CN107149578A - A kind of whitening cosmetic compound - Google Patents
A kind of whitening cosmetic compound Download PDFInfo
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- CN107149578A CN107149578A CN201710336171.5A CN201710336171A CN107149578A CN 107149578 A CN107149578 A CN 107149578A CN 201710336171 A CN201710336171 A CN 201710336171A CN 107149578 A CN107149578 A CN 107149578A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of whitening cosmetic compound, mainly include the compositions such as PCA zinc, chlorella/Lupinus albus protein fermentation product, bean cotyledon cauliflower/leaf/stem extraction, VCE, while with brightening skin whitening function, moisturizing, desalination wrinkle can also be moistened.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of whitening cosmetic compound.
Background technology
The type for the melanin that the colour of skin of people, hair color and eye color are mainly synthesized with melanocyte, quantity and distribution
It is relevant.Tyrosinase is the first step rate-limiting enzyme and key enzyme of B16 cell.Therefore, junket ammonia is all contained in most of whitening agents
Sour enzyme inhibitor.Chromatophore containing 4%-5% in the basal layer cell of human epidermal.The color of human skin is not depend on black
Chromatophore quantity, but depending on quantity, size, distribution and the melanocyte degree of melanosome.Therefore, some whitening compositions
By influenceing the formation of melanosome, ripe and transfer reaches the effect of whitening.《A kind of skin whitener and preparation method thereof》（Shen
Please number：CN104688654A）, disclose a kind of skin whitener using pearl powder as main composition, it is possible to increase the screen of skin
Hinder function, skin care increases the hydrauture of skin；《A kind of whitening body lotion》（Application number：CN201410500741.6）, it is public
Opened it is a kind of include Hydrolyzed Collagen, butter fruit resin extract, Margarita extract, Goat Milk extract, Angelica Dahurica extract,
The whitening body lotion of rose extract etc., it is adaptable to the after-sun of skin.But suppressing melanin generation, desalinate colour of skin side
Then it has been short of in face.
The content of the invention
, can be with brightening skin whitening, while moistening moisturizing, desalination wrinkle the invention provides a kind of whitening cosmetic compound
Line.
The present invention is achieved by the following technical solutions：
A kind of whitening cosmetic compound, includes the composition of following mass percent：PCA zinc 0.1-1%, chlorella/Lupinus albus
Protein fermentation product 0.1-5%, bean cotyledon cauliflower/leaf/stem extraction 0.1-5%, VCE 0.1-2%.
Further, the whitening cosmetic compound also includes Butyrospermum parkii fruit fat 0.5-1%, jojoba seed oil 0.5-
2%, sunflower seed oil 0.5-2%.
Further, the whitening cosmetic compound also includes NMF 6.52-22.2%, emollient 4.7-17.8%,
Emulsifying agent 1.8-4.3%, thickener 0.1-0.3%, preservative 0.1-0.3%.
It is preferred that, the NMF is made up of the composition of following mass percent：Glycerine 5-15%, butanediol 1-5% are transparent
Matter acid sodium 0.01-0.1%, polyglutamic acid sodium 0.01-0.1%, 1,2- hexylene glycol 0.5-2%.
It is preferred that, the emollient is made up of the composition of following mass percent：Dimethyl silicone polymer 1-3%, ring five gathers
Dimethyl siloxane 1-3%, C13-14 isoparaffin 0.1-0.3%, Dimethicone Crosspolymer 0.5-1%, spiny dogfish
Alkane 1-5%, carbonic acid dioctyl ester 1-5%, C10-18 resin acid triglyceride 0.1-0.5%.
It is preferred that, the emulsifying agent is made up of the composition of following mass percent：PEG-100 stearate 0.1-0.5%,
PEG-40 stearate 0.1-0.5%, stearine 1-2%, the 0.5-1% of ceteareth -20, laureth -
7 0.1-0.3%。
It is preferred that, the thickener is polyacrylamide, and the preservative is Phenoxyethanol.
Further, whitening cosmetic compound of the present invention also includes the composition of following mass percent：EDTA disodiums
0.01-0.1%, tocopherol 0.1-1%, Sensiva SC50 0.1-0.3%, cetostearyl alcohol 1-3%, acryloyldimethyl taurine
Ammonium/VP copolymer 0.1-0.5%, octyl group polymethyl siloxane 1-5%, deionized water surplus.
Further, the cosmetic composition is face cream or body lotion.
PCA zinc in the whitening cosmetic compound of the present invention can adjust sebum secretion amount, reduce the activity of esterified ferment,
Alleviate pore thick, Nasturtium officinale extract can releive physical fatigue, reduce edema, chlorella/Lupinus albus protein fermentation production
Thing can then increase the skin histology degree of packing, reduce the generation of wrinkle, improve skin condition, each composition synergy synergy can
Recover the naturally smooth of skin, reduce the generation of wrinkle.
VCE easily penetrates cuticula and enters skin corium simultaneously, into skin after decomposed by biology enzyme, reduce network
The activity of propylhomoserin enzyme, suppresses the generation of melanin, VC availability is improved, so as to play more preferable whitening skin lightening result；Suddenly
The same permeability with strength of bar seed oil, can wrap up the nutritional ingredients such as Butyrospermum parkii fruit fat, NMF and penetrate into skin nexine suddenly,
Further promote absorption of the bottom skin to nutriment, Butyrospermum parkii fruit fat can strengthen the action effect of NMF, i.e., it is each into
Divide Synergistic, skin is acted on from inside to outside, so as to play more preferable skin lightening moistening effect.
The invention has the advantages that：
First, firm skin, desalinates wrinkle：PCA zinc alleviation pore in whitening cosmetic compound of the present invention is thick, and Nasturtium officinale carries
Take thing can releive physical fatigue, reduce edema, chlorella/Lupinus albus protein fermentation product can then increase skin histology is tight
Solidity, three's collective effect improves skin condition, desalinates wrinkle, recovers skin smooth in the past.
2nd, melanin, brilliant white skin are desalinated：VCE easily penetrates cuticula and enters skin corium, into after skin
Decomposed by biology enzyme, substantially increase VC availability, suppress the generation of melanin while reducing TYR enzyme activity, it is bright
Bai Quanshen skin.
3rd, replenishing water and preserving moisture：The permeability of the strength of jojoba seed oil, can wrap up moisturizing ingredient penetrate into skin nexine, and
Synergistic in the presence of Butyrospermum parkii fruit fat, acts on skin from inside to outside, reaches more preferable moistening effect.
4th, it is widely used, natural no stimulation：Whitening cosmetic compound of the present invention can be used for the cosmetics of a variety of formulations
In, single formulation is not only restricted to, different skin care demands are suitable for, while raw material natural no stimulation, will not produce allergy etc. bad
Reaction.
Embodiment
In order that those skilled in the art will better understand the technical solution of the present invention, with reference to embodiment and to this
Invention product is described in further detail.
Embodiment 1
A kind of whitening cosmetic compound, its component proportion is as follows：PCA zinc 0.5%, chlorella/Lupinus albus protein fermentation product
3.6%, bean cotyledon cauliflower/leaf/stem extraction 3.2%, VCE 1.1%, glycerine 11%, butanediol 3%, Sodium Hyaluronate
0.08%, polyglutamic acid sodium 0.07%, 1,2- hexylene glycol 1.2%, saualane 3%, dimethyl silicone polymer 1.5%, the poly dimethyl of ring five
Siloxanes 2.2%, cetostearyl alcohol 2.1%, C13-14 isoparaffins 0.22%, Dimethicone Crosspolymer 0.8%,
C10-18 resin acids triglyceride 0.3%, PEG-100 stearates 0.3%, PEG-40 stearates 0.3%, glycerol stearate
Ester 1.6%, ceteareth -20 0.8%, laureth -7 0.2%, Butyrospermum parkii fruit fat 0.8%, jojoba seed oil
1.5%, sunflower seed oil 1.5%, EDTA disodiums 0.08%, tocopherol 0.8%, Sensiva SC50 0.22%, carbonic acid dioctyl ester 3%,
Ammonium acryloyldime-thyltaurate/VP copolymers 0.3%, octyl group polymethyl siloxane 3%, deionized water surplus；It is described to make up
Product composition is face cream or body lotion.
Embodiment 2
A kind of whitening cosmetic compound, its component proportion is as follows：PCA zinc 0.1%, chlorella/Lupinus albus protein fermentation product
5%, bean cotyledon cauliflower/leaf/stem extraction 0.1%, VCE 2%, glycerine 15%, butanediol 5%, Sodium Hyaluronate 0.1%,
Polyglutamic acid sodium 0.1%, 1,2- hexylene glycol 2%, saualane 5%, dimethyl silicone polymer 3%, ring five dimethyl silicone polymer 3%, whale
Wax stearyl alcohol 3%, C13-14 isoparaffins 0.3%, Dimethicone Crosspolymer 1%, C10-18 resin acid triglycerides
Class 0.5%, PEG-100 stearates 0.5%, PEG-40 stearates 0.5%, stearine 2%, cetostearyl alcohol gathers
Ether -20 1%, laureth -7 0.3%, Butyrospermum parkii fruit fat 1%, jojoba seed oil 2%, sunflower seed oil 2%, EDTA bis-
Sodium 0.1%, tocopherol 1%, Sensiva SC50 0.3%, carbonic acid dioctyl ester 5%, ammonium acryloyldime-thyltaurate/VP copolymers
0.5%, octyl group polymethyl siloxane 5%, deionized water surplus；The cosmetic composition is face cream or body lotion.
Embodiment 3
A kind of whitening cosmetic compound, its component proportion is as follows：PCA zinc 1%, chlorella/Lupinus albus protein fermentation product
0.1%, bean cotyledon cauliflower/leaf/stem extraction 5%, VCE 0.1%, glycerine 5%, butanediol 1%, Sodium Hyaluronate
0.01%, polyglutamic acid sodium 0.01%, 1,2- hexylene glycol 0.5%, saualane 1%, dimethyl silicone polymer 1%, the poly dimethyl silicon of ring five
Oxygen alkane 1%, cetostearyl alcohol 1%, C13-14 isoparaffins 0.1%, Dimethicone Crosspolymer 0.5%, C10-18
Resin acid triglyceride 0.1%, PEG-100 stearates 0.1%, PEG-40 stearates 0.1%, stearine 1%, whale
Wax stereth -20 0.5%, laureth -7 0.1%, Butyrospermum parkii fruit fat 0.5%, jojoba seed oil 0.5%, Xiang
Seed oil of sunflower 0.5%, EDTA disodiums 0.01%, tocopherol 0.1%, Sensiva SC50 0.1%, carbonic acid dioctyl ester 1%, acryloyl diformazan
Base taurine ammonium/VP copolymers 0.1%, octyl group polymethyl siloxane 1%, deionized water surplus；The cosmetic composition is
Face cream or body lotion.
Embodiment 4
A kind of whitening cosmetic compound, its component proportion is as follows：PCA zinc 0.8%, chlorella/Lupinus albus protein fermentation product
2.5%, bean cotyledon cauliflower/leaf/stem extraction 4%, VCE 0.8%, glycerine 7%, butanediol 2%, Sodium Hyaluronate
0.04%, polyglutamic acid sodium 0.03%, 1,2- hexylene glycol 0.9%, saualane 2%, dimethyl silicone polymer 1.5%, the poly dimethyl of ring five
Siloxanes 1.2%, cetostearyl alcohol 1.2%, C13-14 isoparaffins 0.15%, Dimethicone Crosspolymer 0.7%,
C10-18 resin acids triglyceride 0.2%, PEG-100 stearates 0.3%, PEG-40 stearates 0.2%, glycerol stearate
Ester 1.2%, ceteareth -20 0.7%, laureth -7 0.18%, Butyrospermum parkii fruit fat 0.62%, Jojoba seed
Oil 1.1%, sunflower seed oil 0.8%, EDTA disodiums 0.05%, tocopherol 0.3%, Sensiva SC50 0.16%, carbonic acid dioctyl ester
2%, ammonium acryloyldime-thyltaurate/VP copolymers 0.2%, octyl group polymethyl siloxane 2%, deionized water surplus；Describedization
Cosmetic compositions are face cream or body lotion.
Comparative example 1
Difference with embodiment 1 is not add chlorella/Lupinus albus protein fermentation product, other preparation conditions and method and reality
Apply example 1 identical.
Comparative example 2
Difference with embodiment 1 is not add VCE, and other preparation conditions and method are same as Example 1.
Comparative example 3
Difference with embodiment 1 is not add bean cotyledon cauliflower/leaf/stem extraction, other preparation conditions and method and the phase of embodiment 1
Together.
Comparative example 4
Difference with embodiment 1 is not add PCA zinc, and other preparation conditions and method are same as Example 1.
In order to assess the skin whitening, moisturizing and desalination wrinkle performance of products obtained therefrom of the present invention, respectively to embodiment 1-4, comparative example
Product obtained by 1-4 carries out using test with volunteer, and specific test result is as shown in table 1：
Table 1
As can be seen here, cosmetics produced by the present invention are used for a long time, can skin whitening, moisturizing, while the skin desalination wrinkle that can compact.
Suppress melanin, desalinate colour of skin efficacy validation
Detection results on probation are carried out to product prepared by embodiment 1-4 and comparative example 1-4, while commercially available declaring brilliant white with a
Face cream be control group.
Test object：Male 6 female 24 of each experimental group（25-50 Sui）Equal skin is dim；Test zone：Face and arm；
Tester：Dermal melanin and ferroheme tester（Mexameter MX18）.Use：Morning and evening 1 time daily, persistently using 8
Week；Test event：Light spot.
Method：Environment after subject's test same day face cleaning, shower in 23 ~ 25 DEG C of room temperature, relative humidity 50%-60% is sat quietly
After 30min, look steadily it and loosen body muscle group, gently close eyes.With dermal melanin and ferroheme tester（Mexameter
MX18）Detect its face and arm dermal melanin precipitation status, during measurement probe in same tested region duplicate measurements 3 times,
Average.Test environment relative temperature is kept during measurement, it is to avoid light, the influence of sound interference, being exerted oneself during using probe will
Uniformly, the pressure of application should be constant.Subject uses the melanin feelings for measuring tested region after 2 weeks, 4 weeks, 6 weeks, 8 weeks again
Condition.Terminate measurement, preserve data, finishing analysis data：
Table 2：Subject is compared in tested region using primary data analysis before product
As seen from Table 2, before using product, each position pigment degree is different.
The tested region of subject is used before and after product, and pigment level data com-parison and analysis is shown in Table 3（x For mean,SD For mark
It is accurate poor,N For sample number）：
Table 3
The skin melanin numerical value change of recipient site is with the product time is used in the visible embodiment 1-4 of table 3, gradually in reduction
Trend, thus illustrates that cosmetic composition of the present invention has whitening effect；Comparative example 1-3 recipient site skin melanin numerical value has
Reduced, reduced slower；In comparative example 4, skin melanin numerical value is with the extension of time, numerical value slightly has growth.By implementing
Example 1-4 and comparative example 1-4 contrasts can be obtained, and whitening cosmetic compound of the present invention can effectively reduce the deposition of dermal melanin, long
Phase is using can reach good brilliant white skin effects.
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.
Claims (9)
1. a kind of whitening cosmetic compound, it is characterised in that the whitening cosmetic compound includes following mass percent
Composition：PCA zinc 0.1-1%, chlorella/Lupinus albus protein fermentation product 0.1-5%, bean cotyledon cauliflower/leaf/stem extraction 0.1-
5%, VCE 0.1-2%.
2. whitening cosmetic compound according to claim 1, it is characterised in that the whitening cosmetic compound is also wrapped
Include Butyrospermum parkii fruit fat 0.5-1%, jojoba seed oil 0.5-2%, sunflower seed oil 0.5-2%.
3. whitening cosmetic compound according to claim 1, it is characterised in that the whitening cosmetic compound is also wrapped
Include NMF 6.52-22.2%, emollient 4.7-17.8%, emulsifying agent 1.8-4.3%, thickener 0.1-0.3%, preservative 0.1-
0.3%。
4. whitening cosmetic compound according to claim 3, it is characterised in that the NMF is by following quality percentage
The composition composition of ratio：Glycerine 5-15%, butanediol 1-5%, Sodium Hyaluronate 0.01-0.1%, polyglutamic acid sodium 0.01-0.1%, 1,
2- hexylene glycols 0.5-2%.
5. whitening cosmetic compound according to claim 3, it is characterised in that the emollient is by following quality percentage
The composition composition of ratio：Dimethyl silicone polymer 1-3%, ring five dimethyl silicone polymer 1-3%, C13-14 isoparaffin 0.1-
0.3%, Dimethicone Crosspolymer 0.5-1%, saualane 1-5%, carbonic acid dioctyl ester 1-5%, C10-18 resin acid glycerine
Three esters 0.1-0.5%.
6. whitening cosmetic compound according to claim 3, it is characterised in that the emulsifying agent is by following quality percentage
The composition composition of ratio：PEG-100 stearates 0.1-0.5%, PEG-40 stearate 0.1-0.5%, stearine 1-
2%, the 0.5-1% of ceteareth -20, the 0.1-0.3% of laureth -7.
7. whitening cosmetic compound according to claim 3, it is characterised in that the thickener is polyacrylamide,
The preservative is Phenoxyethanol.
8. the whitening cosmetic compound according to claim any one of 1-7, it is characterised in that the skin-lightening cosmetic group
Compound also includes the composition of following mass percent：EDTA disodium 0.01-0.1%, tocopherol 0.1-1%, Sensiva SC50
0.1-0.3%, cetostearyl alcohol 1-3%, ammonium acryloyldime-thyltaurate/VP copolymer 0.1-0.5%, octyl group methyl polysilicone
Alkane 1-5%, deionized water surplus.
9. the whitening cosmetic compound according to claim any one of 1-8, it is characterised in that the cosmetic composition
For face cream or body lotion.
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|---|---|---|---|---|
| CN107951774A (en) * | 2017-12-19 | 2018-04-24 | 武汉北度生物科技有限公司 | A kind of antioxidation cosmetic water of the extract component containing apple skin and preparation method thereof |
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| CN108078854B (en) * | 2018-01-10 | 2019-01-08 | 壹田（广州）生活健康用品有限公司 | Hand frost and preparation method thereof is repaired in a kind of moisturizing |
| CN109908069A (en) * | 2019-04-24 | 2019-06-21 | 福州东艺善秀商业有限公司 | A kind of milky lotion of multifunctional plant extractive and preparation method thereof |
| CN111700836A (en) * | 2020-07-24 | 2020-09-25 | 嘉文丽（福建）化妆品有限公司 | Composition capable of improving skin color and whitening skin and skin care product containing composition |
| CN112778085A (en) * | 2021-01-20 | 2021-05-11 | 上海博璞诺科技发展有限公司 | 1, 2-hexanediol and purification method and application thereof |
| CN112675098A (en) * | 2021-02-02 | 2021-04-20 | 广东梵蜜琳生物科技有限公司 | Smoothing toner containing composition for regulating time rhythm and preparation method thereof |
| CN112933006A (en) * | 2021-02-02 | 2021-06-11 | 广东梵蜜琳生物科技有限公司 | Facial cleanser containing composition for regulating time rhythm and preparation method thereof |
| CN113332212A (en) * | 2021-06-28 | 2021-09-03 | 深圳华信健康产业有限公司 | Whitening composition and preparation method and application thereof |
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