CN107411997A - A kind of anti-aging face cream composition - Google Patents
A kind of anti-aging face cream composition Download PDFInfo
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- CN107411997A CN107411997A CN201710495357.5A CN201710495357A CN107411997A CN 107411997 A CN107411997 A CN 107411997A CN 201710495357 A CN201710495357 A CN 201710495357A CN 107411997 A CN107411997 A CN 107411997A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of anti-aging face cream composition.The anti-aging face cream of the present invention contains nonapeptide 1, the bronze medal of tripeptides 1, acetyl group octapeptide 3 and palmityl tripeptides 5.Nonapeptide 1 can desalinate color spot, bright color, improve the low and deep phenomenon of complexion；The bronze medal of tripeptides 1 can not only reduce light injury and color spot, bright color, and can take-up slack skin, improve elasticity, density, degree of compacting and the definition of skin, reduce microgroove and deep wrinkle, greatly increase the propagation of horn cell；Acetyl group octapeptide 3 can be reduced due to around deep wrinkles, particularly forehead caused by facial expression muscle contraction and eyes；Palmityl tripeptides 5 can reduce any kind of wrinkle in the synthesis of people's fibrocyte moderate stimulation collagen.It is applied in combination in the face cream product of anti-aging, the small microgroove that the dark yellow colour of skin, skin are begun to show is significantly improved, mitigation, which can also be desalinated, persistently has laugh line, dry line, decree line of depth etc., and just old and aging skin all obtains a certain degree of improvement, and senile-resistant efficacy is clearly visible.
Description
Technical field
The invention belongs to cosmetic field, is related to a kind of peptide composition containing anti-aging, has and mitigates the dark of skin
Huang, bright color, small microgroove is smoothed, mitigate the anti-aging face cream composition of the multiple action of deep wrinkles and decree line.
Background technology
People has arrived certain age, partes corporis humani divides the function of histoorgan slowly decaying, in addition environmental pollution
Be on the rise, modern's health care consciousness general lack of, life famine it is regular and because caused by operating pressure excessively
Fatigue etc. so that we have difficulties at home and abroad, immunity degradation, so as to be faced with the harsh reality for stepping into aging too early.Aging is raw
The natural law of development is ordered, as long as life remains, aging is irreversible and stopped.
From ancient times to the present, people, which thirst for keeping the heart of young appearance here, never stopped.With the development of the society, material and culture is given birth to
The flat raising of running water, people also pursue personalized health, as appearance is pretty and charming, curve on the basis of it is desirable that obtaining holistic health
Exquisite, perpetual youth etc..In order to resist aging, present businessmans be consumer it is customized go out various anti-aging vocabulary,
Such as remain youthful forever, perpetual youth, preserve youthful looks, multiple face, freeze age, etc..Nowadays, it is more than the women that likes to be beautiful, males are also increasingly
Thirst for keeping here the appearance of youth, or slowly can go always.
According to literature survey, 2009~2014, high-end skin care item troughput was expected to be 2,600,000,000 dollars, was equal to whole
The 40% of high-end beauty industry absolute increase, and this main driving factors is then strong need of the Asian market to anti-aging product
Ask, especially demand of the China to anti-aging product.In western market, such as in the U.S., the attention ratio that people give to anti-aging
Other beauty and personal care product will be more, and many consumers are firm in the view that, there is contact between price and effect, because
This, the sale of high-end anti-aging product is always maintained at relatively vigorous.
Although in terms of the positioning for older consumer, China lags behind other mature markets, in aging ingredient
Use on Asia be then in the forefront in market.In China, although anti-aging product was only limitted to disappear for more than 50 years old in the past
Fei Zhe, but at present just by one's late 30s, or even the favor of younger consumer.Become from Mintel global new product development
Gesture can see, and in China and this Japanese 2 staple markets, have the new product showed increased of anti-senescence function.Although method
The market such as state and the U.S. remains ahead on new product sum, but the growth rate of the new product development of China and Japan is most fast
's.The Chinese and Japanese fastest-rising promoting factor of new product development is that first, China is increasingly plentiful, and consumer is increasing, promotees
Enter the paces that manufacturer accelerates innovation, the expansion in market attracts to carry out more funds, and native country manufacturer starts to protect its market
Share, exempt from the segmentation of internationally renowned brand；Secondly, Chinese manufacturer uses new component, these new components more and more
It is to be extracted from conventional medicament and vegetable drug mostly, and these medicinal materials are always the composition approved by Asian culture for a long time
Part.On the basis of consumer is catered to, the concept of many new raw materials is declared to be applied in the theme skin care of anti-aging.
Considered for cost with what is sold, anti-aging product majority on the market is based on concept, possesses actual efficacy
It is seldom, and with remarkable efficacy polypeptide anti-aging skin care product it is even more few.Consumer often also values science effect
Record, and do not mind the price of product, many consumers are ready to pay anti-ageing cosmetics for anti-aging.Cause
This, skin care item simply claim with anti-senescence function to be often inadequate.For cosmetician, there is obvious effect
Anti-aging skin care product have become the new lover of personal care articles in the market because consumer wants to keep young appearance.Not
Come, the growth in skin type product market will continue to be driven by anti-aging product.
Skin aging is the external manifestation of human senility, is due to endogenous and the composite factor such as exogenous is coefficient
As a result.With advancing age, the aging of skin is more and more obvious, be mainly shown as dry skin, coarse, wrinkle, tarnish,
Nonelastic, pale and relaxation, or even there is atrophoderma, crowfoot cracks and senile plaque expelling etc..Sunlight or other environmental factors also can
Cause skin senescence and impaired, reduction skin activity.The aging of skin not only have impact on the appearance and image of human body, but also sternly
The physiological function of human body skin is hampered again, or even the pathology that also skin can be caused serious sexually revises.
Polypeptide is a-amino acid with the compound that peptide bond links together and is formed, and it is also the centre of protein hydrolysis
Product.The compound formed by two amino acid molecular dehydrating condensations is called dipeptides, similarly analogizes also tripeptides, tetrapeptide, pentapeptide
Deng.The compound generally formed by three or more than three amino acid molecular dehydrating condensations, which can turn into, is polypeptide.
Biologically active polypeptide is the optimum activity composition of skin nursing, can control or adjust skin aging process, protection
Damaged skin, delay skin aging, the 26S Proteasome Structure and Function to keeping normal skin, maintain normal physiological activity and the metabolism of body
It is significant.
The effect of biologically active polypeptide is：1. on epidermis level, the activity and growth factor of keratinocyte are influenceed, is stimulated
Keratinocyte migration and epithelialization, stimulate epidermal cell to break up and correct, strongly facilitate epidermis reparation and healing；2. in corium water
On flat, fibroblasts are stimulated, enhancing extracellular matrix shrinks and construction, there is provided skin Nutrients uptake skin wound healing
And functional regeneration；3. in skin integral level, strengthen to environmental assaults, ultraviolet, pollutant, stimulant, sensitizer and inflammation
Property cell resistance, consolidate, enhancing skin tensor muscle, strengthen skin elasticity, stimulate scar tissue fade, reduce cicatrization,
Delay skin aging.
In order to provide the anti-aging skin care product for being more than new ideas to consumer, but possess the product of actual efficacy, I
Develop the polypeptide anti-aging skin care product composition for possessing prominent effect, and its preparation method of face cream.
At present, in the industry there is not yet the anti-of nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and palmityl tripeptides -5 is applied in combination
Aging face cream.
The content of the invention
It is an object of the invention to provide a kind of peptide composition face cream for possessing senile-resistant efficacy, and no matter skin is just old
State is still compared with the aging of depth, even in the state of there is not aging, face cream prepared by said composition can be preferable
Ground, which is resisted, mitigates aging or pre- anti-aging.
Above-mentioned purpose of the present invention is achieved by the following technical programs：
A kind of anti-aging face cream composition of the present invention, comprising by nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and palm
The anti-apolexis composition that acyl tripeptides -5 forms.Wherein, nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and the weight of palmityl tripeptides -5
Measuring percentage is：
Percentage by weight of the nonapeptide -1 in whole system is 0.0001%-0.002%；It is preferred that 0.0001%-
0.001%；Percentage by weight of the copper of tripeptides -1 in whole system is 0.01%-0.5%；It is preferred that 0.02%-0.3%；Acetyl
Percentage by weight of the base octapeptide -3 in whole system is 0.001%-0.01%；It is preferred that 0.002%-0.01%；Palmityl three
Percentage by weight of the peptide -5 in whole system is 0.001%-0.025%；It is preferred that 0.001%-0.02%；The present composition
The anti-aging face cream of preparation has good anti-aging effects.
The percentage by weight of nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and palmityl tripeptides -5 in whole system, more
For preferably, respectively 0.0002%-0.001%, 0.05%-0.2%, 0.002%-0.005%, 0.001%-0.01%；
Most preferably, the weight hundred of the nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and palmityl tripeptides -5 in whole system
Point ratio 0.001%, 0.2%, 0.005%, 0.005%.
At this point it is possible to obtain the optimal anti-aging effects of cost performance, the senile symptom of skin is significantly improved, wrinkle
Disappear or reduce, the elasticity and the degree of packing of skin are also embodied well, while bright color.
Composition of the present invention, hydrophilic NMF and the oleophylic emollient containing more moisturizing, moisture-keeping function.
The hydrophilic NMF is selected from：Glycerine, butanediol, propane diols, 1,3-PD, glycine betaine, Sodium Hyaluronate, oneself
It is several in glycol, pentanediol, Anjidew NL50, trehalose, polyquaternium -51, sorb (sugar) alcohol；
Preferably glycerine, 1,3-PD, five kinds of butanediol, glycine betaine, Sodium Hyaluronate combinations.
Wherein, glycerine and 1,3-PD compounding can significantly increase moisturizing power；Butanediol is also gentle polyalcohol moisturizing
Agent, there is good dispersiveness and compatibility；Glycine betaine can not only provide superior skin sense as NMF, additionally aid product
Stability；Sodium Hyaluronate is one of composition of human body skin, is the acid glutinous sugar of one kind that distribution is most wide in human body, is present in
In the matrix of connective tissue, there is good moisture-keeping function.In this five kinds of NMFs, glycerine, 1,3-PD, butanediol can
As the excellent dispersants of Sodium Hyaluronate, it to be easy to preferably soluble in water, dissolubility of the glycine betaine in water is fine, they that
This synergy, can obtain more preferable moistening effect.
Percentage by weight of the currently preferred replenishing water and preserving moisture agent in whole system is respectively glycerine 1-15%, and 1,3- third
Glycol 1-15%, butanediol 1-10%, glycine betaine 0.5-5%, Sodium Hyaluronate 0.001-0.2%.
In addition to above-mentioned necessary component, in the range of the effect of the present invention is not damaged, the present composition further also wraps
Containing following components in percentage by weight：
Emulsifying agent 1-4%, thickener 0.1-3%, emollient 5-20%, NMF 1-10%, pH adjusting agent 0.06-
0.6%th, aromatic 0.05-0.2%, chelating agent 0.03-0.1%, preservative 0.1-2%, deionized water To 100%.
The concrete example of the composition described below coordinated：
As primary emulsion, the distearate of polyglycereol -6, tribehenin essence PEG-20 esters, cetearyl Portugal can be used
Glucosides, the methyl of polyglycereol -3 distearate, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb etc..
As assistant for emulsifying agent, polysorbate -20, stearine, PEG-100 stearates, cocoyl can be used
Glucoside, polyacrylamide, C13-14 isoparaffins, laureth -7, PAA/sodium acryloyldimethyl taurate are common
Polymers, Polyoxyethylene Sorbitan Monooleate etc..
As thickener, cetostearyl alcohol, beeswax, stearic acid etc. can be used in oil phase；Carbomer, xanthan can be used in aqueous phase
Glue, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters are handed over
Linked polymer, AVC.
As emollient, can be used Butyrospermum parkii fruit fat, saualane, tocopherol acetate, ring five dimethyl silicone polymer,
Octyl group polymethyl siloxane, carbonic acid dioctyl ester, Permethyl 99A, caprylic/capric triglyceride, dimethyl silicone polymer, C10-18
Resin acid triglyceride, Parleam, ethylhexyl palmitate, pentaerythritol tetraoctyl stearate, polydimethylsiloxanes
Alkane cross-linked polymer, Dimethicone/Vinyl Dimethicone cross-linked polymer, dimethiconol
Deng.
As NMF, glycerine, propane diols, butanediol, 1,3-PD, glycine betaine, Sodium Hyaluronate, xylose can be used
Alcohol, sorbierite.
As pH adjusting agent, aminomethyl propanol, sodium hydroxide, potassium hydroxide, arginine, triethanolamine etc. can be used.
As aromatic, all kinds of fragrance of a flower, fruity, flowers and fruits perfume, banksia rose etc. can be used.
As chelating agent, EDETATE SODIUM, the sodium of EDTA tetra- etc. can be used.
As preservative, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, phenmethylol, sodium benzoate, potassium sorbate can be used
Deng, sour sodium etc. in anisic acid, acetyl.
Anti-aging face cream composition of the present invention, available for various effect type anti-aging faces containing anti-apolexis composition of preparation
Frost.
The effect of of the invention, the anti-aging face cream composition of type had following beneficial effect：
1) nonapeptide -1 suppresses the formation of melanin, desalinates color spot, reduces pigmentation.
2) tripeptides -1 it is copper-promoted enter scar outside a large amount of Collagen accumulation things degradeds, promote the normal collagen of skin, bullet
The generation of power albumen, proteoglycans and grape amine glycan, promote growth and anti-inflammatory, the Antioxidation reaction of different cell types, carry
High skin elasticity and compactness, and reduce the skin problems such as wrinkle depth, color spot.It can also increase angiogenic growth and antioxygen
Change ability, and stimulate glucose polyamine to produce, the ability for helping skin to recover self-healing.
3) acetyl group octapeptide -3 can be reduced due to deep wrinkles, particularly forehead and eye caused by facial expression muscle contraction
Around eyeball；
4) palmityl tripeptides -5 can reduce any kind of wrinkle in the synthesis of people's fibrocyte moderate stimulation collagen.
5) anti-aging face cream provided by the invention moisten, moisturizing while, there is provided preferable anti-aging effects, that is, desalinate
With dark yellow, the bright color for mitigating deep wrinkles, elimination microgroove and skin, improve just old and Time fleets past aging state.
Brief description of the drawings
The effect of Fig. 1 is test group and blank control evaluation index contrasts.
Embodiment
The invention provides a kind of anti-aging face cream of the peptide composition containing senile-resistant efficacy, contain nonapeptide -1, three
The copper of peptide -1, acetyl group octapeptide -3 and palmityl tripeptides -5.
On the one hand, suppress the formation of melanin by nonapeptide -1, desalinate color spot, reduce pigmentation.Melanocortin -1
Acceptor plays a crucial role in cutaneous pigmentation, after being embodied in the acceptor of casting skin matter peptide combination melanocortin -1, activates adenylate
Cyclase, then causes intracellular cAMP to increase, and the increased further activated protein kinase Cs of cAMP are final by protein kinase C
Activate tyrosinase.Nonapeptide -1 reduces the knot of the two by competing its acceptor of native ligand melanocortin -1 with melanocortin peptides
Conjunction rate, so as to block the activation of tyrosinase, suppress the generation of melanin, reduce the excessive calmness of melanin, bright color.
On the other hand, by tripeptides -1 it is copper-promoted enter scar outside a large amount of Collagen accumulation things degrade, promote skin normal
The generation of collagen, elastin, proteoglycans and grape amine glycan, promote the growth of different cell types and anti-inflammatory, anti-
Oxidation reaction, skin elasticity and compactness are improved, and reduce the skin problems such as wrinkle depth, color spot.It can also increase blood
Pipe grows and oxidation resistance, and stimulates glucose polyamine to produce, the ability for helping skin to recover self-healing.
Furthermore repaired by the way that -3 pairs of skins of acetyl group octapeptide are further.Acetyl group octapeptide -3 is as a kind of crease-resistant
Octapeptide, its anti-wrinkle effect are better than Argireline, are based on modern biochemical mechanism and the antiwrinkle active raw material polypeptide of scientific and reasonable design,
Its effect can match in excellence or beauty with botulinum toxin type A.Cause contraction of muscle after the neurotransmitter that muscle receives to discharge in vesica,
SNARE compounds are played an important role in synaptic neurotransmitter release, and the compound is linked up with just as a cell, can be captured
Vesica simultaneously merges so as to release neurotransmitters with its film.Acetyl group octapeptide -3 is the analogies of SNAP-25 N- ends end, is participated in
Competition SNAP-25 is melting the site of bubble complex, so as to influence the formation of complex.If melt bubble complex slightly to disturb, capsule
Bubble can not effective release neurotransmitters, it will cause contraction of muscle to weaken, so as to prevent the formation of wrinkle.
Finally, carried out by -5 pairs of skins of palmityl tripeptides comprehensive crease-resistant, any kind of wrinkle can be reduced.It is clinical
Experiment display, palmityl tripeptides -5 can reduce and change the type and size of wrinkle with age.Skin aging is outstanding
It is the decline that lasting ultraviolet irradiation can cause skin, shows as the obvious change of the composition of dermal extracellular matrix (ECW),
Result is to result in the increase of skin fragility, the increase of keratin skin appearance and wrinkle.Collagen is skin connective tissue
(ECW) main component.Thrombospondin I (TSP) is a multifunctional protein, and it is inactive that it can activate potential biology
TGF-β (tissue growth factor).TGF-β has the function that important in collagen synthesis.TSP answers with inactive TGF-β
The fragment sequence Arg-Phe-Lys of compound is combined, and active TGF-β is generated so as to induce.Therefore with activation TGF-β ability
Small molecule can turn into the ideal product of effective wrinkle reparation, so as to accelerate the formation of new collagen.Palmityl tripeptides-
5 have specific sequence similar to human body body self mechanism, and collagen is produced by TGF-β.Therefore, palmityl tripeptides -5
The supplement that can be lacked as skin collagen, so that skin is younger.
It is a discovery of the invention that nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and palmityl tripeptides -5 are applied in combination, it is used for
In the face cream product of anti-aging, the small microgroove that the dark yellow colour of skin, skin are begun to show is significantly improved, moreover it is possible to which desalination mitigates lasting
There are laugh line, dry line, decree line of depth etc., just old and aging skin all obtains a certain degree of improvement, and senile-resistant efficacy is
It is evident that.
Technical scheme, embodiment not generation are further illustrated below by way of specific embodiment combination effete test embodiment
Table limiting the scope of the present invention.Some nonessential modifications and adjustment that other people make according to protection conception of the present invention
Still fall within protection scope of the present invention.Following percentage is weight percentage.
Embodiment 1
A kind of formula 1 of anti-aging face cream composition is as shown in table 1 below.
The embodiment 1 of table 1 and comparative example anti-aging face cream formula
The anti-aging face cream composition its preparation method of embodiment 1 can be expressed as follows：
1) oil phase 1 is heated to 80~85 DEG C in oil phase pot, adds oil phase 2 before emulsifying, be incubated 10min；
2) aqueous phase is heated to 80~85 DEG C in aqueous phase pot, stirring is, untill being completely dissolved；
3) emulsify pot preheating to be evaporated, draw water and mutually enter to emulsify pot, reserved part aqueous phase rinses oil phase pipeline；
4) under quick stirring and homogeneous state, oil phase is pumped into emulsification pot, phase of drawing water flushing pipe, 3000rpm homogeneous
4min, then cool down while stirring；
5) 60 DEG C when add other 1, the stirring cooling of homogeneous 2min, 600rpm rotating speed；
6) when being cooled to 43 DEG C, the other each phases for including being uniformly dissolved is added, are stirred, being down to 36 DEG C can discharge.
Embodiment 2
A kind of formula 2 of anti-aging face cream composition is as shown in table 2 below.
The anti-aging face cream formula of 2 embodiment of table 2
The preparation method of the anti-aging face cream composition of embodiment 2 is the same as embodiment 1.
Embodiment 3
A kind of formula 3 of anti-aging face cream composition is as shown in table 3 below.
The anti-aging face cream formula of 3 embodiment of table 3
The preparation method of the anti-aging face cream composition of embodiment 3 is the same as embodiment 1.
Embodiment 4
A kind of formula 4 of anti-aging face cream composition is as shown in table 4 below.
The anti-aging face cream formula of 4 embodiment of table 4
The preparation method of the anti-aging face cream composition of embodiment 4 is the same as embodiment 1.
Embodiment 5
A kind of formula 5 of anti-aging face cream composition is as shown in table 5 below.
The anti-aging face cream formula of 5 embodiment of table 5
The preparation method of the anti-aging face cream composition of embodiment 5 is the same as embodiment 1.
It is effete test embodiment content below.
Efficacy assessments determine
1st, test purpose：
In order to test effect of the composition in the anti-aging face cream of different ratio, will respectively contain as table 1, table 2, table 3,
The anti-aging face cream of nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and the composition of palmityl tripeptides -5 that table 4, table 5 match, allows
Trier tests, and remaining component is identical with comparative example.
2nd, subjects：At 25~50 years old, there are skin care item at age using the volunteer 30 of experience, finally obtains effectively anti-
30 parts of feedback.
3rd, method of testing：Please the trier anti-aging face cream of 5 kinds of different ratios on probation and the face cream of comparative example, and root successively
Given a mark according to result on trial.
4th, standards of grading：3 points, hence it is evident that improve；2 points, improve to a certain degree；1 point, no improvement.
The marking result of 30 triers is taken to be averaged, finally giving the evaluation result of table 6 below, (total score is higher, then skin lightening
Anti-aging effects are better).
The anti-aging face cream and comparative example face cream of the different ratio of table 6 and trier's subjectivity use efficacy assessments
As shown in Table 6, when nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and palmityl tripeptides -5 are in whole anti-aging face
When percentage by weight in white system incrementally increases, skin lightening and anti-aging effects further significantly improve.
It is the most prominent, when nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -3 and palmityl tripeptides -5 are in whole anti-aging
When percentage by weight in face cream system is respectively 0.001%, 0.2%, 0.005% and 0.005%, it can obtain optimal bright
Skin, anti-aging effects, and cost performance is optimal.
As shown in figure 1, the degree that skin is improved is related to the amount of the polypeptide anti-apolexis composition of addition.With addition
The increase of amount, skin senescence situation be improved significantly tester's number correspondingly increase；And with the reduction of addition, skin
Skin aging aspects correspondingly increase without improved tester's number.
To sum up illustrate, in system of the invention specific, from preferred proportion nonapeptide -1, the copper of tripeptides -1, acetyl group octapeptide -
3 and palmityl tripeptides -5, the splendid anti-aging face cream of anti-aging effects can be obtained.It compensate for anti-aging effects in the prior art
The problem of being confined to declare aspect.
The above described is only a preferred embodiment of the present invention, any formal limitation not is made to the present invention, therefore
It is every without departing from technical solution of the present invention content, what the technical spirit according to the present invention was made to above example any simply repaiies
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (7)
- A kind of 1. anti-aging face cream composition, it is characterised in that：By weight, comprising following anti-apolexis composition：Account for total composition 0.0001%-0.002% nonapeptide -1；Account for the total composition 0.01%-0.5% copper of tripeptides -1；Account for total composition 0.001%-0.01% acetyl group octapeptide -3；Account for total composition 0.001%-0.025% palmityl tripeptides -5.
- 2. anti-aging face cream composition as claimed in claim 1, it is characterised in that：By weight, comprising following anti-ageing Old composition：Account for total composition 0.0001%-0.001% nonapeptide -1；Account for the total composition 0.02%-0.3% copper of tripeptides -1；Account for total composition 0.002%-0.01% acetyl group octapeptide -3；Account for total composition 0.001%-0.02% palmityl tripeptides -5.
- 3. anti-aging face cream composition as claimed in claim 1, it is characterised in that：By weight, comprising following anti-ageing Old composition：Account for total composition 0.0002%-0.001% nonapeptide -1；Account for the total composition 0.05%-0.2% copper of tripeptides -1；Account for total composition 0.002%-0.005% acetyl group octapeptide -3；Account for total composition 0.001%-0.01% palmityl tripeptides -5.
- 4. anti-aging face cream composition as claimed in claim 1, it is characterised in that：By weight, comprising following anti-ageing Old composition：Account for the nonapeptide -1 of total composition 0.001%；Account for the copper of tripeptides -1 of total composition 0.2%；Account for the acetyl group octapeptide -3 of total composition 0.005%；Account for the palmityl tripeptides -5 of total composition 0.005%.
- 5. anti-aging face cream composition as claimed in claim 1, it is characterised in that：Further also contain following weight percent The component of ratio：Emulsifying agent 1-4%, thickener 0.1-3%, emollient 5-20%, NMF 1-10%, pH adjusting agent 0.06-0.6%, virtue Pastil 0.05-0.2%, chelating agent 0.03-0.1%, preservative 0.1-2%, deionized water To 100%.
- 6. anti-aging face cream composition as claimed in claim 5, it is characterised in that：The emulsifying agent is the distearate of polyglycereol -6, tribehenin essence PEG-20 esters, cetearyl glucoside, poly- sweet One or more of groups in oily -3 methyl distearates, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb Close；Further, also contain assistant for emulsifying agent, be polysorbate -20, stearine, PEG-100 stearates, cocounut oil Base glucoside, polyacrylamide, C13-14 isoparaffins, laureth -7, PAA/sodium acryloyldimethyl taurate One or more combination in copolymer, Polyoxyethylene Sorbitan Monooleate；The thickener, oil phase are the one or more combination in cetostearyl alcohol, beeswax, stearic acid；Aqueous phase is carbomer, Huang Virgin rubber, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters One or more combination in cross-linked polymer, AVC；The emollient is Butyrospermum parkii fruit fat, saualane, tocopherol acetate, ring five dimethyl silicone polymer, the poly- first of octyl group Radical siloxane, carbonic acid dioctyl ester, Permethyl 99A, caprylic/capric triglyceride, dimethyl silicone polymer, C10-18 resin acid glycerine Three esters, Parleam, ethylhexyl palmitate, pentaerythritol tetraoctyl stearate, dimethyl silicone polymer crosslinking are poly- Compound, Dimethicone/Vinyl Dimethicone cross-linked polymer, one kind in dimethiconol or Several combinations；The NMF is glycerine, propane diols, butanediol, 1,3- propane diols, glycine betaine, Sodium Hyaluronate, xylitol, sorbierite In one or more combination；The pH adjusting agent is the one or more in aminomethyl propanol, sodium hydroxide, potassium hydroxide, arginine, triethanolamine Combination；The aromatic is the one or more in the fragrance of a flower, fruity, flowers and fruits perfume, the banksia rose；The chelating agent is one or both of EDETATE SODIUM, the sodium of EDTA tetra-；The preservative is methyl hydroxybenzoate, Nipasol, Phenoxyethanol, phenmethylol, sodium benzoate, potassium sorbate, anisic acid, second One or more combination in acyl in sour sodium.
- 7. the anti-aging face cream composition described in any one of claim 1-6, it is characterised in that：It is preparing anti-aging face The application in all skin-protection products outside frost.
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| CN108619047A (en) * | 2018-06-04 | 2018-10-09 | 广州奥蓓斯化妆品有限公司 | A kind of cosmetic formulations of anti-aging and preparation method thereof |
| CN108420776A (en) * | 2018-06-07 | 2018-08-21 | 花安堂生物科技集团有限公司 | A kind of essence composition and the re-surface intensive wrinkle correct and preparation method thereof that compacts being made from it |
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| CN110711165A (en) * | 2019-11-03 | 2020-01-21 | 上海悦目化妆品有限公司 | Anti-aging firming beauty cream containing kangaroo paw extract |
| CN111671716A (en) * | 2020-07-22 | 2020-09-18 | 广州蛋壳网络科技有限公司 | Antioxidant skin color brightening composition and application thereof in cosmetics |
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| CN113952248B (en) * | 2021-08-26 | 2023-07-11 | 无限极（中国）有限公司 | Polypeptide composition and application thereof |
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