CN105581924A - Compound cassia oil nanoemulsion and preparation method thereof - Google Patents
Compound cassia oil nanoemulsion and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of cosmetics, in particular to a compound cassia oil nanoemulsion and a preparation method thereof. The compound cassia oil nanoemulsion comprises vegetable oil, organic materials, deionized water and auxiliary materials, wherein the vegetable oil comprises cassia oil, Elaeagnus mollis diel oil and peppermint oil; the organic materials comprise alkyl polyglycoside and 1,2-propylene glycol; the auxiliary materials comprise caprylic/capric triglyceride, SCY, vitamin E, Dermosoft Eco 1388 and citric acid. The compound cassia oil nanoemulsion has remarkable mosquito bite resistance, itching relief and anti-inflammation treatment effects, the used materials are environment-friendly, the preparation method is simple and convenient, a preparation is stable, and suitability for industrial production can be realized.
Description
Technical field
The invention belongs to cosmetic field, be specially a kind of compound cassia oil nano-emulsion and preparation method thereof, this nano-emulsion main component is combined by extract cassia oil, samara oil, the peppermint oil of pure natural plant, can prevent bite by mosquitos, and skin is smeared and can be played itch stopping and diminish inflammation effect after by bite by mosquitos.
Background technology
Bite by mosquitos usually causes the itch of local skin and swells and ache, and easily brings out inflammation, i.e. insect bite dermatitis, and Chang Yin scratches and the suppurative dermatosis such as secondary pustule sore. At present, the traditional treatment of insect dermatitis mainly contains: 1. and for oral administration, be mainly diphenhydramine, phenergan, chlorpheniramine, hormone, and use vitamin C or cobalamin and the therapeutic alliance of antihistaminic medicine; 2. external application, suits the medicine to the illness and disposes, and as selected, floral water, essential wind oil etc. are outer puts on the skin. And that these traditional therapies exist side effect is large, the shortcoming of poor effect.
Summary of the invention
The object of this invention is to provide that a kind of mosquito control is bitten, the significant compound cassia oil of relieving itching and eliminating swelling effect nano-emulsion and preparation method thereof. The present invention is by the screening reasonable formula to pure natural plant oil, select surfactant and the cosurfactant of nontoxic green, determine the ratio of the each component of emulsion by pseudo-ternary phase diagram, and verify curative effect by animal experiment, with the compound cassia oil nano-emulsion that preparation quality is stable, effect is lasting, security is good.
The present invention adopts following technical scheme to realize: a kind of compound cassia oil nano-emulsion, formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 1～6:1～4:2～5 configuration, it is 2.0%～8.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 4～6:1～2 configuration, 2-propane diols, it is 30%～40% that organic materials accounts for nano-emulsion percentage by weight; It is 35%～45% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 2.0%～6.0% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 0.5%～5.0% that SCY accounts for nano-emulsion percentage by weight, it is 0.05%～0.2% that vitamin E accounts for nano-emulsion percentage by weight, it is 3.0%～5.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 10%～20% that citric acid accounts for nano-emulsion percentage by weight.
The preparation method of above-mentioned compound cassia oil nano-emulsion, comprises the following steps:
The first step: be that 1～6:1～4:2～5 take by cassia oil, samara oil, peppermint oil according to weight part ratio, then mix, stir, then add successively caprylic/capric triglyceride and vitamin E, stir, obtain A phase; Be that 4～6:1～2 take by APG, 1,2-PD according to weight part ratio, then mix, stir, obtain B phase; By A join while stirring mutually B mutually in and stir, obtain A/B phase; More than preparation can, at 20 DEG C～30 DEG C, be carried out under the stirring condition that rotating speed is 800rpm～1200rpm;
Second step: it is even that the SCY that takes prescription amount joins deionized water for stirring, obtains C phase, and the amount of deionized water used is 3/4 of deionized water full dose; By C at 25 DEG C～35 DEG C, under the stirring condition that rotating speed is 1500rpm～3000rpm, slowly join equably above-mentioned A/B mutually in, more slowly drip DermosoftEco1388, continue to stir 5～10min and become yellow clear and bright shape emulsion to system, obtain D phase;
The 3rd step: take citric acid be dissolved in D mutually in, finally add pure residue deionized water, stir, regulate pH to 5.0～6.0 of D phase, make compound cassia oil nano-emulsion.
Pure natural plant extract cassia oil has pharmacologically active widely, especially there is larger value at anti-inflammation, desinsection expelling parasite, the aspect such as anti-oxidant, cassia oil all has stronger inhibitory action to common bacteria, saccharomycete, mould, and in gas phase diffusion bacteriostatic experiment, fungistatic effect is still comparatively obvious; Cassia oil is a kind of effectively free radical scavenger, and grease is also had to good antioxidation, and its oxidation resistance is more effective than 0.05%Vc. Vitamin E Wheat Protein in samara oil, delays cell aging because of oxidation, promotes the circulation of skin capilary, keeps skin elasticity, can prevent skin scar; The another moisture that pins, has deep skin " NMF " good reputation; Level and smooth skin, reduces skin antiinflammation. Peppermint oil have obviously the multiple actions, particularly result of the test such as antipruritic, antibacterial, antiviral and mosquito repellent show human body smear peppermint oil night average energy drive away 85% all kinds of mosquitoes; The antibacterial action that peppermint oil has had, have again the curative effects such as purifying skin, Bergamot Mint Extract, contraction capilary, and transdermal effect is good, is widely used at present beauty industry.
Nano-emulsion is a kind of new form of administration, its steady quality, and rapidly, the reduction toxic and side effect that can heighten the effect of a treatment, has powerful advantage at transdermal drug delivery system for strong permeability and absorption. Plant extracts, especially essential oil high volatility, stability is low, and effect can be influenced. But, after nano-emulsion system is coated, there is the advantages such as high density, strong infiltration, easily absorption, stability, nano-emulsion is prepared under the condition of 25 DEG C of left and right in addition, do not affect its content and activity, the concentration of functional component in the fine droplet of nano-emulsion can reach very high, and natural essential oil functional component forms interfacial film by surfactant molecule fast, can form rapidly functional component gradient penetration bank at skin surface, reach the feature that makes the efficient effect of natural essential oil and slowly-releasing, maintain effect permanent.
The present invention is exactly according to the efficacy effect of cassia oil, samara oil, peppermint oil, is made into nano-emulsion, plays the efficacy effect of the pruitus that prevents bite by mosquitos and bite by mosquitos is caused, redness, even inflammation and pain. Because the volatile oil medicine utmost point is insoluble in water, poor stability, be easy to scatter and disappear, affect drug effect, be made into after O/W type nano-emulsion, can prevent drug volatilization, oxidation, improve stability, improve drug effect, reach slowly-releasing or target administration object, the novel form of the treatment of red swelling of the skin bite by mosquitos being caused for the market development is a kind of and prevention more remarkable treatment effect.
The innovative point of patent of the present invention is: 1. select pure natural plant oil cassia oil, samara oil, peppermint oil prescription, the antipruritic analgesic activity after both having played mosquito proof and biting and bite, again to human body have no side effect, nonirritant. Cassia oil, except aforesaid antibacterial action, also has certain analgesic activity; Peppermint oil not only can be driven away mosquito, and effective kill mosquitoes larva, and has significantly refrigerant antipruritic and certain anti-inflammatory and analgesic effect; Add the significant skin care effect of samara oil, three's compatibility effect is splendid.
2. APG (APG) is the product that glucose and natural fatty alcohol generate, easily biological-degradable, nontoxic, non-stimulated, pollution-free, be " green " surfactant, surface property is good, reduce surface tension strong, emulsibility, good dispersion, be extensively used as the functional products such as washing, emulsification, solubilising, moisturizing, not only surface tension is low for it, foam enriches fine and smooth and stablizes, and decontamination is good, and compatibility is splendid. It is unique kind that really can deserve to be called " world-class " surfactant. Unique superior function of the APG making due to pure natural raw material, the novel cosmetic of making as active component with APG has both at home and abroad shown good skin moisture-keeping and skin care performance. Aspect food emulsifying agent, APG, compared with same food emulsifying agent (as glycerine fatty acid), has same or analogous character. Not only solve the problem that China's food emulsifying agent only has lipophile (HLB5-9) product using APG as food emulsifying agent, also increased the kind of food emulsifying agent.
3. compound cassia bark nano-emulsion of the present invention, because fine droplet is strong permeability, has easy absorption, strengthens the advantage of effect, reduction toxic and side effect, plays and prevents bite by mosquitos and bite the pruitus, redness, the even effect of inflammation that cause.
Brief description of the drawings
Fig. 1 is compound cassia oil nano-emulsion aspect graph under transmission electron microscope.
Fig. 2 is compound cassia oil nano-emulsion particle diameter distribution map.
Fig. 3 is compound cassia oil nano-emulsion zata potential image.
Detailed description of the invention
Embodiment mono-:
A kind of compound cassia oil nano-emulsion, formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 1:2:5 configuration, it is 4.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 4:2 configuration, 2-propane diols, it is 40% that organic materials accounts for nano-emulsion percentage by weight; It is 35% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 2.0% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 0.8% that SCY accounts for nano-emulsion percentage by weight, it is 0.2% that vitamin E accounts for nano-emulsion percentage by weight, it is 3.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 15% that citric acid accounts for nano-emulsion percentage by weight.
Embodiment bis-:
A kind of compound cassia oil nano-emulsion, it is characterized in that being formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 2:4:2 configuration, it is 6.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 5:1 configuration, 2-propane diols, it is 35% that organic materials accounts for nano-emulsion percentage by weight; It is 40% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 4.0% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 0.9% that SCY accounts for nano-emulsion percentage by weight, it is 0.1% that vitamin E accounts for nano-emulsion percentage by weight, it is 4.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 10% that citric acid accounts for nano-emulsion percentage by weight.
Embodiment tri-:
A kind of compound cassia oil nano-emulsion, it is characterized in that being formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 4:2:2 configuration, it is 2.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 6:1 configuration, 2-propane diols, it is 30% that organic materials accounts for nano-emulsion percentage by weight; It is 45% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 6.0% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 0.5% that SCY accounts for nano-emulsion percentage by weight, it is 0.05% that vitamin E accounts for nano-emulsion percentage by weight, it is 5.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 11.45% that citric acid accounts for nano-emulsion percentage by weight.
Embodiment tetra-:
A kind of compound cassia oil nano-emulsion, it is characterized in that being formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 6:1:3 configuration, it is 8.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 6:2 configuration, 2-propane diols, it is 30% that organic materials accounts for nano-emulsion percentage by weight; It is 35% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 2.85% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 1.0% that SCY accounts for nano-emulsion percentage by weight, it is 0.15% that vitamin E accounts for nano-emulsion percentage by weight, it is 3.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 20% that citric acid accounts for nano-emulsion percentage by weight.
Embodiment five:
A kind of compound cassia oil nano-emulsion, it is characterized in that being formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 4:2:3 configuration, it is 4.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 4:1 configuration, 2-propane diols, it is 35% that organic materials accounts for nano-emulsion percentage by weight; It is 35% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 2.8% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 5.0% that SCY accounts for nano-emulsion percentage by weight, it is 0.2% that vitamin E accounts for nano-emulsion percentage by weight, it is 3.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 15% that citric acid accounts for nano-emulsion percentage by weight.
Embodiment six:
A kind of compound cassia oil nano-emulsion, it is characterized in that being formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 6:2:2 configuration, it is 8.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 5:2 configuration, 2-propane diols, it is 30% that organic materials accounts for nano-emulsion percentage by weight; It is 40% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 3.8% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 3.0% that SCY accounts for nano-emulsion percentage by weight, it is 0.2% that vitamin E accounts for nano-emulsion percentage by weight, it is 5.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 10% that citric acid accounts for nano-emulsion percentage by weight.
The preparation method of above-mentioned compound cassia oil nano-emulsion, comprises the following steps:
The first step: be that 1～6:1～4:2～5 take by cassia oil, samara oil, peppermint oil according to weight part ratio, then mix, stir, then add successively caprylic/capric triglyceride and vitamin E, stir, obtain A phase; Be that 4～6:1～2 take by APG, 1,2-PD according to weight part ratio, then mix, stir, obtain B phase; By A join while stirring mutually B mutually in and stir, obtain A/B phase; More than preparation can, at 20 DEG C～30 DEG C, be carried out under the stirring condition that rotating speed is 800rpm～1200rpm;
Second step: it is even that the SCY that takes prescription amount joins deionized water for stirring, obtains C phase, and the amount of deionized water used is 3/4 of deionized water full dose; By C at 25 DEG C～35 DEG C, under the stirring condition that rotating speed is 1500rpm～3000rpm, slowly join equably above-mentioned A/B mutually in, more slowly drip DermosoftEco1388, continue to stir 5～10min and become yellow clear and bright shape emulsion to system, obtain D phase;
The 3rd step: take citric acid be dissolved in D mutually in, finally add pure residue deionized water, stir, regulate pH to 5.0～6.0 of D phase, make compound cassia oil nano-emulsion.
1. the itching-relieving action of compound cassia bark nano-emulsion is investigated
Choose healthy mice and be divided at random 3 groups, be i.e. common newborn group of blank group, compound cassia bark nano-emulsion group, compound cassia bark. Shave hair-fields coating 1 time at mouse part skin for every group. After administration, 30min is in shaving hair place's hypodermic injection to 4-aminopyridine, and blank group is injected isometric(al) physiological saline. Record each treated animal number of times of Licking response in 10min after injection 4-AP. Data acquisition SPSS11.0 analysis software. Result of the test is in table 1.
The antipruritic result of the test of table 1 compound cassia bark nano-emulsion
From table 1, the common newborn group of inhibiting rate to the mouse itch that 4-aminopyridine is caused of compound cassia bark nano-emulsion group, compound cassia bark is respectively 55.88% and 32.35%, and the antipruritic effect of visible compound cassia bark nano-emulsion group is obviously better than common newborn group of compound cassia bark.
2. the antiinflammatory action of compound cassia bark nano-emulsion
Choose healthy mice and be divided at random 3 groups, be i.e. common newborn group of blank group, compound cassia bark nano-emulsion group, compound cassia bark. Mouse left and right ear is taking dimethylbenzene as proinflammatory agent. Each group of medicine is evenly applied to respectively to two sides, ear front and back, mouse left and right, and 1h is administered once, successive administration 8h. Taking dimethylbenzene as proinflammatory agent, after last administration 1h, by mouse etherization, at the front and back of every mouse right ear two sided coatings proinflammatory agent 0.02ml, left ear compares. Taking the weight differential of two auricles as swelling, calculate inhibitory rate of intumesce [inhibiting rate (%)=(blank group swelling one experimental group swelling)/blank group swelling × 100%]. Adopt the statistical analysis of SPSSll.0 analysis software, the results are shown in Table 2.
Table 2 compound cassia bark nano-emulsion is investigated the antiinflammatory action of mouse
From table 2, compound cassia bark nano-emulsion and the common breast of compound cassia bark all can suppress the mice ear due to dimethylbenzene, and inhibiting rate is respectively 87.0% and 71.9%, and blank group is without obvious antiphlogistic effects. The antiphlogistic effects of visible compound cassia bark nano-emulsion is better than the common breast of compound cassia bark.
Inflammation is the reaction of biological tissue to local damage with vascular system. Early stage in inflammation, some inflammatory mediator stimulates blood vessel, distend the blood vessels, blood vessel endothelium gap enlargement, Vascular Permeability strengthens, liquid in blood plasma, protein and leucocyte etc. are exuded to tissue space, along with the increase of oozing out, cause swollen tissue, therefore, to ooze out swollen tissue be the early stage important indicator of inflammation to inflammatory. Inflammatory mediator refers to that one group under pro-inflammatory cytokine effect, the participation inflammatory reaction that produces and discharge by local organization or blood plasma, and there is the chemically reactive substance of proinflammatory effect. Be divided into two classes by its source, one class is that pro-inflammatory cytokine directly or indirectly acts on the histocytes such as leucocyte, mast cell, macrophage and blood platelet, make it the tissues-derived inflammatory mediator generating, as histamine, prostaglandin, leukotriene, lysosome composition and lymphokine etc.; One class is the source plasma inflammatory mediator from blood plasma components. Mice caused by dimethylbenzene xylene auricle edema is selected in the present invention test, and the antiinflammatory action result of having studied the inflammation that compound cassia bark nano-emulsion causes tissues-derived inflammatory mediator shows, compound cassia bark nano-emulsion has significant antiinflammatory action.
In a word, compound cassia bark nano-emulsion of the present invention has the antipruritic and anti-inflammatory treatment effect of significant anti-bite by mosquitos, and material therefor environmental protection, and preparation method is easy, preparation stabilization, the suitable suitability for industrialized production that realizes.
Claims (2)
1. a compound cassia oil nano-emulsion, it is characterized in that being formed by vegetable oil, organic materials, deionized water and auxiliary material, wherein vegetable oil comprises according to weight part ratio being cassia oil, samara oil, the peppermint oil of 1 ~ 6:1 ~ 4:2 ~ 5 configuration, it is 2.0% ~ 8.0% that vegetable oil accounts for nano-emulsion percentage by weight, organic materials comprises according to weight part ratio being the APG, 1 of 4 ~ 6:1 ~ 2 configuration, 2-propane diols, it is 30% ~ 40% that organic materials accounts for nano-emulsion percentage by weight; It is 35% ~ 45% that deionized water accounts for nano-emulsion percentage by weight; Auxiliary material comprises caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, it is 2.0% ~ 6.0% that caprylic/capric triglyceride accounts for nano-emulsion percentage by weight, it is 0.5% ~ 5.0% that SCY accounts for nano-emulsion percentage by weight, it is 0.05% ~ 0.2% that vitamin E accounts for nano-emulsion percentage by weight, it is 3.0% ~ 5.0% that DermosoftEco1388 accounts for nanoemulsion weight ratio, and it is 10% ~ 20% that citric acid accounts for nano-emulsion percentage by weight.
2. a preparation method for compound cassia oil nano-emulsion as claimed in claim 1, is characterized in that comprising the following steps:
The first step: be that 1 ~ 6:1 ~ 4:2 ~ 5 take by cassia oil, samara oil, peppermint oil according to weight part ratio, then mix, stir, then add successively caprylic/capric triglyceride and vitamin E, stir, obtain A phase; Be that 4 ~ 6:1 ~ 2 take by APG, 1,2-PD according to weight part ratio, then mix, stir, obtain B phase; By A join while stirring mutually B mutually in and stir, obtain A/B phase; More than prepare at 20 DEG C ~ 30 DEG C, under the stirring condition that rotating speed is 800rpm ~ 1200rpm, carry out;
Second step: it is even that the SCY that takes prescription amount joins deionized water for stirring, obtains C phase, and the amount of deionized water used is 3/4 of deionized water full dose; By C at 25 DEG C ~ 35 DEG C, under the stirring condition that rotating speed is 1500rpm ~ 3000rpm, slowly join equably above-mentioned A/B mutually in, more slowly drip DermosoftEco1388, continue to stir 5 ~ 10min and become yellow clear and bright shape emulsion to system, obtain D phase;
The 3rd step: take citric acid be dissolved in D mutually in, finally add pure residue deionized water, stir, regulate pH to 5.0 ~ 6.0 of D phase, make compound cassia oil nano-emulsion.
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| CN106214745A (en) * | 2016-08-31 | 2016-12-14 | 防城港市防城区那梭香料厂 | A kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof |
| CN110548164A (en) * | 2019-10-24 | 2019-12-10 | 南京启景环境科技有限公司 | Plant extraction compound nano material for air purification |
| CN112156053A (en) * | 2020-10-22 | 2021-01-01 | 北京中康联健康科技有限公司 | European cowberry fruit water-luster composition and preparation method thereof |
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| CN106214745A (en) * | 2016-08-31 | 2016-12-14 | 防城港市防城区那梭香料厂 | A kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof |
| CN110548164A (en) * | 2019-10-24 | 2019-12-10 | 南京启景环境科技有限公司 | Plant extraction compound nano material for air purification |
| CN112156053A (en) * | 2020-10-22 | 2021-01-01 | 北京中康联健康科技有限公司 | European cowberry fruit water-luster composition and preparation method thereof |
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| CN105581924B (en) | 2019-01-04 |
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