CN110051591A - A kind of spray containing trollflower hydrosol and its preparation and application - Google Patents
A kind of spray containing trollflower hydrosol and its preparation and application Download PDFInfo
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- CN110051591A CN110051591A CN201910442756.4A CN201910442756A CN110051591A CN 110051591 A CN110051591 A CN 110051591A CN 201910442756 A CN201910442756 A CN 201910442756A CN 110051591 A CN110051591 A CN 110051591A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
The invention belongs to cosmetic fields, and in particular to a kind of spray containing trollflower hydrosol and its preparation and application.The spray of the hydrosol provided by the invention containing trollflower includes following components and its mass fraction: 50-80 parts of trollflower compound, 30-40 parts of rose, 3-5 parts of camomile extract, 4-6 parts of moisturizer, 0.3-0.5 parts of allantoin, 0.1-0.3 parts of dipotassium glycyrrhizinate, 0.1-0.2 parts of hyaluronic acid, 0.1-0.3 parts of preservative, 8-15 parts of water.The spray of the hydrosol prepared by the present invention containing trollflower contains natural constituent, skin aging, moisturizing can be slowed down, promote skin blood circulation, also there is anti-oxidant, antiallergy, antibacterial anti-inflammatory and the effect that refreshes the mind, it can be applied in cosmetics, provide new formula for the exploitation of cosmetics.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of spray containing trollflower hydrosol and its preparation and answer
With.
Background technique
With the development of society and the progress of science and technology, the operating pressure of people is increasing, and rhythm of life is constantly accelerated, and leads
The skin tolerance of people is caused constantly to weaken, skin sensitivity, impaired situation are increasingly severe, and more and more application on human skin are in
Existing sub-health state.Therefore, skin nursing has been increasingly becoming indispensable a part in people's life.
The common beauty product of people has facial mask, toner, face cream and lotion etc..But these beauty products use step
It is rapid cumbersome, it needs to be applied to face with hand, pollution sources is easy to take on skin, and inconvenient to carry, Bu Nengsui mostly
When protect skin everywhere.Aerosol type skin care item are the novel skin care item risen in recent years, as long as spray-like skin care item gently press
Shin moisturizer can be sprayed onto face, with, fine droplet forms silky protective film on skin, skin care maintenance while
The injury of extraneous sunlight and pollution to skin has also been isolated.The design of spray-like skin care item nozzle can use to avoid skin care item
In secondary pollution, and spray-like skin care item are easy to carry, can protect skin anywhere or anytime, meet modern to skin care
The demand of product.
Currently, the effect of spray on the market mainly pays attention to moisturizing, whitening, nti-freckle, but these sprays often can
There are the substances of some being irritating to the skin property, and the phenomenon that being easy to appear inflammation, allergy is used for a long time.Plant extracts is from pure
It extracts and is made in natural plant, containing there are many have the effect of sterilization, anti-inflammatory, antipruritic active constituent, and no pair
Effect.Skin care item containing plant extracts are increasingly liked by people seeking beauty.Therefore, a kind of energy taste is researched and developed out
Moisten skin, slow down skin aging, while there is anti-oxidant, antiallergy, the spray of antibacterial and anti-inflammation functions, is current makeup conduct
The hot spot of industry research.
104922244 B of Chinese patent CN discloses a kind of rose spray and preparation method thereof for alleviating eye strain.
The rose spray mainly consist of the following components: rose extract, Rosa Damascana, trehalose, rilanit special, penta 2
Alcohol, dipotassium glycyrrhizinate, menthol, preservative, Sodium Hyaluronate, propylene glycol, butanediol and water.Preparation method is first with the third two
Pure and mild butanediol dissolves Sodium Hyaluronate, and separately plus pentanediol dissolves menthol, and plus hydrogenated castor oil mixes Rosa Damascana,
Above-mentioned three kinds of solution is mixed and remaining component is added to obtain the final product.The rose spray of the invention is sprayed directly on to the surrounding of eye, can be with
Promote eye part skin microcirculation, improve ocular angiogenesis blood flow, reduce intraocular pressure, thus reach alleviate eye strain and eyesight it is tired
The effect of labor；It also has excellent water-retaining property simultaneously, it is possible to reduce eye pouch is tightened in eye muscle relaxation, is a kind of with shield
The antifatigue spray of the eye of skin function.But the invention is just for eye skin, although can moisturizing, not by anti-oxidant function again
Effect has certain limitation.
Current existing spray mostly has certain limitation, and function is not comprehensive enough, and has some main components not
It is enough pure natural, it is not easy to be used for a long time.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of spray containing trollflower hydrosol and its
Preparation and application.The spray of the hydrosol provided by the invention containing trollflower has multiple functions, can slow down skin aging, moisten
Skin, promote skin blood circulation, also have anti-oxidant, antiallergy, antibacterial anti-inflammatory and the effect that refreshes the mind, while its mainly at
Dividing is pure natural substance, is used safely and effectively.
The technical scheme is that
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: trollflower compound 50-80
Part, 30-40 parts of rose, 3-5 parts of camomile extract, 4-6 parts of moisturizer, 0.3-0.5 parts of allantoin, dipotassium glycyrrhizinate
0.1-0.3 parts, 0.1-0.2 parts of hyaluronic acid, 0.1-0.3 parts of preservative, 8-15 parts of water.
Further, the trollflower compound is made of trollflower hydrosol and ice vegetable juice 4-7:2-5 in mass ratio.
Further, the moisturizer is made of Pfansteihl sodium, chitosan oligosaccharide and trehalose 2-4:1-3:2-4 in mass ratio.
Further, the rose is prepared by following methods:
(a) it takes in rose investment distillation still, the water of 3-4 times of rose weight is added, adds rose weight 6%-
12% salt accesses steam heated still, heats 4-6h, and vapour pressure is controlled in 0.05-0.2MPa, is heated to temperature in the kettle
When being 60-65 DEG C, opens condenser and cooling water is added, obtain mixed liquor；
(b) mixed liquor obtained by step (a) is imported in oil water separator and isolates distillate, resurgent returns in distillation still, receives
Collect water layer liquid, obtains rose.
Further, the camomile extract is prepared by following methods:
(1) chamomile is added in extraction kettle, carbon dioxide is passed through with 30-50L/h flow velocity, concentration, which is added, by 1-2L/h is
The ethyl alcohol of 75%-80% extracts 2-3h under conditions of temperature remains 40 DEG C -60 DEG C, pressure is 10-15MPa；By extract
It is put into pillar separating still and separates, obtain chamomile ORGANIC SOLVENT MIXTURES；
(2) chamomile ORGANIC SOLVENT MIXTURES obtained by step (1) is put into decompression low-temperature concentration equipment, be depressurized to-
0.05-0.05MPa recycles organic solvent under the conditions of 45-55 DEG C, obtains camomile extract.
Further, the trollflower hydrosol is prepared by following methods:
(I) trollflower is fitted into the medicinal material column for being connected to silicagel column, hexamethylene recycling elution, flow control 1- is added
2BV/h removes silicagel column after eluting 3-4h, and 2-4 times of trollflower weight of hexamethylene flushing silicagel column is added, add by
20% ethyl acetate and 80% hexamethylene composition mixed liquor recycling elution, flow control 1-2BV/h, elute 2-3h,
Recycling design in Rotary Evaporators is added in eluent, obtains trollflower oil extractum；
(II) mixing being made of the dehydrated alcohol and hexamethylene of equivalent will be added in trollflower oil extractum obtained by step (I)
Liquid ultrasonic dissolution 20-40min, the mixed liquor are 2-3 times of trollflower oil extractum weight, and stratification takes lower liquid,
It is distilled at 95 DEG C, when fraction volume is the 110%-120% of ethyl alcohol and hexamethylene total volume, abandons fraction；Again by temperature
100 DEG C are increased to, the fraction at a temperature of 100 DEG C is collected, obtains trollflower hydrosol.
Further, the ice vegetable juice is prepared by following methods: the water equal with ice dish quality will be added in ice dish, sufficiently
Grinding crosses 200-300 mesh filter screen, obtains ice vegetable juice.
Further, the preservative is one or both of Phenoxyethanol and Sensiva SC50.
Another object of the present invention is to provide the preparation method of the spray of the hydrosol containing trollflower described in one kind, packets
Include following steps:
S1 heats water to 50 DEG C -80 DEG C, and allantoin is added, and stirs to being completely dissolved, obtains allantoin liquid；
Hyaluronic acid is added in glycerol and stirs evenly by S2, obtains mixed liquor A；
S3 mixes moisturizer with rose, camomile extract, obtains mixed liquid B；
S4 is compound by mixed liquid B obtained by mixed liquor A obtained by allantoin liquid, step S2 obtained by step S1, step S3, trollflower
Object, dipotassium glycyrrhizinate and preservative mixing, stir evenly to get.
Another object of the present invention is, application of the spray of the hydrosol containing trollflower in cosmetics.
Compared with prior art, present invention has the advantage that
1, the spray of the hydrosol prepared by the present invention containing trollflower contains the trollflower of trollflower hydrosol and ice vegetable juice composition
Compound, the combination of the two is so that the spray of the hydrosol containing trollflower has good antioxygenic property.
2, the spray of the hydrosol prepared by the present invention containing trollflower contains the guarantor of Pfansteihl sodium, chitosan oligosaccharide and trehalose composition
Humectant, so that the spray of the hydrosol containing trollflower of preparation has superior performance of keeping humidity.
3, the spray main component of the hydrosol prepared by the present invention containing trollflower is natural component, and it is old can to slow down skin
Change, moisturizing promote skin blood circulation, have antiallergy, antibacterial anti-inflammatory and the effect that refreshes the mind.
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, is all within the scope of the present invention.
A kind of spray of the hydrosol containing trollflower of embodiment 1
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 50 parts of trollflower compound, rose
30 parts of rare hydrosol, 3 parts of camomile extract, 4 parts of moisturizer, 0.3 part of allantoin, 0.1 part of dipotassium glycyrrhizinate, hyaluronic acid 0.1
Part, 0.1 part of preservative, 8 parts of water；The trollflower compound is made of trollflower hydrosol and ice vegetable juice 4:2 in mass ratio；It is described
Moisturizer is made of Pfansteihl sodium, chitosan oligosaccharide and trehalose 2:1:2 in mass ratio；The preservative is Sensiva SC50.
The rose is prepared by following methods:
(a) it takes in rose investment distillation still, 3 times of rose weight of water is added, adds the food of rose weight 6
Salt accesses steam heated still, heats 4h, and vapour pressure control when to be heated to temperature in the kettle be 60 DEG C, is opened in 0.05MPa
Cooling water is added in condenser, obtains mixed liquor；
(b) mixed liquor obtained by step (a) is imported in oil water separator and isolates distillate, resurgent returns in distillation still, receives
Collect water layer liquid, obtains rose.
The camomile extract is prepared by following methods:
(1) chamomile is added in extraction kettle, carbon dioxide is passed through with 30L/h flow velocity, it is 75% that concentration, which is added, by 1L/h
Ethyl alcohol, temperature remain 40 DEG C, pressure be 10MPa under conditions of extract 3h；Extract is put into pillar separating still and is divided
From obtaining chamomile ORGANIC SOLVENT MIXTURES；
(2) chamomile ORGANIC SOLVENT MIXTURES obtained by step (1) is put into decompression low-temperature concentration equipment, be depressurized to-
0.05, organic solvent is recycled under the conditions of 45 DEG C, obtains camomile extract.
The trollflower hydrosol is prepared by following methods:
(I) trollflower is fitted into the medicinal material column for being connected to silicagel column, hexamethylene recycling elution, flow control 1BV/ is added
H removes silicagel column after eluting 3h, and the hexamethylene that 2 times of the trollflower weight is added rinses silicagel column, adds by 20% second
Acetoacetic ester and 80% hexamethylene composition mixed liquor recycling elution, flow control lV/h, elute 3h, by eluent be added revolve
Turn recycling design in evaporimeter, obtains trollflower oil extractum；
(II) by be added in trollflower oil extractum obtained by step (I) described 2 times of trollflower oil extractum weight by equivalent
The mixed liquor ultrasonic dissolution 20min of dehydrated alcohol and hexamethylene composition, stratification takes lower liquid, at a temperature of 95 DEG C into
Row distillation abandons fraction when fraction volume is greater than the 110% of ethyl alcohol and hexamethylene total volume；100 DEG C are raised the temperature to again,
The fraction at a temperature of 100 DEG C is collected, trollflower hydrosol is obtained.
The ice vegetable juice is prepared by following methods: the water equal with ice dish quality will be added in ice dish, is fully ground, mistake
200-300 mesh filter screen obtains ice vegetable juice.
The preparation method of the spray of the hydrosol containing trollflower, comprising the following steps:
S1 heats water to 50 DEG C, and allantoin is added, and stirs to being completely dissolved, obtains allantoin liquid；
Hyaluronic acid is added in glycerol and stirs evenly by S2, obtains mixed liquor A；
S3 mixes moisturizer with rose, camomile extract, obtains mixed liquid B；
S4 is compound by mixed liquid B obtained by mixed liquor A obtained by allantoin liquid, step S2 obtained by step S1, step S3, trollflower
Object, dipotassium glycyrrhizinate and preservative mixing, stir evenly to get.
A kind of spray of the hydrosol containing trollflower of embodiment 2
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 80 parts of trollflower compound, rose
40 parts of rare hydrosol, 5 parts of camomile extract, 6 parts of moisturizer, 0.5 part of allantoin, 0.3 part of dipotassium glycyrrhizinate, hyaluronic acid 0.2
Part, 0.3 part of preservative, 15 parts of water；The trollflower compound is made of trollflower hydrosol and ice vegetable juice 7:5 in mass ratio；Institute
Moisturizer is stated to be made of Pfansteihl sodium, chitosan oligosaccharide and trehalose 4:3:4 in mass ratio；The preservative is Phenoxyethanol and ethyl
Hexyl glycerol 1:1 in mass ratio composition.
The rose is prepared by following methods:
(a) it takes in rose investment distillation still, 4 times of rose weight of water is added, adds rose weight 12%
Salt accesses steam heated still, heats 6h, and vapour pressure control when to be heated to temperature in the kettle be 65 DEG C, is opened in 0.2MPa
Cooling water is added in condenser, obtains mixed liquor；
(b) mixed liquor obtained by step (a) is imported in oil water separator and isolates distillate, resurgent returns in distillation still, receives
Collect water layer liquid, obtains rose.
The camomile extract is prepared by following methods:
(1) chamomile is added in extraction kettle, carbon dioxide is passed through with 50L/h flow velocity, it is 80% that concentration, which is added, by 2L/h
Ethyl alcohol, temperature remain 60 DEG C, pressure be 15MPa under conditions of extract 2h；Extract is put into pillar separating still and is divided
From obtaining chamomile ORGANIC SOLVENT MIXTURES；
(2) chamomile ORGANIC SOLVENT MIXTURES obtained by step (1) is put into decompression low-temperature concentration equipment, is depressurized to
0.05MPa recycles organic solvent under the conditions of 55 DEG C, obtains camomile extract.
The trollflower hydrosol is prepared by following methods:
(I) trollflower is fitted into the medicinal material column for being connected to silicagel column, hexamethylene recycling elution, flow control 2BV/ is added
H removes silicagel column after eluting 4h, and the hexamethylene that 4 times of the trollflower weight is added rinses silicagel column, adds by 20% second
Acetoacetic ester and 80% hexamethylene composition mixed liquor recycling elution, flow control 2BV/h, elute 3h, eluent is added
Recycling design in Rotary Evaporators obtains trollflower oil extractum；
(II) by be added in trollflower oil extractum obtained by step (I) described 3 times of trollflower oil extractum weight by equivalent
The mixed liquor ultrasonic dissolution 40min of dehydrated alcohol and hexamethylene composition, stratification takes lower liquid, at a temperature of 95 DEG C into
Row distillation abandons fraction when fraction volume is greater than the 120% of ethyl alcohol and hexamethylene total volume；100 DEG C are raised the temperature to again,
The fraction at a temperature of 100 DEG C is collected, trollflower hydrosol is obtained.
The ice vegetable juice is prepared by following methods: the water equal with ice dish quality will be added in ice dish, is fully ground, mistake
200-300 mesh filter screen obtains ice vegetable juice.
The preparation method of the spray of the hydrosol containing trollflower, comprising the following steps:
S1 heats water to 80 DEG C, and allantoin is added, and stirs to being completely dissolved, obtains allantoin liquid；
Hyaluronic acid is added in glycerol and stirs evenly by S2, obtains mixed liquor A；
S3 mixes moisturizer with rose, camomile extract, obtains mixed liquid B；
S4 is compound by mixed liquid B obtained by mixed liquor A obtained by allantoin liquid, step S2 obtained by step S1, step S3, trollflower
Object, dipotassium glycyrrhizinate and preservative mixing, stir evenly to get.
A kind of spray of the hydrosol containing trollflower of embodiment 3
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 65 parts of trollflower compound, rose
35 parts of rare hydrosol, 4 parts of camomile extract, 5 parts of moisturizer, 0.4 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, hyaluronic acid 0.1
Part, 0.2 part of preservative, 10 parts of water；The trollflower compound is made of trollflower hydrosol and ice vegetable juice 5:3 in mass ratio；Institute
Moisturizer is stated to be made of Pfansteihl sodium, chitosan oligosaccharide and trehalose 3:2:3 in mass ratio；The preservative is Phenoxyethanol and ethyl
Hexyl glycerol 1:1 in mass ratio composition.
The rose is prepared by following methods:
(a) it takes in rose investment distillation still, 4 times of rose weight of water is added, adds the food of rose weight 8%
Salt accesses steam heated still, heats 5h, and vapour pressure control when to be heated to temperature in the kettle be 62 DEG C, is opened cold in 0.1MPa
Cooling water is added in condenser, obtains mixed liquor；
(b) mixed liquor obtained by step (a) is imported in oil water separator and isolates distillate, resurgent returns in distillation still, receives
Collect water layer liquid, obtains rose.
The camomile extract is prepared by following methods:
(1) chamomile is added in extraction kettle, carbon dioxide is passed through with 40L/h flow velocity, it is 78% that concentration, which is added, by 1L/h
Ethyl alcohol, temperature remain 50 DEG C, pressure be 13MPa under conditions of extract 3h；Extract is put into pillar separating still and is divided
From obtaining chamomile ORGANIC SOLVENT MIXTURES；
(2) chamomile ORGANIC SOLVENT MIXTURES obtained by step (1) is put into decompression low-temperature concentration equipment, is depressurized to
0.02MPa recycles organic solvent under the conditions of 50 DEG C, obtains camomile extract.
The trollflower hydrosol is prepared by following methods:
(I) trollflower is fitted into the medicinal material column for being connected to silicagel column, hexamethylene recycling elution, flow control 2BV/ is added
H removes silicagel column after eluting 4h, and the hexamethylene that 3 times of the trollflower weight is added rinses silicagel column, adds by 20% second
Acetoacetic ester and 80% hexamethylene composition mixed liquor recycling elution, flow control 1BV/h, elute 3h, eluent is added
Recycling design in Rotary Evaporators obtains trollflower oil extractum；
(II) by be added in trollflower oil extractum obtained by step (I) described 2 times of trollflower oil extractum weight by equivalent
The mixed liquor ultrasonic dissolution 30min of dehydrated alcohol and hexamethylene composition, stratification takes lower liquid, at a temperature of 95 DEG C into
Row distillation abandons fraction when fraction volume is greater than the 115% of ethyl alcohol and hexamethylene total volume；100 DEG C are raised the temperature to again,
The fraction at a temperature of 100 DEG C is collected, trollflower hydrosol is obtained.
The ice vegetable juice is prepared by following methods: the water equal with ice dish quality will be added in ice dish, is fully ground, mistake
200-300 mesh filter screen obtains ice vegetable juice.
The preparation method of the spray of the hydrosol containing trollflower, comprising the following steps:
S1 heats water to 65 DEG C, and allantoin is added, and stirs to being completely dissolved, obtains allantoin liquid；
Hyaluronic acid is added in glycerol and stirs evenly by S2, obtains mixed liquor A；
S3 mixes moisturizer with rose, camomile extract, obtains mixed liquid B；
S4 is compound by mixed liquid B obtained by mixed liquor A obtained by allantoin liquid, step S2 obtained by step S1, step S3, trollflower
Object, dipotassium glycyrrhizinate and preservative mixing, stir evenly to get.
A kind of spray of the hydrosol containing trollflower of embodiment 4
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 70 parts of trollflower compound, rose
35 parts of rare hydrosol, 3 parts of camomile extract, 6 parts of moisturizer, 0.3 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, hyaluronic acid 0.15
Part, 0.1 part of preservative, 11 parts of water；The trollflower compound is made of trollflower hydrosol and ice vegetable juice 6:5 in mass ratio；Institute
Moisturizer is stated to be made of Pfansteihl sodium, chitosan oligosaccharide and trehalose 3:2:2 in mass ratio；The preservative is Phenoxyethanol.
The rose is prepared by following methods:
(a) it takes in rose investment distillation still, 3 times of rose weight of water is added, adds rose weight 10%
Salt accesses steam heated still, heats 5h, and vapour pressure control when to be heated to temperature in the kettle be 60 DEG C, is beaten in 0.15MPa
It opens condenser and cooling water is added, obtain mixed liquor；
(b) mixed liquor obtained by step (a) is imported in oil water separator and isolates distillate, resurgent returns in distillation still, receives
Collect water layer liquid, obtains rose.
The camomile extract is prepared by following methods:
(1) chamomile is added in extraction kettle, carbon dioxide is passed through with 40L/h flow velocity, it is 80% that concentration, which is added, by 2L/h
Ethyl alcohol, temperature remain 50 DEG C, pressure be 12MPa under conditions of extract 3h；Extract is put into pillar separating still and is divided
From obtaining chamomile ORGANIC SOLVENT MIXTURES；
(2) chamomile ORGANIC SOLVENT MIXTURES obtained by step (1) is put into decompression low-temperature concentration equipment, is depressurized to
0.01MPa recycles organic solvent under the conditions of 50 DEG C, obtains camomile extract.
The trollflower hydrosol is prepared by following methods:
(I) trollflower is fitted into the medicinal material column for being connected to silicagel column, hexamethylene recycling elution, flow control 2BV/ is added
H removes silicagel column after eluting 4h, and the hexamethylene that 2 times of the trollflower weight is added rinses silicagel column, adds by 20% second
Acetoacetic ester and 80% hexamethylene composition mixed liquor recycling elution, flow control 2BV/h, elute 2h, eluent is added
Recycling design in Rotary Evaporators obtains trollflower oil extractum；
(II) by be added in trollflower oil extractum obtained by step (I) described 3 times of trollflower oil extractum weight by equivalent
The mixed liquor ultrasonic dissolution 35min of dehydrated alcohol and hexamethylene composition, stratification takes lower liquid, at a temperature of 95 DEG C into
Row distillation abandons fraction when fraction volume is greater than the 110% of ethyl alcohol and hexamethylene total volume；100 DEG C are raised the temperature to again,
The fraction at a temperature of 100 DEG C is collected, trollflower hydrosol is obtained.
The ice vegetable juice is prepared by following methods: the water equal with ice dish quality will be added in ice dish, is fully ground, mistake
200-300 mesh filter screen obtains ice vegetable juice.
The preparation method of the spray of the hydrosol containing trollflower, comprising the following steps:
S1 heats water to 50 DEG C, and allantoin is added, and stirs to being completely dissolved, obtains allantoin liquid；
Hyaluronic acid is added in glycerol and stirs evenly by S2, obtains mixed liquor A；
S3 mixes moisturizer with rose, camomile extract, obtains mixed liquid B；
S4 is compound by mixed liquid B obtained by mixed liquor A obtained by allantoin liquid, step S2 obtained by step S1, step S3, trollflower
Object, dipotassium glycyrrhizinate and preservative mixing, stir evenly to get.
A kind of spray of the hydrosol containing trollflower of comparative example 1
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 65 parts of trollflower hydrosol, rose
35 parts of hydrosol, 4 parts of camomile extract, 5 parts of moisturizer, 0.4 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, 0.1 part of hyaluronic acid,
0.2 part of preservative, 10 parts of water；The moisturizer is made of Pfansteihl sodium, chitosan oligosaccharide and trehalose 3:2:3 in mass ratio；It is described
Preservative is that Phenoxyethanol and Sensiva SC50 1:1 in mass ratio are formed.
The preparation method of the rose is similar to Example 3.
The preparation method of the camomile extract is similar to Example 3.
The preparation method of the trollflower hydrosol is similar to Example 3.
The preparation method of the spray of the hydrosol containing trollflower is similar to Example 3, and the difference with embodiment 3 exists
In the spray of the prepared hydrosol containing trollflower is free of ice dish.
A kind of spray of the hydrosol containing trollflower of comparative example 2
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 65 parts of trollflower compound, rose
35 parts of rare hydrosol, 4 parts of camomile extract, 5 parts of moisturizer, 0.4 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, hyaluronic acid 0.1
Part, 0.2 part of preservative, 10 parts of water；The trollflower compound is made of trollflower hydrosol and ice vegetable juice 5:3 in mass ratio；Institute
Stating moisturizer is chitosan oligosaccharide；The preservative is that Phenoxyethanol and Sensiva SC50 1:1 in mass ratio are formed.
The preparation method of the rose is similar to Example 3.
The preparation method of the camomile extract is similar to Example 3.
The preparation method of the trollflower hydrosol is similar to Example 3.
The preparation method of the ice vegetable juice is similar to Example 3.
The preparation method of the spray of the hydrosol containing trollflower is similar to Example 3, and the difference with embodiment 3 exists
In the moisturizer is chitosan oligosaccharide, is free of Pfansteihl sodium and trehalose.
A kind of spray of the hydrosol containing trollflower of comparative example 3
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 65 parts of trollflower compound, rose
35 parts of rare hydrosol, 4 parts of camomile extract, 5 parts of moisturizer, 0.4 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, hyaluronic acid 0.1
Part, 0.2 part of preservative, 10 parts of water；The trollflower compound is made of trollflower hydrosol and ice vegetable juice 5:3 in mass ratio；Institute
Stating moisturizer is Pfansteihl sodium.The preservative is that Phenoxyethanol and Sensiva SC50 1:1 in mass ratio are formed.
The preparation method of the rose is similar to Example 3.
The preparation method of the camomile extract is similar to Example 3.
The preparation method of the trollflower hydrosol is similar to Example 3.
The preparation method of the ice vegetable juice is similar to Example 3.
The preparation method of the spray of the hydrosol containing trollflower is similar to Example 3, and the difference with embodiment 3 exists
In the moisturizer is Pfansteihl sodium, is free of chitosan oligosaccharide and trehalose.
A kind of spray of the hydrosol containing trollflower of comparative example 4
A kind of spray of the hydrosol containing trollflower, including following components and its mass fraction: 65 parts of trollflower compound, rose
35 parts of rare hydrosol, 4 parts of camomile extract, 5 parts of moisturizer, 0.4 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, hyaluronic acid 0.1
Part, 0.2 part of preservative, 10 parts of water；The trollflower compound is made of trollflower hydrosol and ice vegetable juice 5:3 in mass ratio；Institute
Stating moisturizer is trehalose；The preservative is that Phenoxyethanol and Sensiva SC50 1:1 in mass ratio are formed.
The preparation method of the rose is similar to Example 3.
The preparation method of the camomile extract is similar to Example 3.
The preparation method of the trollflower hydrosol is similar to Example 3.
The preparation method of the ice vegetable juice is similar to Example 3.
The preparation method of the spray of the hydrosol containing trollflower is similar to Example 3, and the difference with embodiment 3 exists
In the moisturizer is trehalose, is free of Pfansteihl sodium and chitosan oligosaccharide.
The spray moistening effect of 1 hydrosol containing trollflower of experimental example is tested
1, experimental material: the spray of the hydrosol containing trollflower made from embodiment 1-4, comparative example 2-4.
2, experimental method:
70 volunteers are collected, 70 volunteers are randomly divided into 7 groups, every group of 10 people smear embodiment 1 respectively, implement
The spray of the hydrosol containing trollflower made from example 2, embodiment 3, embodiment 4, comparative example 2, comparative example 3, comparative example 4 in hand,
It smears 2 times, is used continuously 3 days daily, and detect the moisture using rear volunteer's hand skin with VISIA skin detection instrument.
3, experimental result: experimental result is as shown in table 1.
1 volunteer's hand skin water content detection result of table
As can be seen from Table 3, the spray of the hydrosol containing trollflower made from embodiment 1-4 has good moisture retention
Can, compared with each embodiment, the performance of keeping humidity of comparative example 2-4 is very poor, illustrates that the trehalose, Pfansteihl sodium and shell of single component are few
Sugar cannot all significantly improve the performance of keeping humidity of the spray of the hydrosol containing trollflower, when three's combination, can significantly improve containing lily feet
The performance of keeping humidity of the spray of flower hydrosol, and embodiment 3 is significantly better than other embodiments on performance of keeping humidity, it is best for the present invention
Embodiment.
The spray bacteriostatic test of 2 hydrosol containing trollflower of experimental example
1, experimental material: the spray of the hydrosol containing trollflower made from embodiment 1, embodiment 2, embodiment 3, embodiment 4.
2, experimental method: 0.5mL is taken to be added drop-wise to culture respectively the spray of the hydrosol containing trollflower made from embodiment 1-4
In ware, same amount of normal saline is added dropwise in blank group, and then inoculum density is 7.0 × 10 respectively4The Pseudomonas aeruginosa of CFU/mL, 30min
After test bacterial number.
3, test result: the results are shown in Table 2.
The spray bacteriostasis property result of 2 hydrosol containing trollflower of table
As can be seen from Table 2, compared to the blank group, the quantity of the Pseudomonas aeruginosa of embodiment 1-4 significantly reduces, explanation
The spray of the hydrosol produced by the present invention containing trollflower has good bacteriostasis property, and embodiment 3 is significant on bacteriostasis property
It is preferred embodiment better than other embodiments.
The spray Oxidation Resistance Test of 3 hydrosol containing trollflower of experimental example
1, experimental material: hydrosol containing trollflower made from embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1
Spray.
2, antioxygenic property experimental method: is measured with DPPH Scavenging activity, comprising the following steps:
(1) 0.0197g DPPH powder accurately is taken, is settled to 250mL with dehydrated alcohol, is configured to the DPPH of 0.2mmol/L
Stock solution measures absorbance A at 517nm0, 0 DEG C of preservation；
(2) the spray 0.2mL of Example 1-4 and the hydrosol obtained containing trollflower of comparative example 1, with 4mL acetate buffer
Solution and the mixing of 3.8mL ethyl alcohol, obtain sample to be tested, measure the absorbance A at 517nm.；
(3) each analyte sample fluid 0.5mL is taken respectively, and the DPPH stock solution of 2.5mL is added, it is anti-in 28 DEG C of thermostat water baths
30min is answered, measuring absorbance at 517nm with ultraviolet specrophotometer is Ab, clearance rate=[A of DPPH free radical0(A-
Ab)]/A0。
3, experimental result: experimental result is as shown in table 3.
The spray DPPH Scavenging activity result of 3 hydrosol containing trollflower of table
As can be seen from Table 3, compared with each comparative example 1, each embodiment free radical removal effect is significantly improved, explanation
The antioxygenic property of the spray of the hydrosol containing trollflower and real can be significantly improved when the combination of trollflower hydrosol and ice vegetable juice
The antioxidant effect for applying example 3 is best, is most preferred embodiment.
Claims (10)
1. a kind of spray of hydrosol containing trollflower, which is characterized in that including following components and its mass fraction: trollflower is compound
50-80 parts of object, 30-40 parts of rose, 3-5 parts of camomile extract, 4-6 parts of moisturizer, 0.3-0.5 parts of allantoin, Radix Glycyrrhizae
Sour dipotassium 0.1-0.3 parts, 0.1-0.2 parts of hyaluronic acid, 0.1-0.3 parts of preservative, 8-15 parts of water.
2. the spray of the hydrosol according to claim 1 containing trollflower, which is characterized in that the trollflower compound is by gold
Lotus flower hydrosol and ice vegetable juice 4-7:2-5 in mass ratio composition.
3. the spray of the hydrosol according to claim 1 containing trollflower, which is characterized in that the moisturizer is by Pfansteihl
Sodium, chitosan oligosaccharide and trehalose 2-4:1-3:2-4 in mass ratio composition.
4. the spray of the hydrosol according to claim 1 containing trollflower, which is characterized in that the rose is by with lower section
Method preparation:
(a) it takes in rose investment distillation still, the water of 3-4 times of rose weight is added, adds rose weight 6%-12%
Salt, access steam heated still, heat 4-6h, vapour pressure control in 0.05-0.2MPa, being heated to temperature in the kettle is
At 60-65 DEG C, opens condenser and cooling water is added, obtain mixed liquor；
(b) mixed liquor obtained by step (a) is imported in oil water separator and isolates distillate, resurgent returns in distillation still, collects water
Layer liquid, obtains rose.
5. the spray of the hydrosol according to claim 1 containing trollflower, which is characterized in that the camomile extract by with
The preparation of lower section method:
(1) chamomile is added in extraction kettle, carbon dioxide is passed through with 30-50L/h flow velocity, concentration, which is added, by 1-2L/h is
The ethyl alcohol of 75%-80% extracts 2-3h under conditions of temperature remains 40 DEG C -60 DEG C, pressure is 10-15MPa；By extract
It is put into pillar separating still and separates, obtain chamomile ORGANIC SOLVENT MIXTURES；
(2) chamomile ORGANIC SOLVENT MIXTURES obtained by step (1) is put into decompression low-temperature concentration equipment, is depressurized to -0.05-
0.05MPa recycles organic solvent under the conditions of 45-55 DEG C, obtains camomile extract.
6. the spray of the hydrosol according to claim 2 containing trollflower, which is characterized in that the trollflower hydrosol is by following
Method preparation:
(I) trollflower is fitted into the medicinal material column for being connected to silicagel column, addition hexamethylene recycling elution, flow control 1-2BV/h,
Silicagel column is removed after elution 3-4h, 2-4 times of trollflower weight of the hexamethylene is added and rinses silicagel column, adds by 20%
Ethyl acetate and 80% hexamethylene composition mixed liquor recycling elution, flow control 1-2BV/h, elute 2-3h, will elute
Recycling design in Rotary Evaporators is added in liquid, obtains trollflower oil extractum；
(II) it will be added in trollflower oil extractum obtained by step (I) and surpassed by the mixed liquor that the dehydrated alcohol and hexamethylene of equivalent form
Sound dissolves 20-40min, and the mixed liquor is 2-3 times of trollflower oil extractum weight, and stratification takes lower liquid, at 95 DEG C
Under distilled, when fraction volume is the 110%-120% of ethyl alcohol and hexamethylene total volume, abandon fraction；Temperature is increased again
To 100 DEG C, the fraction at a temperature of 100 DEG C is collected, trollflower hydrosol is obtained.
7. the spray of the hydrosol according to claim 2 containing trollflower, which is characterized in that the ice vegetable juice is by following methods
Preparation: the water equal with ice dish quality will be added in ice dish, is fully ground, cross 200-300 mesh filter screen, obtain ice vegetable juice.
8. the spray of the hydrosol according to claim 1 containing trollflower, which is characterized in that the preservative is Phenoxyethanol
One or both of with Sensiva SC50.
9. the preparation method of the spray of the hydrosol according to claim 1-8 containing trollflower, which is characterized in that packet
Include following steps:
S1 heats water to 50 DEG C -80 DEG C, and allantoin is added, and stirs to being completely dissolved, obtains allantoin liquid；
Hyaluronic acid is added in glycerol and stirs evenly by S2, obtains mixed liquor A；
S3 mixes moisturizer with rose, camomile extract, obtains mixed liquid B；
S4 by mixed liquid B obtained by mixed liquor A obtained by allantoin liquid, step S2 obtained by step S1, step S3, trollflower compound,
Dipotassium glycyrrhizinate and preservative mixing, stir evenly to get.
10. application of the spray of the hydrosol according to claim 1-8 containing trollflower in cosmetics.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111773152A (en) * | 2020-07-08 | 2020-10-16 | 田汐 | Rose-glacier spring fragrance SPA spray formula |
| CN113318052A (en) * | 2021-06-29 | 2021-08-31 | 浙江宜格企业管理集团有限公司 | Preparation method of compound flower extract with multiple skin care effects |
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| CN108096086A (en) * | 2016-11-25 | 2018-06-01 | 深圳市弘创农业科技有限公司 | A kind of method that the ice plant extract without preservative is prepared using ice plant freeze-dried powder |
| CN109355136A (en) * | 2018-11-05 | 2019-02-19 | 广东大鹏医药科技有限公司 | A kind of preparation method and its handmade soap of lily feet flower essential oil |
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| CN105326691A (en) * | 2015-11-11 | 2016-02-17 | 广州暨南生物医药研究开发基地有限公司 | Spray agent containing wormwood hydrolat and preparation method of spray agent |
| CN108096086A (en) * | 2016-11-25 | 2018-06-01 | 深圳市弘创农业科技有限公司 | A kind of method that the ice plant extract without preservative is prepared using ice plant freeze-dried powder |
| CN109355136A (en) * | 2018-11-05 | 2019-02-19 | 广东大鹏医药科技有限公司 | A kind of preparation method and its handmade soap of lily feet flower essential oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111773152A (en) * | 2020-07-08 | 2020-10-16 | 田汐 | Rose-glacier spring fragrance SPA spray formula |
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Application publication date: 20190726 |