CN103932968A - Eye gel and preparation method thereof - Google Patents
Eye gel and preparation method thereof Download PDFInfo
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- CN103932968A CN103932968A CN201410145516.5A CN201410145516A CN103932968A CN 103932968 A CN103932968 A CN 103932968A CN 201410145516 A CN201410145516 A CN 201410145516A CN 103932968 A CN103932968 A CN 103932968A
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Abstract
The invention discloses eye gel and a preparation method thereof. According to the eye gel, anti-aging and anti-oxidizing agent-carnosine, eyeseryl and argireline acetate are compounded in a matrix formulation; meanwhile, active ingredients such as sodium hyaluronate, oat beta-glucan, polysaccharide skin firming agent and the like, and a plurality of Chinese herbal medicine essences such as poria cocos extracts and frankincense extracts are added. The eye gel is capable of tightening the eye skin, fading the eye wrinkles, improving the black eyes, comprehensively nourishing the eye skin and enabling the eyes to be bright. The eye gel is uniform in color, fresh in texture and easy to absorb.
Description
One, technical field
The present invention relates to a kind of skin care item and preparation method thereof, specifically a kind of glue and preparation method thereof.
Two, background technology
Defying age is the eternal topics of the mankind, and with age, a series of variations can occur the defencive function of skin, cause the obstacle of skin metabolism, make skin aging.The present invention mainly by moisturizing, repair skin barrier function, antioxidation and compact and the approach such as lift and come defying age.
Skin physiology thinks, the moisturizing mechanism of skin is that the sebum film based on be coated on skin surface by smegma suppresses moisture through skin evaporation and is present in the result of two kinds of effects of the water solublity moisture absorption composition (being called nature moisturizing factor NMF) in horn cell.And in Skin Cell and connective tissue water content seldom, therefore, the moisture increasing in Skin Cell and connective tissue is the effective measures of prevention skin aging and dermatosis.Conventionally anti-aging product formula can be allocated wetting agent into, to can and more absorb moisture deep skin from air, carry out skin care, wetting agent can provide a closure barrier to reduce the loss of percutaneous moisture on skin, some also, by the moisture absorption in environment is arrived to skin, plays a role as wetting agent.
In anti-aging cosmetics, adding hyaluronate sodium, avenabeta glucosan and tetrem acyl phytosphingosine is exactly moisturizing and the Typical Representative of repairing skin barrier function.Hyaluronate sodium is the best moisturizing composition that current occurring in nature is found, acts on skin surface, can form the thin film that one deck is ventilative, makes skin smooth moistening, and can intercept alien bacteria, dust, ultraviolet intrusion, and protection skin is avoided infringement.From Herba bromi japonici, the separated avenabeta glucosan obtaining, has efficient performance of keeping humidity, can lock moisture of skin, gives skin and moisten smooth sense of touch as silk; Can immediately tighten up and softening tiny wrinkle, improve skin texture degree; Unique straight-chain molecular structure, makes its Transdermal absorption performance good, can be used as the release vehicle of active component.Tetrem acyl phytosphingosine can make skin pore in the level and smooth configuration state of elasticity, makes skin possess deep moisturizing ability, and can effectively avoid black-eyed appearance.
Along with the increase at age, body protective mechanism declines, body physiological damage, and the quantity of free radical is gathered too much, causes lipid peroxidation, therefore, how effectively to remove oxygen-derived free radicals, just becomes to antidotal powerful measure.At present, resist and eliminate free radical, preventing the damaging action of free radical, often by antioxidant, being achieved.
The effect of antioxidant is just to provide a hydrogen atom and forms rock-steady structure in conjunction with free radical, has replaced the oils and fats molecule as hydrogen donor.In recent years, polypeptide class antioxidant with its safety, stable, easily absorb, the advantage such as effective playing the part of more and more important role.Because it has biological nature, add in cosmetics and can fundamentally improve, repair the variety of issue that skin occurs, aspect supplementary skin nutrition, crease-resistant, anti-ageing waiting for a long time, effect is remarkable especially.Wherein, carnosine adds in cosmetics, can prevent the injury to skin of free radical and saccharification react, effectively slows down the aging of skin, and can play whitening function; It can stop the crosslinked of macromole (as collagen protein), repairs aging human body cell, is a kind of natural defying age, antioxidant; Its lipid oxidation that free radical and metal ion are caused has obvious inhibitory action, in cosmetics direction, has good application prospect.An eye silk ammonia peptide can promote collagen protein synthesis, thereby increases tight skin solidity, for care product and various anti-aging product near the eyes, can eliminate edema, and eye haustra-dsipelling, improves skin elasticity and smoothness.Acetyl six peptides are effective biologically active polypeptide sequences of extracting from natural plants, and the degree of depth of energy aufhellung wrinkle, to locating the inhibitory action successful of histrionic muscles near eyes and forehead etc.In the market peptide active component is applied in skin care item comparatively generally, but yet there are no, carnosine is joined in eye skin care products.
The skin of around eyes is very tender and lovely; sebum secretion is few; moisture is difficult for keeping; add that skin is than other position thin (thinnest part only has 0.5 millimeter), contained collagen protein, elastin are less, so with advancing age; in addition the multiple injury of ultraviolet, bad life habits, pollution, color make-up; eye skin there will be the phenomenons such as various expression stricture of vaginas, age stricture of vagina, lax, edema, black eye conventionally, makes women look and presents a weathered appearance, and there is no spirit.Eye skin care products has moisturizing, moistens eye skin, delays the multiple effects such as wrinkle appearance, contributes to slow down aging.Eye colloid ground is clearly relatively applicable to neutrality or oily skin, uses without any burden, is therefore more and more subject to consumer's favor.
Three, summary of the invention
The present invention aims to provide a kind of glue and preparation method thereof, the defying age such as carnosine, eye silk ammonia peptide and acetyl six peptides, antioxidant is composite in eye gel matrix formula, add hyaluronate sodium, avenabeta glucosan, poly-polysaccharide Firm agent isoreactivity composition simultaneously, and the multiple Chinese herbal medicine elite such as Poria extract, Olibanum extract, make this glue there is moisturizing, lift compact, the multi-efficiency such as crease-resistant antioxidation, Vitamin K, allow eye skin be takeed good care of comprehensively.
The raw material of eye glue of the present invention consists of with E mutually A phase, B phase, C phase, D phase, and each raw material and proportioning are constructed as follows:
Each raw material gross mass is 100g.The all raw materials of the present invention are commercial.
Raw material is described as follows:
Bulbus Lilii extract, Ganoderma extract, Herba Leonuri extract and Radix Ophiopogonis extract, be pressed powder, purchased from Xuancheng City BAICAO plant Trade Co., Ltd.;
Olibanum extract (boswellic acid content is more than 40%), powder, purchased from U.S. Sa Binsha company;
Poria extract, the extracting solution of the Poria elite that quality percentage composition is 1%, solvent propylene glycol; Acetyl six peptide-3 solution, the quality percentage composition of acetyl six peptide-3 is 0.05%; Eye silk ammonia peptide solution, acetyl fourth peptide-5 that quality percentage composition is 0.1%.Above-mentioned three kinds of raw materials are the biochemical Industrial Co., Ltd. of Nanjing Si Baike and provide;
Carnosine, German De Zhixin company produces;
Tetrem acyl phytosphingosine, purchased from Shaanxi Sen Fu high-tech Industrial Co., Ltd.;
Poly-polysaccharide Firm agent (GLYCOLIFT), French plain Lai Biya company produces;
Acrylamide/acryloyl group dimethyl sodium taurocholate copolymer/2-Methylpentadecane/Polyoxyethylene Sorbitan Monooleate, French SEPPIC company produces;
Hyaluronate sodium, cosmetics-stage, molecular weight 1,390,000, purchased from Shandong Freda Biopharm Co., Ltd.;
Avenabeta glucosan (beta glucan content is greater than 10mg/mL), purchased from Beijing Sanyou Huizhi Biotechnology Co.ltd.
Polydimethylsiloxane and C16-18 alkyl polydimethylsiloxane cross linked polymer, commercial, trade name: Velvesil*DM Silicone (Cas#:756876-51-4), manufacturer: Momentive Performance Materials Japan LLC.
The preparation method of eye glue of the present invention is as follows:
A phase raw material is placed in to 75-80 ℃ of water-bath and stirs 25-30min, decorating film is dissolved, obtain compound A; Under stirring, in compound A, add C phase raw material, lower the temperature stir 25-30min in 75-80 ℃ of water-bath after, while being cooled to 40-45 ℃, add B phase raw material and stir, add successively D phase raw material and E phase raw material again, stir, temperature stops while being down to 30-35 ℃ stirring, discharging, obtains a glue.Can in preparation process, add distilled water so that finished product gross mass is 100g.
In eye glue of the present invention, add the wetting agent that glycerol, butanediol and betanin etc. can adsorption moisture, pantothenylol, nicotiamide, hyaluronate sodium etc. have the wetting agent of deep layer lock water function and avenabeta glucosan, tetrem acyl phytosphingosine etc. and have the deep moisturizing agent of repairing barrier function simultaneously.After above-mentioned wetting agent is composite, except thering is efficient performance of keeping humidity, can lock moisture of skin, give skin and moisten smooth sense of touch as silk; Can also improve skin texture, repair skin barrier function, make skin pore in the level and smooth configuration state of elasticity, make skin possess deep moisturizing ability, and can effectively avoid black-eyed appearance.
The interpolation of poly-polysaccharide Firm agent can allow eye glue of the present invention in circumference of eyes, form the 3D film with strength protection effect, as second layer skin, can reduce the injury to skin of ultraviolet and outside contamination; And it is lax to suppress eye, allows eye skin plastotype compact.
The present invention be take the peptide classes such as carnosine as main antioxidant, not only has high-efficient cleaning except the ability of free radical, and delay senility, makes cell more have vigor; The degree of depth that simultaneously can also aufhellung wrinkle, improves skin elasticity and smoothness; Promote collagen protein synthesis, eliminate edema, thereby increase tight skin solidity.Vitamin A palmitate, vitamin C glucoside and 3 kinds of vitamin derivatives of Vitamin E acetate are composite in eye glue, not only strengthen the antioxidation of peptide class, more can promote skin metabolism, strengthen the elasticity of skin, prevent pigmentation, improve skin gloss.
The present invention adds plants herb elite simultaneously.Poria extract energy consumer edema, highlights near the eyes; Olibanum extract have invigorate blood circulation, antiinflammatory, removal black eye and the effects such as skin of compacting; The combination of Bulbus Lilii extract, Herba Leonuri extract, Ganoderma extract and Radix Ophiopogonis extract, the water balance of energy regulation of skin, strengthening skin, the care that makes skin avoid outside stimulus to improve.
Eye of the present invention colloid ground is salubrious, is easy to, into ocular absorption, to have abundant moisturizing and oxidation resistance, can also invigorate blood circulation simultaneously, compacts, consumer edema, has Vitamin K, the profile near the eyes of compacting, removes the effect of eye pouch.Soft in formula, essence, parabens, gentle non-stimulated.
Four, accompanying drawing explanation
Fig. 1 is eye glue hydroscopicity of the present invention and time chart;
Fig. 2 be respectively 30 years old and 46 years old, oily skin two ages experimenter before on probation and try out after 42 days the comparison diagram of skin near the eyes.(a) be before 30 years old trier uses; (b) be after 30 years old trier uses; (c) be before 46 years old trier uses; (d) be after 46 years old trier uses.
Fig. 3 is age trier's eye on probation glue that is 55 years old comparison diagram of taking pictures before and after 30 minutes, (a) for before on probation; (b) for trying out design sketch after 15 minutes; (c) for trying out design sketch after 30 minutes.
Five, the specific embodiment
Embodiment 1:
1, the formula of eye glue:
Each raw material gross mass is 100g.
Raw material explanation:
Bulbus Lilii extract, Ganoderma extract, Herba Leonuri extract and Radix Ophiopogonis extract, be pressed powder, purchased from Xuancheng City BAICAO plant Trade Co., Ltd.;
Olibanum extract (boswellic acid content is more than 40%), powder, purchased from U.S. Sa Binsha company;
Poria extract, the extracting solution of the Poria elite that quality percentage composition is 1%, solvent propylene glycol; Acetyl six peptide-3 solution, the quality percentage composition of acetyl six peptide-3 is 0.05%; Eye silk ammonia peptide solution, acetyl fourth peptide-5 that quality percentage composition is 0.1%.Above-mentioned three kinds of raw materials are the biochemical Industrial Co., Ltd. of Nanjing Si Baike and provide;
Carnosine, German De Zhixin company produces;
Tetrem acyl phytosphingosine, purchased from Shaanxi Sen Fu high-tech Industrial Co., Ltd.;
Poly-polysaccharide Firm agent (GLYCOLIFT), French plain Lai Biya company produces;
Acrylamide/acryloyl group dimethyl sodium taurocholate copolymer/2-Methylpentadecane/Polyoxyethylene Sorbitan Monooleate, French SEPPIC company produces;
Hyaluronate sodium, cosmetics-stage, molecular weight 1,390,000, purchased from Shandong Freda Biopharm Co., Ltd.;
Avenabeta glucosan (beta glucan content is greater than 10mg/mL), purchased from Beijing Sanyou Huizhi Biotechnology Co.ltd.
Polydimethylsiloxane and C16-18 alkyl polydimethylsiloxane cross linked polymer, commercial, trade name: Velvesil*DM Silicone (Cas#:756876-51-4), manufacturer: Momentive Performance Materials Japan LLC.
2, the preparation of eye glue:
A phase raw material is placed in to 75-80 ℃ of water-bath and stirs 25-30min, decorating film is dissolved, obtain compound A; Under stirring, in compound A, add C phase raw material, lower the temperature stir 25-30min in 75-80 ℃ of water-bath after, while being cooled to 40-45 ℃, add B phase raw material and stir, add successively D phase raw material and E phase raw material again, stir, temperature stops while being down to 30-35 ℃ stirring, discharging, obtains a glue.In preparation process, add distilled water so that finished product gross mass is 100g.
3, performance test
1) organoleptic properties evaluation
Whether fine and smoothly get glue visual observations outward appearance under room temperature and non-direct sunlight, whether color and luster is bright, with olfactory sensation, differentiates that whether abnormal smells from the patient is pure.
2) test of pH value
Take a glue sample 3g, put into and fill 30mL and remove CO
2the small beaker of deionized water in, at 40 ± 1 ℃, be uniformly dispersed.With the pH meter of having proofreaied and correct, measure the pH value of eye glue solution.
3) heat-resisting, cold-resistant test
2 parts of eye glue samples are placed in respectively to the constant temperature oven of 40 ℃ and the freezer compartment of refrigerator of-10 ℃, and after 24h, taking-up observes whether have oil-water separation phenomenon or obvious character difference after returning to room temperature.
4) hydroscopicity test
Take 2 parts of 5g eye glue, be placed in the weighing botle that diameter is 4cm, under room temperature, in the environment of relative humidity 43%, 75%, place 8h respectively, every 1h, weigh once and the variation of recording sample quality, calculate hydroscopicity.
Wherein mi is the sample quality of i hour, g; m
0for testing front sample quality, g.
5) test of antioxygenic property
Take 0.5g eye glue, after dissolving, proceed to standardize solution in 100mL volumetric flask with pure water, the sample solution that preparation mass concentration is 5mg/mL, measures its non-oxidizability according to following steps.
1. the clearance rate to DPPH free radical
Getting respectively above-mentioned sample solution and amount of substance concentration is 2.00 * 10
-4each 3mL of DPPH ethanol solution of mol/L adds in same tool plug test tube, shakes up, and lucifuge is placed after 30min, with ultraviolet-visible spectrophotometer, measures mixed solution in the absorbance A at 517nm place
i1, measure pure water and the mixed absorbance A of 3mL DPPH ethanol solution of 3mL simultaneously
01with 3mL sample solution and the mixed absorbance A of 3mL dehydrated alcohol
j1, according to formula, calculate clearance rate P
1:
P
1＝[1－(A
i1－A
j1)/A
01]×100%。
2. the clearance rate to OH free radical
Getting 2mL amount of substance concentration is 1.00 * 10
-2salicylic acid-alcoholic solution of mol/L, FeSO
4sample solution after solution and dilution adds in same tool plug test tube, and then adding 2mL amount of substance concentration is 8.8 * 10
-2the H of mol/L
2o
2solution, shakes up rear startup reaction, in 37 ℃ of water-baths, reacts after 30min, measures absorbance A at 510nm place
i2; With 2mL pure water, replace salicylic acid solution to measure absorbance A
j2; With 2mL pure water, replace sample solution to measure absorbance A
02.According to formula, calculate clearance rate P
2:
P
2=[1－(A
i2－A
j2)/A
02]×100%。
3. to O
2 ￣the clearance rate of free radical
Get pH and be 8.2 Tris-HCl buffer solution 5mL in tool plug test tube, in 25 ℃ of water-baths, after preheating 20min, adding successively sample solution 2mL and 0.5mL amount of substance concentration is 5.00 * 10
-3mol/L pyrogallol solution is (with 1.00 * 10
-2the HCl solution preparation of mol/L), shake up immediately, in 25 ℃ of water-baths, react 4min, at 320nm place, measure immediately its absorbance A
i3; With 1.00 * 10
-2the HCl solution 0.5mL of mol/L replaces pyrogallol solution, measures absorbance A
j3; With 2mL pure water, replace sample solution, measure absorbance A
03.According to formula, calculate clearance rate P
3:
P
3=[1－(A
i3－A
j3)/A
03]×100%。
6) eye part skin is tested for a long time
1. skin test on probation for a long time
Testing crew is evenly coated in circumference of eyes by appropriate eye glue every day sooner or later, smears continuously 42 days.Within 42 days, with CBS-1800 type skinanalysis apparatus, skin is near the eyes tested afterwards with using before use respectively.Method of testing is as follows: the camera lens of skinanalysis apparatus is placed near canthus, the knob of twisting camera lens carrys out adjusting focal length, find out picture the most clearly, click and preserve picture, obtain canthus skin picture, analyze the data such as oil content, moisture, pigment, elasticity and collagen fibers of skin of this region skin simultaneously.2. instant compact testing
Observe the skin near the eyes after the clean skin of experimenter and take pictures, after eye is smeared a glue 15min and 30min, continuing observe and take pictures in same area.
4, test result
1) sense organ and physical and chemical testing result
Table 1 sense organ and physical and chemical testing result
2) moisture retention test result
Take the time as abscissa, hydroscopicity be vertical coordinate mapping, the time dependent graph of a relation of hydroscopicity of eye glue sample is shown in Fig. 1.In figure, can find out that hydroscopicity is negative value, illustrating that the long period is placed sample all can dehydration, but owing to having added multiple wetting agent in sample, at 20 ℃, relative humidity is respectively in 75% and 43% environment and places after 8h, hydroscopicity is all less than-2%, and dehydration is slow, illustrates that this glue has good moisture-retaining capacity.
3) antioxidation test result
Eye glue is respectively 83.8%, 60.8%, 50.2% to the clearance rate of DPPH, OH and 3 kinds of free radicals of O2 ￣ when mass concentration is 5mg/mL, illustrates that eye glue has compared with strong anti-oxidation.
4) result on trial analysis
1. long-term result on trial
Two experimenters before use with use the situation of change of this glue skin indices after 42 days in Table 2, the comparison diagram of skin is shown in Fig. 2 near the eyes.Can find out, try out continuously this glue after 42 days, two experimenter's oil content and pigment reductions of skin near the eyes, moisture, elasticity and collagen fiber are improved, and skin all has clear improvement near the eyes.
Table 2 is used before and after eye glue 42 days each index situation of change of skin near the eyes
2. instant compact testing result
Fig. 3 is to be 55 years old trier skin near the eyes before using eye glue and after coating 15min, 30min comparison diagram of taking pictures at an age.As can be seen from the figure, before trying out, skin lines is darker near the eyes, and wrinkle is obvious, and after 15min on probation, wrinkle shoals, and experimenter can obviously feel that skin lifts sense; After 30min, skin lines continues to shoal, and experimenter still can feel and lift effect.
Claims (3)
1. an eye glue, its raw material consists of with E mutually A phase, B phase, C phase, D phase, it is characterized in that each raw material and proportioning are constructed as follows:
Each raw material gross mass is 100g.
2. a preparation method for eye claimed in claim 1 glue, is characterized in that:
A phase raw material is placed in to 75-80 ℃ of water-bath and stirs 25-30min, decorating film is dissolved, obtain compound A; Under stirring, in compound A, add C phase raw material, lower the temperature stir 25-30min in 75-80 ℃ of water-bath after, while being cooled to 40-45 ℃, add B phase raw material and stir, add successively D phase raw material and E phase raw material again, stir, temperature stops while being down to 30-35 ℃ stirring, discharging, obtains a glue.
3. preparation method according to claim 2, is characterized in that:
In preparation process, add distilled water so that finished product gross mass is 100g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410145516.5A CN103932968A (en) | 2014-04-11 | 2014-04-11 | Eye gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410145516.5A CN103932968A (en) | 2014-04-11 | 2014-04-11 | Eye gel and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103932968A true CN103932968A (en) | 2014-07-23 |
Family
ID=51181030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410145516.5A Pending CN103932968A (en) | 2014-04-11 | 2014-04-11 | Eye gel and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434705A (en) * | 2014-12-26 | 2015-03-25 | 青蛙王子(中国)日化有限公司 | Wash-free whitening mask cream for pregnant woman and preparation method of wash-free whitening mask cream |
| CN108125829A (en) * | 2017-12-27 | 2018-06-08 | 广州市澳键丰泽生物科技股份有限公司 | A kind of preparation containing plants essential oil and its preparation method and application |
| CN108272694A (en) * | 2018-04-12 | 2018-07-13 | 广东医科大学 | Ocean is releived the eye mask liquid and preparation method thereof of disposable film for eye |
| CN111973497A (en) * | 2020-08-10 | 2020-11-24 | 合肥卡迪尔生物科技有限公司 | Composition for anti-wrinkle and tightening eye skin care product, anti-wrinkle and tightening eye skin care product and preparation method thereof |
| CN113995700A (en) * | 2021-11-16 | 2022-02-01 | 广州品赫生物科技有限公司 | Anti-wrinkle firming composition and preparation method and application thereof |
-
2014
- 2014-04-11 CN CN201410145516.5A patent/CN103932968A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434705A (en) * | 2014-12-26 | 2015-03-25 | 青蛙王子(中国)日化有限公司 | Wash-free whitening mask cream for pregnant woman and preparation method of wash-free whitening mask cream |
| CN108125829A (en) * | 2017-12-27 | 2018-06-08 | 广州市澳键丰泽生物科技股份有限公司 | A kind of preparation containing plants essential oil and its preparation method and application |
| CN108272694A (en) * | 2018-04-12 | 2018-07-13 | 广东医科大学 | Ocean is releived the eye mask liquid and preparation method thereof of disposable film for eye |
| CN111973497A (en) * | 2020-08-10 | 2020-11-24 | 合肥卡迪尔生物科技有限公司 | Composition for anti-wrinkle and tightening eye skin care product, anti-wrinkle and tightening eye skin care product and preparation method thereof |
| CN113995700A (en) * | 2021-11-16 | 2022-02-01 | 广州品赫生物科技有限公司 | Anti-wrinkle firming composition and preparation method and application thereof |
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Application publication date: 20140723 |
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