CN1596908A - Sterilization bacteria inhibition compound iodophor medicine and its preparation and preparation technology - Google Patents
Sterilization bacteria inhibition compound iodophor medicine and its preparation and preparation technology Download PDFInfo
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Abstract
A compound tamed iodine for killing the bacteria on skin and mucosa by exterior applying is prepared from tamed iodine, and the composition of terbinafine hydrochloride and/or bunafine hydrochloride and/or fluconazole, etc.
Description
Technical field
The present invention relates to a kind of sterilization, antibacterial medicines compositions, relate in particular to a kind of bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine and preparation and preparation technology.
Background technology
Povidone iodine (Iodophor) is iodine and surfactant, as the indefinite form conjugate of materials such as polyvinylpyrrolidone, polyoxyethylene ether, i.e. and polyvinylpyrrolidone-iodine (PVP-I), Nonyl pheno dodecane alcohol ether-iodine (NP
10-I), NPE-iodine (POP-I), PEG-I (PEG-I), alkylsulfonate-iodine (ASE-I), poly-third oxygen ether-iodine (PPE-I), alkane alkene imidazoles-iodine (PVI-I), polyvinyl alcohol-iodine (APA-I), ring glucoside-iodine povidone iodine such as (CD-I).In medical povidone iodine, (PVP-I) is the most frequently used for polyvinylpyrrolidone-iodine.Povidone iodine is to gram positive bacteria and negative bacterium sensitivity, effective to acid-fast bacilli, bacterial spore, fungus, lipophilic virus and hydrophilic viruses, but bactericidal action is slow, after 2--3 minute, just can better bring into play bactericidal action, shorter at skin and mucosa reservation effective time, the low concentration bacteriostasis is also relatively poor.Terbinafine HCl (is called for short terbinafine, Terbinafine), naftifine hydrochloride (is called for short naftifine, Naftifine), Butenafine Hydrochloride (is called for short fourth naphthalene sweet smell, Butenafine), fluconazol (Fluconazole), ciclopirox olamine (CiclopiroxOlamine) are antifungal drug, it is characterized in that the higher mycostasis that kills is arranged, cure rate is higher and relapse rate is lower in a short time, but patient to some dermatomycosis or fungus, the two mixed infection of antibacterial, curative effect is not ideal enough, to antibacterial unrestraint and killing action.Existing market demand has the medicine and the disinfecting drug of better therapeutic effect to skin and mucosa antibacterial, fungal infection or fungus, the two mixed infection of antibacterial.
Summary of the invention
The purpose of this invention is to provide a kind of sterilization, antibacterial medicines compositions, a kind of bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine and preparation and preparation technology especially are provided, overcome above-mentioned one-component can not more effective bacteriostasis and sterilization and the disease that causes of treatment skin bacterium or fungal infection or antibacterial and the two mixed infection of fungus and external can not be rapider and the long period continue the shortcoming of sterilization.
The present invention is achieved through the following technical solutions:
A kind of germ killing drugs compositions comprises the pharmaceutical composition of povidone iodine and terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine;
A kind of germ killing drugs compositions, be that povidone iodine: terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine are 0.05～2.0: 0.1～5.0 by the medicament (the povidone iodine weight portion refers to available iodine content) that comprises that following weight parts proportioning ratio component is made; Be preferably 0.2～1.0: 0.5～2.0; Especially it is 0.5: 1.0.
Described medicament can be said skin on any pharmaceutics and mucosa delivery dosage form; Especially can be solution, tincture, lotion, spray, liniment, ointment, ointment, membrane, varnish, suppository, gel;
Described medicament can also be said disinfectant on any pharmaceutics; Especially can be liquid disinfectant, sterilized cotton ball (cotton swab), granule, ointment, gel, disinfectant tablet, membrane, effervescent and disinfectant powder.
The preparation method of described antibacterial combination may further comprise the steps:
Take by weighing povidone iodine, terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine in described ratio, the preparation method of complying with conventional dermatologic and disinfectant is prepared from;
Described sterilization, antibacterial medicines compositions also can comprise available adjuvant on the materia medica;
The present invention has following effect and advantage:
1) medicine of the present invention has collaborative and potentiation to microorganisms such as antibacterium, funguses.Utilize two kinds of drug component effects separately, make up the back and find that composition medicine has snap action aspect killing microorganisms and the long period continues antibacterial, bactericidal action, and kept that two kinds of medicines property of medicine in the compound medicines preparation is stable, the characteristics of effect stability.
2) can be used for developing new compound external-use local application and disinfectant, as compositions ointment, solution and disinfectant etc., the patient who clinically some cutaneous fungal infection is merged bacterial infection, unique curative effect and disinfective action are arranged, also do not influence simple fungus or bacterial infection treating for skin disease effect and remove pathogen.Clinical principium test above-mentioned composition ointment and solution, treatment numerical example dermatophytes or antibacterial, or fungus and antibacterial the two infect the patient of mixed infection, and disinfectant is used for sterilizations such as surgical patient, surgical operation, gynecological, the department of stomatology, all obtains satisfied curative effect and effect.
Described advantage of the present invention and effect can illustrate by following experiment.
One, to the bacteriostasis of several frequently seen malignant bacteria and fungus
1, materials and methods
Fungus is drawn from the air force general hospital department of dermatologry, and antibacterial is drawn from preventive medicine academy of science institute of Antibiotics and air force general hospital clinical laboratory.Used strain is staphylococcus aureus, escherichia coli, trichophyton and Candida albicans.
Fungi culture medium is the Sha Shi broth bouillon, and by mainly being made up of 1% peptone and 2% glucose, PH is 6-6.5; Bacteria culture media is an ordinary broth, and PH is 7.
Povidone iodine (PVP-I, down together) and terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or the different ratio preparation of ciclopirox olamine are pressed in the preparation of medicinal liquid culture medium.Each composite formula 5mg with 1ml 95% dissolve with ethanol, adds sterile distilled water to 5ml earlier again; Respectively draw above-mentioned dosing 0.2ml then, be added to respectively in the culture medium of 1.8ml, shake up the medicinal liquid culture medium that the back two-fold dilution goes out variable concentrations.During experiment, add bacterium liquid 0.02ml among every pipe medicinal liquid culture medium 1ml; It is individual that 1ml contains antibacterial or 105-107 of hair tinea or yeast-like fungi 104-105.After shaking up, antibacterial is put in the 35-37 ℃ of incubator and cultivated 24 hours, and fungus is put in the 28-32 ℃ of incubator and cultivated 48 hours, observed result.
The drug effect criterion, the limpid medicine blank pipe that is same as of meat soup is for there being bacteriostasis; Meat soup is obviously muddy, or the Mycoderma growth is arranged, and then is no bacteriostasis.
3, result
Bacteriostatic test shows, compositions compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen and its component povidone iodine, terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine are different to the minimal inhibitory concentration (MIC) of common malignant bacteria of 4 strains and fungus (representing bacterium), povidone iodine and terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine are in (0.02～2.0): (0.01～2.0) weight portion (povidone iodine weight refers to amount of iodine) proportioning ratio compositions formulated is lower to the minimal inhibitory concentration of several frequently seen pathomycete, effect is strong (seeing Table 1-5), behind proof povidone iodine and terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or the ciclopirox olamine compatibility, the effect of antibacterium and fungus is unaffected, especially aspect antifungal, compositions is better than its component drug, and two medicine compatibilities have synergism and potentiation are arranged.
Two, to the killing action of several frequently seen malignant bacteria, spore and fungus
1, materials and methods
The bactericidal assay method is the carrier quantitation method.Used strain is staphylococcus aureus, escherichia coli, bacillus subtilis black variety gemma and Candida albicans.Bacteria suspension is with containing 2% peptone water solution dilution.Select suitable nertralizer.Through evidence, can dispel medicine inhibitory action in compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen (PVP-I, down with) solution and its component medicine fully with dilution method.
Test is defat calico sheet (1.0 * 1.0cm with carrier
2).The microbiological contamination method is for dripping the method for dying.During test, the microbiological contamination print is put into the medicinal liquid that splendid attire is good in advance (each print consumption 5ml), and (20-25 ℃) acts on to official hour at normal temperatures, and aseptic method is taken out the test print, characteristics according to each magistral medicines, with diluted (dilution method) 10-100 doubly, reduce residual disinfectancy liquid concentration, eliminate the inhibitory action of disinfectant solution microorganism, resampling 0.5ml inoculates plate, 2 plates of each sample inoculation then with agar tilt-pour process counting survival clump count, and calculate bactericidal effect.
2, result
Prove through test of many times, compositions is compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (1), (2), (3), (4) and (5) prescription, escherichia coli, staphylococcus aureus and white beads are demonstrated killing effect preferably, and 1 minute killing rate of (20-25 ℃) effect can reach 96.88%-99.96% at normal temperatures; Act on 5 minutes, can reach 100% (seeing Table 6-10); But its component medicine terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine list component drugs are invalid substantially to the killing action of escherichia coli, staphylococcus aureus and Candida albicans, or very little.Especially to Candida albicans, compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (1-5) prescription, with the bactericidal action of its component medicine povidone iodine, terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine list component drugs, carry out statistics respectively relatively, all have significant difference (p＜0.01).
The external bacteriostasis of table 1 povidone iodine and terbinafine HCl variable concentrations compatibility to several frequently seen pathogenic microorganism
Minimal inhibitory concentration (MIC, μ g/ml)
Povidone iodine: terbinafine HCl
Staphylococcus aureus e coli trichophyton Candida albicans
0.05∶0.1 10.00 5.000 0.0032 1.250
0.3∶0.5 5.000 2.500 0.0016 1.250
0.3∶1.0 5.000 5.000 0.0008 0.625
0.3∶2.0 --- --- --- ---
0.3∶0.1 5.000 5.000 0.0032 1.250
0.5∶0.3 2.500 2.500 0.0016 1.250
0.5∶0.5 2.500 2.500 0.0008 1.250
0.5∶0.8 2.500 2.500 0.0008 1.250
0.5∶1.0 2.500 2.500 0.0004 0.625
0.5∶2.0 --- --- --- ---
1.0∶0.2 1.250 1.250 0.0032 2.500
1.0∶0.3 1.250 1.250 0.0032 1.250
1.0∶0.5 1.250 1.250 0.0016 1.250
1.0∶0.8 1.250 1.250 0.0008 0.625
2.0∶1.0 0.625 0.625 0.0016 0.625
2.5∶0.5 --- --- --- ---
1.0: 0.0 (single medicine contrast) 2.500 2.500 10.000 10.000
0.0: 1.0 (single medicine contrasts) 0.000 0.000 0.0032 2.500
Annotate: 1. the antibacterial bacterium was cultivated 24 hours, 48 hours observed results of fungal culture.
2. the high dissolving of "---" drug level is bad, can't observed result.
The external bacteriostasis of table 2 povidone iodine and naftifine hydrochloride variable concentrations compatibility to several frequently seen pathogenic microorganism
Minimal inhibitory concentration (MIC, μ g/ml)
Povidone iodine: naftifine hydrochloride
Staphylococcus aureus e coli trichophyton Candida albicans
0.05∶0.1 20.00 10.00 0.050 2.500
0.1∶0.2 10.00 5.000 0.025 2.500
0.3∶0.5 5.000 2.500 0.0125 1.250
0.3∶1.0 5.000 5.000 0.0062 0.625
0.3∶2.0 --- --- --- ---
0.3∶0.1 5.000 5.000 0.025 2.500
0.5∶0.3 2.500 2.500 0.025 1.250
0.5∶0.5 2.500 2.500 0.0125 1.250
0.5∶0.8 2.500 2.500 0.0125 1.250
0.5∶1.0 2.500 2.500 0.0062 0.625
0.5∶2.0 --- --- --- ---
1.0∶0.2 1.250 1.250 0.0125 1.250
1.0∶0.3 1.250 1.250 0.0125 1.250
1.0∶0.5 1.250 1.250 0.0062 1.250
1.0∶0.8 1.250 1.250 0.0062 0.625
2.0∶1.0 0.625 0.625 0.0032 0.312
2.5∶0.5 --- --- --- ---
1.0: 0.0 (single medicine contrast) 2.500 2.500 10.000 10.000
0.0: 1.0 (single medicine contrasts) 0.000 0.000 0.025 2.500
Annotate: 1. antibacterial culturing is 24 hours, 48 hours observed results of fungal culture.
2. the high dissolving of "---" drug level is bad, can't observed result.
The external bacteriostasis of table 3 povidone iodine and Butenafine Hydrochloride variable concentrations compatibility to several frequently seen pathogenic microorganism
Minimal inhibitory concentration (MIC, μ g/ml)
Povidone iodine: Butenafine Hydrochloride
Staphylococcus aureus e coli trichophyton Candida albicans
0.05∶0.1 10.00 10.00 0.025 1.250
0.1∶0.2 10.00 5.000 0.025 1.250
0.3∶0.5 5.000 2.500 0.0125 0.625
0.3∶1.0 5.000 5.000 0.0062 0.156
0.3∶2.0 --- --- --- ---
0.3∶0.1 5.000 5.000 0.025 1.250
0.5∶0.3 2.500 2.500 0.025 0.625
0.5∶0.5 2.500 2.500 0.0125 0.625
0.5∶0.8 2.500 2.500 0.0125 0.625
0.5∶1.0 2.500 2.500 0.0062 0.156
0.5∶2.0 --- --- --- ---
1.0∶0.2 1.250 1.250 0.0125 0.625
1.0∶0.3 1.250 1.250 0.0125 0.625
1.0∶0.5 1.250 1.250 0.0062 0.625
1.0∶0.8 1.250 1.250 0.0062 0.312
2.0∶1.0 0.625 0.625 0.0032 0.156
2.5∶0.5 --- --- --- ---
1.0: 0.0 (single medicine contrast) 2.500 2.500 10.000 10.000
0.0: 1.0 (single medicine contrasts) 0.000 0.000 0.025 0.625
Annotate: 1. antibacterial culturing is 24 hours, 48 hours observed results of fungal culture.
2. the high dissolving of "---" drug level is bad, can't observed result.
The external bacteriostasis of table 4 povidone iodine and fluconazol variable concentrations compatibility to several frequently seen pathogenic microorganism
Minimal inhibitory concentration (MIC, μ g/ml)
Povidone iodine: fluconazol
Staphylococcus aureus e coli trichophyton Candida albicans
0.05∶0.1 20.00 10.00 0.050 2.500
0.1∶0.2 10.00 5.000 0.025 2.500
0.3∶0.5 5.000 2.500 0.0125 0.625
0.3∶1.0 5.000 5.000 0.0062 0.312
0.3∶2.0 --- --- --- ---
0.3∶0.1 5.000 5.000 0.025 2.500
0.5∶0.3 2.500 2.500 0.025 1.250
0.5∶0.5 2.500 2.500 0.0125 1.250
0.5∶0.8 2.500 2.500 0.0125 1.250
0.5∶1.0 2.500 2.500 0.0062 0.312
0.5∶2.0 --- --- --- ---
1.0∶0.2 1.250 1.250 0.0125 1.250
1.0∶0.3 1.250 1.250 0.0125 1.250
1.0∶0.5 1.250 1.250 0.0062 0.625
1.0∶0.8 1.250 1.250 0.0062 0.312
2.0∶1.0 0.625 0.625 0.0032 0.312
2.5∶0.5 --- --- --- ---
1.0: 0.0 (single medicine contrast) 2.500 2.500 10.000 10.000
0.0: 1.0 (single medicine contrasts) 0.000 0.000 0.025 1.250
Annotate: 1. antibacterial culturing is 24 hours, 48 hours observed results of fungal culture.
2. the high dissolving of "---" drug level is bad, can't observed result.
The external bacteriostasis of table 5 povidone iodine and ciclopirox olamine variable concentrations compatibility to several frequently seen pathogenic microorganism
Minimal inhibitory concentration (MIC, μ g/ml)
Povidone iodine: ciclopirox olamine
Staphylococcus aureus e coli trichophyton Candida albicans
0.05∶0.1 10.00 5.000 0.250 2.500
0.1∶0.2 5.000 2.500 0.250 2.500
0.3∶0.5 2.500 2.500 0.125 0.625
0.3∶1.0 1.250 1.250 0.062 0.625
0.3∶2.0 --- --- --- ---
0.3∶0.1 5.000 5.000 0.250 2.500
0.5∶0.3 2.500 2.500 0.250 1.250
0.5∶0.5 2.500 2.500 0.125 1.250
0.5∶0.8 1.250 2.500 0.125 1.250
0.5∶1.0 1.250 1.250 0.062 0.625
0.5∶2.0 --- --- --- ---
1.0∶0.2 1.250 1.250 0.125 1.250
1.0∶0.3 1.250 1.250 0.125 1.250
1.0∶0.5 0.625 0.625 0.062 1.250
1.0∶0.8 0.625 0.625 0.062 0.625
2.0∶1.0 0.312 0.312 0.032 0.312
2.5∶0.5 --- --- --- ---
1.0: 0.0 (single medicine contrast) 2.500 2.500 10.000 10.000
0.0: 1.0 (single medicine contrasts) 2.500 2.500 0.250 1.250
Annotate: 1. antibacterial culturing is 24 hours, 48 hours observed results of fungal culture.
2. the high dissolving of "---" drug level is bad, can't observed result.
Table 6 compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (1) and component medicine thereof are to the killing effect of several microorganisms
The strain classification contrasts different (Min) killing rates action time (%) of average bacterium number
(cfu/ sheet) 135 10
Compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (1):
Staphylococcus aureus 1,119,000 99.96 99.99 100.00 100.00
Escherichia coli 1,060,000 96.56 99.99 100.00 100.00
Spores of bacillus subtilin 1,067,000 70.76 95.66 99.99 100.00
Candida albicans 128,000 96.88 99.99 100.00 100.00
Iodophor solution:
Staphylococcus aureus 1,119,000 99.56 99.85 99.99 100.00
Escherichia coli 1,060,000 92.81 99.97 99.99 100.00
Spores of bacillus subtilin 1,067,000 65.52 93.67 99.68 100.00
Candida albicans 128,000 76.57 99.62 99.92 100.00
Terbinafine HCl solution:
Staphylococcus aureus 1,119,000 0.00 0.00 0.00 0.00
Escherichia coli 1,060,000 0.00 0.00 0.00 0.00
Spores of bacillus subtilin 1,067,000 0.00 0.00 0.00 0.00
Candida albicans 128,000 12.60 28.56 37.76 43.82
Annotate: compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (1) contains 0.5% povidone iodine and 1% terbinafine HCl, and iodophor solution contains 0.5% povidone iodine, and terbinafine HCl solution contains 1% terbinafine HCl.
Table 7 compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (2) and component medicine thereof are to the killing effect of several microorganisms
The strain classification contrasts different (Min) killing rates action time (%) of average bacterium number
(cfu/ sheet) 135 10
Compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (2):
Staphylococcus aureus 1,119,000 99.28 99.99 100.00 100.00
Escherichia coli 1,060,000 95.33 99.99 100.00 100.00
Spores of bacillus subtilin 1,067,000 72.16 95.21 99.99 100.00
Candida albicans 128,000 97.64 99.99 100.00 100.00
Iodophor solution:
Staphylococcus aureus 1,119,000 99.56 99.85 99.99 100.00
Escherichia coli 1,060,000 92.81 99.97 99.99 100.00
Spores of bacillus subtilin 1,067,000 65.52 93.67 99.68 100.00
Candida albicans 128,000 76.57 99.62 99.92 100.00
Naftifine hydrochloride solution:
Staphylococcus aureus 1,119,000 0.00 0.00 0.00 0.00
Escherichia coli 1,060,000 0.00 0.00 0.00 0.00
Spores of bacillus subtilin 1,067,000 0.00 0.00 0.00 0.00
Candida albicans 128,000 0.00 0.00 0.00 0.00
Annotate: compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (2) contains 0.5% povidone iodine and 1% naftifine hydrochloride, and iodophor solution contains 0.5% povidone iodine, and naftifine hydrochloride solution contains 1% naftifine hydrochloride.
Table 8 compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (3) and component medicine thereof are to the killing effect of several microorganisms
The strain classification contrasts different (Min) killing rates action time (%) of average bacterium number
(cfu/ sheet) 135 10
Compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (3):
Staphylococcus aureus 1,119,000 96.20 99.99 100.00 100.00
Escherichia coli 1,060,000 95.29 99.99 100.00 100.00
Spores of bacillus subtilin 1,067,000 64.87 94.86 99.99 100.00
Candida albicans 128,000 98.10 99.99 100.00 100.00
Iodophor solution:
Staphylococcus aureus 1,119,000 99.56 99.85 99.99 100.00
Escherichia coli 1,060,000 92.81 99.97 99.99 100.00
Spores of bacillus subtilin 1,067,000 65.52 93.67 99.68 100.00
Candida albicans 128,000 76.57 99.62 99.92 100.00
Butenafine Hydrochloride solution:
Staphylococcus aureus 1,119,000 0.00 0.00 0.00 0.00
Escherichia coli 1,060,000 0.00 0.00 0.00 0.00
Spores of bacillus subtilin 1,067,000 0.00 0.00 0.00 0.00
Candida albicans 128,000 2.21 18.32 28.36 33.48
Annotate: compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (3) contains 0.5% povidone iodine and 1% Butenafine Hydrochloride, and iodophor solution contains 0.5% povidone iodine, and Butenafine Hydrochloride solution contains 1% Butenafine Hydrochloride.
Table 9 compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (4) and component medicine thereof are to the killing effect of several microorganisms
The strain classification contrasts different (Min) killing rates action time (%) of average bacterium number
(cfu/ sheet) 135 10
Compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (4):
Staphylococcus aureus 1,119,000 99.76 99.99 100.00 100.00
Escherichia coli 1,060,000 96.68 99.99 100.00 100.00
Spores of bacillus subtilin 1,067,000 71.88 96.24 99.99 100.00
Candida albicans 128,000 98.12 99.99 100.00 100.00
Iodophor solution:
Staphylococcus aureus 1,119,000 99.56 99.85 99.99 100.00
Escherichia coli 1,060,000 92.81 99.97 99.99 100.00
Spores of bacillus subtilin 1,067,000 65.52 93.67 99.68 100.00
Candida albicans 128,000 76.57 99.62 99.92 100.00
Fluconazol solution:
Staphylococcus aureus 1,119,000 0.00 0.00 0.00 0.00
Escherichia coli 1,060,000 0.00 0.00 0.00 0.00
Spores of bacillus subtilin 1,067,000 0.00 0.00 0.00 0.00
Candida albicans 128,000 0.00 0.00 0.00 0.00
Annotate: compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (4) contains 0.5% povidone iodine and 1% fluconazol, and iodophor solution contains 0.5% povidone iodine, and fluconazol solution contains 1% fluconazol.
Table 10 compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (5) and component medicine thereof are to the killing effect of several microorganisms
The strain classification contrasts different (Min) killing rates action time (%) of average bacterium number
(cfu/ sheet) 135 10
Compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (5):
Staphylococcus aureus 1,119,000 99.90 99.99 100.00 100.00
Escherichia coli 1,060,000 96.85 99.99 100.00 100.00
Spores of bacillus subtilin 1,067,000 68.42 96.63 99.99 100.00
Candida albicans 128,000 96.29 99.99 100.00 100.00
Iodophor solution:
Staphylococcus aureus 1,119,000 99.56 99.85 99.99 100.00
Escherichia coli 1,060,000 92.81 99.97 99.99 100.00
Spores of bacillus subtilin 1,067,000 65.52 93.67 99.68 100.00
Candida albicans 128,000 76.57 99.62 99.92 100.00
Ciclopirox olamine solution:
Staphylococcus aureus 1,119,000 0.00 0.00 0.00 0.00
Escherichia coli 1,060,000 0.00 0.00 0.00 0.00
Spores of bacillus subtilin 1,067,000 0.00 0.00 0.00 0.00
Candida albicans 128,000 5.25 12.86 21.06 39.82
Annotate: compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen solution (5) contains 0.5% povidone iodine and 1% ciclopirox olamine, and iodophor solution contains 0.5% povidone iodine, and ciclopirox olamine solution contains 1% ciclopirox olamine.
Three, the clinical case report for example
The present composition, be povidone iodine: (povidone iodine weight refers to amount of iodine for terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine formulation weight part, down with) when the proportioning ratio is 0.02～2.0: 0.01～5.0 formulated topical agent and disinfectant, the disease of treatment trauma infection contamination, pre-bacteriological protection, fungal infection and fungus, bacteria mixed infection is had better therapeutic effect and disinfective action.
Example 1. Liu * *, the male, 42 years old, because of itching, a left side inboard skin lesion companion of foot 2-4 toe went to a doctor in 1 week, be diagnosed as tinea pedis and toenail tinea (first 3, first 4).Sings and symptoms is obvious before the treatment, and fungal culture is a Candida albicans.Then give the treatment of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen tincture, logotype 16 week use, the 2nd all sings and symptomses disappear, and tinea pedis clinical recovery, tinea unguium are in 16 weeks, and fungus microscope examination all shows feminine gender with cultivating, clinical recovery, toenail recovers normally.
Example 2. Cai * *, the man, 32 years old, because of the breakage of left hand skin of back, begin not draw attention, back bacterial infection, the red and swollen suppuration is diagnosed as the wound bacterial infection, and antibacterial culturing is an infection of staphylococcus aureus.Then give the external of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen spray, 1 week of logotype, recovery from illness.
Example 3. Hus * *, the male, 24 years old, because of itching, bifilar inboard skin lesion companion go to a doctor April, be diagnosed as tinea cruris.Sings and symptoms is obvious before the treatment, and fungal culture is a trichophyton.Then give 1 week of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen liniment logotype, the 2nd all sings and symptomses disappear, and fungus microscope examination and cultivation all show negative, clinical recovery.
Example 4. Liu * *, the women, 35 years old, because of careless upper limb right forearm breakage, bled in many places, disinfect with the compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen disinfectant lotion, every day secondary, for three days on end, wound is not seen infection, wound healing after 4 days.
Case 5. Huangs * *, the male, 28 years old, because of itching, right cervical region skin lesion companion went to a doctor in 2 weeks, and the fungus microscope examination positive is diagnosed as the waist tinea corporis, and sings and symptoms is obvious before the treatment, and fungal culture is a trichophyton.Then give the external of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen varnish, 1 week of logotype, the clinical and mycology recovery from illness of the 2nd week.
Case 6. Yin * *, the women, 22 years old, because of itching, preceding chest and back skin lesion companion went to a doctor in 1 year, be diagnosed as tinea versicolor.Sings and symptoms is obviously long-pending before the treatment, the fungus microscope examination positive.Then give the compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen lotion for treatment, in 1 week of logotype, sings and symptoms disappears during the 2nd all drug withdrawal, negative fungal examination, clinical recovery.
Case 7. season * *, the male, 35 years old, the companion itched 2 years because of the both legs skin lesion, itched recently and scratched, and the state of an illness increases the weight of, and mixes red and swollen the prescription on individual diagnosis, is diagnosed as antibacterial and fungus concurrent infection.Sings and symptoms is all heavier before the treatment, and microscopy is cultivated and is alpha fungus, and antibacterial culturing is positive, gives the treatment of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen gel then, and in 2 weeks of logotype, sings and symptoms disappears substantially during drug withdrawal, and fungus microscope examination and antibacterial culturing are negative; The 3rd all clinical recoveries.
Case 8. Xiao * *, the women, 26 years old, because of itching, external genital portion skin lesion companion goes to a doctor March, be diagnosed as condyloma acuminatum, give the treatment of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen liniment then, in 5 weeks of logotype, sings and symptoms disappears during drug withdrawal, clinically is judged to healing.
Case 9. holes * *, the male, 32 years old, because of itching, the right side inboard skin lesion companion of foot 3-5 toe went to a doctor in 1 week, be diagnosed as tinea pedis.Sings and symptoms is obvious before the treatment, and fungal culture is a Candida albicans.Then give 1 week of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen ointment logotype, the 2nd all sings and symptomses disappear, and fungus microscope examination and cultivation all show negative, clinical recovery.
10. maos of cases * *, the women, 25 years old, because of skin lesion companion between the biped toe itches half a year, to itch recently and scratch, the state of an illness increases the weight of, and mixes red and swollen the prescription on individual diagnosis, is diagnosed as between toe the type tinea pedis and mixes bacterial infection.Sings and symptoms is all heavier before the treatment, and microscopy is cultivated and is alpha fungus, and antibacterial culturing is golden yellow staphylococcus.Then give 1 week of compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen emulsifiable paste logotype, sings and symptoms disappears substantially during drug withdrawal, and fungus microscope examination and antibacterial culturing are all negative; The 2nd week, clinical and fungus, bacteriology checking were all fully recovered.
Case 11. ten thousand * *, the male, 20 years old, excuse portion suffered from furuncle and phyma and mixes prescription on individual diagnosis in red and swollen 5 days, and antibacterial culturing is golden yellow staphylococcus, is diagnosed as suppurative folliculitis.Sings and symptoms is obvious before the treatment, gives compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen antiseptic solution sterilizing then, and logotype is used 5 times, and sings and symptoms disappeared in the 5th day, antibacterial culturing feminine gender, clinical recovery.
The specific embodiment
Embodiment 1
Povidone iodine compositions tincture of the present invention
Take by weighing povidone iodine (PVP-I) 0.05 gram (referring to available iodine content, down together), ciclopirox olamine 5.0 gram raw materials by 0.05: 5.0 formula proportion, add 50ml ethanol, 20ml propylene glycol, the formulated tincture 100ml of 10ml glycerol and surplus distilled water.
Embodiment 2
Povidone iodine compositions ointment of the present invention
Take by weighing povidone iodine (PEG-I) 2.0 grams, fluconazol 0.1 gram raw material by 2.0: 0.1 formula proportion, dissolve with small amount of ethanol earlier, use the 0/W dosage form, excipient is octadecanol 4 grams, stearic acid 10 grams, glyceryl monostearate 5 grams, vaseline 6 grams, glycerol 10 grams, and triethanolamine 0.8 gram and surplus distilled water are mixed with ointment 100 grams.
Embodiment 3
Povidone iodine compositions ointment of the present invention
Take by weighing povidone iodine (PVP-I) 0.5 gram, Butenafine Hydrochloride 0.5 gram raw material by 0.3: 0.5 formula proportion, dissolve with small amount of ethanol earlier, use the 0/W dosage form, excipient is octadecanol 4 grams, stearic acid 4 grams, glyceryl monostearate 3.5 grams, vaseline 10 grams, glycerol 10 grams, and soil temperature-80 2 gram and surplus distilled water are mixed with ointment 100 grams.
Embodiment 4
Povidone iodine composition solution of the present invention agent or lotion
Take by weighing povidone iodine (PVP-I) 0.3 gram, terbinafine HCl 0.3 gram raw material by 0.3: 0.3 formula proportion, add 20ml ethanol, 20ml propylene glycol, formulated solution of surplus distilled water or lotion 100ml.
Embodiment 5
Povidone iodine composition suppository of the present invention
Take by weighing povidone iodine (PEG-I) 0.3 gram, terbinafine HCl 0.1 gram raw material, Polyethylene Glycol-1,000 73.5 grams, Polyethylene Glycol-4,000 25 grams by 0.3: 0.1 formula proportion.Poly-7 glycol-1000 and Polyethylene Glycol-4000 fusing during preparation are treated to add when temperature is reduced to 50 ℃ medicine (earlier medicine being ground into fine powder) and are stirred evenly, and formulated routinely suppository 100ml irritates mould etc. then.
Embodiment 6
Povidone iodine compositions spray of the present invention
Take by weighing povidone iodine (PEG-I) 0.25 gram, naftifine hydrochloride 0.3 gram raw material by 0.25: 0.3 formula proportion, add 20ml ethanol, the formulated spray 100ml of 20ml glycerol and surplus distilled water.
Embodiment 7
Povidone iodine compositions ointment of the present invention
Take by weighing povidone iodine (PVP-I) 2.0 grams, Butenafine Hydrochloride 0.1 gram raw material by 0.5: 1.0 formula proportion, dissolve with small amount of ethanol earlier, dissolve with small amount of ethanol earlier, use the 0/W dosage form, excipient is octadecanol 4 grams, stearic acid 4 grams, glyceryl monostearate 3.5 grams, vaseline 10 grams, glycerol 10 grams, and soil temperature-80 2 gram and surplus distilled water are mixed with ointment 100 grams.
Embodiment 8
Povidone iodine compositions membrane of the present invention
Take by weighing povidone iodine (PVP-I) 0.5 gram, terbinafine HCl 0.5 gram raw material by 0.5: 0.5 formula proportion, use dissolve with ethanol earlier, add in the good polyvinyl alcohol liquid of a certain amount of dissolving, with adding with stirring, add 30% glycerol, adding distil water is to 100g, stirs evenly to get final product.
Embodiment 9
Povidone iodine compositions ointment of the present invention
Take by weighing povidone iodine (PEG-I) 1.0 grams, Butenafine Hydrochloride 0.5 gram raw material by 1.0: 0.5 formula proportion, dissolve with small amount of ethanol earlier, use the 0/W dosage form, excipient is octadecanol 4 grams, stearic acid 10 grams, glyceryl monostearate 5 grams, vaseline 6 grams, glycerol 10 grams, and triethanolamine 0.8 gram and surplus distilled water are mixed with ointment 100 grams.
Embodiment 10
Povidone iodine compositions liquid disinfectant of the present invention
Take by weighing povidone iodine (PVP-I) 0.5 gram, ciclopirox olamine 0.3 gram raw material by 0.5: 0.3 formula proportion, add 25ml ethanol, 10ml glycerol and the formulated disinfectant 100ml of surplus distilled water.
Embodiment 11
Povidone iodine compositions disinfectant powder of the present invention
Take by weighing povidone iodine (PEG-I) 0.2 gram, terbinafine HCl 0.1 gram raw material by 0.2: 0.1 formula proportion, with the small amount of ethanol dissolving, add starch 20g, the formulated powder 100g of Pulvis Talci surplus earlier.
Embodiment 12
Povidone iodine compositions sterilization granule of the present invention or effervescent tablet
Take by weighing povidone iodine (PVP-I) 0.5 gram, ciclopirox olamine 0.6 gram raw material by 0.5: 0.6 formula proportion, add a certain amount of citric acid, sodium bicarbonate, starch and Pulvis Talci, mixing, granulate is made granule, or tabletting, makes effervescent tablet.
Claims (9)
1, a kind of bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine comprises following component: povidone iodine and terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine.
2, bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine according to claim 1, described medicine can be the medicament that following weight portion proportioning ratio component is made, i.e. povidone iodine: terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine are 0.05～2.0: 0.1～5.0.
3, bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine according to claim 1, described medicine can be the medicament that the component of following weight portion proportioning ratio is made, i.e. povidone iodine: terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine are 0.2～1.0: 0.5～2.0.
4, bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine according to claim 1, the medicament that the component that described bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine can be following weight portion proportioning ratio is made, i.e. povidone iodine: terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine are 0.5: 1.0.
5, bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine according to claim 1, described povidone iodine can be selected from one of indefinite form conjugate of following iodine and surfactant: polyvinylpyrrolidone-iodine, Nonyl pheno dodecane alcohol ether-iodine, NPE-iodine, PEG-I, alkylsulfonate-iodine, poly-third oxygen ether-iodine, alkane alkene imidazoles-iodine, polyvinyl alcohol-iodine, ring glucoside-iodine.
6, bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine according to claim 1, described povidone iodine is polyvinylpyrrolidone-iodine.
7, bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine according to claim 1 also comprises available adjuvant on the pharmaceutics.
8, bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine according to claim 1, described medicament can be solution, lotion, tincture, spray, liniment, ointment, emulsifiable paste, membrane, varnish, suppository, gel skin and mucosa exterior-applied formulation; Or solution, sterilized cotton ball, disinfecting cotton swab, granule, disinfectant tablet, ointment, gel, membrane, effervescent and disinfectant powder sterilization dosage form.
9, a kind of preparation method of bactericidal compounded Dianfu-medicine prepared from iodine and hoevillite containing interhalogen medicine, may further comprise the steps: the ratio in one of claim 1-4 takes by weighing raw material povidone iodine, terbinafine HCl or naftifine hydrochloride or Butenafine Hydrochloride or fluconazol or ciclopirox olamine, and the preparation method preparation according to conventional external preparation for skin medicine or disinfectant promptly gets described sterilization, antibacterial medicines compositions again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03157132 CN1596908A (en) | 2003-09-16 | 2003-09-16 | Sterilization bacteria inhibition compound iodophor medicine and its preparation and preparation technology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03157132 CN1596908A (en) | 2003-09-16 | 2003-09-16 | Sterilization bacteria inhibition compound iodophor medicine and its preparation and preparation technology |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698358A (en) * | 2012-06-14 | 2012-10-03 | 杭州普瑞美克生物科技有限公司 | Preparation method for disposable compound iodine medical disinfecting large cotton bar |
| CN104548100A (en) * | 2015-01-13 | 2015-04-29 | 北京北大明德科技发展有限公司 | External composition for treating skin diseases |
| CN107115329A (en) * | 2017-04-28 | 2017-09-01 | 中国人民解放军第二军医大学第二附属医院 | A kind of compound Butenafine preparation and its application |
| CN107496448A (en) * | 2017-09-30 | 2017-12-22 | 蚌埠科卫消毒药剂有限公司 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
-
2003
- 2003-09-16 CN CN 03157132 patent/CN1596908A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698358A (en) * | 2012-06-14 | 2012-10-03 | 杭州普瑞美克生物科技有限公司 | Preparation method for disposable compound iodine medical disinfecting large cotton bar |
| CN104548100A (en) * | 2015-01-13 | 2015-04-29 | 北京北大明德科技发展有限公司 | External composition for treating skin diseases |
| CN104548100B (en) * | 2015-01-13 | 2017-09-12 | 北京北大明德科技发展有限公司 | A kind of dermopathic composition of external curing |
| CN107115329A (en) * | 2017-04-28 | 2017-09-01 | 中国人民解放军第二军医大学第二附属医院 | A kind of compound Butenafine preparation and its application |
| CN107496448A (en) * | 2017-09-30 | 2017-12-22 | 蚌埠科卫消毒药剂有限公司 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
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