CN103585096A - Essence with functions of activating and tightening skin and preparation method thereof - Google Patents
Essence with functions of activating and tightening skin and preparation method thereof Download PDFInfo
- Publication number
- CN103585096A CN103585096A CN201310561225.XA CN201310561225A CN103585096A CN 103585096 A CN103585096 A CN 103585096A CN 201310561225 A CN201310561225 A CN 201310561225A CN 103585096 A CN103585096 A CN 103585096A
- Authority
- CN
- China
- Prior art keywords
- essence
- skin
- face
- compacts
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims description 12
- 230000006870 function Effects 0.000 title abstract description 6
- 230000003213 activating effect Effects 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 12
- 239000012153 distilled water Substances 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 abstract description 32
- 230000003078 antioxidant effect Effects 0.000 abstract description 29
- 230000006378 damage Effects 0.000 abstract description 25
- 239000000284 extract Substances 0.000 abstract description 8
- 241000411851 herbal medicine Species 0.000 abstract description 8
- 230000037303 wrinkles Effects 0.000 abstract description 7
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 241000222336 Ganoderma Species 0.000 abstract description 5
- 150000004676 glycans Chemical class 0.000 abstract description 4
- 229920001282 polysaccharide Polymers 0.000 abstract description 4
- 239000005017 polysaccharide Substances 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 abstract description 3
- 230000002500 effect on skin Effects 0.000 abstract description 3
- 239000000839 emulsion Substances 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 230000004888 barrier function Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 abstract 1
- 229920002498 Beta-glucan Polymers 0.000 abstract 1
- 244000042430 Rhodiola rosea Species 0.000 abstract 1
- 235000003713 Rhodiola rosea Nutrition 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 48
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 34
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 33
- 230000000694 effects Effects 0.000 description 32
- 235000006708 antioxidants Nutrition 0.000 description 31
- 150000003254 radicals Chemical class 0.000 description 26
- 238000012360 testing method Methods 0.000 description 20
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 15
- 229930003268 Vitamin C Natural products 0.000 description 15
- 229930003427 Vitamin E Natural products 0.000 description 15
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 15
- 235000019154 vitamin C Nutrition 0.000 description 15
- 239000011718 vitamin C Substances 0.000 description 15
- 235000019165 vitamin E Nutrition 0.000 description 15
- 229940046009 vitamin E Drugs 0.000 description 15
- 239000011709 vitamin E Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 14
- 102000008186 Collagen Human genes 0.000 description 11
- 108010035532 Collagen Proteins 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 238000002835 absorbance Methods 0.000 description 9
- 230000003064 anti-oxidating effect Effects 0.000 description 9
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 8
- 229920001436 collagen Polymers 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 8
- 229960003180 glutathione Drugs 0.000 description 8
- 230000032683 aging Effects 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 239000012488 sample solution Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000008591 skin barrier function Effects 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 239000009636 Huang Qi Substances 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Natural products O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 235000017471 coenzyme Q10 Nutrition 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 230000037394 skin elasticity Effects 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 241000208340 Araliaceae Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229940123457 Free radical scavenger Drugs 0.000 description 3
- 108010053070 Glutathione Disulfide Proteins 0.000 description 3
- 239000004909 Moisturizer Substances 0.000 description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 description 3
- 108010012715 Superoxide dismutase Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 235000003969 glutathione Nutrition 0.000 description 3
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 3
- 235000019136 lipoic acid Nutrition 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000001333 moisturizer Effects 0.000 description 3
- 239000002516 radical scavenger Substances 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 210000000697 sensory organ Anatomy 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 229960002663 thioctic acid Drugs 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 102000003425 Tyrosinase Human genes 0.000 description 2
- 108060008724 Tyrosinase Proteins 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical class C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- PSFDQSOCUJVVGF-UHFFFAOYSA-N harman Chemical compound C12=CC=CC=C2NC2=C1C=CN=C2C PSFDQSOCUJVVGF-UHFFFAOYSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007908 nanoemulsion Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- -1 peroxy free radical Chemical class 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229940079877 pyrogallol Drugs 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- OCZVHBZNPVABKX-UHFFFAOYSA-N 1,1-diphenyl-2-(2,4,6-trinitrophenyl)hydrazine;ethanol Chemical compound CCO.[O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NN(C=1C=CC=CC=1)C1=CC=CC=C1 OCZVHBZNPVABKX-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 235000002673 Dioscorea communis Nutrition 0.000 description 1
- 241000544230 Dioscorea communis Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 208000035753 Periorbital contusion Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 239000009188 angelicae sinensis extract Substances 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 239000004148 curcumin Chemical class 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Chemical class C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000008472 epithelial growth Effects 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Chemical class 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 229930182490 saponin Chemical class 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Images
Abstract
The invention discloses an emulsion type essence with functions of activating and tightening skin. On the basis of an antioxidant network system, active ingredients such as a polysaccharide skin-tightening agent, oat beta-glucan, hyaluronic acid and the like are added, various Chinese herbal medicine extracts such as rhodiola rosea, ganoderma and the like are compounded, so that the essence has higher efficacy of oxidation resistance, instant tightening and long-acting moisture preservation as well as good repairing effect on skin barrier injury; and with continuous application of the essence, wrinkles become less obvious, and the skin becomes smooth, tight, soft, tender and white.
Description
Technical field
The present invention relates generally to a kind of face alive essence that compacts, and relates in particular to a kind of face alive essence and preparation method thereof that compacts.
Background technology
Mid-term the 1950's, Harman founded old and feeble free radical theory, and this theory thinks that aging is that free radical (being mainly oxygen-derived free radicals) causes harmful attack of cell component.Free radical refers to molecule, atom or the ion with unpaired electron, has active chemical property, easily reacts with other contiguous molecules.In overwhelming majority's reaction, the easy chain-react of free radical a: free-radical generating goes out another one free radical, unpaired electronics is passed to another molecule from a molecule; When two free radicals meet and are combined into electron pair, this chain reaction just can stop.Free radical is human homergy's product, under normal physiological situation, in the dynamic equilibrium of the free radical in human body in continuous generation and elimination.In human body, exist a small amount of free radical not only human body not to be constituted to threat, but also can help to transmit the power that sustains life energy, diminish inflammation, decompose noxious substance etc.If the quantity of people's interior free yl is gathered too much, will cause lipid peroxidation, destroy cellularity, affect the homergy of human body, cause disease, accelerate the process of human senility.
Under normal circumstances, all there is the Antioxidative Defense System of a set of complete removing interior free yl in organism, they can or stop it that oxidation reaction further occurs by direct removing free radical indirectly, to reduce, generate stronger free radical and the intermediate product of toxic action.But with advancing age, the interior generation of body free radical scavenger is that the ability of antioxidant declines gradually, thereby has weakened the defence capability to free radical damage, makes body tissue organ easily impaired, has accelerated the aging of body, causes a series of disease.In order to prevent the generation of this type of phenomenon, can supplement artificially antioxidant, thereby reach defence disease, the object of slow down aging.
Conventional antioxidant comprises that enzyme antioxidant is as superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GSHP), coenzyme (CoQ
10) etc., and non-enzyme antioxidant is as materials such as vitamin A (VA), vitamin C (VC), vitamin E (VE), beta-carotene, alpha-lipoic acid (LA), glutathion (GSH) and zinc, selenium.From plant or Chinese herbal medicine, also can extract the bioactive substance that separation obtains having effect of scavenging radical; as flavonoid, triterpenes, curcumin, Anthraquinones, polysaccharide, Saponin class and compound of containing phenolic hydroxyl structure etc.; this class material is being given full play to the biological effect of antioxidant or free radical scavenger, thereby plays the effect of protection body.
Between antioxidant content, often there is antioxidation synergism.Pluralistic theory thinks, multiple antioxidant is reparative regeneration mutually, forms redox cycle system, thereby makes antioxidant activity significantly be better than single antioxidant.Based on this, the scholars such as the famous professor of Univ California-Berkeley, international free radical chairman Lest doctor Paker of association propose free radical scavenger chain reaction and antioxidant network technology, they,, by the clear and clear and definite old and feeble pattern of latest modern technological Effective Anti of likening to, are considered to revolutionary theory in free radical biomedicine and defying age field.The representative theory that has two special significants in this theory: one is antioxidant series or antioxidant network; Another is the compound chain reaction of antioxidant or the compound chain of antioxidant.
In this antioxidant series, VC, VE, CoQ
10, LA and GSH drafted essence and the core for antioxidant network technology.Its main cause is: the first, and body itself can not produce VC and VE, must from food, obtain.The second, although body can produce CoQ voluntarily
10, LA, GSH, but with advancing age, their levels in vivo obviously decline.The 3rd, these 5 kinds of antioxidants all have wide spectrum, efficient radical scavenging activity, and can mutually supplement each other, Synergistic.The 4th, 5 kinds of antioxidants all respectively have it to be different from the unique effect of other antioxidants.The 5th, in body, between these 5 kinds of antioxidants, exist interaction, and can mutually regenerate, make to have entered each other recirculation, thereby form network, greatly strengthen the function of antioxidant.This network is to resist to take free radical and be the main defence line of the toxic damages of mediation, finally in the process that improves body resistance against diseases and slow down aging, to bring into play special effect in vivo.
Antioxidant network system is the important umbrella that defence organism is crossed presenility, the lost of life; their synergy; can significantly improve biological activity each other, and energy Synergistic, contribute to organism to remove free radical to keep good antioxidation poised state.The principle that five kinds of antioxidants supplement mutually, Synergistic is removed free radical has been illustrated in this antioxidant network system in reaction equation (1)～(10).(1) in formula, LOO is fat peroxy free radical.
LOO·+VE→LOOH+VE· (1)
LOO·+VC→LOOH+VC· (2)
VE·+VC→VE+VC· (3)
VC·+VE→VC+VE· (4)
VE·+GSH→VE+GSSG (5)
VC·+GSH→VC+GSSG (6)
GSSG+CoQ
10H
2→2GSH+CoQ
10 (7)
LA+VC·→VC+LA· (8)
LA+VE·→VE+LA· (9)
LA·+H·→LA (10)
These 5 kinds of antioxidants can also with other antioxidant use in conjunction, as with SOD, natural plant extracts, epithelical cell growth factor (EGF), natural hormone, skin moisturizer, skin-nourishing agent and antitan agent agent etc. can use in conjunction, to play a positive role and complementary advantage, make the more significant effect of anti-aging cosmetics performance.
China is the cradle of Chinese herbal medicine, the application of Chinese herbal medicine aspect the health and beauty history of existing more than 3,000 year.Chinese herbal medicine extract is for cosmetics, can play moisturizing, whitening, sun-proof, antioxidation, slow down aging, promotes skin immunity, promotes the objects such as skin health.At present, there have been on the market many moneys to add the cosmetics of Chinese herbal medicine extracts, but Chinese herbal medicine extract and antioxidant network system are combined and be applied to rarely seen report of research in cosmetics.
Essence, is the superfine product in skin care item, compares with emulsion, cream kind cosmetics, and its composition is exquisite, effect is powerful, effect is remarkable, can play the effect of " comforting outer in peace ".Supplement on the one hand the needed nutrition of skin, moisture, strengthening skin natural resistance, resists the infringement of external environment, allows skin recover as early as possible normal as far as possible; On the other hand, stimulate maintenance and the renewal of accelerating cell, allow skin more become clear, to compact.The contained activity component concentration of essence is the highest in all cosmetics, and general quality is thinner, easily transmits into skin deep layer, is absorbed by the skin better, the amount of playing half merit effect doubly.The present invention be take cosmetics emulsion theory as basis screening matrix formulations, antioxidant network system theory and drug matching is theoretical for instructing the composite of active component, add multiple antioxidant, skin moisturizer, Chinese herbal medicine extract isoreactivity composition, develop the essence having compared with strong anti-oxidation, moisturizing, crease-resistant, the effect of compacting; The sense organ of essence and physical and chemical index, moisture retention, non-oxidizability are tested simultaneously, and the effect after the repairing effect of skin barrier damage and long-term trying out is made an appraisal.
Summary of the invention
The object of the invention is just to provide a kind of face alive essence and preparation method thereof that compacts.
The present invention is achieved by the following technical solutions:
The face essence that compacts, the compact formula of essence of described face alive is:
The compact preparation method of essence of the face of living, comprises the following steps:
Above-mentioned A phase and B are placed in respectively to 75-80 ℃ of water-bath mutually and stir 25-30min, decorating film is dissolved; C is added to A phase, while stirring B is added to; After rapid stirring 25-30min, lower the temperature; While being cooled to 40-45 ℃, respectively D phase, E phase and F being added to and being stirred to evenly; Temperature stops while being down to 30-35 ℃ stirring, and discharging obtains the described face alive essence that compacts.
The compact preparation method of essence of the face of living for making manufactured goods total amount remain 100g, can add appropriate distilled water in the time of cooling in preparation process.
Advantage of the present invention is:
Antioxidant network system is used for to formula, and adds multiple other antioxidants, to bring into play antioxidative synergistic function; Add poly-polysaccharide Firm agent, multiple wetting agent, product is had immediately lift to compact and long-acting moisture-keeping efficacy; Select oil-in-water type matrix formulations as carrier, be convenient to the dissolving of water solublity and fat-soluble various active composition; Part active component adopts nanoemulsions and microcapsule technology, has both been beneficial to the transmission of active component and the absorption of skin, has increased again the stability of product; Soft in formula, essence, parabens, gentle non-stimulated.
VCE in the present invention formula is not affect biological activity and vitamin C derivative that truly can variable color, thereby by enzyme, is decomposed the effect of bringing into play VC after entering skin; It is synthesizing of check melanin cell effectively, prevents and desalinate mottle, can also improve skin gloss simultaneously, repairs Skin Cell active, promotes the formation of collagen protein, has the function that prevents skin aging.Vitamin E acetate is the stable derivatives of VE, and it is decomposed into VE after penetrating skin, thereby produces antioxidant activity, and protection skin exempts from the injury of free radical; It can also promote skin metabolism, improves the elasticity of skin, prevents pigmentation etc.Glutathion not only has non-oxidizability, can also affect Skin Cell tyrosinase activity, check melanin generation, prevents the generation of skin splash.Vitamin A palmitate has anti aging effect, the effect such as anticancer.Resveratrol can be removed free radical, antioxidation, defying age, and the activity of inhibition intracellular tyrosine enzyme, stops melanic formation.Thioctic acid has strong anti-oxidation, has water solublity and fat-soluble concurrently, is easy to skin and absorbs, distinguished for usefulness such as black eye, wrinkle and speckles, can also improve skin dim heavy, careful pore.Ubiquinone
10can effectively remove free radical, prevent skin aging, promote skin metabolism, reduce the generation of wrinkle, also have anti-Pigmented effect.In formula, select to add the nanoemulsions of coenzyme Q10 and thioctic acid, have that particle diameter is little, skin affinity is good and the closed effect on skin, can effectively promote the permeability of active component on skin, the absorption of raising active substance.
Nicotiamide (vitamin B
3) the effectively generation of check melanin cell, skin whitening.Pantothenylol claims again provitamin B
5, be the wetting agent of deep infiltration, can stimulate epithelial growth, promote wound healing, play antiinflammation.Avenabeta glucosan has moisturizing, defying age, wrinkle removal, promotes wound healing, repairs and shines rear damage, desalination cicatrix, the multiple efficacies such as antiallergic antiinflammatory.Hyaluronate sodium is called as optimal wetting agent, and its moisturizing lastingly makes skin tender, smooth; Also can promote the absorption of other active component and nutrient substance, improve the Nutrition and Metabolism of skin, for dermal collagen and elastic fiber synthetic provides good environment, alleviate aging wrinkle vestige, prevent aging.Poly-polysaccharide Firm agent has instantaneous level and smooth skin quality and lifts effect, makes skin plastotype consolidation.
Ganoderma, Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, Radix Rhodiolae all belong to tonification class Chinese medicine, Ganoderma invigorating the spleen and replenishing QI, and Radix Ginseng is mended strengthening spleen and lung, Radix Astragali invigorating QI to consolidate the body surface resistance, Radix Angelicae Sinensis blood circulation promoting and enriching, Radix Rhodiolae promoting blood circulation and hemostasis.According to traditional Chinese medical science compatibility theory, Ganoderma and Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis compatibility, have the effect that increases vigorate qi and replenish the blood.As active component, be added in cosmetics the effect that they are also had nothing in common with each other: Ganoderma, Radix Ginseng extract have antioxidation delay skin aging, promote the multiple efficacies such as skin immunization power; Radix Astragali extract can promote the synthetic of collagen protein, promotes skin elasticity; The activity of Radix Angelicae Sinensis extract energy restraint of tyrosinase, has certain white-skinned face function; Radix Rhodiolae extract has very strong non-oxidizability, can resist the injury of multiple radical pair skin.
The sense organ of essence of the present invention and physical and chemical index all meet China's moisturizer industry standard requirement, there is antioxidation, moisturizing, compact, desalinate the multi-efficiencies such as pigment, repairing effect to skin barrier damage is good, use continuously this work face essence that compacts, wrinkle obviously shoals, skin become water moisten, compact, pale, tender.
Accompanying drawing explanation
Fig. 1 is the face of living compact essence hydroscopicity and time chart;
Horizontal number and time chart before Fig. 2 damages for each index returns to;
Fig. 3 is the face of the living essence skin trial effect cartogram of compacting;
Fig. 4 is skin contrast before and after product beta test, and a is for before on probation, and b is for after on probation.
The specific embodiment
Embodiment 1
The face essence that compacts, the compact formula of essence of described face alive is:
The compact preparation method of essence of the face of living, comprises the following steps:
Above-mentioned A phase and B are placed in respectively to 75-80 ℃ of water-bath mutually and stir 25-30min, decorating film is dissolved; C is added to A phase, while stirring B is added to; After rapid stirring 25-30min, lower the temperature; While being cooled to 40-45 ℃, respectively D phase, E phase and F being added to and being stirred to evenly; Temperature stops while being down to 30-35 ℃ stirring, and discharging obtains the described face alive essence that compacts.
Performance test
Organoleptic properties evaluation
Whether fine and smooth get the face alive essence visual observations granule under room temperature and non-direct sunlight that compacts, whether color and luster uniformity; With olfactory sensation, differentiate that whether abnormal smells from the patient is pure.
The test of pH value
Take the face alive essence sample 3.0g that compacts, put into the small beaker that fills 30mL water, heating for dissolving at 40 ℃.With the pH meter of having proofreaied and correct, measure the pH value of essence aqueous solution.
Centrefuge experiment
The face of the living essence sample that compacts is packed in the centrifuge tube of 10mL, with the centrifugal 30min of 3000r/min, observe and have or not lamination.
Heat-resisting, cold-resistant test
The face of the living essence sample that compacts is positioned in the freezer compartment of refrigerator of the constant temperature oven of 40 ℃ and-10 ℃ and is taken out after 24h, recover to observe whether have layering, precipitation or water outlet phenomenon after room temperature.
Non-oxidizability test
Take the face alive essence 1.00g that compacts, after dissolving with distilled water, proceed to standardize solution in 10mL volumetric flask.As original solution, dilute, preparation mass concentration is 2.00 * 10
-3the sample solution of g/mL, carries out non-oxidizability test.
(1) clearance rate to DPPH free radical
Getting respectively above-mentioned sample solution and amount of substance concentration is 2.00 * 10
-4each 3mL of DPPH ethanol solution of mol/L adds in same tool plug test tube, shakes up, and lucifuge is placed after 30min, with ultraviolet-visible spectrophotometer, measures mixed solution in the absorbance A at 517nm place
i1, measure each extractant and the mixed absorbance A of 3mLDPPH solution of 3mL simultaneously
01with 3mL sample solution and the mixed absorbance A of 3mL dehydrated alcohol
j1, according to formula, calculate clearance rate P
1:
P
1＝[1－(A
i1－A
j1)/A
01]×100%
(2) clearance rate to OH free radical
Getting 2mL amount of substance concentration is 1.00 * 10
-2the salicylic acid solution of mol/L, FeSO
4sample solution after solution and dilution adds in same tool plug test tube, and then adding 2mL amount of substance concentration is 8.80 * 10
-2the H of mol/L
2o
2solution, shakes up rear startup reaction, in 37 ℃ of water-baths, reacts after 30min, measures absorbance A at 510nm place
i2; With 2mL distilled water, replace salicylic acid solution to measure absorbance A
j2; With 2mL distilled water, replace sample solution to measure absorbance A
02.According to formula, calculate clearance rate P
2:
P
2=[1－(A
i2－A
j2)/A
02]×100%
(3) to O
2 ￣the clearance rate of free radical
Get pH and be 8.2 Tris-HCl buffer solution 5mL in tool plug test tube, in 25 ℃ of water-baths, after preheating 20min, adding successively sample solution 2mL and 0.5mL amount of substance concentration is 5.00 * 10
-3mol/L pyrogallol hydrochloric acid solution, shakes up immediately, in 25 ℃ of water-baths, reacts 4min, measures immediately its absorbance A at 320nm place
i3; With 1.00 * 10
-2the HCl solution 0.5mL of mol/L replaces pyrogallol hydrochloric acid solution, measures absorbance A
j3; With 2mL distilled water, replace above-mentioned different sample solutions, measure absorbance A
03.According to formula, calculate clearance rate P
3:
P
3=[1－(A
i3－A
j3)/A
03]×100%
Hydroscopicity test
Take the 5.00g face essence that compacts of living, be placed in the weighing botle that diameter is 4cm, at room temperature, be placed on 8h in the environment of relative humidity 43%, 75%, the variation that weighs and record each sample quality every 1h, calculating hydroscopicity.
M wherein
nfor placing sample quality after n hour, g; m
0for placing front testing sample quality, g.
Skin experiment on probation
(1) the repairing effect test to skin barrier damage
Select 20 people as tester, be divided into 2 groups.With inboard arm 3 * 3cm
2place, for position on probation, cleans, and with skinanalysis apparatus, tests.Test with 50% alcoholic solution wiping 5min, after first group of indoor standing 20min of tester, smear sample, with skinanalysis apparatus test, every 1h test 1 time, observe trial effect afterwards immediately.Alcoholic solution wiping is complete is left intact with 50% for second group of tester, every 1h test 1 time, observation of nature repairing effect.
(2) skin is tested for a long time
Select 20 people as tester, the mean age was 35 one full year of life, the on probation face of living of the face essence that compacts, and respectively used 1 time every day sooner or later, shares 42 days, with skinanalysis apparatus test, observes trial effect week about.
Test result
Sense organ and physical and chemical index measurement result
Non-oxidizability
The face of the living essence that compacts is 2.00 * 10 in mass concentration
-3during g/mL to DPPH, OH and O
2 ￣the clearance rate of 3 kinds of free radicals is respectively 60.4%, 81.3%, 70.3%, illustrates that the face of the living essence that compacts has compared with strong anti-oxidation;
The compact moisture retention of essence of the face of living
Fig. 1 is that face alive is compacted essence at ambient temperature, moisturizing rate and time chart when relative humidity is respectively 43% and 75%.Can find out, under room temperature condition, when relative humidity is 75%, the face of living is compacted the decline of essence hydroscopicity slowly, is only-0.43% after 8h; When relative humidity is 43%, the face of the living essence hydroscopicity that compacts declines during compared with relative humidity 75% soon, but is only also-0.61%.Can find out, the compact moistening effect of essence of the face of living is better.
Repairing effect test to skin barrier damage
Ethanol can be partly dissolved Stratum corneum lipids composition, destroys original structure, causes barrier function damage, and main manifestations is skin oil content, moisture, elasticity, collagen content decline.Fig. 2 is that first group of subject uses the face alive essence that compacts to smear after damage location, and each index returns to number and the time chart of level before damage.After smearing, there is 6 experimenters' oil content content to recover the front normal level of damage, normal level before whole experimenters' oil content recovery damage after 1h; After smearing, there is 7 experimenters' moisture to recover the front normal level of damage, normal level before whole experimenters' moisture recovery damage after 2h; After smearing, there are 3 experimenter's skin elasticitys to return to the front normal level of damage, after 8h, have 7 experimenter's skin elasticitys to return to the front normal level of damage; After smearing, there are 4 collagen contents to return to the front normal level of damage, after 8h, have 6 experimenter's collagen contents to return to the front normal level of damage.Second group of subject repairs naturally, and before after 8h, oil content, moisture, elasticity, collagen content return to damage, the number of level is respectively 7,4,2,2.Can find out, smearing the face alive injured skin after essence that compacts all repairs to some extent, all experimenters' oil content and moisture just can return to the front normal level of damage at short notice, skin elasticity and collagen content recover number also all more than 6 people, be significantly higher than nature repairing effect, illustrate that the face of the living essence that compacts is more remarkable to the repairing effect of skin barrier damage.
Skin is tested for a long time
With advancing age, the moisture of human body skin, elasticity, collagen fabric content all can constantly decline, and hydropenia will be destroyed the water oil balance of skin, causes skin to secrete more oil content, pigment content with advancing age, sun exposure etc., also can increase gradually.Moisture, oil content, elasticity, collagen protein and pigment content that subject's face of living on probation is compacted in the skin of essence front and back are tested, and take and try out natural law as abscissa, and each index variation number of skin is vertical coordinate mapping.As seen from Figure 3,20 subject's face of living on probation are compacted after essence, the vicissitudinous number of each index.Along with the prolongation of natural law on probation, the tested number that moisture, elasticity, collagen content improve increases gradually, and the number that after 42 days, these 3 indexs are improved is respectively 18,12,14; And oil content and pigment content be along with natural law on probation extends, the subject who reduces gradually also constantly increases, and after 42 days, these 2 indexs are compared the number reducing before on probation and are respectively 17 and 10.70% subject reaction, skin soft, smooth, the water profit that becomes that can significantly feel for first week on probation, tries out after 42 days continuously, and 85% experimenter can significantly see the variation of skin.Fig. 4 be the experimenter of wherein 44 one full year of life, dry skin on probation before and the comparison diagram of skin after 42 days on probation.Can find out, the skin texture after 42 days on probation obviously shoals, and it is pale glossy that skin also becomes.Test result shows, the face of the living on probation essence wrinkle that compacts obviously shoals continuously, the skin water profit, pale, soft flexible that becomes.
Claims (3)
1. the face of the living essence that compacts, is characterized in that the compact formula of essence of described face alive is:
2. the face alive as claimed in claim 1 preparation method for essence of compacting, is characterized in that comprising the following steps:
Above-mentioned A phase and B are placed in respectively to 75-80 ℃ of water-bath mutually and stir 25-30min, decorating film is dissolved; C is added to A phase, while stirring B is added to; After rapid stirring 25-30min, lower the temperature; While being cooled to 40-45 ℃, respectively D phase, E phase and F being added to and being stirred to evenly; Temperature stops while being down to 30-35 ℃ stirring, and discharging obtains the described face alive essence that compacts.
3. a kind of face of living according to claim 2 preparation method of essence of compacting, is characterized in that in preparation process, for making manufactured goods total amount remain 100g, in the time of cooling, can adding appropriate distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310561225.XA CN103585096B (en) | 2013-11-12 | 2013-11-12 | A kind of face of living essence and preparation method thereof that compacts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310561225.XA CN103585096B (en) | 2013-11-12 | 2013-11-12 | A kind of face of living essence and preparation method thereof that compacts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103585096A true CN103585096A (en) | 2014-02-19 |
| CN103585096B CN103585096B (en) | 2016-05-25 |
Family
ID=50075553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310561225.XA Active CN103585096B (en) | 2013-11-12 | 2013-11-12 | A kind of face of living essence and preparation method thereof that compacts |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103585096B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473791A (en) * | 2014-12-10 | 2015-04-01 | 唯美度科技（北京）有限公司 | Breathable double-effect fresh protective emulsion |
| CN104688553A (en) * | 2015-02-06 | 2015-06-10 | 深圳唯美度生物科技有限公司 | Emulsion containing lipoic acid and preparation method of emulsion |
| CN104958240A (en) * | 2015-07-31 | 2015-10-07 | 桂林市宏旭生物科技有限公司 | Freckle expelling facial mask and preparation method thereof |
| CN104958242A (en) * | 2015-07-31 | 2015-10-07 | 桂林市宏旭生物科技有限公司 | Anti-ultraviolet mask liquid and preparation method thereof |
| CN104971029A (en) * | 2015-07-31 | 2015-10-14 | 桂林市宏旭生物科技有限公司 | Whitening mask and preparation method thereof |
| CN104983646A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Night maintenance mask solution and preparation method thereof |
| CN105434266A (en) * | 2015-12-20 | 2016-03-30 | 青岛海特新蓝生物科技有限公司 | Whitening cosmetic containing rhodiola-rosea extractive, ginseng extractive and ganoderma-lucidum extractive |
| CN107095828A (en) * | 2017-07-03 | 2017-08-29 | 四川省中医药科学院 | A kind of daily chemical product composition with skin barrier repair function and its production and use |
| CN107137260A (en) * | 2017-04-05 | 2017-09-08 | 北海市韩能生物科技有限公司 | Toner |
| CN107383167A (en) * | 2017-08-07 | 2017-11-24 | 温州千瑞生物科技有限公司 | Antioxidation active peptides and application thereof |
| CN107998027A (en) * | 2017-12-24 | 2018-05-08 | 姚佑灿 | A kind of antiradiation injury repairs breast |
| CN108354869A (en) * | 2018-04-28 | 2018-08-03 | 广东巴松那生物科技有限公司 | A kind of essence lotion and preparation method thereof that fixes of the coreopsis tinctoria extract containing Tianshan Mountains |
| CN109394671A (en) * | 2018-12-18 | 2019-03-01 | 韩孝 | The composition and its preparation method and application of albumen bracket firm skin |
| CN111514173A (en) * | 2019-02-01 | 2020-08-11 | 宝龄富锦生技股份有限公司 | Composition for repairing skin barrier and use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078283A (en) * | 2011-01-25 | 2011-06-01 | 朱爱民 | Traditional Chinese medicinal nutritional emulsifiable paste for whitening skin and removing speckles |
-
2013
- 2013-11-12 CN CN201310561225.XA patent/CN103585096B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078283A (en) * | 2011-01-25 | 2011-06-01 | 朱爱民 | Traditional Chinese medicinal nutritional emulsifiable paste for whitening skin and removing speckles |
Non-Patent Citations (2)
| Title |
|---|
| SEPPIC: "SIMULGEL EG", 《安全技术说明书》, 24 November 2010 (2010-11-24) * |
| 丁克祥: "国际抗氧化网络理论在抗衰老化妆品研制中的应用", 《第十届东南亚地区医学美容学术大会论文汇编》, 1 August 2006 (2006-08-01) * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473791A (en) * | 2014-12-10 | 2015-04-01 | 唯美度科技（北京）有限公司 | Breathable double-effect fresh protective emulsion |
| CN104688553A (en) * | 2015-02-06 | 2015-06-10 | 深圳唯美度生物科技有限公司 | Emulsion containing lipoic acid and preparation method of emulsion |
| CN104958240A (en) * | 2015-07-31 | 2015-10-07 | 桂林市宏旭生物科技有限公司 | Freckle expelling facial mask and preparation method thereof |
| CN104958242A (en) * | 2015-07-31 | 2015-10-07 | 桂林市宏旭生物科技有限公司 | Anti-ultraviolet mask liquid and preparation method thereof |
| CN104971029A (en) * | 2015-07-31 | 2015-10-14 | 桂林市宏旭生物科技有限公司 | Whitening mask and preparation method thereof |
| CN104983646A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Night maintenance mask solution and preparation method thereof |
| CN105434266A (en) * | 2015-12-20 | 2016-03-30 | 青岛海特新蓝生物科技有限公司 | Whitening cosmetic containing rhodiola-rosea extractive, ginseng extractive and ganoderma-lucidum extractive |
| CN107137260A (en) * | 2017-04-05 | 2017-09-08 | 北海市韩能生物科技有限公司 | Toner |
| CN107095828A (en) * | 2017-07-03 | 2017-08-29 | 四川省中医药科学院 | A kind of daily chemical product composition with skin barrier repair function and its production and use |
| CN107095828B (en) * | 2017-07-03 | 2020-08-11 | 四川省中医药科学院 | Daily chemical product composition with skin barrier repair function and preparation method and application thereof |
| CN107383167A (en) * | 2017-08-07 | 2017-11-24 | 温州千瑞生物科技有限公司 | Antioxidation active peptides and application thereof |
| CN107998027A (en) * | 2017-12-24 | 2018-05-08 | 姚佑灿 | A kind of antiradiation injury repairs breast |
| CN108354869A (en) * | 2018-04-28 | 2018-08-03 | 广东巴松那生物科技有限公司 | A kind of essence lotion and preparation method thereof that fixes of the coreopsis tinctoria extract containing Tianshan Mountains |
| CN109394671A (en) * | 2018-12-18 | 2019-03-01 | 韩孝 | The composition and its preparation method and application of albumen bracket firm skin |
| CN111514173A (en) * | 2019-02-01 | 2020-08-11 | 宝龄富锦生技股份有限公司 | Composition for repairing skin barrier and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103585096B (en) | 2016-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103585096B (en) | A kind of face of living essence and preparation method thereof that compacts | |
| CN105769683B (en) | A kind of anti-oxidant moisturizing sleep mask containing peony seed oil and preparation method thereof | |
| CN102973486B (en) | Nourishing youth-keeping facial cleanser and preparation method thereof | |
| CN105168054A (en) | Mask capable of supplementing water, whitening and removing wrinkles and preparation method of mask | |
| CN103860453B (en) | A kind of face of living is compacted emollient cream and preparation method thereof | |
| CN106176556A (en) | A kind of removing acnes and controlling oil whitening cream | |
| CN104983647A (en) | Deep restoration mask and making method thereof | |
| CN107296764B (en) | Cream and preparation method thereof | |
| CN104983646A (en) | Night maintenance mask solution and preparation method thereof | |
| CN103599062A (en) | Eye cream and preparation method thereof | |
| CN109044941B (en) | Skin firming, nourishing and moisturizing composition and preparation method and application thereof | |
| CN104983666A (en) | Repair and regeneration mask product and preparation method thereof | |
| CN103989601A (en) | Shining, moisturizing and skin-finishing cream and preparation method thereof | |
| CN103494719B (en) | Preparation method of anti-aging cream | |
| KR101915655B1 (en) | Cosmetic composition containing Croton Lechleri resin extract | |
| CN104434642B (en) | A kind of after-sun restorative skin whitening, moisturizing condensation and preparation method thereof | |
| CN108685728A (en) | A kind of eye cream and preparation method thereof | |
| CN113730272B (en) | Eye-protecting patch with eye fatigue relieving effect and preparation method thereof | |
| CN111544343B (en) | Whitening emulsion rich in rosewood essential oil liposome and preparation method and application thereof | |
| CN104248548A (en) | Plant extract-containing oxidation-resistant essence | |
| KR101862039B1 (en) | A cosmetic composition containing spicule powder and natural complex extract stabilized in nanoliposome | |
| CN108553365A (en) | A kind of apple myofilament sliding surface film and preparation method thereof | |
| CN110801412B (en) | Sebum bionic composition, application thereof and cosmetics | |
| CN104473798A (en) | Pseudo-ginseng skin toner and preparation method thereof | |
| CN111870541A (en) | Herbal whitening compound composition, mask and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 237009 Anhui Lu'an Economic Development Zone Science and Technology Innovation Service Center Co-patentee after: ANHUI University Patentee after: Anhui Dan Dan materia medica Technology Co.,Ltd. Address before: 237009 Anhui Lu'an Economic Development Zone Science and Technology Innovation Service Center Co-patentee before: Anhui University Patentee before: LU'AN DANHUANG BIOTECHNOLOGY Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220922 Address after: No.13, 3rd floor, building 1, No.1, Tidu street, Qingyang District, Chengdu, Sichuan 610000 Patentee after: Chengdu yishenrui Technology Co.,Ltd. Address before: 237009 Anhui Lu'an Economic Development Zone Science and Technology Innovation Service Center Patentee before: Anhui Dan Dan materia medica Technology Co.,Ltd. Patentee before: ANHUI University Effective date of registration: 20220922 Address after: Room 1738, Area B, Floor 1-2, No. 6395, Hutai Road, Baoshan District, Shanghai, 200000 Patentee after: Yuanyang International Trade (Shanghai) Co.,Ltd. Address before: No.13, 3rd floor, building 1, No.1, Tidu street, Qingyang District, Chengdu, Sichuan 610000 Patentee before: Chengdu yishenrui Technology Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Room 1738, Area B, Floor 1-2, No. 6395, Hutai Road, Baoshan District, Shanghai, 200000 Patentee after: Shanghai Yanglan Biotechnology Co.,Ltd. Address before: Room 1738, Area B, Floor 1-2, No. 6395, Hutai Road, Baoshan District, Shanghai, 200000 Patentee before: Yuanyang International Trade (Shanghai) Co.,Ltd. |