CN110302133A - A kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract - Google Patents
A kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract Download PDFInfo
- Publication number
- CN110302133A CN110302133A CN201910768015.5A CN201910768015A CN110302133A CN 110302133 A CN110302133 A CN 110302133A CN 201910768015 A CN201910768015 A CN 201910768015A CN 110302133 A CN110302133 A CN 110302133A
- Authority
- CN
- China
- Prior art keywords
- leech
- mucus
- extract
- component
- facial mask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to facial mask liquid and preparation fields, more specifically to a kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract.The Regeneration and Repair facial mask liquid mainly includes following raw material: glycerol, reed fragrant plant oil, esters of acrylic acid/carbon 10-30 alkylol acrylamide acid esters cross-linked polymer, leech mucus extract, purslane extract, Japanese elm root extract, star anise oil etc..The preparation method includes: to be heated to being completely dissolved by component A；It is added after each raw material mixing of B component and extremely transparent；Temperature is evenly stirred until semi-transparent lotion to the component C mixed is added after 30 DEG C~50 DEG C；Put into D component, after mixing evenly deaeration, discharging.The present invention can help improve sensitive skin, mildly can effectively inhibit whelk, acne, acne, obscure appearance, have positive effect to preventing and improving scar, can effectively accelerate cytothesis, promote healing, repair impaired skin, the aging of delaying skin.
Description
Technical field
The present invention relates to facial mask liquid and its preparation field is repaired, extracted more specifically to a kind of application leech mucus
Regeneration and Repair facial mask liquid of object and preparation method thereof.
Background technique
The quasi- doctor leech of hiruto (Poecilobdella manillensis) alias horse Buddhist nun, is commonly called as phnom penh leech, has very high
Medical value, propagate artificially very convenient, be the biggish kind of individual in current common class leech of sucking blood, at this stage to luxuriant and rich with fragrance ox
The research of leech focuses mostly in terms of cultivation, anticoagulant antithrombotic acitivity component extraction separation and pharmacological action, and about leech skin
The type and its physiological action of active constituent included in the secretion of mucous gland, especially potential active constituent, such as may be used
To serve as the hyaluronidase and Eglings of diffusant and antibacterial agent, the water of facial microcirculation, face scar hyperplasia can be improved
Leech element and collagen, elastin, allantoin, chondroitin, antibacterial peptide and other micromolecule polypeptides, in daily skin care item
In application aspect research it is also seldom, at present on the market also without relevant product.
Summary of the invention
The first purpose of this invention is to provide a kind of Regeneration and Repair facial mask liquid using leech mucus extract, can
The sensitive skin inflammatory symptom such as general red, itch, shouting pain, redness, prevention and improvement scar are helped improve, it is mild effectively to inhibit the youth
Acne, acne, obscure appearance accelerate cytothesis, promote healing, repair impaired skin, and light aging, delaying skin is prevented to decline
Always.
The first purpose of this invention is achieved through the following technical solutions:
A kind of Regeneration and Repair facial mask liquid using leech mucus extract, the raw material including following weight percent: A group
Point: glycerol 3~5%, reed fragrant plant oil 0.5~1.0%, EDETATE SODIUM 0.02~0.06%, esters of acrylic acid and carbon 10-30 alkanol third
The mixture 3~7% of olefin(e) acid ester cross-linked polymer, deionized water 85~90%；
The reed fragrant plant oil is glycerol/glyceryl acrylate/acrylic copolymer/propylene glycol/Gantrez AN-119 mixing
Object is the moisturizing substrate of a kind of not dry lubricant and transparent multifunctionality.
B component: deionized water 0.5~1.0%, triethanolamine 0.1~0.5%；
Component C: leech mucus extract 2~10%, butanediol 1~3%；
D component: purslane extract 0.1~1%, Japanese elm root extract 0.1~1%, Phenoxyethanol/pungent glycol 0.1~
0.5%, essence 0.01~0.06%, star anise oil 0.10~1.0%.
Secreting mucus is a kind of common physiological phenomenon of animal.Many aquatic and terrestrial animal can secrete mucus, common
Have earthworm, loach, frog and snail etc..Animal mucus is a kind of than denser colloid, is usually attached to animal body surface,
Not only the effect of lubricating and is wet can be acted, but also can be played an important role in the defence and existence of animal.Leech skin differentiation goes out
All kinds of unicellular bodies of gland wherein there is two class mucous glands can secret out of a large amount of mucus and be covered on body surface, in its natural state may be used
Continuous secretion mucus can largely be secreted in physically different or while being stimulated.It is stayed when leech creeps on the wall of cave when leech hibernation
Under a large amount of mucus, it is ensured that cave is smooth, not dehydration, and the entire winter of cave one all will not be mouldy, finds according to another observation
Hiruto can creep tens meters without scratching oneself in coarse, dry, high temperature petrifying water muddy ground by secretion mucus
Skin, will not be dehydrated and dead, and the worker's hand skin for being in addition responsible for cleaning in hiruto cultivation becomes very soft and smooth,
Being immersed in cold water for a long time will not long pernio.The mucus of leeches secretion can play prevents mechanical damage, keep it is wet and
Antibacterial and sterilization effect, and the invasion of pathogenic microorganism can be resisted.In recent years, biological characteristics, reason in relation to animal mucus
Research in terms of change property and the mechanism of action receives more and more attention, and animal mucus is in cultivation, food, medical treatment, bionical, material
The potentiality to be exploited and application value in the fields such as material, beauty are also paid more and more attention.Leech mucus is a great exploitation potential
Cosmetic material source can provide high-quality natural function ingredient needed for skin care item.
Star anise oil is widely used fragrance.Its application in skin care item is also very extensive, Chinese anise essence
Oil has inhibition to the activity of catalase, can avoid skin allergy；There is facilitation to the generation of collagen, can prevent from wrinkling
The generation of line；There is facilitation to luciferase activation, there is anti-inflammatory.
Japanese elm root extract have the performance of keeping humidity almost the same with hyaluronic acid, while can prevent skin cell by
Extraneous damage, makes skin moisten compact.Purslane extract has the antibiotic property of wide spectrum, and has antiinflammation, can prevent and treat skin
The skin diseases such as skin eczema, allergic dermatitis, contact dermatitis also have good oxygen radical removing ability, have apparent
Antioxidation and good skin moisture-keeping.Japanese elm root extract and purslane extract are all natural extraction product, peace
It is complete effectively, synergistic effect can be played with leech mucus extract.
Second object of the present invention is to provide the system of the above-mentioned Regeneration and Repair facial mask liquid using leech mucus extract
Preparation Method.
Second object of the present invention is achieved through the following technical solutions:
A kind of preparation method of the Regeneration and Repair facial mask liquid using leech mucus extract, comprising the following steps:
(1) component A is heated to being completely dissolved by formula ratio；
(2) component A is added after each raw material mixing of B component is added, is neutralized to transparent；
(3) cool down, temperature is evenly stirred until semi-transparent lotion to the component C mixed is added after 30 DEG C~50 DEG C；
(4) D component, after mixing evenly deaeration, discharging are put into.
Further, the leech mucus extract the preparation method comprises the following steps:
1) it induces the secretion of mucus: taking the healthy leech to stop eating more than 6 months, 1~5 times of pure water of its quality is added, drop
Temperature separates leech and mucus up to mucus to 10 DEG C of 1~5h of holding；
2) extract: the water of 1~5 times of its quality is added in water intaking leech mucus, carries out homogenate in 5~50 DEG C of temperature and extracts 1~3
It is secondary；
3) be centrifuged: 2) the resulting homogenate material of step separated with low speed centrifuge, centrifuge speed for 1000~
5000r/min collects clear liquid；
4) micro-filtration, ultrafiltration, nanofiltration are concentrated, and collect concentrate.
Further, cool down in the step 1) according to the amplitude of 1~5 DEG C/h, the method for the secretion of the induction mucus
It is by the way of gradually cooling down, induction leech largely secretes mucus under low-temperature condition.
Further, the microfiltration step is that the filter membrane for being 0.1~0.5 μm with aperture carries out micro-filtration.
Further, the ultrafiltration step, which is used, is carried out with molecular cut off for the ultrafiltration membrane greater than 6000 dalton.
Further, the leech is hiruto or Hirudo japonica.
Further, the temperature of heating described in step (1) is 75~85 DEG C.
Further, the time of deaeration is 10~30min in the step (4).
Compared with prior art, the device have the advantages that are as follows:
1. facial mask liquid of the invention has the natural antimicrobial component such as leech mucus extract, can help improve it is general it is red,
The inflammatory symptoms such as itch, shouting pain, redness mildly can effectively inhibit whelk, acne, acne, obscure appearance, and can promoting blood circulationization
The stasis of blood promotes healing, prevention and improvement scar.
2. the ingredients such as collagen rich in, elastin, micromolecule polypeptide, can be flesh in leech mucus of the present invention
Skin regeneration provides sufficient nutrition, and leech hyaluronidase can function as diffusant, and skin is helped preferably to absorb nutrition.
3. the leech mucus in facial mask liquid of the invention has high moisturizing ingredient, there are brilliant moisture-keeping functions, and can add
Fast cytothesis repairs impaired skin, prevents light aging, the aging of delaying skin.
4. preparation process of the invention is simple, mucus is secreted using cooling stimulation leech in leech mucus extract, is adopted
It is concentrated with physical method for separation, safe and efficient, molecule is thin, can quickly be absorbed by skin, without side-effects.
Specific embodiment
With reference to embodiment, technical solution of the present invention is described in further detail, but do not constituted pair
Any restrictions of the invention.
Embodiment 1
Regeneration and Repair facial mask liquid each component content is as shown in the table:
Using the Regeneration and Repair facial mask formula of liquid of leech mucus extract
Using the preparation method of the Regeneration and Repair facial mask liquid of leech mucus extract:
(1) it induces the secretion of mucus: taking the healthy leech to stop eating in right amount more than 6 months, 2 times of pure water of its quality are added,
10 DEG C are reduced to from room temperature according to the amplitude of 1 DEG C/h, 2h is kept, leech and mucus is separated, mucus is obtained；
(2) extract: the water of 2 times of its quality is added in water intaking leech mucus, carries out homogenate in 5 DEG C of temperature and extracts 2 times；
(3) it is centrifuged: the resulting homogenate material of (2) step being separated with low speed centrifuge, centrifuge speed 5000r/
Min collects clear liquid；
(4) micro-filtration: clear liquid carries out micro-filtration with the filter membrane that aperture is 0.45 μm；
(5) ultrafiltration: ultrafiltration is carried out with the ultrafiltration membrane that molecular cut off is 30000 dalton；
(6) determining the protein quantity: concentrate need to measure the content of concentrate albumen with Coomassie Brilliant Blue, and measuring concentration is
200mg/L；
(7) nanofiltration: being concentrated with the nanofiltration membrane of 1000 dalton of molecular cut off, collects concentrate, and be diluted to
500mg/L；
(8) component A is weighed in investment pot one by one, is heated to 80 DEG C and is completely dissolved；
(9) B component first use a pannikin mix, then be added component A in mix slowly be neutralized to it is transparent；
(10) cool down, temperature is evenly stirred until semi-transparent lotion to the component C being added after 40 DEG C after mixing；
(11) D component is put into, is stirred evenly, is vacuumized and mix slowly deaeration 20min, is discharged；
(12) inspection by sampling, after the inspection of semifinished product is qualified, feed liquid is dispensed according to regulation product specification.
Embodiment 2
Difference from Example 1 is that star anise oil 1.00%, leech mucus extract is 10.00%, A
Deionized water is 73.92% in component.
(1) it induces the secretion of mucus: taking the healthy leech to stop eating in right amount more than 6 months, 3 times of pure water of its quality are added,
10 DEG C are reduced to from room temperature according to the amplitude of 3 DEG C/h, 2h is kept, leech and mucus is separated, mucus is obtained.
(4) micro-filtration: clear liquid carries out micro-filtration with the filter membrane that aperture is 0.13 μm.
(5) ultrafiltration: ultrafiltration is carried out with the ultrafiltration membrane that molecular cut off is 10000 dalton.
(6) determining the protein quantity: concentrate need to measure the content of concentrate albumen with Coomassie Brilliant Blue, and measuring concentration is
100mg/L；
Embodiment 3
It is with 1 difference of embodiment, star anise oil 0.20%, leech mucus extract is 2.00%, in component A
Deionized water is 82.72%.
(1) it induces the secretion of mucus: taking the healthy leech to stop eating in right amount more than 6 months, 5 times of pure water of its quality are added,
10 DEG C are reduced to from room temperature according to the amplitude of 3 DEG C/h, 2h is kept, leech and mucus is separated, mucus is obtained.
(4) micro-filtration: clear liquid carries out micro-filtration with the filter membrane that aperture is 0.13 μm.
(5) ultrafiltration: ultrafiltration is carried out with the ultrafiltration membrane that molecular cut off is 50000 dalton.
(6) determining the protein quantity: concentrate need to measure the content of concentrate albumen with Coomassie Brilliant Blue, and measuring concentration is
60mg/L；
Invention carefully takes out mask sheet together in 10~15min on the face, is applied when using, for facial mask without cleaning, facial mask is every
Week uses 4 times.
The assessment of Regeneration and Repair facial mask liquid using effect of the present invention using leech mucus extract is tested:
Research object: acne, scar, inflammation skin, obscure, color spot, wrinkle skin and general red, sensitive, dry flesh are selected
3 kinds of skin triers including skin, every kind of problem skin choose 80 people, are divided into 4 groups, each 20 people of group, group 1 is in fact
Apply the facial mask of example 1, the facial mask of the embodiment 2 of group 2, the facial mask of the embodiment 3 of group 3, group 4 mentions with leech mucus is not added with
The control group facial mask facial mask of object, purslane extract, Japanese elm root extract and star anise oil is taken, weekly using 4 times, continuously
Using 1 month, trier's skin is recorded, is specifically shown in Table 1.
1 leech mucus extract Regeneration and Repair facial mask using effect of table
As can be seen from Table 1, the present invention is to acne, scar, inflammation skin, obscure, color spot, wrinkle skin and general red, quick
Sense, a variety of skin problems including dry skin have a significant curative effect, and its to the curative effect of various skin quality with the water in formula
The increase of leech mucus extract and increase, while be formulated in star anise oil synergistic effect can be generated with it, the present invention is ground
The applicable skin quality range of the facial mask of system is wide, has multiple curative effect, adheres to being used for a long time, effect is more significant.
The foregoing is merely section Examples of the invention, are not intended to restrict the invention: for those skilled in the art
For member, the invention may be variously modified and varied.All within the spirits and principles of the present invention, it is made it is any modification,
Equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of Regeneration and Repair facial mask liquid using leech mucus extract, which is characterized in that including following weight percent
Raw material:
Component A: glycerol 3~5%, reed fragrant plant oil 0.5~1.0%, EDETATE SODIUM 0.02~0.06%, esters of acrylic acid and carbon 10-
The mixture 3~7% of 30 alkylol acrylamide acid esters cross-linked polymers, deionized water 85~90%；
B component: deionized water 0.5~1.0%, triethanolamine 0.1~0.5%；
Component C: leech mucus extract 2~10%, butanediol 1~3%；
D component: purslane extract 0.1~1%, Japanese elm root extract 0.1~1%, Phenoxyethanol/pungent glycol 0.1~
0.5%, essence 0.01~0.06%, star anise oil 0.10~1.0%.
2. a kind of preparation method of the Regeneration and Repair facial mask liquid described in claim 1 using leech mucus extract, feature
It is, comprising the following steps:
(1) component A is heated to being completely dissolved by formula ratio；
(2) component A is added after each raw material mixing of B component is added, is neutralized to transparent；
(3) cool down, temperature is evenly stirred until semi-transparent lotion to the component C mixed is added after 30 DEG C~50 DEG C；
(4) D component, after mixing evenly deaeration, discharging are put into.
3. the preparation method of the Regeneration and Repair facial mask liquid according to claim 2 using leech mucus extract, feature
Be, the leech mucus extract the preparation method comprises the following steps:
1) it induces the secretion of mucus: taking the healthy leech to stop eating more than 6 months, 1~5 times of pure water of its quality is added, is cooled to
10 DEG C of 1~5h of holding separate leech and mucus up to mucus；
2) extract: the water of 1~5 times of its quality is added in water intaking leech mucus, carries out homogenate in 5~50 DEG C of temperature and extracts 1~3 time；
3) it is centrifuged: 2) the resulting homogenate material of step is separated with low speed centrifuge, centrifuge speed is 1000~5000r/
Min collects clear liquid；
4) micro-filtration, ultrafiltration, nanofiltration are concentrated, and collect concentrate.
4. the preparation method of the Regeneration and Repair facial mask liquid according to claim 3 using leech mucus extract, feature
It is, cools down in the step 1) according to the amplitude of 1~5 DEG C/h.
5. the preparation method of the Regeneration and Repair facial mask liquid according to claim 3 or 4 using leech mucus extract, special
Sign is that the microfiltration step is that the filter membrane for being 0.1~0.5 μm with aperture carries out micro-filtration.
6. the preparation method of the Regeneration and Repair facial mask liquid according to claim 5 using leech mucus extract, feature
It is, the ultrafiltration step, which is used, to be carried out with molecular cut off for the ultrafiltration membrane greater than 6000 dalton.
7. the preparation method of the Regeneration and Repair facial mask liquid according to claim 2 using leech mucus extract, feature
It is, the temperature of heating described in step (1) is 75~85 DEG C.
8. the preparation method of the Regeneration and Repair facial mask liquid according to claim 2 using leech mucus extract, feature
It is, the time of deaeration is 10~30min in the step (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910768015.5A CN110302133A (en) | 2019-08-20 | 2019-08-20 | A kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910768015.5A CN110302133A (en) | 2019-08-20 | 2019-08-20 | A kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110302133A true CN110302133A (en) | 2019-10-08 |
Family
ID=68083645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910768015.5A Withdrawn CN110302133A (en) | 2019-08-20 | 2019-08-20 | A kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110302133A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917218A (en) * | 2019-12-06 | 2020-03-27 | 云南慎言生物科技有限公司 | Application of leech body surface secretion in preparation of scar repairing medicine |
| WO2022100807A1 (en) * | 2020-11-11 | 2022-05-19 | Bioresources Technology & Engineering Gmbh (Bite) | Mucus from leeches and use in cosmetic preparations |
-
2019
- 2019-08-20 CN CN201910768015.5A patent/CN110302133A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917218A (en) * | 2019-12-06 | 2020-03-27 | 云南慎言生物科技有限公司 | Application of leech body surface secretion in preparation of scar repairing medicine |
| WO2022100807A1 (en) * | 2020-11-11 | 2022-05-19 | Bioresources Technology & Engineering Gmbh (Bite) | Mucus from leeches and use in cosmetic preparations |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10869948B2 (en) | Composition of collagen peptide and elastin peptide, method of producing the same and use thereof | |
| CN110123729A (en) | A kind of jelly film and preparation method thereof | |
| CN113332162B (en) | protamine-PDRN compound, composition and application in preparation of skin care product | |
| CN108670901B (en) | Skin softening lotion with macadamia nut protein peptide and green tangerine peel extract as active ingredients and preparation method thereof | |
| CN113693979B (en) | Oil-control acne-removing composition and application thereof | |
| WO2024045952A1 (en) | Recombinant collagen-containing composition having effects of repairing and soothing, eye cream containing same, preparation method therefor, and use thereof | |
| CN110302133A (en) | A kind of Regeneration and Repair facial mask liquid and preparation method thereof using leech mucus extract | |
| CN109260116A (en) | It is a kind of containing plant extracts to peptide skin base solution and its production technology | |
| CN111317680A (en) | Facial essence and preparation method thereof | |
| CN112891286A (en) | Beautifying and firming repair cream and preparation method thereof | |
| CN113332160A (en) | Cosmetic composition for conditioning peritrichotic skin | |
| CN108261361A (en) | A kind of anti-acne repairing paste containing Porcine HGF and preparation method thereof | |
| CN104546591A (en) | Plant essential oil facial mask and preparation method thereof | |
| KR20170004626A (en) | A cosmetic composition using silkworm-derived extracts | |
| CN117064821A (en) | Oil control and/or acne removal composition, and preparation and application thereof | |
| CN115429738B (en) | Acne-removing, repairing and reviving essence and preparation method thereof | |
| AU2014253131A1 (en) | Synergistic combination of alanine-glutamine, hyaluronic acid and an oat extract and the use thereof in a composition intended for healing wounds and repairing skin lesions | |
| CN110368331A (en) | A kind of anti-inflammatory anti-acne of the essential oil containing Baeckea frutescens L. repairs facial mask liquid and preparation method thereof | |
| CN110652486A (en) | Medicinal acne-removing gel | |
| WO2022167202A1 (en) | Bertholletia excelsa extract and use thereof | |
| CN111773128A (en) | Anti-allergy mask repairing liquid and preparation method thereof | |
| CN111728916A (en) | Soothing and multiple moisturizing cream | |
| KR20110063912A (en) | A topical composition comprising the extract of platycodi radix, bupleuri radix and ginseng radix and the purified fractions therefrom inhibiting skin aging and wrinkle formation | |
| CN111481476A (en) | Potato facial mask with multiple skin care effects and preparation method thereof | |
| KR100861415B1 (en) | Method of preparing cosmetics composition and cosmetics for anti-oxidation and skin-calming, prepared therefrom |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20191008 |
|
| WW01 | Invention patent application withdrawn after publication |