CN103619211A - Skin care kit comprising cosmetic compound and application method for the cosmetic compound - Google Patents
Skin care kit comprising cosmetic compound and application method for the cosmetic compound Download PDFInfo
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- CN103619211A CN103619211A CN201280031934.0A CN201280031934A CN103619211A CN 103619211 A CN103619211 A CN 103619211A CN 201280031934 A CN201280031934 A CN 201280031934A CN 103619211 A CN103619211 A CN 103619211A
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
- A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D40/00—Casings or accessories specially adapted for storing or handling solid or pasty toiletry or cosmetic substances, e.g. shaving soaps or lipsticks
- A45D40/26—Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
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Abstract
The present invention provides: a skin care kit which comprises a cosmetic compound containing arginine-and-lysine-containing polypeptides as an active ingredient and a skin applicator for applying the compound to skin; and an application method for the cosmetic compound. According to the invention, the effects of skin cooling, skin elasticity improvement and reducing wrinkles are provided.
Description
Technical field
The present invention relates to a kind of beautifying skin instrument and smearing method that contains cosmetic composition, more particularly, relate to a kind of beautifying skin instrument and smearing method by applying tension with the cosmetic composition of excellent skin refreshing effect that contain.
Background technology
Conventionally, the object of cosmetics is to make clean body, modifies that self is more beautiful and charming, and in addition, its object is to protect skin or hair etc. away from ultraviolet ray or dry, thereby prevents aging.Be accompanied by the progress of recent business community and the increase of social activities, the sense of independence of actively showing self has had raising, meanwhile, utilize cosmetics maintenance self skin, maintain healthy demand and also significantly increase, and then studied and developed the basic cosmetics of various forms or formulation.
The elastic force of skin is that the elastomer being formed with the elastin laminin (elastin) by being present in skin corium shows, this elastomer just has low-down coefficient of elasticity as rubber, therefore, even if applying small power also can easily be out of shape, in addition, when removing this power, easily restore to the original state again.In addition, elastomer has the form of inserting microfibre (microfibrils) in this amorphous matrix of elastin laminin, and elastin laminin is the protein being comprised of the desmosine that is derived from lysine (desmosine) and very unique amino acid such as isodensmosine (isodesmosine) of only finding in elastomer.Described desmosine and isodensmosine form crosslinked (cross-links) in long peptide chain, and this structure makes elastin laminin have the character as rubber.
In addition, the elastomer being comprised of elastin laminin coexists with the collagenous fibres that are called collagen (collagen), under the state fully existing, can maintain the elastic force of skin at elastin laminin and collagen.
On the other hand, it is to cause the generation of elastin laminin decline and destroy because aging or ultraviolet etc. makes Skin Cell (fibroblast) decline that skin elastic force reduces, thereby bring out.Ultraviolet ray etc. causes finding elastin laminin digestive enzyme in skin, and the normal elastin laminin in this enzyme degraded skin, reduces skin elastic force.In addition, the reduction of the elastic force of skin is also that Protein Damage and generation rate reduction occur owing to forming more than 70% collagen of dermis of skin.Collagen is also because this digestive enzyme of clostridiopetidase A (collagenase) that ultraviolet ray etc. is brought out is degraded.The existing existing patent relevant to increasing skin elastic force, in order to demonstrate the effect that improves skin elastic force, only suppresses the activity of clostridiopetidase A simply, or the activity that suppresses elastoser, their shortcoming is, only for tailor-made, is used in skin corium, cannot make effect maximize.
On the other hand, recently weather continues to polarise, and summer is elongated, thereby can make in sultry summer the temperature of skin decline and the care degree that becomes calm product increases.In fact, owing to making up, can stop up the pore of skin, produce the sensation of heating, and, if sweat, can make cosmetics disappear, therefore, in the women that must make up every day, the necessity with the cosmetics of salubrious sense increases.Thus, as summer product through the object of product sold, be, make due to hot summer weather become boiling hot skin cool off cooling, thereby make people calm, pore refining and make people feel to improve.Specifically, common cosmetic product is to use the compositions such as menthol, menthol derivative, xylitol as the product of salubrious agent mostly, cannot fully make people experience at once salubrious effect.
Summary of the invention
The object of the present invention is to provide a kind of beautifying skin instrument and smearing method, it utilizes skin application device that the cosmetic composition containing as the polypeptide that comprises arginine and lysine of active component is applied on skin, thereby produces the excellent skin refreshing effect of passing through to utilize tension that common smearing method cannot represent.
To achieve these goals, the invention provides a kind of beautifying skin kit containing the cosmetic composition of the polypeptide that comprises arginine and lysine as active component and for above-mentioned cosmetic composition being applied in to the skin application device of skin.
In one embodiment of the invention, above-mentioned skin application device can be at least one device roller, pressure indicator and the massager from applying tension.
In one embodiment of the invention, above-mentioned skin application device can be ballpoint (roll-on).
In one embodiment of the invention, the ball of above-mentioned ballpoint can be at least 3.
In one embodiment of the invention, above-mentioned cosmetic composition can also contain at least one extract being selected from oat extract and yeast extract.
In one embodiment of the invention, the polypeptide that comprises arginine and lysine of 0.01～2 % by weight that above-mentioned cosmetic composition can contain with good grounds described composition total weight is, the yeast extract of the oat extract of 2～6 % by weight and 0.01～0.5 % by weight.
In one embodiment of the invention, above-mentioned cosmetic composition can also contain at least one material being selected from adenosine, retinol and niacinamide.
In one embodiment of the invention, above-mentioned beautifying skin instrument can have skin refreshing purposes, skin elastic force improves purposes and wrinkle of skin improves at least one purposes in purposes.
In addition, the invention provides a kind of smearing method of cosmetic composition, it comprises the steps,, when the cosmetic composition of the polypeptide that contains arginine and lysine as active component is applied in skin or after smearing, utilize skin application device to apply tension to skin.
In one embodiment of the invention, above-mentioned smearing method can have skin refreshing purposes, skin elastic force improves purposes and wrinkle of skin improves at least one purposes in purposes.
The effect of invention
According to the present invention, a kind of beautifying skin instrument and smearing method are provided, its skin application device that can apply tension by utilizing applies the cosmetic composition with skin elastic force raising effect to skin, and not utilize common smearing method, thereby can make cosmetic composition and smearing method, the two produces synergistic effect, thereby shows the effect of more excellent skin refreshing, the raising of skin elastic force, wrinkle of skin minimizing.
accompanying drawing explanation
The photo of the variation of actin when Fig. 1 means the related tension of one embodiment of the present of invention.
Fig. 2 is in the situation that used the curve map of relative expression quantity of the collagen of the related cosmetic composition of one embodiment of the present of invention and tension.
Fig. 3 is the drawing in side sectional elevation of the related skin application device of one embodiment of the present of invention.
Fig. 4 is the oblique view of upper spheres setting unit (a) and the lower spheres setting unit (b) of the related skin application device of one embodiment of the present of invention.
Fig. 5 means the curve map of the measurement result of the skin refreshing experiment in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
Fig. 6 means the curve map of the skin temperature slip in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
Fig. 7 is in the situation that use related cosmetic composition and the skin application device of one embodiment of the present of invention, takes skin temperature near the eyes and the photo that obtains.
Fig. 8 means the curve map of the measurement result of the experiment of wrinkle near the eyes in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
Fig. 9 means the curve map of the slip of wrinkle near the eyes in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
Figure 10 is in the situation that use related cosmetic composition and the skin application device of one embodiment of the present of invention, takes wrinkle near the eyes and the photo that obtains.
Figure 11 means the curve map of the elastic force increment rate near the eyes in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
Figure 12 means the curve map of the measurement result of the elastic force experiment near the eyes in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
Figure 13 means the curve map (a) of DBF and the schematic diagram (b) of CBF in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
Figure 14 means the curve map (a) of uptake and the curve map (b) of infiltration rate of the active component in the situation of using the related cosmetic composition of one embodiment of the present of invention and skin application device.
The explanation of Reference numeral
10 bottom container
20 upper containers
30 upper spheres setting units
40 lower spheres setting units
50 lid outer covers
60 lid inner covers
70 covers are decorated
80 liners
90 balls.
The specific embodiment
Below, in order to make those skilled in the art more easily implement the present invention, to a preferred embodiment of the present invention will be described in detail.
The invention provides a kind of beautifying skin instrument, this beautifying skin kit is containing the cosmetic composition of the polypeptide that contains arginine and lysine as active component and for above-mentioned cosmetic composition being applied in to the skin application device of skin.Above-mentioned cosmetic composition itself has salubrious skin, raising skin elastic force and improves the effect of wrinkle of skin.
In the situation that above-mentioned cosmetic composition is spread upon on skin, on one side utilize skin application device skin to be applied to tension on one side, smear.Above-mentioned skin application device is not particularly limited, and can be at least one device being selected from roller, pressure indicator and the massager of granting tension.
Tension refers to exerts pressure and makes the physical stimulation of skin expansion and contraction skin.Tension can be strengthened the cytoskeletal protein of Skin Cell.As shown in Figure 1, when applying tension, the actin in fibroblastic cytoskeletal protein can be reinforced.
In addition, the gene that tension can be impelled the anti-aging of Skin Cell and improve barrier function is expressed.Result of study related to this is as shown in the table.
In addition, tension can also be improved the CBF of skin, promotes the material absorbing of skin.And, also contribute to the effect of improving of the salubrious effect of instantaneity of skin and wrinkle of skin, elastic force.To this, in following test case, confirmed above-mentioned effect.
The tension of utilizing skin application device to apply skin, can produce massage effect and promote the effect that active component permeates, therefore, contribute to contain as comprising of active component above-mentioned arginine and lysine the skin elastic force of cosmetic composition of polypeptide improve effect and better brought into play.In addition, because skin application device directly contacts with skin, in conduction skin heat, apply tension, therefore, can make skin refreshing effect better be brought into play.That is,, by use above-mentioned cosmetic composition and skin application device simultaneously, can produce salubrious skin, raising skin elastic force, improve the synergy of wrinkle of skin texts.
Preferred above-mentioned skin application device is ballpoint (roll-on).The ball of above-mentioned ballpoint can be 1, more than 2 or 3.As long as described ballpoint makes spherical ball and skin contact, be not particularly limited.
As an example, the ball in described skin application device shown in Figure 3 is the ballpoint of 3.Fig. 3 a is the drawing in side sectional elevation of ballpoint, is the drawing in side sectional elevation of 2 running through in 3 balls.Fig. 3 b is the drawing in side sectional elevation of 1 running through in 3 balls.Fig. 4 is the Local map of above-mentioned ballpoint, is the oblique view of upper spheres setting unit (a) and lower spheres setting unit (b).
Specifically, as shown in Figure 3, cosmetic composition is stored in bottom container 10 inside, and lower spheres setting unit 30 supports the bottom of ball 90, and upper spheres setting unit is ball 90 fixedly.Ball 90 is spherical metal ball, and be formed on the state rotating between bottom and upper spheres setting unit, in addition, cosmetic composition is applied on the surface of ball of internal tank side, ball rotates and smeared cosmetic composition is passed to outside, thereby smears to skin.After ballpoint is used, can take care of by closed lid, lid is to cover outer cover 50 and the overlapping and formation of inner cover 60.Above-mentioned Fig. 3 is only illustration of the present invention, is not limited thereto.
Above-mentioned cosmetic composition can also contain at least one the extract in oat extract and yeast extract.Now, above-mentioned cosmetic composition is preferably according to the yeast extract of the oat extract of the polypeptide that comprises arginine and lysine of 0.01～2 % by weight of described composition total weight, 2～6 % by weight and 0.01～0.5 % by weight, and more preferably the polypeptide that comprises arginine and lysine of 0.01～1.5 % by weight is, the yeast extract of the oat extract of 3～5 % by weight and 0.06～0.2 % by weight.When comprise above-mentioned scope intensive amount above-mentioned substance time, can, in the effect of each active component of performance for skin, can also maintain the stability of skin.
In addition, above-mentioned cosmetic composition can also contain at least one material being selected from adenosine, retinol and niacinamide.Preferably, according to described composition total weight, adenosine has 0.01～0.07 % by weight, and retinol has 50～150 IU.
The polypeptide that comprises arginine and lysine used in the present invention has following effect, that is, promote constituent synthetic of the extracellular matrixs such as type i collagen, III Collagen Type VI, V Collagen Type VI, proteoglycans (Decorin, proteoglycane), hinder the release of MMP-1, prevent aging.Mainstream product in commercial arginine and lysine polypeptide, can enumerate the PEPTISKIN of Solabia company
?deng.PEPTISKIN
?the 40% dry extraction solution being formed by L-arginine and 1B oligopeptides, registration is 2～7, this product obtains by non-solvent ferment synthetic method.
Oat extract used in the present invention extracts and obtains from oat (Oat).Oat is the cereal also referred to as Avena sativa, and oat, owing to having the protein of high-quality, is rich in the inorganic matters such as phosphorus, magnesium, calcium, therefore, is not only applicable to diet food, and constipation is also produced effect, and is mainly used in eating.The oat extract that cosmetic composition of the present invention is used extracts by common grain extract manufacture method.As an example, can oat is dry after or directly pulverize and the crushed material that obtains can by be for example selected from distilled water, organic solvent with and composition thereof in solvent extract.Now, the organic solvent using can be 1,3-BDO, C1 ~ C4 lower alcohol, and ethyl acetate or acetone, in addition, also can, according to the polarity of above-mentioned organic solvent, be used at least two kinds of described materials in order.In commercial oat extract as mainstream product, can enumerate the OSILIFT of Silab company
?deng.OSILIFT
?being oat benevolence (Oat kernel) extract, is to have excellent instant effect of skin-lifting and the material of wrinkle remission effect.
Yeast extract used in the present invention ferments yeast to carry out obtaining after purifying, extraction by microorganism.Conventionally, yeast extract has the synthetic function that promotes type Ⅳ collagen, VII Collagen Type VI and integrin (Integrin), has TGF-β 1 activity.Therefore, there is anti-wrinkle effect and strengthening corium-epidermis contact (Dermis-Epidermis Junction) effect.Yeast extract, so long as common extracting method is not particularly limited, can be prepared by following method.; after in yeast (Saccharomyces Cerevisiae) is dissolved in to water, by filtration, the part of dissolving is separated with undissolved part, then; the part of dissolving is taken out separately and concentrated, then filter and obtain yeast extract (yeast extract).In commercial yeast extract as mainstream product, can enumerate the TONISKIN of Silab company
?(also referred to as Yeast extract) etc.
Above-mentioned beautifying skin instrument can contain above-mentioned cosmetic composition in skin application device inside, also can not contain cosmetic composition in skin application device inside, but accommodates separately cosmetic composition.
The invention provides a kind of smearing method of cosmetic composition, it comprises the steps, that is,, when the cosmetic composition of the polypeptide that contains arginine and lysine as active component is applied in skin or after smearing, utilize skin application device to apply tension to skin.
In above-mentioned smearing method, above-mentioned skin application device can be ballpoint (roll-on).The ball of above-mentioned ballpoint can be 1, more than 2 or 3.
Described ballpoint so long as the form of spherical ball and skin contact be not particularly limited.
The use of the involved in the present invention skin application device that utilizes cosmetic composition, by contain there is the yeast extract of corium-epidermis contact strengthening effect and have the instant wrinkle remission effect that natural polysaccharide (polyose) brings oat extract etc. cosmetic composition and by rolling, there is massage effect and promote the ballpoint massager of active component osmotic effect, thereby can realize salubrious skin and improve the synergy of elastic force.
Especially, when using ballpoint type skin application device, due to without cosmetic composition can not absorbed by hand with hand, thereby can smear more composition at desired area, but also can use at any time.Further, can not be subject to the restriction of the use senses such as sticky hand or residual sense, thus can the agent of excessive use consolidation, polymer etc.Especially, the advantage when using ballpoint type skin application device is, produces massage effect along with applying tension, thereby improves CBF, promotes the absorption of active component, so show skin refreshing effect, wrinkle improves effect and elastic force improves effect.
Enforcement by below and the present invention is described in further detail.Wherein, embodiment is only for illustration example of the present invention, can not limit thus scope of the present invention.
The expression determination experiment of ［ test case 1 ］ collagen
Measured the relative expression quantity with respect to the collagen of SF.First, relatively to SF, apply tension before with afterwards.With 0.5Hz, 17%, stretch and implement tension one hour.In addition, as the polypeptide that comprises arginine and lysine, pass through to use PEPTISKIN
?(manufacture of Solabia company) processed SF, before then relatively applying the tension of above-mentioned the same terms and after applying tension.Its result as shown in Figure 2.
As shown in Figure 2, can confirm, only apply tension and also can make the collagen expression amount of SF increase.In addition, the SF after processing with PEPTISKIN is applied in the situation of tension, can be observed the peak of collagen expression amount.That is, apply at the same time in tension the situation with PEPTISKIN processing, can demonstrate synergy, thereby show the most excellent effect.
［ embodiment 1 ］
As oat extract, used commodity to be called OSILIFT
?the oat extract of (manufacture of Silab company).As the polypeptide that comprises arginine and lysine, used the polypeptide of commodity PEPTISKIN (manufacture of Solabia company) by name.As yeast extract, used commodity to be called TONISKIN
?the yeast extract of (manufacture of Silab company).And be mixed with the OSILIFT of 4 % by weight
?, 0.01 % by weight PEPTISKIN
?, 0.5 % by weight TONISKIN
?, 0.04 % by weight adenosine and retinol 100IU.With the ratio shown in following table 1, add material and prepare Essence.
Above-mentioned prepared Essence is injected as the ballpoint applicator of skin application device inner.The ballpoint applicator using as shown in Figure 3.
[table 1]
The experiment of ［ test case 2 ］ skin refreshing
Use the prepared Essence of above-described embodiment 1,10 experimenters of experimenter of usining carry out clinical testing as object.10 experimenters' of experimenter age is 32 ± 3.2 years old.Each experimenter's right eye is tested as a control group as test group, left eye.
After experimenter washes one's face, in 22～28 ℃, the thermostatic constant wet chamber of relative humidity 108～42%, first adapt to 15 minutes.Utilize the ballpoint applicator as skin application device of the present invention massage experimenter's test group 30 seconds, then smear the Essence of above-described embodiment 1, on control group, with hand, smear the identical emulsion of same amount and make it and absorb.Then, the face before smearing Essence and after just having smeared is taken pictures.
Utilize skin temperature to measure camera (IR camera, CAM PM575, FLIR.USA), observe instant skin temperature and change.Its result is shown in Fig. 5～Fig. 7.
Known according to Fig. 5, Fig. 6, before using ballpoint applicator and after just having used, near the eyes skin near the eyes the temperature of skin decrease, in addition, skin temperature slip is far away higher than control group.2 experimenters' that take with the camera shown in Figure 7 distribution of skin temperature near the eyes photo.According to Fig. 7, also can confirm following situation,, in test group, the difference that skin temperature reduces is more obvious, and this has proved that the present invention has excellent instant salubrious effect.
The experiment of ［ test case 3 ］ wrinkle of skin
Use prepared Essence in above-described embodiment 1, experimenter's test group and control group and above-mentioned test case 2 are carried out to wrinkle of skin experiment in the same manner.
Before measuring respectively the Essence smeared embodiment 1, afterwards, use after 2 weeks, 4 weeks afterwards and after 8 weeks.
When portion takes over there, use wrinkle determining instrument (primos, GFMESSTECHNIK. Germany), wrinkle is near the eyes taken, observe the variation of wrinkle near the eyes.Measurement result is shown in Fig. 8 and Fig. 9, and photo is shown in Figure 10.Table 2 represents the result of paired t-test, and, with respect to the significant difference before using, table 3 illustrates the result of independentt-test, i.e. significant difference between group.
[table 2]
With respect to the significant difference before using
[table 3]
Significant difference between group
Known according to Fig. 8 and Fig. 9, at use test set product, after 8 weeks, wrinkle has reduced 11.7% near the eyes.On the contrary, for control group product, till 8 weeks, for not showing wrinkle, reduce function.In addition, known according to Figure 10, compared with the 0th week, used after 8 weeks, can be observed visually the minimizing of wrinkle near the eyes.In addition, known according to table 2 and table 3, at product, used after 8 weeks, the wrinkle between test group and control group improves in function, can confirm with respect to the significant difference (significant difference * p < 0.05) before using and between group.Can think that this is due to the rolling of ballpoint applicator, to have promoted the absorption of active component.
The experiment of ［ test case 4 ］ skin elastic force
Use the prepared Essence of above-described embodiment 1, experimenter's test group and control group have been carried out to skin elastic force in the same manner with above-mentioned test case 2 and tested.
Before measuring respectively the Essence smeared embodiment 1, afterwards, use after 2 weeks, 4 weeks afterwards and after 8 weeks.
When portion takes over there, use skin elasticity tester device (Cutometer580
?, C+K, Germany), the variation of skin elastic force is near the eyes observed.Its result is shown in Figure 11 and Figure 12.
Known according to Figure 11 and Figure 12, used test set product after 2 weeks, 4 weeks and 8 weeks, there is following trend, elastic force increases respectively 0.4%, 6.6% near the eyes, 9.1%(p=0.062).On the contrary, in the situation for control group product, till 8 weeks, only showing elastic force near the eyes increases by 2.7% trend.Can think that this is because ballpoint applicator produces massage effect near the eyes.
The experiment of ［ test case 5 ］ blood flow determination
Use the prepared Essence of above-described embodiment 1, experimenter's test group and control group and above-mentioned test case 2 have been measured in the same manner to the CBF of skin.Its result ((a) is according to correlation curve figure, (b) blood flow photo of smearing the different CBFs that change of mode) shown in Figure 13.
Known according to Figure 13 a, with use ballpoint applicator of the present invention before compare, the CBF after use approximately increases by 40%, and reduces on the contrary with the CBF of the control group of hand.In addition, known according to Figure 13 b, the numerical value of Perfusion color scale uprises and approaches redness and just represents that VPV is faster, numerical value declines and the cyan that more approaches cool colour system just represents that VPV is slower, therefore, can confirm with smear before compare, VPV has accelerated.Thus, confirmed that the massage effect that ballpoint applicator of the present invention produces can make blood flow increase.
［ test case 6 ］ promotes the experiment of skin assimilation effect
Use the prepared Essence of above-described embodiment 1, to experimenter's test group and control group and above-mentioned test case 2 in the same manner, measured the skin degree of absorption of active component.Its result ((a) is according to smearing correlation curve figure, (b) infiltration rate correlation curve figure of the active component uptake that mode is different) shown in Figure 14.
Known according to Figure 14 a, when using ballpoint applicator of the present invention, to compare with the situation of smearing with hand, the uptake of active component approximately increases by 40%, and known according to Figure 14 b, absorptivity approximately increases by 2 times.Therefore, can confirm following situation, that is, in the situation that using ballpoint applicator of the present invention, the physical stimulation by ballpoint makes active component increase to the transmission capacity of skin, the massage effect that ballpoint produces and initial absorption speed is increased.
Claims (16)
1. a beautifying skin instrument, is characterized in that,
This beautifying skin kit is containing the cosmetic composition of the polypeptide that contains arginine and lysine as active component and for above-mentioned cosmetic composition being applied in to the skin application device of skin.
2. beautifying skin instrument according to claim 1, is characterized in that,
Above-mentioned skin application device is at least one device that is selected from roller, pressure indicator and massager for applying tension.
3. beautifying skin instrument according to claim 1, is characterized in that,
Above-mentioned skin application device is ballpoint.
4. beautifying skin instrument according to claim 3, is characterized in that,
The ball of above-mentioned ballpoint is at least 3.
5. beautifying skin instrument according to claim 1, is characterized in that,
Above-mentioned cosmetic composition further contains at least one extract being selected from oat extract and yeast extract.
6. beautifying skin instrument according to claim 5, is characterized in that,
Above-mentioned cosmetic composition contains the polypeptide that comprises arginine and lysine of 0.01～2 % by weight of with good grounds described composition total weight, the yeast extract of the oat extract of 2～6 % by weight and 0.01～0.5 % by weight.
7. beautifying skin instrument according to claim 1 or 5, is characterized in that,
Above-mentioned cosmetic composition further contains at least one material being selected from adenosine, retinol and niacinamide.
8. beautifying skin instrument according to claim 1, is characterized in that,
Above-mentioned beautifying skin instrument has skin refreshing purposes, skin elastic force improves purposes and wrinkle of skin improves at least one purposes in purposes.
9. a smearing method for cosmetic composition, is characterized in that,
This smearing method comprises the steps:
After containing when the cosmetic composition of the polypeptide that comprises arginine and lysine of active component is applied in skin or smearing, utilize skin application device to apply tension to skin.
10. the smearing method of cosmetic composition according to claim 9, is characterized in that,
Above-mentioned smearing method has skin refreshing purposes, skin elastic force improves purposes and wrinkle of skin improves at least one purposes in purposes.
The smearing method of 11. cosmetic compositions according to claim 9, is characterized in that,
Above-mentioned skin application device is at least one device that is selected from roller, pressure indicator and massager for applying tension.
The smearing method of 12. cosmetic compositions according to claim 9, is characterized in that,
Above-mentioned skin application device is ballpoint.
The smearing method of 13. cosmetic compositions according to claim 12, is characterized in that,
The ball of above-mentioned ballpoint is at least 3.
The smearing method of 14. cosmetic compositions according to claim 9, is characterized in that,
Above-mentioned cosmetic composition further contains at least one extract being selected from oat extract and yeast extract.
15. according to the smearing method of the cosmetic composition described in claim 9 or 14, it is characterized in that,
Above-mentioned cosmetic composition further contains at least one material being selected from adenosine, retinol and niacinamide.
The smearing method of 16. cosmetic compositions according to claim 14, is characterized in that,
Above-mentioned cosmetic composition contains the polypeptide that comprises arginine and lysine of 0.01～2 % by weight of with good grounds described composition total weight, the yeast extract of the oat extract of 2～6 % by weight and 0.01～0.5 % by weight.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110062111A KR101805690B1 (en) | 2011-06-27 | 2011-06-27 | Kit for skin beauty including cosmetic composition and method for applying the cosmetic composition |
| KR10-2011-0062111 | 2011-06-27 | ||
| PCT/KR2012/004953 WO2013002518A2 (en) | 2011-06-27 | 2012-06-22 | Skin care kit comprising cosmetic compound and application method for the cosmetic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103619211A true CN103619211A (en) | 2014-03-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280031934.0A Pending CN103619211A (en) | 2011-06-27 | 2012-06-22 | Skin care kit comprising cosmetic compound and application method for the cosmetic compound |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP6153520B2 (en) |
| KR (1) | KR101805690B1 (en) |
| CN (1) | CN103619211A (en) |
| WO (1) | WO2013002518A2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107548286A (en) * | 2015-03-17 | 2018-01-05 | 株式会社爱茉莉太平洋 | Cosmetic composition dauber including non-transmission layer |
| CN107734995A (en) * | 2015-06-11 | 2018-02-23 | 宝洁公司 | For changing the apparatus and method of keratinous surfaces |
| CN107854355A (en) * | 2017-11-18 | 2018-03-30 | 上海煓梅生物科技有限公司 | A kind of anti-apolexis composition and its preparation method and application |
| CN109512710A (en) * | 2017-09-18 | 2019-03-26 | 玫琳凯有限公司 | Cosmetic composition and method |
| US12036296B2 (en) | 2014-12-04 | 2024-07-16 | Mary Kay Inc. | Cosmetic compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5828355B1 (en) * | 2014-09-22 | 2015-12-02 | 和伎獅子株式会社 | Powdered skin external preparation for hair growth / hair growth and skin condition improvement |
| WO2017091010A1 (en) * | 2015-11-25 | 2017-06-01 | 주식회사 파이안에스테틱스 | Water-soluble microneedle spicules and nonaqueous cosmetic composition containing same |
| JP6621031B2 (en) * | 2017-01-12 | 2019-12-18 | パナソニックＩｐマネジメント株式会社 | Beauty equipment |
| CN111356467A (en) * | 2017-11-17 | 2020-06-30 | 株式会社资生堂 | VE-cadherin expression promoter and/or integrin α 5 expression promoter |
| JP6967482B2 (en) * | 2018-03-30 | 2021-11-17 | 岡山大鵬薬品株式会社 | Formulation for skin application |
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| US12036296B2 (en) | 2014-12-04 | 2024-07-16 | Mary Kay Inc. | Cosmetic compositions |
| CN107548286A (en) * | 2015-03-17 | 2018-01-05 | 株式会社爱茉莉太平洋 | Cosmetic composition dauber including non-transmission layer |
| CN107734995A (en) * | 2015-06-11 | 2018-02-23 | 宝洁公司 | For changing the apparatus and method of keratinous surfaces |
| CN107734995B (en) * | 2015-06-11 | 2021-11-30 | 宝洁公司 | Apparatus and method for modifying keratinous surfaces |
| CN109512710A (en) * | 2017-09-18 | 2019-03-26 | 玫琳凯有限公司 | Cosmetic composition and method |
| US12097279B2 (en) | 2017-09-18 | 2024-09-24 | Mary Kay Inc. | Cosmetic compositions and methods |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2014520797A (en) | 2014-08-25 |
| JP6153520B2 (en) | 2017-06-28 |
| KR101805690B1 (en) | 2018-01-10 |
| WO2013002518A2 (en) | 2013-01-03 |
| WO2013002518A3 (en) | 2013-04-04 |
| KR20130010096A (en) | 2013-01-25 |
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