CN113648239A - Oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having anti-wrinkle repairing effect - Google Patents
Oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having anti-wrinkle repairing effect Download PDFInfo
- Publication number
- CN113648239A CN113648239A CN202111022695.XA CN202111022695A CN113648239A CN 113648239 A CN113648239 A CN 113648239A CN 202111022695 A CN202111022695 A CN 202111022695A CN 113648239 A CN113648239 A CN 113648239A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- oligopeptide
- skin care
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having an anti-wrinkle repairing effect. The prepared polyprotein and oligopeptide-synthesized oligonucleotide skin care preparation with the anti-wrinkle repairing effect can effectively accelerate the growth of cells in the dermis layer through the compound configuration of multiple components, the skin care effect is particularly outstanding, arginine/lysine polypeptide, acetyl hexapeptide-8 and various oligopeptides have the function of eliminating wrinkles, the components are used independently, the effect is single and limited, the compounding of the three components can generate a certain synergistic effect, the multiple oligopeptides can remove various wrinkles, deep wrinkles and expression lines which are formed, the skin can be plump, smooth and elastic through the nutrition supply of the multiple protein components, the youthful skin is refreshed, the youthful vitality is kept young, the wrinkle removing effect is remarkably improved, a new multi-effect cosmetic is provided for consumers, and the preparation has a better popularization prospect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having the effect of repairing and resisting wrinkles.
Background
Along with the continuous development and progress of society, the living standard of people is continuously improved, people pay more and more attention to self health and daily maintenance, particularly in recent years, along with the continuous deepening and development of industrialization, the environment is gradually worsened, drugs are abused, and various electronic products are popularized and used, the influence of physical factors and chemical factors leads to the increase of free radicals of skin epidermal cells of people, the free radicals not only promote the formation of melanin to cause skin pigmentation, but also can destroy collagen, active substances and oxidized cells in normal cell membrane tissues to form small fine lines and wrinkles, and due to the increase of social pressure, factors such as fatigue and the like also aggravate the aging and wrinkling of the skin.
In order to combat various skin problems, a number of cosmetic and skin care products have been introduced on the market to protect and repair the skin, collagen being one of the commonly used raw materials, a structural protein of the extracellular matrix in which molecules are aggregated into supramolecular structures. The molecular weight is 300 ku. The most common structural feature of collagen is a triple helix structure, and collagen is the most abundant protein in animals and accounts for more than 30% of human bodies. It belongs to an insoluble fibrous protein, also a class of extracellular matrices. Collagen can be extracted from animals in different tissues and different types of collagen, which also have different functions and effects. The collagen extracted to be soluble is generally procollagen, and is called "bone in bone, skin in skin, meat in meat", which is a strong hind shield of the dermis layer, and its effect on the skin is self-evident. The collagen maintenance product is a comprehensive structural protein, can effectively accelerate the growth of dermal cells, activate epidermal cells, maintain the elasticity and firmness of skin, prevent wrinkles from appearing, enable the skin to be richer in elasticity and firmer, and present delicate, white and transparent skin, but the collagen has a single function and cannot effectively care and restore wrinkled skin, so that a compound preparation capable of preventing wrinkles, maintaining elasticity and removing wrinkles is needed.
Disclosure of Invention
In view of the problems in the prior art, the invention discloses an oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having the effect of repairing wrinkle resistance, which comprises the following main components in parts by weight:
as a preferred embodiment of the present invention, acetyl hexapeptide-8 is a neurotransmitter inhibitory peptide that participates in competing for SNAP-25 at the site of the vacuolar complex, thereby affecting complex formation. When the vesicular complex is slightly unstable, the vesicle can not effectively release neurotransmitter, so that the muscle contraction is weakened, the formation of wrinkles is prevented, and the anti-wrinkle activity is high and the side effect is small.
As a preferred scheme of the invention, the arginine/lysine polypeptide is a biological simulated conotoxin peptide, provides a very strong muscle relaxation effect through sequencing and artificial synthesis, provides a quick and instant anti-wrinkle effect, provides effective muscle relaxation but not complete stiff paralysis, and retains 5% of neuromuscular current conduction of muscles, so that a natural rejuvenation effect is provided, and the arginine/lysine polypeptide is a highly folded peptide, strongly penetrates, has high stability, and achieves the effect of relaxing the muscles in a targeted manner.
In a preferred embodiment of the present invention, Lactoferrin (LF) is an important non-heme iron-binding glycoprotein in milk, a monomeric glycoprotein with bactericidal activity in neutrophil granules. The molecular weight of the polypeptide is 80kDa, is mainly expressed and secreted by mammary epithelial cells, and has strong biological functions of broad-spectrum antibiosis, antioxidation, anticancer, immune system regulation and the like.
As a preferred embodiment of the present invention, the oligopeptide is a classification of polypeptides, the molecular weight segment is generally below 1000 Dalton, also called small peptide, oligopeptide or called small molecule active peptide, generally comprises 4-10 amino acids, and can be directly absorbed without digestion in human body, and is divided into oligopeptide-1, oligopeptide-3, oligopeptide-5 and hexapeptide.
In a preferred embodiment of the present invention, SODIUM HYALURONATE (SODIUM HYALURONATE) is a substance extracted from cockscomb, or can be prepared by fermentation of lactococcus lactis, is white or white-like granule or powder, has no odor, has nitrogen content of 2.8% -4.0% and glucuronic acid content of 37.0% -51.0% when dried, and can be used in cosmetic cream, honey, milk, facial mask, shampoo, etc. for maintaining moisture of skin and hair, moistening skin and hair, increasing luster, and preventing chapped skin and wrinkle.
As a preferred embodiment of the present invention, elastin is the main component of elastic fibers. Elastic fibers are found primarily in ligaments and vessel walls. The presence of elastic fibers in combination with collagen fibers imparts elasticity and tensile strength to the tissue.
The invention has the beneficial effects that: according to the multi-protein and oligopeptide-synthesized oligonucleotide skin care preparation with the anti-wrinkle repairing effect, which is prepared by compounding multiple components, collagen can effectively accelerate the growth of cells in the dermis layer, the skin care effect is particularly remarkable, arginine/lysine polypeptide, acetyl hexapeptide-8 and various oligopeptides have the function of eliminating wrinkles, the components are used independently, the effect is single and limited, the three components can generate a certain synergistic effect by compounding, the multiple oligopeptide components remove formed multiple wrinkles, deep wrinkles and expression lines, the skin achieves fullness, smoothness and elasticity by nutrition supply of the multiple protein components, the young skin and youthful vigor are refreshed, the wrinkle removing effect is remarkably improved, a new multi-effect cosmetic is provided for consumers, and the popularization prospect is good.
Detailed Description
Example 1
The invention relates to an oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having the anti-wrinkle repairing effect, which comprises the following main components in parts by weight:
example 2
The oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having the anti-wrinkle repairing effect, disclosed by the invention, preferably comprises the following main components in parts by weight:
example 3
The invention relates to an oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having the anti-wrinkle repairing effect, which comprises the following main components in parts by weight:
example 4
The invention relates to an oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having the anti-wrinkle repairing effect, which comprises the following main components in parts by weight:
the main components have the following functions:
acetyl hexapeptide-8 is a neurotransmitter inhibitory peptide, reduces muscle contraction, prevents wrinkle formation, and has high anti-wrinkle activity and low side effects.
The arginine/lysine polypeptide is biologically simulated conotoxin peptide, provides a very strong muscle relaxation effect through sequencing and artificial synthesis, provides a quick and instant anti-wrinkle effect, provides effective muscle relaxation but not complete stiff paralysis, and keeps 5% of neuromuscular current conduction of muscles, so that a natural rejuvenation effect is provided, and the arginine/lysine polypeptide is highly folded peptide, is strongly penetrated, has high stability, and achieves the relaxation effect on the muscles in a targeted manner.
The sodium hyaluronate is white or white-like granule or powder, has no odor, has nitrogen content of 2.8-4.0% and glucuronic acid content of 37.0-51.0% when being dried, and can be used in cosmetic products such as cream, honey, milk, facial mask, shampoo, etc., to keep moisture of skin and hair, moisten skin and hair, increase luster, and prevent chapped skin and wrinkle.
Elastin is the main component of elastic fibres. Elastic fibers are found primarily in ligaments and vessel walls. The presence of elastic fibers in combination with collagen fibers imparts elasticity and tensile strength to the tissue.
Parts not described in detail herein are prior art.
Although the present invention has been described in detail with reference to the specific embodiments, the present invention is not limited to the above embodiments, and various changes and modifications without inventive changes may be made within the knowledge of those skilled in the art without departing from the spirit of the present invention.
Claims (5)
1. An oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having the effect of repairing wrinkle resistance is characterized by comprising the following main components in parts by weight: 6-12 parts of glycerol, 10-20 parts of hydrolyzed elastin, 5-10 parts of fibronectin, 81-4 parts of acetyl hexapeptide, 2-8 parts of serum protein, 1-6 parts of lactoferrin, 6-15 parts of arginine/lysine polypeptide, 15-15 parts of oligopeptide-15, 35-15 parts of oligopeptide-15, 1-4 parts of bluecopper peptide, 4-10 parts of hexapeptide, 10-20 parts of sodium hyaluronate and 60 parts of water.
2. The skin care preparation of claim 1, wherein the skin care preparation comprises an oligonucleotide synthesized from polyprotein and oligopeptide with anti-wrinkle effect: the collagen peptide is prepared from 6 parts by weight of glycerol, 10 parts by weight of hydrolyzed elastin, 5 parts by weight of fibronectin, 81 parts by weight of acetyl hexapeptide, 2 parts by weight of serum protein, 1 part by weight of lactoferrin, 6 parts by weight of arginine/lysine polypeptide, 15 parts by weight of oligopeptide, 35 parts by weight of oligopeptide, 1 part by weight of copper-containing peptide, 4 parts by weight of hexapeptide, 10 parts by weight of sodium hyaluronate and 60 parts by weight of water.
3. The skin care preparation of claim 1, wherein the skin care preparation comprises an oligonucleotide synthesized from polyprotein and oligopeptide with anti-wrinkle effect: the collagen peptide is prepared from 12 parts by weight of glycerol, 20 parts by weight of hydrolyzed elastin, 10 parts by weight of fibronectin, 84 parts by weight of acetyl hexapeptide, 8 parts by weight of serum protein, 6 parts by weight of lactoferrin, 15 parts by weight of arginine/lysine polypeptide, 115 parts by weight of oligopeptide, 315 parts by weight of oligopeptide, 4 parts by weight of copper-coated peptide, 10 parts by weight of hexapeptide, 20 parts by weight of sodium hyaluronate and 60 parts by weight of water.
4. The skin care preparation of claim 1, wherein the skin care preparation comprises an oligonucleotide synthesized from polyprotein and oligopeptide with anti-wrinkle effect: the collagen peptide is prepared from 8 parts by weight of glycerol, 15 parts by weight of hydrolyzed elastin, 9 parts by weight of fibronectin, 82 parts by weight of acetyl hexapeptide, 6 parts by weight of serum protein, 2 parts by weight of lactoferrin, 8 parts by weight of arginine/lysine polypeptide, 110 parts by weight of oligopeptide, 310 parts by weight of oligopeptide, 2 parts by weight of copper-coated peptide, 6 parts by weight of hexapeptide, 13 parts by weight of sodium hyaluronate and 60 parts by weight of water.
5. The skin care preparation of claim 1, wherein the skin care preparation comprises an oligonucleotide synthesized from polyprotein and oligopeptide with anti-wrinkle effect: the composition is prepared from 11 parts by weight of glycerol, 17 parts by weight of hydrolyzed elastin, 7 parts by weight of fibronectin, 83 parts by weight of acetyl hexapeptide, 5 parts by weight of serum protein, 5 parts by weight of lactoferrin, 12 parts by weight of arginine/lysine polypeptide, 112 parts by weight of oligopeptide, 312 parts by weight of oligopeptide, 3 parts by weight of copper-containing peptide, 8 parts by weight of hexapeptide, 18 parts by weight of sodium hyaluronate and 60 parts by weight of water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111022695.XA CN113648239A (en) | 2021-09-01 | 2021-09-01 | Oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having anti-wrinkle repairing effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111022695.XA CN113648239A (en) | 2021-09-01 | 2021-09-01 | Oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having anti-wrinkle repairing effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113648239A true CN113648239A (en) | 2021-11-16 |
Family
ID=78493407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111022695.XA Withdrawn CN113648239A (en) | 2021-09-01 | 2021-09-01 | Oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having anti-wrinkle repairing effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113648239A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652635A (en) * | 2022-03-07 | 2022-06-24 | 广州市万千粉丝化妆品有限公司 | Lactose protein component applied to cosmetics and preparation method |
| CN114652666A (en) * | 2022-04-14 | 2022-06-24 | 广州市万千粉丝化妆品有限公司 | Application preparation of nourishing and nourishing intelligence-improving components in skin care and care products |
| CN115634169A (en) * | 2022-04-27 | 2023-01-24 | 广州市万千粉丝化妆品有限公司 | Application of extracellular matrix beta-myoglycan protein in cosmetics for repairing hormone-dependent skin |
-
2021
- 2021-09-01 CN CN202111022695.XA patent/CN113648239A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652635A (en) * | 2022-03-07 | 2022-06-24 | 广州市万千粉丝化妆品有限公司 | Lactose protein component applied to cosmetics and preparation method |
| CN114652666A (en) * | 2022-04-14 | 2022-06-24 | 广州市万千粉丝化妆品有限公司 | Application preparation of nourishing and nourishing intelligence-improving components in skin care and care products |
| CN115634169A (en) * | 2022-04-27 | 2023-01-24 | 广州市万千粉丝化妆品有限公司 | Application of extracellular matrix beta-myoglycan protein in cosmetics for repairing hormone-dependent skin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113648239A (en) | Oligonucleotide skin care preparation synthesized by polyprotein and oligopeptide and having anti-wrinkle repairing effect | |
| US6620419B1 (en) | Cosmetic or dermopharmaceutical use of peptides for healing, hydrating and improving skin appearance during natural or induced ageing (heliodermia, pollution) | |
| CN102178636B (en) | Marine biological function cosmetic for minimizing pores | |
| CN101878019B (en) | Personal care and cosmetic composition containing tetrapeptides with the motifs gx1x2g, px1x2p, or px1x2k | |
| KR100858575B1 (en) | External skin preparations and process for producing the same | |
| CN108852894A (en) | It is a kind of for repairing the polypeptides in combination of whitening wrinkle-removing | |
| KR100862979B1 (en) | Composition of Collagen Peptides for Cosmetics and Method Thereof | |
| WO2015083630A1 (en) | Composition comprising collagen peptide, elastin peptide and proteoglycan | |
| CN105640862A (en) | Skin beautifying cosmetic for whitening, moisture preserving, anti-wrinkling and pore shrinking | |
| CN103948525B (en) | Anti-aging active composition for epidermis | |
| CN104414914A (en) | Striae gravidarum recovery essence | |
| WO2024149215A1 (en) | Designed peptide, and composition and use thereof | |
| JP2000201649A (en) | Dermal metabolism accelerator and functional food | |
| CN116143873A (en) | Active peptide and application thereof in preparation of anti-skin-aging drugs or cosmetics | |
| CN102988193A (en) | Medical beautifying polypeptide capable of promoting cell regeneration and delaying skin aging | |
| CN108524354A (en) | Skin care compositions, facial treatment mask and preparation method thereof | |
| JP2008100943A (en) | External preparation for skin having action to promote secretion of insulin-like growth factor 1 | |
| WO2016133775A1 (en) | Collagen-boosting compositions and methods | |
| CN109730943A (en) | A kind of anti-wrinkle composition | |
| CN110585079A (en) | Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof | |
| CN115444771A (en) | Micromolecular peptide stock solution and preparation method thereof | |
| CN114652666A (en) | Application preparation of nourishing and nourishing intelligence-improving components in skin care and care products | |
| CN109528546A (en) | Has effects that crease-resistant cosmetic composition and preparation method thereof | |
| KR101997231B1 (en) | Cosmetic composition containing enzyme-treated honey extract | |
| CN116685307A (en) | Cosmetic, nutritional or dermatological use of lactobacillus crispatus strains and/or compositions comprising the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20211116 |
|
| WW01 | Invention patent application withdrawn after publication |