CN107789285A - A kind of anti-oxidant and lightening compositions and the skin care item containing said composition - Google Patents
A kind of anti-oxidant and lightening compositions and the skin care item containing said composition Download PDFInfo
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- CN107789285A CN107789285A CN201711245935.6A CN201711245935A CN107789285A CN 107789285 A CN107789285 A CN 107789285A CN 201711245935 A CN201711245935 A CN 201711245935A CN 107789285 A CN107789285 A CN 107789285A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
Skin care item the present invention relates to a kind of anti-oxidant and lightening compositions and containing said composition, belong to cosmetic technical field.Anti-oxidant and lightening compositions of the invention include following components in parts by weight:30~50 parts of bermuda lily extract, 15~30 parts of perfume Flos Nelumbinis extract, 20~40 parts of rye seed extract.For the composition of the present invention due to bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract being organically combined, it has excellent anti-oxidant and whitening effect.
Description
Technical field
Skin care item the present invention relates to a kind of anti-oxidant and lightening compositions and containing said composition, belong to cosmetic art
Field.
Background technology
Cosmetics in the market are a lot, a feast for the eyes, these cosmetics be mainly used for improve skin health and/
Or physical appearance, such as:It can delay, in addition elimination excess skin pigmentation (senile plaque expelling, freckle, rash spot, darken, it is uneven
Equal tone etc.), the cosmetics of wrinkle and other typical cases chronic change relevant to human dermatological lesions with skin aging or environment.
In order to maintain or skin is got well, young state is kept, conventional skin care method is using NMF
Nursing, can also use skin lightening agent, the gel of transparent or semitransparent form.Distillate medicinal water and emulsion compositions also have to consumer to be inhaled
Gravitation, because the administration of above-mentioned composition will make skin look bright and young.
Mainly have with Types Below for net white skin lightening cosmetics:(1) organic acid:Include malic acid, citric acid, azelaic acid
It is to accelerate coming off for skin aging cell Deng, their major function, so that skin looks tenderer white, shortcoming is organic
Acid the easy acid etching skin of misoperation and will cause under acid conditions of the PH less than 4 using just playing a role, in practical application
It is allergic;(2) black bearberry former times class:Inhibitory action can be known as to black, still in the black bearberry former times (arbutin) generally used always
This composition can resolve into virose quinhydrones (hydroquinone), have cytotoxicity, U.S. be present during Clinical practice
The phenomenon to rebound in vain;(3) Vitamin C class:Such cosmetics has blanching effect, can effectively decompose melanin, but its belonging to
Unstability material is learned, keeps its activity more difficult;(4) natural plant extraction species:Such cosmetics majority contains whitening side
The flavonoids plant extracts in face, it is a kind of natural anti-oxidant composition, one is occupied in terms of security, stability and validity
Fixed advantage, weak point are that onset time is longer.
The content of the invention
It is an object of the invention to overcome in place of above-mentioned the deficiencies in the prior art and providing one kind has anti-oxidant and whitening
The composition of function and the skin care item containing said composition.
To achieve the above object, the technical scheme taken of the present invention is:A kind of anti-oxidant and lightening compositions, under it includes
State 15~30 parts of 30~50 parts of component bermuda lily extract, the perfume Flos Nelumbinis extract of parts by weight, rye seed extract 20~
40 parts.
Bermuda lily, it is Liliales, Liliaceae, lilium herbaceos perennial.Active material contained by all sorts of flowers lily point
Cloth has polysaccharide, steroid saponin, phenolic compound, flavonoid in the parts such as flower, leaf, bulb, the active component being currently known
Thing and alkaloid etc..Bermuda lily it is widely used, it is available for viewing and admiring or makees food and spices containing aromatic oil, and its bulb is starch-containing
Can edible and extraction starch.Bermuda lily extract of the present invention can be adopted using the flower, leaf or bulb of bermuda lily as raw material
It is prepared with existing method.
The perfume Flos Nelumbinis extract of the present invention is made up of perfume lotus flower total starches and perfume lotus flower general flavone.Perfume lotus flower is total
Polysaccharide origin is natural plant polyose glue in the ovary of perfume lotus flower flower, tests prove that being protected with very strong moisturizing
Wet effect, it can effectively alleviate skin of face and dry peeling, furfur, pruitus etc., active protection skin of face, the isolation external world
Stimulation, inflammation and environmental pollution etc. caused by skin aging etc., be that skin can keep more lasting water to moisten state, reach guarantor
The effect of wet and deep water supplement.And perfume lotus flower general flavone is then derived from pistil and the part ovary of perfume lotus flower, through experiment
Prove, it has the suppression tyrosinase activity more stronger than traditional skin whitening, moisturizing compound ursin, is a kind of very effective junket
Propylhomoserin enzyme inhibitor.Tyrosinase is the rate-limiting enzyme of B16 cell, not only determines the speed of B16 cell, or melanocyte
The ripe characteristic mark of cell differentiation.In human body, the melanin that tyrosinase is then primarily present in skin epidermal cells is thin
In born of the same parents, the activity of tyrosinase is related to melanin genesis amount, controls the i.e. controllable melanogenesis amount of its vigor.Therefore, tyrosine
Enzyme inhibitor is added in cosmetics as with the additive that skin whitening, moisturizing acts on.
Rye seed is rich in araboxylan, forulic acid and other Polyphenols, as skin care raw material in use, not only having
The effect of free radical is reduced, more can crucially promote the β 1 of beta 2 integrin alpha 2, talin synthesis, increase collagen content;Together
When accelerate α-SMA generation, and then increase fibroblastic convergent force, continuing use can releive expression line, be that skin is seen
Get up fuller compact.
It has been found that the composition of the present invention is due to by bermuda lily extract, perfume Flos Nelumbinis extract and rye seed
Extract is organically combined, and it has excellent anti-oxidant and whitening effect.
The composition of the present invention can be by pressing institute by bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract
Parts by weight are stated to be mixed to get.
As of the present invention anti-oxidant and lightening compositions preferred embodiments, the composition includes following weight
The component of part:35~45 parts of bermuda lily extract, 25~30 parts of perfume Flos Nelumbinis extract, 30~40 parts of rye seed extract.
In the present composition, the proportioning of component can influence the effect of composition, and research is found, in the preferable parts by weight scope
Interior, the antioxidant effect of the present composition is more preferably.
As of the present invention anti-oxidant and lightening compositions preferred forms, the composition includes following weight
The component of part:40 parts of bermuda lily extract, 30 parts of perfume Flos Nelumbinis extract, 30 parts of rye seed extract.Applicant is a large amount of
Had been surprisingly found that in experiment, under the specific weight proportion, the antioxidant effect of the present composition reaches optimal.
As of the present invention anti-oxidant and lightening compositions preferred embodiments, the perfume Flos Nelumbinis extract with it is black
The weight ratio of wheat seed extract is 1:2.The weight ratio of perfume Flos Nelumbinis extract and rye seed extract is 1:When 2, of the present invention group
The whitening effect of compound is more preferable.
In addition, the application present invention also offers above-mentioned anti-oxidant and lightening compositions in skin care item are prepared.
Finally, above-mentioned anti-oxidant and lightening compositions skin care item are contained present invention also offers a kind of.The skin care item
Can be face cream, eye cream, facial mask, mildy wash, smoothing toner or essence etc..
As the preferred embodiment of skin care item of the present invention, weight percent of the composition in the skin care item
Than for 1.0~6.0%.
As the more preferably embodiment of skin care item of the present invention, weight hundred of the composition in the skin care item
Divide than being 5.0%.
As the preferred embodiment of skin care item of the present invention, the skin care item also include following weight percent
Component:NMF 15~25%, surfactant 18~24%, preservative 0.4~0.7%, thickener 1.5~3%, surplus are
Water.NMF can make the percutaneous permeability that skin keeps wettability effect without influenceing composition, and thickener can make skin smooth
Sense and wetness sensation are sticky without having.
As the more preferably embodiment of skin care item of the present invention, the NMF is propane diols, the surface-active
Agent is laureth sodium sulfovinate or laureth sulfuric ester ammonium, and the thickener is xanthans or carragheen, described anti-
Rotten agent is propylparaben or methyl p-hydroxybenzoate.
The skin care item of the present invention as a rule can making or emulsification method that by this area, oneself knows be made, these methods
In general it is included in one or more steps and sequentially mixes dispensing to relatively uniform state, while carries out or not
Heated, cooled down, high shear mixing etc..
Compared with prior art, beneficial effects of the present invention are:The present invention extracts bermuda lily extract, perfume lotus flower
Thing and rye seed extract are organically combined, and obtained composition and skin care item are respectively provided with excellent anti-oxidant and whitening effect
Fruit.
Embodiment
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention
It is described further.
In following embodiments, bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract use existing side
Method be prepared or commercially gained.
Embodiment 1
A kind of anti-oxidant and lightening compositions the embodiment of the present invention, the anti-oxidant and lightening compositions of the present embodiment are under
State the component composition of parts by weight:40 parts of bermuda lily extract, 30 parts of perfume Flos Nelumbinis extract, 30 parts of rye seed extract.
The composition of the present embodiment can be by the way that bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract be pressed
The parts by weight are mixed to get.
The skin care item of the present embodiment are made up of the component of following weight percentage:The composition 5.0% of the present embodiment, moisturizing
Agent 15%, surfactant 24%, preservative 0.6%, thickener 2.2%, surplus are water;Wherein described NMF is the third two
Alcohol, the surfactant are laureth sodium sulfovinate, and the thickener is xanthans, and the preservative is para hydroxybenzene
Propyl formate.
The preparation method of the present embodiment skin care item is:
(1) NMF and thickener are added in emulsification pot, adds deionized water, be first stirred at room temperature and thoroughly divide
Dissipate, then warming while stirring is to 75~80 DEG C, continues stirring to being uniformly dissolved, keeping temperature;
(2) by after surfactant and preservative heating, it is added in the emulsification pot of step (1), and temperature control is existed
Between 75-80 DEG C, emulsifying, then logical cooling water temperature are then carried out, when cooling to 50 DEG C, adds the combination of the present embodiment
Thing, continue to be stirred until homogeneous, obtain the skin care item of the present embodiment.
Embodiment 2
A kind of anti-oxidant and lightening compositions the embodiment of the present invention, the anti-oxidant and lightening compositions of the present embodiment are under
State the component composition of parts by weight:35 parts of bermuda lily extract, 28 parts of perfume Flos Nelumbinis extract, 40 parts of rye seed extract.
The composition of the present embodiment can be by the way that bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract be pressed
The parts by weight are mixed to get.
The skin care item of the present embodiment are made up of the component of following weight percentage:The composition 1.0% of the present embodiment, moisturizing
Agent 25%, surfactant 18%, preservative 0.4%, thickener 3%, surplus are water;Wherein described NMF is propane diols,
The surfactant is laureth sulfuric ester ammonium, and the thickener is xanthans, and the preservative is para hydroxybenzene first
Sour methyl esters.
The preparation method of the present embodiment skin care item is the same as embodiment 1.
Embodiment 3
A kind of anti-oxidant and lightening compositions the embodiment of the present invention, the anti-oxidant and lightening compositions of the present embodiment are under
State the component composition of parts by weight:45 parts of bermuda lily extract, 25 parts of perfume Flos Nelumbinis extract, 35 parts of rye seed extract.
The composition of the present embodiment can be by the way that bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract be pressed
The parts by weight are mixed to get.
The skin care item of the present embodiment are made up of the component of following weight percentage:The composition 6.0% of the present embodiment, moisturizing
Agent 20%, surfactant 21%, preservative 0.7%, thickener 1.5%, surplus are water;Wherein described NMF is the third two
Alcohol, the surfactant are laureth sulfuric ester ammonium, and the thickener is carragheen, and the preservative is para hydroxybenzene
Methyl formate.
The preparation method of the present embodiment skin care item is the same as embodiment 1.
Embodiment 4
A kind of anti-oxidant and lightening compositions the embodiment of the present invention, the anti-oxidant and lightening compositions of the present embodiment are under
State 30 parts of component composition bermuda lily extract, 20 parts of perfume Flos Nelumbinis extract, 40 parts of the rye seed extract of parts by weight.
The composition of the present embodiment can be by the way that bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract be pressed
The parts by weight are mixed to get.
The skin care item of the present embodiment are made up of the component of following weight percentage:The composition 5.0% of the present embodiment, moisturizing
Agent 15%, surfactant 24%, preservative 0.6%, thickener 2.2%, surplus are water;Wherein described NMF is the third two
Alcohol, the surfactant are laureth sodium sulfovinate, and the thickener is xanthans, and the preservative is para hydroxybenzene
Propyl formate.
The preparation method of the present embodiment skin care item is the same as embodiment 1.
Embodiment 5
A kind of anti-oxidant and lightening compositions the embodiment of the present invention, the anti-oxidant and lightening compositions of the present embodiment are under
State the component composition of parts by weight:50 parts of bermuda lily extract, 15 parts of perfume Flos Nelumbinis extract, 20 parts of rye seed extract.
The composition of the present embodiment can be by the way that bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract be pressed
The parts by weight are mixed to get.
The skin care item of the present embodiment are made up of the component of following weight percentage:The composition 5.0% of the present embodiment, moisturizing
Agent 15%, surfactant 24%, preservative 0.6%, thickener 2.2%, surplus are water;Wherein described NMF is the third two
Alcohol, the surfactant are laureth sulfuric ester ammonium, and the thickener is carragheen, and the preservative is para hydroxybenzene
Propyl formate.
The preparation method of the present embodiment skin care item is the same as embodiment 1.
Effect example 1
In order to investigate in skin care item of the present invention, in anti-oxidant and lightening compositions each group distribution ratio it is anti-oxidant to skin care item and
The influence of whitening effect, we are prepared for different test group skin care item according to the method for embodiment 1.Each test group skin care item are equal
It is made up of the component of following weight percentage:Anti-oxidant and lightening compositions 1.0~6.0%, NMF 15~25%, surface are lived
Property agent 18~24%, preservative 0.4~0.7%, thickener 1.5~3%, surplus is water;Wherein anti-oxidant and lightening compositions
Component composition as shown in Table 1.
Table 1
The antioxidation activity of above-mentioned test group skin care item is represented with scavenging ability of DPPH free radical size.Take test group 1~9
Each 2.0g of sample, add 2.0mL1.52 × 10~4Mmol/L DPPH ethanol solutions are fully mixed, and room temperature lucifuge is stood
After 30min, using solvent as blank control, absorbance A 1 is surveyed at 517nm;Be made it with same volume solvent instead of sample solution negative right
According to measure absorbance A 2;Blank group is done instead of DPPH solution with same volume absolute ethyl alcohol, determines absorbance A 3.Every group is done 3 weights
It is multiple, it is averaged.Clearance rate is calculated as follows:
Sample is to DPPH clearance rate (%)=[1- (A1-A3)/A2] × 100%, as a result as shown in table 2.
Table 2
Test group | DPPH clearance rate, % |
Test group 1 | 88.7 |
Test group 2 | 87.2 |
Test group 3 | 86.8 |
Test group 4 | 84.9 |
Test group 5 | 85.3 |
Test group 6 | 62.1 |
Test group 7 | 61.8 |
Test group 8 | 64.2 |
Test group 9 | 64.5 |
In above-mentioned table 2, in test group 1~5 bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extract this four
The parts by weight of kind material are in scope of the present invention, and bermuda lily extract, the extraction of perfume lotus flower in test group 6~9
The parts by weight of these four materials of thing and rye seed extract are not entirely in scope of the present invention.1~5 skin care item of test group
Antioxidant effect be substantially better than test group 6~9, it is seen then that bermuda lily extract, perfume Flos Nelumbinis extract and rye seed extraction
These four materials of thing together, make the antioxidant effect of skin care item of the present invention more preferable by parts by weight of composition of the present invention.Also,
From the result of table 2, the antioxidant effect of skin care item is optimal described in test group 1, it follows that bermuda lily extract is 40
When part, perfume Flos Nelumbinis extract are 30 parts, rye seed extract is 30 parts, the antioxidant effect of skin care item of the present invention is best, this
It is that applicant has been surprisingly found that.
Effect example 2
The skin care item of the present invention not only have oxidation resistant effect, moreover it is possible to skin whitening.This effect example has investigated perfume lotus
The weight of flower extract and rye seed extract compares the influence of skin care item whitening effect of the present invention.In order to investigate the influence, I
Different test group skin care item are prepared for according to the method for embodiment 1.Each test group skin care item are by following weight percentage
Component composition:Anti-oxidant and lightening compositions 1.0~6.0%, NMF 15~25%, surfactant 18~24%, prevent
Rotten agent 0.4~0.7%, thickener 1.5~3%, surplus are water;Anti-oxidant and lightening compositions are by following components in parts by weight group
Into:30~50 parts of bermuda lily extract, 15~30 parts of perfume Flos Nelumbinis extract, 20~40 parts of rye seed extract;Wherein, it is fragrant
The weight ratio of water Flos Nelumbinis extract and rye seed extract is as shown in table 3.
Table 3
In order to investigate the whitening effect of above-mentioned test group skin care item, we use it for female volunteers, measure human body skin
Black rope content in skin, to evaluate the white-skinned face function of skin care item.
Experiment is using MEXAMETER MX18 skin pigments instrument using 1 day before cosmetics and continuous use cosmetics 20 days
The melanin content of its hand skin is determined afterwards.Determination of the environment:(22 ± 1 DEG C, humidity (50 ± 5) %, make even test environment temperature
Average.Study subject uses a skin care item daily, and application method is:After cleaning hand skin, dry, applied cosmetics with hand
It is put on hand skin.Study subject is during test without using other whitening products.Measured value is higher, illustrates black in skin
Pigment content is higher.
Melanin reduced rate=(use the melanin content one of 1 day before cosmetics that cosmetics black after 20 days is used continuously
Cellulose content)/use melanin content × 100% of 1 day before cosmetics.
Melanin reduced rate is higher, illustrates that whitening effect is more obvious.Experimental result is as shown in table 4.
Table 4
Melanin reduced rate, % | |
Test group 1 | 17.8 |
Test group 2 | 20.6 |
Test group 3 | 18.1 |
Test group 4 | 16.9 |
From table 4, the skin care item melanin reduced rate highest of test group 2, it is seen then that perfume Flos Nelumbinis extract and rye seed
The weight ratio of extract is 1:When 2, the effect of skin care item whitening of the present invention reaches optimal.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
- A kind of 1. anti-oxidant and lightening compositions, it is characterised in that:Including following components in parts by weight bermuda lily extract 30 ~50 parts, 15~30 parts of perfume Flos Nelumbinis extract, 20~40 parts of rye seed extract.
- 2. anti-oxidant and lightening compositions as claimed in claim 1, it is characterised in that:Including following components in parts by weight:In vain 35~45 parts of Bulbus Lilii extract of flower, 25~30 parts of perfume Flos Nelumbinis extract, 30~40 parts of rye seed extract.
- 3. anti-oxidant and lightening compositions as claimed in claim 2, it is characterised in that:Including following components in parts by weight:In vain 40 parts of Bulbus Lilii extract of flower, 30 parts of perfume Flos Nelumbinis extract, 30 parts of rye seed extract.
- 4. anti-oxidant and lightening compositions as claimed in claim 1, it is characterised in that:The perfume Flos Nelumbinis extract and rye The weight ratio of seed extract is 1:2.
- 5. application of anti-oxidant as described in any one of the Claims 1 to 4 and lightening compositions in skin care item are prepared.
- 6. a kind of contain anti-oxidant and lightening compositions the skin care item as described in any one of Claims 1 to 4.
- 7. skin care item as claimed in claim 6, it is characterised in that:Percentage by weight of the composition in the skin care item For 1.0~6.0%.
- 8. skin care item as claimed in claim 7, it is characterised in that:Percentage by weight of the composition in the skin care item For 5.0%.
- 9. skin care item as claimed in claim 8, it is characterised in that:Also include the component of following weight percent:NMF 15~25%, surfactant 18~24%, preservative 0.4~0.7%, thickener 1.5~3%, surplus is water.
- 10. skin care item as claimed in claim 9, it is characterised in that:The NMF is propane diols, and the surfactant is Laureth sodium sulfovinate or laureth sulfuric ester ammonium, the thickener are xanthans or carragheen, the preservative For propylparaben or methyl p-hydroxybenzoate.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109303734A (en) * | 2018-12-13 | 2019-02-05 | 北京天奇益人健康科技有限公司 | A kind of perfume Flos Nelumbinis extract and its preparing the application in cosmetics |
CN110237003A (en) * | 2019-07-10 | 2019-09-17 | 西双版纳宝翠香莲生物科技有限公司 | A kind of perfume Flos Nelumbinis extract and its application in skin care item |
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CN103622852A (en) * | 2012-05-29 | 2014-03-12 | 玫琳凯有限公司 | Cosmetic composition |
CN106798718A (en) * | 2017-03-28 | 2017-06-06 | 佛山汇沐化学科技有限公司 | A kind of moisture surge treatment formula |
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2017
- 2017-11-30 CN CN201711245935.6A patent/CN107789285A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103622852A (en) * | 2012-05-29 | 2014-03-12 | 玫琳凯有限公司 | Cosmetic composition |
CN106798718A (en) * | 2017-03-28 | 2017-06-06 | 佛山汇沐化学科技有限公司 | A kind of moisture surge treatment formula |
Non-Patent Citations (1)
Title |
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王建新: "《化妆品植物原料大全》", 30 June 2012 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109303734A (en) * | 2018-12-13 | 2019-02-05 | 北京天奇益人健康科技有限公司 | A kind of perfume Flos Nelumbinis extract and its preparing the application in cosmetics |
CN110237003A (en) * | 2019-07-10 | 2019-09-17 | 西双版纳宝翠香莲生物科技有限公司 | A kind of perfume Flos Nelumbinis extract and its application in skin care item |
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