CN106214745A - A kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof - Google Patents

A kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof Download PDF

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CN106214745A
CN106214745A CN201610796992.2A CN201610796992A CN106214745A CN 106214745 A CN106214745 A CN 106214745A CN 201610796992 A CN201610796992 A CN 201610796992A CN 106214745 A CN106214745 A CN 106214745A
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parts
oleum cinnamomi
phase
emulsion
nano
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陈猛棠
陈相棠
周丽珠
李军集
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FANGCHENGGANG FANGCHENG DISTRICT NASUO PERFUME FACTORY
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FANGCHENGGANG FANGCHENG DISTRICT NASUO PERFUME FACTORY
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/20—Aceraceae (Maple family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
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Abstract

The present invention relates to a kind of medicine, be specially a kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof, be made up of vegetable oil, organic materials, deionized water and adjuvant；Adjuvant includes xanthan gum, vitamin E, citric acid；Each raw material weight number is, vegetable oil 4.0 parts～8.0 parts, organic materials 35 parts～40 parts；Deionized water 35 parts～45 parts；Xanthan gum 3.0 parts～6.0 parts, vitamin E 0.05 part～0.12 part, citric acid 10 parts～20 parts；Selection pure natural plant oil, had both played the antipruritic analgesic activity after mosquito proof is bitten and bitten, again to human non-toxic's side effect, nonirritant.Oleum Cinnamomi is except aforesaid antibacterial action, the most certain analgesic activity；Owing to fine droplet is strong permeability, there is easily absorption, strengthen effect, the advantage of reduction toxic and side effects, play and prevent mosquito bite and bite skin pruritus, the effect of redness, even inflammation caused.

Description

A kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof
Technical field
The present invention relates to a kind of medicine, be specially a kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof.
Background technology
Mosquito bite usually causes the pruritus of local skin and swells and ache, and easily induces inflammation, i.e. insect bite dermatitis, and Chang Yin scratches Grab and the suppurative dermatosis such as secondary pustule skin ulcer.At present, the traditional treatment of insect dermatitis mainly has: 1. for oral administration, mainly benzene sea Lamine, promethazine, chlorphenamine, hormone, and use vitamin C or vitamin B12 and antihistaminic medicine therapeutic alliance；2. outside With, suit the medicine to the illness and dispose, as selected, floral water, essential balm etc. are outer to be put on the skin.And these traditional therapies also exist side effect greatly, effect is not Good shortcoming.
Summary of the invention
It is an object of the invention to provide a kind of mosquito control bite, relieving itching and eliminating swelling effect significant compound recipe Oleum Cinnamomi nano-emulsion And preparation method thereof.
The present invention, by the screening reasonable formula to pure natural plant oil, selects the surfactant of nontoxic green and helps table Face activating agent, is determined the ratio of each component of Emulsion, and verifies curative effect by animal experiment, to prepare quality by pseudo-ternary phase diagram The compound recipe Oleum Cinnamomi nano-emulsion stable, effect is lasting, safety is good.
The present invention adopts the following technical scheme that realization:
A kind of compound recipe Oleum Cinnamomi nano-emulsion, is made up of vegetable oil, organic materials, deionized water and adjuvant；Adjuvant includes Huang Virgin rubber, vitamin E, citric acid；Each raw material weight number is, vegetable oil 4.0 parts～8.0 parts, organic materials 35 parts～40 parts；Go Ionized water 35 parts～45 parts；Xanthan gum 3.0 parts～6.0 parts, vitamin E 0.05 part～0.12 part, citric acid 10 parts～20 parts；
Wherein vegetable oil include according to weight part ratio be 1～6: 1～4: 2～5 configuration Oleum Cinnamomis, Acer Truncatum Buge seed oil, Eucommia ulmoides seed oil；
Organic materials includes that according to weight part ratio be the Coco-Glucoside of 4～6: 1～2 configurations, glycerol.
The preparation method of a kind of compound recipe Oleum Cinnamomi nano-emulsion, comprises the following steps:
(1) Oleum Cinnamomi, Acer Truncatum Buge seed oil, eucommia ulmoides seed oil are weighed according to weight part ratio, then mix, stir, then It is sequentially added into xanthan gum and vitamin E, stirs, obtain A phase；Coco-Glucoside, glycerol are claimed according to weight part ratio 2 Take, then mix, stir, obtain B phase；A phase joined in B phase while stirring and stirs, obtaining A/B phase；With Upper preparation at 20 DEG C～30 DEG C, rotating speed be 800rpm～1200rpm stirring condition under carry out；
(2) stirring during citric acid joins deionized water, rotating speed is under the stirring condition of 1500rpm～3000rpm Slowly it is homogeneously added in above-mentioned A/B phase and stirs, regulate pH to 5.0～6.0, i.e. prepare compound recipe Oleum Cinnamomi nano-emulsion.
A kind of compound recipe Oleum Cinnamomi nano-emulsion that the present invention provides and preparation method thereof, selects pure natural plant oil, both played Mosquito proof bite and bite after antipruritic analgesic activity, again to human non-toxic's side effect, nonirritant.Oleum Cinnamomi is except aforesaid Antibacterial action, the most certain analgesic activity；Owing to fine droplet is strong permeability, having easily absorption, enhancing effect, reduction poison are secondary The advantage of effect, plays and prevents mosquito bite and bite skin pruritus, the effect of redness, even inflammation caused.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, but the present invention is not limited only to these embodiments, not On the premise of departing from present inventive concept, within any improvement made all falls within protection scope of the present invention.
A kind of compound recipe Oleum Cinnamomi nano-emulsion, is made up of vegetable oil, organic materials, deionized water and adjuvant；Adjuvant includes Huang Virgin rubber, vitamin E, citric acid；Each raw material weight number is, vegetable oil 4.0 parts～8.0 parts, organic materials 35 parts；Deionized water 45 parts；Xanthan gum 3.0 parts, vitamin E 0.05 part, citric acid 10 parts；
Wherein vegetable oil includes that according to weight part ratio be the Oleum Cinnamomi of 1: 4: 5 configuration, Acer Truncatum Buge seed oil, eucommia ulmoides seed oil；
Organic materials includes that according to weight part ratio be the Coco-Glucoside of 6: 1 configurations, glycerol.
The preparation method of a kind of compound recipe Oleum Cinnamomi nano-emulsion, comprises the following steps:
(1) Oleum Cinnamomi, Acer Truncatum Buge seed oil, eucommia ulmoides seed oil are weighed according to weight part ratio, then mix, stir, then It is sequentially added into xanthan gum and vitamin E, stirs, obtain A phase；Coco-Glucoside, glycerol are claimed according to weight part ratio 2 Take, then mix, stir, obtain B phase；A phase joined in B phase while stirring and stirs, obtaining A/B phase；With Upper preparation at 20 DEG C～30 DEG C, rotating speed be 800rpm～1200rpm stirring condition under carry out；
(2) stirring during citric acid joins deionized water, rotating speed is under the stirring condition of 1500rpm～3000rpm Slowly it is homogeneously added in above-mentioned A/B phase and stirs, regulate pH to 5.0～6.0, i.e. prepare compound recipe Oleum Cinnamomi nano-emulsion.
Embodiment 2
A kind of compound recipe Oleum Cinnamomi nano-emulsion, is made up of vegetable oil, organic materials, deionized water and adjuvant；Adjuvant includes Huang Virgin rubber, vitamin E, citric acid；Each raw material weight number is, vegetable oil 4.0 parts～8.0 parts, organic materials 40 parts；Deionized water 35 parts；Xanthan gum 6.0 parts, vitamin E 0.12 part, citric acid 20 parts；
Wherein vegetable oil includes that according to weight part ratio be the Oleum Cinnamomi of 6: 1: 2 configurations, Acer Truncatum Buge seed oil, eucommia ulmoides seed oil；
Organic materials includes that according to weight part ratio be the Coco-Glucoside of 4: 2 configurations, glycerol.
The preparation method of a kind of compound recipe Oleum Cinnamomi nano-emulsion, comprises the following steps:
(1) Oleum Cinnamomi, Acer Truncatum Buge seed oil, eucommia ulmoides seed oil are weighed according to weight part ratio, then mix, stir, then It is sequentially added into xanthan gum and vitamin E, stirs, obtain A phase；Coco-Glucoside, glycerol are claimed according to weight part ratio 2 Take, then mix, stir, obtain B phase；A phase joined in B phase while stirring and stirs, obtaining A/B phase；With Upper preparation at 20 DEG C～30 DEG C, rotating speed be 800rpm～1200rpm stirring condition under carry out；
(2) stirring during citric acid joins deionized water, rotating speed is under the stirring condition of 1500rpm～3000rpm Slowly it is homogeneously added in above-mentioned A/B phase and stirs, regulate pH to 5.0～6.0, i.e. prepare compound recipe Oleum Cinnamomi nano-emulsion.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that, for those of ordinary skill in the art For, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the guarantor of the present invention Protect scope.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.

Claims (2)

1. a compound recipe Oleum Cinnamomi nano-emulsion, it is characterised in that be made up of vegetable oil, organic materials, deionized water and adjuvant；Auxiliary Material includes xanthan gum, vitamin E, citric acid；Each raw material weight number is, vegetable oil 4.0 parts～8.0 parts, organic materials 35 parts ～40 parts；Deionized water 35 parts～45 parts；Xanthan gum 3.0 parts～6.0 parts, vitamin E 0.05 part～0.12 part, citric acid 10 parts ～20 parts；
Wherein vegetable oil includes that according to weight part ratio be the Oleum Cinnamomi of 1～6: 1～4: 2～5 configurations, Acer Truncatum Buge seed oil, the Cortex Eucommiae Seed oil；
Organic materials includes that according to weight part ratio be the Coco-Glucoside of 4～6: 1～2 configurations, glycerol.
The preparation method of a kind of compound recipe Oleum Cinnamomi nano-emulsion the most according to claim 1, it is characterised in that include following step Rapid:
(1) Oleum Cinnamomi, Acer Truncatum Buge seed oil, eucommia ulmoides seed oil are weighed according to weight part ratio, then mix, stir, more successively Add xanthan gum and vitamin E, stir, obtain A phase；Coco-Glucoside, glycerol are weighed according to weight part ratio 2, Then mix, stir, obtain B phase；A phase joined in B phase while stirring and stirs, obtaining A/B phase；More than make Standby at 20 DEG C～30 DEG C, rotating speed be 800rpm～1200rpm stirring condition under carry out；
(2) stir during citric acid joins deionized water, rotating speed be 1500rpm～3000rpm stirring condition under slowly It is homogeneously added in above-mentioned A/B phase and stirs, regulate pH to 5.0～6.0, i.e. prepare compound recipe Oleum Cinnamomi nano-emulsion.
CN201610796992.2A 2016-08-31 2016-08-31 A kind of compound recipe Oleum Cinnamomi nano-emulsion and preparation method thereof Pending CN106214745A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107049948A (en) * 2017-01-20 2017-08-18 谭正杰 Acer truncatum essential oil aerosol
CN111150706A (en) * 2020-02-28 2020-05-15 深圳市金枫生物医药科技有限公司 Submicron emulsion containing acer truncatum seed oil and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102813615A (en) * 2012-08-25 2012-12-12 昆明海之灵生物科技开发有限公司 Acer Trunctum Bunge Chinese medicinal herb lipstick and preparation method thereof
CN104224925A (en) * 2014-10-09 2014-12-24 无限极（中国）有限公司 Mosquito repellent and itching relieving traditional Chinese medicine composition and application thereof
CN105581924A (en) * 2015-12-24 2016-05-18 山西琪尔康翅果生物制品有限公司 Compound cassia oil nanoemulsion and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102813615A (en) * 2012-08-25 2012-12-12 昆明海之灵生物科技开发有限公司 Acer Trunctum Bunge Chinese medicinal herb lipstick and preparation method thereof
CN104224925A (en) * 2014-10-09 2014-12-24 无限极（中国）有限公司 Mosquito repellent and itching relieving traditional Chinese medicine composition and application thereof
CN105581924A (en) * 2015-12-24 2016-05-18 山西琪尔康翅果生物制品有限公司 Compound cassia oil nanoemulsion and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107049948A (en) * 2017-01-20 2017-08-18 谭正杰 Acer truncatum essential oil aerosol
CN111150706A (en) * 2020-02-28 2020-05-15 深圳市金枫生物医药科技有限公司 Submicron emulsion containing acer truncatum seed oil and preparation method thereof

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Application publication date: 20161214