CN105326691A - Spray agent containing wormwood hydrolat and preparation method of spray agent - Google Patents
Spray agent containing wormwood hydrolat and preparation method of spray agent Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention belongs to the technical field of cosmetics and particularly relates to a spray agent containing wormwood hydrolat and a preparation method thereof. The spray agent containing wormwood hydrolat is mainly prepared from the wormwood hydrolat, rose hydrolat, chamomile extract, trehalose, allantoin, dipotassium glycyrrhizinate, hyaluronic acid, glycerinum, preservative and water. The spray agent containing the wormwood hydrolat has the functions of sterilization property, antianaphylaxis and antiphlogosis and itching relieving of broad spectrum and meanwhile has the effects of slowing down skin aging, promoting blood circulation of skin, supplementing water, moisturizing, refreshing and restoring consciousness. The spray agent containing wormwood hydrolat is free of stimulation to skin, the phenomenon of skin poisoning can be avoided after the spray agent is used for a long time, and the spray agent is suitable for being used for various people, especially suitable for being used by people with sensitive skin.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of spray containing Folium Artemisiae Argyi hydrosol and preparation method thereof.
Background technology
Along with the development of society and the progress of science and technology, the operating pressure of people is increasing, and rhythm of life is constantly accelerated, and causes the skin tolerance of people constantly to weaken, skin sensitivity, impaired situation are more and more serious, and the skin of more and more people presents sub-health state.Therefore, skin nursing becomes an indispensable part in people's life gradually.
The cosmetics that people commonly use have facial film, astringent, facial cream and emulsion etc.But these cosmetics use step more loaded down with trivial details, need to be applied in face with hands, easily polluter are taken on skin, and mostly carry inconvenience, can not protect skin whenever and wherever possible.Aerosol type skin care item are the novel skin care item risen in recent years; as long as spray-like skin care item gently press just can skin care liquid be sprayed onto face, with it; the fine globule forms silkiness protecting film on skin, the injury also isolated extraneous sunlight and polluted skin while skin protection maintenance.The design of spray-like skin care item nozzle, the secondary pollution during skin care item can be avoided to use, and also spray-like skin care item are easy to carry, can protect skin anywhere or anytime, meet the demand of modern to skin care item.
At present, spray on the market mainly pays attention to effect of moisturizing, whitening, speckle dispelling, but these sprays often can exist some to skin material excitatory, and inflammation, irritated phenomenon easily appear in life-time service.Plant extract extracts to obtain from the plant of pure natural, and it contains the multiple active component with sterilization, antiinflammatory, antipruritic effect, and is free from side effects.Therefore, the skin care item containing plant extract are more and more subject to liking to be beautiful liking of personage.
Chinese patent application 201210462719.8 discloses a kind of moisturizing spraying, described moisturizing spraying is primarily of raw material compositions such as natto elite extracting solution, Mel elite, Semen Armeniacae Amarum elite extracting solution, vitamin C and distilled water, the moistening effect of this moisturizing spraying is good, have no side effect, the crowd being applicable to dry skin uses.
Chinese patent application 201410684032.8 discloses a kind of water-setting containing Cordyceps militaris (L.) Link. composition and sprays and preparation method thereof, described water-setting spraying comprises Aloe fermented product, hydrolysis avenin, Cordyceps extracting solution, hydrolysis Lac regis apis, Herba portulacae extract, Folium Kaki extract, orange peel extract, phellinus linteus extract, Salix Babylonica L.P.E, vanilla extract, Lengxiang rose flower extract, green tea extract, Radix Astragali root extract, Radix Ginseng extract, tricholoma matsutake, Radix Arnebiae extract, camomile extract, tree moss extract, the effective ingredient such as Flos Lonicerae extract.The water-setting spraying prepared has safety non-toxic, crease-resistant feature, and production cost is lower, is applicable to the use of many people.
But crease-resistant, whitening on the market at present, moisturizing spray all exist certain zest to skin, and the phenomenon of dermal toxicity easily appears in life-time service, be not suitable for sensitivity skin and the impaired crowd of facial skin uses.Therefore, studying and send out and output a kind of energy Glycerin, slow down skin aging, have the spray of antioxidation, antiallergic, antibacterial and anti-inflammation functions simultaneously, is the focus of current cosmetic industry research.
Summary of the invention
The poor defect of antiinflammatory, antiallergic effect is there is in order to solve aerosol type skin care item in prior art, the object of the present invention is to provide one to have and slow down skin aging, Glycerin, promotion cutaneous circulation, also there is spray containing Folium Artemisiae Argyi hydrosol and preparation method thereof of antioxidation, antiallergic, anti-inflammation and refreshment effect, to address the aforementioned drawbacks.
The invention provides a kind of spray containing Folium Artemisiae Argyi hydrosol, comprise following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 50-80 part, MEIGUI CHUNLU 20-40 part, camomile extract 2-6 part, trehalose 1-4 part, allantoin 0.1-0.5 part, glycyrrhizic acid dipotassium 0.1-0.6 part, hyaluronic acid 0.05-0.2 part, glycerol 1-3 part, antiseptic 0.1-0.5 part and water 5-20 part.
Further, the described spray containing Folium Artemisiae Argyi hydrosol comprises following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 65 parts, MEIGUI CHUNLU 35 parts, camomile extract 4 parts, trehalose 3 parts, allantoin 0.4 part, glycyrrhizic acid dipotassium 0.2 part, hyaluronic acid 0.1 part, glycerol 2 parts, antiseptic 0.2 part and 10 parts, water.
Further, the preparation method of described Folium Artemisiae Argyi hydrosol is:
Getting Folium Artemisiae Argyi loading is connected in the medical material post of silicagel column, add cyclohexane extraction recycling elution, flow speed control is 1-2BV/h, pull down silicagel column after eluting 3-4h, use above-mentioned Folium Artemisiae Argyi weight 2-4 cyclohexane extraction doubly to rinse silicagel column, add the mixed liquor recycling elution be made up of the ethyl acetate of 20% and the cyclohexane extraction of 80%, flow speed control is 1-2BV/h, eluting 2-3h, adds recycling design in Rotary Evaporators by eluent, obtain Oleum Folium Artemisiae Argyi extractum; Then the above-mentioned Oleum Folium Artemisiae Argyi extractum weight 2-3 mixed liquor ultrasonic dissolution 20-40min be made up of dehydrated alcohol and the cyclohexane extraction of equivalent is doubly added, stratification, take off a layer liquid, distill at 95 DEG C of temperature, when fraction volume is greater than the 110-120% of ethanol and cyclohexane extraction cumulative volume, abandon fraction; Temperature is increased to 100 DEG C, collects the fraction at 100 DEG C of temperature, obtain Folium Artemisiae Argyi hydrosol.
Further, the preparation method of described MEIGUI CHUNLU is:
Getting Flos Rosae Rugosae drops in distillating still, add Flos Rosae Rugosae weight 3-4 water doubly, then add the Sal of Flos Rosae Rugosae weight 6-12%, access steam heated still, heating 4-6h, vapour pressure controls at 0.05-0.2MPa, when to be heated to temperature in the kettle be 60-65 DEG C, open condenser and adds cooling water, above-mentioned mixed liquor is imported in oil water separator and isolates distillate, resurgent returns in distillating still, collects water layer liquid, obtains MEIGUI CHUNLU.
Further, the preparation method of described camomile extract is:
Getting Flos Matricariae chamomillae adds in extraction kettle, passes into carbon dioxide with 30-50L/h flow velocity, adds by 1-2L/h the ethanol that concentration is 75%-80%, remains 40-60 DEG C, pressure extracts 2-3h under being the condition of 10-15MPa in temperature; Extract is put into pillar separating still to be separated, obtain Flos Matricariae chamomillae ORGANIC SOLVENT MIXTURES; Put it in decompression low-temperature concentration equipment, decompression, to-0.05-0.05MPa, is reclaimed organic solvent, is obtained camomile extract under 45-55 DEG C of condition again.
Further, described antiseptic is one in phenoxyethanol and Sensiva SC50 or its compositions.
Provided by the invention have containing the Folium Artemisiae Argyi hydrosol in the spray of Folium Artemisiae Argyi hydrosol the effect slowing down skin aging, Glycerin, promotion cutaneous circulation and refreshment, and to no skin irritation, be a kind of pure natural, non-stimulated cosmetic composition.MEIGUI CHUNLU refines a kind of side-product in Flos Rosae Rugosae quintessence oil process, its have keep the skin wet, moisturizing, bactericidal antiphlogistic, antiallergic, antipruritic and slow down aging effect.
Camomile extract contains the active ingredients such as a large amount of volatile oil, choline, stachydrine, aminoacid, flavonoid, Flos Chrysanthemi lactone, chrysanthone and chrysol, it has balanced fat secretion, press down the anti-pox of fat, prevent acne, eliminate black speck, skin whitening, the effect of anti-inflammation and sterilization is a kind of good skin care ingredient.
In spray containing Folium Artemisiae Argyi hydrosol provided by the invention, trehalose can form unique protecting film at cell surface under the severe environmental conditions such as high temperature, high and cold, hyperosmosis and dry dehydration; effectively can maintain cytoactive, to skin, there is good protective effect.Allantoin has Promote cell's growth, accelerating wound, horny layer softening albumen, effect of moisturizing moisturizing.Find through test, trehalose and allantoin conbined usage, better can maintain cytoactive, strengthens the moisturizing to skin and moisture-keeping function.Spray of the present invention also with the addition of glycyrrhizic acid dipotassium and hyaluronic acid further, further can promote percutaneous absorption, can effectively reduce zest and the anaphylaxis of skin.
Spray containing Folium Artemisiae Argyi hydrosol provided by the invention has the effect of the bactericidal properties of wide spectrum, antianaphylaxis and anti-inflammatory anti-itch, also has to slow down skin aging, promote cutaneous circulation, moisturizing, moisturizing, the effect of refreshment simultaneously.Make skin moisten after using fine and smooth, flexible, be applicable to all kinds of crowd and use, the crowd being especially applicable to sensitivity skin uses, and is a kind of aerosol type skin care item meeting modern and require.
In addition, present invention also offers a kind of preparation method of the spray containing Folium Artemisiae Argyi hydrosol, comprise the following steps:
S1 heats water to 50-80 DEG C, adds allantoin, is stirred to and dissolves completely, obtains allantoin liquid;
Hyaluronic acid adds in glycerol and stirs by S2, obtains mixed liquor;
The mixed liquor that allantoin liquid and step S2 that step S1 obtains by S3 obtain is mixed homogeneously, and then adds Folium Artemisiae Argyi hydrosol, MEIGUI CHUNLU, camomile extract, trehalose, glycyrrhizic acid dipotassium and antiseptic, stirs, to obtain final product.
Compared with prior art, the spray containing Folium Artemisiae Argyi hydrosol provided by the invention has following advantage:
(1) spray containing Folium Artemisiae Argyi hydrosol provided by the invention has the effect of the bactericidal properties of wide spectrum, antianaphylaxis and anti-inflammatory anti-itch, also have simultaneously and slow down skin aging, promotion cutaneous circulation, moisturizing, moisturizing, the effect of refreshment is a kind of aerosol type skin care item meeting modern and require;
(2) spray containing Folium Artemisiae Argyi hydrosol provided by the invention is to no skin irritation, and life-time service there will not be the phenomenon of dermal toxicity, is applicable to all kinds of crowd and uses, and the crowd being especially applicable to sensitivity skin uses.
detailed description of the invention:
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.Each component of the present invention is conventional commercial product, and such as: allantoin is purchased from Merck KGaA company, model is: RonaCareAllantion101015; Trehalose is purchased from Noah bio tech ltd, Henan, and No. CAS: 99-20-7.
embodiment 1,the preparation of Folium Artemisiae Argyi hydrosol
Getting Folium Artemisiae Argyi loading is connected in the medical material post of silicagel column, add cyclohexane extraction recycling elution, flow speed control is 2BV/h, pull down silicagel column after eluting 3h, use the cyclohexane extraction of above-mentioned Folium Artemisiae Argyi weight 3 times to rinse silicagel column, add the mixed liquor recycling elution be made up of the ethyl acetate of 20% and the cyclohexane extraction of 80%, flow speed control is 1BV/h, eluting 2h, adds recycling design in Rotary Evaporators by eluent, obtain Oleum Folium Artemisiae Argyi extractum; Then the mixed liquor ultrasonic dissolution 20min be made up of dehydrated alcohol and the cyclohexane extraction of equivalent of above-mentioned Oleum Folium Artemisiae Argyi extractum weight 2 times is added, stratification, takes off a layer liquid, distills at 95 DEG C of temperature, when fraction volume is greater than 120% of ethanol and cyclohexane extraction cumulative volume, abandon fraction; Temperature is increased to 100 DEG C, collects the fraction at 100 DEG C of temperature, obtain Folium Artemisiae Argyi hydrosol.
embodiment 2,the preparation of MEIGUI CHUNLU
Getting Flos Rosae Rugosae drops in distillating still, add the water of Flos Rosae Rugosae weight 3 times, then add the Sal of Flos Rosae Rugosae weight 6%, access steam heated still, heating 4h, vapour pressure controls at 0.05MPa, when to be heated to temperature in the kettle be 60 DEG C, open condenser and adds cooling water, above-mentioned mixed liquor is imported in oil water separator and isolates distillate, resurgent returns in distillating still, collects water layer liquid, obtains MEIGUI CHUNLU.
embodiment 3,the preparation of camomile extract
Getting Flos Matricariae chamomillae adds in extraction kettle, passes into carbon dioxide with 30L/h flow velocity, adds by 1L/h the ethanol that concentration is 75%, remains 40 DEG C, pressure extracts 2h under being the condition of 10MPa in temperature; Extract is put into pillar separating still to be separated, obtain Flos Matricariae chamomillae ORGANIC SOLVENT MIXTURES; Put it in decompression low-temperature concentration equipment, decompression, to 0.01MPa, is reclaimed organic solvent, is obtained camomile extract under 50 DEG C of conditions again.
embodiment 4,a kind of spray containing Folium Artemisiae Argyi hydrosol
The described spray containing Folium Artemisiae Argyi hydrosol comprises following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 50 parts, MEIGUI CHUNLU 20 parts, camomile extract 2 parts, trehalose 1 part, allantoin 0.2 part, glycyrrhizic acid dipotassium 0.1 part, hyaluronic acid 0.05 part, glycerol 1 part, antiseptic 0.1 part and 5 parts, water.
Preparation method:
S1 heats water to 60 DEG C, adds allantoin, is stirred to and dissolves completely, obtains allantoin liquid;
Hyaluronic acid adds in glycerol and stirs by S2, obtains mixed liquor;
The mixed liquor that allantoin liquid and step S2 that step S1 obtains by S3 obtain is mixed homogeneously, and then adds Folium Artemisiae Argyi hydrosol, MEIGUI CHUNLU, camomile extract, trehalose, glycyrrhizic acid dipotassium and antiseptic, stirs, to obtain final product.
embodiment 5,a kind of spray containing Folium Artemisiae Argyi hydrosol
The described spray containing Folium Artemisiae Argyi hydrosol comprises following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 65 parts, MEIGUI CHUNLU 35 parts, camomile extract 4 parts, trehalose 3 parts, allantoin 0.4 part, glycyrrhizic acid dipotassium 0.2 part, hyaluronic acid 0.1 part, glycerol 2 parts, antiseptic 0.2 part and 10 parts, water.
Preparation method is similar to Example 4.
embodiment 6,a kind of spray containing Folium Artemisiae Argyi hydrosol
The described spray containing Folium Artemisiae Argyi hydrosol comprises following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 80 parts, MEIGUI CHUNLU 40 parts, camomile extract 6 parts, trehalose 4 parts, allantoin 0.5 part, glycyrrhizic acid dipotassium 0.5 part, hyaluronic acid 0.2 part, glycerol 3 parts, antiseptic 0.3 part and 20 parts, water.
Preparation method is similar to Example 4.
comparative example 1,a kind of spray containing Folium Artemisiae Argyi hydrosol
The described spray containing Folium Artemisiae Argyi hydrosol comprises following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 65 parts, MEIGUI CHUNLU 35 parts, trehalose 3 parts, allantoin 0.4 part, glycyrrhizic acid dipotassium 0.2 part, hyaluronic acid 0.1 part, glycerol 2 parts, antiseptic 0.2 part and 10 parts, water.
Preparation method is similar to Example 4.
comparative example 2,a kind of spray containing Folium Artemisiae Argyi hydrosol
The described spray containing Folium Artemisiae Argyi hydrosol comprises following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 65 parts, MEIGUI CHUNLU 35 parts, camomile extract 4 parts, trehalose 3 parts, glycyrrhizic acid dipotassium 0.2 part, hyaluronic acid 0.1 part, glycerol 2 parts, antiseptic 0.2 part and 10 parts, water.
Preparation method is similar to Example 4.
test example one,containing the bacteriostatic test of the spray of Folium Artemisiae Argyi hydrosol
1, test material: the spray containing Folium Artemisiae Argyi hydrosol of embodiment 4, embodiment 5, embodiment 6 and comparative example 1 preparation.
2, for the preparation of examination bacterium
Respectively escherichia coli, staphylococcus aureus, Bacillus thuringiensis, bacillus subtilis are seeded in Carnis Bovis seu Bubali cream culture fluid in aseptic processing room, aspergillosis, beer yeast and candida mycoderma are seeded in bean sprout juice culture fluid, under 28-30 DEG C of condition, cultivate 1-30.
3, test method:
Adopt agar punching diffusion method, sterile petri dish is divided into 5 groups, often organize 3, Carnis Bovis seu Bubali cream culture fluid after sterilizing is poured in sterile petri dish, every ware 15 ~ 20mL, after it solidifies, draw 0.1mL escherichia coli, staphylococcus aureus and bacillus subtilis with Sterile pipette is added on culture dish for examination bacterium, and coating evenly, is often organized each culture dish and added different strains.
Sterile petri dish is divided into 5 groups, often organize 3, bean sprout juice culture fluid after sterilizing is poured in sterile petri dish, every ware 15 ~ 20mL, after it solidifies, draw 0.1mL aspergillosis, beer yeast and candida mycoderma with Sterile pipette is added on culture dish for examination bacterium, coating evenly, is often organized each culture dish and is added different strains.
After coating, then in culture medium, make a call to 5 equidistant holes with the sterilizing stainless steel card punch of external diameter 4mm.With the aerosol fluid 30 μ L containing Folium Artemisiae Argyi hydrosol of micro sample adding appliance difference extraction embodiment 4, embodiment 5, embodiment 6 and comparative example 1 preparation, a middle hole is added normal saline and is done matched group, carries out labelling.Cultivate 24h at antibacterial being placed in 37 DEG C, at Molds and yeasts being placed in 28 DEG C, cultivate 72h.Measure antibacterial circle diameter (bacteriostatic diameter mm counts), test repetition 5 times, with 5 meansigma methodss for antibacterial circle diameter.
4, result of the test
Result of the test is as shown in table 1.
Table 1 is containing the bacteriostatic test data of the spray of Folium Artemisiae Argyi hydrosol
As shown in Table 1, spray containing Folium Artemisiae Argyi hydrosol prepared by the present invention has significant inhibitory action to escherichia coli, staphylococcus aureus and bacillus subtilis, to aspergillosis, beer yeast and candida mycoderma, there is good inhibitory action, and comparative example 1 has lacked camomile extract, it is poor to the fungistatic effect of escherichia coli, staphylococcus aureus, bacillus subtilis, aspergillosis, beer yeast and candida mycoderma, illustrates that Folium Artemisiae Argyi hydrosol, MEIGUI CHUNLU and camomile extract are used in combination and can work in coordination with enhancing bacteriostasis.
test example two,containing the evaluation test of the spray of Folium Artemisiae Argyi hydrosol
1, test material: the spray containing Folium Artemisiae Argyi hydrosol of embodiment 4, embodiment 5, embodiment 6, comparative example 1 and comparative example 2 preparation.
2, tested crowd: choose 50 routine female volunteers, the age between 20 ~ 40 years old, volunteer choice criteria: there are small pox or impaired female volunteers in sensitivity skin, face.
3, test method:
Volunteer is divided into 5 groups at random, is respectively embodiment 4 groups, embodiment 5 groups, embodiment 6 groups, comparative example 1 group and comparative example 2 groups, often organizes 10 people.After each group of volunteer cleans face, use the spray containing Folium Artemisiae Argyi hydrosol in face, every day 3-5 time, use 4 weeks continuously.
Mark to the moisturizing effect of the spray containing Folium Artemisiae Argyi hydrosol, antipruritic, antianaphylaxis, anti-inflammatory effects and whole structure after using 4 weeks, methods of marking is:
(1) moisturizing effect: 3 effects are fine, and 2 is effective, 1 effect is general, and 0 does not have effect;
(2) antipruritic: 3 effects are fine, and 2 is effective, 1 effect is general, and 0 does not have effect;
(3) antianaphylaxis: 3 without allergic phenomena, 2 somewhat red, itch, 1 has a sensation of pricking, red, itches, and 0 has a sensation of pricking, red, itches;
(4) anti-inflammatory effects: 3 effects are fine, and small pox or swelling and ache of erythema are disappeared, and 2 is effective, and small pox or erythema are not keenly felt, 1 effect is general, and small pox or swelling and ache of erythema also exist, and 0 does not have effect, and small pox or erythema swell and ache seriously;
(5) whole structure: 3 effects are fine, and 2 is effective, 1 effect is general, and 0 does not have effect.
4, result of the test:
Result of the test is as shown in table 2.
Table 2 is containing (4 weeks) on probation feedback conclusive table of the spray of Folium Artemisiae Argyi hydrosol
| Embodiment 4 groups | Embodiment 5 groups | Embodiment 6 groups | Comparative example 1 group | Comparative example 2 groups | |
| Moisturizing effect | 28 | 30 | 28 | 26 | 10 |
| Antipruritic | 30 | 30 | 30 | 14 | 27 |
| Antianaphylaxis | 30 | 30 | 30 | 10 | 26 |
| Anti-inflammatory effects | 29 | 30 | 30 | 10 | 25 |
| Whole structure | 30 | 30 | 30 | 10 | 20 |
As shown in Table 2, the spray containing Folium Artemisiae Argyi hydrosol prepared by the present invention has significant effect in moisturizing, antipruritic, antianaphylaxis and antiinflammatory etc., and overall assessment effect is fine, is a kind of aerosol type skin care item meeting modern and require.
test example three,containing the irritation test of the spray of Folium Artemisiae Argyi hydrosol
1, test material: the spray containing Folium Artemisiae Argyi hydrosol of embodiment 4, embodiment 5 and embodiment 6 preparation.
2, test method:
Method of testing with reference to " cosmetics health specification " (version in 2007) skin irritation measures the spray containing Folium Artemisiae Argyi hydrosol of embodiment 4, embodiment 5 and embodiment 6 preparation to the irritant effects of skin, marks to dermoreaction.
3, result of the test:
Draw through dermoreaction scoring, the integral estimation of the spray containing Folium Artemisiae Argyi hydrosol of embodiment 4, embodiment 5 and embodiment 6 preparation is all less than 0.5, to no skin irritation.
Claims (7)
1., containing a spray for Folium Artemisiae Argyi hydrosol, it is characterized in that, comprise following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 50-80 part, MEIGUI CHUNLU 20-40 part, camomile extract 2-6 part, trehalose 1-4 part, allantoin 0.1-0.5 part, glycyrrhizic acid dipotassium 0.1-0.6 part, hyaluronic acid 0.05-0.2 part, glycerol 1-3 part, antiseptic 0.1-0.5 part and water 5-20 part.
2. the spray containing Folium Artemisiae Argyi hydrosol as claimed in claim 1, is characterized in that, comprise following component and parts by weight thereof:
Folium Artemisiae Argyi hydrosol 65 parts, MEIGUI CHUNLU 35 parts, camomile extract 4 parts, trehalose 3 parts, allantoin 0.4 part, glycyrrhizic acid dipotassium 0.2 part, hyaluronic acid 0.1 part, glycerol 2 parts, antiseptic 0.2 part and 10 parts, water.
3. the spray containing Folium Artemisiae Argyi hydrosol as claimed in claim 1 or 2, it is characterized in that, the preparation method of described Folium Artemisiae Argyi hydrosol is:
Getting Folium Artemisiae Argyi loading is connected in the medical material post of silicagel column, add cyclohexane extraction recycling elution, flow speed control is 1-2BV/h, pull down silicagel column after eluting 3-4h, use above-mentioned Folium Artemisiae Argyi weight 2-4 cyclohexane extraction doubly to rinse silicagel column, add the mixed liquor recycling elution be made up of the ethyl acetate of 20% and the cyclohexane extraction of 80%, flow speed control is 1-2BV/h, eluting 2-3h, adds recycling design in Rotary Evaporators by eluent, obtain Oleum Folium Artemisiae Argyi extractum; Then the above-mentioned Oleum Folium Artemisiae Argyi extractum weight 2-3 mixed liquor ultrasonic dissolution 20-40min be made up of dehydrated alcohol and the cyclohexane extraction of equivalent is doubly added, stratification, take off a layer liquid, distill at 95 DEG C of temperature, when fraction volume is greater than the 110-120% of ethanol and cyclohexane extraction cumulative volume, abandon fraction; Temperature is increased to 100 DEG C, collects the fraction at 100 DEG C of temperature, obtain Folium Artemisiae Argyi hydrosol.
4. the spray containing Folium Artemisiae Argyi hydrosol as claimed in claim 1 or 2, it is characterized in that, the preparation method of described MEIGUI CHUNLU is:
Getting Flos Rosae Rugosae drops in distillating still, add Flos Rosae Rugosae weight 3-4 water doubly, then add the Sal of Flos Rosae Rugosae weight 6-12%, access steam heated still, heating 4-6h, vapour pressure controls at 0.05-0.2MPa, when to be heated to temperature in the kettle be 60-65 DEG C, open condenser and adds cooling water, above-mentioned mixed liquor is imported in oil water separator and isolates distillate, resurgent returns in distillating still, collects water layer liquid, obtains MEIGUI CHUNLU.
5. the spray containing Folium Artemisiae Argyi hydrosol as claimed in claim 1 or 2, it is characterized in that, the preparation method of described camomile extract is:
Getting Flos Matricariae chamomillae adds in extraction kettle, passes into carbon dioxide with 30-50L/h flow velocity, adds by 1-2L/h the ethanol that concentration is 75%-80%, remains 40-60 DEG C, pressure extracts 2-3h under being the condition of 10-15MPa in temperature; Extract is put into pillar separating still to be separated, obtain Flos Matricariae chamomillae ORGANIC SOLVENT MIXTURES; Put it in decompression low-temperature concentration equipment, decompression, to-0.05-0.05MPa, is reclaimed organic solvent, is obtained camomile extract under 45-55 DEG C of condition again.
6. the spray containing Folium Artemisiae Argyi hydrosol as claimed in claim 1 or 2, is characterized in that, described antiseptic is one in phenoxyethanol and Sensiva SC50 or its compositions.
7. a preparation method for the spray containing Folium Artemisiae Argyi hydrosol as described in as arbitrary in claim 1-6, is characterized in that, comprise the following steps:
S1 heats water to 50-80 DEG C, adds allantoin, is stirred to and dissolves completely, obtains allantoin liquid;
Hyaluronic acid adds in glycerol and stirs by S2, obtains mixed liquor;
The mixed liquor that allantoin liquid and step S2 that step S1 obtains by S3 obtain is mixed homogeneously, and then adds Folium Artemisiae Argyi hydrosol, MEIGUI CHUNLU, camomile extract, trehalose, glycyrrhizic acid dipotassium and antiseptic, stirs, to obtain final product.
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| CN201510777693.XA CN105326691B (en) | 2015-11-11 | 2015-11-11 | A kind of spray of the hydrosol containing wormwood and preparation method thereof |
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Cited By (12)
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| CN106635528A (en) * | 2016-11-21 | 2017-05-10 | 徐大鹏 | Antibacterial fancy soap containing Chinese herbal medicinal ingredients and preparation method thereof |
| CN106727032A (en) * | 2017-01-20 | 2017-05-31 | 邓袖华 | A kind of multi-functional hydrosol and preparation method thereof |
| CN107334700A (en) * | 2017-06-26 | 2017-11-10 | 四川森态源生物科技有限公司 | Face cleaning konjaku cotton and preparation method thereof |
| CN108371642A (en) * | 2018-03-09 | 2018-08-07 | 广东暨晴生物医药科技有限公司 | A kind of spring equilibrium water and preparation method thereof |
| CN109260138A (en) * | 2018-10-13 | 2019-01-25 | 广州禾安化工有限公司 | A kind of Shu Min repairs spraying and its production method |
| CN109453040A (en) * | 2018-12-07 | 2019-03-12 | 安阳工学院 | A kind of nanoscale wormwood odor type facial mask basal liquid and preparation method thereof |
| CN109576062A (en) * | 2019-02-12 | 2019-04-05 | 无锡薇泰药物技术有限公司 | A kind of Chinese yew hydrosol extraction process |
| CN109602662A (en) * | 2019-01-25 | 2019-04-12 | 无锡悦禧玫瑰科技有限公司 | A kind of preparation method of rose lotion |
| CN110051592A (en) * | 2019-05-25 | 2019-07-26 | 艾依诺科技有限公司 | A kind of folium artemisiae argyi essence moisturizing is spraying and its spray bottle |
| CN110051591A (en) * | 2019-05-25 | 2019-07-26 | 广东大鹏医药科技有限公司 | A kind of spray containing trollflower hydrosol and its preparation and application |
| CN110141548A (en) * | 2019-05-25 | 2019-08-20 | 艾依诺科技有限公司 | A kind of unitary aerosol using Folium Artemisiae Argyi extract and its spray bottle used |
| CN110152346A (en) * | 2018-04-09 | 2019-08-23 | 嘉兴市寒疆芳草生物科技有限公司 | It is a kind of to resist antibacterial chamomile hydrosol extracting method |
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| CN106635528A (en) * | 2016-11-21 | 2017-05-10 | 徐大鹏 | Antibacterial fancy soap containing Chinese herbal medicinal ingredients and preparation method thereof |
| CN106727032A (en) * | 2017-01-20 | 2017-05-31 | 邓袖华 | A kind of multi-functional hydrosol and preparation method thereof |
| CN107334700A (en) * | 2017-06-26 | 2017-11-10 | 四川森态源生物科技有限公司 | Face cleaning konjaku cotton and preparation method thereof |
| CN108371642A (en) * | 2018-03-09 | 2018-08-07 | 广东暨晴生物医药科技有限公司 | A kind of spring equilibrium water and preparation method thereof |
| CN110152346A (en) * | 2018-04-09 | 2019-08-23 | 嘉兴市寒疆芳草生物科技有限公司 | It is a kind of to resist antibacterial chamomile hydrosol extracting method |
| CN109260138A (en) * | 2018-10-13 | 2019-01-25 | 广州禾安化工有限公司 | A kind of Shu Min repairs spraying and its production method |
| CN109453040A (en) * | 2018-12-07 | 2019-03-12 | 安阳工学院 | A kind of nanoscale wormwood odor type facial mask basal liquid and preparation method thereof |
| CN109602662A (en) * | 2019-01-25 | 2019-04-12 | 无锡悦禧玫瑰科技有限公司 | A kind of preparation method of rose lotion |
| CN109576062A (en) * | 2019-02-12 | 2019-04-05 | 无锡薇泰药物技术有限公司 | A kind of Chinese yew hydrosol extraction process |
| CN110051592A (en) * | 2019-05-25 | 2019-07-26 | 艾依诺科技有限公司 | A kind of folium artemisiae argyi essence moisturizing is spraying and its spray bottle |
| CN110051591A (en) * | 2019-05-25 | 2019-07-26 | 广东大鹏医药科技有限公司 | A kind of spray containing trollflower hydrosol and its preparation and application |
| CN110141548A (en) * | 2019-05-25 | 2019-08-20 | 艾依诺科技有限公司 | A kind of unitary aerosol using Folium Artemisiae Argyi extract and its spray bottle used |
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