CN106806713A - A kind of Chinese and Western for alleviating periostitis symptom combines medicine oil and preparation method thereof - Google Patents

A kind of Chinese and Western for alleviating periostitis symptom combines medicine oil and preparation method thereof Download PDF

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CN106806713A
CN106806713A CN201710162389.3A CN201710162389A CN106806713A CN 106806713 A CN106806713 A CN 106806713A CN 201710162389 A CN201710162389 A CN 201710162389A CN 106806713 A CN106806713 A CN 106806713A
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oil
chinese
medicine
western
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栾瑞玲
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract

Medicine oil and preparation method thereof is combined the present invention relates to a kind of Chinese and Western for alleviating periostitis symptom, belongs to topical drug technical field.A kind of Chinese and Western for alleviating periostitis symptom combines medicine oil, is made up of following raw materials：58 140 parts of Chinese medicine composition, 22 70 parts of Western medicine compound, 8 14 parts of rhododendron anthopogonoide, 42 60 parts of methyl alcohol, 33 42 parts of ether, 80 120 parts of peppermint oil, 280 500 parts of wintergreen, 30 55 parts of Seabuckthorn Oil, 8 15 parts of volatile oil extracted from eucalyptus' leaves or twigs, 15 32 parts of essential oil, 28 parts of assistant for emulsifying agent.A kind of Chinese and Western for alleviating periostitis symptom of the invention combines medicine oil, formed with Multiple components configuration, site of disease is smeared by external application and is equipped with massage, the effects such as blood circulation being effectively promoted, is softened connective tissue, eliminated oedema, degerming throe, recover function of joint, and may also operate as avoiding more infectious-related complication, the effect of reduction amyotrophia.

Description

A kind of Chinese and Western for alleviating periostitis symptom combines medicine oil and preparation method thereof
Technical field
Medicine oil and preparation method thereof is combined the present invention relates to a kind of Chinese and Western for alleviating periostitis symptom, belongs to topical drug skill Art field.
Background technology
Periostitis is that, due to periosteum and periosteal vessels expansion, congested, oedema or subperiosteal hemorrhage, organization of hematoma, periosteum increases Raw and inflammation sexually revises the infectious periosteum injury that the stress periosteum injury that causes or suppurative bacterium invasion and attack are caused.Mainly Because usually sports are few, the human body coordination ability is poor, and motion is increased suddenly, and training is run and jumped, and the activity time is long to skip in race Foot is pedaled after exerting oneself repeatedly in journey, and Calf muscle is alternately in tension for a long time, and muscle is constantly involved, and makes shank tibiofibula film Tear damage, periosteum and periosteal vessels dilatation and congestion oedema or subperiosteal hemorrhage organization of hematoma, periosteal proliferation and inflammation are sexually revised. Treatment means main at present are the maintenances for giving antibiotic therapy and later stage of early stage, but due to the characteristic of periostitis, It is typically difficult thoroughly healing, it is important to carry out daily health care.Therefore can have it is a kind of can both play therapeutic action, again can be with The medicine for playing later stage health-care efficacy is necessary.
The content of the invention
It is an object of the invention to solve the weak point that above-mentioned prior art is present, there is provided one kind can eliminate oedema, Reduction pain, the Chinese and Western of the alleviation periostitis symptom for stimulating circulation combine medicine oil and preparation method thereof, and can be effective Reduction heal infectious-related complication generation.
The present invention is achieved by the following technical solutions：
A kind of Chinese and Western for alleviating periostitis symptom combines medicine oil, and it is characterized in that by following raw materials system Into：Chinese medicine composition 58-140 parts, Western medicine compound 22-70 parts, rhododendron anthopogonoide 8-14 parts, methyl alcohol 42-60 parts, ether 33-42 Part, peppermint oil 80-120 parts, wintergreen 280-500 parts, Seabuckthorn Oil 30-55 parts, volatile oil extracted from eucalyptus' leaves or twigs 8-15 parts, essential oil 15-32 parts, help emulsification Agent 2-8 parts, suspension stabilizer 0.8-1.5 parts, 45-80 parts, preservative 0.08-0.4 parts of moisturizing grease；
The Chinese medicine composition is by Chinese juniper 3-6 parts, Sievers wormwood 2-6 parts, monkshood 4-8 parts, German tamarisk 2-5 parts, lamiophlomis rotata 5-9 Part, root of bidentate achyranthes 3-6 parts, dalbergia wood 4-8 parts, santal 4-8 parts, frankincense 4-8 parts, dragon's blood 3-9 parts, sunset abelmoschus seed 2-5 parts, hooker winghead root 3-9 Part, root bark of Chinese wolf-berry 3-9 parts, bark of ash 1-5 parts, west safflower 5-12 parts, rhizoma imperatae 3-8 parts, butterflybush flower 1-4 parts, borneol 5-10 parts of mixing Form；
The Western medicine compound is by paracetamol 5-20 parts, Ciprofloxacin Lactate 7-22 parts, C14H10Cl2NNaO2 10-28 parts Mix；
The essential oil is by one or more mixing in Essential Oil From Pine Needles, cinnamon essential oil, Bergamot, elemi quintessence oil Into；
The assistant for emulsifying agent is glycerine；
The suspension stabilizer is carbomer；
The moisturizing grease is dimethicone, one or more mixing in isopropyl palmitate, isopropyl myristate and Into；
The preservative is mixed by one or more in propylben, nipagin esters, phenoxetol；
Further, a kind of Chinese and Western for alleviating periostitis symptom of the invention combines medicine oil, optimal is by weight matched somebody with somebody by following The raw material of ratio is made：It is 98 parts of Chinese medicine composition, 56 parts of Western medicine compound, 11 parts of rhododendron anthopogonoide, 52 parts of methyl alcohol, 38 parts of ether, thin 100 parts of lotus oil, 380 parts of wintergreen, 42 parts of Seabuckthorn Oil, 11 parts of volatile oil extracted from eucalyptus' leaves or twigs, 23 parts of essential oil, 6 parts of assistant for emulsifying agent, suspension stabilizer 1.2 Part, 62 parts of moisturizing grease, 0.22 part of preservative；
A kind of the above Chinese and Western for alleviating periostitis symptom combines the preparation method of medicine oil, and it is characterized in that including following Step：
（1）Mixing：Peppermint oil, wintergreen, Seabuckthorn Oil, volatile oil extracted from eucalyptus' leaves or twigs are mixed in proportion, miscella is obtained；
（2）Extract：Rhododendron anthopogonoide is cleaned, dry, shredded, soak 18-23 days in methyl alcohol, stirred once per 1-2 days, then Filtering, decompression, boil off solvent, pinch molten in the hot water, are extracted respectively with ether three times, combining extraction liquid, concentration, dewaxing, obtain Extract oil；
（3）Immersion：Chinese medicine composition is gone into the removal of impurity, cleaned up, dried, steeped into step（1）Miscella in, sealing leaching Bubble 10-20 days, is filtrated to get Chinese medicine material and medicine oil；
（4）Steam oil：Take out step（3）The Chinese medicine material of immersion, is put into jacketed pan and steams fuel-displaced, obtains steam oil；
（5）Heating：Western medicine compound, suspension stabilizer are added with the water of aliquot, water is heated to 68-75 DEG C, obtains liquid；
（6）Homogeneous：By step（5）Liquid be added in vacuum homogeneous emulsifying machine with assistant for emulsifying agent, moisturizing grease and mix, at a high speed Homogeneous, obtains homogeneous oil；
（7）Remix homogeneous：By step（3）Medicine oil, step（2）Extract oil, step（4）Steam oil, step（6）Homogeneous Oil mixes with essential oil, preservative, pours into vacuum viscolizer, high speed homogenization, obtains finished product medicine oil；
（8）Packaging：Sub-bottle packaging, sealing, sterilization.
Each raw material components effect：
Rhododendron anthopogonoide：Show through institute of Materia Medica,Chinese Academy of Medical Sciences and Lanzhou medical college pharmacological screening, rhododendron anthopogonoide is extracted The chloroform and ethyl acetate extract of thing have a preferable antiinflammatory action, experiment show 1% mL/100g of anthorhododendrin 1.5 to Rats by intraperitoneal injection, can significantly reduce and cause elevated capillary permeability because of albumen injection.Anthorhododendrin is with 130 Mg/kg rats by intraperitoneal injection, continuous 7 d, can significantly inhibit swollen hyperplasia of rat granuloma hyperplasia, and 100 mg/kg dosage groups are without bright Aobvious effect.Anti-inflammatory analgesic can be played a part of in medicine oil of the invention；
Chinese medicine composition：The traditional Chinese medical science thinks that the morbidity of periostitis hinders and sudden strain of a muscle labor with the retardance of periosteum position qi and blood, blockage of main and collateral channels, qi and blood Wound is relevant, injures periosteum, causes qi and blood obstructed and pain, and heumatism is given birth to then.Chinese medicine composition of the invention passes through rational compatibility, respectively The interphase interaction of composition, can effectively act on affected part, can play qi-regulating analgesia, detumescence and promoting granulation, the hemostasis of the row stasis of blood, antibacterial Anti-inflammatory, the effect of strengthening the muscles and bones, such that it is able to promote periosteal tissue reparation, improve oedema congestive state.
Western medicine compound：Paracetamol be acetophenone amine analgesic-antipyretic, Ciprofloxacin Lactate be antimicrobial DP finish, C14H10Cl2NNaO2 primarily serves alleviation inflammation class pain, and three kinds of drug interactions can have been played in medicine oil of the invention The analgesic activity of effect；
Peppermint oil：It is mainly used in anemopyretic cold, warm disease from the beginning of, the illness such as rubella itch, stagnation of QI due to depression of the liver, in medicine oil of the invention With the effective compatibility of Chinese medicine composition, heat-clearing can be played and dissipate wind action；
Wintergreen：Be mainly used in for spraining, dampening, it is pain in the back, courbature, neuralgia, antipruritic, in medicine oil of the invention with The effective compatibility of drug composition, can play detumescence, anti-inflammatory, analgesic effect；
Seabuckthorn Oil：The main functions of prevention and health care to disease of cardiovascular system, the functions of prevention and health care to cerebrovascular system disease, To metabolism and the effect of immune system, the functions of prevention and health care to cancer, the functions of prevention and health care to respiratory disease, Protective effect, brain-tonifying effect to liver etc., with the effective compatibility of Chinese medicine composition in medicine oil of the invention, can play Treat the effect of blood stasis and swelling pain；
Volatile oil extracted from eucalyptus' leaves or twigs：It is mainly used in treatment pruitus, neuralgia etc., with the effective compatibility of Chinese medicine composition in medicine oil of the invention, Wind-expelling pain-stopping can be played a part of；
Moisturizing grease：One kind or several in dimethicone, isopropyl palmitate, isopropyl myristate selected by the present invention Plant as moisturizing grease, can effectively be contacted with hair follicle in cortex, cortex depths is penetrated into, such that it is able to the medicine in medicine oil is had Effect composition is brought into, so as to give full play to the effect of active ingredient.
A kind of Chinese and Western for alleviating periostitis symptom of the invention combines medicine oil, is formed with Multiple components configuration, by external application Smear site of disease and be equipped with massage, blood circulation can be effectively promoted, softened connective tissue, eliminated oedema, degerming throe, recovery The effects such as function of joint, and may also operate as avoiding more infectious-related complication, the effect of reduction amyotrophia.
Specific embodiment
Specific embodiment of the invention given below, for being described in further detail to composition of the invention.
Embodiment 1
A kind of Chinese and Western for alleviating periostitis symptom of the present embodiment combines medicine oil, is made up of following raw materials：Thorn 3 parts of cypress, 2 parts of Sievers wormwood, 4 parts of monkshood, 2 parts of German tamarisk, 5 parts of lamiophlomis rotata, 3 parts of the root of bidentate achyranthes, 4 parts of dalbergia wood, 4 parts of santal, 4 parts of frankincense, 3 parts of dragon's blood, 2 parts of sunset abelmoschus seed, 3 parts of hooker winghead root, 3 parts of the root bark of Chinese wolf-berry, 1 part of the bark of ash, 5 parts of west safflower, 3 parts of rhizoma imperatae, butterflybush flower 1 Part, 5 parts of borneol, 5 parts of Paracetamol, 7 parts of Ciprofloxacin Lactate, 10 parts of C14H10Cl2NNaO2,8 parts of rhododendron anthopogonoide, 42 parts of methyl alcohol, 33 parts of ether, 80 parts of peppermint oil, 280 parts of wintergreen, 30 parts of Seabuckthorn Oil, 8 parts of volatile oil extracted from eucalyptus' leaves or twigs, 15 parts of Essential Oil From Pine Needles, 2 parts of glycerine, card ripple 0.8 part of resin, 45 parts of dimethicone, 0.08 part of propylben.
Embodiment 2
A kind of Chinese and Western for alleviating periostitis symptom of the present embodiment combines medicine oil, is made up of following raw materials：Thorn 6 parts of cypress, 6 parts of Sievers wormwood, 8 parts of monkshood, 5 parts of German tamarisk, 9 parts of lamiophlomis rotata, 6 parts of the root of bidentate achyranthes, 8 parts of dalbergia wood, 8 parts of santal, 8 parts of frankincense, 9 parts of dragon's blood, 5 parts of sunset abelmoschus seed, 9 parts of hooker winghead root, 9 parts of the root bark of Chinese wolf-berry, 5 parts of the bark of ash, 12 parts of west safflower, 8 parts of rhizoma imperatae, butterflybush flower 4 Part, 10 parts of borneol, 20 parts of Paracetamol, 22 parts of Ciprofloxacin Lactate, 28 parts of C14H10Cl2NNaO2,14 parts of rhododendron anthopogonoide, methyl alcohol 60 parts, 42 parts of ether, 120 parts of peppermint oil, 500 parts of wintergreen, 55 parts of Seabuckthorn Oil, 15 parts of volatile oil extracted from eucalyptus' leaves or twigs, 8 parts of Essential Oil From Pine Needles, cinnamon spirit 8 parts of oil, 8 parts of Bergamot, 8 parts of elemi quintessence oil, 8 parts of glycerine, 1.5 parts of carbomer, 10 parts of dimethicone, palmitic acid 20 parts of isopropyl ester, 50 parts of isopropyl myristate, 0.1 part of propylben, 0.1 part of nipagin esters, 0.2 part of phenoxetol.
Embodiment 3
A kind of Chinese and Western for alleviating periostitis symptom of the present embodiment combines medicine oil, by the raw material system of following optimal proportion by weight Into：4 parts of Chinese juniper, 4 parts of Sievers wormwood, 6 parts of monkshood, 3 parts of German tamarisk, 7 parts of lamiophlomis rotata, 5 parts of the root of bidentate achyranthes, 6 parts of dalbergia wood, 6 parts of santal, frankincense 6 parts, 7 parts of dragon's blood, 4 parts of sunset abelmoschus seed, 6 parts of hooker winghead root, 6 parts of the root bark of Chinese wolf-berry, 2 parts of the bark of ash, 8 parts of west safflower, 5 parts of rhizoma imperatae, close illiteracy Spend 2 parts, 7 parts of borneol, 12 parts of paracetamol, 12 parts of Ciprofloxacin Lactate, 16 parts of C14H10Cl2NNaO2,11 parts of rhododendron anthopogonoide, 52 parts of methyl alcohol, 38 parts of ether, 100 parts of peppermint oil, 380 parts of wintergreen, 42 parts of Seabuckthorn Oil, 11 parts of volatile oil extracted from eucalyptus' leaves or twigs, 10 parts of cinnamon essential oil, olive 13 parts of face cream essential oil, 6 parts of glycerine, 1.2 parts of carbomer, 20 parts of isopropyl palmitate, 42 parts of isopropyl myristate, nipalgin 0.08 part of ester, 0.14 part of phenoxetol.
A kind of Chinese and Western for alleviating periostitis symptom of above example combines the preparation method of medicine oil, comprises the following steps：
（1）Mixing：Peppermint oil, wintergreen, Seabuckthorn Oil, volatile oil extracted from eucalyptus' leaves or twigs are mixed in proportion, miscella is obtained；
（2）Extract：Rhododendron anthopogonoide is cleaned, dry, shredded, soak in methyl alcohol 20 days, stir once within every 1 day, then filter, Decompression, boils off solvent, pinches molten in the hot water, is extracted respectively with ether three times, combining extraction liquid, concentration, dewaxing, is extracted Oil；
（3）Immersion：Chinese medicine composition is gone into the removal of impurity, cleaned up, dried, steeped into step（1）Miscella in, sealing leaching Bubble 15 days, is filtrated to get Chinese medicine material and medicine oil；
（4）Steam oil：Take out step（3）The Chinese medicine material of immersion, is put into jacketed pan and steams fuel-displaced, obtains steam oil；
（5）Heating：Western medicine compound, suspension stabilizer are added with the water of aliquot, water is heated to 70 DEG C, obtains liquid；
（6）Homogeneous：By step（5）Liquid be added in vacuum homogeneous emulsifying machine with assistant for emulsifying agent, moisturizing grease and mix, at a high speed Homogeneous, obtains homogeneous oil；
（7）Remix homogeneous：By step（3）Medicine oil, step（2）Extract oil, step（4）Steam oil, step（6）Homogeneous Oil mixes with essential oil, preservative, pours into vacuum viscolizer, high speed homogenization, obtains finished product medicine oil；
（8）Packaging：Sub-bottle packaging, sealing, sterilization.
A kind of Chinese and Western of alleviation periostitis symptom of above example combines medicine oil, is formed with Multiple components configuration, passes through External application smear site of disease be equipped with massage, can be effectively promoted blood circulation, soften connective tissue, elimination oedema, degerming throe, The effects such as recovering function of joint, and may also operate as avoiding more infectious-related complication, the effect of reduction amyotrophia.
The case with periostitis is tested using medicine oil of the invention：
1st, case selection：Patient 21 of the selection with periostitis, the age, at 16-58 Sui, falls ill most short 10 days, most long 1 year；
2nd, diagnostic criteria：Periostitis local pain, contrafluxion oedema, moving obstacle；
3rd, treatment method：Medicine oil of the invention is applied to affected part and is massaged 5-10 minutes, early daily, evening is each once, is within one week One course for the treatment of；
4th, therapeutic effect is judged：Healing-A, effect is significant-B, hence it is evident that improvement-C, unchanged-D
5th, result of the test：
Can be seen that total Test patient by above result of the test can all work after using medicine oil of the invention, most short A course for the treatment of can just cure, most long also has clear improvement by five courses for the treatment of, and to cure patient's later stage see Middle discovery is examined, the case not recurred again, therefore medicine oil of the invention has functions that good healing periostitis.

Claims (6)

1. a kind of Chinese and Western for alleviating periostitis symptom combines medicine oil, it is characterised in that by following raw materials system Into：Chinese medicine composition 58-140 parts, Western medicine compound 22-70 parts, rhododendron anthopogonoide 8-14 parts, methyl alcohol 42-60 parts, ether 33-42 Part, peppermint oil 80-120 parts, wintergreen 280-500 parts, Seabuckthorn Oil 30-55 parts, volatile oil extracted from eucalyptus' leaves or twigs 8-15 parts, essential oil 15-32 parts, help emulsification Agent 2-8 parts, suspension stabilizer 0.8-1.5 parts, 45-80 parts, preservative 0.08-0.4 parts of moisturizing grease.
2. a kind of Chinese and Western for alleviating periostitis symptom combines medicine oil according to claim 1, it is characterised in that the Chinese medicine group Compound is by Chinese juniper 3-6 parts, Sievers wormwood 2-6 parts, monkshood 4-8 parts, German tamarisk 2-5 parts, lamiophlomis rotata 5-9 parts, root of bidentate achyranthes 3-6 parts, drop It is fragrant 4-8 parts, santal 4-8 parts, frankincense 4-8 parts, dragon's blood 3-9 parts, sunset abelmoschus seed 2-5 parts, hooker winghead root 3-9 parts, root bark of Chinese wolf-berry 3-9 parts, Bark of ash 1-5 parts, west safflower 5-12 parts, rhizoma imperatae 3-8 parts, butterflybush flower 1-4 parts, borneol 5-10 parts mixes.
3. a kind of Chinese and Western for alleviating periostitis symptom combines medicine oil according to claim 1, it is characterised in that the Western medicine group Compound is mixed by paracetamol 5-20 parts, Ciprofloxacin Lactate 7-22 parts, C14H10Cl2NNaO2 10-28 parts.
4. a kind of Chinese and Western for alleviating periostitis symptom combines medicine oil according to claim 1, it is characterised in that the essential oil is Mixed by one or more in Essential Oil From Pine Needles, cinnamon essential oil, Bergamot, elemi quintessence oil, assistant for emulsifying agent is sweet Oil, suspension stabilizer is carbomer, and moisturizing grease is in dimethicone, isopropyl palmitate, isopropyl myristate One or more are mixed, and preservative is by one or more mixing in propylben, nipagin esters, phenoxetol Form.
5. a kind of Chinese and Western for alleviating periostitis symptom combines medicine oil according to claim 1, it is characterised in that by following by weight The raw material of amount part proportioning is made：98 parts of Chinese medicine composition, 56 parts of Western medicine compound, 11 parts of rhododendron anthopogonoide, 52 parts of methyl alcohol, ether 38 It is part, 100 parts of peppermint oil, 380 parts of wintergreen, 42 parts of Seabuckthorn Oil, 11 parts of volatile oil extracted from eucalyptus' leaves or twigs, 23 parts of essential oil, 6 parts of assistant for emulsifying agent, suspending stabilized 1.2 parts of agent, 62 parts of moisturizing grease, 0.22 part of preservative.
6. a kind of Chinese and Western for alleviating periostitis symptom combines the preparation method of medicine oil described in claim 1-5, it is characterised in that bag Include following steps：
（1）Mixing：Peppermint oil, wintergreen, Seabuckthorn Oil, volatile oil extracted from eucalyptus' leaves or twigs are mixed in proportion, miscella is obtained；
（2）Extract：Rhododendron anthopogonoide is cleaned, dry, shredded, soak 18-23 days in methyl alcohol, stirred once per 1-2 days, then Filtering, decompression, boil off solvent, pinch molten in the hot water, are extracted respectively with ether three times, combining extraction liquid, concentration, dewaxing, obtain Extract oil；
（3）Immersion：Chinese medicine composition is gone into the removal of impurity, cleaned up, dried, steeped into step（1）Miscella in, sealing leaching Bubble 10-20 days, is filtrated to get Chinese medicine material and medicine oil；
（4）Steam oil：Take out step（3）The Chinese medicine material of immersion, is put into jacketed pan and steams fuel-displaced, obtains steam oil；
（5）Heating：Western medicine compound, suspension stabilizer are added with the water of aliquot, water is heated to 68-75 DEG C, obtains liquid；
（6）Homogeneous：By step（5）Liquid be added in vacuum homogeneous emulsifying machine with assistant for emulsifying agent, moisturizing grease and mix, at a high speed Homogeneous, obtains homogeneous oil；
（7）Remix homogeneous：By step（3）Medicine oil, step（2）Extract oil, step（4）Steam oil, step（6）Homogeneous Oil mixes with essential oil, preservative, pours into vacuum viscolizer, high speed homogenization, obtains finished product medicine oil；
（8）Packaging：Sub-bottle packaging, sealing, sterilization.
CN201710162389.3A 2017-03-18 2017-03-18 A kind of Chinese and Western for alleviating periostitis symptom combines medicine oil and preparation method thereof Pending CN106806713A (en)

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