CN109528554A - A kind of preparation method of anti-wrinkle composition and its cataplasm - Google Patents
A kind of preparation method of anti-wrinkle composition and its cataplasm Download PDFInfo
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- CN109528554A CN109528554A CN201811503035.1A CN201811503035A CN109528554A CN 109528554 A CN109528554 A CN 109528554A CN 201811503035 A CN201811503035 A CN 201811503035A CN 109528554 A CN109528554 A CN 109528554A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention relates to the preparation methods of a kind of anti-wrinkle composition and its cataplasm, it is characterized by: consisting of the following mass percentage components: L-fucose 15-25%, 1,5- dehydration-D- glucitol 15-25%, inositol 10-20%, allitol 5-10%, D-Psicose 5-10%, deionized water 20%.Anti-wrinkle composition and its cataplasm prepared by the present invention have good transdermal characteristic, low irritant and good crease-resistant effect.
Description
Technical field
The present invention relates to technical field of cosmetic preparation, in particular to the preparation side of a kind of anti-wrinkle composition and its cataplasm
Method.
Background technique
With age, skin natural aging generates wrinkle and is inevitable.In addition to this, excessive illumination, air
Under the stimulation of the external factor such as pollution, skin barrier breakdown, water loss, elastin laminin is reduced, collagen fabric attenuates quantity
It reduces, the drying of skin change is followed the string and supported, and wrinkle also just generates therewith.
At present the common crease-resistant both effectiveness ingredient of cosmetic industry have vitamin (containing derivative), coenzyme, peptide, amino acid and
Its derivative, natural organic acids class and each Plant Extracts etc., these both effectiveness crease-resistant mechanism of ingredient are different, but all generally deposit
The problems such as molecular weight is difficult to infiltrate through greatly skin, and crease-resistant efficiency is lower or has skin irritation, reach preferable anti-
Wrinkle effect and to take into account its mildness be the crease-resistant a great problem of cosmetics.
Cataplasm is the external use plaster using water soluble polymer as matrix, with traditional adhesive plaster matrix ratio, tool
The advantages that irritant low, drug inclusion quantity is big, and viscosity can controllably notice repeatedly, low temperature process protection effect ingredient.Make
The both effectiveness ingredient of cosmetics is loaded with cataplasm, on the one hand can reinforce the permeability of both effectiveness ingredient, another aspect cataplasm tool
There is the effect of sustained release, its mildness can be improved while extending both effectiveness ingredient retention time.
Summary of the invention
The technical problem to be solved by the present invention is to, it is good to provide a kind of transdermal characteristic, the low anti-wrinkle composition of irritation and its bar
The preparation method of cloth agent.
In order to solve the above technical problems, the present invention is the following technical schemes are provided: a kind of anti-wrinkle composition, it is characterised in that:
Consist of the following mass percentage components: L-fucose 15-25%, 1,5- dehydration-D- glucitol 15-25%, inositol 10-20%,
Allitol 5-10%, D-Psicose 5-10%, deionized water 20%.
There are German Zhen Li vitamins section in L-fucose of the present invention, CAS:2438-80-4, purity >=95%, commercial product
Skill Co., Ltd.L-fucose can inhibit the generation of metalloproteinases MMP-2 and MMP-9, so that delaying skin is degenerated, while can
The biosynthesis and precipitating of stimulation of elastin increase elastomer density.
1,5- dehydration-D- glucitol of the present invention, CAS:154-58-5, purity >=99%, commercial product have Japan's volt to see
Co., Ltd., pharmacy institute.1,5- dehydration-D- glucitol has good moistening effect, efficiently collagen can be promoted to generate.
Inositol also known as inose of the present invention, CAS:6917-35-7, purity >=98%, commercial product have Japan to build wild rice
Chemical Co., Ltd..Sebum secretion is adjusted in inositol, keeps skin fine and smooth, delaying skin aging.
There are Shanghai Mai Ruier chemical technology in allitol of the present invention, CAS:488-44-8, purity >=98%, commercial product
Co., Ltd, allitol have effects that anti-oxidant, removing free radical.
D-Psicose of the present invention, CAS:551-68-8, purity >=98%, commercial product have Shanghai Mai Ruier chemical
Technology Co., Ltd..D-Psicose can make the obvious water profit of skin, promote cell-cell adhesion, improve barrier function, improve scurf
It falls off, reduces microgroove.
The present invention also provides a kind of preparation methods of anti-wrinkle composition cataplasm, it is characterised in that uses following steps:
A, in mass ratio 15-25: 15-25: 10-20: 5-10: 5-10: 20 to weigh L-fucose, 1,5- respectively de-
Water-D- glucitol, inositol, allitol, D-Psicose, deionized water, stir evenly to obtain anti-wrinkle composition；
B, in mass ratio 0.5-1: 5-10: 60 carbomer, Sodium Polyacrylate, deionized water are weighed respectively, by the card wave
Nurse, Sodium Polyacrylate are sprinkled into the deionized water, are stirred evenly with the revolving speed of 800rpm, as sticker phase；
C, in mass ratio 15: 8: 2-5 glycerol, ethyl alcohol, kaolin are weighed respectively, after mixing, stirred with the revolving speed of 500rpm
Uniformly, as filler phase；
D, in mass ratio 0.5-1: 1 tromethamine and deionized water, mixed dissolution, as crosslinking agent phase are weighed respectively；
E, in mass ratio 5: 60-70: 20-30: 1-2 sticker obtained by anti-wrinkle composition obtained by step A, step B is weighed
Filler phase obtained by phase, step C, crosslinking agent phase obtained by step D, are added to the sticker phase for the anti-wrinkle composition, with
The revolving speed of 800rpm stirs evenly；Then filler phase is added, is stirred evenly with the revolving speed of 800rpm；It is eventually adding crosslinking agent
Phase stirs into uniform thick semi-solid fluid cataplasm lotion with the revolving speed of 1000rpm；Take 10g cataplasm lotion uniform
It is coated on the non-woven fabrics of 3cm × 5cm, is put in 45 DEG C of drying boxes drying 2h, then take out and cover the anti-stick layer of polyethylene and obtain
Anti-wrinkle composition cataplasm.
Carbomer of the present invention is purchased from U.S. Lu Borun, the trade mark are as follows: Carbopol 980；The Sodium Polyacrylate is purchased from
German Corning, the trade mark are as follows: Cosmedia SP；The glycerol is purchased from Malaysian P&G；The 1,3 butylene glycol is purchased from association, Japan
With；The ethyl alcohol is purchased from Anhui An Te；The kaolin is purchased from China Kaolin Co., Ltd, the trade mark are as follows: DB-1；The tromethamine
Purchased from ANGUS Chemical Company.
The non-woven fabrics and the anti-stick layer of polyethylene are purchased from Shanghai Pharmaceutical Technology Co., Ltd, Youjie.
The drying box model are as follows: DZF-1 type vertical vacuum drying box, manufacturer are Beijing Lin Mao scientific & technical corporation；
L-fucose, 1,5- dehydration-D- glucitol, the inositol, allitol, D-Psicose group of present invention selection extra fine quality ratio
At anti-wrinkle composition, molecular weight is respectively less than 200, has good transdermal characteristic；And skin-friendly is good, does not stimulate mildly；Have simultaneously
Have and promotes elastin laminin and collagen synthesis, free radical resisting, promote intercellular adhesion, rebuild skin barrier, adjust skin water
It is crease-resistant to have reached preferable skin from different mechanism, synergistic effect for oil balance, efficient replenishing water and preserving moisture and other effects, composition
Effect.
For cataplasm of the present invention using high molecular polymer as matrix, mildness is good, helps when use to open pore,
Promote the osmotic absorption of both effectiveness ingredient.Cataplasm of the invention simultaneously has slow release effect, can extend releasing for both effectiveness ingredient
The time is put, the amount that skin in the same time touches the effect of property ingredient is reduced, it is ensured that is both effectiveness stable components, mild, efficiently
Ground plays a role.Cataplasm size 3cm × 5cm prepared by the present invention is suitable for forehead, canthus, cheek, neck etc. everywhere easily
Generate the position of wrinkle.
For confirmation effect of the present invention, following experiment has been carried out:
The mildness verifying for having effects that crease-resistant cataplasm prepared by experiment one, the present invention
The cataplasm lotion for being not applied at non-woven fabrics prepared by Example 1 is diluted to the aqueous solution that mass concentration is 10%, into
There is not any exception in the experiment of row chick chorioallantoic membrane, chick chorioallantoic membrane.Chick chorioallantoic membrane description of test system of the present invention
Standby cataplasm lotion irritation is very low.
100 volunteers are chosen, the age is not applied at nonwoven between 30-50 years old, using prepared by the embodiment of the present invention 1
The cataplasm lotion of cloth, volunteer's back carry out patch test, for 24 hours afterwards tear off patch test chip, respectively after removing 1h,
2h, skin condition at test is observed for 24 hours, as a result such as table 1:
1 human body patch test experimental result of table
In table 1 statistics indicate that, in 100 volunteers only have 1 after tearing patch test chip 1h skin exist slightly it is rubescent
Phenomenon, and taken off in 2h after removing, illustrate that cataplasm lotion prepared by the present invention does not stimulate mildly.
Has effects that crease-resistant cataplasm the effect of property verifying prepared by experiment two, the present invention
100 volunteers are chosen, the age is between 30-50 years old, it is desirable that volunteer is prepared in left face using embodiment 1 sooner or later daily
The cataplasm containing anti-wrinkle composition twice, each 30min, and above-mentioned anti-aging is not added in right face use with similarity condition
The cataplasm of composition is as blank control group.Using preceding and follow-up when using 1 week, 2 weeks, 4 weeks, follow up time is same in the daytime
Time, subject need to sit quietly 20min under constant temperature and humidity (22 ± 2 DEG C of room temperature, relative humidity 45 ± 5%) environment before testing, then
Using CM825 skin moisture tester, MPA580 skin elasticity tester and PROMOS PICO wrinkle of skin detector to tested
Person's left and right face is detected and analyzed.Table 2 is 100 volunteer's different time nodes, left and right face moisture measurement result average value.
2 skin moisture test result of table
Table 2 be use before, using after 1 week, using after 2 weeks, using CM825 skin moisture tester test statistics after 4 weeks as a result,
Numerical value is bigger, and keratoderma moisture content is higher, and the result from table 2 is but left it is found that both sides face moisture content is all gradually incremented by
The skin moisture of face embodiment is all significantly greater than the control group of right face containing numerical quantity and growth rate.Illustrate to use and contains crease-resistant group
The cataplasm for closing object can promote keratoderma moisture content, make skin is full not dry.
3 elasticity of skin test result of table
Table 3 be use before, using after 1 week, use after 2 weeks, using after 4 weeks MPA580 skin elasticity tester test R2 and R5
Statistical data, by table 3 as it can be seen that be all larger than the blank control group of right face using R2, R5 value of face embodiment left from 1 week, and more
Close to 1, illustrate effectively promote skin elasticity using the cataplasm containing anti-wrinkle composition.
4 skin wrinkle test result of table
Table 4 be use before, using after 1 week, use after 2 weeks, using after 4 weeks PROMOS PICO wrinkle of skin detector test
Statistical data (average values of 100 people), wherein Sa, Sq, Sk, Sv, Wd are the wrinkle depth factor, for characterizing the wrinkle depth, Sa,
Sq, Sk, Wd and wrinkle depth are positively correlated, and Sv and wrinkle depth are negatively correlated；AWa, pWa are wrinkle area factor, with wrinkle area
It is positively correlated；Wv is wrinkle severity multi-stress, is positively correlated with wrinkle severity.It can be obtained by data in table 4, use is crease-resistant
Each wrinkle of the left face embodiment of composition is positively correlated the factor with using the time decreased significantly, and the wrinkle negative correlation factor is then with making
There is obvious rising with the time, and each data of the right face of blank control group only have minor change.Therefore it can illustrate using containing crease-resistant combination
The cataplasm of object can obviously reduce wrinkle of skin.
The percutaneous absorbability verifying for having effects that crease-resistant cataplasm prepared by experiment three, the present invention
Experiment uses the Franz diffusion cell method of vertical-type, and BaMa miniature pig skin is selected (to research and develop purchased from Chongqing ancestor Shen doctor up to biotechnology
Co., Ltd) it is used as in vitro transdermal experiment skin, select deionized water as receiving liquid, magnetic stirring speed 200rpm connects
Receive 37 ± 0.5 DEG C of room constant temperature.With 10g cataplasm (active component content 4%) prepared by embodiment 1 for experimental group A, 10g 4%
The aqueous solution that the example 1 group of active constituent closes object is experimental group B, and 10g 4% commonly uses crease-resistant functional component Argireline
(being purchased from Nanjing Lai Ang Biotechnology Co., Ltd) aqueous solution is experimental group C, and the percentage that this experiment refers to is mass ratio.Often
Every 5min by each component content in efficient liquid phase chromatographic analysis receiving liquid, transdermal absorption factor is calculated.Every group of experiment carries out three times,
It is averaged, experimental result such as table 5:
5 Transdermal absorption experimental data of table
Statistics indicate that, experimental group A and B transdermal absorption factor illustrate to resist prepared by the present invention obviously higher than experimental group C in table 5
Wrinkle composition transdermal absorption factor is apparently higher than Argireline；Experimental group B transdermal absorption factor early period is fast but the later period increases seldom,
Experimental group A Transdermal absorption is slow compared with experimental group B, but transdermal absorption factor improves continuously and healthily, and when 25min has been more than experimental group B, explanation
Cataplasm prepared by the present invention has good slow releasing function, and can promote the Transdermal absorption of both effectiveness ingredient.
In summary the data tested, anti-wrinkle composition and its cataplasm prepared by the present invention have good transdermal characteristic, low
Irritation and good crease-resistant effect.
Specific embodiment
Technical solution of the present invention is described further by the following examples, but protection scope of the present invention and unlimited
In this.
Embodiment 1: a kind of preparation method of anti-wrinkle composition cataplasm:
A, in mass ratio 20: 20: 20: 10: 10: 20 weigh respectively L-fucose, 1,5- dehydration-D- glucitol,
Inositol, allitol, D-Psicose, deionized water stir evenly to obtain anti-wrinkle composition；
B, in mass ratio 1: 5: 60 carbomer, Sodium Polyacrylate, deionized water are weighed respectively, successively by the weighed card wave of institute
Nurse, Sodium Polyacrylate be sprinkled into be dispersed with stirring uniformly using the mixing speed of 800rpm as sticker in weighed deionized water
Phase；
C, in mass ratio 15: 8: 4 glycerol, ethyl alcohol, kaolin mixing are weighed respectively, with the mixing speed stirring point of 500rpm
It dissipates and is uniformly used as filler phase；
D, in mass ratio 1: 1 tromethamine and deionized water mixed dissolution are weighed respectively as crosslinking agent phase；
E, in mass ratio 5: 66: 27: 2 weigh respectively filler phase described in sticker phase, C described in composition, B described in A,
Anti-wrinkle composition is added to sticker phase, is dispersed with stirring uniformly with the mixing speed of 800rpm by crosslinking agent phase described in D；It is added
Filler phase is dispersed with stirring uniformly with the mixing speed of 800rpm；Crosslinking agent phase is added, is stirred with the mixing speed of 1000rpm
Uniformly at thick semi-solid fluid cataplasm lotion, takes 10g lotion to be spread evenly across on the non-woven fabrics of 3cm × 5cm immediately, put
2h is baked in 45 DEG C of drying boxes, the anti-stick layer of polyethylene is covered after taking-up and obtains cataplasm.
Embodiment 2: a kind of preparation method of anti-wrinkle composition cataplasm:
A, in mass ratio 25: 25: 10: 10: 10: 20 weigh respectively L-fucose, 1,5- dehydration-D- glucitol,
Inositol, allitol, D-Psicose, deionized water stir evenly to obtain anti-wrinkle composition；
B, in mass ratio 0.5: 5: 60 carbomer, Sodium Polyacrylate, deionized water are weighed respectively, successively by the weighed card of institute
Wave nurse, Sodium Polyacrylate be sprinkled into be dispersed with stirring uniformly using the mixing speed of 800rpm as sticker in weighed deionized water
Phase；
C, in mass ratio 15: 8: 5 glycerol, ethyl alcohol, kaolin mixing are weighed respectively, with the mixing speed stirring point of 500rpm
It dissipates and is uniformly used as filler phase；
D, in mass ratio 0.5: 1 tromethamine and deionized water mixed dissolution are weighed respectively as crosslinking agent phase；
E, in mass ratio 5: 65.5: 28: 1.5 filling described in sticker phase, C described in composition, B described in A is weighed respectively
Anti-wrinkle composition is added to sticker phase, is dispersed with stirring uniformly with the mixing speed of 800rpm by crosslinking agent phase described in agent phase, D；
Filler phase is added, is dispersed with stirring uniformly with the mixing speed of 800rpm；Crosslinking agent phase is added, with the mixing speed of 1000rpm
It is stirred into thick semi-solid fluid cataplasm lotion, 10g lotion is taken to be spread evenly across the non-woven fabrics of 3cm × 5cm immediately
On, it is put in 45 DEG C of drying boxes and bakes 2h, the anti-stick layer of polyethylene is covered after taking-up and obtains cataplasm.
Embodiment 3: a kind of preparation method of anti-wrinkle composition cataplasm:
A, in mass ratio 25: 25: 15: 5: 10: 20 L-fucose, 1,5- dehydration-D- glucitol, flesh are weighed respectively
Alcohol, allitol, D-Psicose, deionized water stir evenly to obtain anti-wrinkle composition；
B, in mass ratio 0.8: 5: 60 carbomer, Sodium Polyacrylate, deionized water are weighed respectively, successively by the weighed card of institute
Wave nurse, Sodium Polyacrylate be sprinkled into be dispersed with stirring uniformly using the mixing speed of 800rpm as sticker in weighed deionized water
Phase；
C, in mass ratio 15: 8: 4.4 glycerol, ethyl alcohol, kaolin mixing are weighed respectively, stirred with the mixing speed of 500rpm
It is uniformly dispersed as filler phase；
D, in mass ratio 0.8: 1 tromethamine and deionized water mixed dissolution are weighed respectively as crosslinking agent phase；
E, it in mass ratio 5: 65.8: 27.4: 1.8 weighs filled out described in sticker phase, C described in composition, B described in A respectively
Crosslinking agent phase described in agent phase, D is filled, anti-wrinkle composition is added to sticker phase, is dispersed with stirring with the mixing speed of 800rpm
It is even；Filler phase is added, is dispersed with stirring uniformly with the mixing speed of 800rpm；Crosslinking agent phase is added, with the stirring speed of 1000rpm
Degree is stirred into thick semi-solid fluid cataplasm lotion, and 10g lotion is taken to be spread evenly across the nonwoven of 3cm × 5cm immediately
On cloth, it is put in 45 DEG C of drying boxes and bakes 2h, the anti-stick layer of polyethylene is covered after taking-up and obtains cataplasm.
Embodiment 4: a kind of preparation method of anti-wrinkle composition cataplasm:
A, in mass ratio 23: 22: 20: 5: 10: 20 L-fucose, 1,5- dehydration-D- glucitol, flesh are weighed respectively
Alcohol, allitol, D-Psicose, deionized water stir evenly to obtain anti-wrinkle composition；
B, in mass ratio 1: 7: 60 carbomer, Sodium Polyacrylate, deionized water are weighed respectively, successively by the weighed card wave of institute
Nurse, Sodium Polyacrylate be sprinkled into be dispersed with stirring uniformly using the mixing speed of 800rpm as sticker in weighed deionized water
Phase；
C, in mass ratio 15: 8: 2 glycerol, ethyl alcohol, kaolin mixing are weighed respectively, with the mixing speed stirring point of 500rpm
It dissipates and is uniformly used as filler phase；
D, in mass ratio 1: 1 tromethamine and deionized water mixed dissolution are weighed respectively as crosslinking agent phase；
E, in mass ratio 5: 68: 25: 2 weigh respectively filler phase described in sticker phase, C described in composition, B described in A,
Anti-wrinkle composition is added to sticker phase, is dispersed with stirring uniformly with the mixing speed of 800rpm by crosslinking agent phase described in D；It is added
Filler phase is dispersed with stirring uniformly with the mixing speed of 800rpm；Crosslinking agent phase is added, is stirred with the mixing speed of 1000rpm
Uniformly at thick semi-solid fluid cataplasm lotion, takes 10g lotion to be spread evenly across on the non-woven fabrics of 3cm × 5cm immediately, put
2h is baked in 45 DEG C of drying boxes, the anti-stick layer of polyethylene is covered after taking-up and obtains cataplasm.
Embodiment 5: a kind of preparation method of anti-wrinkle composition cataplasm:
A, in mass ratio 21: 24: 20: 5: 10: 20 L-fucose, 1,5- dehydration-D- glucitol, flesh are weighed respectively
Alcohol, allitol, D-Psicose, deionized water stir evenly to obtain anti-wrinkle composition；
B, in mass ratio 0.5: 6: 60 carbomer, Sodium Polyacrylate, deionized water are weighed respectively, successively by the weighed card of institute
Wave nurse, Sodium Polyacrylate be sprinkled into be dispersed with stirring uniformly using the mixing speed of 800rpm as sticker in weighed deionized water
Phase；
C, in mass ratio 15: 8: 4 glycerol, ethyl alcohol, kaolin mixing are weighed respectively, with the mixing speed stirring point of 500rpm
It dissipates and is uniformly used as filler phase；
D, in mass ratio 0.5: 1 tromethamine and deionized water mixed dissolution are weighed respectively as crosslinking agent phase；
E, in mass ratio 5: 66.5: 27: 1.5 filling described in sticker phase, C described in composition, B described in A is weighed respectively
Anti-wrinkle composition is added to sticker phase, is dispersed with stirring uniformly with the mixing speed of 800rpm by crosslinking agent phase described in agent phase, D；
Filler phase is added, is dispersed with stirring uniformly with the mixing speed of 800rpm；Crosslinking agent phase is added, with the mixing speed of 1000rpm
It is stirred into thick semi-solid fluid cataplasm lotion, 10g lotion is taken to be spread evenly across the non-woven fabrics of 3cm × 5cm immediately
On, it is put in 45 DEG C of drying boxes and bakes 2h, the anti-stick layer of polyethylene is covered after taking-up and obtains cataplasm.
Claims (2)
1. a kind of anti-wrinkle composition, it is characterised in that: consist of the following mass percentage components: L-fucose 15-25%, 1,
5- dehydration-D- glucitol 15-25%, inositol 10-20%, allitol 5-10%, D-Psicose 5-10%, deionized water 20%.
2. a kind of preparation method of anti-wrinkle composition cataplasm, it is characterised in that use following steps:
A, in mass ratio 15-25: 15-25: 10-20: 5-10: 5-10: 20 to weigh L-fucose, 1,5- respectively de-
Water-D- glucitol, inositol, allitol, D-Psicose, deionized water, stir evenly to obtain anti-wrinkle composition；
B, in mass ratio 0.5-1: 5-10: 60 carbomer, Sodium Polyacrylate, deionized water are weighed respectively, by the card wave
Nurse, Sodium Polyacrylate are sprinkled into the deionized water, are stirred evenly with the revolving speed of 800rpm, as sticker phase；
C, in mass ratio 15: 8: 2-5 glycerol, ethyl alcohol, kaolin are weighed respectively, after mixing, stirred with the revolving speed of 500rpm
Uniformly, as filler phase；
D, in mass ratio 0.5-1: 1 tromethamine and deionized water, mixed dissolution, as crosslinking agent phase are weighed respectively；
E, in mass ratio 5: 60-70: 20-30: 1-2 sticker obtained by anti-wrinkle composition obtained by step A, step B is weighed
Filler phase obtained by phase, step C, crosslinking agent phase obtained by step D, are added to the sticker phase for the anti-wrinkle composition, with
The revolving speed of 800rpm stirs evenly；Then filler phase is added, is stirred evenly with the revolving speed of 800rpm；It is eventually adding crosslinking agent
Phase stirs into uniform thick semi-solid fluid cataplasm lotion with the revolving speed of 1000rpm；Take 10g cataplasm lotion uniform
It is coated on the non-woven fabrics of 3cm × 5cm, is put in 45 DEG C of drying boxes drying 2h, then take out and cover the anti-stick layer of polyethylene and obtain
Anti-wrinkle composition cataplasm.
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Application publication date: 20190329 |