CN110652486A

CN110652486A - Medicinal acne-removing gel

Info

Publication number: CN110652486A
Application number: CN201911099521.6A
Authority: CN
Inventors: 马恩先
Original assignee: Jiangsu Yijie Biotechnology Co Ltd
Current assignee: Jiangsu Yijie Biotechnology Co Ltd
Priority date: 2019-11-12
Filing date: 2019-11-12
Publication date: 2020-01-07

Abstract

The invention discloses a medicinal acne-removing gel in the technical field of cosmetics, which contains methyl propylene glycol, butanediol salvia miltiorrhiza root extract, clove bud extract, scutellaria root extract, angelica root extract, licorice root extract, centella asiatica extract, glycerin, PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil, wild soybean seed extract, hexanediol, caprylyl hydroximic acid, tetrahydroxypropyl ethylenediamine, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, sodium polyacrylate, melaleuca alternifolia oil, xanthan gum EDTA disodium and the balance of water. The acne-removing cream has the effects of skin purification and acne-removing repair aiming at people with sensitive skin, and is quick in acne-removing effect and good in acne-removing effect.

Description

Medicinal acne-removing gel

Technical Field

The invention relates to a cosmetic, in particular to an acne-removing gel.

Background

Pox, also known as "acne", is a chronic inflammatory follicular sebaceous gland disease that occurs in adolescent populations and is therefore called "whelk" by chance. Its onset is mainly related to the level of sex hormones and the abundance of sebum

Secretion, proliferation of propionibacterium acnes, dyskeratosis of the pilosebaceous ducts.

Whelks are frequently found in areas rich in sebaceous glands. Acne, blackheads, papules, pustules, nodules and scars appear on the face, the front chest and the back. Adult pox: also called as post-whelk, is mostly related to environmental stimulation, bad living habits, stress and the like, and is most easily bred by urban people with mixed skin of 25 to 35 years old.

In the Chinese patent database, an anti-acne gel added with pearl hydrolysate liposome is disclosed, and the publication number is as follows: CN101697956A, application date: 20091019, respectively; the publication date is as follows: 20100428, respectively; the acne-removing gel is prepared by uniformly mixing acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, glycerol, 1, 3-butanediol, witch hazel extract, pearl hydrolysate liposome, phytosterol, caprylyl glycine, allantoin, dipotassium glycyrrhizinate, diazolidinyl urea, methylparaben, triethanolamine, disodium ethylene diamine tetraacetate and deionized water, wherein the contents of the components in percentage by weight are respectively as follows: 0.3-0.8% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 2.0-5.0% of glycerol, 2.0-5.0% of 1, 3-butanediol, 2.0-5.0% of witch hazel extract, 3.0-8.0% of pearl hydrolysate liposome, 1.0-5.0% of phytosterol, 0.2-1.0% of caprylyl glycine, 0.1-0.2% of allantoin, 0.1-0.4% of dipotassium glycyrrhizinate, 0.1-0.5% of diazolidinyl urea, 0.1-0.2% of methyl hydroxybenzoate, 0.5-1.0% of triethanolamine, 0.05-0.15% of disodium ethylene diamine tetraacetate, and the balance of ionized water. When in preparation, the process steps are as follows:

1) soaking acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer in deionized water for 0.5-1.5 hours, adding glycerol, 1, 3-butanediol, witch hazel extract, allantoin, methylparaben and disodium ethylene diamine tetraacetate, mixing, putting into an emulsifying pot, stirring and heating to 80-85 ℃; keeping the vacuum degree and continuously degassing until the glass is transparent and has no bubbles;

2) adding triethanolamine and stirring uniformly at the temperature of 80-85 ℃;

3) cooling to 40-50 ℃, adding the pearl hydrolysate liposome, phytosterol, caprylyl glycine and diazolidinyl urea, uniformly stirring and discharging to obtain a finished product.

In the Chinese patent database, a mung bean enzyme face-cleaning gel is also disclosed, and the application date is as follows: 20160526, respectively; publication No.: CN 105832649A; the publication date is as follows: 20160810, respectively; the face-cleaning jelly comprises the following components in percentage by weight: 0.8-1.2 parts of alkanol acrylate cross-linked polymer, 20-30 parts of lactobacillus or mung bean seed extract fermentation product filtrate, 0.05-0.1 part of EDTA disodium, 0.3-0.5 part of aloe barbadensis leaf extract, 1-3 parts of trehalose, 30% sodium lauroyl sarcosinate 2-6 parts of jojoba wax PEG-120 esters 1-3 parts of butanediol 1-5 parts of butanediol, 0.01-0.05 part of usnea barbata extract, 0.1-0.3 part of chlorphenesin, 0.5-2 parts of podocarpus macrophyllus extract, 0.8-1.5 parts of 1.3 propylene glycol, 1-4 parts of PEG-40 hydrogenated castor oil, 1-4 parts of olive oil PEG-7 esters, 1-5 parts of coco glucoside, 2-4 parts of water, 2-5 parts of chitosan mono-succinamide, and 10% of potassium hydroxide for adjusting the pH value to 5-6, The 5% repairing traditional Chinese medicine extract and the balance repairing traditional Chinese medicine extract comprise the following components in parts by weight: 200 parts of licorice root, 200 parts of purslane, 100 parts of sophora flavescens, 100 parts of scutellaria baicalensis root, 100 parts of polygonatum, 100 parts of common andrographis herb, 100 parts of rehmannia, 100 parts of rhizoma anemarrhenae and 100 parts of peony.

The face-cleaning gel in the prior art has certain acne-removing and face-cleaning effects, but also has the problems of low acne-removing speed and unobvious effect.

Disclosure of Invention

The invention aims to provide the medicinal acne-removing gel which has quick response and good acne-removing effect.

The purpose of the invention is realized as follows: the medicinal acne-removing gel comprises the following components in parts by mass:

methyl propylene glycol 5.5 ~ 6.5.5%

Butanediol 4.5 ~ 5.5.5%

Radix Salviae Miltiorrhizae extract 0.45 ~ 0.5.5%

Flos Caryophylli bud extract 0.15 ~ 0.2.2%

Radix Scutellariae extract 0.1 ~ 0.15.15%

Radix Angelicae sinensis extract 0.1 ~ 0.15.15%

Glycyrrhrizae radix extract 0.04 ~ 0.08.08%

Centella asiatica extract 0.04 ~ 0.08.08%

Glycerol 3.5 ~ 4%

PPG-26-Butaneth-260.5 ~ 0.6.6%

PEG-40 hydrogenated Castor oil 0.32 ~ 0.38.38%

Semen GLYCINEs (Glycine SOJA) seed extract 0.22 ~ 0.28.28%

Hexanediol 0.25 ~ 0.32.32%

0.25 ~ 0.32.32% of octanoyl hydroximic acid

Tetrahydroxypropyl ethylenediamine 0.4 ~ 0.5.5%

acrylic/C10-30 Alkanolacrylate crosspolymer 0.25 ~ 0.35.35%

Sodium polyacrylate 0.18 ~ 0.25.25%

0.18% of melaleuca alternifolia leaf oil, 0.18 ~ 0.22% of melaleuca alternifolia leaf oil

Xanthan gum 0.08 ~ 0.12.12%

EDTA disodium 0.04 ~ 0.06.06%

The balance being water.

The invention has the preferable scheme that the composition comprises the following components by mass: methyl propylene glycol 6%, butanediol 4.98%, salvia miltiorrhiza root extract 0.48%, clove bud extract 0.18%, scutellaria baicalensis root extract 0.12%, angelica root extract 0.12%, licorice root extract 0.06%, centella asiatica extract 0.06%, glycerin 3.75%, PPG-26-butanol polyether-260.55%, PEG-40 hydrogenated castor oil 0.35%, wild soybean (Glycine SOJA) seed extract 0.25%, hexanediol 0.3%, caprylyl hydroximic acid 0.3%, tetrahydroxypropyl ethylenediamine 0.45%, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.3%, sodium polyacrylate 0.2%, melaleuca alternifolia leaf oil 0.2%, xanthan gum 0.1%, disodium EDTA 0.05%, and the balance of water.

In the invention, the main functions of the components are as follows: methyl propylene glycol, moisturizing lubricant (slightly refreshing); butanediol: moisturizing lubricants (partial moisturizing); the salvia miltiorrhiza root extract has the functions of bacteriostasis, oil control and inflammation diminishing; clove bud extract: pores are dredged and absorption is promoted; the scutellaria root extract has the functions of clearing heat, purging fire and removing toxin, and can kill pox virus by internal heat; the angelica root extract has the functions of promoting blood circulation to remove blood stasis and improving the keratosis of hair follicles; the licorice root extract and the centella asiatica extract have the effects of harmonizing and repairing; glycerol: moisturizing effect (partial harmony); PPG-26-Butaneth-26: the solubilizer is used for fusing various effective substances in the system; PEG-40 hydrogenated castor oil: the solubilizer is used for fusing various effective substances in the system; extract of soybean seeds: moistening the skin; hexanediol: oxidation resistance and long shelf life; caprylyl hydroximic acid: oxidation resistance and long shelf life; tetrahydroxypropyl ethylenediamine: PH neutralizer, which is controlled to be weak acidic between pH 5.5-6.5; acrylic/C10-30 alkanol acrylate crosspolymer: a thickener; sodium polyacrylate: a lubricant; melaleuca alternifolia leaf oil, also known as tea tree oil: sterilization and inflammation diminishing; xanthan gum: a thickener; disodium EDTA: decocting the mixture, and decocting calcium and magnesium ions in the formula; water: a solvent.

The formula is gel, multiple traditional Chinese medicines are compounded, and the gel has the effects of single component and mutual synergy, wherein a clove bud extract and a scutellaria root extract are used for promoting the permeation and absorption of a salvia root extract and a angelica root extract to skin pores, so that the inhibition to 5 alpha-reductase and acne bacteria is achieved, the secretion of skin grease is controlled, the skin inflammation is eliminated, the effects of promoting blood circulation and removing blood stasis of the skin are achieved, the keratinization of the skin hair follicle is improved, the liquorice root extract and a centella extract enable the skin not to generate new propionibacterium acnes and staphylococcus aureus while the 5 alpha-reductase and the acne bacteria are inhibited, the skin is further repaired, the tea tree oil and the six plant extracts are added to form a matching effect, the effects of diminishing inflammation, inhibiting bacteria, eliminating the secretion of redundant grease and regulating the balance of skin grease are achieved, is helpful for removing skin bacteria and effectively accelerating the treatment of acne.

The gel formula uses the synergistic effect of three moisturizing emollients (methyl propylene glycol, butanediol and glycerol), can keep moisture for a long time after being applied so as to form a skin fat film on the surface of the skin, is supplemented with the emollients of the wild soybean seed extract and the thickening agent acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and xanthan gum so as to moisturize the skin, and is added with an antioxidant and a decoction agent to prepare gel-shaped gel.

The medicinal anti-acne gel provided by the invention can be used for people with sensitive skin, and has the functions of skin purification and anti-acne repair. Compared with the prior art, the acne removing cream has the advantages of quick acne removing effect and good acne removing effect, and is specifically shown in the following steps:

1. can enhance skin resistance, improve skin, and recover barrier function;

2. inhibiting the growth of comedo, and avoiding pore blockage by purifying cuticle; controlling excessive sebum to prevent sebum oxidation; meanwhile, can adsorb sebum peroxide to prevent acne deterioration;

3. the acne mark can be removed, and acne pigmentation can be eliminated without leaving acne mark.

Drawings

Fig. 1 is a graph showing the effect of inhibiting 5 α -reductase activity in example 1 of the present invention.

Fig. 2 is a graph of the effect of inhibiting acne bacteria.

Fig. 3 is a comparison graph of experimental effects of rabbit ear canal acne.

Fig. 4 is a comparison graph of experimental effects on human faces.

Detailed Description

Example 1

The medicinal acne-removing gel comprises the following components in parts by mass: methyl propylene glycol 6%, butanediol 4.98%, salvia miltiorrhiza root extract 0.48%, clove bud extract 0.18%, scutellaria baicalensis root extract 0.12%, angelica root extract 0.12%, licorice root extract 0.06%, centella asiatica extract 0.06%, glycerin 3.75%, PPG-26-butanol polyether-260.55%, PEG-40 hydrogenated castor oil 0.35%, wild soybean (Glycine SOJA) seed extract 0.25%, hexanediol 0.3%, caprylyl hydroximic acid 0.3%, tetrahydroxypropyl ethylenediamine 0.45%, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.3%, sodium polyacrylate 0.2%, melaleuca alternifolia leaf oil 0.2%, xanthan gum 0.1%, disodium EDTA 0.05%, and the balance of water.

Wherein

Component name	Production plantHome-use	Goods number or specification
			Salvia miltiorrhiza root extract	Vast Shanghai chemical technology Co Ltd	MS-DSG-010
Bud extract of clove	Shanghai Puen Biochemical technology Ltd	PE-LILAC-050
			Scutellaria root extract	Shanghai Puen Biochemical technology Ltd	PE-LILBA-009
Angelica root extract	Vast Shanghai chemical technology Co Ltd	MS-DGG-101
			Licorice root extract	Shanghai Boxue industries Ltd	SH-LICORICE-015
Centella asiatica extract	Shanghai Boxue industries Ltd	SH-CENTELLA-020
			Extract of wild soybean seeds	Shanghai Heng chemical Co Ltd	HL-SOYBEAN-500
Leaf of interbody fernMelaleuca alternifolia oil	Shanghai Heng chemical Co Ltd	HL-MELALEUCA-07

The remaining raw materials are commercially available from the chemical raw material market.

When the raw materials are used for preparing the acne-removing gel, the steps are as follows:

1. adding deionized water into an emulsifying pot, starting stirring (speed is 15 r/min), slowly adding acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum and sodium polyacrylate, and dissolving for 15-20 min to be transparent;

2. heating to 85 ℃, adding EDTA disodium, caprylyl hydroximic acid, hexanediol, butanediol, methyl propanediol and glycerol, and stirring for 30 minutes at the constant temperature until the mixture is transparent;

3. cooling to 60 deg.C, adding semen glycines seed extract, PPG-26 Butanol polyether-26, PEG-40 hydrogenated castor oil and Melaleuca alternifolia leaf oil, cooling to 45 deg.C, adding tetrahydroxypropyl ethylenediamine, and stirring for 20 min to obtain gel-like gel;

4. cooling to 38 deg.C, adding six plant extracts including radix Salviae Miltiorrhizae extract, flos Caryophylli bud extract, radix Scutellariae extract, radix Angelicae sinensis extract, radix Glycyrrhizae extract, and herba Centellae extract, stirring for 30 min, mixing completely, and testing pH to 5.5-6.5.

Fig. 1 is a graph showing the experimental effect of the product of this embodiment on inhibiting 5 α -reductase activity, where finasteride and blank matrix are used as comparison objects, and the product with a mass concentration of 1-5% in the graph has a good effect of inhibiting 5 α -reductase activity, which indicates that it can inhibit the secretion of sebum from hair follicle of human body. The 5 alpha-reductase inhibition rate gradually increases with the increase of the mass concentration.

Fig. 2 is a bacteriostatic effect diagram of the product of this embodiment, in the experiment, propionibacterium acnes, staphylococcus aureus, staphylococcus epidermidis, escherichia coli and pseudomonas aeruginosa are cultured first, and an agar diffusion test is performed after proliferation, that is, the product of this embodiment with a concentration of 5% diffuses from a plastic test strip into agar, and the growth of the tested bacteria is inhibited within a bacteriostatic concentration range around the test strip, so that a transparent bacteriostatic ring is formed.

Fig. 3 shows that the pox-causing sample is adopted to induce a rabbit ear acne model, and the skin reaction of the rabbit ear canal skin after the pox-causing sample is continuously and locally smeared is observed, so that the acne-removing effect can be evaluated. The samples were applied 1 time daily for 2 weeks. After 24 hours of the last smearing, whether the expressions such as pore expansion, hyperkeratosis of hair follicle parts and the like exist or not is judged by visual observation; then, HE staining (Hematoxylin-eosintinating) was performed to the sections, and the change of the tissue was observed by an optical microscope. The results show that: the pox-causing samples resulted in mild dilation of hair follicles in the skin of rabbit ear canals, mild proliferation of keratinocytes and the appearance of small papules (fig. 3 a); from the photographs of the rabbit ear skin sections, the tissue structure was intact, the hair follicles on the epidermis were slightly dilated, the keratinocytes were slightly hyperplastic (fig. 3 b), and the acne infection was successful.

Then, the product is smeared for 3 times a day, the rabbit ears are well sliced after being cleaned regularly before smearing, and after 20 days, the rabbit ears are detected again, which shows that the acne is cured, and the acne is shown in fig. 3c and d.

Fig. 4 is a comparison graph of experimental effects on human faces, and the forehead acne of a male subject 25 years old and tested is obvious, and the forehead acne is obviously reduced after 7 days, 14 days and 21 days of the acne-removing gel provided by the invention.

Example 2

The medicinal acne-removing gel comprises the following components in parts by mass:

5.5 percent of methyl propylene glycol

Butanediol 5.5%

Radix Salviae Miltiorrhizae extract 0.45%

Flos Caryophylli bud extract 0.2%

0.1% of scutellaria root extract

Radix Angelicae sinensis extract 0.15%

Glycyrrhrizae radix extract 0.04%

Centella asiatica extract 0.08%

3.5 percent of glycerin

PPG-26-Butanethol-260.6%

PEG-40 hydrogenated Castor oil 0.32%

Semen glycines extract 0.28%

0.25 percent of hexanediol

0.32 percent of octanoyl hydroximic acid

0.4 percent of tetrahydroxypropyl ethylenediamine

Acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.35%

0.18 percent of sodium polyacrylate

0.22 percent of melaleuca alternifolia leaf oil

Xanthan gum 0.08%

EDTA disodium 0.06%

The balance being water.

Example 3

6.5 percent of methyl propylene glycol

4.5 percent of butanediol

Radix Salviae Miltiorrhizae extract 0.5%

Flos Caryophylli bud extract 0.15%

Radix Scutellariae extract 0.15%

0.1% of Angelica root extract

Glycyrrhrizae radix extract 0.08%

Centella asiatica extract 0.04%

4 percent of glycerin

PPG-26-Butanethol-260.5%

PEG-40 hydrogenated Castor oil 0.38%

Semen glycines extract 0.22%

0.32 percent of hexanediol

0.25 percent of octanoyl hydroximic acid

0.5 percent of tetrahydroxypropyl ethylenediamine

Acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.25%

0.25 percent of sodium polyacrylate

0.18 percent of melaleuca alternifolia leaf oil

Xanthan gum 0.12%

EDTA disodium 0.04%

The balance being water.

Example 4

6 percent of methyl propylene glycol

Butanediol 5%

Radix Salviae Miltiorrhizae extract 0.5%

Flos Caryophylli bud extract 0.15%

0.1% of scutellaria root extract

0.1% of Angelica root extract

Glycyrrhrizae radix extract 0.06%

Centella asiatica extract 0.06%

4 percent of glycerin

PPG-26-Butanethol-260.5%

PEG-40 hydrogenated Castor oil 0.35%

Semen glycines extract 0.25%

0.3 percent of hexanediol

0.25 percent of octanoyl hydroximic acid

0.45 percent of tetrahydroxypropyl ethylenediamine

Acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.3%

0.2 percent of sodium polyacrylate

0.2 percent of melaleuca alternifolia leaf oil

Xanthan gum 0.1%

EDTA disodium 0.06%

The balance being water.

Tests prove that the acne removing effect is good when the acne removing agent is tested by the examples 2 to 4 for acne people.

The present invention is not limited to the above-mentioned embodiments, and based on the technical solutions disclosed in the present invention, those skilled in the art can make some substitutions and modifications to some technical features without creative efforts according to the disclosed technical contents, and these substitutions and modifications are all within the protection scope of the present invention.

Claims

1. The medicinal acne-removing gel is characterized by comprising the following components in percentage by mass:

methyl propylene glycol 5.5 ~ 6.5.5%

Butanediol 4.5 ~ 5.5.5%

Radix Salviae Miltiorrhizae extract 0.45 ~ 0.5.5%

Flos Caryophylli bud extract 0.15 ~ 0.2.2%

Radix Scutellariae extract 0.1 ~ 0.15.15%

Radix Angelicae sinensis extract 0.1 ~ 0.15.15%

Glycyrrhrizae radix extract 0.04 ~ 0.08.08%

Centella asiatica extract 0.04 ~ 0.08.08%

Glycerol 3.5 ~ 4%

PPG-26-Butaneth-260.5 ~ 0.6.6%

PEG-40 hydrogenated Castor oil 0.32 ~ 0.38.38%

Semen glycines extract 0.22 ~ 0.28.28%

Hexanediol 0.25 ~ 0.32.32%

0.25 ~ 0.32.32% of octanoyl hydroximic acid

Tetrahydroxypropyl ethylenediamine 0.4 ~ 0.5.5%

acrylic/C10-30 Alkanolacrylate crosspolymer 0.25 ~ 0.35.35%

Sodium polyacrylate 0.18 ~ 0.25.25%

Xanthan gum 0.08 ~ 0.12.12%

EDTA disodium 0.04 ~ 0.06.06%

The balance being water.

2. The medicinal acne-removing gel according to claim 1, which is characterized by comprising the following components in percentage by mass: methyl propylene glycol 6%, butylene glycol 4.98%, salvia miltiorrhiza root extract 0.48%, clove bud extract 0.18%, scutellaria baicalensis root extract 0.12%, angelica root extract 0.12%, licorice root extract 0.06%, centella asiatica extract 0.06%, glycerin 3.75%, PPG-26-butanol polyether-260.55%, PEG-40 hydrogenated castor oil 0.35%, glycine soja seed extract 0.25%, hexylene glycol 0.3%, caprylyl hydroximic acid 0.3%, tetrahydroxypropyl ethylenediamine 0.45%, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.3%, sodium polyacrylate 0.2%, melaleuca alternifolia leaf oil 0.2%, xanthan gum 0.1%, disodium EDTA 0.05%, and the balance of water.