CN110859780A - Non-invasive wrinkle-removing anti-aging beauty method - Google Patents
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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Abstract
The invention provides a non-invasive wrinkle-removing and anti-aging beauty method, which comprises the following steps: (1) coating the skin with 1% azone aqueous solution by weight, and after 10-15 seconds, washing with clear water and wiping the skin dry; (2) preparation using nano gold baseCoating on skin, drying, and irradiating with 980nm near infrared light with laser intensity of 0.35-0.40W/cm2The skin care method can remarkably improve the elasticity, wrinkle resistance and anti-aging performance of the skin, and can provide long-acting protection for the skin.
Description
Technical Field
The invention belongs to the technical field of beauty treatment, and particularly relates to a non-invasive wrinkle-removing and anti-aging beauty treatment method.
Background
In modern life, more and more people have skin problems due to the accelerated pace of life and the increasingly frequent social activities. Wrinkles are one of the skin problems that cannot be neglected.
In the prior art, related researches on skin wrinkle resistance have been carried out by some technologies, such as chinese patents CN102863552A, CN107375142A, etc. However, in the present research, anti-wrinkle compositions are mainly studied, and there is little concern about how to enhance the further efficacy of certain anti-wrinkle ingredients.
Disclosure of Invention
In view of the shortcomings of the prior art and the market needs, the present invention aims to provide a method capable of enhancing β -1,3 glucan and polypeptide in anti-wrinkle and anti-aging aspects of skin.
A non-invasive wrinkle-removing anti-aging cosmetic method, comprising the steps of:
(1) coating the skin with 1% azone aqueous solution by weight, and after 10-15 seconds, washing with clear water and wiping the skin dry;
(2) coating the skin with the nanogold-based preparation, and after drying, irradiating the skin with near infrared light with the wavelength of 980nm, wherein the laser intensity is 0.35-0.40W/cm2The irradiation time is 15-20 seconds;
(3) applying a beauty dressing, wherein the beauty dressing comprises β -1,3 glucan and polypeptide, and the weight ratio of β -1,3 glucan to polypeptide is 1: 2-10;
the polypeptide is any one of acetyl hexapeptide-8, acetyl hexapeptide-3, tetrapeptide 21, carnosine, aminobutyric acid, conopeptide, palmitoyl pentapeptide-4, palmitoyl pentapeptide-5, tripeptide-1 copper and snake venom like peptide.
In the nano gold-based preparation, a nano gold base consists of nano gold and nano copper sulfide, and the weight ratio of the nano gold to the nano copper sulfide is 6: 1; the preparation type of the nano-gold-based preparation is nano-particle solution or gel.
Acetyl hexapeptide-8 is a known and widely used wrinkle-removing cosmetic raw material, is called as achirelin, can locally block nerve transmission muscle contraction information, influences leather sac nerve conduction, enables facial muscles to relax, and achieves the effect of smoothing wrinkles.
In other studies conducted in the same period as the study, the anti-wrinkle effect of acetyl hexapeptide-8 can be remarkably enhanced β -1,3 glucan by laser irradiation after the skin is coated with the nanogold-based preparation, however, when the operation is performed after the acetyl hexapeptide-8 is added into a cosmetic dressing, the operation is not enhanced in the anti-wrinkle effect of acetyl hexapeptide-8.
On the basis, the invention discovers that the azone has the anti-wrinkle effect and the enhancement effect of the substances after the acetyl hexapeptide-8 is replaced by the acetyl hexapeptide-3, the tetrapeptide 21, the carnosine, the aminobutyric acid, the conopeptide, the palmitoyl pentapeptide-4, the palmitoyl pentapeptide-5, the tripeptide-1 copper and the snake venom-like peptide.
Through the study of the invention, the following preliminary conclusions can be obtained:
the polypeptide of the present invention usually needs to reach the dermis layer of the skin to exert a better anti-wrinkle effect. In the prior art, only a small amount of polypeptide can penetrate through the skin to reach the dermis layer by means of smearing; the skin is damaged by the introduction mode of injection in the market, the efficacy of anti-wrinkle components is affected, and pain and postoperative recovery are caused in the treatment process. The introduction mode of the invention has the advantages of no wound, no pain and no recovery period, can promote the absorption of polypeptide, enhance the skin barrier and synergistically achieve better anti-wrinkle effect.
In a preferred embodiment of the invention, the particle size of the nano gold and the particle size of the nano copper sulfide are both 120-200 nm. It should be noted that the particle size referred to herein does not refer to a specific particle size value or an average particle size value, but refers to the particle size range of the obtained nano gold or nano copper sulfide product being 120 to 200nm, i.e., the obtained product is composed of particles with different particle sizes in this particle size range.
In a preferred embodiment of the present invention, the laser intensity is 0.40W/cm2。
As a preferred technical scheme of the invention, the preparation type of the nanogold-based preparation is gel. More preferably, the preparation method of the gel comprises the following steps: and uniformly mixing the nano gold and the nano copper sulfide with the carbomer 980 solution, then adding butanediol with the volume being one fifth of that of the carbomer 980 solution, and stirring to obtain the gel.
According to a preferable technical scheme of the invention, the components of the beauty dressing further comprise 1, 2-hexanediol, sorbitan caprylate, glycerin and water, more preferably, the β -glucan accounts for 0.1-5% of the total weight of the beauty dressing, and the polypeptide accounts for 1-30% of the total weight of the beauty dressing.
The invention has the beneficial effects that:
the beautifying method can obviously improve the elasticity, wrinkle resistance and anti-aging property of the skin and can provide long-acting protection for the skin.
Drawings
FIG. 1 and FIG. 2 are graphs showing the anti-allergic effect of the present invention;
fig. 3 is a diagram of anti-wrinkle effect of the present invention.
Detailed Description
The present invention is described in detail below by way of examples, and it should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention.
Example 1
1.1 Main raw materials and preparations
Nano gold (particle size 120-200 nm, Walcarb (Beijing) Biotech limited Co.) and,Nano copper sulfide (particle size 120-200 nm, Shanghai ultra Wei nano technology Co., Ltd.), β -1, 3-dextran (Cefacai brand)
) Acetyl hexapeptide-8 (Sichuan Ji Cheng biological medicine Co., Ltd.), tetrapeptide 21 (Sichuan Ji Cheng biological medicine Co., Ltd.), carnosine (Sichuan Ji Cheng biological medicine Co., Ltd.), aminobutyric acid (Sichuan Ji Cheng biological medicine Co., Ltd.), conopeptide (Sichuan Ji Cheng biological medicine Co., Ltd.), acetyl hexapeptide-3 (Sichuan Ji Cheng biological medicine Co., Ltd.), palmitoyl pentapeptide-4 (Sichuan Ji Cheng biological medicine Co., Ltd.), palmitoyl pentapeptide-5 (Sichuan Ji Cheng biological medicine Co., Ltd.), tripeptide-1 copper (Sichuan Ji Cheng biological medicine Co., Ltd.), snake venom-like peptide (Sichuan Ji Cheng biological medicine Co., Ltd.), azone (Dong Longkou chemical assistant Co., Ltd.), menthol (Wuchuancheng Cheng Han scientific development Co., Ltd.), sodium cholate (Huaibei Bo Biochemical medicine Co., Ltd.), and sodium cholate (Huai Kagao Ka, Sodium lauryl sulfate (Tianjin Bodi chemical Co., Ltd.).
1.2 preparation of Nanogold-based gels
And (3) uniformly mixing 0.6g of nano gold and 0.1g of nano copper sulfide with 5.0ml of 10% carbomer 980 solution by weight, then adding 1.0ml of butanediol, and stirring to obtain the gel.
1.3 cosmetic procedure of the skin
(1) Coating the skin with 1% azone aqueous solution by weight, and after 10-15 seconds, washing with clear water and wiping the skin dry;
(2) coating the skin with the nanogold-based gel obtained in step 1.2, drying by breeze, and irradiating by using near infrared light with the wavelength of 980nm, wherein the laser intensity is 0.40W/cm2The irradiation time is 20 seconds;
(3) 5mL of a cosmetic dressing (β -1,3 dextran and an aqueous solution of acetyl hexapeptide-8, β -dextran representing 1% of the total weight of the cosmetic dressing, and acetyl hexapeptide-8 representing 10% of the total weight of the cosmetic dressing) was applied to the skin.
1.4 anti-allergic Property test
Subjects were free of skin disease, no visible erythema, sunburn, wounds, skin abrasion and tattoos, with 20 healthy women between 20 and 50 years of age who were positive for lactate challenge test. The subject received the skin cosmetic procedure described in 1.3 once a day.
And (3) testing period: 4 weeks.
The testing steps are as follows:
1) cleaning the face;
2) waiting for 15 minutes in the temperature control room;
3) VISIA-CR photograph;
4) skin stratum corneum moisture;
5) lactic acid stimulation test.
The instrument comprises the following steps: VISIA-CR, CM825, TM 300.
Test results of water content of stratum corneum:
TABLE 1
As shown in table 1, the average stratum corneum moisture content of 20 subjects was effectively increased to 72.44 after one week, indicating that the water retention of the skin was effectively improved after using the method of the present invention.
Lactic acid stimulation test:
the subject's nasolabial sulcus was subjected to the lactic acid stimulation test at week 0, week 2 and week 4 after the skin cosmetic procedure described in 1.3, respectively, and table 2 is a lactic acid stimulation score table:
TABLE 2
| Time of day | 0 point (min) | 1 minute (1) | 2 is divided into | 3 points of |
| 0.5 minute | Has no irritation | Mild stimulation | Moderate stimulation | Severe stimulation |
| 2.5 minutes | Has no irritation | Mild stimulation | Moderate stimulation | Severe stimulation |
| 5 minutes | Has no irritation | Mild stimulation | Moderate stimulation | Severe stimulation |
After the cosmetic method is used, the average score is reduced from 2.8 points at 0 week to 1.1 points at 4 weeks, which shows that the product has good anti-allergy effect.
In two subjects as an example, as shown in fig. 1 and 2, the left side of the graph is a photograph before treatment, and the right side of the graph is a photograph after treatment, it can be seen that the red area is significantly reduced after use, indicating that the present invention can significantly improve skin sensitivity.
1.5 anti-wrinkle test
Testing the population: 30 women, age 30-40 years old; the subjects had no skin disease and no history of skin allergy.
Design of control group: control group 1: part 1.3, except for step (1) where part 1.3 is not used; control group 2: the cosmetic dressing in 1.3 was applied only twice in the morning and evening.
Subjects were divided into three groups, one group treated once a day in the morning and evening with 1.3 part of the cosmetic method, one group treated with control 1 in the morning and evening, one group treated with control 2, and skin elasticity tests were performed after 1 week, 2 weeks, 3 weeks, and 4 weeks. The used test instruments are CotomermerMPA 580 host and RevistometerRV 600 probe of Courage + Khazaka company, Germany, when carrying out the test, 5 times of averaging are measured, the test areas are the forehead area which is 2cm upward from the center of the eyebrow, the chin area which is 2cm downward from the center of the lower lip, the left cheek area and the right cheek area at the intersection line of the nose tip and the pupil, and the elasticity indexes R2, R5 and R7 are measured (the negative pressure is constant at 450mbar in the test process)
The skin elasticity Cotomerma MPA580 host manufactured by Courage + Khazaka, Germany (CK, Germany) was used, the probe used was a Reviscometer RV600 elasto-fibrous tissue test probe, and the average was taken five times. Test area: the forehead area 2cm above the middle of the eyebrow, the chin area 2cm below the middle of the lower lip, and the left and right cheek areas at the intersection of the nose tip and the pupil. The blank values (R2, R5, R7) of the test areas after cleaning for 30min were measured, and then the subjects were prescribed to use the above test articles on a daily basis for testing the skin elasticity index R2, R5, R7 values of the test areas after 1 week, 2 weeks, 3 weeks, 4 weeks, respectively (the negative pressure during the test was constant at 450 mbar).
Specification of indexes: the closer the skin elasticity indexes R2, R5, R7 are to 1, the better the elasticity of the skin.
R2＝Ua/Uf；R5＝Ur/Ue；R7＝Ur/Uf
Uf-maximum amount of skin stretching
Ue-the amount of skin stretch at 0.1 second after a constant negative pressure is applied to the skin, positioning the amount of stretch in the elastic portion.
Ur-after negative pressure is removed, the skin will quickly recover to the original state, and the values are also divided into elastic part value Ur, namely, after negative pressure is removed for 0.1 second, the recovery value and the viscoelastic part value, or the plastic part value, of the skin.
Ua-the recovery value of the skin from the elimination of the negative pressure to the next successive test of the skin surface plus the negative pressure.
The results of the experiments are shown in tables 3, 4 and 5. The subjects in table 3 used 1.3 part of the cosmetic treatment method, the subjects in table 4 used control 1, and the subjects in table 5 used control 2.
TABLE 3
| Test time (week) | R2 | R5 | R7 |
| 0 | 0.5112 | 0.4736 | 0.4555 |
| 1 | 0.6245 | 0.6923 | 0.5841 |
| 2 | 0.7561 | 0.7697 | 0.6977 |
| 3 | 0.8894 | 0.8236 | 0.7635 |
| 4 | 0.9563 | 0.9012 | 0.8654 |
TABLE 4
| Test time (week) | R2 | R5 | R7 |
| 0 | 0.5231 | 0.4755 | 0.4539 |
| 1 | 0.5566 | 0.4956 | 0.4786 |
| 2 | 0.6134 | 0.5000 | 0.5233 |
| 3 | 0.6698 | 0.5832 | 0.6012 |
| 4 | 0.7013 | 0.6454 | 0.6428 |
TABLE 5
| Test time (week) | R2 | R5 | R7 |
| 0 | 0.5298 | 0.4713 | 0.4588 |
| 1 | 0.5433 | 0.4900 | 0.4721 |
| 2 | 0.60.01 | 0.49.77 | 0.5147 |
| 3 | 0.6537 | 0.5623 | 0.5866 |
| 4 | 0.6822 | 0.6339 | 0.6203 |
As shown in table 3, the cosmetic method of the present invention has very excellent anti-wrinkle and anti-aging effects, and can enhance the elasticity of the skin. As can be seen from tables 4 and 5, the anti-wrinkle effect of acetyl hexapeptide-8 was not improved well by the control group 1 alone without the step (1) of the present invention.
Fig. 3 is a comparison before and after use of a subject treated with 1.3 part of the cosmetic treatment, wherein a picture of Visa before use is shown on the left side and a picture of Visa after use is shown on the right side, and a significant reduction in wrinkles after use can be seen.
Example 2
Experiments consistent with example 1 were performed by replacing acetyl hexapeptide-8 of example 1 with acetyl hexapeptide-3, tetrapeptide 21, carnosine, aminobutyric acid, conopeptide, palmitoyl pentapeptide-4, palmitoyl pentapeptide-5, tripeptide-1 copper, and snake venom like peptide, respectively. The values obtained at week 4 corresponding to Table 3 do not differ by more than 12%.
Comparative example 1
The anti-wrinkle test of section 1.5 in example 1 was performed for each of the three protocols, except that the three protocols were composed of menthol, sodium cholate, and sodium lauryl sulfate instead of azone in section 1.3 in example 1, respectively. The results of the tests show that the values of R2, R5 and R7 do not increase by more than 10% at week 4 after the respective wrinkle resistance tests of the three protocols compared to the corresponding values obtained for control 1 of example 1.
Claims (7)
1. A cosmetic method for non-invasive wrinkle removal and anti-aging, comprising the steps of:
(1) coating the skin with 1% azone aqueous solution by weight, and after 10-15 seconds, washing with clear water and wiping the skin dry;
(2) coating the skin with the nanogold-based preparation, and after drying, irradiating the skin with near infrared light with the wavelength of 980nm, wherein the laser intensity is 0.35-0.40W/cm2The irradiation time is 15-20 seconds;
(3) applying a beauty dressing, wherein the beauty dressing comprises β -1,3 glucan and polypeptide, wherein the weight ratio of β -1,3 glucan to polypeptide is 1: 2-10;
the polypeptide is any one of acetyl hexapeptide-8, acetyl hexapeptide-3, tetrapeptide 21, carnosine, aminobutyric acid, conopeptide, palmitoyl pentapeptide-4, palmitoyl pentapeptide-5, tripeptide-1 copper and snake venom like peptide;
in the nano gold-based preparation, a nano gold base consists of nano gold and nano copper sulfide, and the weight ratio of the nano gold to the nano copper sulfide is 6: 1; the preparation type of the nano-gold-based preparation is nano-particle solution or gel.
2. The cosmetic method according to claim 1, wherein the nano gold and the nano copper sulfide each have a particle size of 120 to 200 nm.
3. Cosmetic method according to claim 1, characterized in that said laser intensity is 0.40W/cm2。
4. The cosmetic method according to claim 1, wherein the formulation type of the nanogold-based formulation is a gel.
5. Cosmetic method according to claim 4, characterized in that said gel is prepared by: and uniformly mixing the nano gold and the nano copper sulfide with the carbomer 980 solution, then adding butanediol with the volume being one fifth of that of the carbomer 980 solution, and stirring to obtain the gel.
6. The cosmetic method according to claim 1, wherein the ingredients of the cosmetic dressing further comprise 1, 2-hexanediol, sorbitan caprylate, glycerin and water.
7. The cosmetic method according to claim 6, wherein the β -glucan is 0.1-5% of the total weight of the cosmetic dressing, and the polypeptide is 1-30% of the total weight of the cosmetic dressing.
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| KR102281606B1 (en) * | 2021-04-16 | 2021-07-26 | (주)바이오신펩 | A multifunctional cosmetic composition for elasticity, anti-wrinkle, inhibiting tyrosinase comprising peptide complex |
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| KR102281606B1 (en) * | 2021-04-16 | 2021-07-26 | (주)바이오신펩 | A multifunctional cosmetic composition for elasticity, anti-wrinkle, inhibiting tyrosinase comprising peptide complex |
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Application publication date: 20200306 |