CN107184511A - A kind of active external application Essence with anti-inflammatory, promotion skin reparative regeneration and white-skinned face function and preparation method thereof - Google Patents
A kind of active external application Essence with anti-inflammatory, promotion skin reparative regeneration and white-skinned face function and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention discloses a kind of with anti-inflammatory, the active external application Essence for promoting skin reparative regeneration and white-skinned face function and preparation method thereof.Contain natural plant extracts composition in the cosmetic formulations of the present invention, described plant extracts is made up of Caulis Akebiae extract, Angelica Dahurica extract, Flos Sophorae extract, Radix Trichosanthis extract, Polygonum multiflower knotweed extract, Gentrin Knotweed P.E, Herba Selaginellae Involventis extract, aloe extract and mint extract.Experiment confirms that product of the present invention is non-stimulated to skin safe, with significant anti-inflammatory, promotes skin reparative regeneration and whitening effect, and then can reach the purpose for the treatment of acne.Raw material of the present invention are obtained easy, preparation method simplicity, green safety, with good application prospect and market prospects.
Description
Technical field
It is more particularly to a kind of that there is anti-inflammatory, promote flesh the present invention relates to a kind of active external application Essence and preparation method thereof
Active external application Essence of skin reparative regeneration and white-skinned face function and preparation method thereof.The invention belongs to cosmetic technical field.
Background technology
Acne also known as youth disease acne, dark sore or acne, are a kind of chronic inflammatory skins of pilosebaceous unit, main
It is apt to occur in teenager.With the characteristics of the polymorphy skin damageds such as acne, papule, warts, tubercle of the clinical manifestation to be apt to occur in face.
The generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.The level of androgen particularly testosterone in descendant's body that adolesces is raised rapidly, promotes sebaceous glands development
And produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, and dyssebacia forms cutin
Bolt is micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase that propionibacterium acnes is produced
Sebum generation free fatty is decomposed, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.
At present, chemical bactericide, hormone, astringent, antiinflammatory etc. be with the addition of the cosmetics of in the market treatment acne more, though
It can sterilize or diminish inflammation in a short time, but it is big to skin irritation, and long-term use can increase skin burden, and easily cause skin
The allergic symptoms such as skin redness, suppuration or pain, and because pathogen easily produces drug resistance, youth disease can recur quickly, easily
Form insane trace or pigmentation.
In recent years, plant extracts as skin care item additive, with green safety, efficacy stability be lasting, curative effect is aobvious
Write and to advantages such as skin action temperatures, obtain the favor and accreditation of consumers in general.
In consideration of it, the present invention is proposed outside a kind of activity for having anti-inflammatory, promotion skin reparative regeneration and white-skinned face function concurrently
Essence and preparation method thereof is applied, its one side can reduce the symptoms such as red swelling of the skin, suppuration or the pain caused by acne, separately
On the one hand skin reparative regeneration can also be promoted, the problems such as greatly reducing the scar and pigmentation after acne healing.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of with anti-inflammatory, promotion skin reparative regeneration and whitening work(
Active external application Essence of effect and preparation method thereof.
In order to achieve the above object, present invention employs following technological means：
A kind of active external application Essence with anti-inflammatory, promotion skin reparative regeneration and white-skinned face function of the present invention, its
By A phase, B phase, C phase, D phases and E phase compositions；
Wherein, the A phases are by stearine, dimethyl silicone polymer, isononyl isononanoate, jojoba oil, Mo Luo
Brother Ah glycerine, fine jade precipice Malus spectabilis oil, isopropyl myristate, octyl stearate, linoleic acid and caprylic/capric triglyceride group
Into；
The B phases are made up of xanthans, propane diols, butanediol, trehalose, L- pyrrolidones carboxylic sodium and water；
The C phases are rilanit special, Va palmitates, Ve acetates and hyaluronic acid composition；
The D phases are made up of plant extracts, niacinamide and preservative：Described plant extracts is by following parts by weight
Each raw material composition：Caulis Akebiae extract 20-40 parts by weight, Angelica Dahurica extract 15-25 parts by weight, Flos Sophorae extract 10-20 weight
Part, Radix Trichosanthis extract 10-20 parts by weight, Polygonum multiflower knotweed extract 10-20 parts by weight, Gentrin Knotweed P.E 15-25 parts by weight, the south of the River
Spikemoss extract 15-25 parts by weight, aloe extract 10-20 parts by weight and mint extract 5-10 parts by weight composition；
The E phases are made up of pH adjusting agent, regulation preparation pH=6.0.
In the present invention, it is preferred to, described plant extracts is made up of each raw material of following parts by weight：Caulis Akebiae extract
30 parts by weight, the parts by weight of Angelica Dahurica extract 20, the parts by weight of Flos Sophorae extract 15, the parts by weight of Radix Trichosanthis extract 15, Polygonum multiflower knotweed carry
Take the parts by weight of thing 15, the parts by weight of Gentrin Knotweed P.E 20, the parts by weight of Herba Selaginellae Involventis extract 20, the parts by weight of aloe extract 15 and
The parts by weight of mint extract 8 are constituted.
In the present invention, it is preferred to, described hyaluronic acid is the big of 1 800 000~2 200 000Da by molecular weight
The middle-molecular-weihydroxyethyl hyaluronic acid and molecular weight that molecular weight hyaluronic acid, molecular weight are 1 000 000~1 800 000Da be
400 000~1 000 000Da macromolecule hyaluronic acid is 1 according to weight ratio:1:1 mixes.
In the present invention, it is preferred to, each raw material weight percent shared in the active external application Essence (in addition to E phases)
Than being respectively：Stearine 1.5~6.0%, dimethyl silicone polymer 0.1~4.0%, isononyl isononanoate 0.1~
3.0%th, jojoba oil 0.5~3.0%, Morocco's Ah's glycerine 0.5~3.0%, fine jade precipice Malus spectabilis oil 3~5.0%, myristic acid are different
Propyl ester 0.5~3.0%, octyl stearate 0.5~5.0%, linoleic acid 0.1~3.0%, caprylic/capric triglyceride 1.0~
5.0%th, xanthans 0.05~0.2%, propane diols 1~3.0%, butanediol 0.1~3.0%, trehalose 0.05-1.0%, L- pyrrole
Pyrrolidone carboxylic sodium 0.5~2.0%, rilanit special 0.5-3.0%, Va palmitate 0.05~1%, Ve acetates 0.05~
0.5%th, hyaluronic acid 0.05~0.5%, plant extracts 0.5-5.0%, niacinamide 0.1~2%, preservative 0.05~
0.2%, surplus is water.It is furthermore preferred that each raw material percentage by weight shared in the active external application Essence (in addition to E phases)
Respectively：Stearine 3.5%, dimethyl silicone polymer 2.0%, isononyl isononanoate 1.5%, jojoba oil 1.5%,
Morocco's Ah's glycerine 1.5%, fine jade precipice Malus spectabilis oil 4.0%, isopropyl myristate 1.5%, octyl stearate 2.5%, linoleic acid
1.5%th, caprylic/capric triglyceride 2.0%, xanthans 0.1%, propane diols 2.0%, butanediol 1.5%, trehalose 0.5%,
L- pyrrolidones carboxylics sodium 1.0%, rilanit special 1.5%, Va palmitates 0.5%, Ve acetates 0.1%, hyaluronic acid
0.3%th, plant extracts 5.0%, niacinamide 2.0%, preservative 0.1%, surplus is water.
In the present invention, it is preferred to, the preservative is in Phenoxyethanol, pungent glycol, quaternary ammonium salt -15 and dehydroacetic acid
One or more.
In the present invention, it is preferred to, described Caulis Akebiae extract, Angelica Dahurica extract, Flos Sophorae extract, root of Chinese trichosanthes are extracted
Thing, Polygonum multiflower knotweed extract, Gentrin Knotweed P.E, Herba Selaginellae Involventis extract, aloe extract and mint extract respectively according to
Lower section method is prepared：
(1) by plant material clean, dry, crush after, and cross 20 mesh sieves；
(2) powder after sieving is carried out into backflow at 75~85 DEG C with the ethanol that percent by volume is 60%~95% to carry
Take, bulk drug is 1~3 with ethanol mass volume ratio g/mL:10~50, refluxing extraction 3-5h, carry out 3-4 times, then will carry altogether
Liquid is taken to merge；Residual residue carries out extraction 2-3 times using hot water, and each 3-5h merges extract solution with the extract solution of step (2)
After be cooled to 20 DEG C~30 DEG C, 50~100 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) and the 1,3-BDO of ethanol same volume accumulated amount is miscible uniform, decompression
The ethanol in solution is concentrated out, then vacuum decompression suction filtration, filtrate produces through activated carbon decolorizing, freeze-drying；
(5) Caulis Akebiae extract, Angelica Dahurica extract, Flos Sophorae extract, the root of Chinese trichosanthes that will be obtained according to step (1)-(4) are extracted
Thing, Polygonum multiflower knotweed extract, Gentrin Knotweed P.E, Herba Selaginellae Involventis extract, aloe extract and mint extract are according to described
Well mixed parts by weight are described plant extracts.
Further, the invention also provides a kind of method for preparing the active external application Essence, comprise the following steps：
(1) following raw material is weighed according to described percentage by weight：It is stearine, dimethyl silicone polymer, different
The different nonyl ester of n-nonanoic acid, jojoba oil, Morocco's Ah's glycerine, fine jade precipice Malus spectabilis oil, isopropyl myristate, octyl stearate, linoleic acid,
Caprylic/capric triglyceride, xanthans, propane diols, butanediol, trehalose, L- pyrrolidones carboxylics sodium, rilanit special, Va palm fibres
Glycerin monostearate, Ve acetates, hyaluronic acid and plant extracts；
(2) by stearine, dimethyl silicone polymer, isononyl isononanoate, jojoba oil, Morocco's Ah's glycerine,
After fine jade precipice Malus spectabilis oil, isopropyl myristate, octyl stearate, linoleic acid and caprylic/capric triglyceride mixing, it is heated to
80~85 DEG C, mix, obtain A phases；
(3) after the water of xanthans, propane diols, butanediol, trehalose, L- pyrrolidones carboxylic sodium and 2/3 volume is mixed,
80~85 DEG C are heated to, mixing obtains B phases；
(4) A phases are all added in B phases, 2000~3000r/min, homogeneous 5min~10min；Sequentially add hydrogenation
Castor oil, Va palmitates, Ve acetates and hyaluronic acid, 2000~3000r/min, 1~3min of homogeneous；30~50r/
After min, 5~10min of stirring, start stirring cooling, stir speed (S.S.) is 30~50r/min, and rate of temperature fall is 1~2 DEG C/min；
(5) water of remaining 1/3 volume is added into plant extracts, after dissolving completely, temperature is added and drops to 45~50
DEG C the step of (4) obtained mixture in, add niacinamide and preservative, stir, continue to be cooled to less than 40 DEG C；
(6) preparation pH=6.0 is adjusted using pH adjusting agent, produced.
Compared to prior art, the beneficial effects of the present invention are：
1st, inventor understanding thoroughly the etiology and pathology of acne, it is dialectical careful because on the basis of, selected from numerous bulk drugs
Select Caulis Akebiae extract, Angelica Dahurica extract, Flos Sophorae extract, Radix Trichosanthis extract, Polygonum multiflower knotweed extract, Gentrin Knotweed P.E, the south of the River
Spikemoss extract, aloe extract and mint extract are as bulk drug, according to the principles of formulating prescriptions, decide consumption, specify monarch,
Minister, the different status helped, made and its mutual compatibility relationship, make it play its comprehensive function, restrict its unfavorable factor, be allowed to medication
Suitably, compatibility is rigorous, makes a distinction between the important and the lesser one, proper combination of syndromes feelings, without real, and asthenia syndrome detesting purgation achieves good therapeutic effect.Particularly akebi
The not expected curative effect for improving original medicine of addition of extract so that effect of this product is greatly increased；
2nd, the present invention adds fine jade precipice Malus spectabilis oil in formula, and fine jade precipice Malus spectabilis oil is a kind of outstanding external application consolidant, can
To help to recover skin health, anti-inflammatory, anti-infective, antibacterial and anti-oxidant can speed up skin histology growth, promote new epidermis
Formed.But fine jade precipice Malus spectabilis is oily itself to have the taste for nose of choking, but coordinates the plant extracts of the present invention to use, and plant extracts is certainly
The delicate fragrance of band has reconciled the taste of this nose of choking so that this product is on the basis of without any artificial essence, with light
Flowers and plants fragrance；
3rd, research is found, in the reason for causing acne, water shortage is a key point, because skin water shortage can be stimulated naturally
Pore discharges grease, causes pore obstruction to cause acne.Therefore, the present invention has added the hyalomitome of different molecular weight in formula
Acid.The ability that the hyaluronic acid of different molecular weight penetrates into skin is different, and the effect brought is also different, and macromolecule is transparent
Matter acid, which has, prevents dehydration, and histocyte regeneration, the effect for the skin that compacts, middle-molecular-weihydroxyethyl hyaluronic acid has the skin that compacts, made
The effect of the permanent moisturizing of skin, small-molecular-weight hyaluronic acid has quickly occurs aquation with cell, keeps cell moisture
Effect.The present invention improves the moisturizing that product has, water conservation work(using the hyaluronic acid of three kinds of molecular weight is used cooperatively
Effect.
4th, in order to improve the whitening effect of product, the present invention adds niacinamide in formula, and niacinamide is few tool
There is the full effect skin care ingredient of moisturizing whitening anti-wrinkling anti-acne, but niacinamide can be hydrolyzed to skin in pH value is not for 6 aqueous solution
Strong nicotinic acid is stimulated, so the present invention adjusts preparation pH=6.0 using pH adjusting agent, the hydrolysis of niacinamide is greatly reduced, and
And strictly control consumption, it is ensured that its security to skin；
5th, experiment confirms that product of the present invention is non-stimulated to skin safe, with significant anti-inflammatory, promotes skin reparative regeneration
And whitening effect, and then the purpose for the treatment of acne can be reached.Easy, preparation method simplicity that raw material of the present invention are obtained,
Green safety, with good application prospect and market prospects.
Embodiment
Following examples are that the present invention is further illustrated, should not be understood as limitation of the present invention.
The preparation of the plant extracts of embodiment 1
(1) respectively by akebi stem rattan, the root of Dahurain angelica, sophora flower, root of Chinese trichosanthes, Polygonum multiflower knotweed, giant knotweed, selaginella tamariscina, aloe and peppermint
This nine kinds of plant materials clean, dry, crush after, cross 20 mesh sieves, obtained powder carried according to step (2)-(4) respectively
Take；
(2) refluxing extraction, bulk drug and ethanol quality volume are carried out at 80 DEG C for 90% ethanol with percent by volume
It is 1 than g/mL:20, refluxing extraction 4h, carry out 4 times, then merge extract solution altogether；
(3) residual residue carries out extraction 3 times, each 4h, after extract solution is merged with the extract solution of step (2) using hot water
20 DEG C~30 DEG C are cooled to, 100 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) and the 1,3-BDO of ethanol same volume accumulated amount is miscible uniform, decompression
The ethanol in solution is concentrated out, then vacuum decompression suction filtration, collect filtrate, filtrate obtains wood through activated carbon decolorizing, freeze-drying
Logical extract, Angelica Dahurica extract, Flos Sophorae extract, Radix Trichosanthis extract, Polygonum multiflower knotweed extract, Gentrin Knotweed P.E, selaginella tamariscina
Extract, aloe extract and mint extract；
(5) obtained Caulis Akebiae extract, Angelica Dahurica extract, Flos Sophorae extract, Radix Trichosanthis extract, Polygonum multiflower knotweed are extracted
Thing, Gentrin Knotweed P.E, Herba Selaginellae Involventis extract, aloe extract and mint extract are mixed by following weight, i.e.,
For described plant extracts：
The parts by weight of Caulis Akebiae extract 30, the parts by weight of Angelica Dahurica extract 20, the parts by weight of Flos Sophorae extract 15, Radix Trichosanthis extract
15 parts by weight, the parts by weight of Polygonum multiflower knotweed extract 15, the parts by weight of Gentrin Knotweed P.E 20, the parts by weight of Herba Selaginellae Involventis extract 20, aloe
The parts by weight of extract 15 and the parts by weight of mint extract 8.
Embodiment 2 has anti-inflammatory, promotes the active external application Essence of skin reparative regeneration and white-skinned face function
1st, it is formulated
Count by weight percentage, stearine 3.5%, dimethyl silicone polymer 2.0%, isononyl isononanoate
1.5%th, jojoba oil 1.5%, Morocco's Ah's glycerine 1.5%, fine jade precipice Malus spectabilis oil 4.0%, isopropyl myristate 1.5%, hard
Resin acid monooctyl ester 2.5%, linoleic acid 1.5%, caprylic/capric triglyceride 2.0%, xanthans 0.1%, propane diols 2.0%, fourth two
Alcohol 1.5%, trehalose 0.5%, L- pyrrolidones carboxylics sodium 1.0%, rilanit special 1.5%, Va palmitates 0.5%, Ve vinegar
Plant extracts 5.0% that acid esters 0.1%, hyaluronic acid 0.3%, embodiment 1 are prepared, niacinamide 2.0%, preservative
(Phenoxyethanol) 0.1%, water supplies 100%.
Described hyaluronic acid is by macromolecule hyaluronic acid, molecule of the molecular weight for 1 800 000~2 200 000Da
The middle-molecular-weihydroxyethyl hyaluronic acid and molecular weight that amount is 1 000 000~1 800 000Da are 400 000~1 000 000Da
Macromolecule hyaluronic acid according to weight ratio be 1:1:1 mixes.
2nd, method
(1) by stearine, dimethyl silicone polymer, isononyl isononanoate, jojoba oil, Morocco's Ah's glycerine,
After fine jade precipice Malus spectabilis oil, isopropyl myristate, octyl stearate, linoleic acid and caprylic/capric triglyceride mixing, it is heated to
80 DEG C, mix, obtain A phases；
(3) after mixing xanthans, propane diols, butanediol, trehalose, L- pyrrolidones carboxylic sodium and water, 80 are heated to
DEG C, mix, obtain B phases；
(4) A phases are all added in B phases, 2000r/min, homogeneous 10min；Sequentially add rilanit special, Va palms
Acid esters, Ve acetates and hyaluronic acid, 2000r/min, homogeneous 3min；After 50r/min, stirring 10min, start stirring drop
Temperature, stir speed (S.S.) is 50r/min, and rate of temperature fall is 2 DEG C/min；
(5) water of remaining 1/3 volume is added into plant extracts, after dissolving completely, temperature is added and drops to 45 DEG C
In the mixture that step (4) is obtained, niacinamide and Phenoxyethanol are added, is stirred, continue to be cooled to less than 40 DEG C；
(6) using pH adjusting agent (NaOH solution) regulation preparation pH=6.0, produce.
Comparative example 1
Differing only in formula for comparative example 1 is added without Caulis Akebiae extract.
Comparative example 2
Differing only in formula for comparative example 1 is added without plant extracts.
The anti-inflammatory activity evaluation of plant extracts part in the product of the present invention of experimental example 1
Hyaluronidase and trypsase are inflammation generation and the important enzyme material in evolution, reduce or suppress this
The activity of two kinds of enzymes is the effective way for preventing inflammation from occurring, and the present embodiment is by studying product of the present invention for hyaluronidase
Inhibition illustrate the anti-inflammatory effect of plant extracts part in product of the present invention.
Experimental group I：Plant extracts I, is prepared according to the method for embodiment 1
Experimental group II：Plant extracts II, is prepared according to the method for embodiment 1, and difference is not containing Caulis Akebiae extract
Experimental group II：Caulis Akebiae extract, is prepared according to the method for embodiment 1
Above plant extracts adds 10 times of weight distilled water and dissolved, and being configured to solution is used for following experiment.
Hyaluronidase body outer suppressioning experiment is carried out using Elson-Morgan methods：Take 0.1mL 0.25mmol/LCaCl2
37 DEG C of heat insulating culture 20min of solution and 0.5mL hyaluronic acids enzyme liquid；It is separately added into experimental group I, experimental group II and experimental group
III plant extracts 0.5mL, 1ml and 1.5ml, continues 37 DEG C of heat insulating culture 20min；Add 0.5mL 1250ug/mL's
Sodium Hyaluronate liquid 37 DEG C of insulations 30min, room temperature 5min；Add 0.1mL0.4mol/L NaOH solutions and 0.5mL acetyl
Acetone soln, is placed in after heating 15min in boiling water bath and carries out cooling 5min with frozen water immediately；Add Ehrlich's reagent 1.0mL
And be diluted with 3.0mL absolute ethyl alcohols, 20min colour developings are placed, with its absorbance of spectrophotometric determination, with acetate buffer
Solution is used as contrast solution.
Calculation formula：
In formula：A --- contrast solution ABS values
B --- control blank solution ABS values
C --- sample solution ABS values
D --- sample blank solution A BS values
Experimental group I-11I groups are shown in Table 1 to hyaluronic acid enzyme inhibition in vitro, as shown in Table 1, experimental group I and experiment
Group II plant extracts is respectively provided with significant inhibitory action, but experimental group I hyaluronic acid enzyme inhibition rate to hyaluronidase
It is significantly higher than experimental group II, and the group inhibiting rate for adding Caulis Akebiae extract merely is relatively low, this illustrates Caulis Akebiae extract
Have with other components and cooperate with facilitation, so as to improve the anti-inflammatory effect of plant composition.
The hyaluronic acid enzyme inhibition rate of table 1
The suppression tyrosinase activity of plant extracts part is evaluated in the product of the present invention of experimental example 2
1st, material：Tyrosinase, TYR, disodium hydrogen phosphate, sodium dihydrogen phosphate thermostat, ultraviolet specrophotometer,
Centrifuge.
Experimental group I：Plant extracts is prepared according to the method for embodiment 1
Experimental group II：Plant extracts is prepared according to the method for embodiment 1, and difference is not containing Caulis Akebiae extract.
Experimental group III：Caulis Akebiae extract, is prepared according to the method for embodiment 1
Above plant extracts adds 10 times of weight distilled water and dissolved, and being configured to solution is used for following experiment.
2 preparation of reagents：
1) sodium phosphate buffer (1/15mol/L, pH=6.8)：Accurately weigh 1.000g sodium dihydrogen phosphates, 1.186g phosphoric acid
Disodium hydrogen, adds after a small amount of deionized water dissolving, is settled to 500mL, 4 DEG C of refrigerators are saved backup.
2) TYR solution (7.5mmol/L)：TYR 0.272g accurately is weighed, few drops of concentrated hydrochloric acids are first added, plus
Deionized water about 50mL, after low-grade fever is completely dissolved, adjusts pH to 7 or so, plus deionized water to be settled to sodium hydroxide solution
200mL。
3rd, detection method
Overall reaction system is 5mL.During experiment, sequentially added into test tube sodium phosphate buffer, different volumes by test solution,
Enzyme liquid, in 30 DEG C of water-bath 10min.Then substrate TYR is added, timing is immediately begun to.475nm ripples when determining reaction 20min
Light absorption value under long.During measure, using corresponding negative control as reference, experiment with computing group I-III is distinguished to junket with following equation
The inhibiting rate of propylhomoserin enzyme, and according to the approximation of concentration-enzyme inhibition rate curve estimation half-inhibition concentration (IC50).
Inhibiting rate=[(A-B)/A] × l00%
Wherein, " A " is the light absorption value of standard control, and " B " is the light absorption value by test solution.Each experiment do 3 it is parallel.Suppress
Rate height shows its inhibition strength height to tyrosinase activity.
4th, result
Experimental group I-III is shown in Table 2 to tyrosinase In-vitro Inhibitory Effect, as shown in Table 2, experimental group I and experimental group II
Plant extracts certain inhibitory action is respectively provided with to tyrosinase, but experimental group I hyaluronic acid enzyme inhibition rate is a little higher than
Experimental group II, and the group inhibiting rate for adding Caulis Akebiae extract merely is relatively low, this illustrates Caulis Akebiae extract and other groups
Dividing has certain collaboration facilitation, so as to improve effect that plant composition suppresses tyrosinase.
The tyrosinase inhibition rate of table 2
Inhibition of the plant extracts part to propionibacterium acnes in the product of the present invention of experimental example 3
1st, tested strain
Propionibacterium acnes freeze-drying lactobacillus ATCC 11827.
2nd, for examination culture medium
10% sheep blood and 2% agar are added in improvement GAM broth bouillons, is dissolved by heating, 115 DEG C of autoclaving 15min,
It is poured in flat board culture dish, the recovery flat board and slant medium of freeze-dried vaccine is used as with this.
3rd, the preparation of bacteria suspension
Lyophilized bacterial strain is seeded in flat board using plate streak, after 37 DEG C of Anaerobic culturel 72h, the single growth of picking
Bacterium colony, is seeded to improvement GAM broth bouillons, continues to cultivate 24h, as bacteria suspension.
4th, subject material：
Experimental group I：Plant extracts is prepared according to the method for embodiment 1
Experimental group II：Plant extracts is prepared according to the method for embodiment 1, and difference is not containing Caulis Akebiae extract.
Experimental group III：Caulis Akebiae extract, is prepared according to the method for embodiment 1
Above plant extracts adds 10 times of weight distilled water and dissolved, and being configured to solution is used for following experiment.
5th, bacteriostatic experiment specific steps：
Using disc diffusion method, carried out under aseptic condition, filter paper is broken into diameter 6mm circular filter paper with card punch
Piece, is placed in after clean clean small beaker, 115 DEG C of hot air sterilization 20min, is respectively put into the sample for the experimental group I-III that sterilized
Fully soaked in liquid, 8 filter papers are put into every kind of sample liquid.It will prepare and melted for examination culture medium, training is poured into respectively
Support in ware, 115 DEG C of sterilizing 20min, after solidification to be cooled, draw 0.1ml bacteria suspensions uniform in being coated with flat board.Use aseptic nipper
The a diameter of 6mm circular filter paper pieces soaked in sample liquid is put forward are gripped respectively, are attached on flat board containing bacterium, in each flat board etc.
Distance patch 4, is placed in 37 DEG C of constant incubator middle plateforms by each culture dish and is inverted culture 24h, determine the size of antibacterial circle diameter,
If 3 repetitions, take its average value.As a result it is as shown in table 3.
The different sample liquids of table 3 compare the fungistatic effect of propionibacterium acnes
| Experimental group | Average antibacterial circle diameter (mm) |
| Experimental group I | 28.5 |
| Experimental group II | 17.0 |
| Experimental group III | 21.5 |
From table 3 it can be seen that compared with fungistatic effects of the experimental group II and experimental group III to propionibacterium acnes, it is real
Plant extracts obtained by group I is tested to the fungistatic effect of propionibacterium acnes clearly, minimum bacteriostatic diameter up to 28.5mm,
Facilitation is cooperateed with so as to illustrate that Caulis Akebiae extract has with other components, it is possible to increase suppression of the composition to propionibacterium acnes
Make and use.
The normal individual trial of experimental example 4 is tested
1st, experimental subjects and packet
Choose the facial acne vulgaris volunteer totally 90 of light, moderate, man, female half and half；It is age 18-30 Sui, average 24 years old.
Smear before cosmetics 2 weeks, glucocorticosteroid hormone, tretinoin and antibiotics, no high fat of blood and hepatic and renal function was not used
It is abnormal, forbid excessive drinking, it is to avoid sunburst or ultraviolet excessive radiation.Volunteer is randomly divided into three groups, every group of 30 people：
First group：Warm water cleaning skin and after drying, the active external application elite that every night is prepared using embodiment 2
Liquid is uniformly applied to face, and a 5ml waits for several minutes quietly and treats that Essence is slowly absorbed by the skin, and without cleaning, the next morning is clean
Face；
Second group：Warm water cleaning skin and after drying, the active external application elite that every night is prepared using comparative example 1
Liquid (Caulis Akebiae extract is free of in prescription) is uniformly applied to face, and a 5ml waits for several minutes quietly and treats that Essence is slowly inhaled by skin
Receive, without cleaning, the next morning face cleaning；
3rd group：Warm water cleaning skin and after drying, the active external application elite that every night is prepared using comparative example 2
Liquid (plant extracts is free of in prescription) is uniformly applied to face, and a 5ml waits for several minutes quietly and treats that Essence is slowly inhaled by skin
Receive, without cleaning, the next morning face cleaning.
Other drugs or cosmetics are disabled during use.Continuous on probation 28 days, and require the 14th day (D14) and the of experiment
(D28) is paid a return visit within 28 days.Evaluation content include the Whiteheads of volunteer or so face, blackhead, papule, tumour tubercle with
And the acne of 5 ranks of warts carries out the mark and number statistical of number, while the skin brightness and acne to volunteer
Healing state is observed.As a result it is as shown in table 4 below：
The statistical result of table 4
The result of table 4 shows that first group and second group and the 3rd group effect has notable difference, illustrates wherein containing wood
The active external application Essence of logical extract has the inhibition of highly significant to acne.Under consumption same case, compared to not
Active external application Essence containing Caulis Akebiae extract can significantly improve the effect for suppressing acne.
The healing state of skin brightness and acne to volunteer is observed, and is found compared to second group and the 3rd
Group, the colour of skin of first group of volunteer substantially bleaches, and becomes more flexible, and the skin surface flatness of volunteer has substantially changed
It is kind, have rosy cheeks and glossy, greatly reduce scar and pigmentation, skin is recovered normal fine and smooth soft and smooth.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
Many other changes and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (8)
1. a kind of active external application Essence with anti-inflammatory, promotion skin reparative regeneration and white-skinned face function, it is characterised in that by
A phase, B phase, C phase, D phases and E phase compositions；
Wherein, the A phases by stearine, dimethyl silicone polymer, isononyl isononanoate, jojoba oil, Morocco Ah
Glycerine, fine jade precipice Malus spectabilis oil, isopropyl myristate, octyl stearate, linoleic acid and caprylic/capric triglyceride composition；
The B phases are made up of xanthans, propane diols, butanediol, trehalose, L- pyrrolidones carboxylic sodium and water；
The C phases are rilanit special, Va palmitates, Ve acetates and hyaluronic acid composition；
The D phases are made up of plant extracts, water, niacinamide and preservative：Described plant extracts is by following parts by weight
Each raw material composition：Caulis Akebiae extract 20-40 parts by weight, Angelica Dahurica extract 15-25 parts by weight, Flos Sophorae extract 10-20 weight
Part, Radix Trichosanthis extract 10-20 parts by weight, Polygonum multiflower knotweed extract 10-20 parts by weight, Gentrin Knotweed P.E 15-25 parts by weight, the south of the River
Spikemoss extract 15-25 parts by weight, aloe extract 10-20 parts by weight and mint extract 5-10 parts by weight composition；
The E phases are made up of pH adjusting agent, regulation preparation pH=6.0.
2. activity external application Essence as claimed in claim 1, it is characterised in that described plant extracts is by following parts by weight
Each raw material composition：The parts by weight of Caulis Akebiae extract 30, the parts by weight of Angelica Dahurica extract 20, the parts by weight of Flos Sophorae extract 15, root of Chinese trichosanthes
The parts by weight of extract 15, the parts by weight of Polygonum multiflower knotweed extract 15, the parts by weight of Gentrin Knotweed P.E 20, the weight of Herba Selaginellae Involventis extract 20
Part, the parts by weight of aloe extract 15 and the parts by weight of mint extract 8 composition.
3. activity external application Essence as claimed in claim 1, it is characterised in that described hyaluronic acid is by molecular weight
1800000~2200000Da macromolecule hyaluronic acid, molecular weight is transparent for 1000000~1800000Da middle-molecular-weihydroxyethyl
The macromolecule hyaluronic acid that matter acid and molecular weight are 400000~1000000Da is 1 according to weight ratio:1:1 mixes.
4. activity external application Essence as claimed in claim 1, it is characterised in that in addition to E phases, each raw material is in the active external application
Shared percentage by weight is respectively in Essence：Stearine 1.5~6.0%, dimethyl silicone polymer 0.1~
4.0%th, isononyl isononanoate 0.1~3.0%, jojoba oil 0.5~3.0%, Morocco's Ah's glycerine 0.5~3.0%, Qiong Yahai
Chinese bush cherry oil 3~5.0%, isopropyl myristate 0.5~3.0%, octyl stearate 0.5~5.0%, linoleic acid 0.1~3.0%,
Caprylic/capric triglyceride 1.0~5.0%, xanthans 0.05~0.2%, propane diols 1~3.0%, butanediol 0.1~
3.0%th, trehalose 0.05-1.0%, L- pyrrolidones carboxylic sodium 0.5~2.0%, rilanit special 0.5-3.0%, Va palmitic acid
Ester 0.05~1%, Ve acetates 0.05~0.5%, hyaluronic acid 0.05~0.5%, plant extracts 0.5-5.0%, nicotinoyl
Amine 0.1~2%, preservative 0.05~0.2%, surplus is water.
5. activity external application Essence as claimed in claim 1, it is characterised in that in addition to E phases, each raw material is in the active external application
Shared percentage by weight is respectively in Essence：Stearine 3.5%, dimethyl silicone polymer 2.0%, different n-nonanoic acid are different
Nonyl ester 1.5%, jojoba oil 1.5%, Morocco's Ah's glycerine 1.5%, fine jade precipice Malus spectabilis oil 4.0%, isopropyl myristate
1.5%th, octyl stearate 2.5%, linoleic acid 1.5%, caprylic/capric triglyceride 2.0%, xanthans 0.1%, propane diols
2.0%th, butanediol 1.5%, trehalose 0.5%, L- pyrrolidones carboxylics sodium 1.0%, rilanit special 1.5%, Va palmitates
0.5%th, Ve acetates 0.1%, hyaluronic acid 0.3%, plant extracts 5.0%, niacinamide 2.0%, preservative 0.1%, remaining
Measure as water.
6. activity external application Essence as claimed in claim 1, it is characterised in that the preservative is selected from Phenoxyethanol, Xin Gan
One or more in alcohol, quaternary ammonium salt -15 and dehydroacetic acid.
7. the active external application Essence as described in claim any one of 1-6, it is characterised in that described Caulis Akebiae extract, white
Root of Dahurian angelica extract, Flos Sophorae extract, Radix Trichosanthis extract, Polygonum multiflower knotweed extract, Gentrin Knotweed P.E, Herba Selaginellae Involventis extract, aloe
Extract and mint extract are prepared in accordance with the following methods respectively：
(1) by plant material clean, dry, crush after, and cross 20 mesh sieves；
(2) powder after sieving is subjected to refluxing extraction for 60%~95% ethanol with percent by volume at 75~85 DEG C,
Bulk drug is 1~3 with ethanol mass volume ratio g/mL:10~50, refluxing extraction 3-5h, are carried out 3-4 times, then by extract solution altogether
Merge；Residual residue carries out extraction 2-3 times using hot water, and each 3-5h is cold after extract solution is merged with the extract solution of step (2)
But to 20 DEG C~30 DEG C, 50~100 mesh filter-cloth filterings obtain filtrate；
(4) added in the filtrate obtained to step (3) and the 1,3-BDO of ethanol same volume accumulated amount is miscible uniform, be concentrated under reduced pressure
The ethanol gone out in solution, then vacuum decompression suction filtration, filtrate produces through activated carbon decolorizing, freeze-drying；
(5) Caulis Akebiae extract that will be obtained according to step (1)-(4), Angelica Dahurica extract, Flos Sophorae extract, Radix Trichosanthis extract,
Polygonum multiflower knotweed extract, Gentrin Knotweed P.E, Herba Selaginellae Involventis extract, aloe extract and mint extract are according to claim 1
Well mixed described parts by weight are described plant extracts.
8. a kind of method of the active external application Essence prepared described in claim any one of 1-7, it is characterised in that including as follows
Step：
(1) following raw material is weighed according to the percentage by weight described in claim 4：Stearine, polydimethylsiloxanes
Alkane, isononyl isononanoate, jojoba oil, Morocco's Ah's glycerine, fine jade precipice Malus spectabilis oil, isopropyl myristate, octyl stearate, Asia
Oleic acid, caprylic/capric triglyceride, xanthans, propane diols, butanediol, trehalose, L- pyrrolidones carboxylics sodium, rilanit special,
Va palmitates, Ve acetates, hyaluronic acid and plant extracts；
(2) by stearine, dimethyl silicone polymer, isononyl isononanoate, jojoba oil, Morocco's Ah's glycerine, Qiong Ya
After Malus spectabilis oil, isopropyl myristate, octyl stearate, linoleic acid and caprylic/capric triglyceride mixing, 80 are heated to~
85 DEG C, mix, obtain A phases；
(3) after the water of xanthans, propane diols, butanediol, trehalose, L- pyrrolidones carboxylic sodium and 2/3 volume is mixed, heating
To 80~85 DEG C, mix, obtain B phases；
(4) A phases are all added in B phases, 2000~3000r/min, homogeneous 5min~10min；Sequentially add hydrogenated castor
Oil, Va palmitates, Ve acetates and hyaluronic acid, 2000~3000r/min, 1~3min of homogeneous；30~50r/min, is stirred
Mix after 5~10min, start stirring cooling, stir speed (S.S.) is 30~50r/min, and rate of temperature fall is 1~2 DEG C/min；
(5) water of remaining 1/3 volume is added into plant extracts, after dissolving completely, temperature is added and drops to 45~50 DEG C
In the mixture that step (4) is obtained, niacinamide and preservative are added, is stirred, continue to be cooled to less than 40 DEG C；
(6) preparation pH=6.0 is adjusted using pH adjusting agent, produced.
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| CN201710346315.5A CN107184511A (en) | 2017-05-17 | 2017-05-17 | A kind of active external application Essence with anti-inflammatory, promotion skin reparative regeneration and white-skinned face function and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478455A (en) * | 2018-04-26 | 2018-09-04 | 王玉玉 | A kind of Essence and its application method |
| CN111388384A (en) * | 2020-03-25 | 2020-07-10 | 广州瑶芳皮肤健康管理有限公司 | Acne-removing essence containing Chinese herbal medicine composition and preparation method thereof |
| CN112190509A (en) * | 2020-09-11 | 2021-01-08 | 广州优理氏生物科技有限公司 | Composite plant extract and preparation method and application thereof |
| CN115414297A (en) * | 2022-09-19 | 2022-12-02 | 上海若梵生物科技有限公司 | Whitening essence and preparation method thereof |
-
2017
- 2017-05-17 CN CN201710346315.5A patent/CN107184511A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478455A (en) * | 2018-04-26 | 2018-09-04 | 王玉玉 | A kind of Essence and its application method |
| CN111388384A (en) * | 2020-03-25 | 2020-07-10 | 广州瑶芳皮肤健康管理有限公司 | Acne-removing essence containing Chinese herbal medicine composition and preparation method thereof |
| CN112190509A (en) * | 2020-09-11 | 2021-01-08 | 广州优理氏生物科技有限公司 | Composite plant extract and preparation method and application thereof |
| CN115414297A (en) * | 2022-09-19 | 2022-12-02 | 上海若梵生物科技有限公司 | Whitening essence and preparation method thereof |
| CN115414297B (en) * | 2022-09-19 | 2023-08-15 | 上海若梵生物科技有限公司 | Whitening essence and preparation method thereof |
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Application publication date: 20170922 |