CN110192997B

CN110192997B - Skin care lotion and preparation method thereof

Info

Publication number: CN110192997B
Application number: CN201910609450.3A
Authority: CN
Inventors: 王澍
Original assignee: Hangzhou Yuexuantang Cosmetics Co ltd
Current assignee: Hangzhou Yuexuantang Cosmetics Co ltd
Priority date: 2019-07-08
Filing date: 2019-07-08
Publication date: 2020-11-24
Anticipated expiration: 2039-07-08
Also published as: CN110192997A

Abstract

The invention discloses a skin lotion, which comprises the following components in percentage by mass: 5-28% of polyalcohol, 0.02-2% of methyl glucose humectant, 0.05-3% of disaccharide humectant, 0.301-3.3% of repairing agent, 0.05-0.5% of sodium hyaluronate and the balance of water; wherein the repairing agent comprises yeast extract and polysaccharide derivatives. The invention also provides a preparation method of the skin moisturizer, which comprises the steps of mixing the raw materials in parts according to a proportion, cooling and mixing to prepare the skin moisturizer. The skin moisturizer has a strong moisturizing effect, and maintains good texture and comfortable use feeling; meanwhile, the preparation method of the skin lotion is simple and controllable, and the cost is effectively saved.

Description

Skin care lotion and preparation method thereof

Technical Field

The invention relates to the field of cosmetics, in particular to a skin moisturizer and a preparation method thereof.

Background

With the increase of physiological age of people, under the combined action of factors such as physiological mechanisms inherent in human aging, external UV radiation, environmental pollution and the like, the skin is gradually aged, and the skin aging is usually reflected in the aspects of skin elasticity reduction, wrinkle generation and the like. Therefore, in daily life, people use skin care products to maintain the skin.

The skin moisturizer is the basis for keeping skin moisturized, and the existing skin moisturizers are numerous, but part of the skin moisturizers are poor in moisturizing effect and water locking effect, and part of the skin moisturizers are poor in use feeling, too viscous, or poor in extensibility and are difficult to feel moisturized and moisturized.

The yeast extract is a substance which is rich in natural active ingredients such as micromolecular amino acid, peptide, nucleotide, vitamin and the like, is obtained by extracting protein, nucleic acid, vitamin and the like in yeast after wall breaking and then carrying out biological enzymolysis. Wherein, the amino acid content is more than 30 percent, the total protein is more than 50 percent, and the nucleotide content is more than 10 percent, and the preparation method is mainly applied to the fields of food, seasonings, cosmetics and the like.

In the field of cosmetics, the yeast extract is directly mixed with other raw materials, but how to further improve the availability of the yeast extract is also a great problem in the prior art.

Therefore, those skilled in the art are devoted to provide a skin moisturizer and a preparation method thereof, which can promote the utilization rate of the effective components of the yeast extract on the basis of providing better skin moisturizing effect.

Disclosure of Invention

In view of the above-mentioned drawbacks of the prior art, it is an object of the present invention to provide a skin moisturizer which has a strong moisturizing effect and is easily absorbed while maintaining good texture and pleasant feeling of use, and a method for preparing the same, so as to improve the above-mentioned problems.

In order to achieve the purpose, the invention provides a skin moisturizer which comprises the following components in percentage by mass: 5-28% of polyalcohol, 0.02-2% of methyl glucose humectant, 0.05-3% of disaccharide humectant, 0.301-3.3% of repairing agent, 0.05-0.5% of sodium hyaluronate and the balance of water.

Wherein the repairing agent comprises yeast extract and polysaccharide derivatives.

According to the technical scheme, the polyhydric alcohol is used as the main humectant, the proper amount of the methyl glucose humectant and the proper amount of the disaccharide humectant are added, the humectant, the polyhydric alcohol and the yeast extract together enhance the moisturizing effect, and meanwhile, due to the proper addition amount of the methyl glucose humectant, the disaccharide humectant and the polysaccharide derivative, the problems of viscosity and poor use feeling of the skin moisturizer are avoided through reasonable proportion, and the problem of excessive transparency and volatility of the skin moisturizer is also avoided. Meanwhile, the polyhydric alcohol, the methyl glucose humectant and the disaccharide humectant can be effectively mixed and dissolved in water, so that the moisturizing effect is more uniform.

The disaccharide humectant belongs to natural saccharides, is a micromolecular humectant, has good affinity with membrane protein, can be used as a skin penetrating agent to increase the absorption of skin on nutrient components and increase the hydration function of cells, has good moisture retention, and can improve the utilization rate and improve the effects of repairing, compacting and resisting aging by matching with yeast extracts and the like.

The yeast extract of the present invention includes not only a hydrolyzed yeast extract obtained by hydrolyzing yeast but also a yeast extract obtained by extracting yeast by fermentation. The hydrolyzed yeast extract is natural active ingredients obtained by extracting protein, nucleic acid, vitamins and the like after wall breaking and then performing biological enzymolysis. The yeast extract contains rich natural amino acids and various nutrient components with cell proliferation effect, so as to achieve the purposes of accelerating the regeneration of aged stratum corneum cells, resisting aging and repairing, and has good safety and stability.

The polysaccharide derivative has the advantages that hydroxyl, carboxyl and other polar groups in polysaccharide molecules can form hydrogen bonds with water molecules, so that a large number of water molecules are combined to play a role in water retention, and meanwhile, molecular chains of the polysaccharide derivative can be interwoven to form a net, so that the water-supplementing and moisture-retaining effect is good, meanwhile, the polysaccharide derivative has a certain film-forming property, the evaporation of water can be effectively prevented, the water-locking effect is good, the contact time of a yeast extract and the skin is prolonged, the absorption of the yeast extract by the skin is promoted through the permeation-promoting effect of trehalose and dipropylene glycol, and the anti-aging and repairing effects are improved. Wherein the polyhydric alcohol comprises at least one of sugar alcohol, dipropylene glycol, butanediol, glycerol, diglycerol and 1, 2-pentanediol; the sugar alcohol includes xylitol, sorbitol, etc.

In actual use, different specific polyol combinations have different actual moisturizing effects, and optionally, in some embodiments of the present invention, the polyol includes dipropylene glycol, butylene glycol, and sugar alcohol in the following mass ratio of (2.5-7) (5-8.5) (0.05-3).

Alternatively, the sugar alcohol comprises xylitol.

Under the condition of the proportion, the moisturizing effect is good, and the use feeling is good, wherein the butanediol is mild in texture, increases the smoothness of the product, can effectively loosen cutin, has good hygroscopicity, retains water in the cuticle and also has a certain antibacterial effect; the dipropylene glycol is soluble in water, colorless, odorless, water-soluble and hygroscopic, has small irritation to skin and good moisturizing effect, and can effectively promote other components, such as water, butanediol and the like to enter the loosened cutin, accelerate the penetration into the skin and improve the moisturizing effect; the xylitol has good moisture-keeping ability, no greasy and sticky feeling like glycerin, and improved use comfort, and can effectively prevent water evaporation by combining with various humectant and polysaccharide derivatives.

Optionally, the methylglucose-based humectant comprises methylglucoside polyether-20. The skin moisturizer has good moisturizing effect, and meanwhile, the skin moisturizer has smoother texture and improves the use comfort.

Optionally, the disaccharide based humectant comprises trehalose.

Wherein, the trehalose is a micromolecular humectant, has good affinity with membrane protein, can cooperate with dipropylene glycol, has good permeation promoting effect, and can promote the absorption of skin on nutrient components. Meanwhile, the skin care product has the moisture retention capacity, increases the hydration function of cells, and relieves scurf increase, dryness heat, keratosclerosis and the like caused by dry skin. Meanwhile, the trehalose also has a certain film forming effect, so that the evaporation of water is reduced, the water is dispersed to the stratum corneum from the basal tissue, and the stratum corneum is induced to be further hydrated.

Since the addition of the polysaccharide derivative to a large extent causes the skin care liquid to become viscous and the feeling of use to be poor, in some examples shown in the present invention, the mass ratio of the addition amount of the yeast extract to the addition amount of the polysaccharide derivative is (0.3 to 3): (0.001-0.3).

Optionally, the polysaccharide derivative comprises chitosan mono succinamide. The chitosan mono-succinamide has better film-forming and firming effects, has antibacterial ability, is matched with butanediol to prolong the shelf life of the skin care lotion, and can promote the regeneration of stratum corneum cells and the repair effect together by the synergy of the chitosan mono-succinamide and the yeast extract.

In an alternative embodiment of the present invention, the lotion further comprises one or more of a thickening agent, a preservative, a pH adjusting agent, a chelating agent, and an emulsifier.

Optionally, the thickening agent comprises carbomer.

Further optionally, the addition amount of the thickening agent accounts for 0.09-0.11% of the skin lotion by mass. The thickening agent can be added according to the actual use requirement, so that the use feeling of the skin care lotion is adjusted, and the use requirements of different consumers are met.

Optionally, the preservative comprises at least one of phenoxyethanol and methylparaben.

Further optionally, the addition amount of the preservative accounts for 0.2-0.35% by mass of the skin moisturizer.

Optionally, the pH adjuster comprises potassium hydroxide.

Further optionally, the addition amount of the pH regulator accounts for 0.02-0.035% of the skin moisturizer by mass.

Optionally, the chelating agent comprises disodium EDTA.

Further optionally, the addition amount of the chelating agent accounts for 0.02-0.035% of the skin moisturizer by mass.

Optionally, the emulsifier comprises polysorbate 20.

Further optionally, the addition amount of the emulsifier accounts for 1-2% by mass of the skin moisturizer.

In an optional embodiment of the invention, the skin moisturizer further comprises a natural extract, wherein the natural extract is added in an amount of 0.3-0.65% by mass of the skin moisturizer, and further optionally, the natural extract comprises at least one of verbena extract, moringa oleifera seed extract and salvia officinalis leaf extract.

The verbena extract is rich in various alcohols, such as beta-sitosterol, verbena glycoside and the like, and has the effects of resisting inflammation, reducing swelling, promoting blood circulation, moistening skin, nourishing and brightening skin; the moringa oleifera seed extract has a lotus effect, reduces pollutants attached to the surface of the skin, protects cells, resists the poison of heavy metals and has a protective effect on the skin; the sage herb leaf extract has the effects of relieving, conditioning and resisting oxidation on skin; the natural extracts are selectively or synergistically used, have good effects of sterilizing and protecting skin, and generate synergistic effect on the aspects of rough skin quality improvement and skin tenderness change effects together with other raw materials.

In another aspect, the invention provides a preparation method of the skin lotion, which comprises the following steps:

mixing polyalcohol, methyl glucose humectant, disaccharide humectant, repairing agent, sodium hyaluronate and water.

Through the technical scheme, the preparation process is simple, the operation is controllable, and the labor cost is reduced.

In an alternative embodiment of the invention, the step of mixing comprises:

mixing part of water, part of polyol, disaccharide humectant methyl glucose humectant and sodium hyaluronate, and heating to 80-85 ℃ to obtain a first mixed solution.

Mixing the rest water, the rest polyalcohol and the repairing agent with the first mixed solution cooled to 36-40 ℃, and cooling to 20-35 ℃.

When natural extracts are contained, further, the step of mixing comprises:

mixing part of water, part of polyol, disaccharide humectant, methyl glucose humectant and sodium hyaluronate, and heating to 80-85 ℃ to obtain a first mixed solution.

Mixing the rest water, the rest polyalcohol, the repairing agent and the natural extract with the first mixed solution cooled to 36-40 deg.C, and cooling to 20-35 deg.C.

In the technical scheme, the raw materials can be fully and uniformly mixed by adopting a step-by-step mixing mode, and simultaneously the raw materials are heated to 80-85 ℃, so that part of water, part of polyol, disaccharide humectant and methyl glucose humectant can be fully and uniformly mixed in the step, and the materials are homogenized. The repairing agent can be dissolved in other raw materials at 36-40 ℃, and simultaneously, the performance of the repairing agent is ensured not to be changed.

In an optional embodiment of the invention, the skin moisturizer further comprises a pH regulator accounting for 0.02-0.035% of the skin moisturizer by mass, and the mixing step comprises:

mixing part of water, part of polyol, disaccharide humectant and methyl glucose humectant, and heating to 80-85 deg.C to obtain a second mixed solution;

mixing part of water and a pH regulator, and heating to 80-85 ℃ to obtain a third mixed solution;

mixing the rest water, the rest polyalcohol, the repairing agent, the second mixed solution cooled to 36-40 ℃ and the third mixed solution cooled to 36-40 ℃, and cooling to 20-35 ℃.

In the technical scheme, the raw materials can be fully and uniformly mixed by adopting a step-by-step mixing mode.

The invention has the following beneficial effects:

(1) the skin moisturizer has a strong moisturizing effect, and maintains good texture and comfortable use feeling;

(2) the yeast extract and chitosan mono-succinamide have synergistic effect, so that the anti-aging effect is effectively promoted; the trehalose and the dipropylene glycol have synergistic effect, and are beneficial to promoting the absorption of the yeast extract;

(3) the preparation method provided by the invention is simple and controllable, and effectively saves the cost.

The conception, specific structure and technical effects of the present invention will be further described in conjunction with the embodiments below, so that the objects, features and effects of the present invention can be fully understood.

Drawings

FIG. 1 is a graph showing the trend of the effect of example samples of skin moisturizers of the present invention on the moisture content of skin in skin moisturization tests.

FIG. 2 is a graph showing the trend of moisture evaporation from the epidermis of an example sample of the skin moisturizer of the present invention in a skin moisturizing test.

Detailed Description

The invention provides a skin moisturizer which comprises the following components in percentage by mass: 5-28% of polyalcohol, 0.02-2% of methyl glucose humectant, 0.05-3% of disaccharide humectant, 0.301-3.3% of repairing agent, 0.05-0.5% of sodium hyaluronate and the balance of water.

It should be noted that, in the above raw material composition, the components other than water are the main components of the raw material, but in some other embodiments, the raw material may optionally further include a part of the auxiliary components. The mass percentage of the balance water in the raw material means the balance of the raw material excluding the mass percentage of the above-mentioned main component and the mass percentage of the auxiliary material component which may be contained.

In some alternative embodiments, the repair agent comprises yeast extract and polysaccharide derivatives, and the mass percentage of the repair agent in the raw material is, for example, but not limited to, 0.301%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.3%, or a range between any two of these values.

Alternatively, in some illustrative embodiments of the invention, the polyol comprises dipropylene glycol, butylene glycol, and a sugar alcohol in a mass ratio of (2.5-7): 5-8.5): 0.05-3, respectively. Illustratively, the ratio of dipropylene glycol, butanediol, and sugar alcohol is 3:5:2, and the total mass percentage in the raw materials is, for example, but not limited to, 5%, 6%, 8%, 10%, 15%, 20%, 25%, 28%, or a range between any two of them.

Further optionally, the sugar alcohol comprises xylitol. Illustratively, the polyol consists of dipropylene glycol, butylene glycol, and xylitol in a mass ratio of 3:5:0.5, in that order.

Optionally, the methylglucose-based humectant comprises methylglucoside polyether-20. Illustratively, the mass percent of methyl glucitol polyether-20 in the starting material is, for example, but not limited to, any of 0.02%, 0.05%, 0.1%, 0.12%, 0.15%, 2%, or a range of values between any two.

Optionally, the disaccharide based humectant comprises trehalose. Illustratively, the mass percentage of trehalose in the feedstock is, for example, but not limited to, any of 0.05%, 0.1%, 0.15%, 0.3%, 0.5%, 1.5%, 2%, 2.5%, 3%, or a range between any two of these.

Sodium hyaluronate is used as a humectant in the skin lotion of the present invention. Sodium hyaluronate is a powerful humectant, naturally exists in corneal endothelium, can absorb 1000 times of water by weight of the sodium hyaluronate, and is one of the best humectants at present. The sodium hyaluronate is matched with other moisturizers for use, so that the moisturizing effect of the skin moisturizer can be improved, and moisture can be locked for the skin, so that the skin is more moist after makeup removal and interface treatment.

In some illustrative examples of the present invention, the mass ratio of the amount of the yeast extract added to the amount of the polysaccharide derivative added is (0.3-3): (0.001-0.3).

In some possible embodiments, yeast extract is a broad concept that includes yeast extract that is not hydrolyzed as well as hydrolyzed yeast extract. The kind of the polysaccharide derivative is not particularly limited, and may be, for example, chitosan monosuccinamide.

Optionally, the thickener comprises carbomer, and the addition amount of the thickener accounts for 0.09-0.11% of the mass of the lotion.

Optionally, the preservative comprises at least one of phenoxyethanol and methylparaben, and the additive amount of the preservative accounts for 0.2-0.35% of the skin moisturizer by mass.

Optionally, the pH regulator comprises potassium hydroxide, and the addition amount of the pH regulator accounts for 0.02-0.035% by mass of the skin moisturizer.

Optionally, the chelating agent comprises disodium EDTA, and the addition amount of the chelating agent accounts for 0.02-0.035% of the skin care lotion.

Optionally, the emulsifier comprises polysorbate 20, and the addition amount of the emulsifier accounts for 1-2% of the skin lotion by mass.

On the other hand, the invention also provides a preparation method of the skin moisturizer, which comprises the following steps:

mixing polyalcohol, methyl glucose humectant, disaccharide humectant, repairing agent, sodium hyaluronate and water. Wherein, the raw materials comprise the following components in percentage by mass: 5-28% of polyalcohol, 0.02-2% of methyl glucose humectant, 0.05-3% of disaccharide humectant, 0.301-3.3% of repairing agent, 0.05-0.5% of sodium hyaluronate and the balance of water.

It should be noted that, if there is no specific description on the raw materials used in the preparation method of the skin moisturizer, such as the polyhydric alcohol, the methyl glucose humectant, the disaccharide humectant, the repairing agent, etc., the specific types and amounts thereof can be explained by the explanation on the raw materials in the skin moisturizer examples, and are not described herein again.

In an alternative embodiment of the invention, the step of mixing comprises:

When natural extracts are contained, further, the step of mixing comprises:

And cooling to obtain a semi-finished product, and filling and packaging to obtain a finished product.

The products and effects of the lotions provided by the present invention are further described below in connection with several examples and performance evaluations.

Example 1

A skin moisturizer, which comprises the following components in percentage by mass: 8.5% of polyalcohol, 0.05% of methyl glucose humectant, 0.05% of disaccharide humectant, 0.7% of repairing agent, 0.1% of carbomer, 0.03% of potassium hydroxide, 0.3% of phenoxyethanol, 0.05% of sodium hyaluronate and the balance of water.

The skin care lotion comprises, by mass, 3% of dipropylene glycol, 5% of butanediol and 0.5% of xylitol, wherein the polyhydric alcohols comprise, by mass, 3% of dipropylene glycol, 5% of butanediol and 0.5% of xylitol.

The repairing agent comprises yeast extract and chitosan mono-succinamide in a mass ratio of 0.5:0.2, namely the skin care liquid comprises 0.5% of the yeast extract and 0.2% of the chitosan mono-succinamide in percentage by mass.

The skin moisturizer is prepared by the following steps:

(1) mixing part of water, part of butanediol, dipropylene glycol, xylitol, methyl glucitol polyether-20, trehalose, sodium hyaluronate and carbomer, and heating to 80-85 ℃ to obtain a second mixed solution;

(2) mixing part of water and potassium hydroxide, and heating to 80-85 ℃ to obtain a third mixed solution;

(3) stirring and mixing the rest water, the rest polyalcohol, the yeast extract, chitosan mono-succinamide, the second mixed solution cooled to 36-40 ℃ and the third mixed solution cooled to 36-40 ℃, stirring and cooling to 20-35 ℃.

The content of water in the steps (1), (2) and (3) is not limited, as long as the water in the corresponding step can dissolve the corresponding material. The same applies to the amount of butanediol added in step (1) (3).

Examples 2 to 4

Examples 2-4 all provide a skin lotion which differs from example 1 in the composition of the raw materials in that the composition content is different. In example 4, sodium hyaluronate was not added.

The preparation methods of examples 2 to 4 were the same as those of example 1.

Example 5

Example 5 provides a skin lotion which differs from example 1 in that it does not contain dipropylene glycol.

The skin moisturizer is prepared by the following steps:

(1) mixing part of water, part of butanediol, part of xylitol, methyl glucitol polyether-20, trehalose, sodium hyaluronate and carbomer, and heating to 80-85 ℃ to obtain a second mixed solution;

(3) stirring and mixing the rest water, the rest butanediol, the rest xylitol, the yeast extract, the chitosan mono-succinamide, the second mixed solution cooled to 36-40 ℃ and the third mixed solution cooled to 36-40 ℃, stirring and cooling to 20-35 ℃.

Example 6

Example 6 provides a skin lotion which is different from example 1 in that trehalose is not contained.

The skin moisturizer is prepared by the following steps:

(1) mixing part of water, part of butanediol, dipropylene glycol, xylitol, methyl glucitol polyether-20, sodium hyaluronate and carbomer, and heating to 80-85 ℃ to obtain a second mixed solution;

The formulations of examples 1-6 are shown in Table 1

Table 1: examples 1-6 feed Components

Content of Components (wt.%)	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6
							Dipropylene glycol	3	7	6	4.5	-	3
Butanediol	5	8.5	4.5	6.5	5	5
							Xylitol, its preparation method and use	0.5	3	0.05	1.8	0.5	0.5
Methylglucitol polyether-20	0.05	1	2	0.02	0.05	0.05
							Trehalose	0.05	2	3	0.65	0.05	-
Yeast extract	0.5	3	1.5	0.3	0.5	0.5
							Chitosan mono-succinamide	0.2	0.3	0.2	0.001	0.2	0.2
Carbomer	0.1	0.1	0.1	0.1	0.1	0.1
							Potassium hydroxide	0.03	0.03	0.03	0.03	0.03	0.03
Phenoxyethanol	0.3	0.3	0.3	0.3	0.3	0.3
							Hyaluronic acid sodium salt	0.05	0.5	0.2	-	0.05	0.05
Water (W)	Balance of	Balance of	Balance of	Balance of	Balance of	Balance of

Example 7

Example 7 provides a skin moisturizer, which is different from the raw materials of example 1 in that the skin moisturizer further comprises the following components in percentage by mass: herba Verbenae extract 0.3%.

Example 8

Embodiment 8 provides a skin moisturizer, which is different from the raw materials of embodiment 1 in that the skin moisturizer further comprises the following components in percentage by mass: 0.3 percent of verbena extract and 0.3 percent of moringa oleifera seed extract.

Example 9

Example 9 provides a skin moisturizer, which is different from the raw materials of example 1 in that the skin moisturizer further comprises the following components in percentage by mass: 0.5 percent of moringa oleifera seed extract and 0.15 percent of salvia officinalis leaf extract.

Example 10

Example 10 provides a skin moisturizer, which is different from the raw materials of example 1 in that the skin moisturizer further comprises the following components in percentage by mass: 0.6 percent of winged seed moringa seed extract.

Example 11

Example 11 provides a skin moisturizer, which is different from the raw materials of example 1 in that the skin moisturizer further comprises the following components in percentage by mass: 0.2 percent of verbena extract, 0.2 percent of moringa oleifera seed extract and 0.2 percent of salvia officinalis leaf extract.

Example 12

Example 12 provides a skin moisturizer, which is different from the raw materials of example 1 in that the skin moisturizer further comprises the following components in percentage by mass: 0.5 percent of sage herb leaf extract.

The lotions of examples 7-12 were prepared by the following procedure:

(3) mixing the rest water, the rest polyalcohol, the yeast extract, chitosan mono-succinamide, the natural extract, the second mixed solution cooled to 36-40 deg.C, and the third mixed solution cooled to 36-40 deg.C, stirring, and cooling to 20-35 deg.C.

The formulations of examples 7-12 are shown in Table 2

Table 2: examples 7-12 feed Components

Examples 13 to 21

Examples 13-21 based on example 1, the amount of the rejuvenating agent (including the case of removing yeast extract or chitosan mono-succinamide) was adjusted, while the balance of water was adjusted to ensure that the raw material content of the skin lotion was 100%.

The preparation methods of examples 13 to 21 were the same as those of example 1.

The formulations of examples 13-21 are shown in Table 3.

Table 3: examples 13-21 feed Components

Control groups 1 to 3

The control groups 1-3 all provided a commercially available skin lotion having the raw material composition shown in Table 4.

Table 4: reference groups 1-3 raw material components

Content of Components (wt.%)	Control group 1	Control group 2	Control group 3
				Dipropylene glycol	3	7	7
Butanediol	5	8	8
				Glycerol	2	2	2
Hyaluronic acid sodium salt	0	0.01	0.05
				Carbomer	0.1	0.1	0.1
Potassium hydroxide	0.03	0.03	0.03
				Phenoxyethanol	0.3	0.3	0.3
Water (W)	Balance of	Balance of	Balance of

Test examples

Test example 1: evaluation of product safety

1. The test substance: skin lotion samples of each example (examples 1-21);

2. comparison: commercial skin lotion products of control groups 1-3;

3. subject: selecting 120 volunteers with the ages of 30-40 years and the male-female ratio of 2:3 for trial experiment;

4. the spot pasting method comprises the following steps: two samples are distributed to each volunteer for test, about 0.020ml to 0.025ml of the tested sample is dripped into a spot tester by a closed spot test method, an external special adhesive tape is pasted on the back of the testee, the tested sample is removed after 24 hours, the skin reaction is observed after 0.5 hour, 24 hours and 48 hours after the tested sample is removed respectively, and the result is recorded according to the skin reaction grading standard in the cosmetic hygiene code (2007 edition). The results were grouped with the control group according to this example.

The test results are shown in Table 5:

TABLE 5 test results of human skin patches

Human skin patch test table 5 results show that: adverse reactions to skin appear in 0 cases, which indicates that the product is safe to use.

Test example 2: skin application and elasticity test

1. The test substance: examples 1-4, examples 7-12;

2. comparison: commercial skin lotion products of control groups 1-3;

3. subject: 130 volunteers with age distribution of 30-40 years and male-female ratio of 2:3 are selected for trial experiment, 10 samples of the same kind are randomly used, and each sample is required to be used once in the morning, in the middle and at night and is smeared on the back of the hand until the skin moisturizer is completely absorbed. For each user, a skin tester (Derma-Expert MC760) was used for 10 days, and the changes in skin elasticity and skin friction were measured after use.

Meanwhile, according to the use experience scores of users, the scoring grades are as follows, namely from very good to very bad five grades, namely very good 5, good 4, common 3, bad 2 and very bad 1.

The test results are shown in Table 6:

TABLE 6 evaluation of human skin application

Through the test, the using effect of the skin moisturizer provided by the invention is better than that of the skin moisturizer sold in the market, and the using feeling and the moisturizing rate are improved, namely, the skin moisturizer provided by the application is proved to be capable of effectively improving the using feeling and the moisturizing rate according to reasonable raw materials and proportion thereof and reasonable selection and mutual cooperation of the polyhydric alcohol, the methyl glucose humectant and the disaccharide humectant, and the skin moisturizer is good in using feeling, not sticky, not too clear and volatile. Furthermore, it can be seen from the results of examples 7 to 12 that the skin lotions provided in examples 6, 7, 9 and 10 were better evaluated, that is, the natural extracts were added to produce synergistic effects in improving rough skin and changing skin tenderness.

Test example 3: skin moisture retention test

1. The test substance: examples 1-4 each sample;

2. the test method comprises the following steps: the samples of the examples were applied to the back of the hand until the skin moisturizer was completely absorbed, and the moisture content of the skin was continuously monitored using a portable moisture elasto-oleo-photo skin tester (Huntkey), wherein the applied part was used as a reference and the value corresponding to the non-applied part was always set to 100 to calculate the relative change ratio of moisture, and the results are shown in fig. 1 and 2.

FIG. 1 is a graph showing the trend of the effect of example samples of the cream of the present invention on the moisture content of skin in a skin moisturization test; FIG. 2 is a graph showing the trend of the moisture volatilization amount of the skin from the epidermis of the example of the cream of the present invention in the skin moisturizing test. According to the test results, each humectant contained in the facial cream has a good maintenance effect on the moisture content of the skin, and the comparison of the example 4 shows that the sodium hyaluronate and other humectants have synergistic effect and can obviously improve the moisturizing performance.

Test example 4 wrinkle removal test

1. The test substance: samples of the products of examples 5-6, examples 13-21;

2. comparison: commercial skin lotion products of control groups 1-3;

3. subject: randomly selecting 140 healthy population cases of 30-40 years old as volunteers, wherein the volunteers have no serious system diseases, no immunodeficiency or autoimmune diseases and no active allergic diseases, have no serious allergic history to skin care cosmetics, have no hormone medicines or immunosuppressants in nearly 1 month, have no other clinical tests, have no external preparations such as cosmetics and the like, have symptoms such as fine lines or wrinkles and the like on the skin around the eyes of the volunteers, and are randomly divided into 14 groups of 10 persons in each group;

4. the test method comprises the following steps:

after the test subjects cleansed their eyes, the test samples were applied to the eye circumference once in the morning and once in the evening. Changes in periocular wrinkle parameters were recorded for subjects before trial and one month after use, and averaged for each group.

The wrinkles of the skin around the eyes of the subject were tested using a skin wrinkle tester (VISIOMETER SV600, available from courage and Khazaka, collagen, Germany), including the average roughness (arithmetic mean of 5 consecutive, different, separate portions of the same length) and the number and depth of wrinkles.

The effect of each sample was evaluated according to the average roughness change value and the number of wrinkles and the percentage of depth reduction of each group of subjects. The results are shown in Table 7.

Table 7 skin lotions skin wrinkle reduction test results

The results of the wrinkle removal test can be used to obtain: for examples 5 and 6, the anti-aging effect was not well exerted even with the addition of the repairing agents (yeast extract and chitosan mono-succinamide) due to the lack of one of dipropylene glycol or trehalose in the raw materials, while for examples 16 to 18, which are clearly superior to the other groups, it can be seen that yeast extract and chitosan mono-succinamide act synergistically to effectively promote the anti-aging effect. The wrinkle removing effect of the samples is better than that of the control group, and compared with the skin moisturizer sold in the market, the effect is outstanding through the preparation component of the invention.

The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims

1. The skin moisturizer is characterized by comprising the following components in percentage by mass: 3% of dipropylene glycol, 5% of butanediol, 0.5% of xylitol, 200.05% of methyl glucitol polyether, 0.05% of trehalose, 0.3% of yeast extract, 0.001% of chitosan mono-succinamide, 0.1% of carbomer, 0.03% of potassium hydroxide, 0.3% of phenoxyethanol, 0.05% of sodium hyaluronate and the balance of water;

or 3% of dipropylene glycol, 5% of butanediol, 0.5% of xylitol, 0.05% of methyl glucitol polyether, 0.05% of trehalose, 1.5% of yeast extract, 0.15% of chitosan mono-succinamide, 0.1% of carbomer, 0.03% of potassium hydroxide, 0.3% of phenoxyethanol, 0.05% of sodium hyaluronate and the balance of water;

or 3% of dipropylene glycol, 5% of butanediol, 0.5% of xylitol, 0.05% of methyl glucitol polyether, 0.05% of trehalose, 3% of yeast extract, 0.3% of chitosan mono-succinamide, 0.1% of carbomer, 0.03% of potassium hydroxide, 0.3% of phenoxyethanol, 0.05% of sodium hyaluronate and the balance of water.