorption speed and moistening feeling of trial products.
Test data:
1. the moisture content of the skin horny layer is shown in table 1 and fig. 1:
TABLE 1 results of skin stratum corneum moisture content test
The moisturizing function of skin depends mainly on two factors: first is the presence of Natural Moisturizing Factors (NMF) in the stratum corneum; secondly, a trans-epidermal water loss (TEWL) barrier formed by a lipid bilayer membrane of keratinocytes; both together determine the amount of skin hydration capacity. Sodium hyaluronate is a currently accepted natural moisturizing factor, various hyaluronic acid and derivatives thereof are added into the composition, the content of the natural moisturizing factor in a stratum corneum can be rapidly increased after the composition is used, meanwhile, the water molecule free diffusion rate can be accelerated by compounding and adding the ectopic herb extract, the transepidermal water loss (TEWL) is effectively reduced, the double-channel moisturizing is realized, and the establishment of skin microecological balance by the lysate of the fermentation product of the two-split yeast has very important synergistic effect on a protein water channel.
From experimental data, it can be seen that examples 1,2,3 and the comparative blank control group show that after the composition of the invention is applied to the skin, the moisture content of the skin is obviously improved due to the fact that the horny layer is supplemented with a large amount of natural moisturizing factors, and the moisture content data after 1h,2h,4h and 8h still keep high values, and are not obviously reduced.
The comparative examples 1,2,3 and 4 do not add one component in the composition respectively, the addition amounts of the other components are the same, although the moisture content of the comparative blank group is improved to a certain extent, the moisture content of the horny layer is still greatly different from that of the examples, and the moisture content data after 1h,2h,4h and 8h are obviously reduced, so that the capability of improving the skin moisture content of the comparative examples is insufficient, and the composition has reasonable component compounding and obvious synergistic effect.
Comparative example 1, without addition of hyaluronic acid and its derivatives, shows that skin moisture content is lower than comparative examples 2,3,4, indicating that hyaluronic acid and its derivatives play a major role in increasing skin moisture content; although the comparative example 2 is free of the addition of the ectoine, compared with the examples, the addition of the hyaluronic acid and the derivatives thereof is greatly improved, the skin water content is still greatly different from the examples, and the ectoine has obvious improvement effect on accelerating the free diffusion rate of water molecules and assisting the percutaneous absorption of natural moisturizing factors; comparative example 3, in which no dead grass extract was added, showed a remarkable reduction in skin moisture content compared to comparative examples 2,2h-8h, indicating that the dead grass extract significantly reduced the percutaneous moisture loss rate (TEWL), and the water-retaining and water-retaining effects were prominent; comparative example 4, in which no lysate of the fermentation product of Saccharomyces cerevisiae was added, showed a great difference in skin moisture content from the examples, although the addition amount of hyaluronic acid and its derivatives was greatly increased as compared with the examples, indicating that the addition of lysate of the fermentation product of Saccharomyces cerevisiae had a synergistic effect in improving hydration.
The composition of comparative example 5 adopts the same components, but reduces the addition amount of hyaluronic acid and derivatives thereof, and compared with comparative examples 1,2,3 and 4, the data are improved to a certain extent, and the skin moisture content of 1h,2h and 4h reflects reasonable composition of the invention from the side. Compared with examples 1,2 and 3, the data still have larger differences, which indicates that the adding proportion of each component of the examples is reasonable in design.
Comparative example 6, in which the addition amount of hyaluronic acid and its derivatives was increased based on the addition ratio of each component of the examples, but the skin moisture content was still lower than that of the examples, shows that although the addition amount of hyaluronic acid and its derivatives had an obvious effect on improving the skin moisture content, the improvement effect on skin hydration was still not obvious if the composition ratio was not designed reasonably.
2. The moisture content improvement rate of the skin horny layer is shown in table 2 and fig. 2:
TABLE 2 results of skin horny layer moisture content improvement test
The data in table 2 and fig. 2 reflect the apparent effect of the examples in enhancing skin hydration by moisture content improvement rate based on skin stratum corneum moisture content, compared to baseline T0 (prior to use). It can be seen from the graph that the skin moisture improvement rates of examples 1,2 and 3 reached 80% or more after 1 hour of use, and 53.4% at the highest in the comparative example. Meanwhile, the skin moisture improvement rate of the examples still keeps higher data along with the service time, but the improvement rate of the comparative examples is obviously reduced along with the time, and even is negative after 8 hours. It can be seen that the composition of the present invention has a significant effect in improving skin hydration by the design of the components and amounts added.
3. The skin moisture loss values are shown in table 3 and fig. 3:
TABLE 3 skin moisture loss test results table
The rate of transcutaneous moisture loss (TEWL) is another major factor affecting hydration, which must be affected if only skin moisture content is increased without improving TEWL. As can be seen from the graph, examples 1,2 and 3 show a rapid decrease in TEWL after use, while comparative examples 1-6 show a significant difference from the examples in improving TEWL, and after 1h the TEWL again begins to rise, failing to achieve a durable water-and water-retaining effect, thus demonstrating that the compositions of the invention have a significant effect in reducing TEWL.
4. The human sensory test of the product is shown in fig. 4:
when the cosmetic is designed in a formula, not only the improvement of test data is considered, but also the skin feel experience of consumers in the use process is important, the excellent skin feel can be achieved only by reasonable formula component design, and whether the skin hydration effect is improved can be reflected by human body sensory test data.
1) The dripping is to test the flowability of the piled test products for 15 minutes, simulate the flowing characteristics of the products at the back of hands in the using process, and is unfavorable for the use of the products if the products slide too fast. The lower this score, the better the test data.
2) The continuity is a continuous phase state formed by the test product after the product is pushed away on the skin surface once, and the data can measure the spreadability of the product, and the good spreadability is helpful for improving the absorption speed of the product. The higher this score, the better the test data.
3) The sense of thickness is the texture of the test product, including the consistency, viscosity, etc., and the skin feel during the trial of the test sample is compared, and the score is centered, indicating that the better the test data.
4) The absorption speed is the time required for the test product to be completely absorbed after the test product is coated on the skin surface and the finger belly is coated in a looping way. The higher this score, the better the test data
5) The moist feeling refers to the evaluation of the feeling of skin elasticity, softness, wettability and the like after the test article is applied to the skin surface for absorption. The higher this score, the better the test data.
As can be seen from the human sensory test scoring graph of FIG. 4, the three test indexes of the examples 1,2 and 3, namely the continuity, the absorption speed and the moistening property, are highest in score, the consistency score is middle, and the dripping score is low, so that the composition is reasonable in design and suitable in skin feel.
In summary, the composition for improving the skin hydration ability provided by the invention can be combined with a large amount of free water, can quickly bring moisture into the stratum corneum of the skin, can promote the skin hydration speed, can maintain the higher moisture content of the stratum corneum for a long time, and has remarkable effects on moisturizing.
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and scope of the invention are intended to be included within the scope of the invention.
Claims (5)
1. A composition for improving the hydration capacity of the skin, comprising the following components in parts by weight:
0.1-1.0 part of hyaluronic acid and derivative composition thereof, 0.1-0.5 part of ectoin, 0.5-3.0 parts of extract of dying grass, 0.1-0.5 part of lysate of fermentation product of two-split yeast, 1-5 parts of glycerin, 1-5 parts of butanediol and 82-98 parts of water.
2. The composition for improving skin hydration ability of claim 1, wherein said method for preparing said extract of euonymus alatus comprises the steps of:
(1) Extracting the non-dead grass by adopting deionized water to obtain a non-dead grass extracting solution;
(2) Filtering the extract of the dead grass, extracting filter residues for the second time, and collecting filtrate for the second time;
(3) Concentrating the filtrate under reduced pressure at 55-65deg.C and 0.05-0.2Mpa to obtain concentrated solution in the state of extract, adding 70-80wt% ethanol 3-4 times of the concentrated solution, stirring for 5-10min, standing for 10-14 hr, and filtering to obtain filtrate I and residue I;
(4) Concentrating the first alcohol precipitation filtrate under reduced pressure to obtain an alcohol precipitation concentrate in an extract state at 55-65deg.C and 0.05-0.2Mpa, adding 90-95wt% ethanol 3-4 times the weight of the alcohol precipitation concentrate, stirring for 5-10min, standing for 10-14 hr, and filtering to obtain second alcohol precipitation filtrate residue;
(5) Spraying absolute ethyl alcohol on the alcohol precipitation filtering slag obtained in the two steps, freeze-drying, and grinding into powder, namely the extract of the dying grass.
3. The composition for improving skin hydration ability of claim 2, wherein in said step (1), the grass is killed: the weight ratio of deionized water is 1:25-35, and the extraction conditions are that the ultrasonic reflux extraction is carried out for 1.5-3h at 40-60 ℃ under 35-45W and 35-45 KHz.
4. A method of preparing a composition for improving the hydration capacity of the skin according to any one of claims 1 to 3, comprising the steps of:
mixing hyaluronic acid and its derivative composition with glycerol, butanediol, and water, stirring at 40-50deg.C and 60-80rpm for 3-5min, homogenizing under 80-100Mpa under high pressure, adding ectoine, extract of Isodon japonicus and lysate of fermentation product of two-split yeast, and stirring at 30-40deg.C and 300-600 rpm.
5. Use of a composition for improving the hydration capacity of the skin according to any one of claims 1 to 3 in cosmetics.
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