CN108125829A - A kind of preparation containing plants essential oil and its preparation method and application - Google Patents
A kind of preparation containing plants essential oil and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
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Abstract
The invention discloses a kind of preparations containing plants essential oil and its preparation method and application.Preparation of the present invention containing plants essential oil is included as follows according to the component of mass percentage：Hyaluronic acid 0.2~0.5%, oat beta glucan 0.5~0.8%, the methyl hydroxybenzoate 2~3.5% of 10wt%, Phenoxyethanol 0.5~0.8%, the sodium hydroxy methyl glycinate 0.5~1% of 10wt%, propylene glycol 3~5%, water 40~48.5%, the Acritamer 940 20~30% of 0.5wt%, plants essential oil 10~15% and PEG 40 4~5.5%.Preparation of the present invention containing plants essential oil can be used for preparing eye-care product, has and moistens moisturizing, reduce livid ring around eye, crease-resistant Firm, improve skin quality and other effects, has good market prospects.
Description
Technical field
The invention belongs to cosmetic technical field, it is more particularly related to which a kind of have a variety of eye-care work(
Preparation containing plants essential oil of energy and preparation method thereof.
Background technology
The live load weight of eye skin, fatiguability.Normal work will blink 10,000 times eyes daily, this is a series of dynamic
To make that eye muscle and its skin careful around is made to receive greatest pressure, eyes are bigger, and span when blinking is also bigger,
Therefore easily fatigue and aging.In addition, eye skin is the most thin position of human skin, the thickness of eye epidermis and corium only has
0.25~0.55 millimeter, and eye part skin collagen and elastomer distribution are seldom, lack muscle support, subcutaneously almost without
Sebaceous glands is distributed with sweat gland, therefore eye part skin is susceptible to drying, aging, generates the problems such as wrinkle, livid ring around eye and pouch.Most
Afterwards, emotional change, the ethnic colour of skin, shortage nutrition, endocrine imbalance and metabolic disorder etc. are to cause eye circumference skin old
A series of internal causes changed.
There is the eye skin-protection product of numerous kinds currently on the market, including eye mask, eye glue, eye gel, eye sticker, eye cream
Deng, but many products all exist and absorb bad, the problems such as functional effect unobvious or even grease grain, allergy etc. can be caused bad
Reaction.
Essential oil, person " liquid golden " due to its distinctive natural characteristic and efficacy effect, obtain in cosmetics field
To the favor of numerous consumers.Plants essential oil has that molecular structure is minimum, can rapid osmotic skin, the advantages of absorptivity is high.
Test data shows that lower 1 millimeter of essential oil infiltration face superficial skin only needs 30~60 seconds, and absorbed power be up to 90% with
On.Therefore, one new direction of consumer can be given using plants essential oil exploitation eye skin-protection product.Therefore, essential oil addition type
Pure natural plant essential oil in skin care item can not only go directly deep skin, can more enter blood of human body and lymphatic system, outside interior tune
It supports, realizes the effect for the treatment of both manifestation and root cause of disease.In addition, essential oil contains multiple biological activities ingredient, there is anti-oxidant, anti-aging, antibacterial resists
Allergy and other effects.
Invention content
It is an object of the invention to：Overcome existing eye skin-protection product is existing to absorb bad, easy generation fat granule etc.
Problem, provide it is a kind of it is can quickly absorbing, have multiple eye-care effect containing the preparation of plants essential oil and its preparation side
Method and application.
In order to achieve the above-mentioned object of the invention, the present invention provides a kind of preparation containing plants essential oil, including pressing as follows
According to the component of mass percentage：Hyaluronic acid 0.2~0.5%, avenabeta glucosan 0.5~0.8%, 10wt% oxybenzene first
Ester 2~3.5%, Phenoxyethanol 0.5~0.8%, the sodium hydroxy methyl glycinate 0.5~1% of 10wt%, propylene glycol 3~5%, water
40~48.5%, the Acritamer 940 20~30% of 0.5wt%, plants essential oil 10~15% and PEG-40 4~5.5%；
Wherein, the plants essential oil contains as follows according to the component of mass percent meter：Rosa Damascana 0.1~0.5%, ox
Oily fruit oil 2~8%, Java Cananga Oil 3~5%, jojoba oil 1~3%, Sweet Almond Oil 2~8%, dihydrojasmonate 0.01
~0.03%, indoles 0.01~0.02%, surplus are Glycerin, mixed triester with caprylic acid capric acid.
In order to achieve the above-mentioned object of the invention, the present invention also provides the preparation method of the above-mentioned preparation containing plants essential oil,
It includes the following steps：
(1) preparation of oil phase：Plants essential oil and PEG-40 are uniformly mixed, oil phase is obtained after filtering；
(2) preparation of water phase：The Acritamer 940 of hyaluronic acid, avenabeta glucosan, 0.5wt% are added to deionization
In water, 90~100 DEG C are heated with stirring to, sterilize 20min, is cooled to room temperature, water phase is obtained after filtering；
(3) it emulsifies：Oil phase obtained by step (1) is first added to emulsification pot, then water phase obtained by step (2) is added to emulsification
Pot, high-speed stirred, after oil phase is sufficiently mixed into finely dispersed emulsion with water phase, add 10wt% methyl hydroxybenzoate,
The sodium hydroxy methyl glycinate of Phenoxyethanol and 10wt%, stirs evenly；
(4) step (3) products therefrom is aged at least 48h, obtains the preparation containing plants essential oil；
Wherein, the Acritamer 940 of the 0.5wt% dilutes to obtain with deionized water in advance, the oxybenzene first of the 10wt%
Ester dilutes to obtain with propylene glycol in advance, and the sodium hydroxy methyl glycinate of the 10wt% dilutes to obtain with deionized water in advance.
Preparation of the present invention containing plants essential oil can specifically be prepared into the products such as eye cream, for eye-care.
Therefore, the present invention also provides a kind of eye-care product, above-mentioned contain plant essence it includes as active component
The preparation of oil.
Relative to the prior art, the present invention has the advantages that：
(1) preparation of the invention containing plants essential oil is without the substances such as heavy metal, alcohol, hormone, mineral oil and pigment, choosing
The raw material taken is largely food-grade, and formula is soft, has no stimulation of the skin；
(2) present invention is added to the plants essential oil of unique formula, and plants essential oil molecular structure is minimum, being capable of rapid osmotic flesh
Skin, go directly deep skin, can more enter blood of human body and lymphatic system, be supported outside interior tune, realize the effect for the treatment of both manifestation and root cause of disease, had very
Good beautifying skin-protection function, and fragrance is harmonious, fresh and clean.
Description of the drawings
Fig. 1 is the DPPH free radical scavenging abilities of the preparation of the invention containing plants essential oil.
Fig. 2 is the preparation of the invention containing plants essential oil to tyrosinase inhibition rate result.
Specific embodiment
In order to be more clear the purpose of the present invention, technical solution and advantageous effects, with reference to embodiments, to this
Invention is further elaborated.It should be understood that the embodiment described in this specification is just for the sake of this hair of explanation
It is bright, be not intended to limit the present invention, parameter, ratio of embodiment etc. can adaptation to local conditions make a choice and substance had no to result
It influences.
In following embodiment, unless otherwise instructed, each raw material is market purchase.
Embodiment 1
Prepare the preparation containing plants essential oil：
Raw material：
Hyaluronic acid 0.2wt%, the methyl hydroxybenzoate 3.5wt% of avenabeta glucosan 0.5wt%, 10wt%, Phenoxyethanol
The sodium hydroxy methyl glycinate 1wt% of 0.8wt%, 10wt%, propylene glycol 5wt%, the Acritamer 940 of water 48wt%, 0.5wt%
(water dilution) 27wt%, plants essential oil 10wt%, PEG-40 4wt%.Wherein, the methyl hydroxybenzoate of 10wt% is dilute using propylene glycol
It releases to obtain, the sodium hydroxy methyl glycinate of 10wt% and the Acritamer 940 of 0.5wt% dilute to obtain using deionized water.
Wherein, plants essential oil contains as follows according to the component of mass percent meter：Rosa Damascana 0.1%, galam butter
2%th, Java Cananga Oil 3%, jojoba oil 1%, Sweet Almond Oil 2%, dihydrojasmonate 0.01%, indoles 0.01%, surplus
For Glycerin, mixed triester with caprylic acid capric acid, 100% is supplied.
It is prepared as follows：
The preparation of oil phase：Plants essential oil and PEG-40 are mixed, stirring is uniformly mixed it, for use；
The preparation of water phase：By water-soluble material hyaluronic acid, avenabeta glucosan, the Acritamer 940 addition of 0.5wt% is gone
In ionized water, 90~100 DEG C are heated with stirring to, keeps sterilizing for 20 minutes, is subsequently cooled to room temperature, for use；
Emulsification：After oil phase and Aqueous Phase Raw Material filtering, added in emulsification pot according to the sequence of water after first oil, carry out high-speed stirring
Mix, after oil, after Aqueous Phase Raw Material is sufficiently mixed into finely dispersed emulsion, then add the methyl hydroxybenzoate of 10wt%, Phenoxyethanol and
The sodium hydroxy methyl glycinate of 10wt%, stirs evenly, that is, completes emulsification procedure；
It is aged and filling：It is discharged in storage container, is placed in ageing no less than 48 hours between storage cream, through after the assay was approved,
It prepares, finally carries out filling according to the customary preparation methods of eye cream.
Embodiment 2
Prepare the preparation containing plants essential oil：
Raw material：
Hyaluronic acid 0.5wt%, the methyl hydroxybenzoate 3.0wt% of avenabeta glucosan 0.8wt%, 10wt%, Phenoxyethanol
The sodium hydroxy methyl glycinate 0.6wt% of 0.6wt%, 10wt%, propylene glycol 4wt%, the Acritamer 940 of water 44wt%, 0.5wt%
(water dilution) 30wt%, plants essential oil 12wt%, PEG-40 4.5wt%.Wherein, the methyl hydroxybenzoate of 10wt% uses propylene glycol
Dilution obtains, and the sodium hydroxy methyl glycinate of 10wt% and the Acritamer 940 of 0.5wt% dilute to obtain using deionized water.
Wherein, plants essential oil contains as follows according to the component of mass percent meter：Rosa Damascana 0.5%, galam butter
8%th, Java Cananga Oil 5%, jojoba oil 3%, Sweet Almond Oil 8%, dihydrojasmonate 0.03%, indoles 0.02%, surplus
For Glycerin, mixed triester with caprylic acid capric acid, 100% is supplied.
Wherein, Rosa Damascana of the Rosa Damascana disclosed in using the patent of invention of Patent No. 201210235667.0.
It is prepared as follows：
The preparation of oil phase：Plants essential oil and PEG-40 are mixed, stirring is uniformly mixed it, for use；
The preparation of water phase：By water-soluble material hyaluronic acid, avenabeta glucosan, the Acritamer 940 addition of 0.5wt% is gone
In ionized water, 90~100 DEG C are heated with stirring to, keeps sterilizing for 20 minutes, is subsequently cooled to room temperature, for use；
Emulsification：After oil phase and Aqueous Phase Raw Material filtering, added in emulsification pot according to the sequence of water after first oil, carry out high-speed stirring
Mix, after oil, after Aqueous Phase Raw Material is sufficiently mixed into finely dispersed emulsion, then add the methyl hydroxybenzoate of 10wt%, Phenoxyethanol and
The sodium hydroxy methyl glycinate of 10wt%, stirs evenly, that is, completes emulsification procedure；
It is aged and filling：It is discharged in storage container, is placed in ageing no less than 48 hours between storage cream, through after the assay was approved,
It prepares, finally carries out filling according to the customary preparation methods of eye cream.
Experimental example 1
Essential oil Transdermal absorption is tested：
Sample:Test A groups：The Rosa Damascana prepared using the patent of invention of Patent No. 201210235667.0.
Test B groups：Commercially available Rosa Damascana.
Test C groups：Plants essential oil used herein：Rosa Damascana, galam butter, Java Cananga Oil, jojoba oil, dessert almond
Oil, mass ratio 0.1:2:3:1:2, wherein, Rosa Damascana is prepared using the patent of invention of Patent No. 201210235667.0
Rosa Damascana.
Test D groups：Plants essential oil with testing C group same amounts is prepared using commercially available Rosa Damascana.
Test method：(1) prepared by isolated skin
By SD rats, normally raising is anaesthetized after 1 day, and neck takes blood lethal, removes lower abdomen skin, then removes subcutaneous fat
It with mucous membrane, and is cleaned with physiological saline, until washing lotion without white opacity, is immersed in suitable physiological saline, is blotted with filter paper
Skin surface moisture, chooses that size is appropriate and unmarred skin, is laid on aluminium foil, wraps, is placed in refrigerator (- 20 DEG C) and refrigerates
It preserves, physiological saline naturally to thaw before experiment.
(2) penetrating absorption operates
The skin prepared is separately fixed on Franz diffusion cell receiving ports, the cuticula of skin is upward, reception tank
Volume is 6.5ml, and the area effectively permeated is 3.14cm2, the corium side of skin contacts with reception tank, empties bubble, receive
Liquid is 50% ethyl alcohol-physiological saline, and the outer water-bath cycle (37 ± 0.5) DEG C of Franz diffusion cells, 200rmp constant speed is stirred in reception tank
It mixes.
Rat transdermal experiment is after system temperature is constant, for gently adding in 1.0ml essential oil smaples in medicine pond respectively.Constant speed is stirred
It mixes and starts timing.Receiving liquid 1.0ml is extracted from probe tube respectively at 2,4,8h, isometric isothermal is added in time after every sub-sampling
50% ethyl alcohol-physiological saline and exclude the bubble in reception tank.Acquire acceptance pool sample.The receiving liquid sample of acquisition is placed in tool
It fills in teat glass, cryogenic seal is kept in dark place, interior for 24 hours to have surveyed.It is carried out after 0.45 μm of filtering with microporous membrane of sample liquid via hole diameter
Gas chromatography mass spectrometry measures analysis.According to working curve calculate essential oil concentration, and according to the following formula shown in unit of account area add up
Transit dose (Qn)
C in formulanThe plants essential oil concentration (μ g/ml) measured for n-th of sample point；V is receiving liquid volume (15ml)；Ci
The plants essential oil concentration (μ g/ml) measured for i-th of sample point；Vi is sample volume (1.0ml)；A is infiltrating area
(3.14cm2)。
(3) Transdermal absorption is tested
Solution prepares precision weighing experiment A groups~D group essential oil 1.00g respectively, is placed in the brown volumetric flask of 100m L, adds
Enter 50% ethyl alcohol-normal saline dilution to scale, shake up, the sample solution of concentration 10.0mg/ml is made as transdermal sample liquid,
Each concentration gradient does three groups of parallel tests.
The skin permeation test in vitro of essential oil the results are shown in Table 1, and result of the test shows that Four Plants essential oil all has higher skin
Permeability wherein the percutaneous absorbability of the plants essential oil employed in the present invention is best, passes through Patent No.
Its percutaneous permeability of 201210235667.0 Rosa Damascana of patent of invention preparation takes second place, the plants essential oil of commercially available same composition
Mixture percutaneous absorbability third, the percutaneous absorbability of commercially available Rosa Damascana are worst.
The unit area of the different essential oils of table 1 adds up transit dose
2 DPPH radicals scavengings of experimental example are tested
Human body is with advancing age and long-term environmental stimuli can all generate free radicals, and free radical is generally acknowledged in the world makes
People generates the reason of aging, meanwhile, it is obscure unglazed that free radical also results in skin, the problems such as microgroove occurs.DPPH is a kind of steady
The fixed free radical centered on nitrogen, has maximum absorption band under wavelength.Substance with oxidation resistance can make free radical also
Original, system are converted into pink colour or yellow from bluish violet.With the progress of reaction, the reduction of number of free radical, system is under wavelength
Light absorption value also with reduction.
Test A groups:The product prepared according to embodiment 1.
Test B groups:The product prepared according to embodiment 2.
Test C groups：This group of test products composition is as follows：Hyaluronic acid 0.3wt%, avenabeta glucosan 0.7wt%,
The methyl hydroxybenzoate 3.0wt% of 10wt%, the sodium hydroxy methyl glycinate 0.8wt% of Phenoxyethanol 0.6wt%, 10wt%, propylene glycol
Acritamer 940 (water dilution) 30wt%, Rosa Damascana 12.5wt%, PEG-40 of 4wt%, water 43wt%, 0.5wt%
5.1wt%.Wherein, the methyl hydroxybenzoate of 10wt% dilutes to obtain using propylene glycol, the sodium hydroxy methyl glycinate of 10wt% and
The Acritamer 940 of 0.5wt% dilutes to obtain using deionized water.Wherein, Rosa Damascana uses Patent No.
201210235667.0 patent of invention disclosed in Rosa Damascana.
And it is prepared as follows：
The preparation of oil phase：Plants essential oil and PEG-40 are mixed, stirring is uniformly mixed it, for use；
The preparation of water phase：By water-soluble material hyaluronic acid, avenabeta glucosan, the Acritamer 940 addition of 0.5wt% is gone
In ionized water, 90~100 DEG C are heated with stirring to, keeps sterilizing for 20 minutes, is subsequently cooled to room temperature, for use；
Emulsification：After oil phase and Aqueous Phase Raw Material filtering, added in emulsification pot according to the sequence of water after first oil, carry out high-speed stirring
Mix, after oil, after Aqueous Phase Raw Material is sufficiently mixed into finely dispersed emulsion, then add the methyl hydroxybenzoate of 10wt%, Phenoxyethanol and
The sodium hydroxy methyl glycinate of 10wt%, stirs evenly, that is, completes emulsification procedure；
It is aged and filling：It is discharged in storage container, is placed in ageing no less than 48 hours between storage cream, through after the assay was approved,
It prepares, finally carries out filling according to the customary preparation methods of eye cream.
Assay method：
Pre-treatment：By test specimen absolute ethyl alcohol according to volume ratio be 1：1 ratio is diluted.
The sample liquid of 4.0mLDPPH solution and 1mL Jing Guo preceding processing is sequentially added in 10mL colorimetric cylinders, mixing is used immediately
1cm cuvettes survey light absorption value (A) at 517nm wavelength, and light absorption value is denoted as Ai, then surveys extinction after 30min is kept in dark place in greenhouse
Value, is denoted as Aj, ethanol solution of the check experiment only to add DPPH, and light absorption value is denoted as Ac.Free radical scavenging activity is calculated as follows
(K)：
K (%)=[1- (Ai-Aj)/Ac] X 100%
The result of the test of DPPH free radical scavenging abilities is shown in Fig. 1, as seen from Figure 1, its free radical of the product of experiment B groups
Scavenging activity is most strong, secondly the product for experiment A groups, and the oxidation resistance for testing the product of C groups is worst, and explanation will use patent
Number for 201210235667.0 the patent of invention Rosa Damascana and galam butter, Java Cananga Oil, jojoba oil and the dessert almond that prepare
For after product, the anti-aging ability of product to be stronger after oil compounding.
3 Tyrosinase inhibition assays of experimental example
Tyrosine generates polysaccharide through tyrosinase catalysis, and centre can finally generate black using a series of metabolic process
Pigment.Tyrosinase is the key substance of melanin generation.Therefore, the activity of tyrosinase in skin is reduced, it is possible to reduce black
Whitening, treatment chloasma, freckle are played the role of in the synthesis of pigment.
Test A groups:The product prepared according to embodiment 1.
Test B groups:The product prepared according to embodiment 2.
Test C groups：This group of test products are prepared in accordance with the following methods：Hyaluronic acid 0.3wt%, avenabeta glucosan
The methyl hydroxybenzoate 3.0wt% of 0.7wt%, 10wt%, the sodium hydroxy methyl glycinate of Phenoxyethanol 0.6wt%, 10wt%
0.8wt%, propylene glycol 4wt%, Acritamer 940 (water dilution) 30wt% of water 43wt%, 0.5wt%, Rosa Damascana
12.5wt%, PEG-40 5.1wt%.Wherein, the methyl hydroxybenzoate of 10wt% dilutes to obtain using propylene glycol, the hydroxyl first of 10wt%
The Acritamer 940 of base Sodium Glycinate and 0.5wt% dilute to obtain using deionized water.
Wherein, Rosa Damascana of the Rosa Damascana disclosed in using the patent of invention of Patent No. 201210235667.0.
It is prepared as follows：
The preparation of oil phase：Plants essential oil and PEG-40 are mixed, stirring is uniformly mixed it, for use；
The preparation of water phase：By water-soluble material hyaluronic acid, avenabeta glucosan, the Acritamer 940 addition of 0.5wt% is gone
In ionized water, 90~100 DEG C are heated with stirring to, keeps sterilizing for 20 minutes, is subsequently cooled to room temperature, for use；
Emulsification：After oil phase and Aqueous Phase Raw Material filtering, added in emulsification pot according to the sequence of water after first oil, carry out high-speed stirring
Mix, after oil, after Aqueous Phase Raw Material is sufficiently mixed into finely dispersed emulsion, then add the methyl hydroxybenzoate of 10wt%, Phenoxyethanol and
The sodium hydroxy methyl glycinate of 10wt%, stirs evenly, that is, completes emulsification procedure；
It is aged and filling：It is discharged in storage container, is placed in ageing no less than 48 hours between storage cream, through after the assay was approved,
It prepares, finally carries out filling according to the customary preparation methods of eye cream.Assay method：In 96 orifice plates, 1/15M phosphorus is added in every hole
The 60 μ L of tyrosine of 20 μ L, 5%DMSO sample solution of acid buffer (pH 6.8) 40 μ L, 0.29mg/mL, 300units/mL's
80 μ L of tyrosinase vibrate mixing, 30min are incubated at 37 DEG C, and inhale in being incubated front and rear measured at 490nm with microplate reader
Luminosity, using 40 μ L of 5%DMSO solution as blank solution, using kojic acid as positive control.Tyrosinase inhibition rate presses following public affairs
Formula calculates:
Tyrosinase inhibits percentage=[(A-B)-(C-D)]/(A-B) × 100%.
A is the absorption values of blank solution after being incubated；B is the absorption values of blank solution before being incubated；After C is is incubated
The absorption values of sample solution；D is the absorption values of sample solution before being incubated.
The results are shown in Figure 2, and as can be seen from Figure, experiment B set products are most strong to the rejection ability of tyrosinase, experiment
The product of C groups takes second place, and the product for testing A groups is worst, it is therefore intended that the present invention is by Rosa Damascana and galam butter, Java Cananga Oil, suddenly
For product, its tyrosinase rejection ability is stronger after bar oil and Sweet Almond Oil compounding suddenly.
4 human trial of embodiment
Test A groups:The product prepared according to embodiment 1.
Test B groups:The product prepared according to embodiment 2.
Test C groups：This group of test products are prepared in accordance with the following methods：Hyaluronic acid 0.3wt%, avenabeta glucosan
The methyl hydroxybenzoate 3.0wt% of 0.7wt%, 10wt%, the sodium hydroxy methyl glycinate of Phenoxyethanol 0.6wt%, 10wt%
0.8wt%, propylene glycol 4wt%, Acritamer 940 (water dilution) 30wt% of water 43wt%, 0.5wt%, Rosa Damascana
12.5wt%, PEG-40 5.1wt%.Wherein, the methyl hydroxybenzoate of 10wt% dilutes to obtain using propylene glycol, the hydroxyl first of 10wt%
The Acritamer 940 of base Sodium Glycinate and 0.5wt% dilute to obtain using deionized water.
Wherein, Rosa Damascana of the Rosa Damascana disclosed in using the patent of invention of Patent No. 201210235667.0.
It is prepared as follows：
The preparation of oil phase：Plants essential oil and PEG-40 are mixed, stirring is uniformly mixed it, for use；
The preparation of water phase：By water-soluble material hyaluronic acid, avenabeta glucosan, the Acritamer 940 addition of 0.5wt% is gone
In ionized water, 90~100 DEG C are heated with stirring to, keeps sterilizing for 20 minutes, is subsequently cooled to room temperature, for use；
Emulsification：After oil phase and Aqueous Phase Raw Material filtering, added in emulsification pot according to the sequence of water after first oil, carry out high-speed stirring
Mix, after oil, after Aqueous Phase Raw Material is sufficiently mixed into finely dispersed emulsion, then add the methyl hydroxybenzoate of 10wt%, Phenoxyethanol and
The sodium hydroxy methyl glycinate of 10wt%, stirs evenly, that is, completes emulsification procedure；
It is aged and filling：It is discharged in storage container, is placed in ageing no less than 48 hours between storage cream, through after the assay was approved,
It prepares, finally carries out filling according to the customary preparation methods of eye cream.
Crowd on probation：Subject 600 people of the age bracket at 20~55 years old.All subjects are without any skin and systematicness
Disease suffers from history, and recipient site skin is without exception.Wherein 200 people try out experiment A set products, and 200 people, which try out, tests B set products, and 200
People tries out experiment C set products.
(1) the instant test after product use, including product sensory test and the instant moisturizing measure of merit of product.
Product sensory is tested：The quality of product, color and luster, smell, use feeling are evaluated.
The sensory test result of product is shown in Table 2.
2 product sensory test result of table
For the using effect of further contrast experiment's set product, crowd is tried out respectively again to the quality of each set product, smearing
Fragrance afterwards, ductility, wettability (water moisture feeling), moist degree (glossy sense), heavy feeling, absorbability, glutinous soapy feeling, irritation, mistake
Quick property Comprehensive Assessment is simultaneously given a mark, and standards of grading are shown in Table 3, and sensory evaluation scores the results are shown in Table 4.
3. cosmetics sensory evaluation scores standard of table
4. sensory evaluation scores result of table
Instant moisturizing effect testing method：Subject needs unified mild detergent cleaning forearm to bend side before experiment,
In constant environment (indoor temperature be 22 DEG C~24 DEG C, humidity be 50%~60%) sit quietly 30min, then measured with moisture of skin
Instrument detects experiment position, is repeated 5 times respectively, obtains its average value；Then product is applied to experiment position, often locates test area
For 5 × 5cm2, test specimen 0.2g, before smearing, smear after at once, 5min, 10min, 15min, 30min, 45min,
60min is detected respectively again at these positions, records numerical value, and calculate sample average.
The instant replenishing water and preserving moisture effect detection result (X ± SD) of 5 product of table
The instant replenishing water and preserving moisture effect of product is shown in Table 5, and as can be seen from Table 5, after A set products, moisture of skin increases immediately
It is 82.3% to add rate, and increment rate is 13.6% after increment rate is 41.8%, 30 minutes after five minutes；After B set products, skin
The instant increment rate of moisture is 95.2%, and increment rate is 32.2% after increment rate is 66.8%, 30 minutes after five minutes；It is produced using C groups
After product, the instant increment rate of moisture of skin is 81.5%, and increment rate is 6.3% after increment rate is 28.1%, 30 minutes after five minutes,
Found out by data, the present invention is by Rosa Damascana and galam butter, Java Cananga Oil, jojoba oil and Sweet Almond Oil compounding for product
Afterwards, the instant moisturizing effect of product is the most notable.
(2) measure of merit after product is used for a long time
Test method：Subject uses the oil for testing skin before product and after 90 days respectively after morning and evening cleaning skin
Point, moisture, elasticity, collagenous fibres, eye circumference pigment and the anaphylaxis to product.Each data are repeated 5 times respectively, show that it is flat
Mean value, and calculate sample average.
Effect detection result (X ± SD) after the long-time service of 6 product of table
Effect after the long-acting use of product is shown in Table, and 6.As can be seen from Table 6, after trying out B set products, the skin of crowd is tried out
Oil, moisture, elasticity and eye circumference pigment improvement situation be superior to A, C set product, the skin oil of crowd on probation, moisture,
In the improvement situation of elasticity, A set products are slightly better than C set products；In the improvement of the collagen fibers of skin, eye circumference pigment of crowd on probation
In situation, C set products are better than A set products.In terms of the cutaneous sensibility to trying out crowd, B, C set product do not have allergic phenomena,
A set products have 87 people's allergy.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula carries out appropriate change and modification.Therefore, the invention is not limited in specific embodiment disclosed and described above, to this
Some modifications and changes of invention should also be as falling into the scope of the claims of the present invention.In addition, although this specification
In used some specific terms, but these terms are merely for convenience of description, do not limit the present invention in any way.
Claims (4)
1. a kind of preparation containing plants essential oil, which is characterized in that including as follows according to the component of mass percentage：Hyalomitome
Acid 0.2~0.5%, avenabeta glucosan 0.5~0.8%, the methyl hydroxybenzoate 2~3.5% of 10wt%, Phenoxyethanol 0.5~
0.8%th, the card wave of the sodium hydroxy methyl glycinate 0.5~1% of 10wt%, propylene glycol 3~5%, water 40~48.5%, 0.5wt%
Nurse 940 20~30%, plants essential oil 10~15% and PEG-40 4~5.5%；
Wherein, the plants essential oil contains as follows according to the component of mass percent meter：Rosa Damascana 0.1~0.5%, butter fruit
Oil 2~8%, Java Cananga Oil 3~5%, jojoba oil 1~3%, Sweet Almond Oil 2~8%, dihydrojasmonate 0.01~
0.03%th, indoles 0.01~0.02%, surplus are Glycerin, mixed triester with caprylic acid capric acid.
2. the preparation method of the preparation containing plants essential oil described in claim 1, which is characterized in that include the following steps：
(1) preparation of oil phase：Plants essential oil and PEG-40 are uniformly mixed, oil phase is obtained after filtering；
(2) preparation of water phase：The Acritamer 940 of hyaluronic acid, avenabeta glucosan, 0.5wt% are added in deionized water,
90~100 DEG C are heated with stirring to, sterilize 20min, is cooled to room temperature, water phase is obtained after filtering；
(3) it emulsifies：Oil phase obtained by step (1) is first added to emulsification pot, then water phase obtained by step (2) is added to emulsification pot,
High-speed stirred after oil phase is sufficiently mixed into finely dispersed emulsion with water phase, adds methyl hydroxybenzoate, the benzene oxygen of 10wt%
The sodium hydroxy methyl glycinate of ethyl alcohol and 10wt%, stirs evenly；
(4) step (3) products therefrom is aged at least 48h, obtains the preparation containing plants essential oil；
Wherein, the Acritamer 940 of the 0.5wt% dilutes to obtain with deionized water in advance, the methyl hydroxybenzoate thing of the 10wt%
It first dilutes to obtain with propylene glycol, the sodium hydroxy methyl glycinate of the 10wt% dilutes to obtain with deionized water in advance.
3. application of the preparation containing plants essential oil in eye-care described in claim 1.
4. a kind of eye-care product, which is characterized in that it includes it is as active component it is described in claim 1 contain plant essence
The preparation of oil.
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