CN102178636B - Marine biological function cosmetic for minimizing pores - Google Patents
Marine biological function cosmetic for minimizing pores Download PDFInfo
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- CN102178636B CN102178636B CN201110106633A CN201110106633A CN102178636B CN 102178636 B CN102178636 B CN 102178636B CN 201110106633 A CN201110106633 A CN 201110106633A CN 201110106633 A CN201110106633 A CN 201110106633A CN 102178636 B CN102178636 B CN 102178636B
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Abstract
The invention discloses marine biological function cosmetics for minimizing pores. The marine biological function cosmetics for minimizing the pores are prepared by mixing and homogenizing main active ingredients and a cosmetic substrate, wherein the main active ingredients comprise marine shellfish active peptide, marine collagen protein peptide, seaweed polysaccharide and fish oil. Hyaluronic acid and vitamin C (Vc) are added, so that the effect is more obvious. The marine biological function cosmetics for minimizing the pores solve the problems that the conventional cosmetics for minimizing the pores have high irritation and short action time, the marine shellfish active peptide is not applied to cosmetics, the marine biological active substances are not applied to the cosmetics for minimizing the pores and the like. The marine biological function cosmetics for minimizing the pores are safe, mild, high-efficiency and durable, can minimize the pores from inside to outside, recover fineness, softness and smoothness, and enable skin to give out natural, clean and transparent gloss. The marine biological function cosmetics for minimizing the pores have various types, such as cream, emulsion, water agent, gel, spray or masks, have obvious and durable pore-minimizing effect and can serve as the common skin-care products or the cosmetics with the function of minimizing the pores. After the marine biological function cosmetics are not used, the pore bulky symptom is not rebounded.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of function cosmetics that are used for careful pore, relating in particular to a kind of is the marine organisms function cosmetics that are used for careful pore of main active preparation with the marine organism extract.
Background technology
Along with the development of society, the progress of medical science, the improvement of quality of life, people begin to pursue the life of quality, and the attention degree careful to facial skin especially pore also significantly improves.Because influence of various factors such as age, endocrine, the pore regular meeting of facial skin becomes comparatively thick.Thick pore has not only stayed the years vestige that is difficult to wear away, and badly influences the attractive in appearance of skin, and this becomes personage's puzzlement a great problem for a long time of liking to be beautiful.In recent years, careful skin pore series products just enjoys liking of consumer once release.
At present, mostly on the market careful skin pore series products is the Theory of Convergence Classes astringent, chamfers bolt class and exfoliation class cosmetics etc.Mostly the Theory of Convergence Classes astringent is to utilize alcohol that skin surface temperature is temporarily descended; Or utilize organic acid such as citric acid to make protein coagulating; Played the effect of temporarily tightening up skin and pore, but big, also can't fundamentally solve the problem of corse sweat pore the load and the zest of skin.Mostly the bolt class cosmetics of chamfering are the keratotic plug that is blocked in the pore is carried out physical removal, but keratotic plug can regenerate again very soon, if deal with improperly, it is bigger that pore can become.Therefore, chamfering bolt class cosmetics damages easily skin or side effect is arranged.And exfoliation class cosmetics contain salicylic acid etc. more, though can soften sclerderm, dissolving cutin, remove the dead bark that is deposited in skin surface, and the pore that mediation is stopped up is very big to the zest of skin, also is prone to damage to sensitive skin.
And the marine bioactivity extract is because of himself good biocompatibility, and conclusive moistening water conservation effect and clear and definite biological activity have received scientific research personnel's the attention and the favor on beauty treatment circle.Marine bioactivity materials such as collagen peptide, Sargassum polysaccharides, chitosan, oligonucleotide, chondroitin sulfate, carotenoid, squalane, deep-sea enzyme successfully are developed to all kinds of cosmetics at present, but the marine organisms function cosmetics that are used for careful pore still belong to blank.In addition, as the seashells of one of most precious living marine resources, its bioactive peptide also has effects such as slow down aging, resisting fatigue, radioprotective, but also is not applied in the cosmetics as yet.At present, though existing patent of invention discloses the method for preparing of seashells anti-oxidation peptide, and points out that it can be used for cosmetics, unactual technique for applying technology and prescription do not relate to yet it are mixed with the function cosmetics that are used for careful pore.
Summary of the invention
The objective of the invention is to problems such as big to careful pore class cosmetics zest, that the efficacy effect time is short, the seashells bioactive peptide is not used as yet, the marine bioactivity material is not used as yet in cosmetics, a kind of safe, gentle, efficient, persistent marine organisms function cosmetics that are used for careful pore are provided in careful pore class cosmetics.The careful pore functional component of these marine organisms function cosmetics is clear and definite, steady quality, numerous in variety; Can play more remarkable, magical careful pore effect from inside to outside; And have no side effect, can not cause skin allergy, the back corse sweat pore symptom of stopping using does not rebound yet.
Forming marine organisms function cosmetics main active of the present invention is seashells bioactive peptide, marine collagen protein peptide, Sargassum polysaccharides and fish oil, and its weight content is seashells bioactive peptide 0.1%-10%, marine collagen protein peptide 0.1%-15%, Sargassum polysaccharides 0.5%-8%, fish oil 0.2%-10%.The preferred weight content of forming marine organisms function cosmetics main active of the present invention is: seashells bioactive peptide 0.5%-10%, marine collagen protein peptide 1%-10%, Sargassum polysaccharides 1%-5%, fish oil 0.5%-6%.For strengthening the effect of careful pore, the active component of forming marine organisms function cosmetics of the present invention also can comprise hyaluronic acid 0.1%-4% and V
C1%-10%.
In the above-mentioned active component, described seashells bioactive peptide is meant the seashells bioactive peptide mixture that makes after ocean shellfish meat is through protease hydrolyzed, the ultrafiltration of 3000Da ultrafilter membrane; Said seashells is meant one or more the combination in Paphia Undulata, Corbiculida, Margarita, scallop, mussel, the Concha Ostreae; Said protease is one or more the combination in bromelain, papain, neutral protease, alkaline protease, pepsin, trypsin, the subtilisin.Specifically the method for preparing of seashells bioactive peptide is following: get the edible seashells that meets China's relevant marine product use standard, add 2-4 times of volume pure water homogenate 3-5min behind the internal organs that shell, room temperature adds protease; Enzyme concentration is a 1000-3000U/g shellfish meat; At pH is 6.5-7.5, and temperature is 40-60 ℃, enzymolysis 30-90min; Boiling water bath enzyme denaturing 5-8min; The centrifugal 10-15min of 5000-8000r/m, supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, lyophilization makes the seashells active peptide powder.
In the above-mentioned active component; Described marine collagen protein peptide is meant cod collagen peptide, sharkskin collagen peptide, shark cartilage collagen protein peptide, holothurian collagen peptide or collagen from squid skin peptide; Can prepare according to methods such as existing protease hydrolyzeds, also commercially available.Described Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide, the Hijiki polysaccharide; Commercially available, also can be according to existing method preparation.Said fish oil is meant bathypelagic fish oil, and said bathypelagic fish is one or more the combination in shark, salmon, morrhua, sardine, salmon fish, rainbow trout, Microcanthus strigatus, the mackerel, and is commercially available, also can be according to existing method preparation.Said hyaluronic acid, V
CBe commercial with the cosmetic base component.
Above-mentioned active component carries out homogenizing through common process with the cosmetic base component or mixes, and promptly can be made into cream frost, emulsion, water preparation, gel, spraying or facial film.Cosmetics exquisite quality among the present invention, glossy, good stability, coating is even, spreadability is good.
Through zoopery and human body proof test; Find that marine bioactivity material contained in the cosmetics of the present invention all can be absorbed rapidly by skin; And play the effect of more significant, magical careful pore from inside to outside, make the pore of expansion be contracted to very little.In short 4 weeks, it is real fine and smooth soft and smooth that skin can recover, and give out the brilliance that nature passes through only.In addition, the cosmetics among the present invention do not have toxic and side effects, can not cause skin allergy yet.
Not only molecular weight is little, good water solubility for seashells bioactive peptide in the marine organisms function cosmetics of the present invention, can infiltrate skin surface rapidly, and has the effect of remarkable removing free radical, can effectively resist skin by keratinization, keeps youthful vigor.It can also promote elastic fibers, collagen protein synthesis in the skin corium and the wound healing that is caused by inflammation, acne, makes skin recover tension force and elasticity, and strengthens the support force of hair follicle in the skin, makes shrinking pore, and skin more compacts.In addition, the seashells bioactive peptide can also significantly reduce the activity of tryrosinase, forms thereby suppress melanin, makes skin become pale, and pore is not obvious.
In seashells bioactive peptide mixture, also contain abundant free amino acid, V
A, V
B, V
E, Zn and Se etc., these active component all can careful effectively pore.Serine, glycine, threonine and alanine are NMFs natural in the horny layer, and methionine and cysteine are keratin important composition compositions, and glycine, proline and alanine are collagen protein important composition compositions.Arginine can promote skin metabolism and the wound healing that is caused by inflammation, acne.Glutamic acid can promote cell proliferation and differentiation, and promotes collagen protein to generate.Ornithine can promote cell proliferation and aging skin regeneration.Methionine, histidine, glutamic acid and cysteine can protect skin because of the ultraviolet radiation corse sweat pore, and can suppress the melanin generation.V
ACan improve skin natural cover for defense function and elasticity, epidermis is thickened, delay the cell keratinization.V
BThe scalable fat secretion, promote skin oil-water balance, alleviate pore and drain the oils and fats burden.V
ECan increase horny layer humidity, improve the skin smooth degree, strengthen the resistance of skin to uv damage, protection skin is avoided oxidative damage.Zn is an indispensable composition in the superoxide dismutase, can promote skin metabolism, reduces pigmentation.Se is the active center of glutathion peroxidase, can resist UV-induced corse sweat pore, the corse sweat pore that acne and dermatitis are caused to improve effect very obvious.
Marine collagen albumen Toplink in the marine organisms function cosmetics of the present invention significantly strengthens cell viability and skin is glossy, and it is moistening to keep skin surface, and the youth that represents skin is beautiful.Owing to contain hydrophilic groups such as abundant hydroxyl, amino, the marine collagen protein peptide has good moisture preserving property.The affinity of itself and skin surrounding tissue is good; Can promote SF collagen and hyaluronic generation; The metabolism of repairing skin tissue, promotion skin; And improve skin elasticity, thereby realize skin care, softening sclerderm, promote the purpose that skin is newborn, slow down skin keratinization, careful pore.
Hydroxyl, carboxyl isopolarity group in the Sargassum polysaccharides molecule in the marine organisms function cosmetics of the present invention all can form hydrogen bond with hydrone, and also being interweaved between glycan molecule reticulates.In extracellular matrix, the common outer gelatinised matrix of the born of the same parents that contain large quantity of moisture of forming of other polysaccharide components in itself and the skin and fibrous proteins is for skin provides moisture.Polysaccharide also can form the layer of even thin film at skin surface, to reduce the skin surface water evaporates, makes moisture permeate into horny layer from the substrate tissue, induces the further aquation of horny layer, thereby preserves moisture of skin.Simultaneously, Sargassum polysaccharides also can promote the growth of horn cell and SF, thereby has the effect of good moisture preserving, softening sclerderm, careful pore.In addition; Research finds that also Sargassum polysaccharides can remove free radical, and obvious antioxidation activity is arranged, and can keep the activity of biochemical substances such as epidermal growth factor, SOD; Prevent that effectively ultraviolet and ionizing radiation from causing corse sweat pore, and can promote the renewal and the reparation of sunburn skin.
Fish oil in the marine organisms function cosmetics of the present invention contains abundant DHA and EPA.DHA and EPA are the main composition compositions of omega-fatty acid, but also are that human body self can not synthesize essential important component.These omega-fatty acids can reduce the percutaneous moisture loss; Increase skin hydration effect and wetting action; Keep skin oil-water balance, and can strengthen the recovery of skin barrier function, keep the barrier homeostasis; Make skin keep optimum membrane structure and function, and make skin become delicate, soft, flexible, smooth.Fish oil can also increase the output of antiinflammatory and antiproliferative eicosanoid, reduces by UV-induced inflammation, erythema and corse sweat pore.In addition, fish oil can also make cutaneous permeability increase, and the Skin Cell keratinization process that can slow down.
In marine organisms function cosmetics of the present invention, also can add hyaluronic acid and V
CHyaluronic acid is the important composition composition in skin and other tissue, and exogenous interpolation hyaluronic acid can replenish skin endogenous hyaluronic acid.The hyaluronic acid porous of small-molecular weight is to dermal layer of the skin; Keep moisture of skin; Promote epidermis cell increment, differentiation and wound healing; And can promote the supply and the waste discharge of seashells bioactive peptide, marine collagen protein peptide and Sargassum polysaccharides, keep pore unobstructed, lighten the load, prevent corse sweat pore.Hyaluronic acid also can form thin film on the surface, makes skin produce good smooth and moist feeling.V
CThrough the antioxidant activity of self, can suppress melanin and form, and suppress the activity of peroxidase, direct vat black pigment also, thus desalinate the mottle on the pore, make skin become pale, pore is not obvious.
Solution of the present invention is based on the various factors and formation mechanism of inventor to influencing corse sweat pore; And to the understanding of the beauty and skin care effect of marine bioactivity material; In conjunction with modern cosmetics and pharmacological research achievement; From numerous marine bioactivity extracts, filter out raw material, and carry out scientific composition, make it give full play to effect separately with careful pore effect.The active Toplink of seashells promotes elastic fibers and collagen protein synthesis in the skin corium, and can promote the wound surface skin that is caused by acne, acne, dermatitis to heal rapidly, makes skin recover tension force and elasticity, strengthens the hair follicle support force, careful pore; The skin care of marine collagen albumen Toplink promotes SF collagen and hyaluronic acid to generate, and repairing skin tissue makes the skin of sagging thick pore recover elasticity; Sargassum polysaccharides has extremely strong moisture-keeping function, can resist ultraviolet and ionizing radiation causes corse sweat pore, and can promote sunburn skin renewal and reparation; Fish oil can increase the skin hydration degree, keeps oil-water balance, strengthens skin barrier function, keeps the cell membrane normal configuration, alleviates pore and expands because of over-burden; Hyaluronic acid is the important composition composition of skin, and can promote the marine bioactivity material to be absorbed by cell; V
CThe ability skin whitening makes pore not obvious from appearance.
Compared with prior art, the present invention has following beneficial effect:
1. it is primary raw material that marine organisms function cosmetics of the present invention are selected the marine organism extract of pure natural for use, and contained marine bioactivity material can not bring burden to skin rapidly by skin absorbs, and safety, gentleness, does not also cause skin allergy.
2. marine organisms function cosmetics of the present invention can play the effect of more significant, magical careful pore from inside to outside; Make the pore of expansion be contracted to very little; Can recover real fine and smooth soft and smooth short 4 weeks; The back corse sweat pore symptom of stopping using can not rebound, and the effect of its careful pore is safer, remarkable and lasting.
3. utilize hyaluronic acid, V
CWith the collaborative complex role of marine bioactivity material stabilisation, in marine organisms function cosmetics, add hyaluronic acid and V
C, careful pore effect is significantly improved.
4. the marine organisms function cosmetics among the present invention are numerous in variety, are applicable to the crowd of different sexes, age and skin matter, are particularly useful for having the personage that likes to be beautiful of corse sweat pore puzzlement, can be used as common skin care item or have the function cosmetics of careful pore effect.
The specific embodiment
Following examples are to further specify of the present invention, are not limitations of the present invention.
Embodiment 1:
Get the edible Paphia Undulata that meets China's relevant marine product use standard, add 2 times of volume pure water homogenate 4min behind the internal organs that shell, boil 5min; Add papain after being cooled to room temperature, enzyme concentration is a 1000U/g shellfish meat, under the room temperature behind the 170w ultrasonic Treatment 8min; PH is 7, and temperature is 50 ℃, enzymolysis 60min; Boiling water bath enzyme denaturing 6min; The centrifugal 15min of 8000r/m, supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, makes the Paphia Undulata active peptide powder after the lyophilization.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: glyceryl stearate 6%, polydimethylsiloxane 0.5%, hard alcohol 2%, caprylic/capric triglyceride 4%, octyl stearate 2%, shark oil 0.2%.
B phase: Paphia Undulata bioactive peptide 8%, cod collagen peptide 1%, Porphyra Polysaccharide 0.5%, hyaluronic acid 0.1%, V
C5%, sorbitol 3.25%, HANSHENGJIAO 0.05%, deionized water surplus.
C phase: phenoxyethanol/ethylhexyl glycerol 0.8%
The D phase: sodium hydroxide is regulated pH=5.5.
Technical process: heat respectively A mutually with B to 75 ℃, under the stirring condition, with B be added to A mutually in, homogenizing 3min.Stir cooling, under the room temperature each component of C phase is sequentially added in A, the B phase mixture.Regulate pH=5.5 with sodium hydroxide, make the marine organisms function cosmetic spray that is used for careful pore.The spraying good stability of this embodiment preparation, nothing deposition.
Embodiment 2:
Get the edible Corbiculida and shell and add 2.5 times of volume pure water homogenate 5min behind the internal organs, boil 10min, add bromelain and subtilisin (1:1) after being cooled to room temperature; Enzyme concentration is a 2000U/g shellfish meat, is 6.5 at pH, and temperature is 40 ℃; Enzymolysis 30min, boiling water bath enzyme denaturing 7min, the centrifugal 12min of 6000r/m; Supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, makes the Corbiculida active peptide powder after the lyophilization.
A phase: Corbiculida bioactive peptide 0.5%, sharkskin collagen peptide 0.1%, Sargassum polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, hyaluronic acid 0.3%, V
C10%, deionized water 63.35%.
B phase: carbomer 0.2%.
C phase: deionized water 20%, EDTA-4Na0.05%, Jojoba alcohol, Jojoba oleic acid potassium and butanediol 2%.
D phase: PEG-40 hydrogenated castor grease 1%, trout oil 0.2%, cod fish oil 0.3%.
E phase: propylene glycol, methyl hydroxybenzoate, propyl p-hydroxybenzoate and hydantoin totally 1%.
Technical process: disperse B to A mutually in, Hybrid Heating to 70 ℃-75 ℃.Stir down, C is added in the mixture of A, B phase.In the time of 45 ℃, D phase and E are added in the system mixing.Make the marine organisms function cosmetics water preparation that is used for careful pore.The water preparation of this embodiment preparation does not have deposition, high, the easy absorption of transparency, non-stimulated.
Embodiment 3:
Get edible Margarita, scallop (1:1) and shell and add 3 times of volume pure water homogenate 3min behind the internal organs, add neutral protease and pepsin (1:1), enzyme concentration is a 3000U/g shellfish meat; At pH is 7.5, and temperature is 60 ℃, enzymolysis 60min; Boiling water bath enzyme denaturing 8min; The centrifugal 10min of 7000r/m, supernatant are that the ultrafilter membrane of 3000Da carries out ultrafiltration through molecular cut off, make Margarita and scallop active peptide powder after the lyophilization.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: stearic acid 3%, glyceryl stearate (reaching) PEG-100 stearic acid 3%, gather dimethoxysiloxane 1%, pilchard oil 6%.
B phase: water 16%, carbomer 0.1%.
C phase: Margarita and scallop active peptide 10%, shark cartilage collagen protein peptide 4%, sodium alginate 5%, glycerol 4%, triethanolamine 0.6%, deionized water 47%.
D phase: two imidazolidinyl urea 0.3%.
Technical process: mix the B phase component.Heat respectively A mutually with B to 70 ℃.Stir down, slowly with B be added to A mutually in.Stirring is cooled to 45 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix homogenizing and make the marine organisms function cosmetic emulsion that is used for careful pore.The emulsion feel of this embodiment preparation is fine and smooth, coating is even, profit does not separate, the easy absorption.
Embodiment 4:
Get and meet the edible mussel that the relevant marine product of China uses standard, add 4 times of volume pure water homogenate 4min behind the internal organs that shell, add trypsin and alkaline protease (1:2) after being cooled to room temperature; Enzyme concentration is a 3000U/g shellfish meat; PH is 7, temperature is 50 ℃ of enzymolysis 90min, boiling water bath enzyme denaturing 5min, the centrifugal 15min of 5000r/m; Supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, makes mussel active peptide powder after the lyophilization.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: 16/octadecanol 3%, caprylic/capric triglyceride 2%, ethylhexyl palmitate 4%, salmon fish oil 10%.
B phase: mussel active peptide 0.1%, holothurian collagen peptide 10%, sargassan 1%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 1%, Eucheuma gelatinosum polysaccharide 1%, glycerol 2%, carbomer 0.1%, asiaticoside 0.5%, deionized water surplus.
C phase: Cyclomethicone 4%.
The D phase: sodium hydroxide is regulated pH=5.5.
E phase: parabens 0.5%.
Technical process: heat respectively A mutually with B to 80 ℃, stir time with B be added to A mutually in.Be cooled to 35 ℃, add C phase, D phase and E mutually.Be cooled to room temperature under stirring, make the marine organisms function cosmetics cream frost that is used for careful pore.The cream frost of this embodiment preparation is glossy, exquisite quality, be evenly distributed, profit do not separate mutually.
Embodiment 5:
According to the method for preparing the seashells bioactive peptide in the embodiment 2, enzymolysis makes the oyster active peptides powder.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: HANSHENGJIAO 0.4%, acrylic acid (ester) class/C
10-30Alkylol acrylamide acid esters cross linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, benzophenone-4 0.2%, oyster active peptides 8%, collagen from squid skin peptide 6%, Eucheuma striatum polysaccharide 1%, Hijiki polysaccharide 1%, hyaluronic acid 4%, V
C1%.
B phase: rainbow trout oil 0.5%, Microcanthus strigatus oil 0.5%, ethanol 25%, antiseptic 0.3%, essence 0.1%, butanediol 5%, hydroxyl butyl toluene 0.1%, PEG-40 hydrogenated castor grease 1%, deionized water 3%.
The C phase: triethanolamine, regulate pH=5-5.3, the deionized water surplus.
Technical process: mix the A phase component, stir.Mix the B phase component, homogenizing adds deionized water, is stirred to transparent.With B be added to A mutually in, regulate pH=5-5.3, adding deionized water to total amount is 100%, makes the marine organisms function cosmetic gel that is used for careful pore.The gained gel is transparent in this embodiment, tissue is fine and smooth, do not have caking, under-10 ℃ and 40 ℃ of conditions, and no paste separation.
Embodiment 6:
Mode according to embodiment 1 preparation seashells bioactive peptide makes Paphia Undulata active peptide powder and mussel active peptide powder.
By the shared weight percent meter of each raw material, Paphia Undulata bioactive peptide 3%, mussel active peptide 1%, sharkskin collagen peptide 15%, sargassan 8%, mackerel oil 0.5%, shark oil 1.5%, nanometer Margarita powder 10%, Semen Armeniacae Amarum powder 11%, Mel 5%, V
E2%, deionized water 42%, antiseptic 1%.Paphia Undulata active peptide powder, mussel active peptide powder, sharkskin collagen peptide powder, sargassan are dissolved in the deionized water; After it is all dissolved; Room temperature adds the nanometer Margarita powder and the Semen Armeniacae Amarum powder of mixing in advance down; 50r/m stirring and evenly mixing 5min adds mackerel oil, shark oil, Mel, V again
EAnd antiseptic, stirring and evenly mixing 5min makes the marine organisms function cosmetic mask that is used for careful pore.The facial film of this embodiment preparation is direct-edible, mouthfeel is good, also can directly spread on face, replenishes nutrient and moisture to skin.
Embodiment 7:
Following various cosmetics are carried out animal experiment:
Cosmetic base: 16/octadecanol 3%, caprylic/capric triglyceride 2%, ethylhexyl palmitate 4%, glycerol 2%, carbomer 0.1%, asiaticoside 0.5%, Cyclomethicone 4%, parabens 0.5%, deionized water 83.9%.
The function cosmetics (marine bioactivity material total content is a mass fraction 10%) that " contain the marine bioactivity material ":
A, Paphia Undulata bioactive peptide 8.3%, cod collagen peptide 0.1%, Porphyra Polysaccharide 1%, shark oil 0.6%, above-mentioned cosmetic base 90%;
B, Corbiculida bioactive peptide 0.5%, sharkskin collagen peptide 8%, Sargassum polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, trout oil 0.2%, cod fish oil 0.3%, above-mentioned cosmetic base 90%;
C, active pearl shell peptide 3%, scallop active peptide 2.8%, shark cartilage collagen protein peptide 3%, sodium alginate 1%, pilchard oil 0.2%, above-mentioned cosmetic base 90%;
D, mussel active peptide 2%, holothurian collagen peptide 4%, sargassan 1%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 1%, Eucheuma gelatinosum polysaccharide 1%, salmon fish oil 1%, above-mentioned cosmetic base 90%;
E, oyster active peptides 0.1%, collagen from squid skin peptide 5.9%, Eucheuma striatum polysaccharide 1%, Hijiki polysaccharide 1%, rainbow trout oil 0.5%, Microcanthus strigatus oil 1.5%, above-mentioned cosmetic base 90%;
F, Paphia Undulata bioactive peptide 1%, mussel active peptide 3%, sharkskin collagen peptide 4%, sargassan 0.5%, mackerel oil 0.5%, shark oil 1%, above-mentioned cosmetic base 90%.
" contain hyaluronic acid and V
C" cosmetics: hyaluronic acid 1%, V
C9%, above-mentioned cosmetic base 90%.
" contain marine bioactivity material, hyaluronic acid and V
C" function cosmetics (marine bioactivity material, hyaluronic acid and V
CTotal content is a mass fraction 10%):
A, Paphia Undulata bioactive peptide 5%, cod collagen peptide 0.1%, Porphyra Polysaccharide 1%, shark oil 0.2%, hyaluronic acid 0.7%, V
C3%, above-mentioned cosmetic base 90%;
B, Corbiculida bioactive peptide 0.5%, sharkskin collagen peptide 6%, Sargassum polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, trout oil 0.2%, cod fish oil 0.3%, hyaluronic acid 0.2%, V
C1.8%, above-mentioned cosmetic base 90%;
C, active pearl shell peptide 2%, scallop active peptide 2%, shark cartilage collagen protein peptide 2%, sodium alginate 1%, pilchard oil 1%, hyaluronic acid 1%, V
C1%, above-mentioned cosmetic base 90%;
D, mussel active peptide 0.1%, holothurian collagen peptide 3.9%, sargassan 0.5%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 0.5%, Eucheuma gelatinosum polysaccharide 1%, salmon fish oil 1%, hyaluronic acid 1%, V
C2%, above-mentioned cosmetic base 90%;
E, oyster active peptides 2%, collagen from squid skin peptide 1%, Eucheuma striatum polysaccharide 1%, Hijiki polysaccharide 1%, rainbow trout oil 0.5%, Microcanthus strigatus oil 0.5%, hyaluronic acid 1%, V
C3%, above-mentioned cosmetic base 90%;
F, Paphia Undulata bioactive peptide 1%, mussel active peptide 3%, sharkskin collagen peptide 2.9%, sargassan 0.5%, mackerel oil 0.5%, shark oil 1%, hyaluronic acid 0.1%, V
C1%, above-mentioned cosmetic base 90%.
Smear 56 rats with 10% sodium sulfide solution, male and female half and half are divided into 14 groups at random, promptly cosmetic base group, " containing the marine bioactivity material " function cosmetics group (a, b, c, d, e, f), " contain hyaluronic acid and V
C" the cosmetics group, " contain marine bioactivity material, hyaluronic acid and V
C" function cosmetics group (A, B, C, D, E, F), 4 every group.
The processing of losing hair or feathers of rat back right side, after a period of time with warm water cleaning depilation place, one day cosmetic applying of preparing of twice usefulness sooner or later.2 week backs are scratched the wound of a treaty 2-3cm in back, right side depilation place same position with scalpel, and precision is measured cut length.Cut wound healing rate is measured in 3 all backs, according to formula: wound healing rate %=(wound length before smearing-wound length after smearing)/smear preceding wound length * 100%, respectively organizes healing rate.Behind the 30d rat back skin is evenly taken off, examine under a microscope epiderm skin pore pore size and roughness, and contrast with the cosmetic base group.Experimental result is seen table 1-3.
The cosmetics group healing rate that has added active substance is obviously high than cosmetic base group, is followed successively by from high to low by healing rate " to contain marine bioactivity material, hyaluronic acid and V
C" function cosmetics group, " containing the marine bioactivity material " function cosmetics group, " contain hyaluronic acid and V
C" the cosmetics group, this explains that marine bioactivity material function cosmetics of the present invention can significantly promote the rat skin wound healing.Adding hyaluronic acid and V
CAfter, its wound healing rate is far above " containing hyaluronic acid and V
C" the cosmetics group, also the wound healing rate than " containing the marine bioactivity material " function cosmetics group is high, this explanation hyaluronic acid and V
CHave good forward synergism with the marine bioactivity material, can make it promote the wound healing effect significantly to strengthen.
Behind the 30d, added the cosmetics of active substance the improvement situation of degree of compacting, roughness and the appearance of pores of rat skin obviously has been superior to the cosmetic base group, be followed successively by from high to low by the improvement situation and " contain marine bioactivity material, hyaluronic acid and V
C" function cosmetics group, " containing the marine bioactivity material " function cosmetics group, " contain hyaluronic acid and V
C" the cosmetics group, this order is identical with wound healing rate order from high to low.The function cosmetics group that " contains the marine bioactivity material " with " contain marine bioactivity material, hyaluronic acid and V
C" rat skin of function cosmetics group more compacts, pore is fine and smooth evenly, the aperture obviously diminishes; And the skin of cosmetic base group is loose, irregular, the pore varying aperture is not obvious; " contain hyaluronic acid and V
C" skin of cosmetics group is also comparatively loose, irregular, though skin-tightening degree, roughness and pore situation make moderate progress DeGrain.This explanation hyaluronic acid and V
CHave good forward synergism with the marine bioactivity material, can make its degree of compacting, roughness and pore improve effect and significantly strengthen skin.
Experimental result shows that the cosmetics among the present invention have remarkable promotion wound healing, the effect of compact skin and careful pore.
Embodiment 8
Cosmetics to embodiment 1-6 preparation carry out human body experiment on probation.Choose 30 of healthy volunteers such as the skin of face pore is thicker, pachylosis, each 15 of man, woman, age 20-60 year; Mean age is (31.2 ± 5.4) year; Do not have serious systemic disease, no immunodeficiency or autoimmune disease, cosmetics are not had serious allergies, facial NAI, do not use hormone medicine or immunosuppressant, do not participate in other clinical trials, do not smear external preparation such as cosmetics; Be divided into 6 groups at random, 5 every group.
The experimenter cleans face with warm water earlier, then cosmetics evenly is applied to face, every day each 1 time sooner or later; (the facial film method for using of embodiment 6 preparation was: after the warm water cleaning face facial film is applied to the 10-15min of face totally 4 weeks; Clean with clear water, 1 time every night, totally 4 weeks).Respectively follow up a case by regular visits to and test 1 time before using with after using for 1,2,3,4 weeks.Select the facial same position of homonymy as the test target site; Instrument test skin pore aperture adopts the DIGIMIC800 type skin image analyser of BJ University of Aeronautics & Astronautics's development to front and back same position (mid point of the wing of nose or the wing of nose and the outside, homonymy canthus line) pore shooting (amplifying 20 times), analyzes and draws the pore pore size.Use front and back skin pore pore size to change through comparative product, the careful pore effect of assessment cosmetics.
The function cosmetics that the experimenter is contained the marine bioactivity material in use are after 1 week, and skin of face pore aperture ratio obviously diminishes before using (P < 0.05), and along with the cosmetics prolongation of service time, the pore aperture continues to diminish.After using for 4 weeks continuously, totally 24 experimenter's skin pores have slight improvement, have 4 moderates to improve, and the result sees table 4.
After using 4 weeks of marine organisms function cosmetics among the present invention; The skin pore aperture dwindles obviously, and elasticity and degree of compacting also significantly increase, and the wrinkle stricture of vagina that shoals, expresses one's feelings disappears; It is moist, soft and smooth that skin becomes; Skin blemishes such as erythema/pimple are thin out, and the colour of skin is bright, pale, and pore obviously becomes careful, not obvious generally.Can judge among the present invention marine organisms function cosmetics to facial skin have significantly, the comprehensively effect of careful pore from inside to outside.
Claims (1)
1. marine organisms function cosmetics that are used for careful pore is characterized in that the active component of forming these marine organisms function cosmetics comprises seashells bioactive peptide, marine collagen protein peptide, Sargassum polysaccharides and fish oil; Described seashells is one or more the combination in Paphia Undulata, Corbiculida, Margarita, scallop, mussel, the Concha Ostreae; The marine collagen protein peptide is cod collagen peptide, sharkskin collagen peptide, shark cartilage collagen protein peptide, holothurian collagen peptide or collagen from squid skin peptide; Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide, the Hijiki polysaccharide; Said fish oil is meant bathypelagic fish oil, and said bathypelagic fish is one or more the combination in shark, salmon, morrhua, sardine, salmon fish, rainbow trout, Microcanthus strigatus, the mackerel.
2. the marine organisms function cosmetics that are used for careful pore as claimed in claim 1 is characterized in that forming the weight content of this marine organisms function cosmetics main active in cosmetics and are: seashells bioactive peptide 0.1%-10%, marine collagen protein peptide 0.1%-15%, Sargassum polysaccharides 0.5%-8%, fish oil 0.2%-10%.
3. the marine organisms function cosmetics that are used for careful pore as claimed in claim 1 is characterized in that forming the weight content of this marine organisms function cosmetics main active in cosmetics and are: seashells bioactive peptide 0.5%-10%, marine collagen protein peptide 1%-10%, Sargassum polysaccharides 1%-5%, fish oil 0.5%-6%.
4. like claim 1, the 2 or 3 described marine organisms function cosmetics that are used for careful pore; It is characterized in that the active component of forming these marine organisms function cosmetics also comprises hyaluronic acid and Vc, the weight content in cosmetics is hyaluronic acid 0.1%-4% and V
C1%-10%.
5. like claim 1, the 2 or 3 described marine organisms function cosmetics that are used for careful pore; It is characterized in that said seashells bioactive peptide is meant the seashells bioactive peptide mixture that makes after ocean shellfish meat is through protease hydrolyzed, the ultrafiltration of 3000Da ultrafilter membrane; Said seashells is meant one or more the combination in Paphia Undulata, Corbiculida, Margarita, scallop, mussel, the Concha Ostreae, and said protease is one or more the combination in bromelain, papain, neutral protease, alkaline protease, pepsin, trypsin, the subtilisin.
6. like claim 1, the 2 or 3 described marine organisms function cosmetics that are used for careful pore, it is characterized in that said marine organisms function cosmetics are cream frost, emulsion, water preparation, gel, spraying or facial film.
7. like claim 1, the 2 or 3 described marine organisms function cosmetics that are used for careful pore, it is characterized in that said cosmetics can be used as ordinary cosmetics or have the function cosmetics of careful pore effect.
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