CN110115693A - A kind of supermolecule peptide composition and preparation method thereof for anti-ageing anti-wrinkle - Google Patents
A kind of supermolecule peptide composition and preparation method thereof for anti-ageing anti-wrinkle Download PDFInfo
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- CN110115693A CN110115693A CN201910428224.5A CN201910428224A CN110115693A CN 110115693 A CN110115693 A CN 110115693A CN 201910428224 A CN201910428224 A CN 201910428224A CN 110115693 A CN110115693 A CN 110115693A
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- ageing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention provides a kind of supermolecule peptide composition and preparation method thereof for anti-ageing anti-wrinkle, and ingredient includes: supermolecule polypeptide, pH adjusting agent, moisturizer, preservative, thickener, the emulsifier, deionized water of anti-ageing anti-wrinkle effect；Specific formula is made of the raw material of following component ratio: the supermolecule polypeptide 0.1 ~ 3% of anti-ageing anti-wrinkle effect, pH adjusting agent 0.5 ~ 3%, moisturizer 1 ~ 10%, preservative 0.5 ~ 3%, thickener 1 ~ 5%, emulsifier 0.1 ~ 2%, deionized water surplus.The present invention can be inhibited tyrosinase activity effectively using the supermolecule polypeptide of anti-ageing anti-wrinkle effect, reduce the generation and transfer of dermal melanin, while the formation for improving skin elasticity, reducing wrinkle；The simple process of processing method, it is easy to accomplish industrialized production.
Description
Technical field
It is specially a kind of for the supermolecule peptide composition of anti-ageing anti-wrinkle and its preparation the present invention relates to cosmetic field
Method.
Background technique
Skin aging be it is a kind of continue progressive physiology course, other than being influenced by objective factors such as age, heredity, also by
The many factors such as daylight, environment, health influence.The free radical wherein generated during organism metabolism is the underlying of skin aging
Factor, free radical have the chemical activity of height, can lead to lipid and carbohydrate oxidation, protein denaturation, enzyme inactivation etc., and then lure
Send out disease, skin aging etc. various.It is lived in seriously polluted environment for a long time or excessive contact is to the harmful chemicals of skin
Matter can all make premature skin ageing.
At present, it has been suggested that many compositions and method are used to preventing or treating aging effect, however, at present on the market
Product still can not meet the needs of people comprehensively.Supermolecule polypeptide, which refers to, to be had benifit to the vital movement of living organism or has
The active a kind of polypeptide aggregate of special physiological, this polypeptide aggregate can be realized the slow controlled release effect of polypeptide, greatly improve
The effective rate of utilization of polypeptide.But there is no about the production with good anti-aging performance using supermolecule polypeptide at present
Product are released.
Summary of the invention
Technical problem solved by the invention be to provide a kind of supermolecule peptide composition for anti-ageing anti-wrinkle and its
Preparation method, to solve the problems in above-mentioned background technique.
Technical problem solved by the invention is realized using following technical scheme: a kind of supermolecule for anti-ageing anti-wrinkle
Peptide composition, ingredient include: the supermolecule polypeptide of anti-ageing anti-wrinkle effect, pH adjusting agent, moisturizer, preservative, thickener,
Emulsifier, deionized water；Specific formula is made of the raw material of following component ratio: the supermolecule polypeptide 0.1 of anti-ageing anti-wrinkle effect~
3%, pH adjusting agent 0.5~3%, moisturizer 1~10%, preservative 0.5~3%, thickener 1~5%, emulsifier 0.1~
2%, deionized water surplus.
Further, the supermolecule polypeptide of described anti-ageing anti-wrinkle effect includes that behenic acid--7 bi-component of palmityl tetrapeptide is super
Molecular peptide, -4 bi-component supermolecule peptide of behenic acid-Matrixyl, -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide, mountain
- 1 bi-component supermolecule peptide of Yu acid-palmityl tripeptides, -5 bi-component supermolecule peptide of stearic acid-acetyl group tetrapeptide, arachidic acid-class snake
Phallotoxins bi-component supermolecule peptide, -1 bi-component supermolecule peptide of arachidic acid-nonapeptide, in arachidic acid-carnosine bi-component supermolecule peptide
It is at least one.
Further, the pH adjusting agent includes at least one of triethanolamine, sodium citrate.
Further, the moisturizer includes at least one of glycerol, butanediol.
Further, the preservative includes at least one of Phenoxyethanol, Sensiva SC50.
Further, the thickener includes at least one of xanthan gum, sodium alginate.
Further, the emulsifier includes at least one of polysorbate -20, Polyoxyethylene Sorbitan Monooleate.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, the supermolecule polypeptide of anti-ageing anti-wrinkle effect is sequentially added, is stirred evenly；
Step 2 will sequentially add thickener, emulsifier in the above-mentioned mixed liquor stirred evenly, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add moisturizer, preservative, and stirring is equal
It is even；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Be compared to open technology, there are following advantages by the present invention: the present invention is more using the supermolecule of anti-ageing anti-wrinkle effect
Peptide can be inhibited tyrosinase activity effectively, reduce the generation and transfer of dermal melanin, while being improved skin elasticity, being reduced wrinkle
The formation of line；The supermolecule peptide composition of offer can promote epidermis reparation and regeneration, molecular structure and fell skin tissue
Corresponding Porcine HGF is very close, can make to the physiology such as skin histology and its corresponding promoting growth of cell of cells play
With can effectively improve dark yellow skin, bright color, while delaying skin aging；The simple process of the method is easy to real
Existing industrialized production.
Specific embodiment
In order to make, technological means of the invention, creation characteristic, workflow, application method reach purpose and effect is easy to bright
White understanding, below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle, ingredient include: that the supermolecule of anti-ageing anti-wrinkle effect is more
Peptide, pH adjusting agent, moisturizer, preservative, thickener, emulsifier, deionized water；Specific formula by following component ratio raw material system
At: supermolecule polypeptide 0.1%, pH adjusting agent 0.5%, moisturizer 1%, the preservative 0.5%, thickener of anti-ageing anti-wrinkle effect
1%, emulsifier 0.1%, deionized water surplus.
Further, the supermolecule polypeptide of described anti-ageing anti-wrinkle effect includes that behenic acid--7 bi-component of palmityl tetrapeptide is super
Molecular peptide, -4 bi-component supermolecule peptide of behenic acid-Matrixyl, -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide, mountain
- 1 bi-component supermolecule peptide of Yu acid-palmityl tripeptides, -5 bi-component supermolecule peptide of stearic acid-acetyl group tetrapeptide, arachidic acid-class snake
Phallotoxins bi-component supermolecule peptide, -1 bi-component supermolecule peptide of arachidic acid-nonapeptide, in arachidic acid-carnosine bi-component supermolecule peptide
It is at least one.
Further, the pH adjusting agent includes at least one of triethanolamine, sodium citrate.
Further, the moisturizer includes at least one of glycerol, butanediol.
Further, the preservative includes at least one of Phenoxyethanol, Sensiva SC50.
Further, the thickener includes at least one of xanthan gum, sodium alginate.
Further, the emulsifier includes at least one of polysorbate -20, Polyoxyethylene Sorbitan Monooleate.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, the supermolecule polypeptide of anti-ageing anti-wrinkle effect is sequentially added, is stirred evenly；
Step 2 will sequentially add thickener, emulsifier in the above-mentioned mixed liquor stirred evenly, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add moisturizer, preservative, and stirring is equal
It is even；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Embodiment 2
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle, ingredient include: that the supermolecule of anti-ageing anti-wrinkle effect is more
Peptide, pH adjusting agent, moisturizer, preservative, thickener, emulsifier, deionized water；Specific formula by following component ratio raw material system
At: the supermolecule polypeptide 3%, pH adjusting agent 3%, moisturizer 10%, preservative 3%, thickener 5%, cream of anti-ageing anti-wrinkle effect
Agent 2%, deionized water surplus.
Further, the supermolecule polypeptide of described anti-ageing anti-wrinkle effect includes that behenic acid--7 bi-component of palmityl tetrapeptide is super
Molecular peptide, -4 bi-component supermolecule peptide of behenic acid-Matrixyl, -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide, mountain
- 1 bi-component supermolecule peptide of Yu acid-palmityl tripeptides, -5 bi-component supermolecule peptide of stearic acid-acetyl group tetrapeptide, arachidic acid-class snake
Phallotoxins bi-component supermolecule peptide, -1 bi-component supermolecule peptide of arachidic acid-nonapeptide, in arachidic acid-carnosine bi-component supermolecule peptide
It is at least one.
Further, the pH adjusting agent includes at least one of triethanolamine, sodium citrate.
Further, the moisturizer includes at least one of glycerol, butanediol.
Further, the preservative includes at least one of Phenoxyethanol, Sensiva SC50.
Further, the thickener includes at least one of xanthan gum, sodium alginate.
Further, the emulsifier includes at least one of polysorbate -20, Polyoxyethylene Sorbitan Monooleate.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, the supermolecule polypeptide of anti-ageing anti-wrinkle effect is sequentially added, is stirred evenly；
Step 2 will sequentially add thickener, emulsifier in the above-mentioned mixed liquor stirred evenly, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add moisturizer, preservative, and stirring is equal
It is even；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Embodiment 3
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 7 bi-component supermolecule peptide 0.1% of behenic acid-palmityl tetrapeptide, -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide
0.1%, glycerol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan gum 0.5%, polysorbate -20 0.3%, go from
Sub- water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, sequentially add -7 bi-component supermolecule peptide of behenic acid-palmityl tetrapeptide, stearic acid--8 bi-component supermolecule of second phthalidyl hexapeptide
Peptide stirs evenly；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly xanthan gum, polysorbate -20, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Comparative example 3
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 8 bi-component supermolecule peptide 0.1% of stearic acid-second phthalidyl hexapeptide, glycerol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan
Glue 0.5%, polysorbate -20 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide is sequentially added, is stirred evenly；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly xanthan gum, polysorbate -20, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Embodiment 4
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 4 bi-component supermolecule peptide 0.1% of behenic acid-Matrixyl, -5 bi-component supermolecule peptide of stearic acid-acetyl group tetrapeptide
0.1%, glycerol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan gum 0.5%, polysorbate -20 0.3%, go from
Sub- water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, sequentially add -4 bi-component supermolecule peptide of behenic acid-Matrixyl, -5 bi-component supermolecule of stearic acid-acetyl group tetrapeptide
Peptide stirs evenly；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly xanthan gum, polysorbate -20, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Store
Comparative example 4
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 5 bi-component supermolecule peptide 0.1% of stearic acid-acetyl group tetrapeptide, glycerol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan
Glue 0.5%, polysorbate -20 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, -5 bi-component supermolecule peptide of stearic acid-acetyl group tetrapeptide is sequentially added, is stirred evenly；
Step 2 will sequentially add xanthan gum, polysorbate -20 in the above-mentioned mixed liquor stirred evenly, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Embodiment 5
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
It is -1 bi-component supermolecule peptide 0.1% of behenic acid-palmityl tripeptides, arachidic acid-class snake venom peptide bi-component supermolecule peptide 0.1%, sweet
Oil 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan gum 0.5%, polysorbate -20 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, -1 bi-component supermolecule peptide of behenic acid-palmityl tripeptides, arachidic acid-class snake venom peptide bi-component supermolecule peptide are sequentially added, is stirred
It mixes uniformly；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly xanthan gum, polysorbate -20, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Comparative example 5
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
Arachidic acid-class snake venom peptide bi-component supermolecule peptide 0.1%, glycerol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan gum
0.5%, polysorbate -20 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, arachidic acid-class snake venom peptide bi-component supermolecule peptide is sequentially added, is stirred evenly；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly xanthan gum, polysorbate -20, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Embodiment 6
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 7 bi-component supermolecule peptide 0.1% of behenic acid-palmityl tetrapeptide, arachidic acid-carnosine bi-component supermolecule peptide 0.1%, glycerol
6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan gum 0.5%, polysorbate -20 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, -7 bi-component supermolecule peptide of behenic acid-palmityl tetrapeptide, arachidic acid-carnosine bi-component supermolecule peptide are sequentially added, stirring is equal
It is even；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly xanthan gum, polysorbate -20, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Comparative example 6
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 7 bi-component supermolecule peptide 0.1% of behenic acid-palmityl tetrapeptide, glycerol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, xanthan
Glue 0.5%, polysorbate -20 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, -7 bi-component supermolecule peptide of behenic acid-palmityl tetrapeptide is sequentially added, is stirred evenly；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly xanthan gum, polysorbate -20, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add glycerol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Embodiment 7
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 4 bi-component supermolecule peptide 0.1% of behenic acid-Matrixyl, -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide
0.1%, butanediol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, sodium alginate 0.5%, polysorbate -60 0.3%,
Deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, sequentially add -4 bi-component supermolecule peptide of behenic acid-Matrixyl, stearic acid--8 bi-component supermolecule of second phthalidyl hexapeptide
Peptide stirs evenly
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly sodium alginate, polysorbate -60, stirring is equal
It is even
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add butanediol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Store
Comparative example 7
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 4 bi-component supermolecule peptide 0.1% of behenic acid-Matrixyl, butanediol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, sea
Mosanom 0.5%, polysorbate -60 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps: step 1, general
Deionized water is put into reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80 DEG C, is sequentially added behenyl
- 4 bi-component supermolecule peptide of acid-Matrixyl, stirs evenly；
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly sodium alginate, polysorbate -60, stirring is equal
It is even；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add butanediol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Embodiment 8
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 1 bi-component supermolecule peptide 0.1% of behenic acid-palmityl tripeptides, arachidic acid-class snake venom peptide bi-component supermolecule peptide 0.1%, fourth
Glycol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, sodium alginate 0.5%, polysorbate -60 0.3%, deionized water
Surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, -1 bi-component supermolecule peptide of behenic acid-palmityl tripeptides, arachidic acid-class snake venom peptide bi-component supermolecule peptide are sequentially added, is stirred
Mix uniform
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly sodium alginate, polysorbate -60, stirring is equal
It is even
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add butanediol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Store
Comparative example 8
A kind of supermolecule peptide composition for anti-ageing anti-wrinkle is mainly prepared from the following raw materials in terms of ingredient accounting:
- 1 bi-component supermolecule peptide 0.1% of behenic acid-palmityl tripeptides, butanediol 6%, hyaluronic acid 3%, Phenoxyethanol 0.3%, sea
Mosanom 0.5%, polysorbate -60 0.3%, deionized water surplus.
A kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, specifically includes the following steps:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80
DEG C, -1 bi-component supermolecule peptide of behenic acid-palmityl tripeptides is sequentially added, is stirred evenly
Step 2, will be sequentially added in the above-mentioned mixed liquor stirred evenly sodium alginate, polysorbate -60, stirring is equal
It is even
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add butanediol, hyaluronic acid, benzene oxygen second
Alcohol stirs evenly
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and at -10~-5 DEG C
Storage.
Anti-ageing experiment
(1) radicals scavenging is tested
Free radical is the intermediate product of biochemical reaction during vital movement, can result in skin aging.Utilize this
Invention supermolecule peptide composition evaluates its anti-ageing effect to the function and effect of free radical.
The supermolecule peptide composition of Example 1-5 preparation is made with the solution that dehydrated alcohol prepares various concentration respectively
For prepare liquid (10 μ of μ g/mL~500 g/mL), DPPH is configured to the solution of 0.2mmol/L with dehydrated alcohol.Take respectively 2mL to
It surveys liquid to mix with the DPPA of 2mL, in 25 DEG C of standing 30min of room temperature, the system that measured respectively with ultra-violet and visible spectrophotometer exists
Absorbance A i, Aj, A0 at 517nm, every group of measurement are averaged three times, and the clearance rate of DPPH free radical is calculated with following formula:
Wherein, A0For the absorbance value of DPPH solution, AiThe absorbance of the prepare liquid of various concentration is added for DPPH solution
Value, AjFor the absorbance value of the prepare liquid of various concentration.
(2) the activity suppression experiment of tyrosinase monophenolase.
Using L-3,4 dihydroxyphenylalanine as substrate, supermolecule peptide composition is probed into the inhibiting effect of tyrosinase monophenolase.
The supermolecule peptide composition of Example 1-6 preparation, is dissolved separately in DMSO, slow with pH=6.8 phosphate
Fliud flushing is diluted to various concentration as prepare liquid；It is the solution of 50U/mL tyrosinase with phosphate buffered saline enzyme activity；
With the L-3,4 dihydroxyphenylalanine solution of phosphate buffered saline 6mg/mL and 0.5mg/mL, as substrate solution.In test tube, it sequentially adds
L-3,4 dihydroxyphenylalanine solution, prepare liquid, phosphate buffer add tyrosinase solution after 37 DEG C of water-bath 10min, in 37 DEG C of water
Bathe 30min.Above-mentioned gained mixed liquor is transferred in cuvette, measures the absorbance at 475nm respectively.Every group of measurement takes three times
Average value, and influence of the different prepare liquids to tyrosinase vigor is calculated with following formula:
Wherein, A0The absorbance value of live body system when for containing L-3,4 dihydroxyphenylalanine, tyrosinase, prepare liquid.A1It is more containing L-
Bar, tyrosinase when live body system absorbance value.
After the enzyme activity for calculating above-mentioned different solutions, the half inhibiting rate IC of different prepare liquids is calculated50。
(3) skin elasticity is tested
The skin elasticity parameter value R tested out with MPA580 skin elasticity instrument2It is the important indicator for characterizing skin aging, it can
The using effect of directly perceived characterization supermolecule peptide composition of the invention.
Radicals scavenging experimental result, the activity of tyrosinase monophenolase of 3-8 of the embodiment of the present invention and comparative example 3-8
Inhibition assay result and skin elasticity experimental result are recorded in table 1.
Table 1
From the experimental result of table 1 as can be seen, supermolecule peptide composition provided by the invention can effectively prevent skin
Skin aging.The comparison result of embodiment 3-5 and comparative example 3-5 is it is inferred that comparative example is lacking behenic acid-palmityl tetrapeptide -7
Bi-component supermolecule peptide, -4 bi-component supermolecule peptide of behenic acid-Matrixyl, -1 bi-component of behenic acid-palmityl tripeptides are super
In the case of the supermolecule polypeptide of the anti-ageing effect such as molecular peptide, the anti-ageing effect of supermolecule peptide composition is decreased obviously.
Although embodiment 6-8 and comparative example 6-8 comparison result are as can be seen, comparative example contains behenic acid-palmityl tetrapeptide-
7 bi-component supermolecule peptides, -4 bi-component supermolecule peptide of behenic acid-Matrixyl, -1 bi-component of behenic acid-palmityl tripeptides are super
The supermolecule polypeptide of the anti-ageing effect such as molecular peptide, but be free of -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide, peanut
The supermolecule polypeptide situation of the anti-wrinkle effects such as acid-class snake venom peptide bi-component supermolecule peptide, arachidic acid-carnosine bi-component supermolecule peptide
Under, anti-ageing effect is also declined, so as to judge, the anti-ageing effect supermolecule polypeptide of the present invention and anti-wrinkle effect supermolecule
The compounding of polypeptide produces excellent effect.
Can be realized after each substance is reasonably combined in the present invention it is anti-oxidant, remove free radical, melanin production inhibited to answer
It closes supermolecule peptide composition and can effectively eliminate free radical, improve skin elasticity, long-time service can make skin keep elasticity profit
Pool, desalination wrinkle, delay skin aging.Basic principles and main features of the invention and of the invention have been shown and described above
Advantage.It should be understood by those skilled in the art that the present invention is not limited to the above embodiments, in above embodiments and description
Description merely illustrates the principles of the invention, and without departing from the spirit and scope of the present invention, the present invention also has various
Changes and improvements, these changes and improvements all fall within the protetion scope of the claimed invention.Claimed range of the invention by
Appended claims and its equivalent thereof.
Claims (8)
1. a kind of supermolecule peptide composition for anti-ageing anti-wrinkle, it is characterised in that: its ingredient includes: anti-ageing anti-wrinkle effect
Supermolecule polypeptide, pH adjusting agent, moisturizer, preservative, thickener, emulsifier, deionized water；Specific formula by below at
Divide the raw material of ratio to be made: the supermolecule polypeptide 0.1 ~ 3% of anti-ageing anti-wrinkle effect, moisturizer 1 ~ 10%, is prevented at pH adjusting agent 0.5 ~ 3%
Rotten agent 0.5 ~ 3%, thickener 1 ~ 5%, emulsifier 0.1 ~ 2%, deionized water surplus.
2. a kind of supermolecule peptide composition for anti-ageing anti-wrinkle according to claim 1, it is characterised in that: described anti-
The supermolecule polypeptide of the anti-wrinkle that declines effect includes -7 bi-component supermolecule peptide of behenic acid-palmityl tetrapeptide, behenic acid-palmityl five
- 4 bi-component supermolecule peptide of peptide, -8 bi-component supermolecule peptide of stearic acid-second phthalidyl hexapeptide, the behenic acid-group of palmityl tripeptides -1 pair
Divide supermolecule peptide, -5 bi-component supermolecule peptide of stearic acid-acetyl group tetrapeptide, arachidic acid-class snake venom peptide bi-component supermolecule peptide, flower
At least one of raw -1 bi-component supermolecule peptide of acid-nonapeptide, arachidic acid-carnosine bi-component supermolecule peptide.
3. a kind of supermolecule peptide composition for anti-ageing anti-wrinkle according to claim 1, it is characterised in that: the pH
Regulator includes at least one of triethanolamine, sodium citrate.
4. a kind of supermolecule peptide composition for anti-ageing anti-wrinkle according to claim 1, it is characterised in that: the guarantor
Humectant includes at least one of glycerol, butanediol.
5. a kind of supermolecule peptide composition for anti-ageing anti-wrinkle according to claim 1, it is characterised in that: described anti-
Rotten agent includes at least one of Phenoxyethanol, Sensiva SC50.
6. a kind of supermolecule peptide composition for anti-ageing anti-wrinkle according to claim 1, it is characterised in that: the increasing
Thick dose includes at least one of xanthan gum, sodium alginate.
7. a kind of supermolecule peptide composition for anti-ageing anti-wrinkle according to claim 1, it is characterised in that: the cream
Agent includes at least one of polysorbate -20, Polyoxyethylene Sorbitan Monooleate.
8. a kind of supermolecule peptide composition preparation method for anti-ageing anti-wrinkle, it is characterised in that: the following steps are included:
Step 1 puts into deionized water in reaction vessel, and adjusting pH value with pH adjusting agent is 7-8, is heated to 70-80 DEG C, according to
The secondary supermolecule polypeptide that anti-ageing anti-wrinkle effect is added, stirs evenly；
Step 2 will sequentially add thickener, emulsifier in the above-mentioned mixed liquor stirred evenly, stir evenly；
Step 3, the mixed liquor for obtaining step 2 are cooled to 50-55 DEG C, sequentially add moisturizer, preservative, stir evenly；
Step 4, the mixed liquor for obtaining step 3 are cooled to 20-30 DEG C, sterilization treatment post package, and store up at -10 ~ -5 DEG C
It deposits.
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Application publication date: 20190813 |