CN103462845A - Composite whitening and banishing essence and preparation method thereof - Google Patents
Composite whitening and banishing essence and preparation method thereof Download PDFInfo
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Abstract
The invention specifically discloses composite whitening and banishing essence and a preparation method thereof. The composite whitening and banishing essence comprises the following raw materials in percent by weight: 1 to 25 percent of Chinese herb active site extract, 0.1 to 10 percent of ethylhexyl ferulate, 0.1 to 5 percent of vitamin C ethyl ether, 0.05 to 3 percent of nicotinamide, 10 to 40 percent of grease, 1 to 6 percent of emulsifier, 1 to 15 percent of moisturizing agent, 0.1 to 1.5 percent of preservative, 0.1 to 0.5 percent of essence and the balance of deionized water. By virtue of the composite whitening and banishing essence, the activity of tyrosinase can be effectively inhibited, oxygen free radicals are efficiently eliminated, forming of melanin is prevented, and the formed melanin is decomposed and faded; meanwhile, an endocrine system of a human body can be regulated, and injuries to the skin caused by chemical components such as hormone are repaired, so that effects of treating both symptoms and root causes comprehensively and quickly are achieved.
Description
Technical field
The present invention relates to the composite whitening spot-dispelling frost, be specifically related to composite whitening spot-dispelling frost and preparation method thereof.
Background technology
Everybody has a love of beauty, but a lot of women is worried for freckle, chloasma on the face.Freckle, chloasma are a kind of common skin phenomenons that a large amount of melanin is inhomogeneous in the human body deposition distribution and be difficult to healing, have had a strong impact on patient's mental health.
China's Traditional Chinese Medicine is with in short having summarized the reason of long speckle on the face: " spottiness on the face, the interior silt piece of body, have speckle that silt must be arranged, and controls silt not from blood." will be corresponding at face without the qi depression to blood stasis at position in body position display, also just formed speckle.When human endocrine is disorderly, caused the QI-blood circulation in human body not smooth, passages through which vital energy circulates is obstructed, cause in congestion and stop, the stagnation of QI is not smooth, and painstaking effort can not reach skin face, nutrition skin, and the melanin in skin just can not discharge along with the eubolism of human body, so long-term, just formed mottle.Equally, the cosmetics that contain lead, hydrargyrum, hormones chemical substance because of Exposure to Sunlight and life-time service can destroy epidermis open weave structure, increase the weight of the formation of deposits of mottle.In body, without qi depression to blood stasis and the pathological changes at position, will relatively partly with speckle, show at face.So solve the main method of the problem of mottle, be: will be careful in one's diet on the one hand, avoid eating too many junk food, eat the formation that light food can be alleviated mottle more; The 2nd, form good rule of life and living habit, not Smoking And Drinking; The 3rd, use safe whitening and speckle dispelling product, dispel melanin in skin and the mottle of epidermis.
The product of whitening and speckle dispelling is a lot of in the market, and its contained whitening and speckle dispelling composition mainly contains: arbutin, hydroquinone, vitamin C, kojic acid, Azelaic Acid, cell growth factor etc.There is following problem in these products: (1) can only be effective to some mottle, as arbutin can only be effective to chloasma, invalid to freckle.(2) skin is existed and stimulates and infringement, as the cosmetics containing hydroquinone more easily cause systemic toxicity, easily cause contact dermatitis as kojic acid when addition is larger.(3) unstable, easily variable color, absorb as vitamin C is unfavorable for skin, and the very easily oxidation stain and lose whitening effect of heat, light time; The active shelf-life of cell growth factor is shorter, is difficult for long preservation.
Summary of the invention
In order to solve the problem existed in existing whitening and speckle dispelling product, the object of the invention is to provide comprehensive, safe composite whitening spot-dispelling frost of a kind of curative effect and preparation method thereof.
For achieving the above object, technical scheme that the present invention adopts is as follows:
The composite whitening spot-dispelling frost, its raw material weight percentage ratio is:
Active Chinese drug component extractive part 1-25%, the different monooctyl ester 0.1-10% of ferulic acid, VCE 0.1-5%, nicotiamide 0.05-3%, oils and fats 10-40%, emulsifying agent 1-6%, wetting agent 1-15%, antiseptic 0.1-1.5%, essence 0.1-0.5%, deionized water 10-80%.Wherein, the raw material weight percent of described active Chinese drug component extractive part is: Semen Vitis viniferae 5-25%, Rhizoma Chuanxiong 5-25%, Flos Moutan 5-25%, Cortex Mori 5-30%, Flos Hibisci Mutabilis 5-35%, Glycyrrhiza glabra L. 5-25%.Described oils and fats is more than at least 4 kinds or 4 kinds of following oils and fats: Dormant oils 6-10%, caprylic/capric triglyceride 3-10%, C12-15 alcohol benzoate 3-10%, Cyclomethicone 4-10%, tocopherol acetas 0.5-1%, polydimethylsiloxane and dimethiconol 0.5-5%, Parleam 2-5%, isopropyl palmitate 1-8%.Described emulsifying agent be in cetyl PEG/PPG-10/1 polydimethylsiloxane 2-3%, lecithin 0.5-1%, methyl glucose sesquistearate 0.5-1.5%, glyceryl stearate 0.1-2%, PEG-10 polydimethylsiloxane 1-3% at least two kinds or more than.Described wetting agent be in 1,3 butylene glycol 3-8%, 1,2-PD 2-8%, glycerol 2-8%, hyaluronate sodium 0.01-0.3%, Anjidew NL50 0.5-2.0%, allantoin 0.1-0.5% at least one or more than.Described antiseptic is that methyl hydroxybenzoate 0.05-0.4%, propylparaben 0.05-0.2%, tri-kinds of materials of phenoxyethanol 0.1-1.5% form.
Preferably, the percetage by weight of described composite whitening spot-dispelling frost raw material is:
Active Chinese drug component extractive part 15%, the different monooctyl ester 5% of ferulic acid, VCE 2%, nicotiamide 1.8%, oils and fats 24%, emulsifying agent 3.5%, wetting agent 6.3%, antiseptic 0.6%, essence 0.2%, surplus is deionized water.Wherein, the raw material weight percent of described active Chinese drug component extractive part is: Semen Vitis viniferae 20%, Rhizoma Chuanxiong 20%, Flos Moutan 10%, Cortex Mori 20%, Flos Hibisci Mutabilis 12%, Glycyrrhiza glabra L. 18%.Described oils and fats is: Dormant oils 6%, caprylic/capric triglyceride 4%, C12-15 alcohol benzoate 6%, Cyclomethicone 6%, polydimethylsiloxane and dimethiconol 2%.Described emulsifying agent is lecithin 0.6%, methyl glucose sesquistearate 1.2%, PEG-10 polydimethylsiloxane 1.7%.Described wetting agent is 1,3 butylene glycol 6%, hyaluronate sodium 0.1%, allantoin 0.2%.Described antiseptic is methyl hydroxybenzoate 0.2%, propylparaben 0.05%, phenoxyethanol 0.5%.
The manufacture method of composite whitening spot-dispelling frost comprises the following steps:
(1) method for extraction and purification of active Chinese drug component extractive part is:
It is in 10-85% ethanol that the active Chinese drug component extractive part raw material of Semen Vitis viniferae, Rhizoma Chuanxiong, Flos Moutan, Cortex Mori, Flos Hibisci Mutabilis, Glycyrrhiza glabra L. is soaked in to concentration according to the medicine of 1:5 to 1:15 and solvent ratios, and soak time is 24-96 hour;
Then filter, by filtrate in 50 ℃ of-80 ℃ of decompression recycling ethanols to without after alcohol flavor, add 2-5 times of water gaging dilution, the macroporous resin column that to go up the resin model be D101 or AB-8 again wash colourless after, colourless to eluent with the 20%-80% ethanol elution again, and the collection ethanol elution, then with the medical material ratio, be 1:2 to 1:10 in 50 ℃ of-80 ℃ of decompression recycling ethanols to medicinal liquid, make the active Chinese drug component extractive part;
(2) described active Chinese drug component extractive part, wetting agent, antiseptic, deionized water are added in the water pot, be heated to 80-85 ℃, stirring and dissolving, be water;
(3) the oiliness materials such as the different monooctyl ester of ferulic acid, VCE, nicotiamide, oils and fats, emulsifying agent being added to the oil phase pot, be heated with stirring to 80-85 ℃, disperse fully rear suction emulsifying pot, is oil phase;
(4) in the slow suction emulsifying of the process filter screen of the material in water pot pot, carrying out emulsifying, after emulsifying 15-40 minute, stop homogenizing, the open cycle water for cooling, keep stirring and the evacuation froth breaking;
(5) be cooled to 45 ℃, add essence, stir, while continuing to be cooled to 38 ℃, discharging, get product.
Preferably, in the manufacture method of described composite whitening spot-dispelling frost: also comprise before the step that described active Chinese drug component extractive part raw material powder is broken into to coarse powder in described step (1).
Preferably, in the manufacture method of described composite whitening spot-dispelling frost: the concentration of alcohol for soaking active Chinese drug component extractive part raw material in described step (1) is 50%, described active Chinese drug component extractive part raw material and proportion of ethanol are 1:10, and described soak time is 48 hours.
Preferably, in the manufacture method of described composite whitening spot-dispelling frost: the concentration of alcohol for eluting in described step (1) is 70%.
Composite whitening spot-dispelling frost prepared by the present invention is the combination of plurality of Chinese composition, whitening and speckle dispelling active component and cosmetics matrix components commonly used.Wherein, Semen Vitis viniferae extract contains abundant vitamin E, has very strong anti-oxidation function, and has antiallergic, radioprotective, protection skin, the effects such as looks improving and the skin nourishing.Rhizoma Chuanxiong extract has very strong function of promoting blood circulation to disperse blood clots, and the energy blood circulation promoting has very strong restraint of tyrosinase active function simultaneously.The Glycyrrhiza glabra L. extract contains the compositions such as glabridin, there is very strong restraint of tyrosinase activity and the effect of check melanin cell, can effectively prevent melanic generation and over-deposit, simultaneously can also effectively decompose, reduce the melanin formed in skin.Flos Moutan, Cortex Mori, Flos Hibisci Mutabilis have the activity of extremely strong restraint of tyrosinase, the effectively generation of check melanin, the melanin that desalination has formed.The different monooctyl ester of ferulic acid is a kind of efficient whitening agent that integrates antioxidation, restraint of tyrosinase and three kinds of effects of absorption ultraviolet, and its oxidation resistance is 4 times of vitamin E; Can effectively isolate the ultraviolet radiation of 280-360nm wave band, there is extraordinary sun-proof result; The potent inhibition restraint of tyrosinase of energy, DHICA enzyme isoreactivity, have potent whitening effect.VCE has following effect and performance: tyrosinase activity inhibition stops melanin synthetic, efficient whitening and speckle dispelling; Promote collagen protein synthesis, improve the intensely dark pool of skin, give skin elasticity; Powerful antioxidation, effectively remove the free radical in skin; The inflammation that antisum causes, have stronger antibacterial and anti-inflammation functions; Have oleophylic and hydrophilic-structure, be easy to skin and absorb, skin corium can go directly; Good stability, fast light, heat-resisting, acidproof, alkaline-resisting, salt tolerant and air oxidation.Nicotiamide is
cosmetic dermatologythe skin anti-aging composition that field is generally acknowledged, its most important effect aspect skin anti-aging is prevention and alleviates the dull and yellow gas of the colour of skin that skin produces in aging course in early days, can promote that the melanin generated excretes fast.Cosmetics are commonly used matrix components, as oils and fats is skin lubrication agent and effective ingredient penetrating agent; Wetting agent can efficiently keep moisture of skin, also can promote that effective ingredient is absorbed by the skin.
The theory of the composite whitening spot-dispelling frost application combination of Chinese and Western medicine of the present invention, added the plurality of Chinese active component in the whitening and speckle dispelling active matter, by the collaborative effect mutually of active ingredient of Chinese herbs and other whitening and speckle dispelling active matter, energy is the activity of restraint of tyrosinase effectively, high-efficient cleaning is except oxygen-derived free radicals, prevent melanic generation, decompose the melanin that desalination has formed, hormonal system that simultaneously can balance the body, the damage that reparation causes skin due to chemical compositions such as hormones, thus reach comprehensively fast, the effect for the treatment of both the principal and secondary aspects of a disease.Composite whitening spot-dispelling frost of the present invention, containing to the human body poisonous and harmful substance, is not a kind of product safely and effectively.
The specific embodiment
Describe the present invention in detail below in conjunction with specific implementation method, in exemplary embodiment and description of the present invention, be used for explaining the present invention, but not as a limitation of the invention.
embodiment 1: the composite whitening spot-dispelling frost
The present embodiment discloses formula of composite whitening spot-dispelling frost and preparation method thereof, and its formula is shown in Table 1.
Table 1
Wherein, the raw material weight percent of described active Chinese drug component extractive part is: Semen Vitis viniferae 20%, Rhizoma Chuanxiong 20%, Flos Moutan 10%, Cortex Mori 20%, Flos Hibisci Mutabilis 12%, Glycyrrhiza glabra L. 18%.
The composite whitening spot-dispelling frost manufacture method of the present embodiment is achieved in that
(1) method for extraction and purification of active Chinese drug component extractive part is:
The mixed powder of the raw material of Semen Vitis viniferae, Rhizoma Chuanxiong, Flos Moutan, Cortex Mori, Flos Hibisci Mutabilis, Glycyrrhiza glabra L. is broken into to coarse powder, and being soaked in concentration according to the ratio of the medicine of 1:8 and solvent ratios is in 40% ethanol, and soak time is 24 hours;
Then filter, by filtrate in 60 ℃ of decompression recycling ethanols to without after alcohol flavor, add 2 times of water gaging dilutions, the macroporous resin column that to go up the resin model be D101 again wash colourless after, colourless to eluent with 60% ethanol elution again, and the collection ethanol elution, then with the medical material ratio, be 1:5 in 60 ℃ of decompression recycling ethanols to medicinal liquid, make the active Chinese drug component extractive part;
(2) water-phase components such as described active Chinese drug component extractive part, deionized water are added in the water pot, be heated to 85 ℃, stirring and dissolving, be water;
(3) oil-phase components such as Dormant oils, the different monooctyl ester of ferulic acid, VCE, nicotiamide, cetyl PEG/PPG-10/1 polydimethylsiloxane, lecithin being added to the oil phase pot, be heated with stirring to 85 ℃, disperse fully rear suction emulsifying pot, is oil phase;
(4) in the slow suction emulsifying of the process filter screen of the material in water pot pot, carrying out emulsifying, emulsifying stopped homogenizing after 25 minutes, and the open cycle water for cooling keeps stirring and the evacuation froth breaking;
(5) be cooled to 45 ℃, add essence, stir, while continuing to be cooled to 38 ℃, discharging, get product.
embodiment 2: the composite whitening spot-dispelling frost
The present embodiment discloses formula of composite whitening spot-dispelling frost and preparation method thereof, and its formula is shown in Table 2.
Table 2
Wherein, the raw material weight percent of described active Chinese drug component extractive part is: Semen Vitis viniferae 18%, Rhizoma Chuanxiong 18%, Flos Moutan 10%, Cortex Mori 20%, Flos Hibisci Mutabilis 15%, Glycyrrhiza glabra L. 19%.
The manufacture method of the described invention of the embodiment of the present invention is substantially the same manner as Example 1, difference is: in described step (1), for the concentration of alcohol that soaks medicated powder, be 60%, described active Chinese drug component extractive part raw material and proportion of ethanol are 1:10, described soak time is 20 hours, and the described concentration of alcohol for eluting is 75%.
embodiment 3: the composite whitening spot-dispelling frost
The present embodiment discloses formula of composite whitening spot-dispelling frost and preparation method thereof, and its formula is shown in Table 3.
Table 3
Wherein, the raw material weight percent of described active Chinese drug component extractive part is: Semen Vitis viniferae 15%, Rhizoma Chuanxiong 23%, Flos Moutan 15%, Cortex Mori 20%, Flos Hibisci Mutabilis 12%, Glycyrrhiza glabra L. 15%.
The manufacture method of the described invention of the embodiment of the present invention is substantially the same manner as Example 1, and difference is: the concentration of alcohol that is immersion medicated powder is 50%, and soak time is 30 hours.During purification, the macroporous resin model is AB-8, and the concentration of alcohol of eluting macroporous resin column is 70%.
embodiment 4: the whitening and speckle dispelling effect assessmentevaluation object: the age is the 30-55 middle-aged women in year.Select face that women's 56 examples of the mottles such as chloasma, freckle, butterfly spot, senile plaque are in various degree arranged.
Evaluation methodology: the composite whitening spot-dispelling frost 3-5g that gets embodiment 1 preparation every morning after washed is applied to the position that mottle is arranged on the face, before the sleep in evening, after washed, repastes once, and within 40 days, be a course for the treatment of.
Evaluation criterion: 1. recovery from illness: mottle disappears substantially; 2. produce effects: mottle disappears and takes off more than 50%; 3. effective: mottle disappears and takes off more than 10%, or the mottle color turns light; 4. invalid: as before and after using, not change.
Evaluation result: 18 examples of fully recovering account for 32.1%; Produce effects 29 examples, account for 51.8%; Effective 7 examples, account for 12.5%; Invalid 2 examples, account for 3.6%.Total effective rate reaches 96.4%.
Claims (2)
1. composite whitening spot-dispelling frost, it is characterized in that raw material weight percentage ratio is: active Chinese drug component extractive part 1-25%, the different monooctyl ester 0.1-10% of ferulic acid, VCE 0.1-5%, nicotiamide 0.05-3%, oils and fats 10-40%, emulsifying agent 1-6%, wetting agent 1-15%, antiseptic 0.1-1.5%, essence 0.1-0.5%, deionized water 10-80%, wherein, the raw material weight percent of described active Chinese drug component extractive part is: Semen Vitis viniferae 5-25%, Rhizoma Chuanxiong 5-25%, Flos Moutan 5-25%, Cortex Mori 5-30%, Flos Hibisci Mutabilis 5-35%, Glycyrrhiza glabra L. 5-25%, described oils and fats is following oils and fats more than at least 4 kinds or 4 kinds: Dormant oils 6-10%, caprylic/capric triglyceride 3-10%, C12-15 alcohol benzoate 3-10%, Cyclomethicone 4-10%, tocopherol acetas 0.5-1%, polydimethylsiloxane and dimethiconol 0.5-5%, Parleam 2-5%, isopropyl palmitate 1-8%, described emulsifying agent is cetyl PEG/PPG-10/1 polydimethylsiloxane 2-3%, lecithin 0.5-1%, methyl glucose sesquistearate 0.5-1.5%, glyceryl stearate 0.1-2%, in PEG-10 polydimethylsiloxane 1-3% at least two kinds or more than, described wetting agent is 1,3 butylene glycol 3-8%, 1,2-PD 2-8%, glycerol 2-8%, hyaluronate sodium 0.01-0.3%, Anjidew NL50 0.5-2.0%, at least one in allantoin 0.1-0.5% or more than, described antiseptic is methyl hydroxybenzoate 0.05-0.4%, propylparaben 0.05-0.2%, tri-kinds of materials of phenoxyethanol 0.1-1.5% form.
2. the manufacture method of composite whitening spot-dispelling frost claimed in claim 1 is characterized in that comprising the following steps:
(1) method for extraction and purification of active Chinese drug component extractive part is: it is in 10-85% ethanol that the active Chinese drug component extractive part raw material of Semen Vitis viniferae, Rhizoma Chuanxiong, Flos Moutan, Cortex Mori, Flos Hibisci Mutabilis, Glycyrrhiza glabra L. is soaked in to concentration according to the medicine of 1:5 to 1:15 and solvent ratios, and soak time is 24-96 hour; Then filter, by filtrate in 50 ℃ of-80 ℃ of decompression recycling ethanols to without after alcohol flavor, add 2-5 times of water gaging dilution, the macroporous resin column that to go up the resin model be D101 or AB-8 again wash colourless after, colourless to eluent with the 20%-80% ethanol elution again, and the collection ethanol elution, then with the medical material ratio, be 1:2 to 1:10 in 50 ℃ of-80 ℃ of decompression recycling ethanols to medicinal liquid, make the active Chinese drug component extractive part;
(2) described active Chinese drug component extractive part, wetting agent, antiseptic, deionized water are added in the water pot, be heated to 80-85 ℃, stirring and dissolving, be water;
(3) the oiliness materials such as the different monooctyl ester of ferulic acid, VCE, nicotiamide, oils and fats, emulsifying agent being added to the oil phase pot, be heated with stirring to 80-85 ℃, disperse fully rear suction emulsifying pot, is oil phase;
(4) in the slow suction emulsifying of the process filter screen of the material in water pot pot, carrying out emulsifying, after emulsifying 15-40 minute, stop homogenizing, the open cycle water for cooling, keep stirring and the evacuation froth breaking;
(5) be cooled to 45 ℃, add essence, stir, while continuing to be cooled to 38 ℃, discharging, get product.
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