CN108379339A - A kind of preparation method of the antibacterial blemish clearing gel of multiple target point - Google Patents
A kind of preparation method of the antibacterial blemish clearing gel of multiple target point Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract
The present invention provides a kind of preparation methods of the antibacterial blemish clearing gel of multiple target point, including：Configure the pre-dispersed solution of thickener；70% purified water of said preset amount of water is added in container, is stirred and heated to 80 90 DEG C, the pre-dispersed solution of thickener is added and carries out homogeneous, obtains homogenizing fluid；Homogenizing fluid is cooled down, reaches 40 50 DEG C, obtains half coolant liquid；After multiple target point functional drug and emulsifier are pre-mixed, it is added in half coolant liquid, emulsion is obtained after stirring；Multiple target point functional drug includes soluble substance and insoluble material；In emulsion be added essence and said preset amount of water 30% purified water, after stirring stand solidification to get.The present invention realize multiple target point functional drug in insoluble material and soluble substance uniform dissolution in the antibacterial blemish clearing gel product of multiple target point, avoid in product preparation process due to cannot achieve uniformly, dissolving the problem of.
Description
Technical field
The invention belongs to antibacterial medicines technical field more particularly to a kind of preparation methods of the antibacterial blemish clearing gel of multiple target point.
Background technology
Adolescent acne refers to young men and women caused by the characteristics of puberty is because of hormonal readiness, life style with acne
Based on Propionibacterium, staphylococcus and Malassezia furfur be complicated by infection a kind of inflammation.Clinically mainly acne is divided into
Four types, wherein I and II type is slight symptom, patient is mainly shown as that face has the small acne and small inflammation, III type and IV to be
Serious acne symptom has greater area of abscess, tubercle and scar on the basis of II type.Acne is main occurred frequently in face,
The state at a small amount of patient back is similarly serious.In actual life, face acnes are small, influence appearance, then caused to life greatly
Serious puzzlement, therefore acne causes prodigious influence to teen-age life, according to conservative estimation, in 15-30 Sui age bracket
In crowd, has more than 85% people and declare by acne long-standing problem.
The pattern microorganism of acne has critical effect to acne, and wherein propionibacterium acnes are a kind of colonizations
In the Anaerobic Bacteria of sebaceous glands, its internal male sex hormone (predominantly testosterone) is easy in hair follicle and skin when patient is in puberty
The 5α-reductase of adipose gland is converted into the stronger dihydrotestosterone of activity, and dihydrotestosterone is easier to be combined with neighbouring androgen receptor
And chain biochemical reaction is excited, it is embodied in sebaceous gland duct and the excessive keratinization of hair follicle cell, and then enclose sebum
Gland conduit or hair follicle conduit, cause the anaerobism microenvironment of sebaceous glands, and then the propionibacterium acnes advantage in sebaceous glands is caused to be given birth to
It is long.
It more degrades after propionibacterium acnes dominant growth relevant lipid, degradation is formed with the fat of inflammatory factor attribute
Acid, to be that acne forms inflammation.In the generating process of acne, because of skin lesion, the staphylococcus of skin surface and
Malassezia furfur has also assisted in relevant inflammatory reaction, and then adds fuel to the flames, in addition the inappropriate processing of patient (such as uses hand
Scratch, squeeze acne etc.), form the symptoms such as more abscess and tubercle.
The existing anti-acne externally applied product with bacteria resistance function in the preparation, wherein contain great amount of soluble and insolubility
Functional materials, cannot achieve in product preparation process uniformly, dissolving, can not be played in product when user uses
Functional materials the effect of, can not efficiently reach thin for propionibacterium acnes, staphylococcus and Malassezia furfur etc.
The inhibiting effect of bacterium.
Invention content
To solve the above problems, the present invention provides a kind of preparation method of the antibacterial blemish clearing gel of multiple target point, including：
Configure the pre-dispersed solution of thickener；
70% purified water of said preset amount of water is added in container, is stirred and heated to 80-90 DEG C, the thickener is added
Pre-dispersed solution carries out homogeneous, obtains homogenizing fluid；
The homogenizing fluid is cooled down, reaches 40-50 DEG C, obtains half coolant liquid；
After multiple target point functional drug and emulsifier are pre-mixed, it is added in half coolant liquid, is obtained after stirring
Emulsion；The multiple target point functional drug includes soluble compounds and insoluble compound；
30% purified water of essence and the said preset amount of water is added in the emulsion, solidification is stood after stirring, i.e.,
Obtain the antibacterial blemish clearing gel of the multiple target point.
Preferably, the soluble compounds include jamaicin, paeonol；
The insoluble compound includes Cineole and eugenol；
The multiple target point functional drug further includes：Plant extracts, whitening agent, moisturizing renovation agent and bacteriostatic agent；
The plant extracts includes licorice and Gotu Kola P.E；
The whitening agent includes niacinamide and Victoria C ethylether；
The moisturizing renovation agent includes ceramide, phytosphingosine and allantoin；
The bacteriostatic agent includes dodecyl benzyl dimethyl ammonium chloride and polyaminopropyl biguanide.
Preferably, the plant extracts further includes grape seed extract, apple pomace extract and the extraction of mango pomace
Object.
Preferably, the emulsifier is match Bick；It is described " to be pre-mixed multiple target point functional drug and emulsifier
Afterwards, it is added in half coolant liquid, emulsion is obtained after stirring " include：
Cineole and eugenol are taken, is mixed with emulsifier, oiliness emulsion is obtained；Also,
To be reduced incremental method by jamaicin, paeonol, niacinamide, Victoria C ethylether, ceramide, phytosphingosine, allantois
Element, dodecyl benzyl dimethyl ammonium chloride, polyaminopropyl biguanide are mixed, and medicinal mixture is obtained；
Oiliness emulsion, medicinal mixture, Radix Glycyrrhizae extraction is added to be incremented by principle by amount successively into half coolant liquid
Object, Gotu Kola P.E, grape seed extract, apple pomace extract and mango pomace extract, and be stirred, it obtains
To emulsion.
Preferably, described " after being pre-mixed multiple target point functional drug and emulsifier, half coolant liquid to be added
In, emulsion is obtained after stirring " before, further include：
Extracting liquorice and centella crush respectively, obtain Radix Glycyrrhizae extraction raw material and centella extraction raw material；Also, by Portugal
Grape seed, apple pomace and mango pomace are dried；
Radix Glycyrrhizae extraction raw material is extracted using microwave alcohol extracting method, obtains the licorice；Utilize macropore
Absorption resins extraction method extracts centella extraction raw material, obtains the Gotu Kola P.E；Utilize high-speed counter-current
Chromatography extracts grape pip, apple pomace and mango pomace respectively, obtains grape seed extract, apple pomace extract
With mango pomace extract.
Preferably, described " Radix Glycyrrhizae extraction raw material to be extracted using microwave alcohol extracting method, obtains the Radix Glycyrrhizae extraction
Object " includes：
Extracting liquorice extracts raw material, after being impregnated with 60% ethyl alcohol, by Microwave Extraction 3 times, 1 hour every time, merges microwave and carries
Liquid is taken, the licorice is obtained after concentration；
It is described " centella extraction raw material to be extracted using macroporous absorbent resin extraction method, obtains the accumulated snow
Careless extract " includes：
After taking the centella raw material to be extracted by 70% ethyl alcohol, centella ethanol extract is obtained, then by the accumulated snow
Careless ethanol extract is purified by macroporous absorbent resin, and mobile phase is 70% ethyl alcohol, is eluted defensive position machine eluate and is carried out
Concentration is to get to the licorice.
Preferably, described " grape pip, apple pomace and mango pomace to be extracted respectively using supercritical extract, obtained
To grape seed extract, apple pomace extract and mango pomace extract " include：
It takes the ethyl alcohol that grape pip, apple pomace and mango pomace are separately added into 60-70% to be impregnated, extracts to obtain second
Alcohol extracting thing, and extracted 3 times by high speed adverse current chromatogram hair, merge extracting solution, grape pip extraction is respectively obtained after concentration
Object, apple pomace extract and mango pomace extract.
Preferably, described " after being pre-mixed multiple target point functional drug and emulsifier, half coolant liquid to be added
In, emulsion is obtained after stirring " in, the mixing time being added after multiple target point functional drug and emulsifier is 25-35 minutes；
It is described " 30% purified water of essence and the said preset amount of water to be added in the emulsion, is stood after stirring solid
Change to get to the antibacterial blemish clearing gel of the multiple target point " in, the 30% of essence and the said preset amount of water is added in the emulsion
Purified water and the mixing time that is stirred be 5-15 minutes.
Preferably, described " the pre-dispersed solution of configuration thickener " includes：
10-20 parts of glycerine are taken to be mixed with 15-30 parts of thickener, homogeneous is stirred until homogeneous dispersion, mixing time 25-35
Minute to get to the pre-dispersed solution of the thickener；
The thickener is Acritamer 940.
Preferably,
Said preset amount of water is 5-10 times of multiple target point functional drug and emulsifier total weight.
The present invention provides a kind of preparation method of the antibacterial blemish clearing gel of multiple target point, including：Configure the pre-dispersed solution of thickener；
70% purified water of said preset amount of water is added in container, is stirred and heated to 80-90 DEG C, it is pre-dispersed that the thickener is added
Solution carries out homogeneous, obtains homogenizing fluid；The homogenizing fluid is cooled down, reaches 40-50 DEG C, obtains half coolant liquid；By more targets
After point functional drug and emulsifier are pre-mixed, it is added in half coolant liquid, emulsion is obtained after stirring；More targets
Point functional drug includes soluble compounds and insoluble compound；Essence and the said preset amount of water are added in the emulsion
30% purified water, solidification is stood after stirring to get to the antibacterial blemish clearing gel of the multiple target point.The present invention passes through in the hot water
Thickening agent dispersing liquid is added, and multiple target point functional drug and emulsifier are pre-mixed, is added after the cooling of half coolant liquid
And mix, so that the insoluble substance in multiple target point functional drug is realized solubilising by the lipophilic group in emulsifier first,
It realizes in the preparation process of the antibacterial blemish clearing gel of multiple target point, the insoluble material in multiple target point functional drug and soluble matter
Matter uniform dissolution in the antibacterial blemish clearing gel product of multiple target point, avoid in product preparation process due to cannot achieve uniformly,
The effect of dissolving, the functional materials in product can not be played when user uses, can not efficiently reach for acne
The problem of inhibiting effect of the bacteriums such as Propionibacterium, staphylococcus and Malassezia furfur.
Description of the drawings
Fig. 1 is patient using the antibacterial anti-acne of multiple target point prepared by the antibacterial blemish clearing gel preparation method of multiple target point of the present invention
Affected part situation map before gel；
Fig. 2 is patient using the antibacterial anti-acne of multiple target point prepared by the antibacterial blemish clearing gel preparation method of multiple target point of the present invention
Affected part situation map of the gel after 24 hours；
Fig. 3 is patient using the antibacterial anti-acne of multiple target point prepared by the antibacterial blemish clearing gel preparation method of multiple target point of the present invention
Affected part situation map of the gel after 72 hours.
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific implementation mode
Technical scheme of the present invention is described in further detail with reference to the mode of specific embodiment, but not structure
At any limitation of the invention, the modification of anyone limited number of time made within the scope of the invention as claimed, still in this hair
Within bright right.
To solve the above problems, the present invention provides a kind of preparation method of the antibacterial blemish clearing gel of multiple target point, including：
Configure the pre-dispersed solution of thickener；
70% purified water of said preset amount of water is added in container, is stirred and heated to 80-90 DEG C, the thickener is added
Pre-dispersed solution carries out homogeneous, obtains homogenizing fluid；
The homogenizing fluid is cooled down, reaches 40-50 DEG C, obtains half coolant liquid；
After multiple target point functional drug and emulsifier are pre-mixed, it is added in half coolant liquid, is obtained after stirring
Emulsion；The multiple target point functional drug includes soluble compounds and insoluble compound；
30% purified water of essence and the said preset amount of water is added in the emulsion, solidification is stood after stirring, i.e.,
Obtain the antibacterial blemish clearing gel of the multiple target point.
Above-mentioned, the purified water in the present embodiment is that two-stage reverse osmosis water purification equipment system is used in 100,000 grades of cleaning shops
The amount of preparing enough pure water.
It is above-mentioned, it needs to use homogenizer, such as homogenizer when preparing homogenizing fluid, can be high pressure homogenizer, it can also
For normal pressure homogenizer.
Above-mentioned, the pre-dispersed solution of thickener is the solvent after being disperseed using thickener, wherein thickener is a kind of food additive
Add agent, be mainly used for improving and increasing the viscosity of food, keep the color and stability of fluidised form food, jelly food,
Improve food physical behavior, and food can be made to have and lubricate agreeable to the taste feeling.Thickener can be improved the viscosity of food or be formed solidifying
Glue assigns the glutinous profit of food, suitable mouthfeel to change the physical behavior of food, and has emulsification, stabilization concurrently or make to be in suspension
The effect of state, the thickener kind that China ratifies to use at present have 39 kinds.Thickener is all hydrophilic macromolecular compounds, also referred to as
The hydrosol.It can be divided into natural and chemical synthesis (including semi-synthetic) two major classes by its source.
Above-mentioned, container can be production preparation tank, or in the stirring bucket of reaction kettle or blender.
Above-mentioned, said preset amount of water can be 2-10 times of total amount of all solids reagent in the present embodiment, it is preferred that can be with
It is 3-5 times, is in this embodiment 4 times.Specifically, be subject to practical operation when solid reagent viscosity.
Above-mentioned, the homogenizing time of homogenizing fluid can be 2-20 minutes, preferably 5-15 minutes, in the present embodiment, use
Homogenizing time be 5 minutes.
Above-mentioned, half coolant liquid needs to carry out cooling processing, can be to be placed by normal temperature and pressure to reach cooling purpose,
Can be that rapid cooling is realized by water cooling equipment or air cooler.
The present invention carries out in advance by the way that thickening agent dispersing liquid is added in the hot water, and by multiple target point functional drug and emulsifier
Mixing is added and mixes after the cooling of half coolant liquid, the insoluble substance in multiple target point functional drug is made to pass through breast first
Lipophilic group in agent realizes solubilising, realizes in the preparation process of the antibacterial blemish clearing gel of multiple target point, and multiple target point is functional
Insoluble material and soluble substance uniform dissolution in drug avoid in the antibacterial blemish clearing gel product of multiple target point in product system
Due to cannot achieve uniform, dissolving during standby, the work(of the functional materials in product can not be played when user uses
Effect can not efficiently not reach and the inhibiting effect of the bacteriums such as propionibacterium acnes, staphylococcus and Malassezia furfur is asked
Topic.
Preferably, the soluble compounds include jamaicin, paeonol；
The insoluble compound includes Cineole and eugenol；
The multiple target point functional drug further includes：Plant extracts, whitening agent, moisturizing renovation agent and bacteriostatic agent；
The plant extracts includes licorice and Gotu Kola P.E；
The whitening agent includes niacinamide and Victoria C ethylether；
The moisturizing renovation agent includes ceramide, phytosphingosine and allantoin；
The bacteriostatic agent includes dodecyl benzyl dimethyl ammonium chloride and polyaminopropyl biguanide.
It is above-mentioned, it should be noted that jamaicin is yellow crystalline powder；Odorless, taste is extremely bitter.It dissolves in the hot water,
Slightly soluble in water or ethyl alcohol, the soluble,very slightly in chloroform are insoluble in ether.It is experimentally confirmed, jamaicin is to hemolytic
Streptococcus, staphylococcus aureus, gonococcus and Freund, Shigella shigae etc. have antibacterial action, and have the white blood of enhancing
Ball phagocytosis also has tubercle bacillus, plague bacillus different degrees of inhibiting effect, also has inhibition to imitate the amoeba bacterium of rat
With.
Above-mentioned, paeonol is colorless needle crystals, and 49 DEG C -51 DEG C of fusing point is slightly dissolved in water, dissolves in the hot water, do not dissolve in
Cold water can volatilize with vapor, be dissolved in ethyl alcohol, ether, acetone, chloroform, benzene and carbon disulfide.Smell is special, the micro- peppery storage of taste
Condition：Cool place, is protected from light drying.It is experimentally confirmed, paeonol is to the inhibition concentration of staphylococcus aureus and streptococcus fecalis
500ug/ml, the inhibition concentration to Escherichia coli and Bacillus subtilis are 200ug/ml.Inhibition concentration to trichophyton interdigitalis is
250ug/ml。
It is above-mentioned, it should be noted that Cineole is colourless to pale yellow oily liquid, there is camphor and refrigerant herbal medicine gas
Taste, molecular weight 154.28,176-177 DEG C of boiling point, 1-1.5 DEG C of fusing point, 1 DEG C of solidification point, 47-48 DEG C of flash-point, index of refraction (n20D)
For 1.455-1.460, relative density (d2525) is 0.921-0.924.Cineole dissolves in ether, chloroform, glacial acetic acid, the third two
Alcohol, is slightly soluble in water, and 1mL Cineoles dissolve in 60% ethyl alcohol of 5mL.Niacinamide is also referred to as vitamin B5, helps the formation of cell,
The development for maintaining normal development and central nervous system, contributes to wound healing effect.
It is above-mentioned, it should be noted that eugenol molecular formula is C10H12O2, it is colourless or pale yellow liquid, there is strong fourth
Fragrance, it is not soluble in water.It is mainly used for antibacterial, blood pressure lowering.
Above-mentioned, eugenol, Cineole are that insoluble compound needs in the preparation for carrying out the antibacterial blemish clearing gel of multiple target point
Insoluble matter and emulsifier are pre-mixed first, include lipophilic group in emulsifier, thus by not soluble in water or slightly soluble
Dispersion is uniformly mixed with emulsifier in eugenol, the Cineole of water, to realize the uniform mixing of insoluble compound in the product.
Above-mentioned, niacinamide is also vitamin B5, helps the formation of cell, maintains the hair of normal development and central nervous system
It educates, contributes to wound healing effect.
Above-mentioned, allantoin has as renovation agent and promotes cell growth, accelerates wound healing.Cutin-softening albumen etc. is raw
Function is managed, is the good consolidant and antiulcer agents of skin trauma.It can be used as alleviating and treating xerodermia, scaling skin
Illness, skin ulcer, digestive tract ulcer and inflammation have good therapeutic effect to osteomyelitis, diabetes, hepatic sclerosis, acne.
Above-mentioned, ceramide and phytosphingosine can be rebuild " brick wall structure " by improving skin sparing barrier, make flesh
Skin tends to develop in a healthy way, and has good improvement for slight dermatitis.
Above-mentioned, dodecyl benzyl dimethyl ammonium chloride and poly- ammonia is refined and biguanides is preservative can improve blemish clearing gel
Bacteriostasis property.
Above-mentioned, emulsifier is that can improve the various surface tension constituted between phase in emulsion, is allowed to be formed uniformly steady
The substance of fixed dispersion or emulsion.Emulsifier is surface reactive material, has hydrophilic group and lipophilic group simultaneously in molecule,
It is gathered on oil/water interface, can reduce interfacial tension and reduction forms the required energy of emulsion, to improve emulsus
The energy of liquid.In the present embodiment, used emulsifier is SIMULGEL INS 100, is that match BIC Corp of France provides
Emulsifier, be it is a can it is cold with operation efficient emulsifier.
Preferably, the plant extracts further includes grape seed extract, apple pomace extract and the extraction of mango pomace
Object.
It is above-mentioned, use grape seed extract, apple pomace extract and mango pomace extract as more targets in the present invention
One of the functional components of the antibacterial blemish clearing gel of point, wherein grape pip, apple pomace and mango pomace are that food processing is useless
Material, but be experimentally confirmed in these food processing waste materials and contain a large amount of antioxidant content.
Wherein, apple pomace is residue of the fresh apple after being crushed squeeze juice extracting, mainly by pericarp, fruit stone and remnants
Pulp forms, containing the nutriment that soluble sugar, vitamin, minerals and cellulose etc. are abundant, wherein containing a large amount of more
Aldehydes matter, with a variety of including anti-aging, boat tumour, anti-mutation, antiatherosclerosis, placement coronary heart disease and apoplexy etc.
Pharmacological function, and polyphenols therein, then be oxidation resistant main component.
Mango pomace is fresh mango by after pulp detaches and squeezes the juice, remaining pericarp, fruit stone, pulp residuals,
Containing substances such as a large amount of monosaccharide, polysaccharide, vitamins, in addition wherein there are a large amount of phenolic compounds, including polyphenol compound,
With very strong antioxidation.
Grape pip is the seed of grape, is the leftover bits and pieces of grape wine factory, and gained after Grape Skin, grape pedicel is detached after drying
Product.Grape pip contains abundant amino acid, vitamin and minerals etc., has the effect of health care, beauty.
By the present invention in that with the leftover bits and pieces in the food processing process such as apple pomace, mango pomace and grape pip, carry out
Waste utilization, by extracting and purifying flow, on the one hand the oxidation resistant main component to wherein be contained makes multiple target point
Antibacterial blemish clearing gel during user's use, a large amount of antioxidant can be made to go deep into skin to reach further it is anti-oxidant and
Anti-aging function is achieved many things at one stroke；On the other hand, it is the leftover bits and pieces preparation external application in food processing process using moral in the present invention
The gel of anti-aging, realize waste utilization, realize and can be improved this product it is functional under the premise of, reduce production cost,
The waste of resource and the pollution to environment are greatly reduced, it is more environmentally-friendly.
Preferably, the emulsifier is match Bick；It is described " to be pre-mixed multiple target point functional drug and emulsifier
Afterwards, it is added in half coolant liquid, emulsion is obtained after stirring " include：
Cineole and eugenol are taken, is mixed with emulsifier, oiliness emulsion is obtained；Also,
To be reduced incremental method by jamaicin, paeonol, niacinamide, Victoria C ethylether, ceramide, phytosphingosine, allantois
Element, dodecyl benzyl dimethyl ammonium chloride, polyaminopropyl biguanide are mixed, and medicinal mixture is obtained；
Oiliness emulsion, medicinal mixture, Radix Glycyrrhizae extraction is added to be incremented by principle by amount successively into half coolant liquid
Object, Gotu Kola P.E, grape seed extract, apple pomace extract and mango pomace extract, and be stirred, it obtains
To emulsion.
It is above-mentioned, decrement incremental method be the minimum material of the total amount in material to be mixed is divided into several pieces, and by other
Material is multiplied step by step according to above-mentioned number, after being stirred, above-mentioned a few minutes material is mixed, so that total amount is most
Few material is sufficiently mixed among all materials.
It is above-mentioned, Bick is matched, SIMULGEL INS 100 are the emulsifiers that match BIC Corp of France provides, and are that a cold can match
The efficient emulsifier of operation.
It is above-mentioned, when into multiple target point functional drug is about to and emulsifier is pre-mixed, as by it is not soluble in water not
Molten compound is mixed well with emulsifier.Wherein, insoluble compound includes Cineole and eugenol, after being mixed with emulsifier
To obtain oiliness emulsion.Also, simultaneously by soluble compounds and niacinamide, Victoria C ethylether, ceramide, plant sheath ammonia
Alcohol, allantoin, dodecyl benzyl dimethyl ammonium chloride, polyaminopropyl biguanide are mixed, and medicinal mixture is obtained.Xiang Banleng
But in liquid, oiliness emulsion, medicinal mixture, licorice, Gotu Kola P.E, grape seed extract, apple are sequentially added
Fruit pomace extract and mango pomace extract, and to get to emulsion after being sufficiently stirred.
In addition, when being stirred, if when being mixed, emulsion stability is bad, then can be pre-mixed
When material is suitably heated, for example, oiliness emulsion is heated to 60 DEG C upon mixing, then add in half coolant liquid
It is sufficiently stirred, to realize the stability of the emulsification of mixture.
Preferably, described " after being pre-mixed multiple target point functional drug and emulsifier, half coolant liquid to be added
In, emulsion is obtained after stirring " before, further include：
Extracting liquorice and centella crush respectively, obtain Radix Glycyrrhizae extraction raw material and centella extraction raw material；Also, by Portugal
Grape seed, apple pomace and mango pomace are dried；
Radix Glycyrrhizae extraction raw material is extracted using microwave alcohol extracting method, obtains the licorice；Utilize macropore
Absorption resins extraction method extracts centella extraction raw material, obtains the Gotu Kola P.E；Utilize high-speed counter-current
Chromatography extracts grape pip, apple pomace and mango pomace respectively, obtains grape seed extract, apple pomace extract
With mango pomace extract.
It is above-mentioned, before carrying out half coolant liquid of pre-mixed material addition and being stirred mixing, first have to carry out extracting section
The preparation of object, including grape seed extract, apple pomace extract, mango pomace extract, licorice and snow grass extraction
Object.
Preferably, described " Radix Glycyrrhizae extraction raw material to be extracted using microwave alcohol extracting method, obtains the Radix Glycyrrhizae extraction
Object " includes：
Extracting liquorice extracts raw material, after being impregnated with 60% ethyl alcohol, by Microwave Extraction 3 times, 1 hour every time, merges microwave and carries
Liquid is taken, the licorice is obtained after concentration；
It is described " centella extraction raw material to be extracted using macroporous absorbent resin extraction method, obtains the accumulated snow
Careless extract " includes：
After taking the centella raw material to be extracted by 70% ethyl alcohol, centella ethanol extract is obtained, then by the accumulated snow
Careless ethanol extract is purified by macroporous absorbent resin, and mobile phase is 70% ethyl alcohol, is eluted defensive position machine eluate and is carried out
Concentration is to get to the licorice.
Above-mentioned, Radix Glycyrrhizae is during extracting, it may include following steps：
Extracting liquorice obtains Radix Glycyrrhizae extraction raw material, 3-5 times of 60% ethyl alcohol is added after crushing；
The Microwave Extraction 3 times under the conditions of 80 DEG C, microwave power 400W 20 minutes every time, merge supernatant, and led to
The filtering of 200 mesh screens is crossed, is concentrated by decompression drying method, to obtain Radix Glycyrrhizae Microwave Extraction object.
The recovery rate of the obtained licorice of this method is high, and extraction time is shorter, and efficiency is high compared to extractor extraction.
Above-mentioned, Gotu Kola P.E may include steps of during extracting：
Centella is taken, centella extraction raw material is obtained after crushing；
70% ethyl alcohol that 12 times of amounts are added carries out refluxing extraction twice by extractor；
Merge extracting solution twice, is concentrated to give centella asiatica extract；
The centella asiatica extract is dissolved in 3 times of water to dissolve, is filtered after standing, obtains filtrate；
After D101 macroporous absorbent resins are impregnated expansion in 24 hours with 95% ethyl alcohol, wet method dress post；
Using ethanol elution until not muddy, it is changed to massive laundering, it is spare；
By filtrate in washed macroporous absorbent resin loading, and with 70% ethanol elution, collect eluent, and by subtracting
It is 1.1-1.2 to get to Gotu Kola P.E that pressure seasoning, which be concentrated into density,.
The Gotu Kola P.E that this method is extracted eliminates a large amount of pigments wherein contained, and retains centella
In active constituent, the main active in extract is saponins polyphenol compound, and degree of enrichment is high, few containing impurity,
It is easy to operate, it is with short production cycle, and macroporous absorbent resin iterative regenerable uses, and saves industrial cost, can be used for extensive
Industrialized production.
Preferably, described " grape pip, apple pomace and mango pomace to be extracted respectively using supercritical extract, obtained
To grape seed extract, apple pomace extract and mango pomace extract " include：
It takes the ethyl alcohol that grape pip, apple pomace and mango pomace are separately added into 60-70% to be impregnated, extracts to obtain second
Alcohol extracting thing, and extracted 3 times by high speed adverse current chromatogram hair, merge extracting solution, grape pip extraction is respectively obtained after concentration
Object, apple pomace extract and mango pomace extract.
Above-mentioned, the extracting method of apple pomace is as follows：
Apple pomace is dried；
The acid ethanol solution that dry apple pomace is added 5 times is taken to impregnate 1 hour, in 60 DEG C of ultrasonic wave extractions
Under the conditions of, power 100W, extract 3 times, 15 minutes every time, take supernatant merging filtrate, after filtering, be dried under reduced pressure to get
To apple pomace medicinal extract；
Apple pomace medicinal extract is subjected to extraction elution by HSCCC high speed adverse current chromatograms, eluent is ethyl acetate：Positive fourth
Alcohol：Water (9:1:10, V/V/V), wherein solvent system needs after being extracted first and separates phase (stationary phase and flowing up and down
Phase).Specifically, after upper and lower phase solvent is proportionally mixed, stratification is carried out, also, after separation, stand 24 respectively
Hour to get to the solvent of upper and lower phase.
When detached by HSCCC, apple pomace medicinal extract is dissolved in 2 times of water, squeezes into stationary phase successively respectively
And mobile phase, after carrying out high speed rotation in a device, obtained dissolved apple pomace medicinal extract is added, is detached, i.e.,
Obtain apple pomace extract.
Above-mentioned, the extracting method of mango pomace is as follows：
Mango pomace is dried；
The acid ethanol solution that dry mango pomace is added 5 times is taken to impregnate 1.5 hours, in 50-60 DEG C of ultrasonic wave
Under conditions of extraction, power 100W extracts 3 times, 15 minutes every time, takes supernatant merging filtrate, and after filtering, it is dry to carry out decompression
It is dry to get to mango pomace medicinal extract；
Mango pomace medicinal extract is subjected to extraction elution by HSCCC high speed adverse current chromatograms, eluent is ethyl acetate：Positive fourth
Alcohol：Water (1:4:5, V/V/V), wherein solvent system needs after being extracted first and separates phase (stationary phase and flowing up and down
Phase).Specifically, after upper and lower phase solvent is proportionally mixed, stratification is carried out, also, after separation, stand 24 respectively
Hour to get to the solvent of upper and lower phase.
When detached by HSCCC, mango pomace medicinal extract is dissolved in 2 times of water, squeezes into stationary phase successively respectively
And mobile phase, after carrying out high speed rotation in a device, obtained dissolved mango pomace medicinal extract is added, is detached, i.e.,
Obtain mango pomace extract.
It is purified by ultrasonic extraction and by HSCCC, the higher Polyphenols object of mango pomace moderate purity can be obtained
Matter.
Above-mentioned, the extracting method of grape pip is as follows：
Grape pip is taken, after drying in the shade, crushes, obtains grape pip powder particle；
Take grape pip powder particle, 12 times 95% of addition alcohol solution dipping 1 hour；
Under 40W power, ultrasonic extraction 100 minutes takes supernatant, adds 6 times of 95% ethanol solution, extracts 40 points
Clock takes supernatant, merges supernatant twice and carries out 100 mesh filter screen filterings, be dried under reduced pressure, obtains the Portugal that density is 1.1-1.3
Grape seed medicinal extract；
Dissolved grape pip medicinal extract is subjected to extraction elution by HSCCC high speed adverse current chromatograms, eluent is acetic acid second
Ester：N-butanol：Water (9:1:10, V/V/V), wherein solvent system needs after being extracted first and separates phase (stationary phase up and down
And mobile phase).Specifically, after upper and lower phase solvent is proportionally mixed, stratification is carried out, also, after separation, respectively
24 hours are stood to get to the solvent of upper and lower phase.
When detached by HSCCC, grape pip medicinal extract is dissolved in 2 times of water, squeeze into successively respectively stationary phase and
After carrying out high speed rotation in a device, obtained dissolved grape pip medicinal extract is added in mobile phase, detached to get to
Grape seed extract.
It is purified by ultrasonic extraction and by HSCCC, the higher polyphenols of grape pip moderate purity can be obtained.
Preferably, described " after being pre-mixed multiple target point functional drug and emulsifier, half coolant liquid to be added
In, emulsion is obtained after stirring " in, the mixing time being added after multiple target point functional drug and emulsifier is 25-35 minutes；
It is described " 30% purified water of essence and the said preset amount of water to be added in the emulsion, is stood after stirring solid
Change to get to the antibacterial blemish clearing gel of the multiple target point " in, the 30% of essence and the said preset amount of water is added in the emulsion
Purified water and the mixing time that is stirred be 5-15 minutes.
Preferably, described " the pre-dispersed solution of configuration thickener " includes：
10-20 parts of glycerine are taken to be mixed with 15-30 parts of thickener, homogeneous is stirred until homogeneous dispersion, mixing time 25-35
Minute to get to the pre-dispersed solution of the thickener；
The thickener is Acritamer 940.
Preferably,
Said preset amount of water is 5-10 times of multiple target point functional drug and emulsifier total weight.
In order to better illustrate the preparation method of the antibacterial blemish clearing gel of multiple target point provided by the present invention, it is based on above-mentioned preparation
Method, the present invention provide a kind of antibacterial blemish clearing gel of multiple target point.Including：Monomeric compound, plant extracts, whitening agent, moisturizing
Renovation agent, penetration enhancers, bacteriostatic agent, thickener and emulsifier.
Wherein, the monomeric compound includes one or more in berberine, paeonol, Cineole and eugenol.
Preferably,
The plant extracts includes licorice and Gotu Kola P.E.
Preferably,
The whitening agent includes niacinamide and Victoria C ethylether；
The moisturizing renovation agent includes ceramide, phytosphingosine, allantoin and glycerine；
The penetration enhancers include water-solubleazone；
The bacteriostatic agent includes dodecyl benzyl dimethyl ammonium chloride, polyaminopropyl biguanide；
The thickener is Acritamer 940；
The emulsifier is match Bick SIMULGEL INS 100.
Preferably,
Include the component of following parts by weight：
The monomeric compound includes：
0.01-5 parts of berberine；
0.01-5 parts of paeonol；
0.01-10 parts of Cineole；
0.01-8 parts of eugenol；
The plant extracts includes：
0.1-5 parts of licorice；
0.01-5 parts of Gotu Kola P.E；
The moisturizing renovation agent includes：
0.01-1 parts of ceramide；
0.01-1 parts of phytosphingosine；
0.1-3 parts of allantoin；
1-10 parts of glycerine；
The whitening agent includes：
1-5 parts of niacinamide；
0.5-3 parts of Victoria C ethylether；
The penetration enhancers include：
0.1-3 parts of water-solubleazone；
The bacteriostatic agent includes：
0.01-0.3 parts of dodecyl benzyl dimethyl ammonium chloride；
0.1-1 parts of polyaminopropyl biguanide；
The thickener includes：
0.5-3 parts of Acritamer 940；
The emulsifier includes：
Match 0.5-5 parts of Bick SIMULGEL INS 100.
Preferably,
Include the component of following parts by weight：
The monomeric compound includes：
0.05-4.5 parts of berberine；
0.05-3.5 parts of paeonol；
0.1-6 parts of Cineole；
0.05-5 parts of eugenol；
The plant extracts includes：
0.2-1 parts of licorice；
0.01-3 parts of Gotu Kola P.E；
The moisturizing renovation agent includes：
0.02-0.1 parts of ceramide；
0.01-0.05 parts of phytosphingosine；
0.1-0.2 parts of allantoin；
1-5 parts of glycerine；
The whitening agent includes：
1-3 parts of niacinamide；
0.5-2 parts of Victoria C ethylether；
The penetration enhancers include：
0.5-1 parts of water-solubleazone；
The bacteriostatic agent includes：
0.1-0.2 parts of dodecyl benzyl dimethyl ammonium chloride；
0.5-0.8 parts of polyaminopropyl biguanide；
The thickener includes：
0.5-3 parts of Acritamer 940；
The emulsifier includes：
Match 0.5-1 parts of Bick SIMULGEL INS 100.
Preferably,
The plant extracts further includes：
1-5 parts of grape seed extract；
1-8 parts of apple pomace extract；
1-10 parts of mango pomace extract.
Preferably,
The plant extracts further includes：
1-3 parts of grape seed extract；
1-5 parts of apple pomace extract；
2-7 parts of mango pomace extract.
To facilitate the understanding of the present invention, the technical solution further illustrated the present invention with reference to embodiment.Applicant
Statement, the present invention illustrate detailed process equipment and the technological process of the present invention, but the present invention not office by above-described embodiment
It is limited to above-mentioned detailed process equipment and technological process, that is, does not mean that the present invention has to rely on above-mentioned detailed process equipment and technique
Flow could be implemented.Person of ordinary skill in the field is each to product of the present invention it will be clearly understood that any improvement in the present invention
The equivalence replacement of raw material and the addition of auxiliary element, the selection of concrete mode etc. all fall within protection scope of the present invention and openly
Within the scope of.
1 embodiment 1-5 each component parts by weight tables of table
The preparation method of the antibacterial blemish clearing gel of multiple target point in embodiment 1-5：
S1 configures the pre-dispersed solution of thickener based on glycerine and thickener；
S2, take be equivalent to solid inventory as 1 medium multiple of table purified water 70%, be placed in container and stir and heat up
To temperature in such as table 1, cool down after the pre-dispersed solution mixing of the thickener is added；
Monomeric compound, plant extracts, whitening agent, moisturizing renovation agent, penetration enhancers, bacteriostatic agent, thickening is added in S3
Agent and emulsifier, mixing；
The purified water of surplus is added in S4, is stood to get to the antibacterial blemish clearing gel of the multiple target point after mixing.
Embodiment 1：
The present embodiment provides a kind of antibacterial blemish clearing gels of multiple target point, including following ingredient：Monomeric compound, plant extract
Object, whitening agent, moisturizing renovation agent, penetration enhancers, bacteriostatic agent, thickener and emulsifier, Yi Jishui.
Based on above-mentioned preparation method, the antibacterial blemish clearing gel of multiple target point in the present embodiment, specific each component parts by weight are prepared
Number is shown in Table 1.
Embodiment 2：
The present embodiment provides a kind of antibacterial blemish clearing gels of multiple target point, including following ingredient：Monomeric compound, plant extract
Object, whitening agent, moisturizing renovation agent, penetration enhancers, bacteriostatic agent, thickener and emulsifier, Yi Jishui.
Based on above-mentioned preparation method, the antibacterial blemish clearing gel of multiple target point in the present embodiment, specific each component parts by weight are prepared
Number is shown in Table 1.
Embodiment 3：
The present embodiment provides a kind of antibacterial blemish clearing gels of multiple target point, including following ingredient：Monomeric compound, plant extract
Object, whitening agent, moisturizing renovation agent, penetration enhancers, bacteriostatic agent, thickener and emulsifier, Yi Jishui.
Based on above-mentioned preparation method, the antibacterial blemish clearing gel of multiple target point in the present embodiment, specific each component parts by weight are prepared
Number is shown in Table 1.
Embodiment 4：
The present embodiment provides a kind of antibacterial blemish clearing gels of multiple target point, including following ingredient：Monomeric compound, plant extract
Object, whitening agent, moisturizing renovation agent, penetration enhancers, bacteriostatic agent, thickener and emulsifier, Yi Jishui.
Based on above-mentioned preparation method, the antibacterial blemish clearing gel of multiple target point in the present embodiment, specific each component parts by weight are prepared
Number is shown in Table 1.
Embodiment 5：
The present embodiment provides a kind of antibacterial blemish clearing gels of multiple target point, including following ingredient：Monomeric compound, plant extract
Object, whitening agent, moisturizing renovation agent, penetration enhancers, bacteriostatic agent, thickener and emulsifier, Yi Jishui.
Based on above-mentioned preparation method, the antibacterial blemish clearing gel of multiple target point in the present embodiment, specific each component parts by weight are prepared
Number is shown in Table 1.
Results and discussion：
1, experimental method：
The present invention has carried out bacteriostatic experiment and anti-inflammatory respectively for the antibacterial blemish clearing gel of multiple target point prepared in embodiment 1-5
Active contrast experiment, the specific method is as follows：
(1) bacteriostatic activity test：
This experiment is measured the bacteriostatic activity of the antibacterial blemish clearing gel of multiple target point prepared in embodiment 1-5.
The filter paper for selecting water absorbing force strong and homogeneous, the circle scraps of paper of 6mm diameters, 120 DEG C of dryings are made of perforator
Sterilizing 2 hours.Every 20 scraps of paper, which are added in the blemish clearing gel for diluting ten times, (to be taken 1g blemish clearing gels to be sufficiently stirred to be distributed to 9g and go out
In bacterium pure water), make scraps of paper homogeneous immersion, be placed in sterilized petri dishes, sets drying in 37 DEG C of baking ovens, dispense in bottle, sealing, 4
DEG C preserve, it is spare.
Dilution bacterium solution (staphylococcus aureus, the epidermis grape ball of several Fresh in being dipped respectively with sterile swab stick
Bacterium, propionibacterium acnes (P.acnes) and Malassezia furfur (M.furfur)), extra bacterium solution is gone in being squeezed on tube wall, is uniformly applied
It is distributed on NA plating mediums, sweeps a circle in plate edge ring, cover, dry 2-3min.Above-mentioned dry drug containing filter is taken with tweezers
The scraps of paper are affixed on plate center.Each type strain do three groups it is parallel, inhibition zone takes its average value.The above operation is in bio-safety
It is carried out in cabinet.
Propionibacterium acnes (P.acnes) 37 DEG C of constant-temperatureanaerobic anaerobic culture 72h, 37 DEG C of constant temperature incubation 18h of staphylococcus,
30 DEG C of constant temperature incubation 48h of M.furfur.The size of each inhibition zone of Observe and measure.
Positive reference substance selects commercially available Chinese medicine compound prescription Whelk-eliminating paste A, is handled with same scheme.
(2) anti-inflammatory activity is tested：
This experiment is measured the anti-inflammatory activity of the antibacterial blemish clearing gel of multiple target point prepared in embodiment 1-5.
Take mice ear acute model experiment test.
Experiment packet：
Divide 8 groups by kunming mouse；
Blank group 10 does not apply with any preparation；
Every group each 10 of dimethylbenzene group (model group) and positive controls (the common Chinese medicine compound acne-removing cream A of market purchase)
Only；
Embodiment 1-5 groups, every group each 10.
The mouse right ear exterior feature upper and lower surface other than blank group of erasing is applied with 20 μ L dimethylbenzene respectively, it is swollen that acute ear is established in induction
It is swollen, retain 30min.
Blank group and model group are taken, takes mouse auricle to weigh with 9mm card punch, takes its average value.
Then it is smeared with the antibacterial blemish clearing gel of the multiple target point prepared in embodiment 1-5 and commercially available Chinese medicine compound prescription Whelk-eliminating paste A surplus
Remaining mouse ear two sides retains 30min, takes auricle to weigh, be averaged and compared.
(3) patient's using effect is investigated：
Data survey statistical method：
The implementation result of acne treatment, collect 35 patients with acne, the age between -28 years old 15 years old, 25 people of male, female
Property 15 people, it is respectively 8 people and 20 people that acne symptom, which is assessed as I and II type symptoms person, III type symptom, 7 people, without IV type Cuo
Sore patient.
After patients with acne twice daily washes one's face, in acne spots and the corresponding sterile products blemish clearing gel of periphery spot printing, make
After one month, the method evaluated using patient's self-appraisal and dermatologist is judged the validity of the blemish clearing gel, is divided into significantly
Effective, effective, general and completely ineffective four ratings of property.
2, experimental result：
(1) bacteriostatic activity test：
(it is more than 20mm for Gao Min, 20-10mm is sensitivity, is less than 10mm with reference to the sensibility evaluation criteria of antibacterials
Drug resistance), as shown in Table 2, staphylococcus aureus, staphylococcus epidermis are dispelled for the multiple target point prepared by embodiment 1-5 is antibacterial
Acne gel is Gao Min, and M.furfur, P.acnes are sensitivity.
And commercially available Chinese medicine compound prescription Whelk-eliminating paste A, sensitivity is only belonged to staphylococcus, and be to M.furfur, P.acnes
Drug resistance.
To sum up, it was demonstrated that the antibacterial blemish clearing gel of multiple target point prepared by embodiment 1-5 is with commercially available Chinese medicine compound prescription Whelk-eliminating paste A right
Causing has better fungistatic effect on the pattern microorganism of acne.
2 embodiment 1-5 inhibition zone datas table (mm) of table
(2) anti-inflammatory activity is tested：
As shown in Table 3, dimethylbenzene group (model group) can significantly cause mouse ear to generate acute inflammation and swelling, it was demonstrated that modeling
Success.
The antibacterial blemish clearing gel of multiple target point and positive controls prepared by embodiment 1-5 are applied to the mouse ear for generating swelling
Guo Shangke effectively reduces its inflammatory reaction, and the antibacterial blemish clearing gel of multiple target point of embodiment 1-5 and positive controls (commercially available Chinese medicine
Compound acne-removing cream A) compared to having significant difference, illustrate the antibacterial anti-acne of multiple target point of the embodiment 1-5 on reducing inflammatory reaction
Gel outclass commercially available Chinese medicine compound prescription Whelk-eliminating paste A.
3 embodiment 1-5 anti-inflammatory activity experiment mice auricles of table weightening comparison (%)
(3) patient's using effect is investigated：
It referring to table 4, is found by statistics, which than more significant, is evaluated as the therapeutic effect of acne
Effectively others is respectively 85.8% and 8.6% to conspicuousness with effective two grades, and total effective rate reaches 94.4%, this and the disinfection
Product, which is treated and paid close attention in Compound Chinese Herbal Monomer Recipe multiple target point, reduces patient skin inflammation, and enhancing skin barrier caused by acne is impaired
There is direct relation.
Relevant comparative's photo of related patients with acne treatment, refers to picture 1-3.
4 patient's using effect investigation statistics table of table
Experimental result is summarized：
It is found by comparing, the antibacterial blemish clearing gel of multiple target point that embodiment 1-5 is provided shows stronger antibacterial work
Property and anti-inflammatory activity, especially embodiment 5 in sample, sensitive and Gao Min is reached to the bacteriostatic activity of acne pattern microorganism
State, anti-inflammatory activity is notable, compared with commercially available Chinese medicine compound prescription Whelk-eliminating paste A, shows strong biocidal property and anti-inflammatory activity.
Claims (10)
1. a kind of preparation method of the antibacterial blemish clearing gel of multiple target point, which is characterized in that including：
Configure the pre-dispersed solution of thickener；
70% purified water of said preset amount of water is added in container, is stirred and heated to 80-90 DEG C, the thickener is added and divides in advance
It dissipates solution and carries out homogeneous, obtain homogenizing fluid；
The homogenizing fluid is cooled down, reaches 40-50 DEG C, obtains half coolant liquid；
After multiple target point functional drug and emulsifier are pre-mixed, it is added in half coolant liquid, is emulsified after stirring
Liquid；The multiple target point functional drug includes soluble compounds and insoluble compound；The multiple target point functional drug includes
Soluble substance and insoluble material；
In the emulsion be added essence and the said preset amount of water 30% purified water, after stirring stand solidification to get to
The antibacterial blemish clearing gel of multiple target point.
2. the preparation method of the antibacterial blemish clearing gel of multiple target point as described in claim 1, which is characterized in that
The soluble compounds include jamaicin, paeonol；The insoluble compound includes Cineole and eugenol；
The multiple target point functional drug further includes：Plant extracts, whitening agent, moisturizing renovation agent and bacteriostatic agent；
The soluble compounds include jamaicin, paeonol；The insoluble compound includes Cineole and eugenol；
The plant extracts includes licorice and Gotu Kola P.E；
The whitening agent includes niacinamide and Victoria C ethylether；
The moisturizing renovation agent includes ceramide, phytosphingosine and allantoin；
The bacteriostatic agent includes dodecyl benzyl dimethyl ammonium chloride and polyaminopropyl biguanide.
3. the preparation method of the antibacterial blemish clearing gel of multiple target point as claimed in claim 2, which is characterized in that the plant extracts is also
Including grape seed extract, apple pomace extract and mango pomace extract.
4. the preparation method of the antibacterial blemish clearing gel of multiple target point as claimed in claim 3, which is characterized in that
The emulsifier is match Bick；It is described " after being pre-mixed multiple target point functional drug and emulsifier, to be added described half
In coolant liquid, emulsion is obtained after stirring " include：
Cineole and eugenol are taken, is mixed with emulsifier, oiliness emulsion is obtained；Also,
Be reduced incremental method by jamaicin, paeonol, niacinamide, Victoria C ethylether, ceramide, phytosphingosine, allantoin,
Dodecyl benzyl dimethyl ammonium chloride, polyaminopropyl biguanide are mixed, and medicinal mixture is obtained；
Oiliness emulsion, medicinal mixture, licorice, product is added to be incremented by principle by amount successively into half coolant liquid
The careless extract of snow, grape seed extract, apple pomace extract and mango pomace extract, and be stirred, obtain breast
Change liquid.
5. the preparation method of the antibacterial blemish clearing gel of multiple target point as claimed in claim 3, which is characterized in that described " by multiple target point work(
After energy property drug and emulsifier are pre-mixed, it is added in half coolant liquid, emulsion is obtained after stirring " before, further include：
Extracting liquorice and centella crush respectively, obtain Radix Glycyrrhizae extraction raw material and centella extraction raw material；Also, by grape
Seed, apple pomace and mango pomace are dried；
Radix Glycyrrhizae extraction raw material is extracted using microwave alcohol extracting method, obtains the licorice；Utilize macroporous absorption
Resins extraction method extracts centella extraction raw material, obtains the Gotu Kola P.E；Utilize high speed adverse current chromatogram
Method extracts grape pip, apple pomace and mango pomace respectively, obtains grape seed extract, apple pomace extract and awns
Fruit pomace extract.
6. the preparation method of the antibacterial blemish clearing gel of multiple target point as claimed in claim 5, which is characterized in that
" being extracted to Radix Glycyrrhizae extraction raw material using microwave alcohol extracting method, obtain the licorice " includes：
Extracting liquorice extracts raw material, after being impregnated with 60% ethyl alcohol, by Microwave Extraction 3 times, 1 hour every time, merges Microwave Extraction liquid,
The licorice is obtained after concentration；
It is described " centella extraction raw material to be extracted using macroporous absorbent resin extraction method, the centella is obtained and carries
Take object " include：
After taking the centella raw material to be extracted by 70% ethyl alcohol, centella ethanol extract is obtained, then by the centella second
Alcohol extracting thing is purified by macroporous absorbent resin, and mobile phase is 70% ethyl alcohol, is eluted defensive position machine eluate and is concentrated,
Obtain the licorice.
7. the preparation method of the antibacterial blemish clearing gel of multiple target point as claimed in claim 5, which is characterized in that
It is described " grape pip, apple pomace and mango pomace to be extracted respectively using supercritical extract, obtain grape pip extraction
Object, apple pomace extract and mango pomace extract " include：
The ethyl alcohol that grape pip, apple pomace and mango pomace are separately added into 60-70% is taken to be impregnated, extraction is carried to obtain ethyl alcohol
Object is taken, and is extracted 3 times by high speed adverse current chromatogram hair, merges extracting solution, grape seed extract, apple is respectively obtained after concentration
Fruit pomace extract and mango pomace extract.
8. the preparation method of the antibacterial blemish clearing gel of multiple target point as described in claim 1, which is characterized in that
It is described " after being pre-mixed multiple target point functional drug and emulsifier, to be added in half coolant liquid, obtained after stirring
In emulsion ", the mixing time being added after multiple target point functional drug and emulsifier is 25-35 minutes；
It is described " 30% purified water of essence and the said preset amount of water to be added in the emulsion, solidification is stood after stirring, i.e.,
Obtain the antibacterial blemish clearing gel of the multiple target point " in, the pure of the 30% of essence and the said preset amount of water is added in the emulsion
Change water and the mixing time being stirred is 5-15 minutes.
9. the preparation method of the antibacterial blemish clearing gel of multiple target point as described in claim 1, which is characterized in that " the configuration thickener
Pre-dispersed solution " includes：
10-20 parts of glycerine are taken to be mixed with 15-30 parts of thickener, homogeneous is stirred until homogeneous dispersion, and mixing time is 25-35 points
Clock is to get to the pre-dispersed solution of the thickener；
The thickener is Acritamer 940.
10. the preparation method of the antibacterial blemish clearing gel of multiple target point as described in claim 1, which is characterized in that
Said preset amount of water is 5-10 times of multiple target point functional drug and emulsifier total weight.
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