CN104548100A - External composition for treating skin diseases - Google Patents
External composition for treating skin diseases Download PDFInfo
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- CN104548100A CN104548100A CN201510017116.0A CN201510017116A CN104548100A CN 104548100 A CN104548100 A CN 104548100A CN 201510017116 A CN201510017116 A CN 201510017116A CN 104548100 A CN104548100 A CN 104548100A
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Abstract
The invention discloses an external composition for treating skin diseases. The external composition consists of effective components and pharmaceutically acceptable auxiliary materials. The external composition is characterized in that the effective components of the composition comprise povidone iodine, imidazole and/or triazole antifungal medicines and a skin penetrating agent, wherein a mass ratio of the available iodine content of povidone iodine to the imidazole and/or triazole antifungal medicines to the skin penetrating agent is (3-200):(2-400):(10-1600), and the skin diseases are caused by fungal infection and/or bacterial infection.
Description
Technical field
The present invention relates to one and treat dermopathic medicine, particularly a kind of dermopathic compositions of external curing containing povidone iodine.
Background technology
At present, the mycosis that the mankind can suffer from can be divided into following four classes substantially: studies of invasive fungal infections and systemic mycosis (as aspergillosis and candidiasis etc.), mucosal pattern mycosis (as " thrush " etc.), shallow phenotype dermatomycosis (as " tinea pedis ", " tinea unguium ", all kinds of " tineas " etc.) and anaphylactic type mycosis (as asthma and chronic inflammatory disease etc.).The harm of first kind mycosis is large, needs antifungal drug Comprehensive Treatment for oral administration, and mucosa type mycosis and shallow phenotype dermatomycosis are except interior application treatment, and more convenient and simple and direct is adopt external medication.Many dermatosis, often antibacterial and the compound infection of fungus, or fungal infection is formerly, causes the wound supervention bacteriological infection after cuticular breakdown.Therefore the outer of single antifungal effective ingredient is only had to have ointment, spray, liniment, daubing medicament can not treat the dermatosis that there is antibacterial and fungus MOI fast, in time.
Summary of the invention
For above-mentioned the deficiencies in the prior art, the invention provides the dermopathic compositions of a kind of external curing, effectively can treat the dermatosis of various tinea disease and fungus antibacterial MOI.
The dermopathic compositions of a kind of external curing provided by the invention, be made up of effective ingredient and pharmaceutically acceptable adjuvant, it is characterized in that, the effective ingredient of compositions comprises povidone iodine, imidazoles and/or antifungal drug in triazole class and skin penetrant, and the mass ratio of the available iodine content in described povidone iodine and imidazoles and/or antifungal drug in triazole class and skin penetrant is (3 ~ 200): (2 ~ 400): (10 ~ 1600); Described dermatosis is the dermatosis that fungus and/or bacteriological infection cause.
Preferably, described povidone iodine calculates with available iodine content, accounts for 0.03 ~ 2% of composition total weight.
Preferably, described imidazoles antifungal drug is the mixture of one or more in clotrimazole, miconazole, econazole, ketoconazole, tioconazole, butoconazole, sulconazole, oxiconazole and bifonazole; Antifungal drug in triazole class is one or more mixture in fluconazol, itraconazole and terconazole (triaconazole); The weight of imidazoles and/or antifungal drug in triazole class accounts for 0.02 ~ 4% of composition total weight.
Preferably, the antifungal drug in described effective ingredient is the one in following mixture:
The mixture of miconazole nitrate and itraconazole, both mass ratioes are 1:1;
The mixture of voriconazole and econazole, both mass ratioes are 1:1;
The mixture of voriconazole and miconazole nitrate, both mass ratioes are 1:1.
Preferably, described skin penetrant is one or more mixture in following component: have the azone class of saturated alkane base, pyrrolones, fitter acids and its ester class, alcohols and polyalcohols, sulfoxide type, amine and amide-type, terpenoid.
Preferably, described skin penetrant is laurocapram, accounts for composition total weight 0.1% ~ 3.0%.
Preferably, described skin penetrant is methyl laurate, accounts for composition total weight 1% ~ 8%.
Preferably, described skin penetrant is the one in following mixture:
The mixture of laurocapram and menthol, laurocapram weight accounts for 0.1% ~ 3.0% of composition total weight, and menthol weight accounts for 1% ~ 5% of composition total weight;
Laurocapram and lauric mixture, laurocapram weight accounts for 0.1% ~ 3.0% of composition total weight, and lauric acid weight accounts for 1% ~ 8% of composition total weight;
The mixture of lauric acid and methyl laurate, both respectively account for composition total weight 1% ~ 8%.
Preferably, containing the iodine stabilizing agent accounting for composition total weight 0.02 ~ 1.0% in the adjuvant of compositions, for the available iodine concentration stabilize of povidone iodine in control composition, described iodine stabilizing agent is potassium iodate and/or potassium iodate and potassium iodide compositions, and preferred consumption is 0.05 ~ 0.5%.
In the dermopathic compositions of a kind of external curing of the present invention, can select and include but not limited to that sodium dihydrogen phosphate and sodium hydrogen phosphate buffer system regulate the pH value of composite preparation within the scope of 5.0-8.0, preferably at 6.0-7.0.
The known suitable medical processing aid (including but not limited to surfactant, thickening agent, excipient, dispersant, foaming agent etc.) of pharmaceutical industry and processing method can be selected in above-mentioned composition, be processed into facilitate patient to use be including but not limited to the dosage forms such as ointment, spray, aqueous pharmaceutical, liniment, powder, suppository; Or be combined with dressing carrier and make application, plaster etc.
Compositions of the present invention can be used for external curing beriberi (tinea pedis, tinea pedis), the pharmaceutically acceptable adjuvant contained in compositions can make compositions be prepared into suitable preparation (water preparation, ointment, liniment, spray, ointment agent, dressing containing medicament), by known various mode, composite preparation is directly applied to the sufferer place of beriberi.
The all right various dermatophytosis of external curing (such as tinea capitis, tinea corporis, tinea cruris, the tinea manuum, tinea unguium, tinea versicolor, Tinea and microbid) of compositions of the present invention, by the preparation (water preparation, ointment, liniment, spray) that pharmaceutically acceptable adjuvant can be suitable, be directly applied to the sufferer place of all kinds of tinea by known various mode.
Compositions of the present invention can also be used for various furuncle, skin ulcer, furuncle, all kinds of dermatosis such as swollen caused because of bacteriological infection of external curing, the preparation (water preparation, ointment, liniment, spray, ointment agent, dressing containing medicament) of appropriately combined thing can be selected, be directly applied to the sufferer place of skin by known various mode.
Compositions of the present invention can also be used for external curing because of fungus (such as monilial infection) infect and or gynecological's vulvitis of bacteriological infection and vaginitis disease, suitable preparation (water preparation, ointment, suppository, irrigation etc.) can be selected, be directly applied to sufferer place by known various mode or put into intravaginal with suppository.
The dermopathic compositions of a kind of external curing provided by the invention, has following beneficial effect:
(1) povidone iodine is used in formula as the dermopathic active drug component for the treatment of, synergism is played with antifungal drug imidazoles and triazole type medicine compatibility, suffer from local for dermatosis outward, treat all kinds of dermatophytosis and furuncle furuncle and phyma bacteriological infection dermatoses.
(2) in recipe ingredient, the reasonable combination of imidazoles and antifungal drug in triazole class is arranged in pairs or groups, be used for the treatment of the dermatosis of mucosal pattern and the infection of shallow phenotype fungus and bacterium, avoid oral administration or injection to use imidazoles and antifungal drug in triazole class to the toxic and side effects of health.
(3) each component in skin penetrant can play collaborative osmosis, strengthens drug effect, can reach the target of the use amount reducing drug component simultaneously by the transdermal penetration effect improving drug component.
(4) effectively can treat fungus and bacterium and infect the composite skin disease caused, and instant effect, can not recur after healing.
Detailed description of the invention
In order to make those skilled in the art person understand technical scheme of the present invention better, below in conjunction with detailed description of the invention, the present invention is described in further detail.
Embodiment 1
External curing is dermopathic containing povidone iodine compositions, and formula is benchmark according to the ointment of total amount 1000g, and wherein the consumption proportion of various component is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Itraconazole (Itraconazole) 15g
Miconazole nitrate (Miconazole Nitrate) 15g
Laurocapram (Laurocapram) 20g
Potassium iodate 2g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=6-7)
Purified water 440g
Processing aid (glyceryl monostearate 15g, stearic acid 10g, triethanolamine 10g, glycerol 5g, ethyl hydroxybenzoate 3g, white vaseline 60, liquid Paraffin 350, double stearic acid aluminium 5g)
Formula total amount adds up to 1000g
In 3000ml beaker, drop into processing aid and itraconazole (Itraconazole) miconazole nitrate (Miconazole Nitrate) laurocapram (Laurocapram) potassium iodate of above-mentioned formula ratio, be heated to 80-85 DEG C of fusing, stir;
In another 1000ml beaker, add 440ml pure water and 50g povidone iodine, stirring and dissolving obtains dark-brown betagen solution completely;
By the betagen solution dissolved, under agitation slowly pouring into has dissolved in the beaker of processing aid, be uniformly mixed, mix homogeneously is beaten with miniature high-speed shearing emulsifier, according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=6-7, make oiliness external curing dermopathic containing povidone iodine compositions.Said composition is particularly suitable for treatment squama keratinization type tinea pedis (beriberi), is directly applied in affected part during use.
Embodiment 2:
External curing is dermopathic containing povidone iodine compositions, and formula is benchmark according to total amount 1000g ointment, and various amounts of components proportioning is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Voriconazole (Voriconazole) 15g
Econazole (Econazole) 15g
Laurocapram (Laurocapram) 20g
Propylene glycol 10g
Potassium iodate 2g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=6-7)
Purified water 638g
Processing aid (sodium carboxymethyl cellulose (CMC) 50g, Polyethylene Glycol (2000) 100g, glycerol 100g)
Formula total amount adds up to: 1000g
In 3000ml beaker, put into auxiliary agent Polyethylene Glycol, voriconazole, econazole, laurocapram, propylene glycol and potassium iodate, be heated to Polyethylene Glycol fusing, mixture stirs.
In mortar, povidone iodine powder 50g and sodium carboxymethyl cellulose 50g mixed and add glycerol 100g, grind in mortar and be mixed even, progressively add purified water and after grinding mixed general uniform, cover lid, allow povidone iodine and carboxymethyl cellulose water suction fully swelling, and then grind be mixed even for paste.
By the mixing of two pre-formed component, grind and be mixed even, according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=6-7, make water solublity external curing dermopathic containing povidone iodine compositions unguentum.Said composition is applicable to treatment and festers type and blister type tinea pedis (beriberi), and the dermatosis such as the skin furuncle furuncle and phyma that causes of bacteriological infection, is directly applied in affected part during use.
Embodiment 3:
External curing is dermopathic containing povidone iodine compositions, and formula is benchmark according to total amount 1000g thickening type water preparation, and the consumption proportion of various component is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Voriconazole (Voriconazole) 15g
Miconazole nitrate (Miconazole Nitrate) 15g
Laurocapram (Laurocapram) 20g
Menthol 10g
Potassium iodate 2g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=6-7)
Purified water 768g
Processing aid (sodium lauryl sulphate 5g, glyceryl monostearate, 5g, sodium carboxymethyl cellulose (CMC) 10g, glycerol 100g)
In 3000ml beaker, add povidone iodine, potassium iodate, sodium lauryl sulphate, glyceryl monostearate and sodium carboxymethyl cellulose, add purified water, stir lower dissolving completely;
Glycerol and voriconazole, miconazole nitrate, laurocapram and menthol is put in mortar, grind be mixed even after add in prefabricated aqueous phase, stirring and emulsifying evenly (using small-sized high-shear emulsifying agent to prepare more convenient and quicker), according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=6-7, prepare external curing dermopathic containing povidone iodine compositions viscous water dosage formulation.May be used for all kinds of dermatophytosis and furuncle furuncle and phyma treating for skin disease.Medicament can be dipped with cotton swab, directly be applied in affected part, or with the upper medicament of gauze leaching, cover or be wrapped in skin affected part.
Embodiment 4:
External curing is dermopathic containing povidone iodine compositions, and formula is benchmark according to total amount 1000g water preparation, and the proportioning of various component is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Miconazole nitrate (Miconazole Nitrate) 20g
Laurocapram (Laurocapram) 20g
Propylene glycol 10g
Potassium iodate 1g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=5-6)
Purified water 790g
Processing aid (sodium lauryl sulphate 5g, glyceryl monostearate, 4g, glycerol 100g)
In 3000ml beaker, add povidone iodine, potassium iodate, sodium lauryl sulphate, glyceryl monostearate, add purified water, stir lower dissolving completely;
Glycerol and miconazole nitrate, laurocapram and propylene glycol is put in mortar, grind be mixed even after add in prefabricated aqueous phase, stirring and emulsifying evenly (using small-sized high-shear emulsifying agent to prepare more convenient and quicker), according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=5-6, prepare external curing dermopathic containing povidone iodine compositions water aqua type preparation.May be used for all kinds of dermatophytosis and furuncle furuncle and phyma treating for skin disease.Medicament can be dipped with cotton swab, directly be applied in affected part, or with the upper medicament of gauze leaching, cover or be wrapped in skin affected part.
Embodiment 5:
External curing is dermopathic containing povidone iodine compositions, and formula is example according to total amount 1000g ointment, and the consumption proportion of various component is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Itraconazole (Itraconazole) 15g
Laurocapram (Laurocapram) 20g
Stearic acid 10g
Potassium iodate 2g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=6-7)
Purified water 455g
Processing aid (glyceryl monostearate 15g, triethanolamine 10g, glycerol 5g, ethyl hydroxybenzoate 3g, white vaseline 60, liquid Paraffin 350, double stearic acid aluminium 5g)
Formula total amount adds up to 1000g
In 3000ml beaker, drop into processing aid and itraconazole (Itraconazole) laurocapram (Laurocapram) stearic acid of above-mentioned formula ratio, be heated to 80-85 DEG C of fusing, stir;
In another 1000ml beaker, add 455ml pure water and 50g povidone iodine and potassium iodate, stirring and dissolving obtains dark-brown betagen solution completely;
By the betagen solution dissolved, under agitation slowly pouring into has dissolved in the beaker of processing aid, be uniformly mixed, mix homogeneously is beaten with miniature high-speed shearing emulsifier, according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=6-7, make oiliness external curing dermopathic containing povidone iodine compositions.Said composition is suitable for treating non-ulcer type dermatophytosis, is directly applied in affected part during use.
Embodiment 6
External curing is dermopathic containing povidone iodine compositions, and formula is example according to total amount 1000g ointment, and the consumption proportion of various component is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Itraconazole (Itraconazole) 15g
Laurocapram (Laurocapram) 20g
Lauric acid 20g
Potassium iodate 2g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=6-7)
Purified water 445g
Processing aid (glyceryl monostearate 15g, triethanolamine 10g, glycerol 5g, ethyl hydroxybenzoate 3g, white vaseline 60, liquid Paraffin 350, double stearic acid aluminium 5g)
Formula total amount adds up to 1000g
In 3000ml beaker, drop into processing aid and itraconazole (Itraconazole) laurocapram (Laurocapram) lauric acid of above-mentioned formula ratio, be heated to 80-85 DEG C of fusing, stir;
In another 1000ml beaker, add 445ml pure water and 50g povidone iodine and potassium iodate, stirring and dissolving obtains dark-brown betagen solution completely;
By the betagen solution dissolved, under agitation slowly pouring into has dissolved in the beaker of processing aid, be uniformly mixed, mix homogeneously is beaten with miniature high-speed shearing emulsifier, according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=6-7, make oiliness external curing dermopathic containing povidone iodine compositions.Said composition is suitable for treating non-ulcer type dermatophytosis, is directly applied in affected part during use.
Embodiment 7
External curing is dermopathic containing povidone iodine compositions, and formula is example according to total amount 1000g ointment, and the consumption proportion of various component is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Itraconazole (Itraconazole) 15g
Methyl laurate 30g
Potassium iodate 2g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=6-7)
Purified water 455g
Processing aid (glyceryl monostearate 15g, triethanolamine 10g, glycerol 5g, ethyl hydroxybenzoate 3g, white vaseline 60, liquid Paraffin 350, double stearic acid aluminium 5g)
Formula total amount adds up to 1000g
In 3000ml beaker, drop into processing aid and itraconazole (Itraconazole) methyl laurate of above-mentioned formula ratio, be heated to 80-85 DEG C of fusing, stir;
In another 1000ml beaker, add 455ml pure water and 50g povidone iodine and potassium iodate, stirring and dissolving obtains dark-brown betagen solution completely;
By the betagen solution dissolved, under agitation slowly pouring into has dissolved in the beaker of processing aid, be uniformly mixed, mix homogeneously is beaten with miniature high-speed shearing emulsifier, according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=6-7, make oiliness external curing dermopathic containing povidone iodine compositions.Said composition is suitable for treating non-ulcer type dermatophytosis, is directly applied in affected part during use.
Embodiment 8
External curing is dermopathic containing povidone iodine compositions, and formula is example according to total amount 1000g ointment, and the consumption proportion of various component is as follows:
Povidone iodine powder (containing available iodine 10%) 50g
Itraconazole (Itraconazole) 15g
Methyl laurate 30g
Lauric acid 20g
Potassium iodate 2g
PH buffer agent (sodium dihydrogen phosphate/sodium hydrogen phosphate) appropriate (regulating pH=6-7)
Purified water 435g
Processing aid (glyceryl monostearate 15g, triethanolamine 10g, glycerol 5g, ethyl hydroxybenzoate 3g, white vaseline 60, liquid Paraffin 350, double stearic acid aluminium 5g)
Formula total amount adds up to 1000g
In 3000ml beaker, drop into the processing aid of above-mentioned formula ratio and itraconazole (Itraconazole) methyl laurate and lauric acid, be heated to 80-85 DEG C of fusing, stir;
In another 1000ml beaker, add 435ml pure water and 50g povidone iodine and potassium iodate, stirring and dissolving obtains dark-brown betagen solution completely;
By the betagen solution dissolved, under agitation slowly pouring into has dissolved in the beaker of processing aid, be uniformly mixed, mix homogeneously is beaten with miniature high-speed shearing emulsifier, according to pharmaceutical industry known method sodium dihydrogen phosphate/sodium hydrogen phosphate buffer system regulation system pH=6-7, make oiliness external curing dermopathic containing povidone iodine compositions.Said composition is suitable for treating non-ulcer type dermatophytosis, is directly applied in affected part during use.
Case 1
Xu certain, 31 years old, male, suffered from squama keratinization type tinea pedis (beriberi) 6 years, used the equal symptom of multiple antimycotic marketed drugs to make moderate progress, and recurred after drug withdrawal.The medicine that the embodiment of the present invention 1 provides is used in last medication instead after 30 days, apply affected part every day 2 times, each consumption 12-15g, remission in 24h, and after January, tinea pedis is removed completely, follows up a case by regular visits to and does not recur for 9 months.
Case 2
Normal certain, 19 years old, male, suffered from fester type and blister type tinea pedis from 16 years old, both alternately mix outbreak, long-term acceptance commercially available for oral administration/external medication do not have clear improvement, the medicine that the embodiment of the present invention 2 provides is used in last medication instead after 30 days, apply twice, affected part every day, each consumption 12-15g, remission in 48h, after 2 weeks, tinea pedis is removed completely, follows up a case by regular visits to after 11 months and does not recur.
Case 3
Zhang, 27 years old, women, suffers from tinea versicolor 3 years, long-term accept commercially available for oral administration/external medication do not have clear improvement, the medicine that the embodiment of the present invention 3 provides is used in last medication instead after 30 days, apply affected part twice every day, each consumption 12-15g, remission in 48h, after 2 weeks, tinea versicolor removes recovery from illness completely, follows up a case by regular visits to after 11 months and does not recur.
Case 4
Ke, 52 years old, male, abdominal part and lower limb suffer from erythra 4 years, it is invalid that layer accepts multiple external medication, and the medicine using the embodiment of the present invention 6 to provide, applies affected part every day 3 times, each consumption 12-15g, remission in 24h, after 12 days, erythra is removed completely, follows up a case by regular visits to after 8 months and does not recur.
Test example 1
Zoopery:
Choose kunming mice 90, male and female are random, be divided into 9 groups, back unhairing, with No. 200 sand paper scratch marks, Simultaneous vaccination alpha fungus and staphylococcus aureus, set up mice fungus, antibacterial MOI model, 1 ~ 8 group applies the medicine using embodiment 1 ~ 8 to provide respectively, and the 9th group as blank group.Administration 3 ~ 7 days, observes mice skin lesion and improves and fungus and bacterium removing situation.Outcome record in table 1 below
Table 1 results of animal
As seen from the above table, compositions medicament provided by the invention can the dermatosis that causes of fast treating fungus and bacterium MOI, medication effect in embodiment 3 is the most remarkable, just almost fungus and bacterium all can be removed completely, take effect and be exceedingly fast after medication 72h.
Above the dermopathic compositions of a kind of external curing provided by the present invention is described in detail.Apply specific case herein to set forth principle of the present invention and embodiment, the explanation of above embodiment just understands core concept of the present invention for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, some improvement and modification can also be carried out to the present invention.These improve and modify and also should fall in the protection domain of the claims in the present invention.
Claims (9)
1. the dermopathic compositions of external curing, be made up of effective ingredient and pharmaceutically acceptable adjuvant, it is characterized in that, the effective ingredient of compositions comprises povidone iodine, imidazoles and/or antifungal drug in triazole class and skin penetrant, and the mass ratio of the available iodine content in described povidone iodine and imidazoles and/or antifungal drug in triazole class and skin penetrant is (3 ~ 200): (2 ~ 400): (10 ~ 1600); Described dermatosis is the dermatosis that fungus and/or bacteriological infection cause.
2. the dermopathic compositions of external curing according to claim 1, is characterized in that, described povidone iodine calculates with available iodine content, accounts for 0.03 ~ 2% of composition total weight.
3. the dermopathic compositions of external curing according to claim 1, it is characterized in that, described imidazoles antifungal drug is the mixture of one or more in clotrimazole, miconazole, econazole, ketoconazole, tioconazole, butoconazole, sulconazole, oxiconazole and bifonazole; Antifungal drug in triazole class is one or more mixture in fluconazol, itraconazole and terconazole (triaconazole); The weight of imidazoles and/or antifungal drug in triazole class accounts for 0.02 ~ 4% of composition total weight.
4. the dermopathic compositions of external curing according to claim 3, is characterized in that, the antifungal drug in described effective ingredient is the one in following mixture:
The mixture of miconazole nitrate and itraconazole, both mass ratioes are 1:1;
The mixture of voriconazole and econazole, both mass ratioes are 1:1;
The mixture of voriconazole and miconazole nitrate, both mass ratioes are 1:1.
5. the dermopathic compositions of external curing according to claim 1, it is characterized in that, described skin penetrant is one or more mixture in following component: have the azone class of saturated alkane base, pyrrolones, fitter acids and its ester class, alcohols and polyalcohols, sulfoxide type, amine and amide-type, terpenoid.
6. the dermopathic compositions of external curing according to claim 5, is characterized in that, described skin penetrant is laurocapram, accounts for composition total weight 0.1% ~ 3.0%.
7. the dermopathic compositions of external curing according to claim 5, is characterized in that, described skin penetrant is methyl laurate, accounts for composition total weight 1% ~ 8%.
8. the dermopathic compositions of external curing according to claim 5, is characterized in that, described skin penetrant is the one in following mixture:
The mixture of laurocapram and menthol, laurocapram weight accounts for 0.1% ~ 3.0% of composition total weight, and menthol weight accounts for 1% ~ 5% of composition total weight;
Laurocapram and lauric mixture, laurocapram weight accounts for 0.1% ~ 3.0% of composition total weight, and lauric acid weight accounts for 1% ~ 8% of composition total weight;
The mixture of lauric acid and methyl laurate, both respectively account for composition total weight 1% ~ 8%.
9. the dermopathic compositions of external curing according to claim 1, is characterized in that, containing the iodine stabilizing agent accounting for composition total weight 0.05 ~ 0.5% in the adjuvant of compositions, described iodine stabilizing agent is the compositions of potassium iodate and/or potassium iodate and potassium iodide.
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| WO2017216722A3 (en) * | 2016-06-13 | 2018-03-01 | Vyome Biosciences Pvt. Ltd. | Synergistic antifungal compositions and methods thereof |
| CN109689034A (en) * | 2016-06-13 | 2019-04-26 | 维奥梅治疗有限公司 | Cooperate with antifungal composition and its method |
| CN113456769A (en) * | 2021-07-27 | 2021-10-01 | 西安浦源生物科技有限公司 | A topical Chinese medicinal composition for treating dermatoses, and its preparation method |
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