CN107550847A - A kind of active skincare composition and its application - Google Patents
A kind of active skincare composition and its application Download PDFInfo
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Abstract
The present invention relates to a kind of active skincare composition and its application, described skin care compositions includes the component of following portions by weight：1~10 part of 1~10 part of natural pigment alcohol plastid, 0.05~4 part of enoxolone, 0.05~2 part of palmatine, 0.1~1 part of cysteinyl glycine, 0.1~1 part of L Vitamin C acyls palmitate, 0.01~1 part of shellolic acid and mountain region rose callus cell suspending nutrient solution freeze-dried powder.Described active skincare composition makes every effort to make natural component and skin intimate contact, reach the double effectses for beautifying reason in outer flesh and regulation, meet the joint demand of the different skin forms such as net white, anti-anaphylaxis, oil-control, anti-ageing, tender skin, allow skin care that admiring effect can be presented immediately.
Description
Technical field
The present invention relates to cosmetic technical field, and in particular to a kind of active skincare composition and its application.
Background technology
Ultraviolet can promote skin aging to obtain the common recognition of people, and excessive ultraviolet irradiates the elasticity that can destroy corium
Fiber and collagen fabric, are broken fibre modification, so as to cause cutis laxa, wrinkle occur.Meanwhile ultraviolet can also machine
Body release activation melanin forms signal, produces excessive melanin, causes skin pigmentation occur, forms color spot, and companion
There is the disappearance of skin gloss, become obscure.At the same time, destruction of the ultraviolet to keratoderma, epidermis and dermal cell are promoted
Free radical caused by metabolism, free radical are that body produces oxidation " arch-criminal ", are destroyed cellulose, cause moisture
Loss, moisture, which is largely lost in, causes skin to secrete more greases, makes the dirts such as dust be more difficult to wash off, can lead in the course of time
Cause the colour of skin dark yellow, blackhead, the problems such as pachylosis.
At present, skin care item a great variety on the market, but quality is uneven, it is not that effect is also presented the good and the bad, effect list
One, lay particular emphasis on moisturizing and lay particular emphasis on whitening spot-removing and lay particular emphasis on anti-aging or lay particular emphasis on wrinkle.And one
A little products also containing compositions such as lead, mercury, hormones, can not only play a part of skin care, on the contrary serious threat skin health,
Also some skin care item water contents are larger, or containing alkalescent composition, being contacted for a long time with skin can be because excessive infiltration causes
Skin edema and allergic phenomena, therefore, the deep trust by consumers in general of pure natural skin care item and like at present.
" one kind has reparative regeneration, replenishing water and preserving moisture, delays to decline the B of Publication No. CN 104758222 Chinese patent application
Old cosmetics " include Rhizoma Atractylodis Macrocephalae extract, Radix Ampelopsis extract, angelica extract, apricot seed extract, dendrobium candidum extract,
Aloe extract, chaste tree silkworm powder and bletilla striata powder, there is whitening spot-removing, anti-anaphylaxis antiallergic, delay cell senescence.
A kind of and for example B of Publication No. CN 104622776 Chinese patent application " cosmetic combinations containing Chinese medicine extract
Thing " formula is by ginseng, Radix Angelicae Sinensis, lanatechead saussurea herb with flower, folium artemisiae argyi, pseudo-ginseng, frankincense, eupatorium, radix pseudostellariae, hairyvein agrimony, radix polygonati officinalis, pilose antler, rough gentian, pungent
Sprout, Selaginella tamariscina, tree peony, Chinese herbaceous peony, centella, Pogostemon cablin, Ligusticum wallichii, Poria cocos, the banksia rose, yellow chamomile, matrimony vine composition, have good whitening
Nti-freckle, tender skin go effect of wrinkling.
However, containing the traditional Chinese medicine ingredients compared with multiple types in above-mentioned skin care compositions, considerably increase between compounding
Difficulty, it is difficult to ensure that skin-protection product keeps good stability during long-term use, it is therefore necessary to provide a kind of quality
Stable, the significant natural plant sun skin-protection product of skin effect.
The content of the invention
To solve the problems, such as that prior art is present, it is an object of the invention to provide a kind of active skincare composition and its answer
Stable, safe and non-stimulating, the gentle pro-skin with, the skin care compositions property, not only has a preferable sun-proof performance, and to solarization after
Damage is as dried, decortication and redness are respectively provided with good repair, and moisturizing Shu Min, whitening spot-removing significant effect, to prolonging
Slow aging tool has certain effect.
Technical scheme is as follows：
A kind of active skincare composition, it is characterised in that described skin care compositions includes the component of following portions by weight：
1~10 part of natural pigment alcohol plastid, 0.05~4 part of enoxolone, 0.05~2 part of palmatine, the sweet ammonia of cysteinyl
Sour 0.1~1 part, 0.1~1 part of L- Vitamin C acyls palmitate.
Preferably, described skin care compositions also includes 0.01~1 part of shellolic acid.
Preferably, described skin care compositions also include mountain region rose callus cell suspending nutrient solution freeze-dried powder 1~
10 parts.
It is highly preferred that described skin care compositions includes the component of following portions by weight：
5~8 parts of natural pigment alcohol plastid, 1~2 part of enoxolone, 0.1~1 part of palmatine, cysteinyl glycine 0.5
~1 part, 0.5~1 part of L- Vitamin C acyls palmitate, 0.1~0.5 part of shellolic acid, mountain region rose callus cell suspend training
6~10 parts of nutrient solution freeze-dried powder.
Further, described natural pigment alcohol plastid includes the component of following portions by weight：0.1~1 part of natural pigment,
4~12 parts of soybean lecithin, 20~30 parts of ethanol, 1~2 part of polyethylene glycol stearate, 3~5 parts of hydroxyethyl piperazineethanesulfonic acid
With 20~30 parts of deionized water.
Preferably, described natural pigment alcohol plastid includes the component of following portions by weight：0.8 part of natural pigment, soybean
25 parts of 8 parts of lecithin, 30 parts of ethanol, 2 parts of polyethylene glycol stearate, 5 parts of hydroxyethyl piperazineethanesulfonic acid and deionized water.
Further, described natural pigment by chlorophyll and lycopene with 1:0.1~1 mass ratio composition.
Preferably, described natural pigment by chlorophyll and lycopene with 1:0.6 mass ratio composition.
In active skincare composition of the present invention, chlorophyll and lycopene are natural fat-soluble pigment, have light
Absorbent properties, both have preferable synergistic function at the absorption to ultraviolet.However, often stability is very for natural pigment
Difference, and be difficult to be dissolved in water, its use is greatly limit, and itself carries certain color, pigment is dfficult to apply to skin care
The preparation of product.Creatively alcohol plastid is made in chlorophyll and lycopene by the present invention, will using alcohol plastid bilayer structure
Chlorophyll and lycopene greatly improve both solubility properties and stability, avoid extraneous factor green to leaf in being coated on
The degradation of element and lycopene, make so as to give full play to the absorption of chlorophyll and lycopene to visible ray and ultraviolet
With so as to obtain preferable sun-proof result.Meanwhile alcohol plastid is easily deformable and penetrate skin barrier, promote Transdermal absorption, enhancing
Chlorophyll and lycopene enter the ability of cell, and give full play to removing free radical, anti-oxidant, anti-aging, improve immune
The effect of power.
Specifically, the preparation of described natural pigment alcohol plastid comprises the following steps：
Soybean lecithin is weighed, is dissolved with ethanol, then adds polyethylene glycol stearate, natural pigment, is well mixed；
In 400r.min-1Under conditions of, with peristaltic pump with 100 μ L.min-1Speed will the hydroxyethyl piperazineethanesulfonic acid that dissolve in advance
In aqueous solution injection ethanol solution, injection finishes, 10000r.min-1Stirring 2min makes its homogenization, then the micropore for passing through 200nm
Homogeneous film process, alcohol plastid liquid is obtained, cool and solidify, produce natural pigment alcohol plastid.
In above-mentioned natural pigment alcohol plastid preparation technology, polyethylene glycol stearate is containing hydroxyethyl piperazineethanesulfonic acid
Under buffer condition, alcohol plastid can be promoted to form complete, uniform similar round vesica, reduce the particle diameter of alcohol plastid, improve chlorophyll
With the envelop rate of lycopene.
Further, the present invention also provides a kind of described mountain region rose callus cell suspending nutrient solution freeze-dried powder
Preparation technology, it comprises the following steps：
(1) sterile mountain region Rose leaf is taken to be inoculated in MS+0.8~1.2mg/L 6-BA+1.2~2.0mg/L 2,4-D+
Callus induction is carried out in the solid medium of 4g/L agar+25g/L sucrose, the squamous subculture time is 105~120 days, choosing
Take the callus of the loose ivory buff of continuous subculture 3 times；
(2) the loose ivory buff callus for taking step (1) to obtain, it is big to be divided into mung bean with sterilized tweezers
It is small, it is seeded to 1/2MS+1.5 containing 40ml~2.0mg/L 6-BA+0.5~1.0mg/L 2,4-D+30g/L sucrose, pH 5.8
Fluid nutrient medium 100ml conical flasks in, on 25 DEG C of constant-temperature table, 100rpm, carry out under the conditions of 12h/d light application times
Suspend culture, after cultivating 15d, filtrate is taken after being sieved through filter with 50 aim cells, filtrate is sieved through filter with 80 aim cells again, takes filter
Liquid, sterilizing are lyophilized to produce.
In addition, the present invention also provides a kind of above-mentioned active skincare composition has sun-proof reparation work(in preparation
Application in energy, delay skin aging, whitening spot-removing skin care item or cosmetics.
Active skincare composition of the present invention is by the alcohol plastid containing chlorophyll and lycopene, enoxolone, palmatine, half Guang
Aminoacyl glycine and L- Vitamin C acyl palmitates rationally compound, and each component synergy, can effectively absorb ultraviolet and removing
Free radical, damaging action of the ultraviolet to skin is prevented, mitigate ultraviolet and promote apoptosis of fibroblasts, delaying skin light aging is made
With, while the breeding of melanocyte can also be delayed, suppress the generation of melanin, there is the effect of whitening spot-removing.
Active skincare composition provided by the invention is also containing shellolic acid, mountain region rose callus cell suspending nutrient solution
One or two kinds of combinations of freeze-dried powder, both the above component mutually cooperate with other components of the present invention, promote elastomer and glue
Former azelon reparation, has repair to actinic damage.Wherein, shellolic acid can stimulate circulation, Cucumber Extract, improve
The colour of skin, make skin keep gloss, in addition, shellolic acid interacts with L- Vitamin C acyls palmitate, substantially increase natural colour
The stability of plain alcohol plastid, the shin moisturizer containing natural pigment alcohol plastid is set to keep good dispersed during long-term use
State, prevent chlorophyll and lycopene to be demulsified and separate out, form precipitation.Mountain region rose callus cell suspending nutrient solution freeze-dried powder
The synthesis of collagen and hyaluronic acid can be promoted, improve the hydrauture of skin, make skin that there is good moistening effect, compact
Skin, and can be to immunosupress caused by IL-10 expression increase caused by ultraviolet light, skin DNA after excited ultraviolet irradiation
Naturally matrix is repaired, promotes DNA of the cell after by ultraviolet irradiation infringement to synthesize, hence it is evident that to reduce solarization of the cell by induced by ultraviolet irradiation
Wound, delay skin aging process.
Compared with prior art, advantage of the invention is that：
(1) active skincare composition property provided by the invention is stable, adds it in skin care item or cosmetics, can send out
Wave moisturizing, antiallergic, remove wrinkle, anti-oxidant, whitening spot-removing and other effects, especially there is obvious defence to light aging caused by ultraviolet
Effect, there is significant repair to damage after solarization.
(2) active skincare composition provided by the invention makes every effort to make natural component and skin intimate contact, and it is outer to reach beautification
The double effectses of reason in flesh and regulation, meet the joint demand of the different skin forms such as net white, anti-anaphylaxis, oil-control, anti-ageing, tender skin,
Allow skin care that admiring effect can be presented immediately.
Embodiment
The present invention is further described below by way of embodiment, but the present invention is not limited only to following examples.
The preparation of the natural pigment alcohol plastid of embodiment 1
The preparation of A group natural pigment alcohol plastids：
Soybean lecithin is weighed, is dissolved with ethanol, then adds polyethylene glycol stearate, natural pigment, is well mixed；
In 400r.min-1Under conditions of, with peristaltic pump with 100 μ L.min-1Speed will the hydroxyethyl piperazineethanesulfonic acid that dissolve in advance
In aqueous solution injection ethanol solution, injection finishes, 10000r.min-1Stirring 2min makes its homogenization, then the micropore for passing through 200nm
Homogeneous film process, alcohol plastid liquid is obtained, cool and solidify, produce natural pigment alcohol plastid.
The preparation process of B-E group natural pigment alcohol plastids is with reference to shown in above-mentioned A groups.
The particle diameter of natural pigment alcohol plastid made from above-mentioned A-E groups and envelop rate are detected respectively, as a result see the table below 1 institute
Show：
The natural pigment alcohol plastid quality measurements of table 1
| Group | Particle diameter/nm | Envelop rate/% |
| A groups | 175.0 | 99.32 |
| B groups | 172.8 | 99.45 |
| C groups | 190.4 | 89.54 |
| D groups | 194.6 | 82.17 |
| E groups | 199.5 | 70.62 |
As seen from the above table, alcohol plastid adds a certain amount of polyethylene glycol stearate and ethoxy piperazine in preparation process
Piperazine ethyl sulfonic acid, the relatively small similar round vesica of particle diameter can be effectively formed, and significantly improve the encapsulating of chlorophyll and lycopene
Rate, make envelop rate up to more than 99%.
The preparation of the mountain region rose callus cell suspending nutrient solution freeze-dried powder of embodiment 2
(1) take sterile mountain region Rose leaf be inoculated in MS+0.8mg/L 6-BA+1.2mg/L 2,4-D+4g/L agar+
Carry out callus induction in the solid medium of 25g/L sucrose, the squamous subculture time is 105 days, chooses continuous subculture 3 times
The callus of loose ivory buff；
(2) the loose ivory buff callus for taking step (1) to obtain, it is big to be divided into mung bean with sterilized tweezers
It is small, the 6-BA+0.6mg/L of 1/2MS+2.0mg/L containing 40ml 2,4-D+30g/L sucrose are seeded to, pH is 5.8 Liquid Culture
In the 100ml conical flasks of base, on 25 DEG C of constant-temperature table, 100rpm, suspension culture is carried out under the conditions of 12h/d light application times,
After cultivating 15d, filtrate is taken after being sieved through filter with 50 aim cells, filtrate is sieved through filter with 80 aim cells again, takes filtrate, sterilizes, and freezes
It is dry to produce.
Embodiment 3-4 and comparative example 1-4 shin moisturizer preparation
The preparation of shin moisturizer, wherein embodiment are carried out using active skincare composition provided by the invention as primary raw material
3-4 and comparative example 1-4 shin moisturizer include the preparing raw material of parts by weight meter shown in following table, wherein mountain region rose callus cell
Suspending nutrient solution freeze-dried powder is prepared by embodiment 2.
The preparation of the shin moisturizer of embodiment 3：
Take palmatine, shellolic acid to be dissolved in water, heat while stirring, until both are completely dissolved, be cooled to room temperature, add successively
Enter Sensiva SC50, L- Vitamin C acyls palmitate, cysteinyl glycine, enoxolone, natural pigment alcohol plastid and mountain
Ground rose callus cell suspending nutrient solution freeze-dried powder, stirs, and progress is filling, produces.
The preparation of embodiment 4 and comparative example 1-4 shin moisturizer refers to above-mentioned method.
The preparation of the suncream of embodiment 5
The preparation of the suncream of embodiment 5：
(1) octadecyl alcolol, polyoxyethylene 20 sorbitan monooleate, glycerin monostearate, lanolin, ethylhexyl are taken
Glycerine mixes, and is heated to 65 DEG C, stirring and dissolving, as A phases；
(2) take palmatine, shellolic acid to be dissolved in water, heat while stirring, until both are completely dissolved, be cooled to room temperature, according to
Secondary addition L- Vitamin C acyls palmitate, cysteinyl glycine, enoxolone, natural pigment alcohol plastid and mountain region rose callus
Histocyte suspending nutrient solution freeze-dried powder, stirs, as B phases；
(3) B phases are slowly added into A phases, after stirring, discharging, produced.
Test example one, human skin patch
With reference to 2015 editions of Ministry of Public Health's issue《Cosmetics health specification》In " human skin patch " related request
With assay method to shin moisturizer made from 3-4 of the embodiment of the present invention, comparative example 1-4, and suncream made from embodiment 5 is carried out
Test, dermoreaction is observed in 0h, 6h, 12h, 24h, 48h respectively, the experimental result of all trial volunteers is negative knot
Fruit, do not occur skin adverse reaction.Show that shin moisturizer or suncream provided by the invention are nonirritant, it is safe.
Test example two, stability test
(1) accelerated test：3-4 of the embodiment of the present invention, comparative example 1-4 obtained shin moisturizer are taken, carries out high and low temperature storage
Stability test is investigated, experimental condition：1) thimble test：Placed 1 week in 45 DEG C of electro-heating standing-temperature cultivators, recovery room
Observed after temperature；2) low-temperature stability is tested：Deposited 1 week at 2 DEG C, observe its stability, it is as a result as shown in table 1 below.
The each group shin moisturizer accelerated test Detection of Stability result of table 1
From upper table 1, L- Vitamin C acyl palmitates and shellolic acid have important influence to the stability of shin moisturizer,
Both interactions, are greatly improved stability of the natural pigment alcohol plastid in water system, avoid the alcohol plastid containing natural pigment
Shin moisturizer occurs that demulsifying phenomenon occurs under conditions of high temperature and low temperature, causes chlorophyll and lycopene to separate out, forms precipitation.
(2) normal temperature long term test：3-4 of the embodiment of the present invention, comparative example 1-4 obtained shin moisturizer are taken, carries out normal temperature storage
Deposit stability test investigation, experimental condition：23~28 DEG C are placed at, relative humidity is 30~60%, observes its stability, as a result
It is as shown in table 2 below.
The each group shin moisturizer normal temperature long term test Detection of Stability result of table 2
From upper table 2, L- Vitamin C acyl palmitates and shellolic acid have important to the long-time stability of shin moisturizer
Effect, both interact, and greatly improve the bin stability of shin moisturizer, extend the term of validity that shin moisturizer uses.
Test example three, the test of ultraviolet protection performance
Ultraviolet protection performance detection, tool are carried out to shin moisturizer made from 3-4 of the embodiment of the present invention, comparative example 1-4 respectively
Body reference QB/T 2410-1998 (《The evaluation method ultraviolet absorptivity method of sun care preparations UVB areas sun-proof result》) surveyed
It is fixed, absorbance of the measure product between 280~400nm of wavelength, and respectively according to the following formula 1 and formula 2 try to achieve UVB, UVA area wavelength
The average value of lower absorbance A, is designated as A respectivelyUVBAnd AUVA, the results are shown in Table 3.
280~320nm of UVB areas:AUVB=(A280+A290+A300+A310+A320The formula of)/5 (1)
330~400nm of UVA areas:AUVA=(A330+A340+A350+A360+A370+A380+A390+A400The formula of)/8 (2)
The ultraviolet radiation protective effect testing result of each group shin moisturizer of table 3
| Absorbance | Embodiment 3 | Embodiment 4 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| AUVB | 1.874 | 1.820 | 0.952 | 1.474 | 0.765 | 1.358 |
| AUVA | 1.758 | 1.716 | 0.840 | 1.322 | 0.547 | 1.146 |
Note：0.5 ＜ AUVB/AUVA＜ 1.0：Minimum ultraviolet protection；1.1 ＜ AUVB/AUVA＜ 1.5：Medium ultraviolet protection；1.6
＜ AUVB＜ 2.0：Effective UV protects.
From upper table 3, shin moisturizer each component provided by the invention is mutually coordinated, interaction, has efficient ultraviolet
Line protective action.Natural pigment alcohol plastid is free of lycopene in comparative example 1, and ultraviolet protection effect is remarkably decreased, and shows that leaf is green
The interaction of element and lycopene, it is greatly improved the protection effect of ultraviolet.Comparative example 2 is free of shellolic acid and comparative example 3
Ultraviolet protection effect is remarkably decreased without shin moisturizer made from L- Vitamin C acyl palmitates and shellolic acid, shows natural colour
Plain alcohol plastid bad stability, which plays shin moisturizer ultraviolet protection effect, has important influence.Comparative example 4 is free of mountain region rose
Rare callus cell suspending nutrient solution freeze-dried powder, ultraviolet protection effect are decreased obviously, and show mountain region rose callus cell
Suspending nutrient solution freeze-dried powder can improve the ultraviolet radiation protective effect of shin moisturizer to a certain extent.
Test example four, Oxidation Resistance Test
Free radical is that a kind of property is active, has a chemical substance of extremely strong oxidability, in body it is caused it is a large amount of freely
Base can also cause to damage to skin, accelerate the formation of color spot, melanin.DPPH is a kind of long-life free radical of stabilization, when having
In the presence of free radical scavenger, weaken DPPH light absorbs due to being matched with its single electron, evaluate material whereby and remove freely
The ability of base, so as to evaluate its oxidation resistance.The present invention determines absorbance, detection is real by DPPH free radical neutralization tests
Example 3, shin moisturizer made from comparative example 1-4 are applied to the clearance rates of DPPH free radicals, to evaluate the anti-of shin moisturizer produced by the present invention
Oxidation effectiveness, as a result it see the table below shown in 4.
Clearance rate of each group shin moisturizer of table 4 to DPPH free radicals
From upper table 4, shin moisturizer provided by the invention can effectively remove DPPH free radicals, show activity shield of the invention
Skin composition each component compounding is reasonable, mutually coordinated, has preferable antioxidant effect, suppresses the formation of color spot, melanin.
Test example five, after-sun performance test
Screening face has the volunteer patients 100 damaged after solarization in various degree, and injury symptoms are respectively red and swollen, de- after solarization
Skin and drying, are randomly divided into 5 groups, every group of 20 people, respectively embodiment 3, comparative example 1-4 groups, each group respectively using embodiment 3,
Shin moisturizer made from comparative example 1-4, respectively use 1 time, be used continuously 4 weeks sooner or later, skin injury after evaluation each group volunteer patients shine
The situation of reparation, as a result it see the table below shown in 5 and 6.
The each group shin moisturizer of table 5 improves skin efficacy assessments
| Group | Moisture content of skin (%) | The change of skin mean roughness (△ R3, μm) | Skin elasticity (Ur/Uf) |
| Embodiment 3 | 49.38±5.28 | 40.57±4.62 | 0.94±0.12 |
| Comparative example 1 | 45.69±5.02 | 37.24±4.05 | 0.86±0.10 |
| Comparative example 2 | 42.74±4.85* | 34.80±3.75* | 0.74±0.09* |
| Comparative example 3 | 36.68±3.64** | 30.96±2.62** | 0.60±0.08** |
| Comparative example 4 | 42.02±5.79* | 33.75±4.26* | 0.70±0.12* |
Note：Compared with embodiment 3, P*＜ 0.05, P**＜ 0.05.
The after-sun effect of each group shin moisturizer of table 6
From upper table 5, the roughened state of skin can be effectively improved using shin moisturizer made from the embodiment of the present invention 3, is carried
The water content of high skin, make skin high resilience.From upper table 6, after shin moisturizer can promote solarization made from the embodiment of the present invention 3
The reparation of wound, to caused malaise symptoms after solarization as dry, decortication and redness are respectively provided with certain therapeutic effect.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of active skincare composition, it is characterised in that described skin care compositions includes the component of following portions by weight：
1~10 part of natural pigment alcohol plastid；
0.05~4 part of enoxolone；
0.05~2 part of palmatine；
0.1~1 part of cysteinyl glycine；
0.1~1 part of L- Vitamin C acyls palmitate.
2. active skincare composition according to claim 1, it is characterised in that described skin care compositions also includes shellac
0.01~1 part of acid.
3. active skincare composition according to claim 1, it is characterised in that described skin care compositions also includes mountain region
1~10 part of rose callus cell suspending nutrient solution freeze-dried powder.
4. active skincare composition according to claim 3, it is characterised in that described skin care compositions includes following heavy
Measure the component of number：
5~8 parts of natural pigment alcohol plastid；
1~2 part of enoxolone；
0.1~1 part of palmatine；
0.5~1 part of cysteinyl glycine；
0.5~1 part of L- Vitamin C acyls palmitate；
0.1~0.5 part of shellolic acid；
6~10 parts of mountain region rose callus cell suspending nutrient solution freeze-dried powder.
5. according to any described active skincare compositions of claim 1-4, it is characterised in that described natural pigment alcohol plastid
Component including following portions by weight：0.1~1 part of natural pigment, 4~12 parts of soybean lecithin, 20~30 parts of ethanol, poly- second two
20~30 parts of 1~2 part of alcohol stearate, 3~5 parts of hydroxyethyl piperazineethanesulfonic acid and deionized water.
6. active skincare composition according to claim 5, it is characterised in that described natural pigment by chlorophyll and kind
Lycopene is with 1:0.1~1 mass ratio composition.
7. active skincare composition according to claim 6, it is characterised in that described natural pigment by chlorophyll and kind
Lycopene is with 1:0.6 mass ratio composition.
8. active skincare composition according to claim 6, it is characterised in that the preparation of described natural pigment alcohol plastid
Comprise the following steps：
Soybean lecithin is weighed, is dissolved with ethanol, then adds polyethylene glycol stearate, natural pigment, is well mixed；
400r.min-1Under conditions of, with peristaltic pump with 100 μ L.min-1Speed will the hydroxyethyl piperazineethanesulfonic acid water that dissolve in advance
In solution injection ethanol solution, injection finishes, 10000r.min-1Stirring 2min makes its homogenization, then equal by 200nm micropore
Plasma membrane processing, obtains alcohol plastid liquid, cools and solidifies, produces natural pigment alcohol plastid.
9. active skincare composition according to claim 4, it is characterised in that described mountain region rose callus cell
The preparation of suspending nutrient solution freeze-dried powder comprises the following steps：
(1) sterile mountain region Rose leaf is taken to be inoculated in MS+0.8~1.2mg/L 6-BA+1.2~2.0mg/L 2,4-D+4g/L
Callus induction is carried out in the solid medium of agar+25g/L sucrose, the squamous subculture time is 105~120 days, the company of selection
The callus for the loose ivory buff that continuous subculture is 3 times；
(2) the loose ivory buff callus for taking step (1) to obtain, mung bean size is divided into sterilized tweezers,
1/2MS+1.5 containing 40ml~2.0mg/L 6-BA+0.5~1.0mg/L 2,4-D+30g/L sucrose are seeded to, pH is 5.8 liquid
In the 100ml conical flasks of body culture medium, on 25 DEG C of constant-temperature table, 100rpm, suspended under the conditions of 12h/d light application times
Culture, after cultivating 15d, filtrate is taken after being sieved through filter with 50 aim cells, filtrate is sieved through filter with 80 aim cells again, takes filtrate, go out
Bacterium, it is lyophilized to produce.
10. a kind of active skincare composition as described in claim 1-9 is any is preparing with sun-proof repair function, is delaying skin
Application in skin aging, whitening spot-removing skin care item or cosmetics.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710986602.2A CN107550847B (en) | 2017-10-20 | 2017-10-20 | Active skin care composition and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710986602.2A CN107550847B (en) | 2017-10-20 | 2017-10-20 | Active skin care composition and application thereof |
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| CN107550847A true CN107550847A (en) | 2018-01-09 |
| CN107550847B CN107550847B (en) | 2020-07-03 |
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| CN112716874A (en) * | 2021-02-08 | 2021-04-30 | 福建片仔癀化妆品有限公司 | Moisturizing lotion containing moisturizing traditional Chinese medicine formula and preparation method thereof |
| CN112932992A (en) * | 2021-03-19 | 2021-06-11 | 徐晓芬 | A skin care composition for improving skin aging and skin elasticity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112716874A (en) * | 2021-02-08 | 2021-04-30 | 福建片仔癀化妆品有限公司 | Moisturizing lotion containing moisturizing traditional Chinese medicine formula and preparation method thereof |
| CN112932992A (en) * | 2021-03-19 | 2021-06-11 | 徐晓芬 | A skin care composition for improving skin aging and skin elasticity |
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| CN107550847B (en) | 2020-07-03 |
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