CN108542805A - Anti-acne compound essential oil preparation and its preparation method and application - Google Patents
Anti-acne compound essential oil preparation and its preparation method and application Download PDFInfo
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Abstract
The present invention provides a kind of anti-acne compound essential oil preparations and its preparation method and application,It is related to medical cosmetic technical field,The anti-acne compound essential oil preparation includes 15 parts of Forsythia suspense essential oil,0.1 1 parts of schizonepeta essential oil,0.1 1 parts of frutus cnidii essential oil,0.1 1 parts of grass-leaved sweetflag essential oil,0.05 0.5 parts of Peppermint essential oil,0.1 1 parts of Lavender,12 parts of dandelion essential oil,5 10 parts of snake oil,20 30 parts of grape seed oil,20 30 parts of maize germ oil,10 25 parts of 10 20 parts of tea oil and SIMMONDSIA CHINENSIS SEED OIL,It is big and of high cost to improve existing Western medicine anti-acne poisonous side effect of medicine,The effect of folk prescription essential oil is single,The inapparent technical problem of curative effect,The anti-acne compound essential oil can not only adjust sebum secretion balance,Anti-inflammatory sterilization,Self maintenance of active cell,And acne print can be desalinated,It releives skin,It is safe and efficient simultaneously,It has no toxic side effect,Patient suffering can be effectively relieved.
Description
Technical field
The present invention relates to medical cosmetic technical fields, more particularly, to a kind of anti-acne compound essential oil preparation and its preparation side
Method and application.
Background technology
Whelk is also referred to as acne, is the chronic inflammatory conditions that related hair follicle, sebaceous glands are metabolized with sebum, because teenager exists
Adolescence metabolism is more vigorous, therefore is mainly in puberty.According to statistics, there is 95% Adolescent male and 85%
Women suffered from different degrees of whelk.In addition, since sebum metabolism betided in the entire all one's life of people, whelk
It is very easy to recurrence, not only in young man or even part a middle-aged person is also frequently subjected to the puzzlement of whelk.
Currently, having tretinoin, benzoyl peroxide, antibiotics, azelaic acid, sulphur for anti-acne local topical drug
The toxic side effect of the Western medicine such as lotion, Western medicine is big and of high cost；Most of acne removal essential oil on the market is that folk prescription essential oil adds base oil
Allotment is made, and effect is single, and curative effect is not notable.
In view of this, special propose the present invention.
Invention content
One of the objects of the present invention is to provide a kind of anti-acne compound essential oil preparations, are west to improve existing anti-acne drug
Medicine or folk prescription essential oil, Western medicine toxic side effect is big and of high cost, and folk prescription essential oil acts on single, the inapparent technical problem of curative effect.
Anti-acne compound essential oil preparation provided by the invention, including following component according to the mass fraction：Forsythia suspense essential oil 1-5
Part, 0.1-1 parts of schizonepeta essential oil, 0.1-1 parts of frutus cnidii essential oil, 0.1-1 parts of grass-leaved sweetflag essential oil, 0.05-0.5 parts of Peppermint essential oil smoke
0.1-1 parts of clothing grass essential oil, 1-2 parts of dandelion essential oil, 5-10 parts of snake oil, 20-30 parts of grape seed oil, 20-30 parts of maize germ oil,
10-25 parts of 10-20 parts of tea oil and SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Further, the anti-acne compound essential oil preparation includes following component according to the mass fraction：Forsythia suspense essential oil 2-4
Part, 0.4-1 parts of schizonepeta essential oil, 0.2-0.7 parts of frutus cnidii essential oil, 0.2-0.8 parts of grass-leaved sweetflag essential oil, Peppermint essential oil 0.05-0.45
Part, 0.15-0.8 parts of Lavender, 1.5-2 parts of dandelion essential oil, 6-9 parts of snake oil, 20-30 parts of grape seed oil, maize germ
20-30 parts oily, 10-25 parts of 10-20 parts of tea oil and SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Further, the anti-acne compound essential oil preparation includes following component according to the mass fraction：Forsythia suspense essential oil 3-4
Part, 0.5-0.8 parts of schizonepeta essential oil, 0.4-0.6 parts of frutus cnidii essential oil, 0.3-0.7 parts of grass-leaved sweetflag essential oil, Peppermint essential oil 0.2-0.4
Part, 0.3-0.7 parts of Lavender, 1.5-2 parts of dandelion essential oil, 7-8 parts of snake oil, 20-30 parts of grape seed oil, maize germ oil
20-30 parts, 10-20 parts of tea oil and 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
Further, the anti-acne compound essential oil preparation further includes 0.2-1 parts of auxiliary agent according to the mass fraction；
Preferably, the auxiliary agent includes gelling agent, moisturizer or at least one of the preservatives.
Further, the gelling agent is selected from methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, poly- second
At least one of glycol or polyvinyl alcohol.
Further, the moisturizer is selected from diethylene glycol, dipropylene glycol, ethylene glycol, hexylene glycol, isoprene, fourth two
At least one of alcohol or pentanediol.
Further, the preservative is Phenoxyethanol and/or Sensiva SC50.
The second object of the present invention is to provide the preparation method of above-mentioned anti-acne compound essential oil preparation, include the following steps：
By Forsythia suspense essential oil, schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion
Essential oil, snake oil, grape seed oil, maize germ oil, tea oil, SIMMONDSIA CHINENSIS SEED OIL and optional auxiliary agent are uniformly mixed, and obtain anti-acne
Compound essential oil preparation.
Further, first grape seed oil, maize germ oil, tea oil and SIMMONDSIA CHINENSIS SEED OIL are uniformly mixed, are sequentially added
Snake oil, Forsythia suspense essential oil, dandelion essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Lavender, frutus cnidii essential oil, Peppermint essential oil and
Optional auxiliary agent is uniformly mixed.
The third object of the present invention is to provide application of the above-mentioned anti-acne compound essential oil preparation in skin care item.
The base that anti-acne compound essential oil preparation provided by the invention is combined in traditional Chinese medicine compatibility theory and essential oil blending technology
Under plinth, pass through Forsythia suspense essential oil, Jing Jie essential oils, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion essence
Oil, snake oil, grape seed oil, maize germ oil and the mutual coordinated of SIMMONDSIA CHINENSIS SEED OIL can not only adjust sebum secretion balance, resist
Inflammation sterilization, active cell self maintenance, and acne print can be desalinated, skin of releiving, at the same it is safe and efficient, it has no toxic side effect, energy
Enough rapid recovery patient sufferings.
The preparation method of anti-acne compound essential oil preparation provided by the invention is simple for process, easy to operate, is suitable for industrialization
Big production, can effectively improve production efficiency.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to the first aspect of the invention, the present invention provides a kind of anti-acne compound essential oil preparations, including press mass parts
The following component of number meter：1-5 parts of Forsythia suspense essential oil, 0.1-1 parts of schizonepeta essential oil, 0.1-1 parts of frutus cnidii essential oil, grass-leaved sweetflag essential oil 0.1-
1 part, 0.05-0.5 parts of Peppermint essential oil, 0.1-1 parts of Lavender, 1-2 parts of dandelion essential oil, 5-10 parts of snake oil, grape seed oil
20-30 parts, 20-30 parts of maize germ oil, 10-20 parts of tea oil and 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100
Part.
In the present invention, the typical but non-limiting mass fraction of Forsythia suspense essential oil as 1,1.2,1.5,1.8,2,2.2,
2.5,2.8,3,3.2,3.5,3.8,4,4.2,4.5,4.8 or 5 parts.Forsythia suspense essential oil has clearing heat and detoxicating, blood cooling and ecchymoses removing and antioxygen
The effect of change.
The typical but non-limiting mass fraction of schizonepeta essential oil as 0.1,0.15,0.2,0.25,0.3,0.35,0.4,
0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Schizonepeta essential oil have antipyretic-antalgic and
The effect of anti-inflammatory.
The typical but non-limiting mass fraction of frutus cnidii essential oil as 0.1,0.15,0.2,0.25,0.3,0.35,
0.4,0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Frutus cnidii essential oil has eliminating dampness
With antipruritic effectiveness.
The typical but non-limiting mass fraction of grass-leaved sweetflag essential oil as 0.1,0.15,0.2,0.25,0.3,0.35,
0.4,0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Grass-leaved sweetflag essential oil has dampness elimination
The effect of calmness, swelling and pain relieving.
The typical but non-limiting mass fraction of Peppermint essential oil as 0.05,0.08,0.1,0.12,0.15,0.18,
0.2,0.22,0.25,0.28,0.3,0.32,0.35,0.38,0.4,0.42,0.45,0.48 or 0.5 part.Peppermint essential oil has
The effect of antiallergic, promoting eruption, sterilization and analgesia.
The typical but non-limiting mass fraction of Lavender as 0.1,0.15,0.2,0.25,0.3,0.35,
0.4,0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Lavender, which has, to kill
The effect of bacterium, disinfection, calmness and removing toxic substances, the effect of while cytothesis can also being accelerated, promote rehabilitation, prevent scar.
The typical but non-limiting mass fraction of dandelion essential oil as 1,1.1,1.15,1.2,1.25,1.3,1.35,
1.4,1.45,1.5,1.55,1.6,1.65,1.7,1.75,1.8,1.85,1.9,1.95 or 2 parts.Dandelion essential oil has heat-clearing
Swollen effect is gone in removing toxic substances, anti-inflammatory.
The typical but non-limiting mass fraction of snake oil as 5,5.2,5.5,5.8,6,6.2,6.5,6.8,7,7.2,
7.5,7.8,8,8.2,8.5,8.8,9,9.2,9.5,9.8 or 10 parts.
Snake oil, the i.e. fat of snake have good permeability containing unsaturated fatty acid, leukotrienes, linoleic acid.With tune
Endocrine disorder is saved, is relaxed bowel, skin maintenance prevents skin aging, prevents vascular sclerosis, detumescence, inhibits bacterial growth, promotees
Into the effect of blood circulation.
The typical but non-limiting mass fraction of grape seed oil as 20,20.5,21,21.5,22,22.5,23,
23.5,24,24.5,25,25.5,26,26.5,27,27.5,28,28.5,29,29.5 or 30 parts.Grape seed oil has strong infiltration
Property, can moisten soft skin, have effects that anti-oxidant and convergence.
The typical but non-limiting mass fraction of maize germ oil as 20,20.5,21,21.5,22,22.5,23,
23.5,24,24.5,25,25.5,26,26.5,27,27.5,28,28.5,29,29.5 or 30 parts.Maize germ oil has skin softening
The effect of beauty and anti-aging, regeneration and the vigor of human body cell can be promoted, postpone the aging of cell.
The typical but non-limiting mass fraction of tea oil as 10,10.5,11,11.5,12,12.5,13,13.5,
14,14.5,15,15.5,16,16.5,17,17.5,18,18.5,19,19.5 or 20 parts.Tea oil has strong permeability, has
Antibacterial and anti-inflammatory effect.
The typical but non-limiting mass fraction of SIMMONDSIA CHINENSIS SEED OIL as 10,10.5,11,11.5,12,12.5,13,
13.5、14、14.5、15、15.5、16、16.5、17、17.5、18、18.5、19、19.5、20、20.5、21、21.5、22、22.5、
23,23.5,24,24.5 or 25 parts.SIMMONDSIA CHINENSIS SEED OIL has strong permeability, can moisten moisturizing, maintaining skin.
In the present invention, essential oil is 99.9% original effect that ensure that plant where the essence of vegetation.The present invention carries
The anti-acne compound essential oil preparation of confession is prepared by a variety of essential oils compounding, and plants essential oil has following advantage：
(1) small molecule, high osmosis, oleophylic water resistant Transdermal absorption：The pore dia of human epidermal is 60-80um
(1000 microns=1 millimeter), and it is 1/5000000 that essential oil molecule is only its 1/1000 to be compared with human body cell, therefore essential oil
Can very rapidly penetrate to the skin and blood in.Essential oil is eager to excel 70 times than the miserable permeability of Chinese herbal medicine (forms such as extracting solution, powder),
Therefore essential oil can very rapidly penetrate to the skin in deep layer and blood, 3 seconds reachable epidermis, 6 seconds reachable skin coriums,
Into subcutaneous tissue, arrival blood carries out the blood circulation of whole body within 6 minutes within 3 minutes, plays purification tissue, confrontation inherence carefully
The effect of bacterium.Avoid oral drugs to lesions of liver and kidney, using Transdermal absorption, the efficacy of a drug directly permeates lesion, quickly relieves symptoms.
(2) effect is powerful：Essential oil is 99.9% original effect that ensure that plant, due to oozing where the essence of draft
Thoroughly especially fast, pharmacological property is high, therefore on a small quantity can perform to drug effect ultimate attainment, can accomplish fast onset.The efficacy of a drug is gone directly lesion,
It is rapid to alleviate illness.
(3) it has no toxic side effect：Essential oil is made from natural plant extraction, pure health, and raw material is only retained in extraction process
In most effective ingredient, refuse any addition and chemical composition, allow skin enjoy no pollution.
(4) health is non-stimulated：Currently, that there are toxic side effects is strong, is also easy to produce drug resistance and medicine for the Western medicine class such as antibiotic drug
The problems such as object remains, clinical application is very limited.And plants essential oil it is green, natural, safe efficient with it the features such as become
The excellent substitute of antibiotic.
The base that anti-acne compound essential oil preparation provided by the invention is combined in traditional Chinese medicine compatibility theory and essential oil blending technology
Under plinth, pass through Forsythia suspense essential oil, Jing Jie essential oils, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion essence
Oil, snake oil, grape seed oil, maize germ oil and the mutual coordinated of SIMMONDSIA CHINENSIS SEED OIL can not only adjust sebum secretion balance, resist
Inflammation sterilization, active cell self maintenance, and acne print can be desalinated, skin of releiving, at the same it is safe and efficient, it has no toxic side effect, energy
Enough rapid recovery patient sufferings.
Anti-acne compound essential oil preparation provided by the invention further includes a variety of non-essential components, they aesthetically more hold
It is easily accepted, or the composition is made to use benefit with additional.This variety of constituents are known in professionals in the field
's.They include but not limited to fatty alcohol, sodium chloride, ethyl alcohol, pH adjusting agent, colorant, suspending agent, sun-screening agent, thickener and
Viscosity modifier etc..
In the preferred embodiment of the present invention, anti-acne compound essential oil preparation further includes 0.2-1 parts of auxiliary agent.
In the present invention, the typical but non-limiting mass fraction of auxiliary agent as 0.2,0.25,0.3,0.35,0.4,
0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.
In present invention further optimization embodiment, auxiliary agent include in gelling agent, moisturizer or preservative at least
It is a kind of.
[gelling agent]
In a kind of preferred embodiment of the present invention, gelling agent is water-soluble high-molecular substance, including but not limited to naturally
Polymer substance, modified natural polymer substance and synthetic high polymer matter.
Water-soluble high-molecular substance is preferably cellulose family and its derivative, such as methylcellulose, hydroxypropyl methyl fiber
Element, hydroxypropyl methylcellulose phthalate, hydroxypropyl methyl cellulose succinate, hydroxymethyl ethylcellulose, carboxylic
Methylethylcellulose, sodium carboxymethylcellulose, hydroxyethyl cellulose, cellulose acetate phthalate.
It includes but not limited to polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene acetal two to synthesize macromolecule
Ethylamino mistake acid esters, Eudragit E100-E, Eudragit E100-RS, methyl
Acrylic copolymer-L, methacrylic acid copolymer-LD, methacrylic acid copolymer-S and carboxyl vinyl polymer etc..
Natural polymer and carbohydrate include but not limited to Arabic gum, mosanom, propylene glycol alginate, agar, gelatin and
Xanthans etc..
In present invention further optimization embodiment, gelling agent be selected from methylcellulose, hydroxypropyl methyl cellulose,
The composition of one or more of hydroxypropyl cellulose, polyethylene glycol or polyvinyl alcohol.
[moisturizer]
In a preferred embodiment of the invention, moisturizing and be selected from polyol agent.
Polyalcohol includes but not limited to glycol and Aethoxy Sklerol.
Glycol is selected from diethylene glycol, dipropylene glycol, ethylene glycol, propylene glycol, hexylene glycol, isoprene, butanediol, penta 2
The composition of one or more of alcohol, butanediol, 1,2- propane diols, pentane diol, decanediol and dodecanediol.
In the preferred embodiment of the present invention, the number-average molecular weight of Aethoxy Sklerol is 150-600, such as polyethylene glycol
300 and polyglycereol 500 etc..
[preservative]
In the preferred embodiment of the present invention, preservative includes but not limited to Phenoxyethanol and/or ethylhexyl
Glycerine.
According to the second aspect of the invention, the present invention provides the preparation method of above-mentioned anti-acne compound essential oil preparation, packets
Include following steps：
By Forsythia suspense essential oil, schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion
Essential oil, snake oil, grape seed oil, maize germ oil, tea oil, SIMMONDSIA CHINENSIS SEED OIL and optional auxiliary agent are uniformly mixed, and obtain anti-acne
Compound essential oil preparation.
The preparation method of anti-acne compound essential oil preparation provided by the invention is simple for process, easy to operate, is suitable for industrialization
Big production, can effectively improve production efficiency.
In the preferred embodiment of the present invention, in the preparation process for carrying out anti-acne compound essential oil preparation, first will
Grape seed oil, maize germ oil, tea oil and SIMMONDSIA CHINENSIS SEED OIL are uniformly mixed, and sequentially add snake oil, Forsythia suspense essential oil, dandelion essence
Oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Lavender, frutus cnidii essential oil, Peppermint essential oil and optional auxiliary agent are uniformly mixed.
It is sequentially added container by anti-acne compound essential oil preparation provided by the invention from big to small according to each component ratio
In, it after sealing, firmly rolls, so that all components is uniformly mixed, obtain anti-acne compound essential oil preparation.
The application method of anti-acne compound essential oil preparation provided by the invention is simple, and medication is convenient, before having wide application
Scape.
The third object of the present invention is to provide application of the above-mentioned anti-acne compound essential oil preparation in skin care item.
In the present invention, skin care item include but not limited to face cream, facial mask and shin moisturizer etc..
Technical solution provided by the invention is further described with reference to embodiment and comparative example.
Embodiment 1
Present embodiments provide a kind of anti-acne compound essential oil preparation, including following component according to the mass fraction：Fructus Forsythiae essence
1 part of oil, 1 part of schizonepeta essential oil, 0.1 part of frutus cnidii essential oil, 1 part of grass-leaved sweetflag essential oil, 0.05 part of Peppermint essential oil, 1 part of Lavender,
1 part of dandelion essential oil, 10 parts of snake oil, 20 parts of grape seed oil, 30 parts of maize germ oil, 10 parts of tea oil and SIMMONDSIA CHINENSIS SEED OIL 24.85
Part.
Embodiment 2
Present embodiments provide a kind of anti-acne compound essential oil preparation, including following component according to the mass fraction：Fructus Forsythiae essence
5 parts of oil, 0.1 part of schizonepeta essential oil, 1 part of frutus cnidii essential oil, 0.1 part of grass-leaved sweetflag essential oil, 0.5 part of Peppermint essential oil, Lavender 0.1
Part, 2 parts of dandelion essential oil, 5 parts of snake oil, 30 parts of grape seed oil, 20 parts of maize germ oil, 20 parts of tea oil and SIMMONDSIA CHINENSIS SEED OIL 16.2
Part.
Embodiment 3
Present embodiments provide a kind of anti-acne compound essential oil preparation, including following component according to the mass fraction：Fructus Forsythiae essence
2 parts of oil, 1 part of schizonepeta essential oil, 0.2 part of frutus cnidii essential oil, 0.8 part of grass-leaved sweetflag essential oil, 0.05 part of Peppermint essential oil, Lavender
0.8 part, 1.5 parts of dandelion essential oil, 9 parts of snake oil, 24 parts of grape seed oil, 25.65 parts of corn wheat germ oil, 15 parts of tea oil and lotus
20 parts of lotus bar oil.
Embodiment 4
Present embodiments provide a kind of anti-acne compound essential oil preparation, including following component according to the mass fraction：Fructus Forsythiae essence
4 parts of oil, 0.4 part of schizonepeta essential oil, 0.7 part of frutus cnidii essential oil, 0.2 part of grass-leaved sweetflag essential oil, 0.45 part of Peppermint essential oil, Lavender
0.15 part, 2 parts of dandelion essential oil, 6 parts of snake oil, 25.1 parts of grape seed oil, 25 parts of maize germ oil, 18 parts of tea oil and Jojoba
18 parts of oil.
Embodiment 5
Present embodiments provide a kind of anti-acne compound essential oil preparation, including following component according to the mass fraction：Fructus Forsythiae essence
3 parts of oil, 0.8 part of schizonepeta essential oil, 0.4 part of frutus cnidii essential oil, 0.7 part of grass-leaved sweetflag essential oil, 0.2 part of Peppermint essential oil, Lavender
0.7 part, 1.8 parts of dandelion essential oil, 7 parts of snake oil, 25 parts of grape seed oil, 16.4 parts of maize germ oil, 12 parts of tea oil and lotus lotus
Bar 22 parts of oil.
Embodiment 6
Present embodiments provide a kind of anti-acne compound essential oil preparation, including following component according to the mass fraction：Fructus Forsythiae essence
4 parts of oil, 0.5 part of schizonepeta essential oil, 0.6 part of frutus cnidii essential oil, 0.3 part of grass-leaved sweetflag essential oil, 0.4 part of Peppermint essential oil, Lavender
0.3 part, 1.7 parts of dandelion essential oil, 8 parts of snake oil, 30 parts of grape seed oil, 20 parts of maize germ oil, 18 parts of tea oil and Jojoba
16.2 parts of oil.
Embodiment 7
Present embodiments provide a kind of anti-acne compound essential oil preparation, including following component according to the mass fraction：Fructus Forsythiae essence
3.5 parts of oil, 0.6 part of schizonepeta essential oil, 0.5 part of frutus cnidii essential oil, 0.5 part of grass-leaved sweetflag essential oil, 0.3 part of Peppermint essential oil, lavender essence
0.5 part of oil, 1.8 parts of dandelion essential oil, 7.5 parts of snake oil, 22.8 parts of grape seed oil, 25 parts of maize germ oil, 15 parts of tea oil and
22 parts of SIMMONDSIA CHINENSIS SEED OIL.
Embodiment 8
Present embodiments provide a kind of preparation method of anti-acne compound essential oil preparation, the anti-acne compound that embodiment 1-7 is provided
Essential oil formulation is prepared in accordance with the following steps：
First grape seed oil, maize germ oil, tea oil and SIMMONDSIA CHINENSIS SEED OIL are uniformly mixed, sequentially add snake oil, Fructus Forsythiae
It essential oil, dandelion essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Lavender, frutus cnidii essential oil, Peppermint essential oil and optional helps
Agent firmly rolls, and so that above-mentioned various ingredients is uniformly mixed, obtains anti-acne compound essential oil preparation.
Comparative example 1
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, even
Stick up 0.1 part of essential oil, 3 parts of schizonepeta essential oil, 2 parts of frutus cnidii essential oil, 3 parts of grass-leaved sweetflag essential oil, 1 part of Peppermint essential oil, Lavender 3
Part, 0.1 part of dandelion essential oil, 40 parts of grape seed oil, 2 parts of snake oil, 35 parts of maize germ oil, 5.8 parts of tea oil and SIMMONDSIA CHINENSIS SEED OIL 5
Part.
Comparative example 2
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, even
Stick up 10 parts of essential oil, 0.05 part of schizonepeta essential oil, 0.05 part of frutus cnidii essential oil, 0.05 part of grass-leaved sweetflag essential oil, 0.01 part of Peppermint essential oil smokes
0.04 part of clothing grass essential oil, 5 parts of dandelion essential oil, 15 parts of grape seed oil, 20 parts of snake oil, 6 parts of maize germ oil, 8.8 parts of tea oil,
35 parts of SIMMONDSIA CHINENSIS SEED OIL.
Comparative example 3
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Forsythia suspense essential oil is added.
Comparative example 4
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Dandelion essential oil is added.
Comparative example 5
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Snake oil is added.
Comparative example 6
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Schizonepeta essential oil is added.
Comparative example 7
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Frutus cnidii essential oil is added.
Comparative example 8
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Grass-leaved sweetflag essential oil is added.
Comparative example 9
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Peppermint essential oil is added.
Comparative example 10
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Lavender is added.
Comparative example 11
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Tea oil is added.
Comparative example 12
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Maize germ oil is added.
Comparative example 13
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, not
Grape seed oil is added.
Comparative example 14
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, even
It is 7.7 parts to stick up essential oil, and it is public that schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender and Pu are not added
English essential oil.
Comparative example 15
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, chaste tree
Mustard essential oil is 7.7 parts, and it is public that Forsythia suspense essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender and Pu are not added
English essential oil.
Comparative example 16
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, snake
Machine tool essential oil is 7.7 parts, and it is public that Forsythia suspense essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender and Pu are not added
English essential oil.
Comparative example 17
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, stone
Calamus essential oil is 7.7 parts, and it is public that Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, Peppermint essential oil, Lavender and Pu are not added
English essential oil.
Comparative example 18
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, it is thin
Lotus essential oil is 7.7 parts, and it is public that Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Lavender and Pu are not added
English essential oil.
Comparative example 19
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, smoke
Clothing grass essential oil is 7.7 parts, and it is public that Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil and Pu are not added
English essential oil.
Comparative example 20
This comparative example provides a kind of anti-acne compound essential oil preparation, this comparative example with embodiment 7 the difference is that, Pu
Public English essential oil is 7.7 parts, and Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil are not added and smokes clothing
Careless essential oil.
Comparative example 21
This comparative example provides a kind of blemish clearing gel, which is commercially available Clindamycin Phosphate Gel.
Comparative example 22
This comparative example provides a kind of PBS solution.
The anti-acne compound that the preparation method for the anti-acne compound essential oil preparation that above-mentioned comparative example 1-20 is provided is provided with embodiment 7
The preparation method of essential oil formulation is identical, and details are not described herein.
Test example 1
In order to verify the fungistatic effect of anti-acne compound essential oil preparation provided by the invention, spy dispels what embodiment 1-7 was provided
Blemish clearing gel that the anti-acne compound essential oil preparation and comparative example 21-22 that acne compound essential oil preparation and comparative example 1-20 are provided provide and
Solution carries out the In Vitro Bacteriostatic test of acne pathogenic bacteria respectively.
1.1 bacterial strain
Propionibacterium acnes reference culture, staphylococcus aureus reference culture and Escherichia coli reference culture.
1.2 test methods one
Three kinds of bacterial strains are first prepared into 10 with 0.03mol/L PBS solutions respectively5The bacteria suspension of cfu/ml is spare, then root
Embodiment 1-7 and comparative example 1-22 the anti-acne substance provided are carried out respectively according to suspension quantitative method as defined in QB/T2738-2012
Acne pathogenic bacteria bacteriostasis rate is evaluated, and the results are shown in Table 1：
1 acne pathogenic bacteria bacteriostasis rate tables of data of table
As it can be seen from table 1 the anti-acne compound essential oil preparation that embodiment 1-7 is provided acts on 10min with corresponding bacteria suspension
When, 82% is higher than to the bacteriostasis rate of staphylococcus aureus, 78% is higher than to the bacteriostasis rate of propionibacterium acnes, to Escherichia coli
Bacteriostasis rate be higher than 98%, this illustrates that anti-acne compound essential oil preparation provided by the invention can significantly inhibit the life of acne pathogenic bacteria
It is long, sebum secretion balance is adjusted, the pain of patient is effectively relieved.
Anti-acne compound essential oil preparation pair provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 22
The inhibiting effect of staphylococcus aureus, propionibacterium acnes and Escherichia coli is notable.
Anti-acne compound essential oil preparation pair provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 21
The a little higher than Clindamycin Phosphate Gel of inhibiting effect of staphylococcus aureus, propionibacterium acnes and Escherichia coli, and its
It is formed using the essential oil and formulation of base oil of natural green, it is without any side effects, it is healthier, it is safer, it is more environmentally friendly.
Anti-acne compound essential oil preparation provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 1-20
Under the basis that traditional Chinese medicine compatibility and essential oil allotment are combined, pass through the Forsythia suspense essential oil of extra fine quality number, Jing Jie essential oils, cnidium monnieri
Sub- essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion essential oil, snake oil, grape seed oil, maize germ oil and lotus
The mutual coordinated of lotus bar oil, anti-microbial property is more preferable, and more can effectively releive skin, promote the recovery from illness of acne.
1.3 test methods two
Three kinds of bacterial strains are prepared into 10 according to 1.2 method5The bacteria suspension of cfu/ml, then according to QB/T2738-2012
Defined antibacterial ring size evaluation method carries out acne pathogenic bacteria suppression to embodiment 1-7 and comparative example 1-22 the anti-acne substance provided respectively
Collarium measuring diameter, the results are shown in Table 2：
2 acne pathogenic bacteria inhibition zone diameter tables of data of table
From table 2 it can be seen that the staphylococcic antibacterial ring size of anti-acne compound essential oil formulation against S that embodiment 1-7 is provided
Diameter is more than 22.5mm, is more than 24.5mm to the inhibition zone diameter of propionibacterium acnes, big to the inhibition zone diameter of Escherichia coli
In 35mm, this illustrates that anti-acne compound essential oil preparation provided by the invention can significantly inhibit the growth of acne pathogenic bacteria, adjusts skin
Fat secretion balance, is effectively relieved the pain of patient.
Anti-acne compound essential oil preparation pair provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 22
Staphylococcus aureus, propionibacterium acnes and Escherichia coli inhibiting effect are notable.
Anti-acne compound essential oil preparation pair provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 21
The inhibition zone diameter of staphylococcus aureus, propionibacterium acnes and Escherichia coli is slightly larger than the suppression of Clindamycin Phosphate Gel
Collarium diameter, and it uses the essential oil of natural green and formulation of base oil to form, it is without any side effects, it is healthier, it is safer,
It is more environmentally friendly, it is more preferable to the inhibiting effect of acne pathogenic bacteria.
Anti-acne compound essential oil preparation provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 1-20
Under the basis that traditional Chinese medicine compatibility and essential oil allotment are combined, pass through the Forsythia suspense essential oil of extra fine quality number, Jing Jie essential oils, cnidium monnieri
Sub- essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion essential oil, snake oil, grape seed oil, maize germ oil and lotus
The mutual coordinated of lotus bar oil, anti-microbial property is more preferable, and more can effectively releive skin, promote the recovery from illness of acne.
Test example 2
For the practical effect of testing example 1-7 and comparative example 1-22 the anti-acne substance provided, according to《Cosmetics connect
Touch property dermatitis diagnostic criteria and treatment principle》Routinely patients with acne 2900 carries out crowd's investigation on probation to screening face, will
2900 target users are divided into 29 groups, and every group of 100 people, 1-7 groups use the anti-acne compound essential oil system that embodiment 1-7 is provided respectively
Agent, the anti-acne substance that 8-29 groups are provided using comparative example 1-22 groups respectively, application method are：Being used after the daily face cleaning of patients with acne will
Anti-acne substance treats acne coated on site of disease, and each smearing is primary sooner or later, tries out surrounding, while filling in investigation volume, finally counts
As a result.The anti-acne effect of anti-acne compound essential oil preparation is examined, the results are shown in Table 3：
3 patients with acne using effect evaluation table of table
Note：Effective standard is that acne largely disappears, and occurs without new acne；Effective standard is acne part hour
And remission, occasionally there is new acne to occur；Invalid standard is acne phenomenon without significant change.
It can be seen that anti-acne compound essential oil preparation provided by the invention from table 3 with 29 groups of comparison and can quickly ooze for 1 group
Transdermal inhibits the growth of acne pathogenic bacteria, adjusts sebum secretion balance, and the effective percentage after four weeks reaches 100%.
By 1-7 groups and 28 groups of comparison as can be seen that anti-acne compound essential oil preparation provided by the invention shows acne
The a little higher than Clindamycin Phosphate Gel of speed is imitated, therapeutic effect is also slightly better than Clindamycin Phosphate Gel.
Anti-acne compound essential oil preparation provided by the invention is can be seen that in traditional Chinese medicine by the comparison of 1-7 groups and 8-27 groups
Under compatibility and the basis that is combined of essential oil allotment, by the Forsythia suspense essential oil of extra fine quality number, Jing Jie essential oils, frutus cnidii essential oil,
Grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion essential oil, snake oil, grape seed oil, maize germ oil and SIMMONDSIA CHINENSIS SEED OIL
Mutual coordinated, to acne it is effective faster, therapeutic effect is more preferably.
In addition, this time investigation also investigates facial excitement, investigation result shows that 1-27 group crowds are non-stimulated
Sense record, and 28 groups of crowds have 8 people to think there is obvious stimulation sense, 32 people think slightly excitement, this explanation is provided by the invention
Anti-acne compound essential oil preparation natural green, it is safe and efficient, it has no toxic side effect, will not affect human health.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of anti-acne compound essential oil preparation, which is characterized in that including following component according to the mass fraction：Forsythia suspense essential oil 1-5
Part, 0.1-1 parts of schizonepeta essential oil, 0.1-1 parts of frutus cnidii essential oil, 0.1-1 parts of grass-leaved sweetflag essential oil, 0.05-0.5 parts of Peppermint essential oil smoke
0.1-1 parts of clothing grass essential oil, 1-2 parts of dandelion essential oil, 5-10 parts of snake oil, 20-30 parts of grape seed oil, 20-30 parts of maize germ oil,
10-25 parts of 10-20 parts of tea oil and SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
2. anti-acne compound essential oil preparation according to claim 1, which is characterized in that including according to the mass fraction such as the following group
Point：2-4 parts of Forsythia suspense essential oil, 0.4-1 parts of schizonepeta essential oil, 0.2-0.7 parts of frutus cnidii essential oil, 0.2-0.8 parts of grass-leaved sweetflag essential oil, peppermint
0.05-0.45 parts of essential oil, 0.15-0.8 parts of Lavender, 1.5-2 parts of dandelion essential oil, 6-9 parts of snake oil, grape seed oil 20-
30 parts, 20-30 parts of maize germ oil, 10-20 parts of tea oil and 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
3. anti-acne compound essential oil preparation according to claim 1, which is characterized in that including according to the mass fraction such as the following group
Point：3-4 parts of Forsythia suspense essential oil, 0.5-0.8 parts of schizonepeta essential oil, 0.4-0.6 parts of frutus cnidii essential oil, 0.3-0.7 parts of grass-leaved sweetflag essential oil are thin
0.2-0.4 parts of lotus essential oil, 0.3-0.7 parts of Lavender, 1.5-2 parts of dandelion essential oil, 7-8 parts of snake oil, grape seed oil 20-30
Part, 20-30 parts of maize germ oil, 10-20 parts of tea oil and 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
4. according to claim 1-3 any one of them anti-acne compound essential oil preparations, which is characterized in that further include by mass fraction
0.2-1 parts of the auxiliary agent of meter；
Preferably, the auxiliary agent includes gelling agent, moisturizer or at least one of the preservatives.
5. anti-acne compound essential oil preparation according to claim 4, which is characterized in that the gelling agent is selected from Methyl cellulose
At least one of element, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, polyethylene glycol or polyvinyl alcohol.
6. anti-acne compound essential oil preparation according to claim 4, which is characterized in that the moisturizer be selected from diethylene glycol,
At least one of dipropylene glycol, ethylene glycol, hexylene glycol, isoprene, butanediol or pentanediol.
7. anti-acne compound essential oil preparation according to claim 4, which is characterized in that the preservative be Phenoxyethanol and/
Or Sensiva SC50.
8. according to the preparation method of claim 1-7 any one of them anti-acne compound essential oil preparations, which is characterized in that including such as
Lower step：
By Forsythia suspense essential oil, schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, dandelion essential oil,
Snake oil, grape seed oil, maize germ oil, tea oil, SIMMONDSIA CHINENSIS SEED OIL and optional auxiliary agent are uniformly mixed, and obtain anti-acne compound essence
Oil formulation.
9. the preparation method of anti-acne compound essential oil preparation according to claim 8, which is characterized in that first by grape seed oil,
Maize germ oil, tea oil and SIMMONDSIA CHINENSIS SEED OIL are uniformly mixed, and sequentially add snake oil, Forsythia suspense essential oil, dandelion essential oil, schizonepeta essence
Oil, grass-leaved sweetflag essential oil, Lavender, frutus cnidii essential oil, Peppermint essential oil and optional auxiliary agent are uniformly mixed.
10. according to application of the claim 1-7 any one of them anti-acne compound essential oil preparations in skin care item.
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| WO2020097982A1 (en) * | 2018-11-15 | 2020-05-22 | 广东轻工职业技术学院 | Essential oil composition for scalp care and use |
| CN111870557A (en) * | 2020-08-31 | 2020-11-03 | 海口植之素生物资源研究所有限公司 | Coconut oil based antibacterial and anti-inflammatory cleansing oil and preparation method thereof |
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Effective date of registration: 20230118 Address after: 4-5/F, Building 1, Xinqizhou Public R&D Center, Chuangcheng, Department of Traditional Chinese Medicine, Ganjiang New District, Nanchang City, Jiangxi Province, 330000 Patentee after: Jiangxi Guxiang jinyunda Health Industry Co.,Ltd. Address before: 330000 no.1688 Meiling Avenue, Wanli District, Nanchang City, Jiangxi Province Patentee before: JIANGXI University OF TRADITIONAL CHINESE MEDICINE |
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