CN111358719B - Chinese herbal medicine lipstick with cheilitis prevention function and preparation method thereof - Google Patents
Chinese herbal medicine lipstick with cheilitis prevention function and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine lipstick with a cheilitis prevention function, which is prepared from the following raw materials in parts by weight: astragalus water extract, astragalus diethyl ether extract, codonopsis pilosula water extract, codonopsis pilosula diethyl ether extract, peach kernel extract, beeswax, edible toner, hyaluronic acid, jasmine wax, tea polyphenol, olive oil, refined chicken oil, vitamin C, diisostearyl malate, food-grade vaseline and modified attapulgite; and a preparation method thereof are provided. The beneficial effects of the invention are as follows: the Chinese herbal medicine lipstick with the function of preventing cheilitis and the preparation method thereof can solve the problem of cheilitis high incidence in northwest or northeast and other dry areas and provide a milder product for people using common lipstick. The product has the effects of preventing cheilitis, treating cheilitis, nourishing lips, moisturizing, resisting bacteria and the like, and also has the advantages of positive color, durability, easiness in production and the like.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine cosmetics, in particular to a Chinese herbal medicine lipstick with a cheilitis prevention function and a preparation method thereof.
Background
The application of Chinese herbal medicine in cosmetics is very wide, the Chinese herbal medicine beauty is the perfect combination of traditional Chinese medicine and personal care products, and the Chinese herbal medicine beauty is not only a plant from the east, but also has the support of the Chinese medicine theory. The concept of Chinese herbal medicine is accepted in China and even Asia, and developed countries in Europe and America begin to pay attention to the application of traditional Chinese herbal medicine in cosmetics. The traditional Chinese medicine is profound and rich in resources, and the Chinese herbal medicine becomes the focus of research and development of the global beauty skin care product. The development trend of the world cosmetics is advocated to be green, environment-friendly and safe and pursue efficacy, so that the traditional Chinese herbal medicine extract with mild effect and certain efficacy is used as a natural product additive in the cosmetics in recent decades, and the traditional Chinese herbal medicine extract is applied to the cosmetics to become a hot spot for developing new products, and the cosmetics quickly surge into the cosmetic market and are gradually recognized and accepted by consumers. However, the Chinese herbal medicine cosmetics are mainly concentrated on the skin care products, have the effects of removing dirt and cleaning, nourishing and moisturizing, whitening, moisturizing, anti-inflammatory and anti-aging, and basically cover all kinds of skin care products, such as facial cleanser, essence, facial mask, cream and the like.
Chinese is the origin of Chinese herbal medicines, and the quantity of Chinese herbal medicines is not possessed by other countries, so that the Chinese herbal medicines are also the congenital advantages of Chinese herbal medicine cosmetic brand development. In the latest edition of the catalogue of names of raw materials of cosmetics which have been used issued by 6 month 2015, 2499 Chinese herbal medicine raw materials exist among 8783 raw materials of cosmetics which can be used in the Chinese market. It is known that the traditional Chinese medicines used in various places in China at present are 5000 kinds, and the prescription formed by combining various medicinal materials is rather countless.
From the historical perspective, the Chinese ancient Chinese advanced Chinese herbal medicines and Chinese medicines are deeply explored, researched and summarized as well as the Chinese medicines for treating diseases, so that the Chinese herbal medicines are most widely accepted and applied. Wherein, the application history of traditional Chinese medicine in the aspect of beauty and skin care is very long. The addition of Chinese herbal medicines to cosmetics has been a lineage for thousands of years. From the consumer perspective, china consumers have seen tremendous changes with economic development and consumer upgrades. The Chinese herbal medicine is a precious resource in China, is a bright pearl which cannot be ignored in the history of Chinese civilization, and Chinese consumers have a sense of relativity and trust in the nature. If Chinese cosmetic enterprises can continuously strengthen the scientific research investment of Chinese herbal medicine cosmetics, the Chinese herbal medicine cosmetics are superior to chemical cosmetics in aspects of efficacy, quality, safety and the like, and the Chinese herbal medicine cosmetics are expected to be more easily obtained to be affirmative and loved by a wide consumer group.
However, the inventor of the patent finds that the Chinese herbal medicine is mainly used in skin care products at present through market research and inquiry documents, and rarely interferes with a large part of makeup in cosmetics, and the commercial Chinese herbal medicine makeup is hardly inquired, and only a small amount of Chinese herbal medicine lipstick is available in document retrieval, so that the application of Chinese herbal medicine in the preparation of other makeup is not seen.
Chinese patent CN107625681a discloses a moisturizing lipstick added with Chinese herbal medicines, which is prepared from the following components in parts by weight: 2-4 parts of peach blossom extract, 1-3 parts of orange blossom extract, 2-4 parts of ginkgo extract, 1-3 parts of cactus extract, 1-3 parts of rose alcohol, 3-5 parts of rose root, 3-5 parts of astragalus root, 4-6 parts of prepared rehmannia root, 2-3 parts of white caustic, 0.3-0.5 part of vitamin E, 2-4 parts of butter, 1-3 parts of lavender oil, 3-7 parts of natural pigment, 1-3 parts of olive wax, 0.8-1 part of beeswax and 15-25 parts of deionized water. The lipstick of the invention adopts natural plant extract juice and mulberry very extract juice as pigment dyes, other components do not contain any artificially synthesized compounds, and the natural plant wax, the vegetable oil, the plant spice and the Chinese herbal medicine are all taken, so that the lipstick is nontoxic to human body, can lubricate the mucous membrane of the lips, does not generate anaphylactic reaction, promotes blood circulation and promotes body health. Although a large amount of Chinese herbal medicine components are used in the lipstick, the effect of the lipstick after the Chinese herbal medicine is specifically used is not taught, and the lipstick has the effect equivalent to the effect of the lipstick sold at present and does not show the special effect after the Chinese herbal medicine is added.
Chinese patent CN201810909693.4 provides a Chinese herbal medicine lipstick for improving the medicinal effect and a preparation method thereof, and relates to the technical field of cosmetics. The preparation method comprises the following steps: s1, drying fresh Chinese herbal medicine plants, grinding the fresh Chinese herbal medicine plants into powder, and adding the powder into an organic solvent to obtain a mixed solution. S2, carrying out ultrasonic treatment on the mixed solution for 6-16 min, then carrying out water bath or oil bath for 10-30 min at the temperature of 40-80 ℃, and centrifuging to obtain supernatant. S3, removing the organic solvent in the supernatant, adding sweet almond oil, dissolving for 12-24 hours, and filtering to obtain the mixed oil containing the medicinal components of the Chinese herbal medicines. S4, preparing the Chinese herbal medicine lipstick from 5-10 parts by weight of mixed oil, 1-3 parts by weight of vegetable wax and 0.1-0.5 part by weight of vitamin E. The Chinese herbal medicine lipstick adopts purely natural Chinese herbal medicine plants as raw materials, has simple components and high Chinese herbal medicine effect content, and is beneficial to maintenance of lips. The preparation method is simple, the conditions are easy to control, and the operation is easy. Also, the invention does not describe the special efficacy of the contained herbal ingredients on lips.
Chinese patent CN201710187284.3 relates to a Chinese herbal lipstick for preventing and/or treating chronic cheilitis, which is prepared by the following method: (1) Taking 1.5 parts of beeswax and 2.0 parts of Vaseline, and heating and melting in a water bath to obtain a mixed solution 1; (2) Taking 1.0 part of lanolin and 5.0 parts of traditional Chinese medicine extract, and heating and melting in a water bath to obtain a mixed solution 2; (3) Mixing the mixed solution 1 and the mixed solution 2, adding 0.5 part of azone, uniformly mixing, placing at 50-60 ℃, adding peppermint essential oil, mixing and canning. The invention combines traditional Chinese medicine with daily skin care products, combines theories and practice, derives and pushes out novel Chinese herbal medicine lipstick with treatment effect, and the lipstick has the advantages of simple preparation process, easily obtained raw materials, low cost, obvious effect on chronic cheilitis, difficult recurrence after healing and higher market popularization and application value. The invention uses lithospermum, madder and licorice, which have certain effect on treating cheilitis, but no other functions are mentioned.
Chinese patent CN201610329818.7 discloses a lipstick containing Chinese herbal medicine extract, which is prepared from 10-20 parts of candelilla wax, 10-20 parts of rose wax, 25-45 parts of olive oil, 20-30 parts of sweet almond oil, 15-30 parts of rose fruit oil, 6-10 parts of malus asiatica, 1-5 parts of geranium essential oil, 3-8 parts of barbed skullcap herb extract and 2-6 parts of chrysanthemum extract, and has the effect of treating lip skin sensitivity. The lipstick of the invention adopts pure natural substances, is safe and non-irritating, and has the efficacy of treating sensitive lip skin after long-term use.
It can be seen from the above reported documents that the application of the Chinese herbal medicine to lipstick or lipstick is possible, but the prevention and treatment of cheilitis is still not good.
Disclosure of Invention
The invention aims at overcoming the defects in the prior art, and provides a Chinese herbal medicine lipstick with a cheilitis prevention function and a preparation method thereof.
In order to achieve the above purpose, the technical scheme provided by the invention is as follows: a Chinese herbal medicine lipstick with a cheilitis prevention function is prepared from the following raw materials in parts by weight: 18 parts of astragalus root water extract, 5 parts of astragalus root diethyl ether extract, 5 parts of codonopsis pilosula water extract, 2 parts of codonopsis pilosula diethyl ether extract, 15 parts of peach kernel extract, 21 parts of beeswax, 1 part of edible toner, 4 parts of hyaluronic acid, 5 parts of jasmine flower wax, 1 part of tea polyphenol, 8 parts of olive oil, 4 parts of refined chicken oil, 1 part of vitamin C, 1 part of diisostearyl malate, 7 parts of food-grade vaseline and 2 parts of modified attapulgite.
Furthermore, the Chinese herbal medicine lipstick with the cheilitis preventing function, wherein the astragalus water extract is water-soluble extract powder, and the preparation method comprises the following steps: cleaning astragalus, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding ultrapure water with the mass of 20 times of the astragalus, stirring for 30 minutes at a low temperature and with the ultrasonic power of 60kHz at the temperature of 20 ℃ at the stirring speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the high-temperature high-pressure difference continuous cell wall crushing conditions are as follows: concentrating the water solution at 15 deg.C under 300MPa at 3L/h flow rate to water content not higher than 10%, freeze drying at-25deg.C for 48 hr, and pulverizing to 1500 mesh to obtain radix astragali water-soluble extract powder.
Further, the Chinese herbal medicine lipstick with the cheilitis preventing function, wherein the astragalus root diethyl ether extract is diethyl ether extract powder, and the preparation method comprises the following steps: cleaning astragalus, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding anhydrous diethyl ether with the mass of 10 times, stirring for 30 minutes at a low temperature and ultrasonic power of 60kHz at the temperature of 20 ℃, and stirring at the speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the high-temperature high-pressure difference continuous cell wall crushing conditions are as follows: distilling at 15 deg.C under 300MPa at 3L/h flow rate under reduced pressure to remove diethyl ether completely, distilling at 50 deg.C under-0.1 MPa, and pulverizing to 1500 mesh to obtain radix astragali organic solvent extract powder.
Furthermore, the Chinese herbal medicine lipstick with the cheilitis prevention function, wherein the radix codonopsis water extract is water-soluble extract powder, and the preparation method comprises the following steps: cleaning radix codonopsis pilosulae, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding ultrapure water with the mass of 20 times of the radix codonopsis pilosulae, stirring at a low temperature for 30 minutes under the condition of 20 ℃ and the ultrasonic power of 60kHz at the stirring speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the crushing conditions of the high-temperature high-pressure difference continuous cell wall are as follows: concentrating the water solution at 15 deg.C under 300MPa at 3L/h flow rate to water content not higher than 10%, freeze drying at-25deg.C for 48 hr, and pulverizing to 1500 mesh to obtain radix Codonopsis water-soluble extract powder.
Further, the Chinese herbal medicine lipstick with the cheilitis prevention function, wherein the codonopsis pilosula diethyl ether extract is diethyl ether extract powder, and the preparation method comprises the following steps: cleaning radix codonopsis pilosulae, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding anhydrous diethyl ether with the mass of 10 times, stirring for 30 minutes at a low temperature and with the ultrasonic power of 60kHz at the temperature of 20 ℃, and stirring at the speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the high-temperature high-pressure difference continuous cell wall crushing conditions are as follows: distilling at 15 deg.C under 300MPa at 3L/h flow rate under reduced pressure to remove diethyl ether completely, distilling at 50 deg.C under-0.1 MPa, and pulverizing to 1500 mesh to obtain radix Codonopsis organic solvent extract powder.
Further, the preparation method of the Chinese herbal medicine lipstick with the cheilitis prevention function comprises the following steps of: cleaning peach kernels, drying, superfine grinding to 800 meshes, wherein the drying temperature is 85 ℃ for 24 hours, adding a mixed solvent with the mass of 20 times of that of the peach kernels, mixing the mixed solvent with ultrapure water with the volume ratio of 20% of ethanol to 80%, stirring the mixed solvent with ultrasonic at a low temperature for 30 minutes, wherein the temperature is 20 ℃, the ultrasonic power is 60kHz, the stirring speed is 200r/min, extracting organic solvent soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, and the low-temperature high-pressure difference continuous cell wall crushing conditions are as follows: freeze drying at 15 deg.C under 300MPa at 3L/h flow rate to remove solvent, freezing at-25 deg.C, drying for 48 hr, and pulverizing to 1500 mesh to obtain semen Persicae extract powder.
Further, the preparation method of the modified attapulgite is as follows: preparing commercial sweet almond oil into an anhydrous diethyl ether solution with the mass concentration of 5% according to the condition that the solute is sweet almond oil and the solvent is anhydrous diethyl ether, dripping concentrated sulfuric acid with the mass of two parts per million of the sweet almond oil, stirring while dripping, then adding attapulgite powder with the mass of 20 times of the sweet almond oil, stirring at 60 ℃ for reflux reaction, and removing generated water while stirring until no water is generated; and (3) carrying out filter pressing on the obtained anhydrous product, wherein the filter pressing pressure is 0.159Mpa, adopting a microporous filter membrane with the diameter of 0.45 mu m, washing for 3-5 times by using ultrapure water, and carrying out spray drying at the temperature of 120 ℃ and the concentration of 10mL/min to ensure that the water content is not higher than 0.2%, thereby obtaining the modified attapulgite with the particle size of more than or equal to 3000 meshes.
Further, the preparation method of the refined chicken oil comprises the following steps of: collecting chicken oil in a freshly slaughtered hen, placing in an oil bath pan under nitrogen protection, heating and stirring at 120 ℃, and removing water by an oil-water separator while heating until no water is separated out to obtain refined chicken oil.
The second object of the present invention is to provide a preparation method of the Chinese herbal medicine lipstick with the function of preventing cheilitis, which comprises the following steps:
1) Blending the modified attapulgite with edible toner in a proportion, and ball-milling for 15min at 1400r/min to obtain a raw material S1;
2) Blending the refined chicken oil with the peach kernel extract in a proportion, performing ball milling for 25min at 1400r/min to obtain a raw material S2;
3) Mixing the astragalus water extract, the astragalus diethyl ether extract, the radix codonopsis water extract, the radix codonopsis diethyl ether extract, the tea polyphenol and the vitamin C according to the proportion, and ball milling for 10min at 1000r/min to obtain a raw material S3;
4) Mixing beeswax, jasmine wax and food-grade vaseline in a proportion, heating to 80 ℃ under the protection of 99.99% high-purity nitrogen gas for melting, and fully and uniformly stirring to obtain a raw material S4;
5) Uniformly mixing the hyaluronic acid, the olive oil and the diisostearyl alcohol malate in a ratio to obtain a raw material S5;
6) And (3) uniformly mixing the raw materials S1, S2, S3, S4 and S5 obtained in the steps 1) to 5), injecting the mixed materials into a mold, cooling to 8 ℃, demolding, shaping and boxing to obtain the Chinese herbal medicine lipstick with the cheilitis prevention function.
The technical innovation points of the invention mainly comprise the following points:
1. the sweet almond oil is skillfully grafted on the surface of the attapulgite, so that inorganic attapulgite can better load and disperse edible toner, and the compatibility between the attapulgite and other organic matters is better;
2. nutritional astragalus and codonopsis pilosula are firstly introduced into lipstick, so that the lipstick has the effects of resisting bacteria, diminishing inflammation and nourishing;
3. the peach kernel extract and chicken oil are introduced into the lipstick for the first time, so that the lipstick has better effect of preventing and treating cheilitis;
4. the product has the effects of preventing cheilitis, treating cheilitis, nourishing lips, moisturizing, resisting bacteria and the like, and is a real multifunctional Chinese herbal medicine lipstick.
The beneficial effects of the invention are as follows: the Chinese herbal medicine lipstick with the function of preventing cheilitis and the preparation method thereof can solve the problem of cheilitis high incidence in northwest or northeast and other dry areas and provide a milder product for people using common lipstick. The product has the effects of preventing cheilitis, treating cheilitis, nourishing lips, moisturizing, resisting bacteria and the like, and also has the advantages of positive color, durability, easiness in production and the like.
Detailed Description
The source of the preparation used in the invention is as follows:
sweet almond oil: jiangxi kaleidoscopic fragrance Co., ltd., 8007-69-0.
Attapulgite powder: xuyi European Baite clay materials Co., ltd., OBT-A-2.
Edible toner: guangzhou diamond color cosmetics, inc., U.S. solar toner, C19-012.
Hyaluronic acid: western Anwanfang Biotechnology Co., ltd., product number: 2019-5-TMZS.
Jasmine flower wax: cangzhou Cheng Shila, inc., 19.
Tea polyphenols: shanghai Miclin Biochemical technologies Co., ltd., product number: t821916-100g.
Olive oil: la Tourangelle, LAT-00570.
Vitamin C: zhengzhou Zhengzhu biotechnology limited, DB-VC.
Diisostearyl alcohol malate: shanghai Ding chemical industry trade Limited company, 019.
Food-grade vaseline: shandong Han Linjun International trade company, goods number: HLJ-50-FSL.
Example 1:
a Chinese herbal medicine lipstick with a cheilitis prevention function is prepared from the following raw materials in parts by weight: 18kg of astragalus water extract, 5kg of astragalus diethyl ether extract, 5kg of codonopsis pilosula water extract, 2kg of codonopsis pilosula diethyl ether extract, 15kg of peach kernel extract, 21kg of beeswax, 1kg of edible toner, 4kg of hyaluronic acid, 5kg of jasmine flower wax, 1kg of tea polyphenol, 8kg of olive oil, 4kg of refined chicken oil, 1kg of vitamin C, 1kg of diisostearyl malate, 7kg of food-grade vaseline and 2kg of modified attapulgite.
Wherein, the astragalus water extract is water-soluble extract powder, and the preparation method thereof comprises the following steps: cleaning radix astragali, slicing (thickness of 2 mm), drying, superfine pulverizing to 800 mesh (drying at 85deg.C for 24 hr), adding ultrapure water 20 times the mass of the powder, stirring at low temperature for 30min (at 20deg.C and ultrasonic power of 60kHz and stirring speed of 200 r/min), extracting water-soluble essence component (15 deg.C, 300Mpa,3L/h flow) by low-temperature high-pressure difference continuous cell wall crushing extraction technology, concentrating the aqueous solution, lyophilizing (concentrating to water content not higher than 10%, -25deg.C, drying for 48 hr), and pulverizing to 1500 mesh to obtain radix astragali water-soluble extract powder.
Wherein the astragalus root diethyl ether extract is diethyl ether extract powder, and the preparation method comprises the following steps: cleaning radix astragali, slicing (above), drying, superfine pulverizing to 800 mesh (above), adding 10 times of anhydrous diethyl ether, stirring at low temperature under ultrasound for 30min (above), extracting organic solvent soluble essence component (above) by low temperature and high pressure difference continuous cell wall crushing extraction technique, vacuum distilling to completely remove diethyl ether (under reduced pressure distillation condition of 50 deg.C, -0.1 MPa), and pulverizing to 1500 mesh to obtain radix astragali organic solvent extract powder.
Wherein the radix codonopsis water extract is water-soluble extract powder, and the preparation method comprises the following steps: cleaning radix Codonopsis, slicing (same as above), drying, superfine pulverizing to 800 mesh (same as above), adding ultrapure water 20 times the mass of the powder, stirring at low temperature and under ultrasound for 30min (same as above), extracting water-soluble essence component (same as above) by using low-temperature high-pressure difference continuous cell wall crushing extraction technology, concentrating aqueous solution, lyophilizing (same as above), and pulverizing to 1500 mesh to obtain radix Codonopsis water-soluble extract powder.
Wherein the radix codonopsis diethyl ether extract is diethyl ether extract powder, and the preparation method comprises the following steps: cleaning radix Codonopsis, slicing (above), drying, superfine pulverizing to 800 mesh, adding 10 times of anhydrous diethyl ether, stirring at low temperature under ultrasound for 30min (above), extracting organic solvent soluble essence component (above) by low temperature and high pressure difference continuous cell wall crushing extraction technique, vacuum distilling to completely remove diethyl ether, and pulverizing to 1500 mesh to obtain radix Codonopsis diethyl ether extract powder.
The preparation method of the peach kernel extract comprises the following steps: cleaning semen Persicae, drying, superfine pulverizing to 800 mesh (above), adding 20 times of mixed solvent, mixing with 20% ethanol and 80% ultrapure water, stirring at low temperature and high pressure for 30min (above), extracting organic solvent soluble essence component (above) by low temperature and high pressure difference continuous cell wall breaking extraction technique, lyophilizing to remove solvent (above), and pulverizing to 1500 mesh to obtain semen Persicae extract powder.
The preparation method of the modified attapulgite comprises the following steps: preparing commercial sweet almond oil into an anhydrous diethyl ether solution with the mass concentration of 5% (the solute is sweet almond oil and the solvent is anhydrous diethyl ether), dripping concentrated sulfuric acid with the mass of two parts per million of the sweet almond oil, stirring while dripping, then adding attapulgite powder with the mass of 20 times of the sweet almond oil, stirring at 60 ℃ for reflux reaction, and removing generated water while stirring until no water is generated; and (3) carrying out filter pressing (filter pressing under 0.159Mpa and a microporous filter membrane with the diameter of 0.45 mu m) on the obtained anhydrous product, washing with ultrapure water for 3-5 times, and carrying out spray drying (120 ℃ and 10 mL/min) to ensure that the water content is not higher than 0.2% and obtain the modified attapulgite with the particle size of more than or equal to 3000 meshes.
The preparation method of the refined chicken oil comprises the following steps: collecting chicken oil in a freshly slaughtered hen, placing in an oil bath, protecting with nitrogen, heating and stirring at 120deg.C, and removing water (oil-water separator in the device) while heating until no water is separated to obtain refined chicken oil.
The preparation method of the Chinese herbal medicine lipstick with the cheilitis prevention function comprises the following steps:
1) Blending the modified attapulgite with edible toner in a proportion, and ball milling (1400 r/min,15 min) to obtain a raw material S1; 2) Blending the refined chicken oil with the peach kernel extract in a proportion, and ball milling (1400 r/min,25 min) to obtain a raw material S2;
3) Mixing the astragalus water extract, the astragalus diethyl ether extract, the radix codonopsis water extract, the radix codonopsis diethyl ether extract, the tea polyphenol and the vitamin C according to the proportion, and performing ball milling (1000 r/min,10 min) to obtain a raw material S3;
4) Mixing beeswax, jasmine wax and food-grade vaseline in a certain proportion, heating under the protection of nitrogen to melt (80 ℃ and 99.99% of high-purity nitrogen), and fully and uniformly stirring to obtain a raw material S4;
5) Uniformly mixing the hyaluronic acid, the olive oil and the diisostearyl alcohol malate in a ratio to obtain a raw material S5;
6) And (3) uniformly mixing the raw materials S1, S2, S3, S4 and S5 obtained in the steps 1) to 5), injecting the mixed materials into a mold, cooling to 8 ℃, demolding, shaping and boxing to obtain the Chinese herbal medicine lipstick with the cheilitis prevention function.
Example 2:
the experimental effect test and characterization of the invention:
testing the product: the product of the invention; comparative 1 is a commercial big brand moisturizing lipstick; comparative 2 is consistent with the present invention, except that no two extracts of astragalus are contained; comparative 3 is consistent with the present invention, except that two extracts of codonopsis pilosula are absent; comparative example 4 was consistent with the present invention, except that the attapulgite was not modified; comparative 5 is consistent with the present invention except that S2 is absent; comparative 6 is consistent with the present invention except that it does not contain hyaluronic acid.
1. Test for cheilitis prevention:
students in school with history of cheilitis (100 last selected volunteers, women) were recruited on campus, and experience time was selected from 11 months in 2018 to 4 months in 2019, and ages 18-22 years. Volunteers were equally divided into 5 groups of 20 persons each, the first group using the product of the invention, the second group using comparative 1, the third group using comparative 2, the fourth group using comparative 3; the fifth group uses comparative 5. Volunteers know the mind in advance and voluntarily join the experience. Volunteers with severe cardiovascular, hepatic, renal and hematopoietic diseases, moderate or more diabetes, mental diseases, depression, etc.
The product was evenly applied to the lips before getting up in the morning and before class in noon, comparative 1, comparative 2, comparative 3 and comparative 5. The effect is tracked once a month. The effect was recorded by telephone return visit for the number of people not suffering from cheilitis, and finally the average value was calculated, and the values are shown in table 1.
TABLE 1
| Lipstick name | Month 1 | Month 2 | Month 3 | Month 4 | Month 5 | Month 6 |
| The invention is that | 100％ | 100％ | 95％ | 100％ | 100％ | 100％ |
| Comparative 1 | 100％ | 90％ | 75％ | 50％ | 40％ | 25％ |
| Comparative example 2 | 100％ | 100％ | 90％ | 75％ | 50％ | 60％ |
| Comparative example 3 | 100％ | 100％ | 95％ | 75％ | 80％ | 75％ |
| Comparative example 5 | 100％ | 100％ | 95％ | 95％ | 75％ | 60％ |
The invention shows that the astragalus, the dangshen and the peach kernel have very good synergistic effect of preventing cheilitis.
2. Treatment of cheilitis test:
chronic non-specific cheilitis patients (200 last selected volunteers, women) were selected from 2018, 11 months to 2019, 1 month in the collaborative hospital, and aged 28-45 years. Equally dividing the patients into 5 groups of 40 persons each, the first group using the product of the invention, the second group using comparison 1, the third group using comparison 2, the fourth group using comparison 3; the fifth group uses comparative 5. Patients were informed and voluntarily added to the clinical trial. Pregnant, ready for pregnant or lactating women; combining severe cardiovascular and cerebrovascular diseases, liver diseases, kidney diseases, hematopoietic diseases, diabetes mellitus with more than moderate degree, and osteoporosis; patients suffering from mental diseases, etc.
About 0.5g of the product is taken every day, the affected parts of lips are uniformly coated in a comparison mode of 1, 2, 3 and 5, the treatment effect is judged after 1-3 months of treatment. The effect was recorded by telephone return visit and review, and finally the average value was calculated as the number of heals, and the values are shown in table 2.
TABLE 2
| Lipstick name | Used for 1 month | For 2 months | Used for 3 months |
| The invention is that | 77.5％ | 100％ | / |
| Comparative 1 | 0％ | 0％ | 0％ |
| Comparative example 2 | 30％ | 65％ | 90％ |
| Comparative example 3 | 45％ | 82.5％ | 95％ |
| Comparative example 5 | 35％ | 72.5％ | 95％ |
The invention shows that the astragalus, the dangshen and the peach kernel have very good synergistic effect of treating cheilitis.
3. And (3) moisture preservation effect test:
the experimental object is the product of the invention and the comparison product. The testing method comprises the following steps: the test subjects were each coated on the same fabric to a thickness of 0.2 mm. Under the same conditions, 10 samples were applied to each subject. Each sample was dried at 40 ℃ for 5 hours, and the weights before and after drying were weighed using a one-ten-thousandth balance, and the moisturizing ability was calculated. Test results: 89% of the product; comparative 1 was 73%; comparative 2 was 83%; comparative 3 was 85%; comparative 4 was 79%; contrast 5 was 81%; comparative 6 was 73%.
4. Antibacterial performance test:
5g of the product according to the invention were taken and tested against products 1 to 6.
Inoculating Escherichia coli and staphylococcus aureus into a test tube culture medium, culturing in an incubator at 37 ℃ for 48 hours, adding sterile ultrapure water, and shaking to obtain an experimental bacterium suspension. 1mL of the test fungus suspension is dripped into the experimental lipstick, the suspension and the lipstick are uniformly mixed, and then the mixture is placed in a constant temperature box at 37 ℃ for 12 hours, the activity of the test fungus is detected, and the sterilization rate is calculated.
The experimental results are shown in Table 3.
TABLE 3 Table 3
| Lipstick name | Coli bacterium | Staphylococcus aureus |
| The invention is that | 100％ | 100％ |
| Comparative 1 | 1.5％ | 3.2％ |
| Comparative example 2 | 35.6％ | 31.5％ |
| Comparative example 3 | 46.3％ | 58.1％ |
| Comparative example 4 | 81.6％ | 92.3％ |
| Comparative example 5 | 86.7％ | 90.8％ |
| Comparative example 6 | 100％ | 100％ |
5. Other performance tests:
the product and the comparative lipstick were tested by the following methods for melting point, breaking force, coloring ability, moistening degree, transparency, stability, safety and durability.
(1) Melting point: adopting a VIC melting point measuring method of the appendix of 2010 edition of Chinese pharmacopoeia;
(2) Breaking force: the lipstick fracture meter was used for testing. In general, lipstick with the diameter of 12.7mm has the breaking force in the range of 400-800 g, so that the lipstick is not easy to break in the use process;
(3) Coloring ability and moisturizing degree: the actual use sensory evaluation is adopted, the 5-score is good, the 4-score is good, the 3-score is general, the 2-score is poor, and the 1-score is poor; data were recorded after evaluation by 50 users (20 students, 30 cosmetics sold) and averaged;
(4) Stability: the test is carried out for 3 months under four conditions of 25 ℃, 18 ℃ below zero, 48 ℃ below zero and 48 ℃ and has no change after normal temperature recovery, and the test can be normally used, and the test is taken as an evaluation standard.
The test results are shown in tables 4 and 5:
TABLE 4 Table 4
| Lipstick name | Melting point (. Degree. C.) | Breaking force | Degree of moistening | Coloring power | Stability of |
| The invention is that | 66 | 518 | 4.8 | 4.7 | Qualified product |
| Comparative 1 | 63 | 501 | 4.8 | 4.6 | Qualified product |
| Comparative example 2 | 65 | 524 | 4.7 | 4.6 | Qualified product |
| Comparative example 3 | 68 | 536 | 4.6 | 4.7 | Qualified product |
| Comparative example 4 | 65 | 495 | 4.4 | 4.4 | Qualified product |
| Comparative example 5 | 69 | 528 | 4.6 | 4.5 | Qualified product |
| Comparative example 6 | 70 | 514 | 4.3 | 4.6 | Qualified product |
TABLE 5
As can be seen from Table 5, the lipstick for preventing cheilitis of the present invention is safe, has no irritation and no toxicity.
Durability test:
the experimental object is the product of the invention and the comparison product. The testing method comprises the following steps: after 10 minutes of lipstick coating, the white porcelain cup is closed down, the mark remained on the cup edge is observed, and the lip marks are displayed, namely, after 10 minutes of lipstick coating, the lip marks are printed on the oil absorbing paper, and the residual quantity of the lip marks is observed. A total of 50 users were invited to participate in the test and averaged. The full score is 20 minutes. Test results: the invention is 17 minutes; comparative 1 was 13.5 minutes; comparative 2 was 14.5 minutes; comparative 3 is 14 points; comparative 4 is 10.5 minutes; comparative 5 is 16 points; comparative 6 was 18 minutes. It can be seen that the product of the invention has good durability.
Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present invention, and the present invention is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present invention has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (3)
1. The Chinese herbal medicine lipstick with the cheilitis prevention function is characterized by being prepared from the following raw materials in parts by weight: 18 parts of astragalus water extract, 5 parts of astragalus diethyl ether extract, 5 parts of codonopsis pilosula water extract, 2 parts of codonopsis pilosula diethyl ether extract, 15 parts of peach kernel extract, 21 parts of beeswax, 1 part of edible toner, 4 parts of hyaluronic acid, 5 parts of jasmine flower wax, 1 part of tea polyphenol, 8 parts of olive oil, 4 parts of refined chicken oil, 1 part of vitamin C, 1 part of diisostearyl malate, 7 parts of food-grade vaseline and 2 parts of modified attapulgite;
the astragalus water extract is water-soluble extract powder, and the preparation method comprises the following steps: cleaning astragalus, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding ultrapure water with the mass of 20 times of the astragalus, stirring for 30 minutes at a low temperature and with the ultrasonic power of 60kHz at the temperature of 20 ℃ at the stirring speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the high-temperature high-pressure difference continuous cell wall crushing conditions are as follows: concentrating the water solution at 15 deg.C under 300Mpa at 3L/h flow rate to water content not higher than 10%, freeze drying at-25deg.C for 48 hr, and pulverizing to 1500 mesh to obtain radix astragali water-soluble extract powder;
the astragalus root diethyl ether extract is diethyl ether extract powder, and the preparation method comprises the following steps: cleaning astragalus, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding anhydrous diethyl ether with the mass of 10 times, stirring for 30 minutes at a low temperature and ultrasonic power of 60kHz at the temperature of 20 ℃, and stirring at the speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the high-temperature high-pressure difference continuous cell wall crushing conditions are as follows: distilling at 15 deg.C under 300MPa at 3L/h flow rate under reduced pressure to remove diethyl ether completely, distilling at 50 deg.C under-0.1 MPa, and pulverizing to 1500 mesh to obtain radix astragali diethyl ether extract powder;
the radix codonopsis water extract is water-soluble extract powder, and the preparation method comprises the following steps: cleaning radix codonopsis pilosulae, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding ultrapure water with the mass of 20 times of the radix codonopsis pilosulae, stirring at a low temperature for 30 minutes under the condition of 20 ℃ and the ultrasonic power of 60kHz at the stirring speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the crushing conditions of the high-temperature high-pressure difference continuous cell wall are as follows: concentrating the aqueous solution at 15 deg.C under 300Mpa at 3L/h flow rate until the water content is not higher than 10%, freeze drying at-25deg.C for 48 hr, and pulverizing to 1500 mesh to obtain radix Codonopsis water-soluble extract powder;
the codonopsis pilosula diethyl ether extract is diethyl ether extract powder, and the preparation method comprises the following steps: cleaning radix codonopsis pilosulae, slicing, cutting into slices with the thickness of 2mm, superfine grinding to 800 meshes after drying, wherein the drying temperature is 85 ℃ and the time is 24 hours, adding anhydrous diethyl ether with the mass of 10 times, stirring for 30 minutes at a low temperature and with the ultrasonic power of 60kHz at the temperature of 20 ℃, and stirring at the speed of 200r/min, extracting water-soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, wherein the high-temperature high-pressure difference continuous cell wall crushing conditions are as follows: distilling at 15 deg.C under 300MPa at 3L/h flow rate under reduced pressure to remove diethyl ether completely, distilling at 50 deg.C under-0.1 MPa, and pulverizing to 1500 mesh to obtain radix Codonopsis diethyl ether extract powder;
the preparation method of the peach kernel extract comprises the following steps: cleaning peach kernels, drying, superfine grinding to 800 meshes, wherein the drying temperature is 85 ℃ for 24 hours, adding a mixed solvent with the mass of 20 times of that of the peach kernels, mixing the mixed solvent with ultrapure water with the volume ratio of 20% of ethanol to 80%, stirring the mixed solvent with ultrasonic at a low temperature for 30 minutes, wherein the temperature is 20 ℃, the ultrasonic power is 60kHz, the stirring speed is 200r/min, extracting organic solvent soluble essence components by using a low-temperature high-pressure difference continuous cell wall crushing extraction technology, and the low-temperature high-pressure difference continuous cell wall crushing conditions are as follows: freeze drying at 15deg.C under 300Mpa at 3L/h flow rate to remove solvent, freezing at-25deg.C, drying for 48 hr, and pulverizing to 1500 mesh to obtain semen Persicae extract powder;
the preparation method of the modified attapulgite comprises the following steps: preparing commercial sweet almond oil into an anhydrous diethyl ether solution with the mass concentration of 5% according to the condition that the solute is sweet almond oil and the solvent is anhydrous diethyl ether, dripping concentrated sulfuric acid with the mass of two parts per million of the sweet almond oil, stirring while dripping, then adding attapulgite powder with the mass of 20 times of the sweet almond oil, stirring at 60 ℃ for reflux reaction, and removing generated water while stirring until no water is generated; and (3) carrying out filter pressing on the obtained anhydrous product, wherein the filter pressing pressure is 0.159Mpa, adopting a microporous filter membrane with the diameter of 0.45 mu m, washing for 3-5 times by using ultrapure water, and carrying out spray drying at the temperature of 120 ℃ and the concentration of 10mL/min to ensure that the water content is not higher than 0.2%, thereby obtaining the modified attapulgite with the particle size of more than or equal to 3000 meshes.
2. The Chinese herbal medicine lipstick with the function of preventing cheilitis according to claim 1, wherein the preparation method of the refined chicken oil is as follows: collecting chicken oil in a freshly slaughtered hen, placing in an oil bath pan under nitrogen protection, heating and stirring at 120 ℃, and removing water by an oil-water separator while heating until no water is separated out to obtain refined chicken oil.
3. The method for preparing the Chinese herbal medicine lipstick with the cheilitis prevention function according to claim 1 or 2, which is characterized by comprising the following steps:
1) Blending the modified attapulgite with edible toner in a proportion, and ball-milling for 15min at 1400r/min to obtain a raw material S1;
2) Blending the refined chicken oil with the peach kernel extract in a proportion, performing ball milling for 25min at 1400r/min to obtain a raw material S2;
3) Mixing the astragalus water extract, the astragalus diethyl ether extract, the radix codonopsis water extract, the radix codonopsis diethyl ether extract, the tea polyphenol and the vitamin C according to the proportion, and ball milling for 10min at 1000r/min to obtain a raw material S3;
4) Mixing beeswax, jasmine wax and food-grade vaseline in a proportion, heating to 80 ℃ under the protection of 99.99% high-purity nitrogen gas for melting, and fully and uniformly stirring to obtain a raw material S4;
5) Uniformly mixing the hyaluronic acid, the olive oil and the diisostearyl alcohol malate in a ratio to obtain a raw material S5;
6) And (3) uniformly mixing the raw materials S1, S2, S3, S4 and S5 obtained in the steps 1) to 5), injecting the mixed materials into a mold, cooling to 8 ℃, demolding, shaping and boxing to obtain the Chinese herbal medicine lipstick with the cheilitis prevention function.
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