CN111388384A - Acne-removing essence containing Chinese herbal medicine composition and preparation method thereof - Google Patents
Acne-removing essence containing Chinese herbal medicine composition and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention discloses acne-removing essence containing a Chinese herbal medicine composition and a preparation method thereof, wherein the acne-removing essence is prepared from the following raw materials in percentage by weight: 3-8% of Yushui kudzu root extract, 5-10% of cotton rose hibiscus extract, 8-12% of trichosanthes root extract, 5-10% of spina gleditsiae extract, 5-10% of aloe extract, 5-15% of dandelion extract, 16-24% of eucalyptus leaf extract and the balance of water. Compared with the prior art, the technical scheme provided by the invention has the advantages that the components are scientifically matched and reasonably formulated, and the active substances capable of promoting the metabolism of cutin can be obtained; anti-inflammatory substances capable of rapidly killing skin parasitic flora such as propionibacterium acnes and mites; and active substances which provide moisture and nutrient components for the skin, keep the skin balanced and moist but not greasy, and repair the damaged skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to acne-removing essence containing a Chinese herbal medicine composition and a preparation method thereof.
Background
Acne, commonly called acne by doctors, is also known as whelk because it is usually found in young people. Acne is a kind of hair follicle sebaceous gland and its common chronic inflammatory dermatosis, and its pathogenesis is mainly: 1. hyperkeratosis of hair follicles and clogging of pores; 2. endothelial hyperplasia, exuberant sebum secretion; 3. infection by propionibacterium acnes bacteria; the pathological form of whelk occurs on the top layer of the skin, which is different from whitening, black spots and wrinkles, etc. occurring on the inner layer of the skin.
The appearance of whelk has serious influence on the life of people: 1. temporary scars: the red marks produced by the skin are called erythema. Whelk inflammation causes vasodilatation, forming a temporary erythema. Pigmentation after whelk inflammation can make skin dark; 2. permanent scar: whelk can leave permanent marks, most commonly pits, which can cause the collapse of skin and leave pits when the collagen of more dermis layers is damaged by a heavier inflammation degree; 3. psychological damage: recent studies have found that people suffering from acne are more likely to have the following: social disjointing, lack of self-esteem, no confidence, bad impression, embarrassment, depression, anger, frustration and high unemployment rate, under the interaction of the situations, patients do not want to pursue life opportunities, and many young people feel self-inferior and do not know how to deal with other people, so that the fear of abandoning is feared.
The origin of whelk is closely related to factors such as excessive sebum secretion, blockage of pilosebaceous ducts, bacterial infection and inflammatory reaction. After adolescence, the level of androgen, particularly testosterone, in a human body is rapidly increased, the development of sebaceous glands is promoted, and a large amount of sebum is produced. Meanwhile, abnormal keratinization of the pilosebaceous canal causes the canal to be blocked, sebum is obstructed to be discharged, and a keratoplug, namely micro acne, is formed. A number of microorganisms in the hair follicle, particularly propionibacterium acnes, multiply in number, and lipases produced by propionibacterium acnes break down sebum to produce free fatty acids, while chemotactic inflammatory cells and mediators, ultimately inducing and exacerbating the inflammatory response.
For acne with serious degree, the treatment modes of taking traditional Chinese medicines and antibiotics can be selected. However, this is a means used in an acute attack stage, and long-term use causes adverse phenomena such as allergy, which is detrimental to health. However, elimination of pox is more of a solution to the extrinsic factors of the skin than to the intrinsic problems of the skin itself.
Disclosure of Invention
Aiming at the technical defects, the invention aims to provide the acne removing essence prepared from the acne removing composition containing the Chinese herbal medicine extract, which is safe and has a good acne removing effect, and the preparation method thereof.
In order to solve the technical problems, the invention adopts the following technical scheme:
the invention provides acne-removing essence containing a Chinese herbal medicine composition, which is prepared from the following raw materials in percentage by weight: 3-8% of Yushui kudzu root extract, 5-10% of cotton rose hibiscus extract, 8-12% of trichosanthes root extract, 5-10% of spina gleditsiae extract, 5-10% of aloe extract, 5-15% of dandelion extract, 16-24% of eucalyptus leaf extract and the balance of water.
Preferably, the composition also comprises 1-4% of rhubarb extract.
The invention also provides a preparation method of the acne-removing essence containing the Chinese herbal medicine composition, which comprises the steps of mixing the raw materials in proportion, heating to 60-80 ℃, uniformly stirring, cooling and filtering to obtain the finished product of the acne-removing essence.
Preferably, the aloe extract is prepared by the following steps: peeling fresh aloe, cutting, placing in clean and sterilized cloth bag, squeezing to obtain aloe juice, and filtering with 80 mesh nylon gauze to obtain aloe extract.
Preferably, the eucalyptus leaf extract is prepared by the following steps: weighing folium Eucalypti Globueli, placing in a flask, adding water 2-3 times of folium Eucalypti Globueli, soaking for 0.3-1 hr, and distilling in 100 deg.C water bath for 0.8-1.2 hr to obtain distilled fluid extract.
Preferably, the extraction method of the pouzolzia extract, the cotton rose hibiscus extract, the trichosanthes root extract, the spina gleditsiae extract, the dandelion extract and the rheum officinale extract is any one of high-pressure-difference low-temperature continuous extraction separation and concentration technology or supercritical extraction.
The supercritical extraction method and the high-efficiency high-pressure-difference low-temperature continuous extraction method are adopted for separation, and low-temperature extraction is adopted, so that the effective components are not damaged. The supercritical extraction is to make the solvent and the extract fully contact and replace in an extraction cylinder under the condition of simulating proper pressure and temperature, the solute is diffused into the solvent, and the dissolved substance is precipitated by changing the operation in a separator and simulating the environment to achieve the final purpose of separation. The supercritical fluid is fluid with thermodynamic state over critical point (Pc, Tc), the critical point is the state point where the gas-liquid interface just disappears, the supercritical fluid has very unique physical and chemical properties, its density is close to liquid, viscosity is close to gas, and its diffusion coefficient is large, viscosity is small, dielectric constant is large, etc., so that it has good separation effect, and is a good solvent.
When the supercritical extraction method is adopted to extract the concentrated solution of the plant protoplasm, the critical temperature is lower, the method is suitable for extracting and purifying heat-sensitive compounds, an inert environment can be provided, the oxidation of products is avoided, and the effective ingredients of the extract are not influenced. The extraction speed is high, no solvent residue is left, nitrate and heavy metal ions are avoided, and the activity of effective components is ensured.
The concentrated solution of the plant raw pulp is extracted by adopting an efficient high-pressure-difference low-temperature continuous extraction and separation technology (HH L SE), and the concentrated solution is extracted and refined, can remove various pollutants such as pesticides, heavy metals and the like, is not added with any chemical raw materials such as preservatives, essence and the like, is quickly absorbed, and is efficient and convenient.
The extraction principle is as follows: mixing herbaceous raw materials with certain fineness with selected solvent at certain process temperature, generating strong mechanical force and forming high-speed flow by using high pressure difference change (-0.1-60 MPa) of approximate 'instant' (0.1-0.2 s) to crack the extracted plants, and simultaneously, fully contacting and dissolving the contained chemical components with the solvent under high pressure to achieve the effect of high-efficiency extraction; continuous 'instant' forms macroscopic continuity, and is organically combined with membrane separation and concentration to form a continuous production process of extraction, membrane separation and concentration.
The multi-stage membrane concentration technology avoids the problem that the extract is thermally molten and condensed on one hand, realizes the recycling of the solvent on the other hand, really realizes the O discharge column chromatography separation technology which is mainly used for optimizing the multi-stage membrane separation technology and further purifying the content of specific components and mainly aims at products with high requirements on the content of one or more effective components, and the high-efficiency high-pressure-difference low-temperature continuous extraction and separation concentration technology (HH L SE) is one of the currently globally advanced extraction technologies, adopts a physical mode in the whole process of extraction and is carried out in a low-temperature state, thereby realizing the maximum retention rate of the original substance.
The invention has the beneficial effects that: compared with the prior art, the technical scheme provided by the invention has the advantages that the components are scientifically matched and reasonably formulated, and the active substances capable of promoting the metabolism of cutin can be obtained; anti-inflammatory substances capable of rapidly killing skin parasitic flora such as propionibacterium acnes and mites; and active substances which provide moisture and nutrient components for the skin, keep the skin balanced and moist but not greasy, and repair the damaged skin.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
An acne-removing essence containing a Chinese herbal medicine composition is prepared from the following raw materials in percentage by weight: 3% of pouzolzia extract, 5% of cotton rose hibiscus extract, 8% of trichosanthes root extract, 5% of spina gleditsiae extract, 5% of aloe extract, 5% of dandelion extract, 16% of eucalyptus leaf extract and the balance of water.
The preparation method comprises the following steps: mixing the raw materials in proportion, heating to 60-80 ℃, uniformly stirring, cooling and filtering to obtain the acne-removing essence finished product.
Example 2
An acne-removing essence containing a Chinese herbal medicine composition is prepared from the following raw materials in percentage by weight: 5% of pouzolzia extract, 8% of cotton rose hibiscus extract, 10% of trichosanthes root extract, 8% of spina gleditsiae extract, 8% of aloe extract, 10% of dandelion extract, 20% of eucalyptus leaf extract, 1% of rhubarb extract and the balance of water.
The preparation method is the same as that of example 1.
Example 3
An acne-removing essence containing a Chinese herbal medicine composition is prepared from the following raw materials in percentage by weight: 8% of water hyacinth extractive, 10% of cotton rose hibiscus extractive, 12% of trichosanthes root extractive, 10% of Chinese honeylocust spine extractive, 10% of aloe extractive, 15% of dandelion extractive, 24% of eucalyptus leaf extractive, 2% of rhubarb extractive and the balance of water.
The preparation method is the same as that of example 1.
Example 4
An acne-removing essence containing a Chinese herbal medicine composition is prepared from the following raw materials in percentage by weight: 5% of pouzolzia extract, 8% of cotton rose hibiscus extract, 10% of trichosanthes root extract, 8% of spina gleditsiae extract, 8% of aloe extract, 12% of dandelion extract, 22% of eucalyptus leaf extract, 4% of rhubarb extract and the balance of water.
The preparation method is the same as that of example 1.
In order to verify the acne removing efficacy of the efficacy combination, a series of experimental tests are carried out, which mainly comprise the following steps: 1. and (4) an efficacy test is carried out to investigate the bacteriostatic and bactericidal capacity of the composition.
Test method
The method comprises the steps of preparing a propionibacterium acnes (ATCC11827) plate by a double-layer plate method, accurately weighing 0.5g of sample, uniformly coating a sterile cotton swab on the plate containing bacteria, culturing for 24 hours at 36 +/-1 ℃ under an anaerobic condition, and observing the growth result of bacterial colonies in the plate, wherein the bacterial content of the plate is 104-105 CFU/plate.
Determination of results
1) Bacterial colony growth is not found (the sample has stronger inhibition effect on propionibacterium acnes and good acne removing effect); 2) partial bacterial colony growth (showing that the sample has a certain inhibition effect on propionibacterium acnes and the sample has an anti-acne effect); 3) the colonies grew completely (indicating that the sample had no inhibitory effect on propionibacterium acnes, and that the sample had no anti-acne effect).
The antibacterial effect test result shows that no bacterial colony grows in the plate, and the acne removing essence has a good antibacterial effect and is beneficial to the realization of the acne removing effect of cosmetics. In order to eliminate the influence of the preservative on the bacteriostatic effect, the preservative is not added to the samples subjected to the efficacy test.
2. Human test for acne
Test method
The acne removing effect test is respectively carried out on the acne removing essence liquid of the embodiment 1-4, the experimental group subjects are 16-30 years old, the average age is 22 years old, 40 papules, pustules and pockmarks are arranged on the face, and the experimental group subjects are divided into four groups, wherein each group contains 10 acne removing essences; 1 control group subject with age of 16-30 years, average 22 years, 10 papules, pustules and pocks on face, and recorded skin lesion count before treatment;
the subjects in the experimental group were each applied with the acne removing essence of examples 1 to 4 every night, the subjects in the control group were applied with the conventional acne removing mask every night for 4 weeks, the post-treatment skin lesion count was counted every 1 week, and the treatment rate (pre-treatment skin lesion count-post-treatment skin lesion count)/pre-treatment skin lesion count was calculated by × 100% according to the following formula, to obtain the experimental results of the following table:
| item | Example 1 | Example 2 | Example 3 | Example 4 | Control group |
| First week | 26％ | 30％ | 38％ | 42％ | 15％ |
| Second week | 40％ | 46％ | 55％ | 58％ | 22％ |
| The third week | 55％ | 64％ | 76％ | 79％ | 30％ |
| The fourth side | 77％ | 80％ | 87％ | 89％ | 43％ |
The test result of the acne removing effect of the human body of the patient shows that the treatment rate of the patient adopting the traditional Chinese medicine acne removing essence is up to more than 77 percent, but the treatment rate of the patient adopting the traditional Chinese medicine acne removing essence is only about 43 percent, so that the acne removing essence disclosed by the invention has a good acne removing effect.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (6)
1. The acne-removing essence containing the Chinese herbal medicine composition is characterized by being prepared from the following raw materials in percentage by weight: 3-8% of Yushui kudzu root extract, 5-10% of cotton rose hibiscus extract, 8-12% of trichosanthes root extract, 5-10% of spina gleditsiae extract, 5-10% of aloe extract, 5-15% of dandelion extract, 16-24% of eucalyptus leaf extract and the balance of water.
2. The acne-removing essence containing a Chinese herbal medicine composition according to claim 1, further comprising 1-4% of rhubarb extract.
3. The preparation method of the acne-removing essence containing the Chinese herbal medicine composition as claimed in claim 1 or 2, wherein the finished product of the acne-removing essence is obtained by mixing the raw materials in proportion, heating to 60-80 ℃, uniformly stirring, cooling and filtering.
4. The acne-removing essence containing a Chinese herbal medicine composition as claimed in claim 1 or 2, wherein the aloe extract is prepared by the following steps: peeling fresh aloe, cutting, placing in clean and sterilized cloth bag, squeezing to obtain aloe juice, and filtering with 80 mesh nylon gauze to obtain aloe extract.
5. The acne-removing essence containing a Chinese herbal medicine composition as claimed in claim 1 or 2, wherein the eucalyptus leaf extract is prepared by the following steps: weighing folium Eucalypti Globueli, placing in a flask, adding water 2-3 times of folium Eucalypti Globueli, soaking for 0.3-1 hr, and distilling in 100 deg.C water bath for 0.8-1.2 hr to obtain distilled fluid extract.
6. The essence containing Chinese herbal medicine composition for removing acne according to claim 2, wherein the extraction method of the pouzolzia extract, the cotton rose hibiscus extract, the trichosanthes root extract, the spina gleditsiae extract, the dandelion extract and the rheum officinale extract is any one of high pressure difference low temperature continuous extraction separation and concentration technology or supercritical extraction.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112044113A (en) * | 2020-08-26 | 2020-12-08 | 耒阳市刘燕酿制生物科技有限公司 | Essence preparation facilities that contains aloe leaf extract product |
| CN115869197A (en) * | 2022-10-27 | 2023-03-31 | 双飞人制药股份有限公司 | Bacteriostatic itching-relieving agent |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688811A (en) * | 2014-12-29 | 2015-06-10 | 昆明皕凯科技有限公司 | Acne removal composition based on natural plant raw materials and application thereof |
| CN104826004A (en) * | 2015-04-28 | 2015-08-12 | 余国安 | Acne and speckle eliminating drug and preparation method thereof |
| CN105326730A (en) * | 2015-12-16 | 2016-02-17 | 广州市中通生化制品有限公司 | Acne-removing composition containing Chinese herb extracts and preparation method thereof |
| CN106361661A (en) * | 2016-10-19 | 2017-02-01 | 刘艺鹏 | Natural traditional Chinese medicine skin-protecting lotion |
| CN106729239A (en) * | 2016-12-26 | 2017-05-31 | 广西民族大学 | A kind of anti-acne ointment |
| CN107184511A (en) * | 2017-05-17 | 2017-09-22 | 宁波烯谷科技有限公司 | A kind of active external application Essence with anti-inflammatory, promotion skin reparative regeneration and white-skinned face function and preparation method thereof |
| CN107320363A (en) * | 2017-06-01 | 2017-11-07 | 佛山市汇汾化妆品科技有限公司 | A kind of anti-acne essence |
-
2020
- 2020-03-25 CN CN202010216472.6A patent/CN111388384A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688811A (en) * | 2014-12-29 | 2015-06-10 | 昆明皕凯科技有限公司 | Acne removal composition based on natural plant raw materials and application thereof |
| CN104826004A (en) * | 2015-04-28 | 2015-08-12 | 余国安 | Acne and speckle eliminating drug and preparation method thereof |
| CN105326730A (en) * | 2015-12-16 | 2016-02-17 | 广州市中通生化制品有限公司 | Acne-removing composition containing Chinese herb extracts and preparation method thereof |
| CN106361661A (en) * | 2016-10-19 | 2017-02-01 | 刘艺鹏 | Natural traditional Chinese medicine skin-protecting lotion |
| CN106729239A (en) * | 2016-12-26 | 2017-05-31 | 广西民族大学 | A kind of anti-acne ointment |
| CN107184511A (en) * | 2017-05-17 | 2017-09-22 | 宁波烯谷科技有限公司 | A kind of active external application Essence with anti-inflammatory, promotion skin reparative regeneration and white-skinned face function and preparation method thereof |
| CN107320363A (en) * | 2017-06-01 | 2017-11-07 | 佛山市汇汾化妆品科技有限公司 | A kind of anti-acne essence |
Non-Patent Citations (3)
| Title |
|---|
| 李萃邦等: "桉树叶活性成分提取方法及生物活性研究进展", 《湖北农业科学》 * |
| 杨柳等: "不同助溶剂作用下桉叶油对痤疮丙酸杆菌的作用", 《湖南中医药大学学报》 * |
| 陈艳芬等: "多枝雾水葛对大鼠皮肤溃疡的作用及机制研究", 《中药新药与临床药理》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112044113A (en) * | 2020-08-26 | 2020-12-08 | 耒阳市刘燕酿制生物科技有限公司 | Essence preparation facilities that contains aloe leaf extract product |
| CN115869197A (en) * | 2022-10-27 | 2023-03-31 | 双飞人制药股份有限公司 | Bacteriostatic itching-relieving agent |
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