CN108618986A - A kind of moisturizing anti-wrinkle Multifunctional mask liquid and preparation method thereof - Google Patents
A kind of moisturizing anti-wrinkle Multifunctional mask liquid and preparation method thereof Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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Abstract
The invention belongs to cosmetic technical fields, and in particular to a kind of moisturizing anti-wrinkle Multifunctional mask liquid and preparation method thereof.The moisturizing anti-wrinkle Multifunctional mask liquid includes L fucoses, lysolecithin, carboxymethylchitosan, lactobionic acid, arginine, Sodium Hyaluronate, glycerine, polyglycereol 10, the components such as ammonium acryloyl taurate/VP copolymer and glycerin polyether 26, it can be acted on from dermal layer of the skin to epidermis, with moisturizing, anti-wrinkle, desalinate microgroove, enhance elasticity of skin, anti-aging and other effects, and after deactivating, there is no rebound phenomena, it is not in erythema when use, the adverse reactions such as oedema, it is safe and non-stimulating, the proliferation of human skin fibroblasts can also be remarkably promoted, promote skin injury reparation.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of moisturizing anti-wrinkle Multifunctional mask liquid and its preparation side
Method.
Background technology
With social progress and development, the increasingly raising of living standard, cosmetics have become can not in modern life
An or scarce part.And with the increase at age, the regeneration function of the epidermal layer cells of human skin declines, and skin lacks nutrition
It can become to dry and occur groove, groove forms the gap of the different degrees of depth in face.With the passing of the years, these lines
Ditch is constantly deepened, and reaches up to the corium confluent monolayer cells that support entire skin surface as spring, human facial skin is made to occur
The phenomenon that wrinkle increases.And the main reason for cutis laxa, is, the thickness of dermal layer of the skin can become with advancing age
It is thin, every 10 years thinning 7%, while the collagenous fibres in skin can recombinate, elastomer can dissolve, and skin elasticity reduces, surely
After cortex follows the string, skin just becomes loose.Long it, longer, broader deep wrinkle gradually forms, cutis laxa, to people
Work, life generate negative influence.
Chinese patent application CN104814919A discloses a kind of moisturizing anti-wrinkle facial mask liquid, manufacturing method and moisturizing anti-wrinkle face
Film, the facial mask liquid are protected by polymer hyaluronic acid sodium, oligomerization Sodium Hyaluronate, disodium ethylene diamine tetraacetate, anti-sensitizer, first
Humectant, preservative, oligopeptides, the second moisturizer, yeast extract and deionized water are made, which has reparation skin impaired
Partly, accelerate skin new life process, promote fibrocyte and epidermal cell metabolism, improve compact sense and the satiety of skin, subtract
The effect of light skin pattern symptom, is finally reached efficient moisturizing anti-wrinkle effect.But the facial mask focuses on the raising of moistening effect,
Anti-wrinkle effect cannot still meet the daily need of consumer, and the phenomenon that there is also rebound.
Chinese patent application CN106214621A discloses a kind of with reduction wrinkle of skin and increase moisture of skin effect
Facial mask, the facial mask mainly by west safflower extracting solution, fritillaria thunbergii extracting solution, Sodium Hyaluronate, Isin glue collagen, yeast extract
Liquid, ceramide, oat extracting solution, 1,2- butanediols, 1,4- butanediols, double-PEG-18 methyl ethers dimethylsilanes, tartaric acid,
Lecithin, tetrahydrochysene methylpyrimidine carboxylic acid, glycerine etc. are made.It is larger that the facial mask overcomes traditional Chinese medicine limitation directly for oral administration, milling
Facial mask is added to be difficult to apply exhibition again, is easy the shortcomings of formation is local to unite, and assimilation effect is bad, use is easier, and effect is more notable.
But contains tartaric acid in the facial mask, easy to produce allergic reaction and calcination damage, skin is made erythema occur, oedema, ooze out, itch
It needs to use with caution Deng local adverse reaction, especially allergic constitution, the consumer for having immunodeficiency type disease, skin disease etc..
Therefore, there is an urgent need to develop it is a kind of it is safe and non-stimulating, can to remarkably promote fibroblast proliferation, anti-wrinkle effect aobvious
It writes, anti-aging, and the moisturizing anti-wrinkle Multifunctional mask liquid and preparation method thereof not rebounded after.
Invention content
The present invention is intended to provide a kind of moisturizing anti-wrinkle Multifunctional mask liquid and preparation method thereof, the facial mask liquid is stingless safely
Swash, fibroblast proliferation, anti-wrinkle significant effect, anti-aging can be remarkably promoted, and does not rebound after.
In order to achieve the above object, the present invention uses following technical scheme：
A kind of moisturizing anti-wrinkle Multifunctional mask liquid, the facial mask liquid are made of the component of following mass percent：0.05~
0.2%L- fucoses, 0.05~0.2% lysolecithin, 0.02~0.1% carboxymethylchitosan, 0.01~0.1%
Lactobionic acid, 0.01~0.1% arginine, 0.05~0.2% Sodium Hyaluronate, 1~4% glycerine, 0.5~3% Natrulon H-10,
0.2~0.5% ammonium acryloyl taurate/VP copolymer, 1~3% glycerin polyether -26,0.4~1%1,2- hexylene glycols,
0.3~0.5% parahydroxyacet-ophenone, 0.1~1% recombination human source collagen stoste, 0.1~1% rough gentian anti-irritant factor and
Balance deionized water.
Further, the facial mask liquid is made of the component of following mass percent：0.1%L- fucoses, 0.1% haemolysis
Lecithin, 0.05% carboxymethylchitosan, 0.05% lactobionic acid, 0.05% arginine, 0.15% Sodium Hyaluronate,
2% glycerine, 2% Natrulon H-10,0.3% ammonium acryloyl taurate/VP copolymer, 2% glycerin polyether -26,0.6%
1,2- hexylene glycols, 0.3% parahydroxyacet-ophenone, 0.5% recombination human source collagen stoste, the 0.2% rough gentian anti-irritant factor and
Balance deionized water.
Further, the molecular weight of the Sodium Hyaluronate is 1.2 × 106。
Further, the preparation method of the facial mask liquid is：
S1, the ammonium acryloyl taurate/VP copolymer for taking corresponding amount, Sodium Hyaluronate, Natrulon H-10, glycerine
Polyethers -26 and glycerine, and be added sequentially to stir evenly in reactor, then it is charged with the deionization of corresponding amount 94~95%
Water is heated to 80~85 DEG C, obtains solution A after stirring evenly；
S2, the parahydroxyacet-ophenone for taking corresponding amount and 1,2- hexylene glycols, and 80~85 DEG C are heated to, it stirs evenly,
Obtain solution B；
The deionized water of S3, the carboxymethylchitosan for taking corresponding amount and residual mass percentage are dispersed with stirring
It is even, obtain solution C；
S4, step S2 acquired solutions B is added in step S1 acquired solutions A and is stirred evenly, adjust the temperature to 40~
45 DEG C, sequentially add the recombination human source collagen stoste of corresponding amount, the rough gentian anti-irritant factor, lysolecithin, L- rock algaes
Sugar, lactobionic acid, arginine and step S3 acquired solution C, stir evenly to get.
In addition, the present invention also provides a kind of preparation method of moisturizing anti-wrinkle Multifunctional mask liquid, the preparation methods
For：
S1, the ammonium acryloyl taurate/VP copolymer for taking corresponding amount, Sodium Hyaluronate, Natrulon H-10, glycerine
Polyethers -26 and glycerine, and be added sequentially to stir evenly in reactor, then it is charged with the deionization of corresponding amount 94~95%
Water is heated to 80~85 DEG C, obtains solution A after stirring evenly；
S2, the parahydroxyacet-ophenone for taking corresponding amount and 1,2- hexylene glycols, and 80~85 DEG C are heated to, it stirs evenly,
Obtain solution B；
The deionized water of S3, the carboxymethylchitosan for taking corresponding amount and residual mass percentage are dispersed with stirring
It is even, obtain solution C；
S4, step S2 acquired solutions B is added in step S1 acquired solutions A and is stirred evenly, adjust the temperature to 40~
45 DEG C, sequentially add the recombination human source collagen stoste of corresponding amount, the rough gentian anti-irritant factor, lysolecithin, L- rock algaes
Sugar, lactobionic acid, arginine and step S3 acquired solution C, stir evenly to get.
In addition, the present invention also provides a kind of the moisturizing anti-wrinkle Multifunctional mask containing the facial mask liquid, the moisturizing
Anti-wrinkle Multifunctional mask further includes facial mask primary backing.
Further, the one kind of the facial mask primary backing in non-woven fabrics, cotton, silk fabric, biological fiber cloth.
L-fucose can enhance dermis of skin layer thickness, biosynthesis, precipitation and the increasing of stimulation of elastin in the present invention
Add the density of elastomer；Lysolecithin can reduce percutaneous water loss, lock skin moisture and enhance skin barrier work(
Can, the elasticity and sophistication of skin can be improved；Carboxymethylchitosan interacts with epidermal lipid film layer, and one layer of formation is excellent
Different natural bionics skin (natural sterile film) has immunoregulatory activity, can effectively facilitate wound healing, reduces moisture stream
It loses, while being combined with L-fucose, the ability of L-fucose enhancing dermis of skin layer thickness can be promoted；Lactobionic acid can promote epidermis
Layer is old useless and abnormal cutin falls off, and increases the speed of epithelial cell metabolism, when acting on skin corium, glass can be stimulated to urinate
Acid, mucopolysaccharide, collagen and elastic fibers hyperplasia and rearrange, so that the water content of skin is increased, can with L-fucose
Synergistic effect, so that skin is become, consolidation is flexible, and microgroove and wrinkle can also be reduced therewith；Arginine can be used for adjusting facial mask liquid
pH.Above 5 kinds of components are by compounding, along with the overall coordination of remaining component acts on, from inside to outside, from dermal layer of the skin to table
The problems such as cortex, various dimensions fundamentally solve dry skin, wrinkle, relaxation, has moisturizing, anti-wrinkle, desalination microgroove, enhancing flesh
Skin elasticity, anti-aging and other effects.Test example 3 is it can be proved that facial mask liquid prepared by the embodiment of the present invention 1 can be slight or be obviously improved
The skin elasticity and moisture of volunteer, and deactivate 4 weeks after effect there is no significant change, without rebound phenomena send out
It is raw；Test example 4 it can be proved that the embodiment of the present invention 1 prepare facial mask liquid wrinkle volunteer's number of cases can be made to significantly reduce, do not wrinkle
Line number of cases accounts for the 84% of total number of persons, and without the volunteer of severe aging, can notable moisturizing anti-wrinkle, anti-aging.
Meanwhile applicant's pleasantly surprised discovery in practice, L-fucose, lysolecithin, the deacetylated shell of carboxymethyl is more
Sugar, lactobionic acid and arginine press a certain amount of compounding, along with the whole interaction of remaining component, can also remarkably promote fell
The fibroblastic proliferation of skin promotes skin injury reparation.Test example 2 of the present invention is it can be proved that prepared by the embodiment of the present invention 1
Facial mask liquid can remarkably promote the proliferation of human fibroblasts, and the cell number in third day is close to 3 × 104A/ml, significantly more than compares
Face prepared by example 1~4 (removing L-fucose, lysolecithin, carboxymethylchitosan, lactobionic acid and arginine respectively)
The human fibroblasts of film liquid culture.
In addition, the lactobionic acid contained in the application is one kind of tartaric acid, easy tos produce allergic reaction and calcination damage,
Skin is set the local adverse reaction such as erythema occur, oedema, ooze out, itch.But applicant is found surprisingly that in practice, by L- rocks
Algae sugar, lysolecithin, carboxymethylchitosan, lactobionic acid and arginine press a certain amount of compounding, add remaining component
Whole interaction, can be to avoid the generation of the adverse reactions such as erythema, oedema.Test example 1 is it can be proved that in skin irritation
In observation period in experiment, 1~3 tested new zealand rabbit skin of the embodiment of the present invention has no erythema, the abnormal responses such as oedema, not
It was found that other poisoning symptoms, in test each observing time point highest stimulus index is not 0, and comparative example 1~4 (is gone respectively
Fall L-fucose, lysolecithin, carboxymethylchitosan, lactobionic acid and arginine) facial mask liquid for preparing is to tested new
Western orchid man rabbit skin has different degrees of irritation adverse reaction；Test example 4 can also prove that the embodiment of the present invention 1 is 90
There are not the adverse reactions such as erythema, oedema during it experiment, and comparative example 1~4 (removes L-fucose, haemolysis respectively
Lecithin, carboxymethylchitosan, lactobionic acid and arginine) prepare facial mask liquid during the test, have 5~10% will
Hope person's reaction has the adverse reactions such as erythema oedema.
The present invention has the following advantages：
(1) a kind of moisturizing anti-wrinkle Multifunctional mask liquid of the present invention, can be acted on from dermal layer of the skin to epidermis, be had
Moisturizing, anti-wrinkle, desalination microgroove, enhancing elasticity of skin, anti-aging and other effects, and after deactivating, without rebound phenomena.
(2) a kind of moisturizing anti-wrinkle Multifunctional mask liquid of the present invention, safe and non-stimulating, Skin Irritation Test and clinical test are equal
Prove the facial mask liquid for preparing of the present invention using when be not in the adverse reactions such as erythema, oedema.
(3) a kind of moisturizing anti-wrinkle Multifunctional mask liquid of the present invention, can remarkably promote the proliferation of human skin fibroblasts, promote
Into skin injury reparation.
Description of the drawings
Fig. 1 is fibroblastic growth situation.
Specific implementation mode
The specific implementation mode of form by the following examples makees further specifically the above of the present invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
Agents useful for same of the present invention is common agents, can be bought in reagent manufacturing enterprise.
A kind of moisturizing anti-wrinkle Multifunctional mask liquid of Examples 1 to 3
1~3 moisturizing anti-wrinkle Multifunctional mask liquid component of the embodiment of the present invention and its weight percent (%) such as 1 institute of table
Show.
1 embodiment of the present invention of table, 1~3 moisturizing anti-wrinkle Multifunctional mask liquid component and its weight percent (%)
Preparation method：
S1, the ammonium acryloyl taurate/VP copolymer for taking corresponding amount, Sodium Hyaluronate, Natrulon H-10, glycerine
Polyethers -26 and glycerine, and be added sequentially to stir evenly in reactor, then it is charged with the deionized water of corresponding amount 95%,
It is heated to 85 DEG C after stirring evenly, obtains solution A；
S2, the parahydroxyacet-ophenone for taking corresponding amount and 1,2- hexylene glycols, and 85 DEG C are heated to, it stirs evenly, obtains molten
Liquid B；
The deionized water of S3, the carboxymethylchitosan for taking corresponding amount and residual mass percentage are dispersed with stirring
It is even, obtain solution C；
S4, step S2 acquired solutions B is added in step S1 acquired solutions A and is stirred evenly, adjust the temperature to 45 DEG C,
Sequentially add the recombination human source collagen stoste of corresponding amount, the rough gentian anti-irritant factor, lysolecithin, L-fucose, breast
Saccharic acid, arginine and step S3 acquired solution C, stir evenly to get.
A kind of 1 facial mask liquid of comparative example
Difference from Example 1 is that comparative example 1 removes L-fucose, and the dosage of deionized water increases to 91.7%,
Remaining component and preparation method reference implementation example 1.
A kind of 2 facial mask liquid of comparative example
Difference from Example 1 is that comparative example 2 removes lysolecithin, and the dosage of deionized water increases to
91.7%, remaining component and preparation method reference implementation example 1.
A kind of 3 facial mask liquid of comparative example
Difference from Example 1 is that comparative example 3 removes carboxymethylchitosan, and the dosage of deionized water increases
91.65% is added to, remaining component and preparation method reference implementation example 1.
A kind of 4 facial mask liquid of comparative example
Difference from Example 1 is that comparative example 4 removes lactobionic acid and arginine, and the dosage of deionized water increases to
91.7%, remaining component and preparation method reference implementation example 1.
1 Skin Irritation Test of test example
1. test material：Facial mask liquid prepared by Examples 1 to 3 and comparative example 1~4.
2. subjects：Healthy new zealand rabbit 70,180~220g of weight.
3. test method：
Test method refers to《Cosmetics safety technical specification》Skin irritation/the corrosion test of (version in 2015), it is right
According to the other side normal skin for same test animal, standards of grading are shown in Table 2.
2 skin wound repair of table scores
4. test result：
3 Skin Irritation Test result of table
As can be seen from Table 3, in the observation period, the tested new zealand rabbit skin of Examples 1 to 3 has no that erythema, oedema etc. are different
Paradoxical reaction does not find other poisoning symptoms, and in test each observing time point highest stimulus index is not 0, therefore skin pierces
Swash experiments have shown that the moisturizing anti-wrinkle Multifunctional mask liquid of the preparation of the embodiment of the present invention 1~3 is nonirritant.And prepared by comparative example 1~4
Facial mask liquid have different degrees of irritation erythema, oedema adverse reaction to tested new zealand rabbit skin.
The influence that test example 2 is proliferated Fibroblasts in vitro
1. test material：Facial mask liquid prepared by embodiment 1 and comparative example 1~4.
2. subjects：Human skin fibroblasts HFF-1 is purchased from Chinese Academy of Sciences's stem cell bank, number：SCSP-
109。
3. test method：
The accurate each 0.1g of facial mask liquid for weighing embodiment 1 and comparative example 1~4 and preparing, is dissolved in ethanol solution, fills
Mixing, centrifugation is divided to abandon precipitation, supernatant is for testing.The human fibroblasts of culture are digested and are diluted to 1 with Hanks liquid
×104Human fibroblasts dilution is inoculated in culture plate by a/ml, and culture medium is added with 1% concentration in given the test agent
In.Routine culture cell is carried out, takes three parallel samples to count for every group daily, continuous counter 3 days draws cell growth curve.
4. test result：
Experimental result is shown in Fig. 1, it is seen that facial mask liquid prepared by the embodiment of the present invention 1 can remarkably promote the increasing of human fibroblasts
It grows, and facial mask liquid prepared by comparative example 1~4 can also promote the proliferation of human fibroblasts, but growth rate and life to a certain degree
Long ability is significantly reduced compared with embodiment 1.
3 human body application test of test example
1. test material：Facial mask liquid prepared by embodiment 1 and comparative example 1~4.
2. subjects：150 25~40 one full year of life health volunteers.
3. test method：
Volunteer is randomly divided into 5 groups by the principle of parallel control, every group of 30 people try out 1 He of the embodiment of the present invention respectively
Comparative example 1~4 prepare facial mask liquid, daily morning and evening in facial application after face cleaning, using 4 weeks, respectively test use before (0 week),
Using after 1 week, using after 2 weeks, using after 3 weeks, using after 4 weeks, after 8 weeks (using suspending again after 4 weeks using after 4 weeks) skin water
The case where part content and skin elasticity index, tests 5 data and is averaged every time, and instrument is Germany COURAGE+
The skin moisture tester Corneometer CM825 and skin elasticity tester Cutometer of KHAZAKA (CK) company production
dual MPA580。
4. test result：
Skin moisture increases percentage amounts to volunteer weekly and elasticity indexes increase percentage amounts and refer to table 4.Evaluation index in table
Slightly improve including skin and be obviously improved two grades, number accumulates superposition at any time.Wherein, slight improve refers to having improvement
Under the premise of compared with (0 week) before test skin moisture increase percentage amounts<5%, elasticity indexes increase percentage amounts<5%；Obviously change
Kind refers to that skin moisture increases percentage amounts >=5% compared with (0 week) before test, and elasticity indexes increase percentage amounts >=5%, and (two all
Meet), slightly improve and is obviously improved misaligned.
Skin improves degree to 4 volunteer of table weekly
As shown in Table 4, the embodiment of the present invention 1 can skin elasticity and moisture slight or that be obviously improved volunteer, and
And effect does not have significant change after deactivating 4 weeks.And facial mask liquid prepared by comparative example 1~4 also can be slight or be obviously improved will
The skin elasticity and moisture of hope person, but improvement is significantly reduced compared with embodiment 1, is held time also shorter, after deactivating 4 weeks
It is easy rebound.
4 anti-aging clinical observation of test example
1. test material：Facial mask liquid prepared by embodiment 1 and comparative example 1~4.
2. subjects：The female volunteers of 300 28~50 one full year of life healths.Inclusion criteria：Dry skin, elasticity
It reduces, the skin ageing phenomenons such as wrinkle, pigmentation, the colour of skin be gloomy occurs；It is ready to avoid solarization during entire experiment, or connects
Face uses the sunscreen product of SPF >=30 when touching sunlight；Other anti-aging products are not used during entire experiment.
3. test method：
Tested volunteer is randomly divided into 5 groups, every group 60, early, after late face cleaning each group uses embodiment 1 and comparison respectively
Facial mask liquid prepared by example 1~4.Test period is 90 days, the adverse reaction occurred during record experiment, at the 90th day to subject
Carry out skin aging assessment.
4. experimental result：
Test result is shown in Table 5, and wherein skin aging assessment is evaluated by the wrinkle in 5 tested areas of observation subject
(glabella line, forehead line, crow's feet, nasolabial groove, lip week wrinkle), judgment criteria are no wrinkle；Slightly：There are 2~3 shallow wrinkles
Line, length ＜ 1.5cm；Moderate：There are 2~6 shallow wrinkles, length ＜ 3cm；Severe：There are several main wrinkles, length to reach 4cm, simultaneously
With shallow wrinkle.
The skin aging of 5 tested volunteer of table is assessed
As shown in Table 5, embodiment 1 is significantly reduced relative to the wrinkle number of cases of comparative example 1~4, and no wrinkle number of cases accounts for always
The 84% of number, without the volunteer of severe aging, can significantly moisturizing anti-wrinkle, anti-aging, and do not go out during the test
The adverse reactions such as existing erythema, oedema.And facial mask liquid prepared by comparative example 1~4 still has the volunteer of severe aging after use, does not have
There is wrinkle number of cases to account for total number of persons 36~54%, during the test, there is 5~10% volunteers reaction to have erythema oedema etc. bad anti-
It answers, can die away after a period of time.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should by the present invention claim be covered.
Claims (7)
1. a kind of moisturizing anti-wrinkle Multifunctional mask liquid, which is characterized in that the facial mask liquid by following mass percent component system
At：0.05~0.2%L- fucoses, 0.05~0.2% lysolecithin, 0.02~0.1% carboxymethylchitosan,
0.01~0.1% lactobionic acid, 0.01~0.1% arginine, 0.05~0.2% Sodium Hyaluronate, 1~4% glycerine, 0.5~3%
Natrulon H-10,0.2~0.5% ammonium acryloyl taurate/VP copolymer, 1~3% glycerin polyether -26,0.4~1%
1,2- hexylene glycols, 0.3~0.5% parahydroxyacet-ophenone, 0.1~1% recombination human source collagen stoste, 0.1~1% rough gentian are anti-
Stimulating factor and balance deionized water.
2. facial mask liquid as described in claim 1, which is characterized in that the facial mask liquid is made of the component of following mass percent：
0.1%L- fucoses, 0.1% lysolecithin, 0.05% carboxymethylchitosan, 0.05% lactobionic acid, 0.05% essence
Propylhomoserin, 0.15% Sodium Hyaluronate, 2% glycerine, 2% Natrulon H-10,0.3% ammonium acryloyldime-thyltaurate/VP copolymerization
Object, 2% glycerin polyether -26,0.6%1,2- hexylene glycols, 0.3% parahydroxyacet-ophenone, 0.5% recombination human source procollagen
Liquid, the 0.2% rough gentian anti-irritant factor and balance deionized water.
3. facial mask liquid as claimed in claim 1 or 2, which is characterized in that the molecular weight of the Sodium Hyaluronate is 1.2 × 106。
4. facial mask liquid as claimed in claim 1 or 2, which is characterized in that the preparation method of the facial mask liquid is：
S1, the ammonium acryloyl taurate/VP copolymer for taking corresponding amount, Sodium Hyaluronate, Natrulon H-10, glycerin polyether-
26 and glycerine, and be added sequentially to stir evenly in reactor, then it is charged with the deionized water of corresponding amount 94~95%, it stirs
80~85 DEG C are heated to after mixing uniformly, obtains solution A；
S2, the parahydroxyacet-ophenone for taking corresponding amount and 1,2- hexylene glycols, and 80~85 DEG C are heated to, it stirs evenly, obtains molten
Liquid B；
The deionized water of S3, the carboxymethylchitosan for taking corresponding amount and residual mass percentage are dispersed with stirring uniformly, obtain
Solution C；
S4, step S2 acquired solutions B is added in step S1 acquired solutions A and is stirred evenly, adjust the temperature to 40~45 DEG C,
Sequentially add the recombination human source collagen stoste of corresponding amount, the rough gentian anti-irritant factor, lysolecithin, L-fucose, breast
Saccharic acid, arginine and step S3 acquired solution C, stir evenly to get.
5. a kind of preparation method of moisturizing anti-wrinkle Multifunctional mask liquid, which is characterized in that the preparation method is that：
S1, the ammonium acryloyl taurate/VP copolymer for taking corresponding amount, Sodium Hyaluronate, Natrulon H-10, glycerin polyether-
26 and glycerine, and be added sequentially to stir evenly in reactor, then it is charged with the deionized water of corresponding amount 94~95%, it stirs
80~85 DEG C are heated to after mixing uniformly, obtains solution A；
S2, the parahydroxyacet-ophenone for taking corresponding amount and 1,2- hexylene glycols, and 80~85 DEG C are heated to, it stirs evenly, obtains molten
Liquid B；
The deionized water of S3, the carboxymethylchitosan for taking corresponding amount and residual mass percentage are dispersed with stirring uniformly, obtain
Solution C；
S4, step S2 acquired solutions B is added in step S1 acquired solutions A and is stirred evenly, adjust the temperature to 40~45 DEG C,
Sequentially add the recombination human source collagen stoste of corresponding amount, the rough gentian anti-irritant factor, lysolecithin, L-fucose, breast
Saccharic acid, arginine and step S3 acquired solution C, stir evenly to get.
6. a kind of facial mask prepared containing the facial mask liquid as described in claims 1 to 3 is any or by preparation method as described in claim 5
The moisturizing anti-wrinkle Multifunctional mask of liquid, which is characterized in that the moisturizing anti-wrinkle Multifunctional mask further includes facial mask primary backing.
7. a kind of moisturizing anti-wrinkle Multifunctional mask as claimed in claim 6, which is characterized in that the facial mask primary backing is selected from nonwoven
One kind in cloth, cotton, silk fabric, biological fiber cloth.
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| CN110037939A (en) * | 2019-05-13 | 2019-07-23 | 广东瀚森生物科技有限公司 | A kind of more effect facial mask stostes and preparation method thereof |
| CN111821219A (en) * | 2020-08-17 | 2020-10-27 | 广东丸美生物技术股份有限公司 | Composition with moisturizing effect and application thereof |
| CN113181531A (en) * | 2021-04-26 | 2021-07-30 | 上海应用技术大学 | Human body healthy skin irritation model and establishment method thereof |
| CN115778845A (en) * | 2023-02-07 | 2023-03-14 | 荷本世新(北京)生物科技有限公司 | Protein composition and preparation method and application thereof |
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Application publication date: 20181009 |